MCID: ANR009
MIFTS: 52

Aneurysmal Bone Cysts malady

Rare diseases, Bone diseases categories

Summaries for Aneurysmal Bone Cysts

About this section


Wikipedia:65 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

MalaCards based summary: Aneurysmal Bone Cysts, also known as bone cysts, aneurysmal, is related to cherubism and aneurysm. An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal bone cysts), and among its related pathways are Regulation of Microtubule Cytoskeleton and LPA receptor mediated events. The compounds 7a-Hydroxy-5b-cholanic acid and 7b,12a-Dihydroxycholanoic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and bone marrow, and related mouse phenotypes are normal and behavior/neurological.

Description from OMIM:47 606179

Aliases & Classifications for Aneurysmal Bone Cysts

About this section

Aneurysmal Bone Cysts, Aliases & Descriptions:

Name: Aneurysmal Bone Cysts 47 32 11 43
Bone Cysts, Aneurysmal 62
 
Bone Cysts Aneurysmal 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


External Ids:

OMIM47 606179
ICD1027 M85.5

Related Diseases for Aneurysmal Bone Cysts

About this section

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to aneurysmal bone cysts

Symptoms for Aneurysmal Bone Cysts

About this section


Clinical features from OMIM:

606179

Drugs & Therapeutics for Aneurysmal Bone Cysts

About this section

Drug clinical trials:

Search ClinicalTrials for Aneurysmal Bone Cysts

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

About this section

Anatomical Context for Aneurysmal Bone Cysts

About this section

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

33
Bone, Endothelial, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Aneurysmal Bone Cysts or affiliated genes

About this section

MGI Mouse Phenotypes related to Aneurysmal Bone Cysts:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.0COL1A1, MAPT, CALCA, GSK3B, NFKB1, CDK5
2MP:00053867.8OMD, COL1A1, MAPT, CALCA, GSK3B, NFKB1
3MP:00107717.8CDK5, CDH11, NFKB1, CALCA, MAPT, COL1A1
4MP:00036317.5MAPT, CALCA, GSK3B, NFKB1, CDH11, CDK5

Publications for Aneurysmal Bone Cysts

About this section

Articles related to Aneurysmal Bone Cysts:

(show top 50)    (show all 265)
idTitleAuthorsYear
1
Aneurysmal bone cyst with fibrous dysplasia resulting in partial third nerve palsy. (25863863)
2015
2
Aneurysmal bone cysts: do simple treatments work? (24532435)
2014
3
An endolymphatic sac tumor with imaging features of aneurysmal bone cysts: differential diagnostic considerations. (24881035)
2014
4
Aneurysmal bone cysts: denosumab extends its reach. (24837849)
2014
5
Sclerotherapy with polidocanol for treatment of aneurysmal bone cysts. (24171682)
2013
6
Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts. (23455951)
2013
7
Aneurysmal bone cyst within fibrous dysplasia of the anterior skull base: continued intracranial extension after endoscopic resections requiring craniofacial approach with free tissue transfer reconstruction. (23435492)
2013
8
Variable histopathological features of 6 cases of aneurysmal bone cysts developed in the jaws: review of the literature. (21454083)
2012
9
Active aneurysmal bone cysts in children: possible evolution after biopsy. (23904901)
2012
10
Giant pediatric aneurysmal bone cysts of the occipital bone: case report and review of the literature. (21723459)
2011
11
Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. (21514167)
2011
12
Fibrous dysplasia and aneurysmal bone cyst of the skull base presenting with blindness: a report of a rare locally aggressive example. (21396116)
2011
13
Factors associated with recurrence of primary aneurysmal bone cysts: is argon beam coagulation an effective adjuvant treatment? (22048101)
2011
14
Secondary aneurysmal bone cyst in fibrous dysplasia of the proximal femur. (19472953)
2009
15
A cherubism with aneurysmal bone cyst. (19386735)
2009
16
Monostotic fibrous dysplasia of a lumbar vertebral body with secondary aneurysmal bone cyst formation: a case report. (19830140)
2009
17
Aneurysmal bone cysts of the jaws. (19233862)
2009
18
Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor. (19829276)
2009
19
Radiology corner. Answer to last month's radiology case and image: chondroblastoma with secondary aneurysmal bone cyst. (18333502)
2008
20
Frequency of USP6 rearrangements in myositis ossificans, brown tumor, and cherubism: molecular cytogenetic evidence that a subset of "myositis ossificans-like lesions" are the early phases in the formation of soft-tissue aneurysmal bone cyst. (18265974)
2008
21
Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. (16328381)
2006
22
Bone matrix therapy for aneurysmal bone cysts. (16037557)
2005
23
Aneurysmal bone cysts in children: complications of fibrosing agent injection. (15215542)
2004
24
Metachronous and multiple aneurysmal bone cysts: a rare variant of primary aneurysmal bone cysts. (15024646)
2004
25
Aneurysmal bone cyst arising from fibrous dysplasia of the frontal bone (2004:2b). (15162799)
2004
26
Classic adamantinoma with osteofibrous dysplasia-like foci and secondary aneurysmal bone cyst. (12574919)
2003
27
Treatment of chondroblastoma of the calcaneus with a secondary aneurysmal bone cyst using endoscopic curettage without bone grafting. (11951204)
2002
28
Surface aneurysmal bone cysts: a pictorial review. (11868083)
2002
29
Treatment of aneurysmal bone cysts with saucerization and bone marrow injection in children. (10413010)
1999
30
Arterial embolization of aneurysmal bone cysts in children. (8731423)
1996
31
Unicameral and aneurysmal bone cysts. (8649741)
1996
32
Aneurysmal bone cyst presenting as Horner's syndrome. (7610419)
1995
33
Benign osteoblastoma associated with an aneurysmal bone cyst of the mandibular ramus and condyle. (8233421)
1993
34
Case report 729. Myositis ossificans and aneurysmal bone cyst. (1626294)
1992
35
Fluid levels in aneurysmal bone cysts. (1795415)
1991
36
Immunocytochemical markers (endothelial and histiocytic) and ultrastructure of primary aneurysmal bone cysts. (3080364)
1986
37
Aneurysmal bone cysts of the patella secondary to chondroblastoma. Case reports. (3966195)
1985
38
Aneurysmal bone cysts of the spine. (4018962)
1985
39
Concurrent osteoblastoma and aneurysmal bone cyst of the ethmoid sinus: case report. (4053663)
1985
40
Fluid levels in aneurysmal bone cysts: a CT feature. (6609547)
1984
41
Bilateral aneurysmal bone cysts of the maxilla. (6936531)
1981
42
Aneurysmal bone cysts with emphasis on roentgenologic diagnosis. (7320427)
1981
43
Aneurysmal bone cysts occurring in the metacarpals: a report of three cases. (722033)
1978
44
Aneurysmal bone cysts: a clinicopathological study of 105 cases. (265751)
1977
45
Aneurysmal bone cysts. (1193666)
1975
46
Aneurysmal bone cysts penetrating the tibial epiphysis after curettage. (5100168)
1971
47
Aneurysmal bone cysts of the jaws. (5243134)
1968
48
ANEURYSMAL BONE CYSTS OF THE MANDIBLE; REPORT OF A CASE. (14199580)
1964
49
A possible case of multiple aneurysmal bone cysts. (14487445)
1962
50
Aneurysmal bone cysts of spine. (13405746)
1957

Variations for Aneurysmal Bone Cysts

About this section

Expression for genes affiliated with Aneurysmal Bone Cysts

About this section

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for genes affiliated with Aneurysmal Bone Cysts

About this section

Pathways related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GSK3B, MAPT
29.5MAPT, GSK3B, NFKB1
39.3MAPT, GSK3B, CDK5
49.3MAPT, GSK3B, CDK5
59.3CDK5, MAPT, GSK3B
6
Show member pathways
Alzheimers Disease38
9.3CDK5, MAPT, GSK3B
79.3CDK5, MAPT, GSK3B
89.2GSK3B, CDK5, NFKB1
9
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.2CDK5, NFKB1, GSK3B
10
Show member pathways
9.2SLCO4A1, SLCO1A2, SLCO3A1
119.0CDH11, NFKB1, GSK3B
12
Show member pathways
8.9MAPT, GSK3B, CDK5, NFKB1
138.9CDK5, GSK3B, MAPT, NFKB1
148.9MAPT, CDK5, NFKB1, GSK3B

Compounds for genes affiliated with Aneurysmal Bone Cysts

About this section
Sources:
26HMDB, 45Novoseek, 13DrugBank, 51PharmGKB, 30IUPHAR
See all sources

Compounds related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
17a-Hydroxy-5b-cholanic acid2610.1SLCO1A2, SLCO4A1
27b,12a-Dihydroxycholanoic acid2610.1SLCO1A2, SLCO4A1
3Allochenodeoxycholic acid2610.1SLCO1A2, SLCO4A1
4Allocholic acid2610.1SLCO1A2, SLCO4A1
5Coprocholic acid2610.1SLCO1A2, SLCO4A1
67a-Hydroxy-3-oxo-5b-cholanoic acid2610.1SLCO4A1, SLCO1A2
73b,7a,12a-Trihydroxy-5b-cholanoic acid2610.1SLCO4A1, SLCO1A2
87-Ketodeoxycholic acid2610.1SLCO1A2, SLCO4A1
97-Sulfocholic acid2610.1SLCO1A2, SLCO4A1
107a,12a-Dihydroxy-3-oxo-4-cholenoic acid2610.1SLCO1A2, SLCO4A1
117a,12b-dihydroxy-5b-Cholan-24-oic acid2610.1SLCO1A2, SLCO4A1
12Deoxycholic acid disulfate2610.1SLCO1A2, SLCO4A1
13Isohyodeoxycholic acid2610.1SLCO4A1, SLCO1A2
14Trihydroxycoprostanoic acid2610.1SLCO1A2, SLCO4A1
15Ursocholic acid2610.1SLCO1A2, SLCO4A1
16Ursodeoxycholic acid 3-sulfate2610.1SLCO1A2, SLCO4A1
17Varanic acid2610.1SLCO1A2, SLCO4A1
18Isodeoxycholic acid2610.1SLCO4A1, SLCO1A2
19Glycochenodeoxycholate-3-sulfate2610.1SLCO1A2, SLCO4A1
20Hyocholic acid2610.1SLCO1A2, SLCO4A1
21Hyodeoxycholic acid2610.1SLCO1A2, SLCO4A1
22Isoallolithocholic acid2610.1SLCO1A2, SLCO4A1
23(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid2610.1SLCO1A2, SLCO4A1
243-Oxo-4,6-choladienoic acid2610.1SLCO4A1, SLCO1A2
253-Oxocholic acid2610.0SLCO1A2, SLCO4A1
263-Sulfodeoxycholic acid2610.0SLCO1A2, SLCO4A1
273a,12b-Dihydroxy-5b-cholanoic acid2610.0SLCO1A2, SLCO4A1
283a,4b,12a-Trihydroxy-5b-cholanoic acid2610.0SLCO1A2, SLCO4A1
29alsterpaullone45 1311.0GSK3B, CDK5
3012b-Hydroxy-5b-cholanoic acid2610.0SLCO4A1, SLCO1A2
311,3,12-Trihydroxycholan-24-oic acid2610.0SLCO1A2, SLCO4A1
321,3,7,12-Tetrahydroxycholan-24-oic acid2610.0SLCO1A2, SLCO4A1
3312-Ketodeoxycholic acid2610.0SLCO1A2, SLCO4A1
3412a-Hydroxy-3-oxocholadienic acid2610.0SLCO1A2, SLCO4A1
353a,4b,7a,12a-Tetrahydroxy-5b-cholanoic acid2610.0SLCO1A2, SLCO4A1
363b,12a-Dihydroxy-5a-cholanoic acid269.9SLCO1A2, SLCO4A1
373b,12a-Dihydroxy-5b-cholanoic acid269.9SLCO1A2, SLCO4A1
383b,12b-Dihydroxy-5b-cholanoic acid269.9SLCO1A2, SLCO4A1
393b,4b,7a,12a-Tetrahydroxy-5b-cholanoic acid269.9SLCO1A2, SLCO4A1
403b,7a,12a-Trihydroxy-5a-Cholanoic acid269.9SLCO1A2, SLCO4A1
413a,7b,12b-Trihydroxy-5b-cholanoic acid269.8SLCO4A1, SLCO1A2
423a,7b,12a-Trihydroxy-5a-Cholanoic acid269.8SLCO4A1, SLCO1A2
43lithium45 51 26 1312.7CDK5, MAPT, GSK3B
443a,4b,7a-Trihydroxy-5b-cholanoic acid269.7SLCO1A2, SLCO4A1
453a,6b,7b,12a-Tetrahydroxy-5b-cholanoic acid269.7SLCO1A2, SLCO4A1
46[3h]estrone-3-sulphate309.6SLCO3A1, SLCO1A2, SLCO4A1
47conjugated estrogens51 1310.6SLCO3A1, SLCO4A1, SLCO1A2
48Taurocholic acid26 1310.6SLCO4A1, SLCO1A2, SLCO3A1
493a,6a,7b-Trihydroxy-5b-cholanoic acid269.6SLCO1A2, SLCO4A1
503a,6b,7a,12a-Tetrahydroxy-5b-cholanoic acid269.4SLCO1A2, SLCO4A1

GO Terms for genes affiliated with Aneurysmal Bone Cysts

About this section

Cellular components related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430259.3CDK5, GSK3B, CALCA
2growth coneGO:00304269.2MAPT, GSK3B, CDK5
3plasma membraneGO:00058867.0SLCO3A1, USP6, MAPT, GSK3B, CDH11, SLCO4A1

Biological processes related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hippocampus developmentGO:00217669.6GSK3B, CDK5
2cellular response to mechanical stimulusGO:00712609.5GSK3B, NFKB1, COL1A1
3axon extensionGO:00486759.5CDK5, MAPT
4positive regulation of protein bindingGO:00320929.3GSK3B, CDK5
5sodium-independent organic anion transportGO:00432529.2SLCO4A1, SLCO3A1, SLCO1A2

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:00163019.6CDK5, GSK3B
2tau-protein kinase activityGO:00503219.3CDK5, GSK3B

Products for genes affiliated with Aneurysmal Bone Cysts

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Aneurysmal Bone Cysts

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet