MCID: ANR009
MIFTS: 41

Aneurysmal Bone Cysts malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Aneurysmal Bone Cysts

Aliases & Descriptions for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 54 38 50 13
Aneurysmal Bone Cyst 56 29
Bone Cysts, Aneurysmal 69
Bone Cysts Aneurysmal 52

Classifications:



External Ids:

OMIM 54 606179
Orphanet 56 ORPHA480553
ICD10 33 M85.5

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as aneurysmal bone cyst, is related to aneurysm and chondroblastoma, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. Affiliated tissues include Bone, bone and endothelial.

Wikipedia : 71 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

Description from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 aneurysm 10.8
2 chondroblastoma 10.3
3 fibrous dysplasia 10.2
4 osteoblastoma 10.2
5 fibroma 10.1
6 giant cell tumor 10.1
7 extrahepatic bile duct leiomyosarcoma 10.1 TNFRSF11A TNFSF11
8 osteopetrosis, autosomal recessive 7 10.1 TNFRSF11A TNFSF11
9 atrial heart septal defect 10.1 CALCA TNFRSF11A
10 ossifying fibroma 10.1
11 hepatic fibrosis renal cysts mental retardation 10.1 TNFRSF11A TNFSF11
12 epilepsy, idiopathic generalized 14 10.0 TNFRSF11A TNFSF11
13 polyomavirus allograft nephropathy 10.0 TNFRSF11A TNFSF11
14 bulbomembranous urethral cancer 10.0 TNFRSF11A TNFSF11
15 cervicitis 10.0
16 microcephaly 10, primary, autosomal recessive 10.0 TNFRSF11A TNFSF11
17 phka2-related phosphorylase kinase deficiency 9.9 CALCA TNFRSF11A TNFSF11
18 birk-barel mental retardation dysmorphism syndrome 9.9 CALCA TNFRSF11A TNFSF11
19 giant cell reparative granuloma 9.9
20 maroteaux stanescu cousin syndrome 9.9 CALCA TNFRSF11A TNFSF11
21 glossitis 9.9 CALCA TNFRSF11A TNFSF11
22 dysbaric osteonecrosis 9.9 CALCA TNFRSF11A TNFSF11
23 ischemic bone disease 9.9 CALCA TNFRSF11A TNFSF11
24 preretinal fibrosis 9.9 CALCA TNFRSF11A TNFSF11
25 bronchus cancer 9.9 TNFRSF11A TNFSF11
26 bladder papillary transitional cell neoplasm 9.9 CALCA TNFRSF11A TNFSF11
27 chondromyxoid fibroma 9.8
28 ameloblastoma 9.8
29 myositis 9.8
30 myositis ossificans 9.8
31 juvenile ossifying fibroma 9.8
32 cherubism 9.8
33 chondrosarcoma 9.8
34 bone fracture 9.6
35 thoracic outlet syndrome 9.6
36 monostotic fibrous dysplasia 9.6
37 hydrocephalus 9.6
38 histiocytosis 9.6
39 angiosarcoma 9.6
40 mesenchymal chondrosarcoma 9.6
41 clear cell chondrosarcoma 9.6
42 neuropathy 9.6
43 partial third-nerve palsy 9.6
44 exophthalmos 9.6
45 horner's syndrome 9.6
46 fasciitis 9.6
47 tooth resorption 9.6
48 enchondroma 9.6
49 obstructive hydrocephalus 9.6
50 endolymphatic sac tumor 9.6

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM:

606179

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Interventional clinical trials:


id Name Status NCT ID Phase
1 Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC) Recruiting NCT03066245 Phase 1, Phase 2

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

id Genetic test Affiliating Genes
1 Aneurysmal Bone Cysts 29

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

39
Bone, Endothelial, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 288)
id Title Authors Year
1
Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report. ( 27853880 )
2017
2
Treatment of aneurysmal bone cysts by percutaneous CT-guided injection of calcitonin and steroid. ( 27743037 )
2017
3
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. ( 27504302 )
2016
4
Conversion of Aneurysmal Bone Cyst into Fibrous Dysplasia: A Rare Pediatric Case Report. ( 27408470 )
2016
5
Giant Cell Tumor with Secondary Aneurysmal Bone Cyst Shows Heterogeneous Metabolic Pattern on (18)F-FDG PET/CT: A Case Report. ( 27994691 )
2016
6
Interest of Denosumab for the Treatment of Giant-cells Tumors and Aneurysmal Bone Cysts of the Spine. About Nine Cases. ( 27244112 )
2016
7
Selective arterial Embolisation of Aneurysmal Bone Cysts ofA the Sacrum: a promising Alternative to Surgery. ( 26695847 )
2016
8
How effective is embolization with N-2-butyl-cyanoacrylate for aneurysmal bone cysts? ( 27933423 )
2016
9
Craniospinal Polyostotic Fibrous Dysplasia, Aneurysmal Bone Cysts, and Chiari Type 1 Malformation Coexistence in a Patient with McCune-Albright Syndrome. ( 27161212 )
2016
10
Current management of aneurysmal bone cysts. ( 27778155 )
2016
11
Aneurysmal Bone Cyst Arising from the First Rib: A Rare Cause of Thoracic Outlet Syndrome. ( 28018833 )
2016
12
Radiotherapy for aneurysmal bone cysts : AA rare indication. ( 27957589 )
2016
13
A case report of granular cell ameloblastoma associated with aneurysmal bone cyst like features. ( 26538973 )
2015
14
Current Strategies for the Treatment of Aneurysmal Bone Cysts. ( 26793296 )
2015
15
Unusual localizations of unicameral bone cysts and aneurysmal bone cysts: A retrospective review of 451 cases. ( 26280957 )
2015
16
Percutaneous Doxycycline Treatment of Juxtaphyseal Aneurysmal Bone Cysts. ( 25985367 )
2015
17
Differential diagnostic value of "blue reticulated chondroid-like material" in aneurysmal bone cysts: a classic histopathologic analysis of 215 cases. ( 25972324 )
2015
18
Radiation Therapy for Aneurysmal Bone Cysts. ( 26165419 )
2015
19
Aneurysmal bone cyst with fibrous dysplasia resulting in partial third nerve palsy. ( 25863863 )
2015
20
Surgical treatment of active or aggressive aneurysmal bone cysts in children. ( 25812030 )
2015
21
A rare case of osteoblastoma associated to aneurysmal bone cyst of the spine. Case report. ( 26204456 )
2015
22
Aneurysmal Bone Cysts of the Hand, Wrist, andA Forearm. ( 26253603 )
2015
23
Psammous desmo-osteoblastoma with concomitant aneurysmal bone cyst of mandible. ( 26389053 )
2015
24
Aneurysmal bone cysts of the spine: treatment options and considerations. ( 25059450 )
2014
25
Destructive osteoblastoma with secondary aneurysmal bone cyst of cervical vertebra in an 11-year-old boy: case report. ( 24482719 )
2014
26
Aneurysmal bone cysts: denosumab extends its reach. ( 24837849 )
2014
27
Bipolar electric cauterization as adjuvant treatment after curettage of aneurysmal bone cysts of the hand. ( 24317236 )
2014
28
Juvenile psammomatoid ossifying fibroma with aneurysmal bone cyst in the posterior mandible. ( 25374619 )
2014
29
Assessment of 120 maxillofacial aneurysmal bone cysts: a nationwide quest to understand this enigma. ( 24931106 )
2014
30
Functional outcomes and quality of life following surgical treatment of aneurysmal bone cysts of the pelvis in children. ( 24817630 )
2014
31
Aneurysmal bone cysts: do simple treatments work? ( 24532435 )
2014
32
An endolymphatic sac tumor with imaging features of aneurysmal bone cysts: differential diagnostic considerations. ( 24881035 )
2014
33
Chondroblastoma of the patella with aneurysmal bone cyst. ( 24683664 )
2014
34
Aneurysmal bone cysts of the spine: two case reports. ( 25620988 )
2014
35
Treatments for primary aneurysmal bone cysts of the cervical spine: experience of 14 cases. ( 25430453 )
2014
36
USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. ( 23769422 )
2014
37
Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. ( 24664395 )
2014
38
Intraspinal dural-based primary osteoblastoma with aneurysmal bone cyst-like change. ( 24984761 )
2014
39
Effect of adjuvant therapies on recurrence in aneurysmal bone cysts. ( 25429574 )
2014
40
Targeting receptor-activator of nuclear kappaB ligand in aneurysmal bone cysts: verification of target and therapeutic response. ( 24726460 )
2014
41
Chondroblastoma with secondary aneurysmal bone cyst of the capitate. ( 24810829 )
2014
42
Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella. ( 24639947 )
2014
43
Is curettage and high-speed burring sufficient treatment for aneurysmal bone cysts? ( 25048282 )
2014
44
Aneurysmal bone cyst within fibrous dysplasia of the anterior skull base: continued intracranial extension after endoscopic resections requiring craniofacial approach with free tissue transfer reconstruction. ( 23435492 )
2013
45
Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report. ( 23670673 )
2013
46
Gastrointestinal stromal tumor of the ampulla of Vater with osteoclastic giant cells, osteoid-like matrix deposition, and aneurysmal bone cyst-like features. ( 23036260 )
2013
47
Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts. ( 23455951 )
2013
48
Rare pediatric presentation of aneurysmal bone cyst with trabecular juvenile ossifying fibroma and ossifying fibroma. ( 23305772 )
2013
49
Giant cell tumor of bone with secondary aneurysmal bone cyst-like change producing I^-human chorionic gonadotropin. ( 24362936 )
2013
50
Aneurysmal bone cysts. ( 24049942 )
2013

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.36 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
2 growth cone GO:0030426 9.33 CDK5 GSK3B MAPT
3 neuronal cell body GO:0043025 9.26 CALCA CDK5 GSK3B MAPT
4 membrane GO:0016020 10 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.61 CDH11 TNFRSF11A TNFSF11
2 positive regulation of axon extension GO:0045773 9.51 GSK3B MAPT
3 monocyte chemotaxis GO:0002548 9.5 CALCA TNFRSF11A TNFSF11
4 positive regulation of receptor activity GO:2000273 9.49 CDK5 MAPT
5 osteoclast differentiation GO:0030316 9.48 TNFRSF11A TNFSF11
6 mammary gland alveolus development GO:0060749 9.46 TNFRSF11A TNFSF11
7 regulation of calcium-mediated signaling GO:0050848 9.4 GBP1 MAPT
8 TNFSF11-mediated signaling pathway GO:0071847 9.37 TNFRSF11A TNFSF11
9 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.26 TNFRSF11A TNFSF11
10 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFRSF11A TNFSF11
11 positive regulation of neuron death GO:1901216 9.13 CDK5 GSK3B MAPT
12 sodium-independent organic anion transport GO:0043252 8.8 SLCO1A2 SLCO3A1 SLCO4A1

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Hsp90 protein binding GO:0051879 9.16 GBP1 MAPT
2 cytokine binding GO:0019955 8.96 GBP1 TNFRSF11A
3 tau-protein kinase activity GO:0050321 8.62 CDK5 GSK3B

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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