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MCID: ANM004

Anemia malady
7 drugs, 908 genes, 29 tissues, 1173 related diseases, 29 phenotypes, 2322 articles, clinical trials.

Summaries for Anemia

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23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: If you have anemia, your blood does not carry enough oxygen to the rest of your body. the most common cause of anemia is not having enough iron. your body needs iron to make hemoglobin. hemoglobin is an iron-rich protein that gives the red color to blood. it carries oxygen from the lungs to the rest of the body. your iron might be too low because of heavy periods pregnancy ulcers colon polyps or colon cancer inherited disorders a diet that does not have enough iron, folic acid or vitamin b 12 blood disorders such as sickle cell anemia and thalassemia, or cancer aplastic anemia, a condition that can be inherited or acquired anemia can make you feel weak, cold, dizzy and irritable. it is confirmed with a blood test. treatment depends on the kind of anemia you have. nih: national heart, lung, and blood institute23

MalaCards: Anemia, also known as deficiency anemias nos (disorder), is related to carcinoma and leukemia. An important gene associated with Anemia is FANCA (Fanconi anemia, complementation group A), and among its related pathways are Measles and Metabolic pathways. The drugs nandrolone and oxymetholone and the compounds atp and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Wikipedia: Anemia (/əˈniːmiə/; also spelled anaemia and anæmia; from Ancient Greek: ἀναιμία anaimia,...44 more...

Aliases & Descriptions for Anemia

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6Disease Ontology, 7diseasecard, 44Wikipedia, 17Genetics Home Reference, 8DISEASES, 32Novoseek , 23MedlinePlus, 2CDC, 43UMLS, 40SNOMED-CT, 19ICD9CM, 24MeSH, 27NCIt
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Aliases & Descriptions:

anemia 6 7 44 17 8 32 23 43
deficiency anemias nos (disorder) 6
deficiency anemias (disorder) 6
unspecified deficiency anemia 6
deficiency anemias 43
deficiency anemia 6

Related Diseases for Anemia

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13GeneCards, 14GeneDecks
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Diseases related to anemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1170)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma111.2PIM1, NCOR1, PDCD1, RELA, REN, REV1
2leukemia108.0PIGA, PIM1, SH2D1A, KLF1, KLF2, RFX1
3prostatitis94.4ZNF200, PIM1, NCOR1, PDCD1, RELA, SGCB
4pancreatitis86.7PIM1, NDFIP2, RELA, REN, SGCB, SGK1
5adenocarcinoma77.1ZNF24, PIM1, RFX1, RELA, REV1, KIT
6melanoma75.0PIM1, PDCD1, RELA, KIT, KITLG, VWF
7hepatocellular carcinoma74.9PDCD1, RELA, KIT, VWF, RCHY1, PCNA
8hypoxia72.8PIM1, KLF1, KLF2, RELA, REN, KIT
9myeloma69.0RELA, SGK1, KIT, KITLG, VWF, PCNA
10diabetes mellitus68.7PDCD1, REN, SGCB, SGK1, VWF, GCLC
11gastric cancer68.5ZNF789, PIM1, RELA, KIT, VWF, PCNA
12myeloid leukemia68.4PIM1, KLF1, KLF2, NCOR1, PDCD1, RELA
13thyroiditis68.0KLF1, NCOR1, RELA, REN, KIT, KITLG
14lupus erythematosus67.3PDCD1, VWF, PCNA, NBN, SELE, SELL
15cerebritis66.7NDFIP1, RELA, REN, SGCB, SGK1, KITLG
16tuberculosis65.2PIM1, SH2D1A, PDCD1, RELA, REV1, SFPQ
17colon cancer65.2RELA, VWF, PCNA, GCLC, RB1, SELE
18hypertension65.0PIM1, NDFIP2, REN, SGCB, SGK1, KIT
19cervicitis64.7PDCD1, RELA, REN, REV1, KIT, KITLG
20multiple myeloma63.6RELA, KIT, KITLG, VWF, PCNA, RB1
21lymphocytic leukemia63.5RELA, REV1, KIT, KITLG, RB1, NBN
22pneumonia61.2RELA, REV1, SELE, SELL, SERPINC1, NAGLU
23sarcoma61.2RELA, REN, KIT, KITLG, VWF, SFPQ
24nephropathy61.0PDCD1, RELA, REN, SGK1, KITLG, VWF
25lymphoblastic leukemia59.7RELA, KIT, KITLG, VWF, PCNA, RB1
26peritonitis57.8RELA, REN, SGK1, KIT, KITLG, VWF
27ischemia57.7NDFIP1, RELA, REN, SGCB, SGK1, KITLG
28acute myeloid leukemia57.6PIM1, KLF1, NCOR1, RELA, REN, CNTRL
29obesity57.3RELA, REN, SGK1, VWF, PCNA, SELE
30myocardial infarction56.5PDCD1, REN, SGCB, KITLG, VWF, GCLC
31ataxia56.2ZNF276, NCOR1, VWF, RCHY1, PCNA, NBN
32sickle cell anemia55.9KLF2, RFX1, RELA, KITLG, VWF, RBM17
33thalassemia53.6KLF1, VWF, SELE, SERPINC1, NAGLU, VDR
34cervical cancer53.4PDCD1, RELA, PCNA, RB1, SERPINC1, BRCA1
35neuronitis52.7PIM1, SH2D1A, NDFIP1, RFX1, NCOR1, RELA
36squamous cell carcinoma52.4PIM1, RELA, SGCB, PCNA, RB1, NBN
37blindness52.0REN, VWF, SELE, SELP, SERPINC1, VEGFA
38acute leukemia51.9NCOR1, REN, KIT, KITLG, VWF, RB1
39neuropathy51.7REN, VWF, SELE, SERPING1, NAGLU, VEGFA
40thrombocytopenia51.4PIGA, KLF1, KITLG, VWF, SELE, SELL
41glomerulonephritis51.0REN, SGK1, KIT, KITLG, VWF, PCNA
42sickle cell disease50.4KLF1, VWF, SELE, SELL, SELP, BRCA1
43colon carcinoma49.8KIT, KITLG, SELE, SELL, SELP, BRCA1
44hemolytic anemia49.2PIGA, VWF, GCLC, UGT1A1, LCAT, LACTB
45thrombosis49.0PIGA, REN, VWF, PCNA, SELE, SELL
46hematopoiesis48.5PIGA, PIM1, REN, KIT, KITLG, SFXN1
47aplastic anemia48.1PIGA, SH2D1A, KITLG, NBN, SBDS, MPL
48diamond-blackfan anemia47.7PIM1, KITLG, RAN, UNC45A, KCNN4, MTHFR
49purpura47.7VWF, SELE, SELP, SERPINC1, VEGFA, VCAM1
50endometriosis47.1NCOR1, RELA, KITLG, PCNA, SERPINC1, BRCA1

Graphical network of the top 20 diseases related to anemia:



Graphical network of diseases related to anemia

Clinical Features for Anemia

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Drugs & Therapeutics for Anemia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 darbepoetin alfa,recombinant, epoetin alfa,recombinant, nandrolone, nandrolone decanoate, nandrolone phenpropionate, oxymetholone, sodium ascorbate

Genetic Tests for Anemia

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Anatomical Context for Anemia

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22MalaCards
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MalaCards organs/tissues related to anemia:

22
Bone marrow, Whole blood, Spleen, Thymus, Brain, Heart, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Prostate, Testis, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Testis germ

Phenotypes for genes affiliated with Anemia

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25MGI
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MGI Mouse Phenotypes related to anemia:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1limbs/digits/tail phenotypeMP:0005371INFNDFIP1, RELA, , KITLG, RB1, BRCA1
2craniofacial phenotypeMP:0005382INFPIGA, KLF2, , KITLG, NBN, SEC23B
3cellular phenotypeMP:0005384INFZNF24, PIGA, PIM1, SH2D1A, KLF2, NDFIP1
4pigmentation phenotypeMP:0001186INF, KITLG, RB1, SERPINC1, NAGLU, BRCA1
5cardiovascular system phenotypeMP:0005385INFKLF2, PDCD1, RELA, REN, SGCB,
6growth/size phenotypeMP:0005378INFPIGA, PIM1, KLF2, NDFIP1, NCOR1, RELA
7hearing/vestibular/ear phenotypeMP:0005377INF, KITLG, RB1, SEC24B, NAGLU, VDR
8mortality/agingMP:0010768INFZNF24, PIGA, KLF1, KLF2, NDFIP1, RFX1
9integument phenotypeMP:0010771INFPIGA, KLF1, NDFIP1, NCOR1, RELA,
10liver/biliary system phenotypeMP:0005370INFKLF1, KLF2, NDFIP1, NCOR1, , GCLC
11digestive/alimentary phenotypeMP:0005381INFPIGA, , KITLG, VWF, RB1, SEC23B
12vision/eye phenotypeMP:0005391INFPDCD1, RELA, , KITLG, RB1, SEC24B
13renal/urinary system phenotypeMP:0005367INFKLF1, PDCD1, REN, SGK1, , SELP
14tumorigenesisMP:0002006INFPIGA, , KITLG, RB1, NBN, SELL
15homeostasis/metabolism phenotypeMP:0005376INFKLF1, KLF2, NDFIP1, NCOR1, RELA, REN
16reproductive system phenotypeMP:0005389INFPIGA, REN, NBN, BRCA1, BRCA2, VHL
17respiratory system phenotypeMP:0005388INFKLF2, NDFIP1, SEC24B, SELL, SELP, SEC23B
18immune system phenotypeMP:0005387INFSH2D1A, KLF1, KLF2, NDFIP1, NCOR1, REN
19hematopoietic system phenotypeMP:0005397INFPIGA, PIM1, SH2D1A, KLF1, KLF2, NDFIP1
20nervous system phenotypeMP:0003631INFZNF24, PIGA, NDFIP1, NCOR1, PDCD1, RELA
21muscle phenotypeMP:0005369INFKLF2, NCOR1, PDCD1, RELA, REN, SGCB
22skeleton phenotypeMP:0005390INFPIGA, KLF2, RELA, , KITLG, RB1
23no phenotypic analysisMP:0003012INFSGK1, PCNA, RB1, VEGFA, VCAM1, MYC
24embryogenesis phenotypeMP:0005380INFZNF24, PIGA, KLF1, KLF2, NCOR1,
25behavior/neurological phenotypeMP:0005386INFZNF24, PIGA, NCOR1, REN, , RB1
26adipose tissue phenotypeMP:0005375INFNCOR1, RB1, BRCA1, LMNA, MYC, LIF
27endocrine/exocrine gland phenotypeMP:0005379INFNDFIP1, NBN, SELL, SEC23B, BRCA1, BRCA2
28normal phenotypeMP:0002873INFKLF2, RELA, REN, REV1, , GCLC
29other phenotypeMP:0005395INFRARB, CLU, PBX1, KDR, LDLR, ATP7B

Publications for genes affiliated with Anemia

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35PubMed
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Articles related to anemia:

(show top 50)    (show all 2322)
idTitleAuthorsYearAffiliating Genes
1Can mutations in the ribosomal protein S26 (RPS26) ge ne lead to Klippel-Feil syndrome in Diamond-Blackfan anemia patients? An update from the Czech Diamond-Blackfan Anemia registry. (21414820)Cmejla R.... Pospisilova D.2011RPS26
2Bone marrow microenvironment in fanconi anemia: a pro spective functional study in a cohort of fanconi anemia patients. (19572808)Lecourt S.... Larghero J.2010FANCD2
3Fanconi anemia complementation group FANCD2 protein s erine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction. (19861535)Zhi G.... Kupfer G.M.2009CHEK1, BRCA2, FANCL
4Characterization of myelodysplastic syndrome and aplastic anemia by immunostaining of p53 and hemoglobin F and karyotype analysis: differential diagnosis between refractory anemia and aplastic anemia. (18477214)Iwasaki T.... Murate T.2008TP53, FHQTL
5Candidate gene mutation analysis in idiopathic acquired sideroblastic anemia (refractory anemia with ringed sideroblasts). (16870250)Steensma D.P.... Lasho T.L.2007FECH, ABCB7, PUS1
6Impact of an anemia clinic on emergency room visits a nd hospitalizations in patients with anemia of CKD pre-dialysis. (17486947)Perkins R.... Lebrun C.2007EPO
7Pyruvate kinase deficient hemolytic anemia in the Northern Irish population. (17574881)Percy M.J.... McMullin M.F.2007PKLR
8Prevalence and correlates of anemia and uncontrolled anemia in chronic hemodialysis patients--the Campania Dialysis Registry. (17520570)Di Iorio B.... De Santo N.G.2007ALB
9Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. (17161060)Palazzuoli A.... Nuti R.2006EPO
10Anemia, chronic renal disease and congestive heart fa ilure--the cardio renal anemia syndrome: the need for cooperation between cardi ologists and nephrologists. (16868702)Silverberg D.S.... Schwartz D.2006EPO
11The incidence of anemia in an Israeli population: a population analysis for anemia in 34,512 Israeli infants aged 9 to 18 months. (16940163)Meyerovitch J.... Koren A.2006TTF2
12High frequency of several PIG-A mutations in patients with aplastic anemia and myelodysplastic syndrome. (16467865)Okamoto M.... Maruyama Y.2006PIGA
13Erythropoietin is approved for the treatment of anemia associated with renal failure, chemotherapy, preoperative anemia, and human immunodeficiency virus disease. (15719399)Savur S.... Osorio R.2005EPO
14Unraveling the structural and functional features of an aldolase A mutant involved in the hemolytic anemia and severe rhabdomyolysis reported in a child. (15632214)Esposito G.... Salvatore F.2005ALDOA
15Therapy insight: congestive heart failure, chronic ki dney disease and anemia, the cardio-renal-anemia syndrome. (16265380)Iaina A.... Wexler D.2005EPO
16Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis. (15843240)Margetic S.... Kvaternik M.2005TFRC
17The role of anemia in the progression of congestive heart failure. Is there a place for erythropoietin and intravenous iron? (15593047)Silverberg D.S.... Iaina A.2004IL6, EPO
18Anemia with chronic renal disorder and disrupted metabolism of erythropoietin in ICR-derived glomerulonephritis (ICGN) mice. (15133273)Yamaguchi-Yamada M.... Miyamoto H.2004TF, EPO
19Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. (12393428)Weinstein D.A.... Andrews N.C.2002HAMP
20Anemia and the liver. Hepatobiliary manifestations of anemia. (12516198)Edwards C.Q.2002G6PD
21Long-term follow-up of patients with aplastic anemia and refractory anemia responding to combination therapy with recombinant human granulocyte colony-stimulating factor and erythropoietin. (12416735)Matsuda A.... Bessho M.2002EPO
22Aplastic anemia evolving into overt myelodysplastic syndrome/acute myeloid leukemia with t(3;5)(p25;q31). (12393278)Kawata E.... Yoshikawa T.2002CSF3
23Stem cell defect in aplastic anemia: reduced long term culture-initiating cells (LTC-IC) in CD34+ cells isolated from aplastic anemia patient bone marrow. (12391540)Rizzo S.... Gibson F.M.2002CD34
24Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells. (11750104)Siddique M.A.... D'Andrea A.D.2001FANCC, FANCA, FANCG
25Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs transferrin receptor concentration. (11190796)Wians F.H.... Kroft S.H.2001TF, TFRC
26N-RAS gene mutation in patients with aplastic anemia and aplastic anemia/ paroxysmal nocturnal hemoglobinuria during evolution to clonal disease. (10627475)Mortazavi Y.... Rutherford T.R.2000NRAS, PIGA
27Serum leptin levels in patients with sideropenic and pernicious anemia: the influence of anemia treatment. (11252534)Markova M.... Haas T.2000LSL
28The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex. (11050007)Garcia-Higuera I.... D'Andrea A.D.2000FANCA, FANCG
29Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italiano Trapianti di Midolio Osseo (GITMO). (10706857)Bacigalupo A.... Ferster A.2000CSF3
30Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. (11110674)Faivre L.... Mathew C.G.2000FANCG
31Reticulocyte analysis in iron deficiency anemia and hemolytic anemia. (10865417)Butthep P.... Bunyaratvej A.2000G6PD
32Several mutations including two novel mutations of the glucose-6-phosphate dehydrogenase gene in Polish G6PD deficient subjects with chronic nonspherocytic hemolytic anemia, acute hemolytic anemia, and favism. (10571945)Jablonska-Skwiecinska E.... Burzynska B.1999G6PD
33Anemia and its treatment with peroral anti-anemia ag ents in women during the postpartum period (10568044)MA!ra M.... MA!rovA! E.1999TFRC
34Effect of androgen therapy and anemia on serum erythropoietin levels in patients with aplastic anemia and myelodysplastic syndromes. (9462542)Piedras J.... LA^pez-Karpovitch X.1998EPO
35Sideroblastic anemias: variations on imprecision in diagnostic criteria, proposal for an extended classification of sideroblastic anemias. (9423809)Koc S.... Harris J.W.1998ALAS2
36Treatment of the anemia of aplastic anemia patients with recombinant human erythropoietin in combination with granulocyte colony-stimulating factor: a multicenter randomized controlled study. Multicenter Study Group. (9186538)Bessho M.... Kohgo Y.1997CSF3, EPO
37Clinical variability of Fanconi anemia (type C) resul ts from expression of an amino terminal truncated Fanconi anemia complementatio n group C polypeptide with partial activity. (8639804)Yamashita T.... D'Andrea A.D.1996FANCC
38Late-onset X-linked sideroblastic anemia. Missense mutations in the erythroid delta-aminolevulinate synthase (ALAS2) gene in two pyridoxine-responsive patients initially diagnosed with acquired refractory anemia and ringed sideroblasts. (7560104)Cotter P.D.... Bishop D.F.1995ALAS2
39Cardiac hemolysis and anemia refractory to erythropoietin: on anemia in dialysis patients. (8538832)Evers J.1995EPO
40Serum erythropoietin levels in patients with severe anemia secondary to inflammatory bowel disease and the use of recombinant human erythropoietin in patients with anemia refractory to treatment. (7634987)DemirtA1rk L.... Ozel M.1995EPO
41Recombinant human erythropoietin in the anemia associated with multiple myeloma or non-Hodgkin's lymphoma: dose finding and identification of predictors of response. (8541533)Cazzola M.... Ehmer B.1995EPO
42Erythropoietin in the treatment of iron overload in a patient with hemolytic anemia and pyruvate kinase deficiency. (7976118)Vukelja S.J.1994EPO
43Trilineage recovery by combination therapy with recombinant human granulocyte colony-stimulating factor and erythropoietin in patients with aplastic anemia and refractory anemia. (7533579)Bessho M.... Kusumoto S.1994EPO
44Combination therapy with rhGM-CSF and rhEpo for two patients with refractory anemia and aplastic anemia. (8244908)Takahashi M.... Shibata A.1993EPO
45Serum erythropoietin levels in elderly inpatients with anemia of chronic disorders and iron deficiency anemia. (8227911)Joosten E.... Pelemans W.1993EPO
46Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. (1583389)Ferguson B.J.... Cook J.D.1992TFRC
47Improvement in anemia by recombinant human erythropoietin in patients with myelodysplastic syndrome and aplastic anemia. (2040187)Hirashima K.... Jinnai I.1991EPO
48Remarkable improvement of anemia by administration of recombinant human erythropoietin in a patient with aplastic anemia (1942534)Misago M.... Eto S.1991EPO
49Suppressed serum erythropoietin response to anemia and the efficacy of recombinant erythropoietin in the anemia of rheumatoid arthritis. (2213753)Takashina N.... Kashiwazaki S.1990EPO
50Improvement of anemia by recombinant erythropoietin in patients with myelodysplastic syndromes and aplastic anemia. (2273298)Bessho M.... Hirashima K.1990EPO

Expression for genes affiliated with Anemia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Anemia

Pathways for genes affiliated with Anemia

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20KEGG, 36QIAGEN, 3Cell Signaling Technology, 41Thomson Reuters, 38Reactome
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Pathways related to anemia according to GeneDecks:

(show top 50)    (show all 138)
idPathwayScoreTop Affiliating Genes
1Measles20INFSH2D1A, RELA, RCHY1, CHUK, MX1, MSN
2Metabolic pathways20INFPIGA, GCLC, GCLM, NAGLU, BPGM, LIPG
3Jak-STAT signaling pathway20INFPIM1, MYC, LEP, MPL, JAK2, IL10
4p53 Mediated Apoptosis36INF, KITLG, BMP2, BMP6, BMP7, KDR
5Antioxidant Action of Vitamin-C36INF, KITLG, BMP2, BMP6, BMP7, BMPR1A
6Pathways in cancer20INFRELA, RB1, BRCA2, VEGFA, MYC, BMP2
7ERK Signaling36INF, KITLG, MYC, BMP2, BMP6, BMP7
8Cellular Apoptosis Pathway36INF, KITLG, BMP2, BMP6, BMP7, KDR
9Endothelin-1 Signaling Pathway36INF, MYC, BMP2, BMP6, BMP7, FLT3
10p70S6K Signaling36INF, KITLG, BMP2, BMP6, BMP7, KDR
11JNK Pathway36INF, KITLG, BMP2, BMP6, BMP7, KDR
12Hematopoietic cell lineage20INF, KITLG, CD59, CD34, CD44, CD9
13PAK Pathway36INF, KITLG, BMP2, BMP6, BMP7, LIF
14Telomerase Components in Cell Signaling36INF, KITLG, RB1, MYC, BMP2, BMP6
15p38 Signaling36INF, KITLG, BMP2, BMP6, BMP7, BMPR1A
16Cytokine-cytokine receptor interaction20INF, KITLG, VEGFA, BMP2, BMP7, BMPR1A
17Tec Kinases Signaling36INFKITLG, BMP2, BMP6, BMP7, BMPR1A, BCL2
18Cell Cycle / Checkpoint Control3INFRCHY1, PCNA, RB1, NBN, BRCA1, BRCA2
19Rho Family GTPases36INF, KITLG, BMP2, BMP6, BMP7, LIF
20Lymphocyte Signaling3INFPIM1, SH2D1A, , KITLG, PBX1, LCK
21JAK-STAT Pathway36INF, KITLG, BRCA1, MYC, BMP2, BMP6
22Ribosome2015.3RSL24D1, RPS6, RPS3A, RPS21, RPS26, RPL18
23CFTR translational fidelity (class I mutations)4115.0RPS6, RPS3A, RPS21, RPS26, RPL18, RPL35
24DNA Repair Mechanisms3614.9PCNA, BRCA1, BRCA2, RAD51, RAD50, LIG4
25STAT3 Pathway3614.7PIM1, MYC, BMP2, BMP6, BMP7, BMPR1A
26BRCA1 Pathway3614.5RB1, BRCA1, BRCA2, RAD51, RAD50, BLM
27Influenza A2014.1RELA, MX1, XPO1, ATF2, JAK2, IL12A
28Glucocorticoid Receptor Signaling3614.1NCOR1, BMP2, BMP6, BMP7, BCL2, CDKN1A
29PEDF Induced Signaling3614.1RELA, BMP2, BMP6, BMP7, LIF, BCL2
30MIF Regulation of Innate Immune Cells3613.8BMP2, BMP6, BMP7, LIF, BCL2, MIF
31Malaria2013.6SELE, SELP, VCAM1, CD40LG, GYPA, GYPB
32Metabolism of mRNA3813.6RPS6, RPS3A, RPS21, RPS26, RPS18, RPS2
33MIF Mediated Glucocorticoid Regulation3613.6BMP2, BMP6, BMP7, LIF, BCL2, MIF
34SOCS Pathway3613.5BMP2, BMP6, BMP7, BCL2, UBE2A, JAK2
35Fanconi Anemia pathway3813.4USP1, PALB2, ZBTB32, UBE2T, FANCD2, FANCA
36IL-6 Pathway3613.3PIM1, BMP2, BMP6, BMP7, GRB2, IL10
37Regulation of eIF4 and p70S6K3613.3BMP2, ITGA2, ITGA2B, ITGA4, ITGA5, ITGB3
38Fanconis Anaemia Pathway3613.1BRCA1, BRCA2, RAD51, RAD50, UBB, UBC
39RAR-Gamma-RXR-Alpha Degradation3613.1BMP2, BMP7, LIF, UBB, UBC, UBR1
40all-trans-Retinoic Acid Signaling in Brain3613.0BMP2, BMP6, BMP7, RARB, LIF, BCL2
41Cytokine Network3612.7IL10, IL12A, IL12B, IL13, IL15, IL18
42Metabolism of RNA3812.4RPL18, RPL35, RPL6, RPL27, RPL9, RPL26
43PGC1Alpha Pathway3612.3BMP2, BMP6, BMP7, BCL2, IL11, IL12A
44Molecular Mechanisms of Cancer36INFKITLG, RB1, BRCA1, MYC, BMP2, BMP6
45Akt Signaling36INF, BMP2, BMP7, BMPR1A, LIF, CHEK1
46TGF-Beta Pathway36INFKITLG, BMP2, BMP6, BMP7, KDR, BCL2
47Pancreatic Adenocarcinoma36INF, KITLG, RB1, BRCA2, BMP2, BMP6
48Chagas disease (American trypanosomiasis)20INFRELA, CHUK, IL10, IL12A, IL12B, IL1B
49MAPK Family Pathway36INFKITLG, BMP2, BMP6, BMP7, KDR, BCL2
50DNA Damage3INFNBN, BRCA1, BRCA2, RAD50, RAD18, USP1

Compounds for genes affiliated with Anemia

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
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Compounds related to anemia according to GeneDecks:

(show top 50)    (show all 515)
idCompoundScoreTop Affiliating Genes
1atp32 INFPIM1, SGCB, , RB1, BRCA1, LMNA
2acetylcholine32 9 18 9 INFSGCB, VWF, BMP6, UTRN, LIF, BLZF1
3cholesterol32 9 18 9 INFREN, KITLG, VWF, RB1, SELE, SELP
4superoxide32 18 INFSGCB, KITLG, RB1, SELL, NAGLU, VCAM1
5agar32 INFKITLG, RB1, BRCA1, RARB, RASSF1, LACTB
6phosphotyrosine32 INFSH2D1A, , BRCA1, UTRN, BLZF1, KDR
7estradiol32 9 18 9 INFNCOR1, REN, KITLG, PCNA, RB1, BRCA1
8nitric oxide32 9 18 9 INFKLF2, REN, SGCB, , KITLG, GCLM
9paraffin32 INFRELA, , KITLG, VWF, PCNA, RB1
10calcitriol32 42 9 18 9 INFREN, KITLG, RB1, VDR, MYC, BMP2
11gemcitabine32 34 9 9 INFPCNA, BRCA1, VEGFA, BNIP3, MYC, RAD51
12lactate32 INF, KITLG, VWF, PCNA, SELE, SELL
13polyacrylamide32 INFRB1, BRCA1, BRCA2, BMP2, RAD51, BLZF1
145fluorouracil32 INF, KITLG, PCNA, RB1, SELE, BRCA1
15agarose32 INF, KITLG, VWF, BRCA1, MYC, BMP7
16chloroquine32 34 9 9 INF, SERPINC1, BRCA1, BMP6, LDLR, B2M
17actinomycin d32 INFSGK1, , KITLG, RB1, SELE, VHL
18docetaxel32 34 9 9 INF, BRCA1, BRCA2, VEGFA, VDR, MYC
19homocysteine32 18 INFVWF, SELE, SELP, SERPINC1, NAGLU, VCAM1
20ganciclovir32 9 9 INFKITLG, BMP6, KDR, LEP, , CD9
21mannitol32 9 9 INFSGK1, SELP, NAGLU, VCAM1, SDHB, SCT
22cocaine32 9 9 INFSELE, SELP, VCAM1, BMP6, LEP, S100B
23manganese superoxide32 13.6VCAM1, ATM, GSR, GSTM1, GSTP1, GSTT1
24methylmethanesulfonate32 13.3PCNA, NBN, BRCA1, BRCA2, RAD51, RAD50
25methacholine32 9 9 15.0REN, MPO, CD79A, ITGA4, IL13, IL17A
26poly(i-c)32 12.9VCAM1, CHUK, MX1, IRF1, IL12B, IL15
27il 1032 12.7VDR, BMP6, LIF, IL10, IL12B, IL13
28il-1232 12.3CD40LG, IL10, IL12B, IL13, IL15, IL18
29dextran sulfate32 INFSELE, SELL, SELP, SERPINC1, LDLR, MPO
30carbon32 INFVWF, PCNA, VDR, LDLR, MTHFR, MTR
31p00332 INF, RB1, BRCA1, BRCA2, RASSF1, LEP
32leucovorin32 34 9 9 INFVEGFA, UMPS, UGT1A1, CEACAM5, FTCD, IL15
33aprotinin32 9 9 INFVWF, SELP, SERPINC1, NAGLU, FN1, IL1A
34geldanamycin32 9 9 INFPIM1, VEGFA, PARP1, PARK2, KDR, LCK
35hydroxyurea32 9 9 INF, KITLG, PCNA, NBN, SELL, BRCA1
36dopamine32 9 18 9 INFREN, SELE, NAGLU, BMP2, BMP6, RARB
37troglitazone32 42 9 9 INFRB1, SELE, VDR, VCAM1, BMP6, BCL2
38tgf beta132 INFKITLG, VCAM1, BMP2, BMP6, BMP7, LIF
39adenine32 9 18 9 INFVWF, BRCA1, MYB, RAD51, LEP, UGT1A1
40iron32 18 INFSGCB, KITLG, SFXN1, SFXN2, SFXN4, NAGLU
41glucose32 INF, VHL, LMAN1, BNIP3, BMP7, PARK2
42glyceraldehyde 3-phosphate32 INFBLZF1, CLU, SDHB, MX1, B2M, CEACAM5
43glycerol32 9 18 9 INFVWF, PCNA, SERPINC1, BRCA1, LEP, CHUK
44aphidicolin32 INFPCNA, RB1, BRCA1, MYC, RAD51, LIG1
45vitamin-e32 INFNAGLU, VCAM1, B2M, FXN, JAK2, GSR
46matrigel32 INFVWF, RB1, SELE, VEGFA, VCAM1, BMP2
47creatinine32 INFREN, SGK1, KITLG, VWF, PCNA, SELE
48calcium32 9 18 9 INFPIM1, SH2D1A, RELA, REN, SGCB, SGK1
49histidine32 INFKITLG, VHL, BPGM, RAD51, SCT, CHEK1
50cytochalasin d32 42 INFKITLG, VWF, SELE, SELL, VCAM1, BCR

GO Terms for genes affiliated with Anemia

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Sources:
12Gene Ontology
See all sources

Cellular components related to anemia according to GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:005737INFPIM1, SH2D1A, NDFIP2, RELA, SGCB,
2nucleoplasmGO:005654INFNCOR1, RELA, REV1, SF3A1, SF3B1, SF3B4
3cytosolic small ribosomal subunitGO:02262713.6RPS6, RPS3A, RPS21, RPS26, RPS18, RPS2
4Fanconi anaemia nuclear complexGO:04324012.5APITD1, FANCA, FANCL, FANCE, FANCF, FANCC
5cytosolic large ribosomal subunitGO:02262512.4RPL18, RPL35, RPL6, RPL27, RPL9, RPL26
6platelet alpha granule lumenGO:03109312.3VWF, SERPING1, VEGFA, CLU, FN1, IGF1
7chromosome, telomeric regionGO:00078112.0BLM, CHEK1, ATM, MRE11A, ERCC4, TNKS
8SWI/SNF complexGO:01651411.8RB1, ARID1A, SMARCA4, SMARCB1, SMARCC1, SMARCC2
9small ribosomal subunitGO:01593511.8RPS6, RPS21, RPS26, RPS18, RPS28, RPS25
10nBAF complexGO:07156511.3ARID1A, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1
11npBAF complexGO:07156411.2ARID1A, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1
12integral to plasma membraneGO:005887INFSGCB, SELL, SELP, KDR, SCN2A, UGT1A1
13plasma membraneGO:005886INFPIM1, PDCD1, SGK1, , KITLG, VPS28
14extracellular regionGO:005576INFNDFIP1, KITLG, VWF, SERPINC1, SEMG1, SERPING1
15external side of plasma membraneGO:009897INF, VWF, SELL, SELP, VCAM1, KDR
16nucleolusGO:005730INFSF3A1, RCHY1, PCNA, RBM17, NBN, SELP
17cell surfaceGO:009986INFVEGFA, VCAM1, BMP2, USP14, LDLR, MSN
18nucleusGO:005634INFZNF276, ZNF24, ZNF200, ZNF789, PIM1, KLF1
19perinuclear region of cytoplasmGO:048471INFNDFIP1, NDFIP2, SEC24B, SELE, SEC23A, SEC23B
20nuclear chromatinGO:000790INFKLF1, NCOR1, KDM2A, UBE2A, T, MRE11A
21extracellular spaceGO:005615INFREN, , KITLG, SELE, SELP, SERPINC1
22cytosolGO:005829INFRELA, SGOL1, CNTRL, VPS28, GCLC, GCLM

Biological processes related to anemia according to GeneDecks:

(show top 50)    (show all 59)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:044281INFNCOR1, GCLC, GCLM, NAGLU, NAMPT, LPIN2
2positive regulation of tyrosine phosphorylation of Stat3 proteinGO:042517INF, LIF, LEP, JAK2, , IL12B
3apoptotic processGO:006915INFPIM1, PDCD1, SGK1, NBN, BRCA1, LMNA
4leukocyte migrationGO:050900INFSELL, SELP, LCK, MSN, , CD34
5blood coagulationGO:007596INFVWF, SELL, SELP, SERPINC1, SERPING1, VEGFA
6response to drugGO:042493INFREN, GCLM, NBN, MYC, BCL2, UGT1A1
7embryonic hemopoiesisGO:035162INFKLF1, , KITLG, ZFPM1, KDR, FLT3LG
8inflammatory responseGO:006954INFRELA, , SELE, SELP, BMP2, BMP6
9cytokine-mediated signaling pathwayGO:019221INFRELA, , VCAM1, MX1, UBB, UBC
10gene expressionGO:010467INFNCOR1, SF3A1, SF3B1, SF3B4, VDR, MYC
11immune responseGO:006955INFRFX1, BMP6, BMPR1A, LIF, ZEB1, CHUK
12viral reproductionGO:01603217.3ZNF24, VPS28, RAN, LIG4, SCAND3, UBB
13RNA metabolic processGO:01607016.2UBB, UBC, XPO1, MAPK14, HSPA8, AKT1
14mRNA metabolic processGO:01607116.2UBB, UBC, XPO1, MAPK14, HSPA8, AKT1
15translationGO:00641216.1PABPC4, YARS2, MRPL28, AKT1, RPS6, RPS3A
16negative regulation of apoptotic processGO:04306615.6PIM1, RELA, VEGFA, MYC, CLU, PALB2
17viral infectious cycleGO:01905815.6RAN, XPO1, RPS6, RPS3A, RPS21, RPS26
18SRP-dependent cotranslational protein targeting to membraneGO:00661415.4RPS6, RPS3A, RPS21, RPS26, RPL18, RPN2
19translational initiationGO:00641315.4RPS6, RPS3A, RPS21, RPS26, RPL18, RPL35
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:00018415.3RPS6, RPS3A, RPS21, RPS26, RPL18, RPL35
21translational elongationGO:00641415.3RPS6, RPS3A, RPS21, RPS26, RPL18, RPL35
22translational terminationGO:00641515.3RPS6, RPS3A, RPS21, RPS26, RPL18, RPL35
23platelet activationGO:03016815.3VWF, SELP, SERPING1, VEGFA, CLU, LCK
24viral transcriptionGO:01908315.2RPS6, RPS3A, RPS21, RPS26, RPL18, RPL35
25anti-apoptosisGO:00691614.3RELA, GCLC, VHL, BNIP3, BCL2, UBB
26cell proliferationGO:00828313.6PIM1, KITLG, PCNA, NBN, LIG4, LIPG
27platelet degranulationGO:00257613.6VWF, SELP, SERPING1, VEGFA, CLU, CD9
28cell cycle checkpointGO:00007513.4RB1, CLSPN, CHEK1, UBB, UBC, XPC
29positive regulation of peptidyl-tyrosine phosphorylationGO:05073113.1KITLG, VEGFA, LIF, MTOR, JAK2, CD44
30double-strand break repairGO:00630213.0NBN, BRCA1, BRCA2, BRIP1, RAD51, RAD50
31double-strand break repair via homologous recombinationGO:00072412.9NBN, BRCA1, BRCA2, RAD51, RAD50, LIG1
32chromatin remodelingGO:00633812.3KLF1, RB1, BNIP3, MYC, MYB, FOXP3
33telomere maintenanceGO:00072312.1PCNA, NBN, RAD50, LIG1, BLM, PARP1
34positive regulation of cell proliferationGO:008284INF, NBN, NAMPT, VEGFA, MYC, LIF
35virus-host interactionGO:019048INFRELA, RB1, VCAM1, LMBRD1, BNIP3, RAN
36cellular protein metabolic processGO:044267INFPIGA, SEC24B, SEC13, SEC23A, LMAN1, MGAT2
37cellular iron ion homeostasisGO:006879INFNDFIP1, MYC, ATP6V1B1, FXN, FTH1, FTL
38negative regulation of cell proliferationGO:008285INFVHL, VDR, BMP2, RARB, LIF, ZEB1
39DNA repairGO:006281INFREV1, SFPQ, PCNA, NBN, BRCA1, BRCA2
40positive regulation of transcription from RNA polymerase II promoterGO:045944INFKLF2, RELA, RB1, BRCA1, VEGFA, LPIN2
41response to hypoxiaGO:001666INFVEGFA, VCAM1, BNIP3, BMP2, BCL2, LEP
42positive regulation of tyrosine phosphorylation of Stat5 proteinGO:042523INF, JAK2, IL12B, IL2, IL23A, IL23R
43heme biosynthetic processGO:006783INFUROD, , FXN, FECH, ALAD, ALAS1
44hemopoiesisGO:030097INF, KITLG, BRCA2, BCL11A, ZBTB16, ZBTB32
45positive regulation of phosphatidylinositol 3-kinase cascadeGO:014068INF, SELP, KDR, JAK2, FLT3, INS
46response to DNA damage stimulusGO:006974INFSGK1, BRCA1, MYC, RAD50, RASSF1, USP28
47erythrocyte differentiationGO:030218INFKLF1, , SFXN1, ZFPM1, JAK2, FLVCR1
48positive regulation of T cell proliferationGO:042102INFVCAM1, CD28, IL12A, IL12B, IL15, IL1B
49positive regulation of transcription, DNA-dependentGO:045893INFKLF1, KLF2, RELA, RB1, BRCA1, BRCA2
50negative regulation of transcription from RNA polymerase II promoterGO:000122INFNCOR1, VHL, VDR, MYC, MYB, BMP2

Molecular functions related to anemia according to GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1iron ion bindingGO:005506INFLCN2, MTRR, XDH, FTH1, FTL, ISCU
2cytokine activityGO:00512515.1KITLG, NAMPT, VEGFA, BMP2, BMP6, BMP7
3structural constituent of ribosomeGO:00373514.9MRPL28, RPS6, RPS3A, RPS26, RPL18, RPL35
4growth factor activityGO:00808314.0KITLG, VEGFA, BMP2, BMP6, BMP7, LIF
5identical protein bindingGO:04280213.7RELA, PCNA, LMAN1, BNIP3, RAD51, RASSF1
6ubiquitin protein ligase bindingGO:03162513.5RELA, RB1, BRCA1, RAD18, BLZF1, CLU
7protein N-terminus bindingGO:04748512.6RELA, VWF, NBN, RASSF1, PARP1, ATM
8single-stranded DNA bindingGO:00369711.4BRCA2, RAD51, RAD23A, BLM, YBX1, XPC
9ATP bindingGO:005524INFPIM1, SGK1, , GCLC, BRIP1, BMPR1A
10transcription factor bindingGO:008134INFPIM1, RELA, RB1, NBN, VHL, MYC
11protein bindingGO:005515INFZNF24, PIGA, PIM1, NDFIP1, NDFIP2, RFX1
12protein homodimerization activityGO:042803INF, VWF, RCHY1, VEGFA, BNIP3, BMP2
13RNA bindingGO:003723INFSF3A1, SF3B4, SFPQ, RBM17, BRCA1, CHERP
14transcription regulatory region DNA bindingGO:044212INFKLF1, NCOR1, RELA, BRCA1, XRCC6, CDK9
15heme bindingGO:020037INFMPO, JAK2, FECH, MB, CAT, HMOX1

Sources for Anemia

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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