MCID: AND014
MIFTS: 39

Androgenic Alopecia malady

Rare diseases, Skin diseases categories
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Summaries for Androgenic Alopecia

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21Genetics Home Reference, 43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Androgenetic alopecia is a common form of hair loss in both men and women. in men, hair is usually lost in a well-defined pattern, beginning above both temples and is usually referred to as male-pattern baldness. over time, the hairline recedes to form a characteristic 'm' shape. hair also thins near the top of the head, often progressing to partial or complete baldness. the pattern of hair loss in women differs from men (female pattern hair loss). in women, the hair becomes thinner all over the head, and the hairline does not recede. androgenetic alopecia in women rarely leads to total baldness. a variety of genetic and environmental factors likely play a role in causing this condition. mutations in the ar gene have also been associated with androgenetic alopecia. last updated: 8/19/2011

MalaCards: Androgenic Alopecia, also known as androgenetic alopecia, is related to alopecia and prostate cancer. An important gene associated with Androgenic Alopecia is HR (hair growth associated), and among its related pathways is Transcription Androgen Receptor nuclear signaling. The compounds testosterone undecanoate and epitestosterone have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and prostate.

Genetics Home Reference:21 Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness.

Wikipedia:65 Androgenic alopecia (also known as androgenetic alopecia, alopecia androgenetica, male pattern baldness)... more...

Description from OMIM:47 109200,612421,300710

Aliases & Classifications for Androgenic Alopecia

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8Disease Ontology, 43NIH Rare Diseases, 21Genetics Home Reference, 62UMLS, 45Novoseek, 47OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

androgenic alopecia 8 43 21
androgenetic alopecia 8 43 21 62
alopecia androgenetica, male pattern baldness 8
female pattern alopecia 62
female pattern baldness 21
male pattern alopecia 21
male pattern baldness 21
alopecia androgenetic 45
pattern baldness 21


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Disease Ontology8 DOID:0050801
ICD1025 L64

Related Diseases for Androgenic Alopecia

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17GeneCards, 18GeneDecks
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Diseases related to Androgenic Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia31.1SHBG, HR
2prostate cancer30.7KLK3, SHBG, SRD5A1
3prostatitis30.1KLK3, SRD5A1
4hyperandrogenism30.1PRL, SHBG, SRD5A1
5polycystic ovary syndrome30.1SHBG, SRD5A1, PRL
6breast cancer30.0SHBG, PRL, SRD5A1, KLK3
7blindness10.6
8acne10.5
9coronary artery disease10.3
10artery disease10.3
11dermatitis10.3
12hypertension10.3
13psoriasis10.3
14frontal fibrosing alopecia10.3
15alopecia, androgenetic, 110.3
16alopecia, androgenetic, 310.3
17alopecia, androgenetic, 210.3
18hypertrichosis10.2
19lupus erythematosus10.2
20discoid lupus erythematosus10.2
21ichthyosis vulgaris10.2
22alexithymia10.2
23adrenoleukodystrophy10.2
24atopic dermatitis10.2
25atherosclerosis10.2
26contact dermatitis10.2
27diabetes mellitus10.2
28hermaphroditism10.2
29hyperglycemia10.2
30personality disorder10.2
31thyroiditis10.2
32central centrifugal cicatricial alopecia10.2
33hypotrichosis simplex10.2
34hypotrichosis 110.2
35endotheliitis10.2
36telogen effluvium10.1
37alopecia areata10.1
38late-onset congenital adrenal hyperplasia10.1
39atopy10.1
40insulin resistance10.1
41hypogonadism, hypergonadotropic10.0PRL, SHBG
42varicocele10.0PRL, SHBG
43ovarian disease10.0SHBG, PRL
44amenorrhea10.0SHBG, PRL
45premature ovarian failure10.0SHBG, PRL
46precocious puberty10.0SHBG, PRL
47partial androgen insensitivity syndrome10.0SHBG, SRD5A1
48hypopituitarism10.0SHBG, PRL
49androgen insensitivity syndrome10.0SRD5A1, SHBG
50acromegaly10.0PRL, SHBG

Graphical network of the top 20 diseases related to Androgenic Alopecia:



Diseases related to androgenic alopecia

Symptoms for Androgenic Alopecia

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47OMIM
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Clinical features from OMIM:

109200,612421,300710

Drugs & Therapeutics for Androgenic Alopecia

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Androgenic Alopecia

Search NIH Clinical Center for Androgenic Alopecia

Genetic Tests for Androgenic Alopecia

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Anatomical Context for Androgenic Alopecia

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33MalaCards
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MalaCards organs/tissues related to Androgenic Alopecia:

33
Skin, Ovary, Prostate

Animal Models for Androgenic Alopecia or affiliated genes

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Publications for Androgenic Alopecia

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52PubMed
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Articles related to Androgenic Alopecia:

(show all 18)
idTitleAuthorsYear
1
An epidemiological study of androgenic alopecia in 3114 Korean patients. (24341477)
2014
2
Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities. (24386074)
2013
3
Use of body and beard donor hair in surgical treatment of androgenic alopecia. (23960316)
2013
4
Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study. (23807837)
2013
5
Promising therapies for treating and/or preventing androgenic alopecia. (22735503)
2012
6
Clinical severity does not reliably predict quality of life in women with alopecia areata, telogen effluvium, or androgenic alopecia. (21601948)
2012
7
Finasteride in the treatment of female pattern (androgenic) alopecia: a case report and review of the literature. (22988650)
2012
8
Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA. (22363845)
2011
9
Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial. (17196507)
2007
10
Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome? (16552990)
2005
11
Expression of androgen receptor coactivator ARA70/ELE1 in androgenic alopecia. (16115056)
2005
12
Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis. (15488702)
2004
13
Variant 1859G-->A (Arg620Gln) of the 'hairless' gene: absence of association with papular atrichia or androgenic alopecia. (11410842)
2001
14
Hormonal profile in men with premature androgenic alopecia]. (10953626)
2000
15
Urinary steroids in women with androgenic alopecia. (10751586)
2000
16
A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia. (7923828)
1994
17
Plasma C19 steroid sulphate levels and indices of androgen bioavailability in female pattern androgenic alopecia. (2139595)
1990
18
Plasma testosterone glucosiduronate: a reliable indicator of female hyperandrogenism (idiopathic hirsutism and androgenic alopecia). (7226567)
1980

Variations for Androgenic Alopecia

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Expression for genes affiliated with Androgenic Alopecia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Androgenic Alopecia

Search GEO for disease gene expression data for Androgenic Alopecia.

Pathways for genes affiliated with Androgenic Alopecia

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50PathCards, 60Thomson Reuters
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Pathways related to Androgenic Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.4KLK3, SRD5A1

Compounds for genes affiliated with Androgenic Alopecia

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45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 51PharmGKB, 3BitterDB
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Compounds related to Androgenic Alopecia according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1testosterone undecanoate459.9KLK3, SHBG
2epitestosterone459.9SRD5A1, SHBG
3norgestrel459.9KLK3, SHBG
4chlormadinone acetate459.9SHBG, KLK3
5formestane459.9SHBG, SRD5A1
6enterolactone459.8SHBG, SRD5A1
7r1881459.8KLK3, SHBG
8permixon459.8KLK3, SRD5A1
9atrazine459.8SHBG, KLK3
10norgestimate45 1110.8SRD5A1, SHBG
11alfuzosin45 1110.8SRD5A1, KLK3
12dutasteride45 1110.7KLK3, SRD5A1
13terazosin45 1110.7SRD5A1, KLK3
14tamsulosin45 29 1111.7SRD5A1, KLK3
15desogestrel45 1110.7SHBG, SRD5A1
16allopregnanolone459.6SHBG, SRD5A1
1711 deoxycortisol459.5PRL, SHBG
18megestrol acetate459.5KLK3, SHBG
19ment459.4KLK3, SRD5A1, SHBG
20androstenediol459.4SRD5A1, SHBG, KLK3
21goserelin45 29 1111.4SRD5A1, KLK3, SHBG
22hydroxyflutamide45 2910.4SHBG, KLK3, SRD5A1
23finasteride45 61 24 1112.4SHBG, SRD5A1, KLK3
245alpha-androstane-3alpha,17beta-diol459.4SHBG, SRD5A1
253-alpha-androstanediol glucuronide45 2410.4SRD5A1, KLK3, SHBG
26spironolactone45 61 29 51 1113.4KLK3, SRD5A1, SHBG
27ketoconazole45 29 24 1112.4KLK3, SRD5A1, SHBG
28progestins459.4SRD5A1, SHBG, KLK3
29buserelin45 29 1111.3KLK3, PRL
30leuprolide acetate459.3KLK3, SHBG, PRL
31levonorgestrel45 61 29 1112.3SHBG, SRD5A1, PRL
3217-hydroxyprogesterone45 2410.3SHBG, SRD5A1, PRL
33androstenedione45 2410.3SRD5A1, SHBG, PRL
34leuprolide45 61 29 1112.2SRD5A1, PRL, KLK3
35progestin459.2SHBG, PRL, SRD5A1
36estrone45 29 24 1112.2SRD5A1, PRL, SHBG
37hydrocortisone45 3 61 1112.2SHBG, KLK3, PRL
38thyroxine45 2410.1PRL, SHBG, KLK3
39calcitriol45 61 24 1112.1KLK3, SHBG, SRD5A1
40lanreotide45 2910.0PRL, KLK3
41cyproteroneacetate458.8SRD5A1, KLK3, SHBG, PRL
42flutamide45 61 1110.8SHBG, SRD5A1, KLK3, PRL
43dehydroepiandrosterone sulfate458.8PRL, SRD5A1, SHBG, KLK3
44dhea458.8SRD5A1, SHBG, KLK3, PRL
45dihydrotestosterone45 29 24 1111.8KLK3, SRD5A1, PRL, SHBG
46gnrh458.8KLK3, PRL, SHBG, SRD5A1
47estradiol45 24 1110.7PRL, KLK3, SHBG, SRD5A1
48testosterone45 61 24 1111.6KLK3, SHBG, PRL, SRD5A1
49steroid458.6SHBG, KLK3, PRL, SRD5A1
50dexamethasone45 51 29 1111.6PRL, KLK3, SRD5A1, SHBG

GO Terms for genes affiliated with Androgenic Alopecia

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Products for genes affiliated with Androgenic Alopecia

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Sources for Androgenic Alopecia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet