MCID: AND014
MIFTS: 40

Androgenic Alopecia malady

Skin diseases category

Summaries for Androgenic Alopecia

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Androgenetic alopecia is a common form of hair loss in both men and women. in men, hair is usually lost in a well-defined pattern, beginning above both temples and is usually referred to as male-pattern baldness. over time, the hairline recedes to form a characteristic 'm' shape. hair also thins near the top of the head, often progressing to partial or complete baldness. the pattern of hair loss in women differs from men (female pattern hair loss). in women, the hair becomes thinner all over the head, and the hairline does not recede. androgenetic alopecia in women rarely leads to total baldness. a variety of genetic and environmental factors likely play a role in causing this condition. mutations in the ar gene have also been associated with androgenetic alopecia. last updated: 8/19/2011

MalaCards: Androgenic Alopecia, also known as androgenetic alopecia, is related to alopecia and prostate cancer. An important gene associated with Androgenic Alopecia is SHBG (sex hormone-binding globulin), and among its related pathways is Transcription Androgen Receptor nuclear signaling. The compounds tamsulosin and testosterone undecanoate have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and ovary.

Genetics Home Reference:21 Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness.

Wikipedia:63 Androgenic alopecia (also known as androgenetic alopecia, alopecia androgenetica, male pattern baldness)... more...

Description from OMIM:46 612421,109200,300710

Aliases & Classifications for Androgenic Alopecia

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 60UMLS, 44Novoseek, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

androgenic alopecia 8 42 21
androgenetic alopecia 8 42 21 60
alopecia androgenetica, male pattern baldness 8
female pattern alopecia 60
female pattern baldness 21
male pattern alopecia 21
male pattern baldness 21
alopecia androgenetic 44
pattern baldness 21


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Disease Ontology8 DOID:0050801
ICD1025 L64

Related Diseases for Androgenic Alopecia

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17GeneCards, 18GeneDecks
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Diseases related to Androgenic Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia30.9HR, SHBG
2prostate cancer30.8KLK3, SRD5A1
3acne30.7SHBG
4prostate disease30.1SRD5A1, KLK3
5hyperandrogenism30.0SRD5A1, SHBG, PRL
6polycystic ovary syndrome30.0PRL, SHBG, SRD5A1
7prostatitis30.0SRD5A1, KLK3
8x-linked ichthyosis10.4
9coronary artery disease10.3
10diffuse alopecia areata10.3
11dermatitis10.3
12hypertension10.3
13psoriasis10.3
14hypotrichosis simplex10.3
15alopecia, androgenetic, 110.3
16alopecia, androgenetic, 310.3
17alopecia, androgenetic, 210.3
18hypertrichosis10.2
19lupus erythematosus10.2
20ichthyosis vulgaris10.1
21atopic dermatitis10.1
22adrenoleukodystrophy10.1
23alexithymia10.1
24atherosclerosis10.1
25breast cancer10.1
26contact dermatitis10.1
27diabetes mellitus10.1
28hermaphroditism10.1
29hyperglycemia10.1
30personality disorder10.1
31thyroiditis10.1
32telogen effluvium10.0
33alopecia areata10.0
34late-onset congenital adrenal hyperplasia10.0
35prolactinoma10.0PRL
36growth hormone deficiency10.0PRL
37panhypopituitarism10.0PRL
38acanthosis nigricans10.0SHBG
39alzheimer's disease10.0SHBG
40leydig cell tumor10.0SRD5A1
41pituitary adenoma10.0PRL
42hypospadias10.0SRD5A1
43hypogonadotropism10.0PRL
44prostatic hypertrophy10.0KLK3
45partial androgen insensitivity syndrome10.0SHBG, SRD5A1
46oligospermia10.0SRD5A1, PRL
47wermer syndrome10.0SRD5A1, PRL
48hypogonadism, hypergonadotropic10.0PRL, SHBG
49androgen insensitivity syndrome10.0SRD5A1, SHBG
50acromegaly10.0SHBG, PRL

Graphical network of the top 20 diseases related to Androgenic Alopecia:



Diseases related to androgenic alopecia

Clinical Features for Androgenic Alopecia

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46OMIM
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Clinical features from OMIM:

612421,109200,300710

Drugs & Therapeutics for Androgenic Alopecia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Androgenic Alopecia

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Anatomical Context for Androgenic Alopecia

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32MalaCards
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MalaCards organs/tissues related to Androgenic Alopecia:

32
Skin, Prostate, Ovary, Pituitary

Animal Models for Androgenic Alopecia or affiliated genes

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Publications for Androgenic Alopecia

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50PubMed
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Articles related to Androgenic Alopecia:

(show all 49)
idTitleAuthorsYear
1
An epidemiological study of androgenic alopecia in 3114 Korean patients. (24341477)
2014
2
Increased androgen receptor messenger RNA in frontal-parietal hair follicles of women with androgenetic alopecia. (23479164)
2013
3
Preventive effects of Monascus on androgen-related diseases: androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer. (23651036)
2013
4
Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities. (24386074)
2013
5
Use of body and beard donor hair in surgical treatment of androgenic alopecia. (23960316)
2013
6
Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study. (23807837)
2013
7
Promising therapies for treating and/or preventing androgenic alopecia. (22735503)
2012
8
Clinical severity does not reliably predict quality of life in women with alopecia areata, telogen effluvium, or androgenic alopecia. (21601948)
2012
9
Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis. (21981665)
2012
10
Hair follicle stem cell differentiation is inhibited through cross-talk between Wnt/I^-catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia. (22283397)
2012
11
Finasteride in the treatment of female pattern (androgenic) alopecia: a case report and review of the literature. (22988650)
2012
12
Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with androgenetic alopecia mediated by epigenetics. (21410621)
2011
13
Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA. (22363845)
2011
14
Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla. (21167691)
2011
15
Hyposecretion of the Adrenal Androgen Dehydroepiandrosterone Sulfate (DHEA-S) in the Majority of the Alopecia Areata Patients: Is it a Primitive and Pathogenic Perturbation of Hypothalamic-Pituitary-Adrenal Axis? (21769240)
2011
16
Evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia. (21428981)
2011
17
Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene. (21073542)
2010
18
Androgen receptor copy number variation and androgenetic alopecia: a case-control study. (19340294)
2009
19
Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism. (19352298)
2009
20
Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia. (19538365)
2009
21
Effect of Cuscuta reflexa Roxb on androgen-induced alopecia. (18789055)
2008
22
The Ludwig pattern of androgenetic alopecia is due to a hierarchy of androgen sensitivity within follicular units that leads to selective miniaturization and a reduction in the number of terminal hairs per follicular unit. (18795932)
2008
23
Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia. (17256155)
2007
24
Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity. (16997533)
2007
25
Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial. (17196507)
2007
26
Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome? (16552990)
2005
27
Expression of androgen receptor coactivator ARA70/ELE1 in androgenic alopecia. (16115056)
2005
28
Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. (15902657)
2005
29
The E211 G>A androgen receptor polymorphism is associated with a decreased risk of metastatic prostate cancer and androgenetic alopecia. (15824176)
2005
30
Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis. (15488702)
2004
31
Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia. (12894997)
2003
32
Androgens and alopecia. (12573818)
2002
33
Contrast enhanced phototrichogram pinpoints scalp hair changes in androgen sensitive areas of male androgenetic alopecia. (12060475)
2002
34
Variant 1859G-->A (Arg620Gln) of the 'hairless' gene: absence of association with papular atrichia or androgenic alopecia. (11410842)
2001
35
Hormonal profile in men with premature androgenic alopecia]. (10953626)
2000
36
Role of androgens in female-pattern androgenetic alopecia, either alone or associated with other symptoms of hyperandrogenism. (11214820)
2000
37
Urinary steroids in women with androgenic alopecia. (10751586)
2000
38
Serum androgens and genetic linkage analysis in early onset androgenetic alopecia. (10469317)
1999
39
The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. (10495374)
1999
40
Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne. (9677254)
1998
41
Increased scalp skin and serum 5 alpha-reductase reduced androgens in a man relevant to the acquired progressive kinky hair disorder and developing androgenetic alopecia. (9301590)
1997
42
Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. (9284093)
1997
43
Androgen metabolism as it affects hair growth in androgenetic alopecia. (9238328)
1996
44
A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia. (7923828)
1994
45
Immunocytochemical localization of androgen receptors in the scalp of the stumptail macaque monkey, a model of androgenetic alopecia. (8151130)
1994
46
Hyperprolactinemia and hypophyseal hypothyroidism as cofactors in hirsutism and androgen-induced alopecia in women]. (1905280)
1991
47
Diagnostic approach to androgen disorders in women: acne, hirsutism, and alopecia. (2142637)
1990
48
Plasma C19 steroid sulphate levels and indices of androgen bioavailability in female pattern androgenic alopecia. (2139595)
1990
49
Plasma testosterone glucosiduronate: a reliable indicator of female hyperandrogenism (idiopathic hirsutism and androgenic alopecia). (7226567)
1980

Genetic Variations for Androgenic Alopecia

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Expression for genes affiliated with Androgenic Alopecia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Androgenic Alopecia

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Pathways for genes affiliated with Androgenic Alopecia

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12EMD Millipore
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Pathways related to Androgenic Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Transcription Androgen Receptor nuclear signaling
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9.1SRD5A1, KLK3

Compounds for genes affiliated with Androgenic Alopecia

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28IUPHAR, 44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Androgenic Alopecia according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1tamsulosin28 44 1112.2KLK3
2testosterone undecanoate449.9KLK3, SHBG
3chlormadinone acetate449.9SHBG, KLK3
4norgestrel449.9KLK3, SHBG
5r1881449.9SHBG, KLK3
6atrazine449.9KLK3, SHBG
711 deoxycortisol449.6PRL, SHBG
8epitestosterone449.6SHBG, SRD5A1
9formestane449.6SHBG, SRD5A1
10enterolactone449.6SHBG, SRD5A1
11megestrol acetate449.6SHBG, KLK3
12norgestimate44 1110.6SHBG, SRD5A1
13permixon449.5SRD5A1, KLK3
14alfuzosin44 1110.5SRD5A1, KLK3
15desogestrel44 1110.5SHBG, SRD5A1
16dutasteride44 1110.5SRD5A1, KLK3
17terazosin44 1110.4KLK3, SRD5A1
18allopregnanolone449.4SHBG, SRD5A1
19leuprolide acetate449.4KLK3, PRL, SHBG
20lanreotide44 2810.3KLK3, PRL
215alpha-androstane-3alpha,17beta-diol449.2SHBG, SRD5A1
22hydrocortisone44 2 59 1112.2KLK3, PRL, SHBG
23thyroxine44 2410.2KLK3, SHBG, PRL
24ment449.2SHBG, KLK3, SRD5A1
25androstenediol449.2SHBG, KLK3, SRD5A1
26goserelin44 28 1111.2SRD5A1, SHBG, KLK3
27hydroxyflutamide44 2810.2SRD5A1, KLK3, SHBG
28finasteride44 59 11 2412.1KLK3, SHBG, SRD5A1
293-alpha-androstanediol glucuronide44 2410.1SRD5A1, SHBG, KLK3
30spironolactone49 44 59 28 1113.1SRD5A1, SHBG, KLK3
31ketoconazole44 28 11 2412.1KLK3, SHBG, SRD5A1
32progestins449.1SRD5A1, SHBG, KLK3
33levonorgestrel44 59 28 1112.0SHBG, PRL, SRD5A1
3417-hydroxyprogesterone44 2410.0SRD5A1, PRL, SHBG
35buserelin44 28 1111.0KLK3, PRL
36androstenedione44 2410.0PRL, SHBG, SRD5A1
37progestin449.0PRL, SHBG, SRD5A1
38leuprolide44 59 28 1111.9KLK3, SRD5A1, PRL
39estrone44 28 11 2411.9SRD5A1, SHBG, PRL
40calcitriol44 59 11 2411.6SHBG, KLK3, SRD5A1
41cyproteroneacetate448.6SHBG, SRD5A1, PRL, KLK3
42flutamide44 59 1110.6KLK3, PRL, SHBG, SRD5A1
43dehydroepiandrosterone sulfate448.5PRL, SRD5A1, KLK3, SHBG
44dhea448.5KLK3, PRL, SRD5A1, SHBG
45dihydrotestosterone44 28 11 2411.5KLK3, PRL, SHBG, SRD5A1
46gnrh448.5KLK3, SRD5A1, SHBG, PRL
47estradiol44 11 2410.5KLK3, SRD5A1, PRL, SHBG
48testosterone44 59 11 2411.3SHBG, PRL, KLK3, SRD5A1
49steroid448.3SRD5A1, KLK3, SHBG, PRL
50dexamethasone44 49 28 1111.2SRD5A1, SHBG, PRL, KLK3

GO Terms for genes affiliated with Androgenic Alopecia

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Products for genes affiliated with Androgenic Alopecia

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Sources for Androgenic Alopecia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet