MCID: ANR009
MIFTS: 46

Aneurysmal Bone Cysts

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Aneurysmal Bone Cysts

MalaCards integrated aliases for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 53 37 49 28 13
Bone Cysts, Aneurysmal 69
Bone Cysts Aneurysmal 51
Aneurysmal Bone Cyst 55

Classifications:

Orphanet: 55  
Rare bone diseases


External Ids:

OMIM 53 606179
Orphanet 55 ORPHA480553
MedGen 39 C0152244
ICD10 32 M85.5
UMLS 69 C0152244

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as bone cysts, aneurysmal, is related to giant cell tumor and giant cell reparative granuloma, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and endothelial.

Wikipedia : 72 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

Description from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 giant cell tumor 30.1 CALCA TNFRSF11A TNFSF11
2 giant cell reparative granuloma 30.0 CALCA TNFRSF11A USP6
3 tooth resorption 29.6 TNFRSF11A TNFSF11
4 aneurysm 10.9
5 chondroblastoma 10.4
6 fibrous dysplasia 10.3
7 osteoblastoma 10.2
8 polyarticular onset juvenile idiopathic arthritis 10.2 TNFRSF11A TNFSF11
9 ossifying fibroma 10.2
10 breast leiomyosarcoma 10.2 TNFRSF11A TNFSF11
11 hemophilic arthropathy 10.2 TNFRSF11A TNFSF11
12 familial expansile osteolysis 10.2 TNFRSF11A TNFSF11
13 cohen-gibson syndrome 10.1 TNFRSF11A TNFSF11
14 multicentric carpotarsal osteolysis syndrome 10.1 TNFRSF11A TNFSF11
15 periapical periodontitis 10.1 TNFRSF11A TNFSF11
16 cervicitis 10.1
17 ischemic bone disease 9.9 TNFRSF11A TNFSF11
18 episodic pain syndrome, familial, 1 9.9
19 juvenile ossifying fibroma 9.9
20 chondromyxoid fibroma 9.9
21 glucocorticoid-induced osteoporosis 9.9 CALCA TNFSF11
22 paget disease of bone 5, juvenile-onset 9.9 CALCA TNFRSF11A TNFSF11
23 root resorption 9.8 CALCA TNFRSF11A TNFSF11
24 bone resorption disease 9.8 CALCA TNFRSF11A TNFSF11
25 cherubism 9.8
26 myositis 9.8
27 mccune-albright syndrome 9.8
28 chondrosarcoma 9.8
29 ameloblastoma 9.8
30 myositis ossificans 9.8
31 bone remodeling disease 9.8 CALCA TNFRSF11A TNFSF11
32 paget's disease of bone 9.8 CALCA TNFRSF11A TNFSF11
33 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.7
34 focal dermal hypoplasia 9.7
35 langerhans cell histiocytosis 9.7
36 gastrointestinal stromal tumor 9.7
37 osteofibrous dysplasia 9.7
38 glass syndrome 9.7
39 bone fracture 9.7
40 hydrocephalus 9.7
41 sinusitis 9.7
42 angiosarcoma 9.7
43 partial third-nerve palsy 9.7
44 horner's syndrome 9.7
45 secondary hyperparathyroidism of renal origin 9.7
46 hyperparathyroidism 9.7
47 obstructive hydrocephalus 9.7
48 chondroma 9.7
49 thoracic outlet syndrome 9.7
50 liposarcoma 9.7

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM:

606179

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Drugs for Aneurysmal Bone Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 1, Phase 2 615258-40-7
2 Bone Density Conservation Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
2 Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC) Recruiting NCT03066245 Phase 1, Phase 2

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

# Genetic test Affiliating Genes
1 Aneurysmal Bone Cysts 28

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

38
Bone, Endothelial, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 304)
# Title Authors Year
1
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
2018
2
Bisphosphonate therapy for spinal aneurysmal bone cysts. ( 29356986 )
2018
3
Treatment of Aneurysmal Bone Cysts with Bioactive Glass in Children. ( 28950789 )
2017
4
Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology. ( 28193096 )
2017
5
Gene fusions PAFAH1B1-USP6 and RUNX2-USP6 in aneurysmal bone cysts identified by next generation sequencing. ( 28449806 )
2017
6
Diagnosing and discriminating between primary and secondary aneurysmal bone cysts. ( 28454393 )
2017
7
Sclerotherapy using Surgiflo and alcohol: a new alternative for the treatment of aneurysmal bone cysts. ( 29263757 )
2017
8
Giant Cell Tumor of the Ribs and Aneurysmal Bone Cyst Presenting With Hemothorax in a Child. ( 28859035 )
2017
9
Secondary aneurysmal bone cyst in McCune-Albright syndrome. ( 29354163 )
2017
10
Recurrent Psammomatoid Juvenile Ossifying Fibroma with Aneurysmal Bone Cyst: An Unusual Case Presentation. ( 29184270 )
2017
11
Cervical Spine Aneurysmal Bone Cysts in the Pediatric Population: A Systematic Review of the Literature. ( 28605734 )
2017
12
Conservative management of an atypical intra-sinusal ossifying fibroma associated to an aneurysmal bone cyst. ( 29074442 )
2017
13
Treatment of aneurysmal bone cysts by percutaneous CT-guided injection of calcitonin and steroid. ( 27743037 )
2017
14
Aneurysmal bone cysts and pathologic fracture associated with supernumerary ring chromosome 6 in two unrelated patients. ( 29080333 )
2017
15
Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report. ( 27853880 )
2017
16
Aneurysmal Bone Cyst Arising from the First Rib: A Rare Cause of Thoracic Outlet Syndrome. ( 28018833 )
2016
17
Unicameral (simple) and aneurysmal bone cysts: the effect of insufficient curettage on recurrence. ( 28154666 )
2016
18
Interest of Denosumab for the Treatment of Giant-cells Tumors and Aneurysmal Bone Cysts of the Spine. About Nine Cases. ( 27244112 )
2016
19
Current management of aneurysmal bone cysts. ( 27778155 )
2016
20
Selective arterial Embolisation of Aneurysmal Bone Cysts ofA the Sacrum: a promising Alternative to Surgery. ( 26695847 )
2016
21
Craniospinal Polyostotic Fibrous Dysplasia, Aneurysmal Bone Cysts, and Chiari Type 1 Malformation Coexistence in a Patient with McCune-Albright Syndrome. ( 27161212 )
2016
22
How effective is embolization with N-2-butyl-cyanoacrylate for aneurysmal bone cysts? ( 27933423 )
2016
23
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. ( 27504302 )
2016
24
Radiotherapy for aneurysmal bone cysts : AA rare indication. ( 27957589 )
2016
25
Giant Cell Tumor with Secondary Aneurysmal Bone Cyst Shows Heterogeneous Metabolic Pattern on (18)F-FDG PET/CT: A Case Report. ( 27994691 )
2016
26
Treatment outcome in 60 children with pathological fractures of the humerus caused by juvenile or aneurysmal bone cysts. ( 29182112 )
2016
27
Conversion of Aneurysmal Bone Cyst into Fibrous Dysplasia: A Rare Pediatric Case Report. ( 27408470 )
2016
28
Giant Cell Reparative Granuloma Mimicking Aneurysmal Bone Cyst in Proximal Phalanx of Toe. ( 28435549 )
2016
29
Percutaneous Doxycycline Treatment of Juxtaphyseal Aneurysmal Bone Cysts. ( 25985367 )
2015
30
Unusual localizations of unicameral bone cysts and aneurysmal bone cysts: A retrospective review of 451 cases. ( 26280957 )
2015
31
Aneurysmal Bone Cysts of the Hand, Wrist, andA Forearm. ( 26253603 )
2015
32
Psammous desmo-osteoblastoma with concomitant aneurysmal bone cyst of mandible. ( 26389053 )
2015
33
Aneurysmal bone cyst with fibrous dysplasia resulting in partial third nerve palsy. ( 25863863 )
2015
34
Surgical treatment of active or aggressive aneurysmal bone cysts in children. ( 25812030 )
2015
35
Radiation Therapy for Aneurysmal Bone Cysts. ( 26165419 )
2015
36
Current Strategies for the Treatment of Aneurysmal Bone Cysts. ( 26793296 )
2015
37
A rare case of osteoblastoma associated to aneurysmal bone cyst of the spine. Case report. ( 26204456 )
2015
38
A case report of granular cell ameloblastoma associated with aneurysmal bone cyst like features. ( 26538973 )
2015
39
Differential diagnostic value of "blue reticulated chondroid-like material" in aneurysmal bone cysts: a classic histopathologic analysis of 215 cases. ( 25972324 )
2015
40
Destructive osteoblastoma with secondary aneurysmal bone cyst of cervical vertebra in an 11-year-old boy: case report. ( 24482719 )
2014
41
Intraspinal dural-based primary osteoblastoma with aneurysmal bone cyst-like change. ( 24984761 )
2014
42
Chondroblastoma with secondary aneurysmal bone cyst of the capitate. ( 24810829 )
2014
43
Aneurysmal bone cysts of the spine: treatment options and considerations. ( 25059450 )
2014
44
Is curettage and high-speed burring sufficient treatment for aneurysmal bone cysts? ( 25048282 )
2014
45
Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. ( 24664395 )
2014
46
USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. ( 23769422 )
2014
47
Effect of adjuvant therapies on recurrence in aneurysmal bone cysts. ( 25429574 )
2014
48
Aneurysmal bone cysts: denosumab extends its reach. ( 24837849 )
2014
49
Assessment of 120 maxillofacial aneurysmal bone cysts: a nationwide quest to understand this enigma. ( 24931106 )
2014
50
Aneurysmal bone cysts of the spine: two case reports. ( 25620988 )
2014

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.7 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
2 plasma membrane GO:0005886 9.36 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 neuron projection development GO:0031175 9.67 CDK5 GSK3B MAPT
2 ossification GO:0001503 9.58 CDH11 TNFRSF11A TNFSF11
3 cellular response to amyloid-beta GO:1904646 9.54 CDK5 GSK3B
4 osteoclast differentiation GO:0030316 9.52 TNFRSF11A TNFSF11
5 regulation of microtubule cytoskeleton organization GO:0070507 9.51 GSK3B MAPT
6 monocyte chemotaxis GO:0002548 9.5 CALCA TNFRSF11A TNFSF11
7 mammary gland alveolus development GO:0060749 9.48 TNFRSF11A TNFSF11
8 regulation of protein localization to plasma membrane GO:1903076 9.46 CDK5 GBP1
9 regulation of calcium-mediated signaling GO:0050848 9.43 GBP1 MAPT
10 positive regulation of neuron death GO:1901216 9.43 CDK5 GSK3B MAPT
11 TNFSF11-mediated signaling pathway GO:0071847 9.37 TNFRSF11A TNFSF11
12 sodium-independent organic anion transport GO:0043252 9.33 SLCO1A2 SLCO3A1 SLCO4A1
13 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
14 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFRSF11A TNFSF11

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Hsp90 protein binding GO:0051879 9.32 GBP1 MAPT
2 cytokine binding GO:0019955 9.26 GBP1 TNFRSF11A
3 tau-protein kinase activity GO:0050321 9.16 CDK5 GSK3B
4 dynactin binding GO:0034452 8.96 GSK3B MAPT
5 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.8 SLCO1A2 SLCO3A1 SLCO4A1

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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