MCID: ANR009
MIFTS: 51

Aneurysmal Bone Cysts malady

Rare diseases, Bone diseases categories

Summaries for Aneurysmal Bone Cysts

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66Wikipedia, 34MalaCards
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Wikipedia:66 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

MalaCards: Aneurysmal Bone Cysts, also known as bone cysts, aneurysmal, is related to cherubism and aneurysm. An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal bone cysts), and among its related pathways are Regulation of Microtubule Cytoskeleton and LPA receptor mediated events. The compounds Chenodeoxycholic acid disulfate and 7a-Hydroxy-5b-cholanic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and bone marrow, and related mouse phenotypes are normal and behavior/neurological.

Aliases & Classifications for Aneurysmal Bone Cysts

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44NIH Rare Diseases, 48OMIM, 46Novoseek, 32LifeMap Discoveryā„¢, 63UMLS, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Aliases & Descriptions:

aneurysmal bone cysts 44 48 32
bone cysts, aneurysmal 63
bone cysts aneurysmal 46


External Ids:

ICD1026 M85.5

Related Diseases for Aneurysmal Bone Cysts

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to aneurysmal bone cysts

Symptoms for Aneurysmal Bone Cysts

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Drugs & Therapeutics for Aneurysmal Bone Cysts

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Aneurysmal Bone Cysts

Drug clinical trials:

Search ClinicalTrials for Aneurysmal Bone Cysts

Search NIH Clinical Center for Aneurysmal Bone Cysts

Search CenterWatch for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

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Anatomical Context for Aneurysmal Bone Cysts

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32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Aneurysmal Bone Cysts:

34
Bone, Endothelial, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Aneurysmal Bone Cysts or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Aneurysmal Bone Cysts:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.0COL1A1, MAPT, CALCA, GSK3B, NFKB1, CDK5
2MP:00053867.8OMD, COL1A1, MAPT, CALCA, GSK3B, NFKB1
3MP:00107717.8CDK5, CDH11, NFKB1, CALCA, MAPT, COL1A1
4MP:00036317.5MAPT, CALCA, GSK3B, NFKB1, CDH11, CDK5

Publications for Aneurysmal Bone Cysts

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53PubMed
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Articles related to Aneurysmal Bone Cysts:

(show top 50)    (show all 241)
idTitleAuthorsYear
1
Sclerotherapy with polidocanol for treatment of aneurysmal bone cysts. (24171682)
2013
2
Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts. (23455951)
2013
3
Aneurysmal bone cyst within fibrous dysplasia of the anterior skull base: continued intracranial extension after endoscopic resections requiring craniofacial approach with free tissue transfer reconstruction. (23435492)
2013
4
Giant cell tumor with secondary aneurysmal bone cyst: a unique presentation with an ossified extraosseous soft tissue mass. (23708046)
2013
5
Variable histopathological features of 6 cases of aneurysmal bone cysts developed in the jaws: review of the literature. (21454083)
2012
6
Active aneurysmal bone cysts in children: possible evolution after biopsy. (23904901)
2012
7
Giant pediatric aneurysmal bone cysts of the occipital bone: case report and review of the literature. (21723459)
2011
8
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
9
Fibrous dysplasia and aneurysmal bone cyst of the skull base presenting with blindness: a report of a rare locally aggressive example. (21396116)
2011
10
Factors associated with recurrence of primary aneurysmal bone cysts: is argon beam coagulation an effective adjuvant treatment? (22048101)
2011
11
Secondary aneurysmal bone cyst in fibrous dysplasia of the proximal femur. (19472953)
2009
12
Monostotic fibrous dysplasia of a lumbar vertebral body with secondary aneurysmal bone cyst formation: a case report. (19830140)
2009
13
Aneurysmal bone cysts of the jaws. (19233862)
2009
14
Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor. (19829276)
2009
15
Radiology corner. Answer to last month's radiology case and image: chondroblastoma with secondary aneurysmal bone cyst. (18333502)
2008
16
Frequency of USP6 rearrangements in myositis ossificans, brown tumor, and cherubism: molecular cytogenetic evidence that a subset of "myositis ossificans-like lesions" are the early phases in the formation of soft-tissue aneurysmal bone cyst. (18265974)
2008
17
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
18
Bone matrix therapy for aneurysmal bone cysts. (16037557)
2005
19
Aneurysmal bone cysts in children: complications of fibrosing agent injection. (15215542)
2004
20
Metachronous and multiple aneurysmal bone cysts: a rare variant of primary aneurysmal bone cysts. (15024646)
2004
21
Aneurysmal bone cyst arising from fibrous dysplasia of the frontal bone (2004:2b). (15162799)
2004
22
Classic adamantinoma with osteofibrous dysplasia-like foci and secondary aneurysmal bone cyst. (12574919)
2003
23
Treatment of chondroblastoma of the calcaneus with a secondary aneurysmal bone cyst using endoscopic curettage without bone grafting. (11951204)
2002
24
Surface aneurysmal bone cysts: a pictorial review. (11868083)
2002
25
Treatment of aneurysmal bone cysts with saucerization and bone marrow injection in children. (10413010)
1999
26
Multifocal polyostotic aneurysmal bone cysts in a llama. (9074685)
1997
27
Arterial embolization of aneurysmal bone cysts in children. (8731423)
1996
28
Unicameral and aneurysmal bone cysts. (8649741)
1996
29
Aneurysmal bone cyst presenting as Horner's syndrome. (7610419)
1995
30
Benign osteoblastoma associated with an aneurysmal bone cyst of the mandibular ramus and condyle. (8233421)
1993
31
Case report 729. Myositis ossificans and aneurysmal bone cyst. (1626294)
1992
32
Fluid levels in aneurysmal bone cysts. (1795415)
1991
33
Aneurysmal bone cysts: imaging findings and embolotherapy. (2750623)
1989
34
Aneurysmal bone cysts of the jaws: a case study and review of the literature. (3475661)
1987
35
Immunocytochemical markers (endothelial and histiocytic) and ultrastructure of primary aneurysmal bone cysts. (3080364)
1986
36
Aneurysmal bone cysts of the pelvis. (3535735)
1986
37
Aneurysmal bone cysts of the patella secondary to chondroblastoma. Case reports. (3966195)
1985
38
Aneurysmal bone cysts of the spine. (4018962)
1985
39
Concurrent osteoblastoma and aneurysmal bone cyst of the ethmoid sinus: case report. (4053663)
1985
40
Fluid levels in aneurysmal bone cysts: a CT feature. (6609547)
1984
41
Bilateral aneurysmal bone cysts of the maxilla. (6936531)
1981
42
Aneurysmal bone cysts with emphasis on roentgenologic diagnosis. (7320427)
1981
43
Aneurysmal bone cysts occurring in the metacarpals: a report of three cases. (722033)
1978
44
Aneurysmal bone cysts: a clinicopathological study of 105 cases. (265751)
1977
45
Aneurysmal bone cysts. (1193666)
1975
46
Aneurysmal bone cysts penetrating the tibial epiphysis after curettage. (5100168)
1971
47
Aneurysmal bone cysts of the jaws. (5243134)
1968
48
ANEURYSMAL BONE CYSTS OF THE MANDIBLE; REPORT OF A CASE. (14199580)
1964
49
A possible case of multiple aneurysmal bone cysts. (14487445)
1962
50
Aneurysmal bone cysts of spine. (13405746)
1957

Variations for Aneurysmal Bone Cysts

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Expression for genes affiliated with Aneurysmal Bone Cysts

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for genes affiliated with Aneurysmal Bone Cysts

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51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 5Cell Signaling Technology, 61Thomson Reuters, 56Reactome
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Pathways related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GSK3B, MAPT
29.5NFKB1, GSK3B, MAPT
39.3MAPT, GSK3B, CDK5
4
Show member pathways
Alzheimers Disease39
9.3MAPT, GSK3B, CDK5
59.3MAPT, GSK3B, CDK5
69.3CDK5, GSK3B, MAPT
79.3CDK5, GSK3B, MAPT
89.2CDK5, NFKB1, GSK3B
9
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.2CDK5, NFKB1, GSK3B
10
Show member pathways
9.2SLCO4A1, SLCO1A2, SLCO3A1
119.0CDH11, NFKB1, GSK3B
12
Show member pathways
8.9MAPT, GSK3B, NFKB1, CDK5
138.9CDK5, NFKB1, GSK3B, MAPT
148.9CDK5, NFKB1, GSK3B, MAPT

Compounds for genes affiliated with Aneurysmal Bone Cysts

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25HMDB, 46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR
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Compounds related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1Chenodeoxycholic acid disulfate2510.1SLCO4A1, SLCO1A2
27a-Hydroxy-5b-cholanic acid2510.1SLCO1A2, SLCO4A1
3Chenodeoxycholic acid sulfate2510.1SLCO1A2, SLCO4A1
4Bisnorcholic acid2510.1SLCO1A2, SLCO4A1
5Chenodeoxycholic acid 3-sulfate2510.1SLCO1A2, SLCO4A1
67a-Hydroxy-3-oxo-5b-cholanoic acid2510.1SLCO4A1, SLCO1A2
77-Hydroxy-3-oxocholanoic acid2510.1SLCO4A1, SLCO1A2
87-Ketodeoxycholic acid2510.1SLCO1A2, SLCO4A1
97-Sulfocholic acid2510.1SLCO1A2, SLCO4A1
107a,12a-Dihydroxy-3-oxo-4-cholenoic acid2510.1SLCO1A2, SLCO4A1
117a,12b-dihydroxy-5b-Cholan-24-oic acid2510.1SLCO1A2, SLCO4A1
12Coprocholic acid2510.1SLCO1A2, SLCO4A1
13Sulfolithocholic acid2510.1SLCO4A1, SLCO1A2
14Trihydroxycoprostanoic acid2510.1SLCO1A2, SLCO4A1
15Ursocholic acid2510.1SLCO1A2, SLCO4A1
16Ursodeoxycholic acid 3-sulfate2510.1SLCO1A2, SLCO4A1
17Varanic acid2510.1SLCO1A2, SLCO4A1
18Nutriacholic acid2510.1SLCO4A1, SLCO1A2
19Deoxycholic acid disulfate2510.1SLCO1A2, SLCO4A1
20Glycochenodeoxycholate-3-sulfate2510.1SLCO1A2, SLCO4A1
21Hyocholic acid2510.1SLCO1A2, SLCO4A1
22Murocholic acid2510.1SLCO1A2, SLCO4A1
233,7-Dihydroxy-12-oxocholanoic acid2510.1SLCO4A1, SLCO1A2
243-Oxo-4,6-choladienoic acid2510.0SLCO1A2, SLCO4A1
253-Oxocholic acid2510.0SLCO1A2, SLCO4A1
263-Sulfodeoxycholic acid2510.0SLCO1A2, SLCO4A1
273a,12b-Dihydroxy-5b-cholanoic acid2510.0SLCO1A2, SLCO4A1
28alsterpaullone46 1211.0CDK5, GSK3B
292b,3a,7a-Trihydroxy-5b-cholanoic acid2510.0SLCO4A1, SLCO1A2
30(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid2510.0SLCO1A2, SLCO4A1
311,3,12-Trihydroxycholan-24-oic acid2510.0SLCO1A2, SLCO4A1
321b-Hydroxycholic acid2510.0SLCO1A2, SLCO4A1
332b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2510.0SLCO1A2, SLCO4A1
343a,4b,12a-Trihydroxy-5b-cholanoic acid2510.0SLCO1A2, SLCO4A1
353b,12a-Dihydroxy-5a-cholanoic acid259.9SLCO1A2, SLCO4A1
363b,12a-Dihydroxy-5b-cholanoic acid259.9SLCO1A2, SLCO4A1
37butyrolactone i469.9CDK5, MAPT
383b,12b-Dihydroxy-5b-cholanoic acid259.9SLCO1A2, SLCO4A1
393b-Hydroxy-5-cholenoic acid259.9SLCO1A2, SLCO4A1
406a,12a-Dihydroxylithocholic acid259.9SLCO1A2, SLCO4A1
413a,7b,12b-Trihydroxy-5b-cholanoic acid259.8SLCO4A1, SLCO1A2
423a,7b,12a-Trihydroxy-5a-Cholanoic acid259.8SLCO4A1, SLCO1A2
43lithium46 52 25 1212.7CDK5, GSK3B, MAPT
443a,4b,7a,12a-Tetrahydroxy-5b-cholanoic acid259.7SLCO1A2, SLCO4A1
453a,7a-Dihydroxycholanoic acid259.7SLCO1A2, SLCO4A1
46[3h]estrone-3-sulphate309.6SLCO3A1, SLCO1A2, SLCO4A1
47conjugated estrogens52 1210.6SLCO4A1, SLCO3A1, SLCO1A2
48Taurocholic acid25 1210.6SLCO1A2, SLCO3A1, SLCO4A1
493a,7a,12a,19-Tetrahydroxy-5b-cholanoic acid259.6SLCO1A2, SLCO4A1
503a,7a,12b-Trihydroxy-5b-cholanoic acid259.4SLCO1A2, SLCO4A1

GO Terms for genes affiliated with Aneurysmal Bone Cysts

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17Gene Ontology
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Cellular components related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.3CDK5, GSK3B, CALCA
2growth coneGO:0304269.2CDK5, GSK3B, MAPT
3plasma membraneGO:0058867.0USP6, MAPT, GSK3B, CDH11, SLCO4A1, SLCO1A2

Biological processes related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein bindingGO:0320929.6CDK5, GSK3B
2cellular response to mechanical stimulusGO:0712609.5NFKB1, GSK3B, COL1A1
3axon extensionGO:0486759.5MAPT, CDK5
4hippocampus developmentGO:0217669.3CDK5, GSK3B
5sodium-independent organic anion transportGO:0432529.2SLCO3A1, SLCO1A2, SLCO4A1

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:0163019.6CDK5, GSK3B
2tau-protein kinase activityGO:0503219.3CDK5, GSK3B

Products for genes affiliated with Aneurysmal Bone Cysts

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Sources for Aneurysmal Bone Cysts

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet