MCID: ANM001
MIFTS: 42

Anemia of Prematurity

Categories: Fetal diseases, Blood diseases

Aliases & Classifications for Anemia of Prematurity

MalaCards integrated aliases for Anemia of Prematurity:

Name: Anemia of Prematurity 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:11243
ICD10 33 P61.2
ICD9CM 35 776.6
NCIt 47 C97167
SNOMED-CT 64 47100003
UMLS 69 C0158996

Summaries for Anemia of Prematurity

MalaCards based summary : Anemia of Prematurity is related to erythropoietin polycythemia and sideroblastic anemia. An important gene associated with Anemia of Prematurity is EPO (Erythropoietin), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Iron and Ferric oxide, saccharated have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lung, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 72 Anemia of prematurity refers to a form of anemia affecting preterm infants with decreased... more...

Related Diseases for Anemia of Prematurity

Diseases related to Anemia of Prematurity via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 erythropoietin polycythemia 10.7 EPO EPOR
2 sideroblastic anemia 10.7 CSF2 IL3
3 pontocerebellar hypoplasia type 2b 10.7 EPO IL3
4 atrioventricular septal defect 2 10.6 EPO EPOR
5 hypocalciuric hypercalcemia, type iii 10.6 EPO KITLG
6 disseminated intravascular coagulation 10.6 EPO EPOR
7 acute myeloblastic leukemia without maturation 10.5 CSF2 EPO
8 methemoglobinemia 10.5 EPO EPOR IL3
9 granulomatous hepatitis 10.5 CSF2 EPO IL3
10 cystic adventitial disease 10.4 CSF2 IL3 KITLG
11 postsynaptic congenital myasthenic syndromes 10.3 EPO IL3
12 lymphocytic gastritis 10.3 CSF2 IL3
13 microcystic adenoma 10.3 CSF2 IL3 KITLG
14 autoimmune disease of exocrine system 10.2 STAT5A STAT5B
15 maxillary sinus schneiderian papilloma 10.1 STAT5A STAT5B
16 enterovesical fistula 10.1 CSF2 CSF3
17 pmm2-congenital disorder of glycosylation 10.1 STAT5A STAT5B
18 primary systemic mycosis 10.1 CSF2 CSF3
19 hunter macpherson syndrome 10.0 CSF2 STAT5A
20 blood coagulation disease 9.9 CSF2 CSF3 EPO
21 duane anomaly mental retardation 9.9 CSF3 EPOR
22 neutropenia, severe congenital 3, autosomal recessive 9.9 CSF2 CSF3 IL3
23 neutropenia, severe congenital 1, autosomal dominant 9.9 CSF2 CSF3 IL3
24 lymphangiectasia, intestinal 9.9 CSF2 CSF3 IL3
25 skin atrophy 9.8 CSF2 CSF3 EPO
26 thrombocythemia 3 9.6 EPO EPOR IL3 KITLG STAT5A
27 afferent loop syndrome 9.6 EPO EPOR IL3 KITLG STAT5A
28 exertional headache 9.6 CSF3 EPO EPOR KITLG
29 dilated cardiomyopathy 9.6 CSF2 EPO EPOR GYPA IL3 KITLG
30 cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 9.6 EPO EPOR IL3 STAT5A STAT5B
31 deficiency anemia 9.5
32 bronchopulmonary dysplasia 9.5
33 iron deficiency anemia 9.5
34 ischemia 9.5
35 basilar artery insufficiency 9.5 EPO EPOR IL3 STAT5A STAT5B
36 benign mammary dysplasia 9.5 CSF2 CSF3 IL3 KITLG
37 single ventricular heart 9.5 CSF2 CSF3 IL3 KITLG
38 niemann-pick disease 9.3 CSF2 CSF3 EPO IL3 KITLG
39 lacrimal system cancer 9.3 CSF2 CSF3 EPO HAMP IL3
40 hypocalciuric hypercalcemia, type i 9.3 CSF2 CSF3 EPO IL3 KITLG
41 tendinosis 9.3 CSF3 EPO EPOR HAMP IL3
42 hemolytic anemia 9.1 CSF2 CSF3 IL3 KITLG STAT5B
43 spinocerebellar ataxia, autosomal recessive 21 9.0 CSF3 IL3 STAT5B
44 myelofibrosis with myeloid metaplasia, somatic 8.9 CSF3 EPO IL3 STAT5A STAT5B
45 malaria 8.9 CSF2 CSF3 EPO GYPA HAMP SLC4A1
46 leukemia, acute myeloid 8.6 CSF2 CSF3 EPO EPOR IL3 KITLG
47 peroxisome biogenesis disorder 7a 8.4 CSF2 CSF3 EPO IL3 KITLG STAT5A
48 cranioectodermal dysplasia 1 8.3 CSF2 CSF3 GYPA IL3 KITLG STAT5A
49 nelson syndrome 8.1 CSF2 CSF3 EPO EPOR IL3 KITLG
50 dic in newborn 4.8 CSF2 CSF3 EPO EPOR GPX3 GYPA

Graphical network of the top 20 diseases related to Anemia of Prematurity:



Diseases related to Anemia of Prematurity

Symptoms & Phenotypes for Anemia of Prematurity

MGI Mouse Phenotypes related to Anemia of Prematurity:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 CSF2 EPO EPOR GPX3 HIF1AN KITLG
2 hematopoietic system MP:0005397 10.11 CSF2 CSF3 EPO EPOR GPX3 KITLG
3 cellular MP:0005384 10.1 STAT5B CSF2 EPO EPOR HIF1AN KITLG
4 cardiovascular system MP:0005385 10.09 CSF2 EPO EPOR GPX3 HIF1AN KITLG
5 immune system MP:0005387 9.96 CSF2 CSF3 EPO EPOR KITLG PTGDR
6 integument MP:0010771 9.81 CSF2 CSF3 EPO KITLG PTGDR SLC4A1
7 liver/biliary system MP:0005370 9.56 EPO EPOR HIF1AN KITLG SCO2 STAB2
8 mortality/aging MP:0010768 9.36 CSF2 EPO EPOR GPX3 KITLG PTGDR

Drugs & Therapeutics for Anemia of Prematurity

Drugs for Anemia of Prematurity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
2 Ferric oxide, saccharated Phase 4
3 Hematinics Phase 4,Phase 2,Phase 3,Phase 1
4 Micronutrients Phase 4,Phase 3,Phase 2
5 Trace Elements Phase 4,Phase 3,Phase 2
6 Epoetin alfa Phase 4,Phase 2,Phase 3,Phase 1 113427-24-0
7 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
8 Iron Supplement Nutraceutical Phase 4,Phase 2,Phase 3
9
Pyrimethamine Approved, Vet_approved Phase 3 58-14-0 4993
10
Sulfadoxine Approved Phase 3 2447-57-6 17134
11
Copper Approved Phase 3 7440-50-8 27099
12
Hydroxocobalamin Approved Phase 3 13422-51-0 11953898 5460373 44475014
13
Selenium Approved, Vet_approved Phase 3 7782-49-2
14
Zinc Approved Phase 3 7440-66-6 32051 23994
15
Sulfamethoxazole Approved Phase 3 723-46-6 5329
16
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
18
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
19
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
20
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
21
Nicotinamide Approved, Nutraceutical Phase 3 98-92-0 936
22 Orange Approved, Nutraceutical Phase 3
23
Pyridoxal Approved, Nutraceutical Phase 3 66-72-8 1050
24
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 3 65-23-6 1054
25
Riboflavin Approved, Nutraceutical, Vet_approved Phase 3 83-88-5 493570
26
Thiamine Approved, Nutraceutical, Vet_approved Phase 3 59-43-8 1130
27 Tocopherol Approved, Nutraceutical Phase 3
28
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
29
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
30
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
31
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
32
Iodine Investigational Phase 3 7553-56-2 807
33 Dextrans Phase 2, Phase 3
34 Iron-Dextran Complex Phase 2, Phase 3
35 Antioxidants Phase 3,Phase 1,Phase 2
36 Protective Agents Phase 3,Phase 1,Phase 2
37 Vitamin B Complex Phase 3,Phase 2
38 Vitamins Phase 3,Phase 2
39 Anti-Infective Agents Phase 3
40 Antimalarials Phase 3
41 Antiparasitic Agents Phase 3
42 Antiprotozoal Agents Phase 3
43 Fanasil, pyrimethamine drug combination Phase 3
44 Folic Acid Antagonists Phase 3
45 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
46 Bone Density Conservation Agents Phase 3
47 cadexomer iodine Phase 3
48 Dermatologic Agents Phase 3
49 Nicotinic Acids Phase 3
50 Photosensitizing Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 57)

id Name Status NCT ID Phase Drugs
1 Effects of Early Short-term Intravenous Iron Supplements Combinded EPO in Preterm Infants Unknown status NCT02060851 Phase 4 Iron sucrose;EPO
2 Effect of Erythropoietin on Preterm Brain Injury Completed NCT02036073 Phase 4 recombinant human erythropoietin
3 Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants Active, not recruiting NCT01393496 Phase 4
4 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
5 Early Detection of Anaemia During the Maternity Completed NCT00827463 Phase 3
6 Randomized Trial of Iron Supplementation to Prevent Anemia in Very-low-birth-weight Infants Completed NCT01224236 Phase 2, Phase 3 Iron Supplement;control
7 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
8 The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants Completed NCT01203514 Phase 2, Phase 3 Erythropoietin
9 Impact of Pre-pregnancy Micronutrient Supplementation on Maternal and Child Outcomes Active, not recruiting NCT01665378 Phase 3
10 Transfusion of Prematures Trial Active, not recruiting NCT01702805 Phase 3
11 Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy Terminated NCT00711906 Phase 3 Cotrimoxazole;Sulfadoxine-pyrimethamine
12 Darbepoetin Administration to Preterm Infants Unknown status NCT00334737 Phase 2 darbepoetin alfa;erythropoietin;sham injection
13 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
14 Milking the Umbilical Cord Versus Immediate Clamping in Pre-term Infants < 33 Weeks Unknown status NCT01819532 Phase 2
15 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
16 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 2 Ferrous bis-glycinate;Ferrous glycine sulphate
17 Impact of One Versus Two Amino Acid Chelated Iron Capsules on Prevention of Iron Deficiency Anemia in Non-anemic Women With Twin Gestations Completed NCT02858505 Phase 2 27 mg elemental iron;54 mg elemental iron
18 Randomized Study of Weekly Erythropoietin Dosing in Preterm Infants Completed NCT01235923 Phase 2 three times weekly Epo;weekly Epo
19 Red Blood Cell (RBC) Survival Following Transfusion in Infants Completed NCT00731588 Phase 2
20 A Study of Mircera in Anemic Patients With Non-Small Cell Lung Cancer Receiving First Line Chemotherapy. Completed NCT00327535 Phase 2 Darbepoetin alfa;methoxy polyethylene glycol-epoetin beta [Mircera];methoxy polyethylene glycol-epoetin beta [Mircera];methoxy polyethylene glycol-epoetin beta [Mircera]
21 Optimized Erythropoietin (EPO) Treatment Recruiting NCT02075970 Phase 2 Epoetin Alpha;Biotinylated Red Blood Cells
22 Prevention of Transfusion Related Acute Gut Injury (TRAGI) in Extremely Low Gestational Age Neonates (ELGANs) Using iNO Not yet recruiting NCT02851472 Phase 1, Phase 2 Inhaled Nitric Oxide;Placebo
23 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
24 Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
25 Autologous Umbilical Cord Blood Transfusion for Preterm Neonates Unknown status NCT01121328 Phase 1
26 The Effect of Blood Transfusion on Blood Flow to the Intestines of Premature Infants Completed NCT00167388 Phase 1
27 Effect of Iron-fortified TPN on Preterm Infants Anemia Unknown status NCT01813682
28 Delayed Umbilical Cord Clamping in Infants Less Than 32 Weeks Unknown status NCT00562536
29 Cord Milking and Activity Of The Immune System In Preterm Infants Unknown status NCT02043249
30 Trial Comparing Iron Supplementation Versus Routine Iron Intake in Very Low Birth Weight (VLBW) Infants Unknown status NCT01125163
31 Autologous Cord Blood Transfusion in Preterm Infants Completed NCT02101086
32 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
33 Erythropoietin Treatment in Extremely Low Birth Weight Infants Completed NCT00593801 epoetin beta;epoetin beta
34 Early Versus Late Enteral Iron in Infants Less Than 1301 Grams Completed NCT00458068 Oral administration of ferrous sulphate
35 Hepcidin Levels in Preterm Infants Completed NCT01539356
36 Neurodevelopment After Early Iron Supplementation Completed NCT00457990 Oral administration of ferrous sulphate
37 Effect of Maternal Hemoglobin on Neurobehavioural Development of Late Preterm Neonates : A Cohort Study Completed NCT02840292
38 Dietary Diversity is Associated With Maternal Anemia and Key Prenatal Outcomes in Ethiopia Completed NCT02620943
39 Transfusions and Nitric Oxide Level in Preterm Infants Completed NCT00787124
40 Liberal Versus Restrictive Transfusion Guidelines for Preterm Infants Completed NCT00369005
41 Latent Iron Deficiency at Birth Influences Auditory Neural Maturation in Late Preterm and Term Infants Completed NCT02503397
42 Impact of IPT With Sulfadoxin Pyrimetamin on Pregnant Women and Their Babies Outcomes in Peri-urban Areas of Bobo-Dioulasso(Burkina Faso) Completed NCT01255605
43 Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT Completed NCT02473796
44 Combining Restrictive Guidelines and a NIRS SCORE to Decrease RBC Transfusions Recruiting NCT02535208
45 Iron-fortified Parenteral Nutrition in the Prevention and Treatment of Anemia in Premature Infants Recruiting NCT02743572
46 The Study on Umbilical Cord Milking to Prevent and Decrease the Severity of Anemia in Preterms Recruiting NCT03023917
47 RBC Irradiation, Anemia and Gut Injury Recruiting NCT02741648
48 Umbilical Cord Blood Use For Admission Blood Tests of Very Low Birth Weight Preterm Neonates: A Multi-center Randomized Clinical Trial Recruiting NCT02103296
49 Serum Ferritin Concentration and Fetal MCA Doppler as Predictors for Preterm Delivery Recruiting NCT02420743
50 Use of Cast Iron Pots to Improve Maternal Anemia Recruiting NCT02341300

Search NIH Clinical Center for Anemia of Prematurity

Genetic Tests for Anemia of Prematurity

Anatomical Context for Anemia of Prematurity

MalaCards organs/tissues related to Anemia of Prematurity:

39
Brain, Testes, Lung, Bone, Neutrophil, Heart

Publications for Anemia of Prematurity

Articles related to Anemia of Prematurity:

(show top 50) (show all 98)
id Title Authors Year
1
Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. ( 28783992 )
2017
2
Exploring the use of expanded erythroid cells for autologous transfusion for anemia of prematurity. ( 23521158 )
2013
3
Effect of short-term recombinant human erythropoietin therapy in the prevention of anemia of prematurity in very low birth weight neonates. ( 23540189 )
2012
4
Erythropoietin in anemia of prematurity. ( 23025776 )
2012
5
Sucking improvement following blood transfusion for anemia of prematurity. ( 22664924 )
2012
6
Necrotizing enterocolitis and the role of anemia of prematurity. ( 22818548 )
2012
7
Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. ( 22737576 )
2012
8
Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity? ( 20303035 )
2010
9
Erythrocyte transfusions and serum prohepcidin levels in premature newborns with anemia of prematurity. ( 19816209 )
2009
10
Current controversies in the management of the anemia of prematurity. ( 19167579 )
2009
11
Pathophysiology of Anemia During the Neonatal Period, Including Anemia of Prematurity. ( 20463861 )
2008
12
A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity. ( 18507748 )
2008
13
A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity. ( 16818564 )
2006
14
Controversies in the management of the anemia of prematurity using single-donor red blood cell transfusions and/or recombinant human erythropoietin. ( 16373186 )
2006
15
Effects of transfusion in anemia of prematurity. ( 16166047 )
2005
16
Erythropoietin in anemia of prematurity. ( 12785302 )
2003
17
Iron status and the treatment of the anemia of prematurity. ( 12168242 )
2002
18
Does early erythropoietin therapy decrease transfusions in anemia of prematurity? ( 12061670 )
2002
19
Human recombinant erythropoietin in the prevention and treatment of anemia of prematurity. ( 11888358 )
2002
20
Meta-analysis of controlled clinical trials studying the efficacy of rHuEPO in reducing blood transfusions in the anemia of prematurity. ( 11274599 )
2001
21
Anemia of prematurity. ( 12144218 )
2001
22
[The effect of recombinant human erythropoietin on the treatment of anemia of prematurity] ( 14647595 )
2001
23
The role of high-dose oral iron supplementation during erythropoietin therapy for anemia of prematurity. ( 11533837 )
2001
24
Managing the anemia of prematurity: red blood cell transfusions versus recombinant erythropoietin. ( 11471123 )
2001
25
[Prophylaxis of anemia of prematurity with erythropoietin. Case control study]. ( 11083968 )
2000
26
Comparison between two and five doses a week of recombinant human erythropoietin for anemia of prematurity: a randomized trial. ( 10428996 )
1999
27
Recombinant human erythropoietin in anemia of prematurity. ( 10709119 )
1999
28
Erythropoietin to prevent and treat the anemia of prematurity. ( 10202619 )
1999
29
Financial impact of the introduction of erythropoietin in the treatment of anemia of premature infants in Israel. ( 10731302 )
1999
30
Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity in infants with bronchopulmonary dysplasia. ( 9580761 )
1998
31
The use of erythropoietin in treatment of anemia of prematurity. ( 9601351 )
1998
32
Recombinant human erythropoietin therapy for treatment of anemia of prematurity in very low birth weight infants: a randomized, double-blind, placebo-controlled trial. ( 9659643 )
1998
33
[Randomized multi-center trial of the administration of erythropoietin in anemia of prematurity]. ( 9297428 )
1997
34
Recombinant erythropoietin for the anemia of prematurity: still a promise, not a panacea. ( 9403639 )
1997
35
Erythropoietin to treat anemia of prematurity. ( 9161667 )
1997
36
Recombinant human erythropoietin as a treatment for anemia of prematurity. ( 9451192 )
1997
37
The role of erythropoietin in the anemia of prematurity. ( 9190030 )
1997
38
Erythropoietin therapy for anemia of prematurity. ( 8772909 )
1996
39
Effect of protein intake on erythropoiesis during erythropoietin treatment of anemia of prematurity. ( 8618185 )
1996
40
Do cardiac output and serum lactate levels indicate blood transfusion requirements in anemia of prematurity? ( 8796405 )
1996
41
Erythropoietin--not yet a standard treatment for anemia of prematurity. ( 7770317 )
1995
42
Pathophysiology and treatment of the anemia of prematurity. ( 7743231 )
1995
43
Use of epoetin (erythropoietin) in the anemia of prematurity. ( 7747503 )
1995
44
[Evaluation of treatment results for anemia of prematurity treated with various doses of human recombinant erythropoietin]. ( 8657506 )
1995
45
Potential for treatment of anemia of prematurity with recombinant human erythropoietin. ( 7787927 )
1995
46
The effect of recombinant human erythropoietin in treating the anemia of prematurity. ( 7793277 )
1995
47
[Effects of recombinant human erythropoietin in the treatment of anemia of prematurity]. ( 7739926 )
1995
48
A cost analysis comparing erythropoietin and red cell transfusions in the treatment of anemia of prematurity. ( 8604492 )
1995
49
Recombinant human erythropoietin in the treatment of anemia of prematurity. ( 8540930 )
1995
50
Follow-up of very low birth weight infants after erythropoietin treatment to prevent anemia of prematurity. ( 7636658 )
1995

Variations for Anemia of Prematurity

Expression for Anemia of Prematurity

Search GEO for disease gene expression data for Anemia of Prematurity.

Pathways for Anemia of Prematurity

Pathways related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CSF2 CSF3 EPO EPOR IL3 KITLG
2
Show member pathways
13.18 CSF2 CSF3 EPOR IL3 KITLG STAT5A
3 12.47 CSF3 EPO EPOR IL3 KITLG
4 12.32 IL3 KITLG STAT5A STAT5B
5
Show member pathways
12.01 EPO EPOR IL3 KITLG STAT5A STAT5B
6
Show member pathways
11.94 CSF2 CSF3 EPO EPOR IL3 STAT5A
7 11.8 CSF2 CSF3 EPO GYPA IL3 KITLG
8
Show member pathways
11.76 IL3 STAT5A STAT5B
9 11.71 EPO EPOR IL3 STAT5A STAT5B
10
Show member pathways
11.69 EPO EPOR STAT5A STAT5B
11 11.57 CSF2 STAT5A STAT5B
12 11.49 CSF2 CSF3 EPO EPOR GYPA IL3
13 11.31 EPO IL3 KITLG
14 11.09 CSF2 CSF3 IL3
15
Show member pathways
11.03 STAT5A STAT5B
16 10.85 CSF2 CSF3 EPO GYPA IL3 KITLG
17 10.83 STAT5A STAT5B

GO Terms for Anemia of Prematurity

Cellular components related to Anemia of Prematurity according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CSF2 CSF3 EPO GPX3 HAMP IL3
2 extracellular region GO:0005576 9.23 CSF2 CSF3 EPO EPOR GPX3 HAMP

Biological processes related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.79 CSF2 CSF3 HAMP
2 peptidyl-tyrosine phosphorylation GO:0018108 9.76 CSF2 IL3 STAT5A STAT5B
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.74 CSF3 IL3 KITLG
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 CSF2 EPO IL3
5 cytokine-mediated signaling pathway GO:0019221 9.62 CSF3 EPOR IL3 STAT5B
6 response to vitamin A GO:0033189 9.61 EPO HAMP
7 positive regulation of Ras protein signal transduction GO:0046579 9.6 EPO KITLG
8 2-oxoglutarate metabolic process GO:0006103 9.59 STAT5A STAT5B
9 embryonic hemopoiesis GO:0035162 9.58 IL3 KITLG
10 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.58 STAT5A STAT5B
11 oxaloacetate metabolic process GO:0006107 9.56 STAT5A STAT5B
12 creatine metabolic process GO:0006600 9.55 STAT5A STAT5B
13 succinate metabolic process GO:0006105 9.54 STAT5A STAT5B
14 citrate metabolic process GO:0006101 9.51 STAT5A STAT5B
15 taurine metabolic process GO:0019530 9.49 STAT5A STAT5B
16 valine metabolic process GO:0006573 9.48 STAT5A STAT5B
17 creatinine metabolic process GO:0046449 9.43 STAT5A STAT5B
18 positive regulation of cell proliferation GO:0008284 9.43 CSF2 CSF3 EPO IL3 KITLG STAT5B
19 isoleucine metabolic process GO:0006549 9.4 STAT5A STAT5B
20 erythropoietin-mediated signaling pathway GO:0038162 9.26 EPO EPOR
21 allantoin metabolic process GO:0000255 9.16 STAT5A STAT5B
22 neutrophil differentiation GO:0030223 9.07 CSF2
23 positive regulation of DNA replication GO:0045740 8.92 CSF2 EPO IL3 KITLG

Molecular functions related to Anemia of Prematurity according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CSF2 CSF3 IL3 KITLG
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 CSF2 IL3 KITLG
3 protein tyrosine kinase activity GO:0004713 9.26 CSF2 IL3 STAT5A STAT5B
4 growth factor activity GO:0008083 8.92 CSF2 CSF3 IL3 KITLG

Sources for Anemia of Prematurity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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