MCID: ANR009
MIFTS: 36

Aneurysmal Bone Cysts malady

Bone diseases category

Summaries for Aneurysmal Bone Cysts

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63Wikipedia, 32MalaCards
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Wikipedia:63 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

MalaCards: Aneurysmal Bone Cysts, also known as bone cysts, aneurysmal, is related to osteosarcoma and cherubism. An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal bone cysts), and among its related pathways are LPA receptor mediated events and G12-G13 in Cellular Signaling. The compounds 1,3,7,12-Tetrahydroxycholan-24-oic acid and sumatriptan have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and bone marrow, and related mouse phenotypes are normal and behavior/neurological.

Aliases & Classifications for Aneurysmal Bone Cysts

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42NIH Rare Diseases, 46OMIM, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

aneurysmal bone cysts 42 46 30
bone cysts, aneurysmal 60
bone cysts aneurysmal 44


External Ids:

ICD1025 M85.5

Related Diseases for Aneurysmal Bone Cysts

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to aneurysmal bone cysts

Clinical Features for Aneurysmal Bone Cysts

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Drugs & Therapeutics for Aneurysmal Bone Cysts

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Aneurysmal Bone Cysts

Drug clinical trials:

Search ClinicalTrials for Aneurysmal Bone Cysts

Search NIH Clinical Center for Aneurysmal Bone Cysts

Search CenterWatch for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

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Anatomical Context for Aneurysmal Bone Cysts

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Aneurysmal Bone Cysts:

32
Bone, Endothelial, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Aneurysmal Bone Cysts or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Aneurysmal Bone Cysts:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.8COL1A1, CALCA, NFKB1, MAPT, CDK5, GSK3B
2MP:00053867.7CALCA, OMD, NFKB1, MAPT, CDK5, GSK3B
3MP:00107717.7CDK5, CDH11, MAPT, NFKB1, CALCA, COL1A1

Publications for Aneurysmal Bone Cysts

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Genetic Variations for Aneurysmal Bone Cysts

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Expression for genes affiliated with Aneurysmal Bone Cysts

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for genes affiliated with Aneurysmal Bone Cysts

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG
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Compounds for genes affiliated with Aneurysmal Bone Cysts

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Sources:
24HMDB, 44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank
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Compounds related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
11,3,7,12-Tetrahydroxycholan-24-oic acid2410.0SLCO4A1, SLCO1A2
2sumatriptan44 28 59 49 11 2415.0SLCO1A2, CALCA
31,3,12-Trihydroxycholan-24-oic acid249.9SLCO4A1, SLCO1A2
4(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid249.9SLCO4A1, SLCO1A2
5Aminohippurate119.8SLCO1A2, SLCO3A1
6Levothyroxine119.8SLCO4A1, SLCO1A2
7oatp449.8SLCO4A1, SLCO1A2
8Liotrix119.7SLCO1A2, SLCO4A1
9alsterpaullone44 1110.7GSK3B, CDK5
10Indirubin-3'-Monoxime119.6GSK3B, CDK5
11Penicillin G119.6SLCO3A1, SLCO4A1
12Liothyronine11 2410.6SLCO4A1, SLCO1A2
13butyrolactone i449.5MAPT, CDK5
14[3h]estrone-3-sulphate289.5SLCO1A2, SLCO3A1, SLCO4A1
15Dinoprostone119.5SLCO4A1, SLCO3A1, SLCO1A2
16conjugated estrogens49 1110.5SLCO1A2, SLCO3A1, SLCO4A1
17Taurocholic Acid11 2410.5SLCO4A1, SLCO3A1, SLCO1A2
18lithocholic acid44 28 2411.4SLCO1A2, SLCO4A1
191,25 dihydroxy vitamin d3449.3COL1A1, CALCA, CDK5
20lithium44 49 11 2412.3MAPT, CDK5, GSK3B

GO Terms for genes affiliated with Aneurysmal Bone Cysts

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16Gene Ontology
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Cellular components related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:0304268.7GSK3B, CDK5, MAPT
2plasma membraneGO:0058866.7MAPT, CDH11, CDK5, SLCO4A1, SLCO3A1, SLCO1A2

Biological processes related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon extensionGO:0486759.3CDK5, MAPT
2sodium-independent organic anion transportGO:0432528.9SLCO1A2, SLCO3A1, SLCO4A1

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.2GSK3B, GBP1, CALCA, COL1A1
2tau-protein kinase activityGO:0503219.1GSK3B, CDK5

Products for genes affiliated with Aneurysmal Bone Cysts

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aneurysmal Bone Cysts

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet