MCID: ANG054
MIFTS: 52

Angina Pectoris malady

Cardiovascular diseases category

Summaries for Angina Pectoris

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63Wikipedia, 32MalaCards
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Wikipedia:63 Angina pectoris – commonly known as angina – is chest pain often due to ischemia of the heart... more...

MalaCards: Angina Pectoris is related to myocardial infarction and acute myocardial infarction. An important gene associated with Angina Pectoris is SERPINF2 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2), and among its related pathways are Common Pathway and Complement and coagulation cascades. The compounds fibrinopeptide a and thromboxane have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and endothelial, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Aliases & Classifications for Angina Pectoris

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32MalaCards, 30LifeMap Discovery™, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

angina pectoris 32 30


External Ids:

ICD1025 I20, I20.1

Related Diseases for Angina Pectoris

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17GeneCards, 18GeneDecks
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Diseases related to Angina Pectoris via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.5APOC3, EDN1, CRP, CHKB, AHSP, PF4
2acute myocardial infarction31.2SAA4, EDN1, CRP, CHKB, AHSP, PF4
3coronary artery disease31.2SAA4, APOC3, EDN1, CRP, CHKB, AHSP
4ischemia31.0FGA, PF4, AHSP, CHKB, EDN1
5atherosclerosis30.8AHSP, CRP, EDN1, APOC3, SAA4, PF4
6hypertension30.7EDN1, CRP
7diabetes mellitus30.7APOC3, EDN1, CRP, PF4, FGA, SERPINC1
8arteriosclerosis30.6AHSP, EDN1
9vascular disease30.5EDN1, CRP, AHSP, FGA, P2RY12, SULT1A3
10ischemic heart disease30.4EDN1, CRP, CHKB, AHSP, PF4, FGA
11coronary thrombosis30.4SERPINC1
12pneumonia30.4FGA, CRP, SAA4, CCL18
13intermediate coronary syndrome30.4SERPINC1
14intermittent claudication30.1PF4
15antiphospholipid syndrome30.1SERPINC1, SULT1A3, PF4
16obesity30.1SAA4, APOC3, NPY1R, CRP, SULT1A3
17ulcerative colitis30.1CRP
18protein c deficiency30.1SERPINC1
19amyloidosis30.1CRP, SAA4
20hypothyroidism30.1CHKB
21asthma30.1CHKB, EDN1
22dilated cardiomyopathy30.1FGA, CHKB, EDN1
23congestive heart failure30.1EDN1, CHKB, AHSP
24chronic angina10.9
25coronary stenosis10.7
26coronary restenosis10.5
27peripheral vascular disease10.4
28esophageal disease10.4
29esophagitis10.4
30spinal cord disease10.4
31cascade stomach10.3
32pernicious anemia10.3
33cervicitis10.3
34coronary arteriosclerosis10.3
35nodular goiter10.1
36subclavian steal syndrome10.1
37hereditary hemorrhagic telangiectasia10.1
38supravalvular aortic stenosis10.1
39hyperlipoproteinemia type iii10.1
40arteriovenous malformation10.1
41pharyngitis10.1
42pituitary apoplexy10.1
43dressler's syndrome10.1
44myxedema10.1
45dextrocardia10.1
46bronchiectasis10.1
47neuronitis10.1
48intestinal impaction10.1
49glucose intolerance10.1
50situs inversus10.1

Graphical network of the top 20 diseases related to Angina Pectoris:



Diseases related to angina pectoris

Clinical Features for Angina Pectoris

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Drugs & Therapeutics for Angina Pectoris

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angina Pectoris

Drug clinical trials:

Search ClinicalTrials for Angina Pectoris

Search NIH Clinical Center for Angina Pectoris

Search CenterWatch for Angina Pectoris

Genetic Tests for Angina Pectoris

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Anatomical Context for Angina Pectoris

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32MalaCards
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MalaCards organs/tissues related to Angina Pectoris:

32
Heart, Spinal cord, Endothelial, Testes, Monocytes, Brain, Whole blood, T cells, Prostate, Breast, Lung, Adipocyte, Pituitary

Animal Models for Angina Pectoris or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angina Pectoris:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4NPY1R, AHSP, PF4, FGA, P2RY12, LAG3
2MP:000537610.3CPB2, APOC3, NPY1R, EDN1, CRP, CHKB
3MP:000538710.1APOC3, NPY1R, CRP, AHSP, FGA, LAG3

Publications for Angina Pectoris

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Sources:
50PubMed
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Articles related to Angina Pectoris:

(show top 50)    (show all 698)
idTitleAuthorsYear
1
Angina pectoris: current therapy and future treatment options. (24417454)
2014
2
Early and long-term outcomes of coronary artery bypass grafting in patients with acute coronary syndrome versus stable angina pectoris. (22704288)
2013
3
Impact of ranolazine on clinical outcomes and healthcare resource utilization in patients with refractory angina pectoris. (23873327)
2013
4
The relationship between diastolic pressure and coronary collateral circulation in patients with stable angina pectoris and chronic total occlusion. (23391622)
2013
5
The Relation of Platelet-Lymphocyte Ratio and Coronary Collateral Circulation in Patients With Stable Angina Pectoris and Chronic Total Occlusion. (24142833)
2013
6
Association of air pollution and use of glyceryl trinitrate against angina pectoris: a population-based case-crossover study. (23631813)
2013
7
Predictive Value of Neutrophil to Lymphocyte Ratio in Clinical Outcomes of Non-ST Elevation Myocardial Infarction and Unstable Angina Pectoris: A 3-Year Follow-Up. (23144177)
2012
8
Are negative aspects of social relations predictive of angina pectoris? A 6-year follow-up study of middle-aged Danish women and men. (21177663)
2012
9
Effects of enhanced external counterpulsation on arterial stiffness and myocardial oxygen demand in patients with chronic angina pectoris. (21420062)
2011
10
Evidence of diminished coronary flow in pulmonary hypertension: explaining angina pectoris in this patient group? (21981460)
2011
11
Spinal cord stimulation for the treatment of refractory angina pectoris: a multicenter randomized single-blind study (the SCS-ITA trial). (21084162)
2011
12
Rate control with ivabradine: angina pectoris and beyond. (21090826)
2011
13
Evaluation of trimetazidine in angina pectoris by echocardiography and radionuclide angiography: a meta-analysis of randomized, controlled trials. (21538382)
2011
14
Circulating CD34a8_ progenitor cells and growth factors in patients treated with PCI for acute myocardial infarction or stable angina pectoris. (21463159)
2011
15
A young woman with angina pectoris: a brief report. (20097916)
2010
16
Thrombus aspiration in a series of patients with stable or unstable angina pectoris and lesion-site thrombus formation. (20862237)
2010
17
Coronary artery phenotypes in subjects with negative myocardial perfusion imaging and typical angina pectoris. (20724904)
2010
18
Effects on blood pressure in patients with refractory angina pectoris after enhanced external counterpulsation. (20429696)
2010
19
Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. (20346059)
2010
20
The conundrum of detecting stable angina pectoris in the community setting. (20027189)
2010
21
The role of emotional imagery and somatosensory amplification in atypical chest pain in patients with angina pectoris: a single-case experimental design. (19305237)
2009
22
Multiple coronary-cameral fistulae causing angina pectoris. (20069097)
2009
23
Treatment options for refractory angina pectoris: enhanced external counterpulsation therapy. (19141261)
2009
24
Comparison of prolonged bivalirudin infusion versus intraprocedural in preventing myocardial damage after percutaneous coronary intervention in patients with angina pectoris. (19801025)
2009
25
Usefulness of diabetes mellitus to predict long-term outcomes in patients with unstable angina pectoris. (19660600)
2009
26
Refractory angina pectoris carries a favourable prognosis: a three-year follow-up of 150 patients. (18609054)
2008
27
Non-compaction cardiomyopathy presenting with classical angina pectoris. (18392308)
2008
28
An unusual case of angina pectoris: a patient with isolated non-compaction of the left ventricular myocardium. (18490282)
2008
29
Failure of chronic transmyocardial laser revascularization to alter cardiac nociceptive reflexes: implications for the treatment of angina pectoris. (17546405)
2008
30
Compliance, clinical outcome, and quality of life of patients with stable angina pectoris receiving once-daily betaxolol versus twice daily metoprolol: a randomized controlled trial. (17580734)
2007
31
Changes of serum hepatocyte growth factor before and after percutaneous coronary intervention in patients with unstable angina pectoris and significance there]. (17785064)
2007
32
Gastrocardiac afferent convergence in upper thoracic spinal neurons: a central mechanism of postprandial angina pectoris. (17434802)
2007
33
Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris. (17172931)
2007
34
Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China. (17526976)
2007
35
Angina pectoris in a young athlete with anomalous coronary artery. (18232628)
2007
36
Drug-related problems in patients with angina pectoris, type 2 diabetes and asthma--interviewing patients at home. (17066246)
2006
37
Arterial remodeling correlates positively with serological evidence of inflammation in patients with chronic stable angina pectoris. (16391382)
2006
38
Successive, rapid recurrences of in-stent restenoses in a woman with angina pectoris. (17077572)
2006
39
Stent implantation, but not pathogen burden, is associated with plasma C-reactive protein and interleukin-6 levels after percutaneous coronary intervention in patients with stable angina pectoris. (15894971)
2005
40
Effect of tongxinluo capsule on function of vascular endothelium in patients with unstable angina pectoris]. (14503056)
2003
41
Levels of serum IL-1beta, IL-2, IL-8 and tumor necrosis factor-alpha in patients with unstable angina pectoris. (14668096)
2003
42
Treatment of unstable angina pectoris/non-ST-segment elevation myocardial infarction in elderly patients. (14570861)
2003
43
Plasma fibrinogen in relation to the severity of arteriosclerosis in patients with stable angina pectoris after myocardial infarction. (11352071)
2001
44
Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris. (10856385)
2000
45
Soluble antiapoptotic molecules and immune activation in chronic heart failure and unstable angina pectoris. (10821461)
2000
46
Particular fractions of microproteinuria in patients with stabile angina pectoris and without a clinical nephropathy. (11208291)
2000
47
Angina pectoris in leiomyoma]. (9757377)
1998
48
Angina pectoris and bilateral diffuse infiltrates. Lymphoplasmacytoid lymphoma. (3652760)
1987
49
Dressler's syndrome and angina pectoris relieved by surgery. (6965636)
1980
50
WEEKLY clinicopathological exercises; thyrotoxicosis and angina pectoris treated with radioactive iodine; nodular goiter, with involution; coronary occlusion, with old and recent myocardial infarction. (14780379)
1950

Genetic Variations for Angina Pectoris

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Expression for genes affiliated with Angina Pectoris

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angina Pectoris

Search GEO for disease gene expression data for Angina Pectoris.

Pathways for genes affiliated with Angina Pectoris

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 49PharmGKB
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Compounds for genes affiliated with Angina Pectoris

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Angina Pectoris according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1fibrinopeptide a4410.9PF4, FGA, SERPINC1, SERPINF2
2thromboxane44 2411.9AHSP, PF4, FGA, P2RY12, SERPINF2, EDN1
3ptca4410.9PF4, SERPINF2, FGA, SAA4, CHKB
4norepinephrine44 11 2412.9CHKB, SULT1A3, AHSP
5abciximab44 1111.9P2RY12, PF4, SERPINC1, CRP, CHKB
6aspirin44 49 28 2413.9P2RY12, FGA, PF4, CHKB, AHSP, SERPINC1
7heparin44 28 11 2413.9FGA, CPB2, P2RY12, PF4, AHSP, CHKB
86-ketoprostaglandin f1alpha4410.9EDN1, SERPINF2, FGA, PF4
9endotoxin4410.9CHKB, AHSP, FGA, SAA4
10homocysteine44 2411.9CRP, APOC3, SAA4, SULT1A3, SERPINC1, AHSP
11epinephrine44 11 2412.9FGA, P2RY12, CHKB, PF4, SERPINF2, EDN1
12tirofiban44 1111.9SERPINC1, P2RY12, PF4, CRP
13clopidogrel49 44 11 2413.9CHKB, P2RY12, SERPINC1, CRP
14fibrinogen4410.9APOC3, SULT1A3, SERPINC1, SERPINF2, CPB2, PF4
15ticlopidine44 1111.9PF4, FGA, P2RY12, SERPINC1
16prostacyclin4410.9EDN1, CRP, AHSP, FGA, PF4, SERPINC1
17cholesterol44 28 11 2413.9FGA, CPB2, SERPINF2, PTX3, PF4, SULT1A3
18thromboxane a244 2411.9PF4, AHSP, P2RY12, FGA, EDN1
19latex4410.8CHKB, PF4, CRP, SAA4, FGA
20nitroglycerin44 1111.8CHKB, AHSP, EDN1, CRP
21creatinine4410.8CHKB, EDN1, APOC3, CSNK1A1L, SAA4, CPB2
22hirudin4410.8FGA, SERPINC1, SERPINF2, PF4
23txb24410.8PF4, FGA, EDN1, SERPINF2
24ppack4410.8SERPINC1, P2RY12, FGA
25arginine4410.8CPB2, SERPINF2, SERPINC1, PF4, AHSP, CHKB
26calcium44 49 11 2413.8SERPINF2, CPB2, P2RY12, FGA, PF4, CCL18
27prostaglandin f2alpha4410.8AHSP, SAA4, CRP, EDN1
28malondialdehyde4410.8PF4, FGA, CHKB, CRP
29atp44 2811.8CHKB, NPY1R, APOC3, CSNK1A1L, AHSP, PF4
30lipid4410.8SAA4, APOC3, SERPINF2, SULT1A3, P2RY12, FGA
313-phosphoadenosine 5-phosphosulfate4410.8SERPINC1, SULT1A3, P2RY12
32nacl4410.8FGA, PF4, CHKB, SULT1A3, AHSP
33pge24410.8AHSP, PF4
34aprotinin44 1111.8PF4, FGA, SERPINC1, SERPINF2
35vegf4410.7SERPINF2, CRP, CCL18, CHKB, SERPINC1, PF4
36dopamine44 28 11 2413.7CHKB, PF4, TAF1, AHSP, SULT1A3, PTX3
37polyethylene glycol4410.7PF4, SERPINC1, CRP, CHKB
38adp44 28 2412.7CHKB, PF4, FGA, P2RY12, SERPINF2, AHSP
39nitric oxide44 11 2412.7EDN1, SULT1A3, AHSP, CHKB, APOC3, NPY1R
40alanine4410.7CCL18, CRP, CHKB, PF4, SERPINF2, TAF1
41cuprophan4410.7SERPINF2, FGA, PF4
42polysaccharide4410.7CHKB, APOC3, SERPINC1, SERPINF2, PF4
43atorvastatin44 49 28 11 2414.6EDN1, CHKB, CRP, APOC3
44polysulfone4410.6CRP, FGA, PF4
45diltiazem44 28 1112.6EDN1, SERPINC1, CHKB
46histamine44 28 2412.5FGA, AHSP, EDN1, PF4, NPY1R
47acetylcholine44 49 28 11 2414.5FGA, PF4, AHSP
48iloprost44 59 28 1113.4SERPINC1, EDN1, PF4
49citrate4410.4SERPINC1, PF4, CRP, CHKB
50rosuvastatin44 49 28 1113.2APOC3, CHKB, CRP

GO Terms for genes affiliated with Angina Pectoris

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16Gene Ontology
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Cellular components related to Angina Pectoris according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.5SERPINF2, FGA
2extracellular spaceGO:00561510.4CPB2, CCL18, APOC3, EDN1, CRP, PF4
3extracellular regionGO:00557610.3SAA4, APOC3, EDN1, CRP, PF4, FGA
4platelet alpha granule lumenGO:03109310.2SERPINF2, FGA, PF4

Biological processes related to Angina Pectoris according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759610.6CPB2, PF4, FGA, P2RY12, GP5, SERPINC1
2platelet activationGO:03016810.6SERPINF2, GP5, P2RY12, FGA, PF4
3acute-phase responseGO:00695310.6SAA4, CRP, SERPINF2
4opsonizationGO:00822810.5PTX3, CRP
5negative regulation of fibrinolysisGO:05191810.5CPB2, SERPINF2
6fibrinolysisGO:04273010.5CPB2, SERPINF2
7platelet degranulationGO:00257610.4PF4, FGA, SERPINF2
8inflammatory responseGO:00695410.1PTX3, CRP, APOC3, CCL18

Products for genes affiliated with Angina Pectoris

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angina Pectoris

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet