MCID: ANR009
MIFTS: 40

Aneurysmal Bone Cysts

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Aneurysmal Bone Cysts

MalaCards integrated aliases for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 54 38 50 29 13
Bone Cysts, Aneurysmal 69
Bone Cysts Aneurysmal 52
Aneurysmal Bone Cyst 56

Classifications:

Orphanet: 56  
Rare bone diseases


External Ids:

OMIM 54 606179
Orphanet 56 ORPHA480553
ICD10 33 M85.5

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as bone cysts, aneurysmal, is related to aneurysm and polyembryoma, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. Affiliated tissues include Bone, bone and endothelial.

Wikipedia : 72 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

Description from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 aneurysm 10.8
2 polyembryoma 10.4 TNFRSF11A TNFSF11
3 larynx leiomyosarcoma 10.3 TNFRSF11A TNFSF11
4 paget disease of bone 2, early-onset 10.3 TNFRSF11A TNFSF11
5 hennekam van der horst syndrome 10.3 TNFRSF11A TNFSF11
6 chondroblastoma 10.3
7 spinocerebellar ataxia 4 10.3 TNFRSF11A TNFSF11
8 metaphyseal anadysplasia 2 10.2 TNFRSF11A TNFSF11
9 fibrous dysplasia 10.2
10 lower clivus meningioma 10.2 TNFRSF11A TNFSF11
11 osteoblastoma 10.2
12 giant cell tumor 10.1
13 fibroma 10.1
14 bronchus cancer 10.1 TNFRSF11A TNFSF11
15 cholangitis 10.1 SLCO1A2 SLCO4A1
16 ossifying fibroma 10.1
17 atrial heart septal defect 10.0 CALCA TNFRSF11A USP6
18 cervicitis 10.0
19 giant cell reparative granuloma 10.0
20 tibial hemimelia 9.9 CALCA TNFRSF11A TNFSF11
21 piebald trait, kit-related 9.9 GSK3B MAPT
22 meckel syndrome 10 9.9 GSK3B MAPT
23 glossitis 9.9 CALCA TNFRSF11A TNFSF11
24 physical disorder 9.9 CALCA TNFRSF11A TNFSF11
25 bone deterioration disease 9.9 CALCA TNFRSF11A TNFSF11
26 chondromyxoid fibroma 9.8
27 preretinal fibrosis 9.8 CALCA TNFRSF11A TNFSF11
28 bacillary angiomatosis 9.8 CALCA TNFSF11
29 schizoaffective disorder 9.8 CALCA TNFRSF11A TNFSF11
30 bone resorption disease 9.8 TNFRSF11A TNFSF11
31 myositis 9.8
32 myositis ossificans 9.8
33 cherubism 9.8
34 juvenile ossifying fibroma 9.8
35 chondrosarcoma 9.8
36 ameloblastoma 9.8
37 partial third-nerve palsy 9.6
38 neuropathy 9.6
39 horner's syndrome 9.6
40 exophthalmos 9.6
41 tooth resorption 9.6
42 fasciitis 9.6
43 obstructive hydrocephalus 9.6
44 enchondroma 9.6
45 gastrointestinal stromal tumor 9.6
46 endolymphatic sac tumor 9.6
47 osteofibrous dysplasia 9.6
48 endotheliitis 9.6
49 focal dermal hypoplasia 9.6
50 bone fracture 9.6

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM:

606179

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC) Recruiting NCT03066245 Phase 1, Phase 2

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

id Genetic test Affiliating Genes
1 Aneurysmal Bone Cysts 29

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

39
Bone, Endothelial, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 296)
id Title Authors Year
1
Treatment of Aneurysmal Bone Cysts with Bioactive Glass in Children. ( 28950789 )
2017
2
Cervical Spine Aneurysmal Bone Cysts in the Pediatric Population: A Systematic Review of the Literature. ( 28605734 )
2017
3
Giant Cell Tumor of the Ribs and Aneurysmal Bone Cyst Presenting With Hemothorax in a Child. ( 28859035 )
2017
4
Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report. ( 27853880 )
2017
5
Gene fusions PAFAH1B1-USP6 and RUNX2-USP6 in aneurysmal bone cysts identified by next generation sequencing. ( 28449806 )
2017
6
Diagnosing and discriminating between primary and secondary aneurysmal bone cysts. ( 28454393 )
2017
7
Treatment of aneurysmal bone cysts by percutaneous CT-guided injection of calcitonin and steroid. ( 27743037 )
2017
8
Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology. ( 28193096 )
2017
9
Current management of aneurysmal bone cysts. ( 27778155 )
2016
10
Aneurysmal Bone Cyst Arising from the First Rib: A Rare Cause of Thoracic Outlet Syndrome. ( 28018833 )
2016
11
How effective is embolization with N-2-butyl-cyanoacrylate for aneurysmal bone cysts? ( 27933423 )
2016
12
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. ( 27504302 )
2016
13
Radiotherapy for aneurysmal bone cysts : AA rare indication. ( 27957589 )
2016
14
Giant Cell Tumor with Secondary Aneurysmal Bone Cyst Shows Heterogeneous Metabolic Pattern on (18)F-FDG PET/CT: A Case Report. ( 27994691 )
2016
15
Giant Cell Reparative Granuloma Mimicking Aneurysmal Bone Cyst in Proximal Phalanx of Toe. ( 28435549 )
2016
16
Interest of Denosumab for the Treatment of Giant-cells Tumors and Aneurysmal Bone Cysts of the Spine. About Nine Cases. ( 27244112 )
2016
17
Craniospinal Polyostotic Fibrous Dysplasia, Aneurysmal Bone Cysts, and Chiari Type 1 Malformation Coexistence in a Patient with McCune-Albright Syndrome. ( 27161212 )
2016
18
Conversion of Aneurysmal Bone Cyst into Fibrous Dysplasia: A Rare Pediatric Case Report. ( 27408470 )
2016
19
Unicameral (simple) and aneurysmal bone cysts: the effect of insufficient curettage on recurrence. ( 28154666 )
2016
20
Selective arterial Embolisation of Aneurysmal Bone Cysts ofA the Sacrum: a promising Alternative to Surgery. ( 26695847 )
2016
21
Psammous desmo-osteoblastoma with concomitant aneurysmal bone cyst of mandible. ( 26389053 )
2015
22
Aneurysmal bone cyst with fibrous dysplasia resulting in partial third nerve palsy. ( 25863863 )
2015
23
Surgical treatment of active or aggressive aneurysmal bone cysts in children. ( 25812030 )
2015
24
Aneurysmal Bone Cysts of the Hand, Wrist, andA Forearm. ( 26253603 )
2015
25
A case report of granular cell ameloblastoma associated with aneurysmal bone cyst like features. ( 26538973 )
2015
26
Unusual localizations of unicameral bone cysts and aneurysmal bone cysts: A retrospective review of 451 cases. ( 26280957 )
2015
27
Differential diagnostic value of "blue reticulated chondroid-like material" in aneurysmal bone cysts: a classic histopathologic analysis of 215 cases. ( 25972324 )
2015
28
A rare case of osteoblastoma associated to aneurysmal bone cyst of the spine. Case report. ( 26204456 )
2015
29
Percutaneous Doxycycline Treatment of Juxtaphyseal Aneurysmal Bone Cysts. ( 25985367 )
2015
30
Current Strategies for the Treatment of Aneurysmal Bone Cysts. ( 26793296 )
2015
31
Radiation Therapy for Aneurysmal Bone Cysts. ( 26165419 )
2015
32
Treatments for primary aneurysmal bone cysts of the cervical spine: experience of 14 cases. ( 25430453 )
2014
33
Bipolar electric cauterization as adjuvant treatment after curettage of aneurysmal bone cysts of the hand. ( 24317236 )
2014
34
Chondroblastoma with secondary aneurysmal bone cyst of the capitate. ( 24810829 )
2014
35
Aneurysmal bone cysts: denosumab extends its reach. ( 24837849 )
2014
36
USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. ( 23769422 )
2014
37
Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella. ( 24639947 )
2014
38
Aneurysmal bone cysts of the spine: two case reports. ( 25620988 )
2014
39
Juvenile psammomatoid ossifying fibroma with aneurysmal bone cyst in the posterior mandible. ( 25374619 )
2014
40
Chondroblastoma of the patella with aneurysmal bone cyst. ( 24683664 )
2014
41
Intraspinal dural-based primary osteoblastoma with aneurysmal bone cyst-like change. ( 24984761 )
2014
42
An endolymphatic sac tumor with imaging features of aneurysmal bone cysts: differential diagnostic considerations. ( 24881035 )
2014
43
Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. ( 24664395 )
2014
44
Is curettage and high-speed burring sufficient treatment for aneurysmal bone cysts? ( 25048282 )
2014
45
Effect of adjuvant therapies on recurrence in aneurysmal bone cysts. ( 25429574 )
2014
46
Aneurysmal bone cysts: do simple treatments work? ( 24532435 )
2014
47
Assessment of 120 maxillofacial aneurysmal bone cysts: a nationwide quest to understand this enigma. ( 24931106 )
2014
48
Destructive osteoblastoma with secondary aneurysmal bone cyst of cervical vertebra in an 11-year-old boy: case report. ( 24482719 )
2014
49
Aneurysmal bone cysts of the spine: treatment options and considerations. ( 25059450 )
2014
50
Targeting receptor-activator of nuclear kappaB ligand in aneurysmal bone cysts: verification of target and therapeutic response. ( 24726460 )
2014

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.7 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
2 plasma membrane GO:0005886 9.36 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.58 CDH11 TNFRSF11A TNFSF11
2 monocyte chemotaxis GO:0002548 9.5 CALCA TNFRSF11A TNFSF11
3 osteoclast differentiation GO:0030316 9.49 TNFRSF11A TNFSF11
4 neuron projection development GO:0031175 9.48 CDK5 MAPT
5 mammary gland alveolus development GO:0060749 9.46 TNFRSF11A TNFSF11
6 regulation of calcium-mediated signaling GO:0050848 9.43 GBP1 MAPT
7 positive regulation of neuron death GO:1901216 9.43 CDK5 GSK3B MAPT
8 TNFSF11-mediated signaling pathway GO:0071847 9.37 TNFRSF11A TNFSF11
9 sodium-independent organic anion transport GO:0043252 9.33 SLCO1A2 SLCO3A1 SLCO4A1
10 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
11 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFRSF11A TNFSF11

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Hsp90 protein binding GO:0051879 9.26 GBP1 MAPT
2 cytokine binding GO:0019955 9.16 GBP1 TNFRSF11A
3 tau-protein kinase activity GO:0050321 8.96 CDK5 GSK3B
4 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.32 SLCO3A1

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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