MCID: AND014
MIFTS: 34

Androgenic Alopecia malady

Skin category

Summaries for Androgenic Alopecia

Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Androgenetic alopecia is a common form of hair loss in both men and women. in men, hair is usually lost in a well-defined pattern, beginning above both temples and is usually referred to as male-pattern baldness. over time, the hairline recedes to form a characteristic 'm' shape. hair also thins near the top of the head, often progressing to partial or complete baldness. the pattern of hair loss in women differs from men (female pattern hair loss). in women, the hair becomes thinner all over the head, and the hairline does not recede. androgenetic alopecia in women rarely leads to total baldness. a variety of genetic and environmental factors likely play a role in causing this condition. mutations in the ar gene have also been associated with androgenetic alopecia. last updated: 8/19/2011

MalaCards: Androgenic Alopecia, also known as androgenetic alopecia, is related to alopecia and acne. An important gene associated with Androgenic Alopecia is SHBG (sex hormone-binding globulin), and among its related pathways is Transcription Androgen Receptor nuclear signaling. The compounds tamsulosin and testosterone undecanoate have been mentioned in the context of this disorder. Affiliated tissues include ovary and prostate.

Genetics Home Reference:21 Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness.

Wikipedia:64 Androgenic alopecia (also known as androgenetic alopecia, alopecia androgenetica, male pattern baldness)... more...

Description from OMIM:47 612421,109200,300710

Aliases & Classifications for Androgenic Alopecia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 21Genetics Home Reference, 45Novoseek, 61UMLS, 47OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

androgenic alopecia 8 43 21
androgenetic alopecia 8 43 21 61
alopecia androgenetica, male pattern baldness 8
female pattern alopecia 61
female pattern baldness 21
male pattern alopecia 21
male pattern baldness 21
alopecia androgenetic 45
pattern baldness 21


External Ids:

Disease Ontology8 DOID:0050801
ICD1025 L64

Related Diseases for Androgenic Alopecia

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17GeneCards, 18GeneDecks
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Diseases related to Androgenic Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia31.0HR, SHBG
2acne30.7SHBG
3hyperandrogenism30.0SRD5A1, SHBG, PRL
4polycystic ovary syndrome30.0PRL, SHBG, SRD5A1
5alopecia, androgenetic, 310.4
6coronary artery disease,10.3
7diffuse alopecia areata10.3
8frontal fibrosing alopecia10.3
9hypotrichosis simplex10.3
10alopecia, androgenetic, 110.3
11coronary heart disease10.3
12alopecia, androgenetic, 210.3
13discoid lupus erythematosus10.2
14ichthyosis vulgaris10.1
15atopic dermatitis10.1
16adrenoleukodystrophy10.1
17alexithymia10.1
18atherosclerosis10.1
19central centrifugal cicatricial alopecia10.1
20telogen effluvium10.1
21alopecia areata10.1
22late-onset congenital adrenal hyperplasia10.1
23atopy10.1
24insulin resistance10.1
25prolactinoma10.0PRL
26growth hormone deficiency10.0PRL
27panhypopituitarism10.0PRL
28acanthosis nigricans10.0SHBG
29alzheimer's disease10.0SHBG
30leydig cell tumor10.0SRD5A1
31pituitary adenoma10.0PRL
32hypospadias10.0SRD5A1
33hypogonadotropism10.0PRL
34prostatic hypertrophy10.0KLK3
35partial androgen insensitivity syndrome10.0SHBG, SRD5A1
36oligospermia10.0SRD5A1, PRL
37wermer syndrome10.0SRD5A1, PRL
38hypogonadism, hypergonadotropic10.0PRL, SHBG
39androgen insensitivity syndrome10.0SRD5A1, SHBG
40acromegaly10.0SHBG, PRL
41ovarian disease10.0PRL, SHBG
42premature ovarian failure10.0PRL, SHBG
43obesity10.0SRD5A1, SHBG
44precocious puberty10.0PRL, SHBG
45hypothyroidism10.0PRL, SHBG
46varicocele10.0SHBG, PRL
47prostatic adenoma10.0KLK3, SRD5A1
48prostate cancer10.0KLK3, SRD5A1
49urinary tract obstruction10.0KLK3, SRD5A1
50hypopituitarism10.0PRL, SHBG

Graphical network of the top 20 diseases related to Androgenic Alopecia:



Diseases related to androgenic alopecia

Clinical Features for Androgenic Alopecia

Sources:
47OMIM
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Clinical features from OMIM:

612421,109200,300710

Drugs & Therapeutics for Androgenic Alopecia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Androgenic Alopecia

Drug clinical trials:

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Search CenterWatch for Androgenic Alopecia

Genetic Tests for Androgenic Alopecia

Anatomical Context for Androgenic Alopecia

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33MalaCards
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MalaCards organs/tissues related to Androgenic Alopecia:

33
Ovary, Prostate

Animal Models for Androgenic Alopecia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Androgenic Alopecia

Sources:
51PubMed
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Articles related to Androgenic Alopecia:

(show all 19)
idTitleAuthorsYear
1
An epidemiological study of androgenic alopecia in 3114 Korean patients. (24341477)
2014
2
Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities. (24386074)
2013
3
Use of body and beard donor hair in surgical treatment of androgenic alopecia. (23960316)
2013
4
Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study. (23807837)
2013
5
Promising therapies for treating and/or preventing androgenic alopecia. (22735503)
2012
6
Clinical severity does not reliably predict quality of life in women with alopecia areata, telogen effluvium, or androgenic alopecia. (21601948)
2012
7
Finasteride in the treatment of female pattern (androgenic) alopecia: a case report and review of the literature. (22988650)
2012
8
Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA. (22363845)
2011
9
Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity. (16997533)
2007
10
Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial. (17196507)
2007
11
Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome? (16552990)
2005
12
Expression of androgen receptor coactivator ARA70/ELE1 in androgenic alopecia. (16115056)
2005
13
Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis. (15488702)
2004
14
Variant 1859G-->A (Arg620Gln) of the 'hairless' gene: absence of association with papular atrichia or androgenic alopecia. (11410842)
2001
15
Hormonal profile in men with premature androgenic alopecia]. (10953626)
2000
16
Urinary steroids in women with androgenic alopecia. (10751586)
2000
17
A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia. (7923828)
1994
18
Plasma C19 steroid sulphate levels and indices of androgen bioavailability in female pattern androgenic alopecia. (2139595)
1990
19
Plasma testosterone glucosiduronate: a reliable indicator of female hyperandrogenism (idiopathic hirsutism and androgenic alopecia). (7226567)
1980

Genetic Variations for Androgenic Alopecia

Expression for genes affiliated with Androgenic Alopecia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Androgenic Alopecia

Search GEO for disease gene expression data for Androgenic Alopecia.

Pathways for genes affiliated with Androgenic Alopecia

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12EMD Millipore
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Pathways related to Androgenic Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Androgen Receptor nuclear signaling
Hide members
9.1SRD5A1, KLK3

Compounds for genes affiliated with Androgenic Alopecia

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 24HMDB, 50PharmGKB
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Compounds related to Androgenic Alopecia according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1tamsulosin29 45 1112.2KLK3
2testosterone undecanoate459.9SHBG, KLK3
3norgestrel459.9KLK3, SHBG
4chlormadinone acetate459.9KLK3, SHBG
5r1881459.9KLK3, SHBG
6atrazine459.9KLK3, SHBG
711 deoxycortisol459.6SHBG, PRL
8epitestosterone459.6SRD5A1, SHBG
9formestane459.6SHBG, SRD5A1
10megestrol acetate459.6KLK3, SHBG
11enterolactone459.6SHBG, SRD5A1
12norgestimate45 1110.6SHBG, SRD5A1
13permixon459.5SRD5A1, KLK3
14alfuzosin45 1110.5KLK3, SRD5A1
15desogestrel45 1110.5SHBG, SRD5A1
16dutasteride45 1110.5KLK3, SRD5A1
17terazosin45 1110.4SRD5A1, KLK3
18allopregnanolone459.4SHBG, SRD5A1
19leuprolide acetate459.4SHBG, PRL, KLK3
20buserelin45 29 1111.3PRL, KLK3
215alpha-androstane-3alpha,17beta-diol459.2SHBG, SRD5A1
22hydrocortisone45 2 60 1112.2KLK3, PRL, SHBG
23thyroxine45 2410.2SHBG, PRL, KLK3
24ment459.2KLK3, SHBG, SRD5A1
25androstenediol459.2KLK3, SHBG, SRD5A1
26goserelin45 29 1111.2KLK3, SHBG, SRD5A1
27hydroxyflutamide45 2910.2SRD5A1, SHBG, KLK3
28finasteride45 60 11 2412.1KLK3, SHBG, SRD5A1
293-alpha-androstanediol glucuronide45 2410.1SRD5A1, SHBG, KLK3
30spironolactone50 45 60 29 1113.1SRD5A1, SHBG, KLK3
31ketoconazole45 29 11 2412.1SRD5A1, SHBG, KLK3
32progestins459.1KLK3, SHBG, SRD5A1
33levonorgestrel45 60 29 1112.0PRL, SHBG, SRD5A1
3417-hydroxyprogesterone45 2410.0SRD5A1, SHBG, PRL
35lanreotide45 2910.0PRL, KLK3
36androstenedione45 2410.0PRL, SHBG, SRD5A1
37progestin459.0SRD5A1, SHBG, PRL
38leuprolide45 60 29 1111.9SRD5A1, PRL, KLK3
39estrone45 29 11 2411.9PRL, SHBG, SRD5A1
40calcitriol45 60 11 2411.6SRD5A1, SHBG, KLK3
41cyproteroneacetate458.6SRD5A1, SHBG, PRL, KLK3
42flutamide45 60 1110.6SRD5A1, SHBG, PRL, KLK3
43dehydroepiandrosterone sulfate458.5SRD5A1, SHBG, PRL, KLK3
44dhea458.5SRD5A1, SHBG, PRL, KLK3
45dihydrotestosterone45 29 11 2411.5SRD5A1, SHBG, PRL, KLK3
46gnrh458.5KLK3, PRL, SHBG, SRD5A1
47estradiol45 11 2410.5KLK3, PRL, SHBG, SRD5A1
48testosterone45 60 11 2411.3SRD5A1, SHBG, PRL, KLK3
49steroid458.3SRD5A1, SHBG, PRL, KLK3
50dexamethasone45 50 29 1111.2SRD5A1, SHBG, PRL, KLK3

GO Terms for genes affiliated with Androgenic Alopecia

Products for genes affiliated with Androgenic Alopecia

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Sources for Androgenic Alopecia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet