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MCID: ANN002
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Anencephaly malady |
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Sources: 17Genetics Home Reference, 30NIH Rare Diseases, 31NINDS, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
NINDS: Anencephaly is a defect in the closure of the neural tube during fetal development. The neural tube is a narrow channel that
folds and closes between the 3rd and 4th weeks of pregnancy to form the brain and spinal cord of the embryo. Anencephaly occurs
when the "cephalic" or head end of the neural tube fails to close, resulting in the absence of a major portion of the brain,
skull, and scalp. Infants with this disorder are born without a forebrain (the front part of the brain) and a cerebrum (the
thinking and coordinating part of the brain). The remaining brain tissue is often exposed--not covered by bone or skin. A
baby born with anencephaly is usually blind, deaf, unconscious, and unable to feel pain. Although some individuals with anencephaly
may be born with a rudimentary brain stem, the lack of a functioning cerebrum permanently rules out the possibility of ever
gaining consciousness. Reflex actions such as breathing and responses to sound or touch may occur.31
MalaCards: Anencephaly, also known as aprosencephaly, is related to coronary artery anomaly and congenital heart defect. An important gene associated with Anencephaly is AFP (alpha-fetoprotein), and among its related pathways are One carbon pool by folate and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds fasciculin and Demecarium have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and skin, and related mouse phenotypes are growth/size and reproductive system. Genetics Home Reference: Anencephaly is a condition that prevents the normal development of the brain and the bones of the skull. This condition results when a structure called the neural tube fails to close during the first few weeks of embryonic development. The neural tube is a layer of cells that ultimately develops into the brain and spinal cord. Because anencephaly is caused by abnormalities of the neural tube, it is classified as a neural tube defect (NTD).17 NIH Rare Diseases: Anencephaly is a defect in the closure of the neural tube during fetal development. The neural tube is a narrow channel that folds and closes between the 3rd and 4th weeks of pregnancy to form the brain and spinal cord of the embryo. Anencephaly occurs when the 'cephalic' or head end of the neural tube fails to close, resulting in the absence of a major portion of the brain, skull, and scalp. Infants with this disorder are born without a forebrain (the front part of the brain) and a cerebrum (the thinking and coordinating part of the brain). The remaining brain tissue is often exposed (not covered by bone or skin). A baby born with anencephaly is usually blind, deaf, unconscious, and unable to feel pain. Most cases are stillborn, although some infants have been reported to survive for a few hours or even a few days. Reflex actions such as breathing and responses to sound or touch may occur.30 Wikipedia: Anencephaly is a cephalic disorder that results from a neural tube defect that occurs when the rostral...44 more... |
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Sources: 30NIH Rare Diseases, 17Genetics Home Reference, 31NINDS, 32Novoseek , 43UMLS See all sources |
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for anencephaly Drug clinical trials:Search ClinicalTrials for anencephaly Search NIH Clinical Center for anencephaly Search CenterWatch for anencephaly |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to anencephaly:22Brain, Spinal cord, Skin, Fetal brain
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to anencephaly:25
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Sources: 35PubMed See all sources |
Articles related to anencephaly:
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Sources: 1BioGPS See all sources |
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Sources: 20KEGG, 34PharmGKB See all sources |
Pathways related to anencephaly according to GeneDecks:
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Sources: 32Novoseek , 9DrugBank, 42Tocris Bioscience, 18HMDB, 34PharmGKB See all sources |
Compounds related to anencephaly according to GeneDecks:(show top 50) (show all 130)
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Sources: 12Gene Ontology See all sources |
Biological processes related to anencephaly according to GeneDecks:
Molecular functions related to anencephaly according to GeneDecks:
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