MCID: AND014
MIFTS: 39

Androgenic Alopecia malady

Rare diseases, Skin diseases categories

Summaries for Androgenic Alopecia

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22Genetics Home Reference, 44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Androgenetic alopecia is a common form of hair loss in both men and women. in men, hair is usually lost in a well-defined pattern, beginning above both temples and is usually referred to as male-pattern baldness. over time, the hairline recedes to form a characteristic 'm' shape. hair also thins near the top of the head, often progressing to partial or complete baldness. the pattern of hair loss in women differs from men (female pattern hair loss). in women, the hair becomes thinner all over the head, and the hairline does not recede. androgenetic alopecia in women rarely leads to total baldness. a variety of genetic and environmental factors likely play a role in causing this condition. mutations in the ar gene have also been associated with androgenetic alopecia. last updated: 8/19/2011

MalaCards: Androgenic Alopecia, also known as androgenetic alopecia, is related to alopecia and prostate cancer. An important gene associated with Androgenic Alopecia is HR (hair growth associated), and among its related pathways is Transcription Androgen Receptor nuclear signaling. The compounds testosterone undecanoate and epitestosterone have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and prostate.

Genetics Home Reference:22 Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness.

Wikipedia:66 Androgenic alopecia (also known as androgenetic alopecia, alopecia androgenetica, male pattern baldness)... more...

Description from OMIM:48 109200,612421,300710

Aliases & Classifications for Androgenic Alopecia

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9Disease Ontology, 44NIH Rare Diseases, 22Genetics Home Reference, 63UMLS, 46Novoseek, 48OMIM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

androgenic alopecia 9 44 22
androgenetic alopecia 9 44 22 63
alopecia androgenetica, male pattern baldness 9
female pattern alopecia 63
female pattern baldness 22
male pattern alopecia 22
male pattern baldness 22
alopecia androgenetic 46
pattern baldness 22


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Disease Ontology9 DOID:0050801
ICD1026 L64

Related Diseases for Androgenic Alopecia

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18GeneCards, 19GeneDecks
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Diseases related to Androgenic Alopecia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1alopecia31.1SHBG, HR
2prostate cancer30.7KLK3, SHBG, SRD5A1
3prostatitis30.1KLK3, SRD5A1
4hyperandrogenism30.1PRL, SHBG, SRD5A1
5polycystic ovary syndrome30.1SHBG, SRD5A1, PRL
6breast cancer30.0SHBG, PRL, SRD5A1, KLK3
7blindness10.6
8acne10.5
9coronary artery disease10.3
10artery disease10.3
11dermatitis10.3
12hypertension10.3
13psoriasis10.3
14frontal fibrosing alopecia10.3
15alopecia, androgenetic, 110.3
16alopecia, androgenetic, 310.3
17alopecia, androgenetic, 210.3
18hypertrichosis10.2
19lupus erythematosus10.2
20discoid lupus erythematosus10.2
21ichthyosis vulgaris10.2
22alexithymia10.2
23adrenoleukodystrophy10.2
24atopic dermatitis10.2
25atherosclerosis10.2
26contact dermatitis10.2
27diabetes mellitus10.2
28hermaphroditism10.2
29hyperglycemia10.2
30personality disorder10.2
31thyroiditis10.2
32central centrifugal cicatricial alopecia10.2
33hypotrichosis simplex10.2
34hypotrichosis 110.2
35endotheliitis10.2
36telogen effluvium10.1
37alopecia areata10.1
38late-onset congenital adrenal hyperplasia10.1
39atopy10.1
40insulin resistance10.1
41hypogonadism, hypergonadotropic10.0PRL, SHBG
42varicocele10.0PRL, SHBG
43ovarian disease10.0SHBG, PRL
44amenorrhea10.0SHBG, PRL
45premature ovarian failure10.0SHBG, PRL
46precocious puberty10.0SHBG, PRL
47partial androgen insensitivity syndrome10.0SHBG, SRD5A1
48hypopituitarism10.0SHBG, PRL
49androgen insensitivity syndrome10.0SRD5A1, SHBG
50acromegaly10.0PRL, SHBG

Graphical network of the top 20 diseases related to Androgenic Alopecia:



Diseases related to androgenic alopecia

Symptoms for Androgenic Alopecia

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48OMIM
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Clinical features from OMIM:

109200,612421,300710

Drugs & Therapeutics for Androgenic Alopecia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Androgenic Alopecia

Drug clinical trials:

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Search CenterWatch for Androgenic Alopecia

Genetic Tests for Androgenic Alopecia

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Anatomical Context for Androgenic Alopecia

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34MalaCards
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MalaCards organs/tissues related to Androgenic Alopecia:

34
Skin, Ovary, Prostate

Animal Models for Androgenic Alopecia or affiliated genes

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Publications for Androgenic Alopecia

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53PubMed
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Articles related to Androgenic Alopecia:

(show all 18)
idTitleAuthorsYear
1
An epidemiological study of androgenic alopecia in 3114 Korean patients. (24341477)
2014
2
Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities. (24386074)
2013
3
Use of body and beard donor hair in surgical treatment of androgenic alopecia. (23960316)
2013
4
Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study. (23807837)
2013
5
Promising therapies for treating and/or preventing androgenic alopecia. (22735503)
2012
6
Clinical severity does not reliably predict quality of life in women with alopecia areata, telogen effluvium, or androgenic alopecia. (21601948)
2012
7
Finasteride in the treatment of female pattern (androgenic) alopecia: a case report and review of the literature. (22988650)
2012
8
Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA. (22363845)
2011
9
Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomised controlled trial. (17196507)
2007
10
Premature androgenic alopecia and insulin resistance. Male equivalent of polycystic ovary syndrome? (16552990)
2005
11
Expression of androgen receptor coactivator ARA70/ELE1 in androgenic alopecia. (16115056)
2005
12
Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis. (15488702)
2004
13
Variant 1859G-->A (Arg620Gln) of the 'hairless' gene: absence of association with papular atrichia or androgenic alopecia. (11410842)
2001
14
Hormonal profile in men with premature androgenic alopecia]. (10953626)
2000
15
Urinary steroids in women with androgenic alopecia. (10751586)
2000
16
A prospective study of the prevalence of clear-cut endocrine disorders and polycystic ovaries in 350 patients presenting with hirsutism or androgenic alopecia. (7923828)
1994
17
Plasma C19 steroid sulphate levels and indices of androgen bioavailability in female pattern androgenic alopecia. (2139595)
1990
18
Plasma testosterone glucosiduronate: a reliable indicator of female hyperandrogenism (idiopathic hirsutism and androgenic alopecia). (7226567)
1980

Variations for Androgenic Alopecia

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Expression for genes affiliated with Androgenic Alopecia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Androgenic Alopecia

Search GEO for disease gene expression data for Androgenic Alopecia.

Pathways for genes affiliated with Androgenic Alopecia

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51PathCards, 61Thomson Reuters
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Pathways related to Androgenic Alopecia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.4KLK3, SRD5A1

Compounds for genes affiliated with Androgenic Alopecia

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46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Androgenic Alopecia according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1testosterone undecanoate469.9KLK3, SHBG
2epitestosterone469.9SRD5A1, SHBG
3norgestrel469.9KLK3, SHBG
4chlormadinone acetate469.9SHBG, KLK3
5formestane469.9SHBG, SRD5A1
6enterolactone469.8SHBG, SRD5A1
7r1881469.8KLK3, SHBG
8permixon469.8KLK3, SRD5A1
9atrazine469.8SHBG, KLK3
10norgestimate46 1210.8SRD5A1, SHBG
11alfuzosin46 1210.8SRD5A1, KLK3
12dutasteride46 1210.7KLK3, SRD5A1
13terazosin46 1210.7SRD5A1, KLK3
14tamsulosin46 30 1211.7SRD5A1, KLK3
15desogestrel46 1210.7SHBG, SRD5A1
16allopregnanolone469.6SHBG, SRD5A1
1711 deoxycortisol469.5PRL, SHBG
18megestrol acetate469.5KLK3, SHBG
19ment469.4KLK3, SRD5A1, SHBG
20androstenediol469.4SRD5A1, SHBG, KLK3
21goserelin46 30 1211.4SRD5A1, KLK3, SHBG
22hydroxyflutamide46 3010.4SHBG, KLK3, SRD5A1
23finasteride46 62 25 1212.4SHBG, SRD5A1, KLK3
245alpha-androstane-3alpha,17beta-diol469.4SHBG, SRD5A1
253-alpha-androstanediol glucuronide46 2510.4SRD5A1, KLK3, SHBG
26spironolactone46 62 30 52 1213.4KLK3, SRD5A1, SHBG
27ketoconazole46 30 25 1212.4KLK3, SRD5A1, SHBG
28progestins469.4SRD5A1, SHBG, KLK3
29buserelin46 30 1211.3KLK3, PRL
30leuprolide acetate469.3KLK3, SHBG, PRL
31levonorgestrel46 62 30 1212.3SHBG, SRD5A1, PRL
3217-hydroxyprogesterone46 2510.3SHBG, SRD5A1, PRL
33androstenedione46 2510.3SRD5A1, SHBG, PRL
34leuprolide46 62 30 1212.2SRD5A1, PRL, KLK3
35progestin469.2SHBG, PRL, SRD5A1
36estrone46 30 25 1212.2SRD5A1, PRL, SHBG
37hydrocortisone46 3 62 1212.2SHBG, KLK3, PRL
38thyroxine46 2510.1PRL, SHBG, KLK3
39calcitriol46 62 25 1212.1KLK3, SHBG, SRD5A1
40lanreotide46 3010.0PRL, KLK3
41cyproteroneacetate468.8SRD5A1, KLK3, SHBG, PRL
42flutamide46 62 1210.8SHBG, SRD5A1, KLK3, PRL
43dehydroepiandrosterone sulfate468.8PRL, SRD5A1, SHBG, KLK3
44dhea468.8SRD5A1, SHBG, KLK3, PRL
45dihydrotestosterone46 30 25 1211.8KLK3, SRD5A1, PRL, SHBG
46gnrh468.8KLK3, PRL, SHBG, SRD5A1
47estradiol46 25 1210.7PRL, KLK3, SHBG, SRD5A1
48testosterone46 62 25 1211.6KLK3, SHBG, PRL, SRD5A1
49steroid468.6SHBG, KLK3, PRL, SRD5A1
50dexamethasone46 52 30 1211.6PRL, KLK3, SRD5A1, SHBG

GO Terms for genes affiliated with Androgenic Alopecia

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Products for genes affiliated with Androgenic Alopecia

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Sources for Androgenic Alopecia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet