MCID: ANG054
MIFTS: 47

Angina Pectoris malady

Cardiovascular diseases category
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Summaries for Angina Pectoris

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Wikipedia:65 Angina pectoris ? commonly known as angina ? is chest pain often due to ischemia of the heart muscle,... more...

MalaCards based summary: Angina Pectoris is related to ischemia and myocardial infarction. An important gene associated with Angina Pectoris is SERPINF2 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds fibrinopeptide a and 6-ketoprostaglandin f1alpha have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and testes, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Angina Pectoris

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Angina Pectoris, Aliases & Descriptions:

Name: Angina Pectoris 32 30


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

ICD1025 I20, I20.1

Related Diseases for Angina Pectoris

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Diseases related to Angina Pectoris via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.0AHSP, CHKB, FGA
2myocardial infarction30.7AHSP, SERPINF2, SULT1A3, CHKB, P2RY12, CRP
3acute myocardial infarction30.6AHSP, SERPINF2, SULT1A3, CHKB, CRP, FGA
4pulmonary hypertension30.6FGA, AHSP
5amyloidosis30.5CRP
6venous thrombosis30.5SERPINF2, SULT1A3, FGA
7atherosclerosis30.3AHSP, SERPINF2, SULT1A3, P2RY12, CRP, FGA
8vascular disease30.2AHSP, SULT1A3, P2RY12, CRP, FGA
9coronary artery anomaly30.0AHSP, CHKB, CRP, FGA
10obesity30.0NPY1R, CRP, SULT1A3
11artery disease10.9
12endotheliitis10.8
13prinzmetal's variant angina10.7
14chronic angina10.7
15coronary stenosis10.6
16insulin resistance10.6
17blindness10.6
18diabetes mellitus10.5
19hypertension10.5
20arteriosclerosis10.5
21coronary arterial fistulas10.5
22peripheral vascular disease10.4
23esophageal disease10.4
24esophagitis10.4
25diverticulitis10.4ACADS
26cardiac rupture10.4CHKB
27sleep disorder10.4CHKB
28collagen disease10.3CRP
29ischemic heart disease10.3
30pernicious anemia10.3
31cascade stomach10.3
32intermediate coronary syndrome10.3
33cervicitis10.3
34pneumonia10.3
35spasticity10.3
36spinal cord infarction10.3
37pulmonary embolism10.3FGA, SERPINF2
38thrombophilia10.3SERPINF2, FGA
39coronary artery vasospasm10.3CHKB, AHSP
40stroke, ischemic10.2FGA, SULT1A3
41pre-eclampsia10.2FGA, SERPINF2, AHSP
42galactosemia10.2CHKB, SERPINF2
43asthma10.2
44congestive heart failure10.2
45dilated cardiomyopathy10.2
46hemangioma10.2
47hereditary hemorrhagic telangiectasia10.2
48hiv/aids10.2
49intermittent claudication10.2
50prostate cancer10.2

Graphical network of the top 20 diseases related to Angina Pectoris:



Diseases related to angina pectoris

Symptoms for Angina Pectoris

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Drugs & Therapeutics for Angina Pectoris

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Drug clinical trials:

Search ClinicalTrials for Angina Pectoris

Search NIH Clinical Center for Angina Pectoris

Genetic Tests for Angina Pectoris

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Anatomical Context for Angina Pectoris

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MalaCards organs/tissues related to Angina Pectoris:

32
Heart, Spinal cord, Testes, Endothelial, Monocytes, Brain, Neutrophil, Whole blood, Adipocyte, Lung, Breast, Prostate, T cells, Pituitary

Animal Models for Angina Pectoris or affiliated genes

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MGI Mouse Phenotypes related to Angina Pectoris:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.6FGA, NPY1R, CRP, ACADS, P2RY12, CHKB

Publications for Angina Pectoris

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Articles related to Angina Pectoris:

(show top 50)    (show all 716)
idTitleAuthorsYear
1
Effect of preinfarction angina pectoris on long-term survival in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention. (25159235)
2014
2
Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris. (25367628)
2014
3
Recent characteristics and outcomes of Japanese stable angina pectoris after percutaneous coronary intervention. (24309441)
2013
4
Dramatic regression of three-vessel disease under statin treatment in patients with stable angina pectoris. (23196941)
2012
5
Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study. (22231643)
2012
6
Sulfotanshinone sodium injection for unstable angina pectoris: a systematic review of randomized controlled trials. (22548119)
2012
7
Risk of angina pectoris, non-fatal myocardial infarction and non-fatal stroke among hypertensives: the CroHort study. (22338762)
2012
8
Long-term cardiovascular outcomes in patients with angina pectoris presenting with bundle branch block. (21439535)
2011
9
Changes of dendritic cells and fractalkine in type 2 diabetic patients with unstable angina pectoris: a preliminary report. (21658276)
2011
10
Effects of enhanced external counterpulsation on arterial stiffness and myocardial oxygen demand in patients with chronic angina pectoris. (21420062)
2011
11
Influence of coronary computed tomographic angiography on patient treatment and prognosis in patients with suspected stable angina pectoris. (21420047)
2011
12
Logistic regression analysis of syndrome essential factors in patients with unstable angina pectoris. (22462230)
2011
13
Recent pioneering cardiology developments in Japan: Japanese cardiologists have discovered Waon therapy for severe or refractory heart failure and extracorporeal cardiac shock wave therapy for severe angina pectoris. (21879491)
2011
14
Prevalence of angina pectoris in Pelotas, south of Brazil. (20563514)
2010
15
Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris. (20019415)
2010
16
A young woman with angina pectoris: a brief report. (20097916)
2010
17
Using biomarkers to prioritise patients with stable angina pectoris for bypass surgery. (20089597)
2010
18
Angina pectoris in consequence of subtotal subclavian artery stenosis 2 years after CABG. (20072978)
2010
19
High-dose allopurinol in patients with stable angina pectoris. (20951884)
2010
20
Thrombus aspiration in a series of patients with stable or unstable angina pectoris and lesion-site thrombus formation. (20862237)
2010
21
Angina pectoris as first manifestation of a huge biatrial myxoma. (20058514)
2009
22
Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris. (18790543)
2009
23
Circulating secretory type IIA phospholipase A2, lipoprotein (a) and soluble cellular adhesion molecule levels in patients with angina pectoris. (18848929)
2008
24
Bleeding risk and outcomes of Bivalirudin versus Glycoprotein IIb/IIIa inhibitors with targeted low-dose unfractionated Heparin in patients having percutaneous coronary intervention for either stable or unstable angina pectoris. (18602514)
2008
25
Performing stable angina pectoris: an ethnographic study. (18237834)
2008
26
Angina pectoris during daily activities and exercise stress testing: The role of inducible myocardial ischemia and psychological distress. (18694624)
2008
27
A new method to quantify coronary calcification by intravascular ultrasound - the different patterns of calcification of acute myocardial infarction, unstable angina pectoris and stable angina pectoris. (18987398)
2008
28
Myocardial infarction and angina pectoris in the history of Polish medicine. Part 2. Diagnosis and early attempts at treatment: the 19th and 20th centuries. (18575427)
2008
29
Detection of coronary microembolization by Doppler ultrasound in patients with stable angina pectoris undergoing elective percutaneous coronary interventions. (17261655)
2007
30
Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: the first placebo-controlled randomised study. (17237126)
2007
31
The editor's roundtable: chronic stable angina pectoris. (18036361)
2007
32
The development of heart failure in patients with stable angina pectoris. (17079189)
2007
33
High probability of disease in angina pectoris patients: is clinical estimation reliable? (17593989)
2007
34
Usefulness of coronary computed tomographic angiography to assess suitability for revascularization in patients with significant coronary artery disease and angina pectoris. (17056327)
2006
35
New cut-off values of cardiac markers for risk stratification of angina pectoris. (15771924)
2005
36
Effect of tongxinluo capsule on function of vascular endothelium in patients with unstable angina pectoris]. (14503056)
2003
37
The effect of a neuropeptide Y Y1 receptor antagonist in patients with angina pectoris. (12804926)
2003
38
Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)
2002
39
Perioperative management of a patient requiring surgery for pituitary apoplexy and severe angina pectoris. (11094603)
2000
40
Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group. (11015339)
2000
41
Angina pectoris in leiomyoma]. (9757377)
1998
42
A comparative study of eccentric and concentric coronary stenosis vasomotion in patients with Prinzmental's variant angina and patients with stable angina pectoris. (9755380)
1998
43
Coronary stenosis progression differs in patients with stable angina pectoris with and without a previous history of unstable angina. (8909904)
1996
44
Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS) (8682134)
1996
45
Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group. (7495059)
1995
46
The present status of treatment of unstable angina pectoris]. (8073649)
1994
47
The angiotensin-converting enzyme inhibitor in the treatment of angina pectoris]. (1568426)
1992
48
Thiol-containing agents in the management of unstable angina pectoris and acute myocardial infarction. (1928201)
1991
49
Effects of glutamate on exercise tolerance and circulating substrate levels in stable angina pectoris. (1967510)
1990
50
Congenital dextrocardia with situs inversus complicated by hypertension and angina pectoris. (15434816)
1950

Variations for Angina Pectoris

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Expression for genes affiliated with Angina Pectoris

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Expression patterns in normal tissues for genes affiliated with Angina Pectoris

Search GEO for disease gene expression data for Angina Pectoris.

Pathways for genes affiliated with Angina Pectoris

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Pathways related to Angina Pectoris according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGA, SERPINF2
29.8FGA, P2RY12
3
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)37
Fatty Acid Beta Oxidation37
9.4ACADS, CHKB
4
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.0FGA, CPB2, SERPINF2

Compounds for genes affiliated with Angina Pectoris

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 50PharmGKB
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Compounds related to Angina Pectoris according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1fibrinopeptide a4410.2SERPINF2, FGA
26-ketoprostaglandin f1alpha4410.2SERPINF2, FGA
3cuprophan4410.1SERPINF2, FGA
4ppack4410.1P2RY12, FGA
5ticlopidine44 1111.1FGA, P2RY12
6guanidino4410.0AHSP, CHKB
7hirudin4410.0FGA, SERPINF2
83-phosphoadenosine 5-phosphate4410.0SULT1A3, P2RY12
93-phosphoadenosine 5-phosphosulfate4410.0P2RY12, SULT1A3
10thromboxane a244 2410.8FGA, P2RY12, AHSP
11phosphocreatine44 2410.8P2RY12, CHKB
12convulxin449.8CRP, P2RY12
13tirofiban44 1110.8P2RY12, CRP
14polysulfone449.8FGA, CRP
15ptca449.8SERPINF2, CHKB, FGA
16txb2449.7FGA, SERPINF2
17phosphorylcholine44 2410.6CRP, CHKB
18thromboxane44 2410.6FGA, P2RY12, SERPINF2, AHSP
19histamine44 28 2411.6FGA, NPY1R, AHSP
20rosuvastatin44 50 28 1112.6CRP, CHKB
21methacholine44 50 1111.6CRP, AHSP
22prostacyclin449.5FGA, CRP, AHSP
23cerivastatin50 44 28 1112.5CHKB, CRP
24homocysteine44 2410.5CRP, SULT1A3, AHSP
25nitroglycerin44 1110.4AHSP, CHKB, CRP
26bezafibrate44 28 1111.4CRP, CHKB
27malondialdehyde449.4FGA, CRP, CHKB
28abciximab44 1110.4CRP, P2RY12, CHKB
29clopidogrel44 50 24 1112.4CRP, P2RY12, CHKB
30latex449.4CHKB, CRP, FGA
31acetylcholine44 50 28 24 1113.3AHSP, CRP, FGA
32nacl449.3AHSP, SULT1A3, CHKB, FGA
33carnitine449.2CRP, ACADS, CHKB
34nitric oxide44 24 1111.1AHSP, SULT1A3, CHKB, NPY1R
35glutamate449.0AHSP, CHKB, ACADS, CSNK1A1L
36adp44 28 2411.0AHSP, SERPINF2, CHKB, P2RY12, FGA
37potassium44 24 1111.0FGA, CHKB, AHSP
38epinephrine44 24 1110.9SERPINF2, SULT1A3, CHKB, P2RY12, FGA
39endotoxin448.8AHSP, SERPINF2, CHKB, CRP, FGA
40estrogen448.8AHSP, SULT1A3, CHKB, NPY1R
41norepinephrine44 24 1110.7AHSP, SULT1A3, CHKB, CRP, FGA
42atp44 289.6AHSP, CHKB, P2RY12, CSNK1A1L, NPY1R, FGA
43arginine448.5AHSP, SERPINF2, SULT1A3, CPB2, CHKB
44aspirin44 50 28 2411.3AHSP, SULT1A3, CHKB, P2RY12, CRP, FGA
45lipid448.0AHSP, SERPINF2, SULT1A3, P2RY12, ACADS, CRP
46heparin44 28 24 1110.8AHSP, SERPINF2, SULT1A3, CPB2, CHKB, P2RY12
47cholesterol44 28 24 1110.6AHSP, SERPINF2, SULT1A3, CPB2, CHKB, CRP
48creatinine447.5SULT1A3, CPB2, CHKB, P2RY12, CSNK1A1L, CRP
49calcium44 50 24 1110.2AHSP, SERPINF2, CPB2, CHKB, P2RY12, CRP
50fibrinogen447.2FGA, AHSP, SERPINF2, SULT1A3, CPB2, CHKB

GO Terms for genes affiliated with Angina Pectoris

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Cellular components related to Angina Pectoris according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:0055779.7FGA, SERPINF2
2platelet alpha granule lumenGO:0310939.5FGA, SERPINF2
3extracellular spaceGO:0056158.4FGA, CRP, CPB2, SERPINF2

Biological processes related to Angina Pectoris according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.6SERPINF2, CRP
2negative regulation of plasminogen activationGO:0107579.5SERPINF2, CPB2
3negative regulation of fibrinolysisGO:0519189.5SERPINF2, CPB2
4platelet activationGO:0301689.4SERPINF2, P2RY12, FGA
5fibrinolysisGO:0427309.4SERPINF2, CPB2
6protein polymerizationGO:0512589.2FGA, CRP
7blood coagulationGO:0075968.7SERPINF2, CPB2, P2RY12, FGA

Products for genes affiliated with Angina Pectoris

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Sources for Angina Pectoris

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet