MCID: ANM001
MIFTS: 43

Anemia of Prematurity

Categories: Fetal diseases, Blood diseases

Aliases & Classifications for Anemia of Prematurity

MalaCards integrated aliases for Anemia of Prematurity:

Name: Anemia of Prematurity 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:11243
ICD10 32 P61.2
ICD9CM 34 776.6
NCIt 46 C97167
SNOMED-CT 64 47100003
UMLS 69 C0158996

Summaries for Anemia of Prematurity

MalaCards based summary : Anemia of Prematurity is related to deficiency anemia and acquired polycythemia. An important gene associated with Anemia of Prematurity is EPO (Erythropoietin), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Darbepoetin alfa and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include brain, neutrophil and heart, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 72 Anemia of prematurity refers to a form of anemia affecting preterm infants with decreased... more...

Related Diseases for Anemia of Prematurity

Diseases related to Anemia of Prematurity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 28.5 CSF3 EPO EPOR HAMP IL3
2 acquired polycythemia 10.5 EPO EPOR
3 seborrheic infantile dermatitis 10.5 CSF2 IL3
4 erythrocytosis, familial, 2 10.4 EPO EPOR
5 retinitis pigmentosa and erythrocytic microcytosis 10.4 EPO IL3
6 transient erythroblastopenia of childhood 10.4 EPO KITLG
7 neonatal anemia 10.4 EPO EPOR
8 acute monoblastic leukemia 10.3 CSF2 EPO
9 large granular lymphocyte leukemia 10.3 CSF2 STAT5B
10 primary polycythemia 10.3 EPO EPOR IL3
11 thrombocytosis 10.3 CSF2 EPO IL3
12 eosinophilic gastroenteritis 10.2 CSF2 IL3
13 megakaryocytic leukemia 10.2 CSF2 IL3 KITLG
14 b cell linker protein deficiency 10.1 STAT5A STAT5B
15 cellular congenital mesoblastic nephroma 10.1 STAT5A STAT5B
16 engraftment syndrome 10.0 CSF2 CSF3
17 human t-cell leukemia virus type 2 10.0 CSF2 STAT5A
18 jak3-deficient severe combined immunodeficiency 10.0 STAT5A STAT5B
19 trichosporonosis 10.0 CSF2 CSF3
20 refractory anemia 10.0 EPO IL3
21 pancytopenia 9.9 CSF2 CSF3 EPO
22 doxorubicin induced cardiomyopathy 9.9 CSF3 EPOR
23 felty syndrome 9.9 CSF2 CSF3 IL3
24 cyclic neutropenia 9.9 CSF2 CSF3 IL3
25 granulocytopenia 9.9 CSF2 CSF3 IL3
26 lymphoma, hodgkin, classic 9.8 CSF2 CSF3 IL3
27 dyskeratosis congenita 9.8 CSF2 CSF3 EPO
28 polycythemia 9.7 EPO EPOR IL3 KITLG STAT5A
29 ewing's family of tumors 9.7 CSF3 EPO EPOR KITLG
30 diamond-blackfan anemia 9.7 CSF2 EPO EPOR GYPA IL3 KITLG
31 erythrocytosis, familial, 1 9.6 EPO EPOR IL3 STAT5A STAT5B
32 leukocyte disease 9.6 CSF2 CSF3 IL3 KITLG
33 essential thrombocythemia 9.6 EPO EPOR IL3 STAT5A STAT5B
34 severe congenital neutropenia 9.6 CSF2 CSF3 IL3 KITLG
35 enterocolitis 9.6
36 autoinflammation with infantile enterocolitis 9.6
37 bronchopulmonary dysplasia 9.6
38 iron deficiency anemia 9.6
39 iron metabolism disease 9.6
40 ischemia 9.6
41 perinatal necrotizing enterocolitis 9.6
42 neutropenia 9.5 CSF2 CSF3 IL3
43 aplastic anemia 9.4 CSF2 CSF3 EPO IL3 KITLG
44 immune system disease 9.4 CSF2 CSF3 EPO HAMP IL3
45 polycythemia vera 9.4 EPO EPOR IL3 KITLG STAT5A STAT5B
46 asthma 9.3 CSF2 CSF3 IL3 KITLG PTGDR
47 hematologic cancer 9.3 CSF2 CSF3 IL3 KITLG STAT5B
48 myelofibrosis 9.2 CSF3 EPO IL3 STAT5A STAT5B
49 malaria 9.1 CSF2 CSF3 EPO GYPA HAMP SLC4A1
50 myelodysplastic syndrome 8.9 CSF2 CSF3 EPO EPOR IL3 KITLG

Graphical network of the top 20 diseases related to Anemia of Prematurity:



Diseases related to Anemia of Prematurity

Symptoms & Phenotypes for Anemia of Prematurity

MGI Mouse Phenotypes related to Anemia of Prematurity:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 STAB2 STAT5A STAT5B SLC7A11 CSF2 HIF1AN
2 hematopoietic system MP:0005397 10.11 SLC7A11 STAT5A STAT5B GPX3 CSF2 KITLG
3 cellular MP:0005384 10.1 SLC7A11 STAT5A STAT5B SLC4A1 HIF1AN CSF2
4 cardiovascular system MP:0005385 10.09 STAB2 SLC4A1 GPX3 HIF1AN CSF2 KITLG
5 immune system MP:0005387 9.96 SLC7A11 STAT5A STAT5B SLC4A1 CSF2 KITLG
6 integument MP:0010771 9.81 SLC7A11 STAT5A STAT5B CSF2 KITLG CSF3
7 liver/biliary system MP:0005370 9.56 STAB2 STAT5A STAT5B HIF1AN KITLG EPO
8 mortality/aging MP:0010768 9.36 STAB2 STAT5A STAT5B SLC4A1 GPX3 CSF2

Drugs & Therapeutics for Anemia of Prematurity

Drugs for Anemia of Prematurity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2 209810-58-2, 11096-26-7
2 Epoetin alfa Phase 2,Phase 1 113427-24-0
3 Hematinics Phase 2,Phase 1
4 Pharmaceutical Solutions Phase 1, Phase 2
5
Benzocaine Approved, Investigational Phase 1 1994-09-7, 94-09-7 2337
6 tannic acid Approved, Nutraceutical Phase 1
7 Disinfectants Phase 1
8
Iron Approved 7439-89-6 23925
9 Antioxidants
10 Micronutrients
11 Protective Agents
12 Trace Elements
13 Anti-Infective Agents
14 Hepcidins
15 Iron Supplement Nutraceutical

Interventional clinical trials:

(show all 17)

# Name Status NCT ID Phase Drugs
1 Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants Active, not recruiting NCT01393496 Phase 4
2 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
3 Darbepoetin Administration to Preterm Infants Unknown status NCT00334737 Phase 2 darbepoetin alfa;erythropoietin;sham injection
4 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
5 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
6 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
7 Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
8 Autologous Umbilical Cord Blood Transfusion for Preterm Neonates Unknown status NCT01121328 Phase 1
9 The Effect of Blood Transfusion on Blood Flow to the Intestines of Premature Infants Completed NCT00167388 Phase 1
10 Autologous Cord Blood Transfusion in Preterm Infants Completed NCT02101086
11 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
12 Erythropoietin Treatment in Extremely Low Birth Weight Infants Completed NCT00593801 epoetin beta;epoetin beta
13 Early Versus Late Enteral Iron in Infants Less Than 1301 Grams Completed NCT00458068 Oral administration of ferrous sulphate
14 Hepcidin Levels in Preterm Infants Completed NCT01539356
15 Neurodevelopment After Early Iron Supplementation Completed NCT00457990 Oral administration of ferrous sulphate
16 Combining Restrictive Guidelines and a NIRS SCORE to Decrease RBC Transfusions Recruiting NCT02535208
17 Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates Terminated NCT01735552

Search NIH Clinical Center for Anemia of Prematurity

Genetic Tests for Anemia of Prematurity

Anatomical Context for Anemia of Prematurity

MalaCards organs/tissues related to Anemia of Prematurity:

38
Brain, Neutrophil, Heart

Publications for Anemia of Prematurity

Articles related to Anemia of Prematurity:

(show top 50) (show all 98)
# Title Authors Year
1
Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. ( 28783992 )
2017
2
Exploring the use of expanded erythroid cells for autologous transfusion for anemia of prematurity. ( 23521158 )
2013
3
Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. ( 22737576 )
2012
4
Sucking improvement following blood transfusion for anemia of prematurity. ( 22664924 )
2012
5
Necrotizing enterocolitis and the role of anemia of prematurity. ( 22818548 )
2012
6
Erythropoietin in anemia of prematurity. ( 23025776 )
2012
7
Effect of short-term recombinant human erythropoietin therapy in the prevention of anemia of prematurity in very low birth weight neonates. ( 23540189 )
2012
8
Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity? ( 20303035 )
2010
9
Erythrocyte transfusions and serum prohepcidin levels in premature newborns with anemia of prematurity. ( 19816209 )
2009
10
Current controversies in the management of the anemia of prematurity. ( 19167579 )
2009
11
A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity. ( 18507748 )
2008
12
Pathophysiology of Anemia During the Neonatal Period, Including Anemia of Prematurity. ( 20463861 )
2008
13
A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity. ( 16818564 )
2006
14
Controversies in the management of the anemia of prematurity using single-donor red blood cell transfusions and/or recombinant human erythropoietin. ( 16373186 )
2006
15
Effects of transfusion in anemia of prematurity. ( 16166047 )
2005
16
Erythropoietin in anemia of prematurity. ( 12785302 )
2003
17
Does early erythropoietin therapy decrease transfusions in anemia of prematurity? ( 12061670 )
2002
18
Iron status and the treatment of the anemia of prematurity. ( 12168242 )
2002
19
Human recombinant erythropoietin in the prevention and treatment of anemia of prematurity. ( 11888358 )
2002
20
[The effect of recombinant human erythropoietin on the treatment of anemia of prematurity] ( 14647595 )
2001
21
Managing the anemia of prematurity: red blood cell transfusions versus recombinant erythropoietin. ( 11471123 )
2001
22
The role of high-dose oral iron supplementation during erythropoietin therapy for anemia of prematurity. ( 11533837 )
2001
23
Meta-analysis of controlled clinical trials studying the efficacy of rHuEPO in reducing blood transfusions in the anemia of prematurity. ( 11274599 )
2001
24
Anemia of prematurity. ( 12144218 )
2001
25
[Prophylaxis of anemia of prematurity with erythropoietin. Case control study]. ( 11083968 )
2000
26
Erythropoietin to prevent and treat the anemia of prematurity. ( 10202619 )
1999
27
Comparison between two and five doses a week of recombinant human erythropoietin for anemia of prematurity: a randomized trial. ( 10428996 )
1999
28
Financial impact of the introduction of erythropoietin in the treatment of anemia of premature infants in Israel. ( 10731302 )
1999
29
Recombinant human erythropoietin in anemia of prematurity. ( 10709119 )
1999
30
The use of erythropoietin in treatment of anemia of prematurity. ( 9601351 )
1998
31
Recombinant human erythropoietin therapy for treatment of anemia of prematurity in very low birth weight infants: a randomized, double-blind, placebo-controlled trial. ( 9659643 )
1998
32
Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity in infants with bronchopulmonary dysplasia. ( 9580761 )
1998
33
[Randomized multi-center trial of the administration of erythropoietin in anemia of prematurity]. ( 9297428 )
1997
34
Recombinant erythropoietin for the anemia of prematurity: still a promise, not a panacea. ( 9403639 )
1997
35
Recombinant human erythropoietin as a treatment for anemia of prematurity. ( 9451192 )
1997
36
Erythropoietin to treat anemia of prematurity. ( 9161667 )
1997
37
The role of erythropoietin in the anemia of prematurity. ( 9190030 )
1997
38
Effect of protein intake on erythropoiesis during erythropoietin treatment of anemia of prematurity. ( 8618185 )
1996
39
Do cardiac output and serum lactate levels indicate blood transfusion requirements in anemia of prematurity? ( 8796405 )
1996
40
Erythropoietin therapy for anemia of prematurity. ( 8772909 )
1996
41
Recombinant human erythropoietin in the treatment of anemia of prematurity. ( 8540930 )
1995
42
[Evaluation of treatment results for anemia of prematurity treated with various doses of human recombinant erythropoietin]. ( 8657506 )
1995
43
Use of epoetin (erythropoietin) in the anemia of prematurity. ( 7747503 )
1995
44
Erythropoietin--not yet a standard treatment for anemia of prematurity. ( 7770317 )
1995
45
A cost analysis comparing erythropoietin and red cell transfusions in the treatment of anemia of prematurity. ( 8604492 )
1995
46
[Effects of recombinant human erythropoietin in the treatment of anemia of prematurity]. ( 7739926 )
1995
47
Potential for treatment of anemia of prematurity with recombinant human erythropoietin. ( 7787927 )
1995
48
Follow-up of very low birth weight infants after erythropoietin treatment to prevent anemia of prematurity. ( 7636658 )
1995
49
Pathophysiology and treatment of the anemia of prematurity. ( 7743231 )
1995
50
The effect of recombinant human erythropoietin in treating the anemia of prematurity. ( 7793277 )
1995

Variations for Anemia of Prematurity

Expression for Anemia of Prematurity

Search GEO for disease gene expression data for Anemia of Prematurity.

Pathways for Anemia of Prematurity

Pathways related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 CSF2 CSF3 EPO EPOR IL3 KITLG
2
Show member pathways
13.2 CSF2 CSF3 EPOR IL3 KITLG STAT5A
3
Show member pathways
12.78 CSF3 EPO EPOR IL3 KITLG
4 12.63 EPO EPOR IL3 KITLG STAT5A STAT5B
5 12.36 IL3 KITLG STAT5A STAT5B
6
Show member pathways
12.08 CSF2 CSF3 EPO EPOR IL3 STAT5A
7
Show member pathways
12.01 EPO EPOR IL3 KITLG STAT5A STAT5B
8 11.8 CSF2 CSF3 EPO GYPA IL3 KITLG
9
Show member pathways
11.78 IL3 STAT5A STAT5B
10
Show member pathways
11.69 EPO EPOR STAT5A STAT5B
11 11.67 EPO EPOR IL3 STAT5A STAT5B
12 11.58 CSF2 STAT5A STAT5B
13 11.49 CSF2 CSF3 EPO EPOR GYPA IL3
14 11.33 EPO IL3 KITLG
15 11.11 CSF2 CSF3 IL3
16 10.98 STAT5A STAT5B
17 10.85 STAT5A STAT5B
18 10.85 CSF2 CSF3 EPO GYPA IL3 KITLG
19 10.84 CSF2 CSF3 EPOR IL3 KITLG

GO Terms for Anemia of Prematurity

Cellular components related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CSF2 CSF3 EPO GPX3 HAMP IL3
2 extracellular region GO:0005576 9.23 CSF2 CSF3 EPO EPOR GPX3 HAMP

Biological processes related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.8 CSF2 CSF3 HAMP
2 peptidyl-tyrosine phosphorylation GO:0018108 9.78 CSF2 IL3 STAT5A STAT5B
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.74 CSF3 IL3 KITLG
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 CSF2 EPO IL3
5 positive regulation of cell proliferation GO:0008284 9.63 CSF2 CSF3 EPO IL3 KITLG STAT5B
6 positive regulation of Ras protein signal transduction GO:0046579 9.62 EPO KITLG
7 cytokine-mediated signaling pathway GO:0019221 9.62 CSF3 EPOR IL3 STAT5B
8 response to vitamin A GO:0033189 9.61 EPO HAMP
9 2-oxoglutarate metabolic process GO:0006103 9.61 STAT5A STAT5B
10 embryonic hemopoiesis GO:0035162 9.6 IL3 KITLG
11 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.59 STAT5A STAT5B
12 interleukin-15-mediated signaling pathway GO:0035723 9.58 STAT5A STAT5B
13 oxaloacetate metabolic process GO:0006107 9.58 STAT5A STAT5B
14 creatine metabolic process GO:0006600 9.56 STAT5A STAT5B
15 succinate metabolic process GO:0006105 9.55 STAT5A STAT5B
16 citrate metabolic process GO:0006101 9.52 STAT5A STAT5B
17 valine metabolic process GO:0006573 9.51 STAT5A STAT5B
18 taurine metabolic process GO:0019530 9.49 STAT5A STAT5B
19 erythropoietin-mediated signaling pathway GO:0038162 9.46 EPO EPOR
20 creatinine metabolic process GO:0046449 9.43 STAT5A STAT5B
21 regulation of receptor activity GO:0010469 9.43 CSF2 CSF3 EPO HAMP IL3 KITLG
22 isoleucine metabolic process GO:0006549 9.4 STAT5A STAT5B
23 neutrophil differentiation GO:0030223 9.37 CSF2 CSF3
24 allantoin metabolic process GO:0000255 9.26 STAT5A STAT5B
25 positive regulation of DNA replication GO:0045740 8.92 CSF2 EPO IL3 KITLG

Molecular functions related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 CSF2 CSF3 IL3 KITLG
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 CSF2 IL3 KITLG
3 protein tyrosine kinase activity GO:0004713 9.26 CSF2 IL3 STAT5A STAT5B
4 cytokine activity GO:0005125 9.02 CSF2 CSF3 EPO IL3 KITLG

Sources for Anemia of Prematurity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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