MCID: ANG054
MIFTS: 46

Angina Pectoris malady

Cardiovascular diseases category
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Summaries for Angina Pectoris

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Angina pectoris ? commonly known as angina ? is chest pain often due to ischemia of the heart muscle,... more...

MalaCards: Angina Pectoris is related to myocardial infarction and coronary artery disease. An important gene associated with Angina Pectoris is SERPINF2 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds fibrinopeptide a and 6-ketoprostaglandin f1alpha have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and testes, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Angina Pectoris

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33MalaCards, 31LifeMap Discovery™, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

angina pectoris 33 31


External Ids:

ICD1025 I20, I20.1

Related Diseases for Angina Pectoris

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17GeneCards, 18GeneDecks
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Diseases related to Angina Pectoris via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.4AHSP, SERPINF2, SULT1A3, CHKB, P2RY12, CRP
2coronary artery disease31.2AHSP, CHKB, CRP, FGA
3acute myocardial infarction31.1AHSP, SERPINF2, SULT1A3, CHKB, CRP, FGA
4ischemia31.1AHSP, CHKB, FGA
5atherosclerosis30.8AHSP, SERPINF2, SULT1A3, P2RY12, CRP, FGA
6vascular disease30.5AHSP, SULT1A3, P2RY12, CRP, FGA
7amyloidosis30.3CRP
8venous thrombosis30.3SERPINF2, SULT1A3, FGA
9obesity30.2NPY1R, CRP, SULT1A3
10artery disease10.9
11endotheliitis10.7
12prinzmetal's variant angina10.7
13chronic angina10.7
14coronary stenosis10.6
15insulin resistance10.6
16blindness10.6
17diabetes mellitus10.5
18hypertension10.5
19arteriosclerosis10.5
20coronary arterial fistulas10.5
21peripheral vascular disease10.4
22esophageal disease10.4
23esophagitis10.4
24intermediate coronary syndrome10.3
25cascade stomach10.3
26pernicious anemia10.3
27cervicitis10.3
28pneumonia10.3
29spinal cord infarction10.3
30supravalvular aortic stenosis10.2
31antiphospholipid syndrome10.2
32hereditary hemorrhagic telangiectasia10.2
33pituitary apoplexy10.2
34pharyngitis10.2
35dextrocardia10.2
36bronchiectasis10.2
37neuronitis10.2
38dressler's syndrome10.2
39myxedema10.2
40glucose intolerance10.2
41coronary thrombosis10.2
42situs inversus10.2
43coronary restenosis10.2
44systolic heart failure10.2
45ulcerative colitis10.2
46hypertrophic cardiomyopathy10.2
47familial hypertrophic cardiomyopathy10.2
48common cold10.2
49postcholecystectomy syndrome10.2
50mucinous adenocarcinoma10.2

Graphical network of the top 20 diseases related to Angina Pectoris:



Diseases related to angina pectoris

Symptoms for Angina Pectoris

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Drugs & Therapeutics for Angina Pectoris

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Angina Pectoris

Search NIH Clinical Center for Angina Pectoris

Genetic Tests for Angina Pectoris

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Anatomical Context for Angina Pectoris

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33MalaCards
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MalaCards organs/tissues related to Angina Pectoris:

33
Heart, Spinal cord, Testes, Endothelial, Monocytes, Brain, Pituitary, T cells, Breast, Whole blood, Lung, Adipocyte

Animal Models for Angina Pectoris or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Angina Pectoris:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.6FGA, NPY1R, CRP, ACADS, P2RY12, CHKB

Publications for Angina Pectoris

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52PubMed
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Articles related to Angina Pectoris:

(show top 50)    (show all 691)
idTitleAuthorsYear
1
Recent characteristics and outcomes of Japanese stable angina pectoris after percutaneous coronary intervention. (24309441)
2013
2
Dramatic regression of three-vessel disease under statin treatment in patients with stable angina pectoris. (23196941)
2012
3
Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study. (22231643)
2012
4
Sulfotanshinone sodium injection for unstable angina pectoris: a systematic review of randomized controlled trials. (22548119)
2012
5
Risk of angina pectoris, non-fatal myocardial infarction and non-fatal stroke among hypertensives: the CroHort study. (22338762)
2012
6
Long-term cardiovascular outcomes in patients with angina pectoris presenting with bundle branch block. (21439535)
2011
7
Changes of dendritic cells and fractalkine in type 2 diabetic patients with unstable angina pectoris: a preliminary report. (21658276)
2011
8
Effects of enhanced external counterpulsation on arterial stiffness and myocardial oxygen demand in patients with chronic angina pectoris. (21420062)
2011
9
Influence of coronary computed tomographic angiography on patient treatment and prognosis in patients with suspected stable angina pectoris. (21420047)
2011
10
Logistic regression analysis of syndrome essential factors in patients with unstable angina pectoris. (22462230)
2011
11
Recent pioneering cardiology developments in Japan: Japanese cardiologists have discovered Waon therapy for severe or refractory heart failure and extracorporeal cardiac shock wave therapy for severe angina pectoris. (21879491)
2011
12
Prevalence of angina pectoris in Pelotas, south of Brazil. (20563514)
2010
13
Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris. (20019415)
2010
14
A young woman with angina pectoris: a brief report. (20097916)
2010
15
Using biomarkers to prioritise patients with stable angina pectoris for bypass surgery. (20089597)
2010
16
Angina pectoris in consequence of subtotal subclavian artery stenosis 2 years after CABG. (20072978)
2010
17
High-dose allopurinol in patients with stable angina pectoris. (20951884)
2010
18
Thrombus aspiration in a series of patients with stable or unstable angina pectoris and lesion-site thrombus formation. (20862237)
2010
19
Angina pectoris as first manifestation of a huge biatrial myxoma. (20058514)
2009
20
Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris. (18790543)
2009
21
Circulating secretory type IIA phospholipase A2, lipoprotein (a) and soluble cellular adhesion molecule levels in patients with angina pectoris. (18848929)
2008
22
Bleeding risk and outcomes of Bivalirudin versus Glycoprotein IIb/IIIa inhibitors with targeted low-dose unfractionated Heparin in patients having percutaneous coronary intervention for either stable or unstable angina pectoris. (18602514)
2008
23
Performing stable angina pectoris: an ethnographic study. (18237834)
2008
24
Angina pectoris during daily activities and exercise stress testing: The role of inducible myocardial ischemia and psychological distress. (18694624)
2008
25
A new method to quantify coronary calcification by intravascular ultrasound - the different patterns of calcification of acute myocardial infarction, unstable angina pectoris and stable angina pectoris. (18987398)
2008
26
Myocardial infarction and angina pectoris in the history of Polish medicine. Part 2. Diagnosis and early attempts at treatment: the 19th and 20th centuries. (18575427)
2008
27
Compliance, clinical outcome, and quality of life of patients with stable angina pectoris receiving once-daily betaxolol versus twice daily metoprolol: a randomized controlled trial. (17580734)
2007
28
Detection of coronary microembolization by Doppler ultrasound in patients with stable angina pectoris undergoing elective percutaneous coronary interventions. (17261655)
2007
29
Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: the first placebo-controlled randomised study. (17237126)
2007
30
The editor's roundtable: chronic stable angina pectoris. (18036361)
2007
31
The development of heart failure in patients with stable angina pectoris. (17079189)
2007
32
High probability of disease in angina pectoris patients: is clinical estimation reliable? (17593989)
2007
33
Usefulness of coronary computed tomographic angiography to assess suitability for revascularization in patients with significant coronary artery disease and angina pectoris. (17056327)
2006
34
New cut-off values of cardiac markers for risk stratification of angina pectoris. (15771924)
2005
35
Effect of tongxinluo capsule on function of vascular endothelium in patients with unstable angina pectoris]. (14503056)
2003
36
The effect of a neuropeptide Y Y1 receptor antagonist in patients with angina pectoris. (12804926)
2003
37
Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)
2002
38
Perioperative management of a patient requiring surgery for pituitary apoplexy and severe angina pectoris. (11094603)
2000
39
Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group. (11015339)
2000
40
Angina pectoris in leiomyoma]. (9757377)
1998
41
A comparative study of eccentric and concentric coronary stenosis vasomotion in patients with Prinzmental's variant angina and patients with stable angina pectoris. (9755380)
1998
42
Coronary stenosis progression differs in patients with stable angina pectoris with and without a previous history of unstable angina. (8909904)
1996
43
Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS) (8682134)
1996
44
Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group. (7495059)
1995
45
The present status of treatment of unstable angina pectoris]. (8073649)
1994
46
The angiotensin-converting enzyme inhibitor in the treatment of angina pectoris]. (1568426)
1992
47
Thiol-containing agents in the management of unstable angina pectoris and acute myocardial infarction. (1928201)
1991
48
Effects of glutamate on exercise tolerance and circulating substrate levels in stable angina pectoris. (1967510)
1990
49
Continuous electrocardiographic recording in Prinzmetal's variant angina pectoris. A report of four cases. (5470041)
1970
50
Congenital dextrocardia with situs inversus complicated by hypertension and angina pectoris. (15434816)
1950

Variations for Angina Pectoris

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Expression for genes affiliated with Angina Pectoris

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angina Pectoris

Search GEO for disease gene expression data for Angina Pectoris.

Pathways for genes affiliated with Angina Pectoris

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 54R&D Systems, 51PharmGKB, 30KEGG
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Pathways related to Angina Pectoris according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGA, SERPINF2
29.8FGA, P2RY12
3
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)38
Fatty Acid Beta Oxidation38
9.4ACADS, CHKB
4
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.0FGA, CPB2, SERPINF2

Compounds for genes affiliated with Angina Pectoris

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 51PharmGKB
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Compounds related to Angina Pectoris according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1fibrinopeptide a4510.2SERPINF2, FGA
26-ketoprostaglandin f1alpha4510.2SERPINF2, FGA
3cuprophan4510.1SERPINF2, FGA
4ppack4510.1P2RY12, FGA
5ticlopidine45 1111.1FGA, P2RY12
6guanidino4510.0AHSP, CHKB
7hirudin4510.0FGA, SERPINF2
83-phosphoadenosine 5-phosphate4510.0SULT1A3, P2RY12
93-phosphoadenosine 5-phosphosulfate4510.0P2RY12, SULT1A3
10thromboxane a245 2410.8FGA, P2RY12, AHSP
11phosphocreatine45 2410.8P2RY12, CHKB
12convulxin459.8CRP, P2RY12
13tirofiban45 1110.8P2RY12, CRP
14polysulfone459.8FGA, CRP
15ptca459.8SERPINF2, CHKB, FGA
16txb2459.7FGA, SERPINF2
17phosphorylcholine45 2410.6CRP, CHKB
18thromboxane45 2410.6FGA, P2RY12, SERPINF2, AHSP
19histamine45 29 2411.6FGA, NPY1R, AHSP
20rosuvastatin45 51 29 1112.6CRP, CHKB
21methacholine45 51 1111.6CRP, AHSP
22prostacyclin459.5FGA, CRP, AHSP
23cerivastatin51 45 29 1112.5CHKB, CRP
24homocysteine45 2410.5CRP, SULT1A3, AHSP
25nitroglycerin45 1110.4AHSP, CHKB, CRP
26bezafibrate45 29 1111.4CRP, CHKB
27malondialdehyde459.4FGA, CRP, CHKB
28abciximab45 1110.4CRP, P2RY12, CHKB
29clopidogrel45 51 24 1112.4CRP, P2RY12, CHKB
30latex459.4CHKB, CRP, FGA
31acetylcholine45 51 29 24 1113.3AHSP, CRP, FGA
32nacl459.3AHSP, SULT1A3, CHKB, FGA
33carnitine459.2CRP, ACADS, CHKB
34nitric oxide45 24 1111.1AHSP, SULT1A3, CHKB, NPY1R
35glutamate459.0AHSP, CHKB, ACADS, CSNK1A1L
36adp45 29 2411.0AHSP, SERPINF2, CHKB, P2RY12, FGA
37potassium45 24 1111.0FGA, CHKB, AHSP
38epinephrine45 24 1110.9SERPINF2, SULT1A3, CHKB, P2RY12, FGA
39endotoxin458.8AHSP, SERPINF2, CHKB, CRP, FGA
40estrogen458.8AHSP, SULT1A3, CHKB, NPY1R
41norepinephrine45 24 1110.7AHSP, SULT1A3, CHKB, CRP, FGA
42atp45 299.6AHSP, CHKB, P2RY12, CSNK1A1L, NPY1R, FGA
43arginine458.5AHSP, SERPINF2, SULT1A3, CPB2, CHKB
44aspirin45 51 29 2411.3AHSP, SULT1A3, CHKB, P2RY12, CRP, FGA
45lipid458.0AHSP, SERPINF2, SULT1A3, P2RY12, ACADS, CRP
46heparin45 29 24 1110.8AHSP, SERPINF2, SULT1A3, CPB2, CHKB, P2RY12
47cholesterol45 29 24 1110.6AHSP, SERPINF2, SULT1A3, CPB2, CHKB, CRP
48creatinine457.5SULT1A3, CPB2, CHKB, P2RY12, CSNK1A1L, CRP
49calcium45 51 24 1110.2AHSP, SERPINF2, CPB2, CHKB, P2RY12, CRP
50fibrinogen457.2FGA, AHSP, SERPINF2, SULT1A3, CPB2, CHKB

GO Terms for genes affiliated with Angina Pectoris

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16Gene Ontology
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Cellular components related to Angina Pectoris according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:0055779.7FGA, SERPINF2
2platelet alpha granule lumenGO:0310939.5FGA, SERPINF2
3extracellular spaceGO:0056158.4FGA, CRP, CPB2, SERPINF2

Biological processes related to Angina Pectoris according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.6CRP, SERPINF2
2negative regulation of plasminogen activationGO:0107579.5CPB2, SERPINF2
3negative regulation of fibrinolysisGO:0519189.5CPB2, SERPINF2
4platelet activationGO:0301689.4FGA, P2RY12, SERPINF2
5fibrinolysisGO:0427309.4SERPINF2, CPB2
6protein polymerizationGO:0512589.2FGA, CRP
7blood coagulationGO:0075968.7FGA, P2RY12, CPB2, SERPINF2

Products for genes affiliated with Angina Pectoris

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Sources for Angina Pectoris

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet