MCID: ANR009
MIFTS: 43

Aneurysmal Bone Cysts malady

Bone category

Summaries for Aneurysmal Bone Cysts

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

MalaCards: Aneurysmal Bone Cysts, also known as bone cysts, aneurysmal, is related to cherubism and chondroblastoma. An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal bone cysts), and among its related pathways are LPA receptor mediated events and G12-G13 in Cellular Signaling. The compounds 1,3,7,12-Tetrahydroxycholan-24-oic acid and sumatriptan have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and b cells, and related mouse phenotypes are normal and behavior/neurological.

Aliases & Classifications for Aneurysmal Bone Cysts

Sources:
43NIH Rare Diseases, 47OMIM, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Aliases & Descriptions:

aneurysmal bone cysts 43 47 31
bone cysts, aneurysmal 61
bone cysts aneurysmal 45


External Ids:

ICD1025 M85.5

Related Diseases for Aneurysmal Bone Cysts

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to aneurysmal bone cysts

Clinical Features for Aneurysmal Bone Cysts

Drugs & Therapeutics for Aneurysmal Bone Cysts

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aneurysmal Bone Cysts

Drug clinical trials:

Search ClinicalTrials for Aneurysmal Bone Cysts

Search NIH Clinical Center for Aneurysmal Bone Cysts

Search CenterWatch for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Anatomical Context for Aneurysmal Bone Cysts

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

33
Bone marrow, T cells, B cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Aneurysmal Bone Cysts or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Aneurysmal Bone Cysts:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.8CDK5, MAPT, NFKB1, CALCA, GSK3B, COL1A1
2MP:00053867.7COL1A1, CALCA, OMD, NFKB1, MAPT, CDK5
3MP:00107717.7MAPT, CALCA, CDH11, CDK5, COL1A1, NFKB1

Publications for Aneurysmal Bone Cysts

Sources:
51PubMed
See all sources

Articles related to Aneurysmal Bone Cysts:

(show top 50)    (show all 171)
idTitleAuthorsYear
1
Sclerotherapy with polidocanol for treatment of aneurysmal bone cysts. (24171682)
2013
2
Aneurysmal bone cysts. (24049942)
2013
3
A comparison of cyst wall curettage and en bloc excision in the treatment of aneurysmal bone cysts. (23701661)
2013
4
Letter regarding "Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts". (23963484)
2013
5
Reviewer's comment concerning "aneurysmal bone cysts of the spine" (doi:10.1007/s00586-012-2510-x by M. Zileli et al.). (23090092)
2013
6
Aneurysmal bone cysts clinically mimicking a parotid gland mass. (23172457)
2012
7
Surgical treatment for primary spinal aneurysmal bone cysts: experience from Children's Hospital Boston. (22380960)
2012
8
Curettage of aneurysmal bone cysts of the feet. (20132749)
2010
9
Aneurysmal bone cysts of the jaws. (19233862)
2009
10
Malignant transformation of aneurysmal bone cysts: a case report. (19187628)
2009
11
Long-term follow-up of Ethibloc injection in aneurysmal bone cysts. (19657285)
2009
12
Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts. (19885603)
2009
13
Injectable form of calcium sulphate as treatment of aneurysmal bone cysts. (18380735)
2008
14
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
15
Direct ethibloc injection of aneurysmal bone cysts. (16118180)
2005
16
Aneurysmal bone cysts of the pelvis in children: a multicenter study and literature review. (15958897)
2005
17
Aneurysmal bone cysts in children: complications of fibrosing agent injection. (15215542)
2004
18
Metachronous and multiple aneurysmal bone cysts: a rare variant of primary aneurysmal bone cysts. (15024646)
2004
19
Trauma-induced aneurysmal bone cysts in two psittacine species (Cacatua alba and Nymphicus hollandicus). (15305514)
2004
20
Surgical treatment and recurrence rate of aneurysmal bone cysts in children. (15123949)
2004
21
Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma. (12760943)
2003
22
Metachronous aneurysmal bone cysts with involvement of the humerus and the thoracic vertebrae. (12879296)
2003
23
Fractures through bone cysts: unicameral bone cysts, aneurysmal bone cysts, fibrous cortical defects, and nonossifying fibromas. (12064135)
2002
24
Treatment of aneurysmal bone cysts with saucerization and bone marrow injection in children. (10413010)
1999
25
Juxtaphyseal aneurysmal bone cysts. (10416410)
1999
26
Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. (10502326)
1999
27
Aneurysmal bone cysts: percutaneous embolization with an alcoholic solution of zein--series of 18 cases. (9680561)
1998
28
Aneurysmal bone cysts of the maxilla: a clinicopathologic review. (9371109)
1997
29
Multiple aneurysmal bone cysts in a foal. (9285139)
1997
30
Embolization in the treatment of aneurysmal bone cysts. (9364379)
1997
31
Intracortical and subperiosteal aneurysmal bone cysts: a report of three cases. (8837277)
1996
32
Aneurysmal bone cysts of the jaws: CT and MR findings. (1729313)
1992
33
Aneurysmal bone cysts of the dorsal spine. (2619528)
1989
34
Immunocytochemical markers (endothelial and histiocytic) and ultrastructure of primary aneurysmal bone cysts. (3080364)
1986
35
Aneurysmal bone cysts of the spine. (4018962)
1985
36
Aneurysmal bone cysts in the cranial vault and base of skull. (3966216)
1985
37
Aneurysmal bone cysts of the spine. Report of 17 cases. (4056871)
1985
38
Fluid levels in aneurysmal bone cysts: a CT feature. (6609547)
1984
39
The radiological features of "solid" aneurysmal bone cysts. (6509284)
1984
40
Selective arterial embolisation in aneurysmal bone cysts. (7152745)
1982
41
Aneurysmal bone cysts occurring in the metacarpals: a report of three cases. (722033)
1978
42
Cryosurgical treatment of aneurysmal bone cysts. (628222)
1978
43
Megavoltage therapy in patients with aneurysmal bone cysts. (814583)
1976
44
Fibrinolytic activity in aneurysmal bone cysts. (1202938)
1975
45
Two cases of aneurysmal bone cysts of the jaws. (4634128)
1972
46
Aneurysmal bone cysts. Review of twelve cases. (5238600)
1968
47
Giant-cell tumours and aneurysmal bone cysts of the spine. With special reference to the problems related to the removal of a vertebral body. (5846771)
1965
48
ANEURYSMAL BONE CYSTS. A REPORT OF SIX CASES, INCLUDING A FATAL CASE ASSOCIATED WITH A NON-OSSIFYING FIBROMA. (14346534)
1965
49
Aneurysmal bone cysts of the mandible. (13578352)
1958
50
Aneurysmal bone cysts. (13224839)
1955

Genetic Variations for Aneurysmal Bone Cysts

Expression for genes affiliated with Aneurysmal Bone Cysts

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for genes affiliated with Aneurysmal Bone Cysts

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 30KEGG
See all sources

Compounds for genes affiliated with Aneurysmal Bone Cysts

Sources:
24HMDB, 45Novoseek, 29IUPHAR, 60Tocris Bioscience, 50PharmGKB, 11DrugBank
See all sources

Compounds related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
11,3,7,12-Tetrahydroxycholan-24-oic acid2410.0SLCO1A2, SLCO4A1
2sumatriptan45 29 60 50 11 2415.0CALCA, SLCO1A2
31,3,12-Trihydroxycholan-24-oic acid249.9SLCO4A1, SLCO1A2
4(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid249.9SLCO4A1, SLCO1A2
5Aminohippurate119.8SLCO1A2, SLCO3A1
6Levothyroxine119.8SLCO4A1, SLCO1A2
7oatp459.8SLCO4A1, SLCO1A2
8Liotrix119.7SLCO4A1, SLCO1A2
9alsterpaullone45 1110.7CDK5, GSK3B
10Indirubin-3'-Monoxime119.6CDK5, GSK3B
11Penicillin G119.6SLCO4A1, SLCO3A1
12Liothyronine11 2410.6SLCO1A2, SLCO4A1
13butyrolactone i459.5CDK5, MAPT
14[3h]estrone-3-sulphate299.5SLCO4A1, SLCO3A1, SLCO1A2
15Dinoprostone119.5SLCO1A2, SLCO3A1, SLCO4A1
16conjugated estrogens50 1110.5SLCO4A1, SLCO3A1, SLCO1A2
17Taurocholic Acid11 2410.5SLCO4A1, SLCO3A1, SLCO1A2
18lithocholic acid45 29 2411.4SLCO1A2, SLCO4A1
191,25 dihydroxy vitamin d3459.3COL1A1, CDK5, CALCA
20lithium45 50 11 2412.3GSK3B, CDK5, MAPT

GO Terms for genes affiliated with Aneurysmal Bone Cysts

Sources:
16Gene Ontology
See all sources

Cellular components related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:0304268.7MAPT, CDK5, GSK3B
2plasma membraneGO:0058866.7USP6, MAPT, CDH11, CDK5, SLCO4A1, SLCO3A1

Biological processes related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon extensionGO:0486759.3CDK5, MAPT
2sodium-independent organic anion transportGO:0432528.9SLCO1A2, SLCO3A1, SLCO4A1

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.2GSK3B, GBP1, CALCA, COL1A1
2tau-protein kinase activityGO:0503219.1GSK3B, CDK5

Products for genes affiliated with Aneurysmal Bone Cysts

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aneurysmal Bone Cysts

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet