MCID: ANG054
MIFTS: 52

Angina Pectoris malady

Cardiovascular diseases category

Summaries for Angina Pectoris

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63Wikipedia, 32MalaCards
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Wikipedia:63 Angina pectoris – commonly known as angina – is chest pain often due to ischemia of the heart... more...

MalaCards: Angina Pectoris is related to myocardial infarction and acute myocardial infarction. An important gene associated with Angina Pectoris is SERPINF2 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2), and among its related pathways are Common Pathway and Complement and coagulation cascades. The compounds fibrinopeptide a and thromboxane have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and testes, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Aliases & Classifications for Angina Pectoris

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32MalaCards, 30LifeMap Discovery™, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

angina pectoris 32 30


External Ids:

ICD1025 I20, I20.1

Related Diseases for Angina Pectoris

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17GeneCards, 18GeneDecks
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Diseases related to Angina Pectoris via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.5APOC3, EDN1, CRP, CHKB, AHSP, PF4
2acute myocardial infarction31.2SAA4, EDN1, CRP, CHKB, AHSP, PF4
3coronary artery disease31.2SAA4, APOC3, EDN1, CRP, CHKB, AHSP
4ischemia31.0FGA, PF4, AHSP, CHKB, EDN1
5atherosclerosis30.8AHSP, CRP, EDN1, APOC3, SAA4, PF4
6hypertension30.7EDN1, CRP
7diabetes mellitus30.7APOC3, EDN1, CRP, PF4, FGA, SERPINC1
8arteriosclerosis30.6AHSP, EDN1
9vascular disease30.5EDN1, CRP, AHSP, FGA, P2RY12, SULT1A3
10ischemic heart disease30.4EDN1, CRP, CHKB, AHSP, PF4, FGA
11coronary thrombosis30.4SERPINC1
12pneumonia30.4FGA, CRP, SAA4, CCL18
13intermediate coronary syndrome30.4SERPINC1
14intermittent claudication30.1PF4
15antiphospholipid syndrome30.1SERPINC1, SULT1A3, PF4
16obesity30.1SAA4, APOC3, NPY1R, CRP, SULT1A3
17ulcerative colitis30.1CRP
18protein c deficiency30.1SERPINC1
19amyloidosis30.1CRP, SAA4
20hypothyroidism30.1CHKB
21asthma30.1CHKB, EDN1
22dilated cardiomyopathy30.1FGA, CHKB, EDN1
23congestive heart failure30.1EDN1, CHKB, AHSP
24chronic angina10.9
25coronary stenosis10.7
26coronary restenosis10.5
27peripheral vascular disease10.4
28esophageal disease10.4
29esophagitis10.4
30spinal cord disease10.4
31cascade stomach10.3
32pernicious anemia10.3
33cervicitis10.3
34coronary arteriosclerosis10.3
35nodular goiter10.1
36subclavian steal syndrome10.1
37hereditary hemorrhagic telangiectasia10.1
38supravalvular aortic stenosis10.1
39hyperlipoproteinemia type iii10.1
40arteriovenous malformation10.1
41pharyngitis10.1
42pituitary apoplexy10.1
43dressler's syndrome10.1
44myxedema10.1
45dextrocardia10.1
46bronchiectasis10.1
47neuronitis10.1
48intestinal impaction10.1
49glucose intolerance10.1
50situs inversus10.1

Graphical network of the top 20 diseases related to Angina Pectoris:



Diseases related to angina pectoris

Clinical Features for Angina Pectoris

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Drugs & Therapeutics for Angina Pectoris

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angina Pectoris

Drug clinical trials:

Search ClinicalTrials for Angina Pectoris

Search NIH Clinical Center for Angina Pectoris

Search CenterWatch for Angina Pectoris

Genetic Tests for Angina Pectoris

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Anatomical Context for Angina Pectoris

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32MalaCards
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MalaCards organs/tissues related to Angina Pectoris:

32
Heart, Spinal cord, Testes, Endothelial, Monocytes, Brain, Pituitary, T cells, Breast, Adipocyte, Whole blood, Lung, Prostate

Animal Models for Angina Pectoris or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angina Pectoris:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4NPY1R, AHSP, PF4, FGA, P2RY12, LAG3
2MP:000537610.3CPB2, APOC3, NPY1R, EDN1, CRP, CHKB
3MP:000538710.1APOC3, NPY1R, CRP, AHSP, FGA, LAG3

Publications for Angina Pectoris

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50PubMed
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Articles related to Angina Pectoris:

(show top 50)    (show all 698)
idTitleAuthorsYear
1
Recent characteristics and outcomes of Japanese stable angina pectoris after percutaneous coronary intervention. (24309441)
2013
2
Heart Failure with Preserved Ejection Fraction: Comparison of Patients With and Without Angina Pectoris (From the Duke Databank for Cardiovascular Disease). (24161322)
2013
3
Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris. (23641832)
2013
4
Relationship between myocardial bridges and reduced coronary atherosclerosis in patients with angina pectoris. (22386701)
2013
5
Double-Blind Parallel Placebo-Controlled Study to Evaluate the Effect of Molsidomine on the Endothelial Dysfunction in Patients with Stable Angina Pectoris Undergoing Percutaneous Coronary Intervention: the MEDCOR Trial. (24142804)
2013
6
Risk of angina pectoris, non-fatal myocardial infarction and non-fatal stroke among hypertensives: the CroHort study. (22338762)
2012
7
Some thoughts on the continuing dilemma of angina pectoris. (23045268)
2012
8
High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries. The ACOVA Study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries). (22322081)
2012
9
Tissue Doppler echocardiography improves the diagnosis of coronary artery stenosis in stable angina pectoris. (22323549)
2012
10
Effect of embolic particles during coronary interventional procedures on regional wall motion in patients with stable angina pectoris. (22245408)
2012
11
Can metabolic syndrome predict the vulnerable plaque in patients with stable angina pectoris? Virtual histology-intravascular ultrasound analysis. (22341056)
2012
12
Recent pioneering cardiology developments in Japan: Japanese cardiologists have discovered Waon therapy for severe or refractory heart failure and extracorporeal cardiac shock wave therapy for severe angina pectoris. (21879491)
2011
13
Reduced peripheral vascular reactivity in refractory angina pectoris: Effect of enhanced external counterpulsation. (22783308)
2011
14
Neurostimulation therapy for refractory angina pectoris. (21441792)
2011
15
Coronary anomaly and coronary artery fistula as cause of angina pectoris with literature review. (22937462)
2011
16
Percutaneous coronary intervention with optimal medical therapy vs. optimal medical therapy alone for patients with stable angina pectoris. (22205918)
2011
17
Ivabradine for the treatment of stable angina pectoris in octogenarians. (20821016)
2011
18
Functional effect of platelet membrane glycoprotein ia gene polymorphism in the pathogenesis of unstable angina pectoris. (21672359)
2011
19
Vascular endothelial function and carotid intima-media thickness in patients with isolated coronary artery ectasia and exercise-induced angina pectoris. (20550975)
2010
20
Coronary-cameral fistula with angina pectoris. (21209744)
2010
21
Gender specific variations in the description, intensity and location of angina pectoris: a cross-sectional study. (20138276)
2010
22
Long-term results (three-year) of emergency coronary artery bypass grafting for patients with unstable angina pectoris. (20691309)
2010
23
Clinical effect and mechanismn of xuefu zhuyu capsule in treating unstable angina pectoris]. (19338157)
2009
24
Effect of drug-eluting stents on frequency of repeat revascularization in patients with unstable angina pectoris or non-ST-elevation myocardial infarction. (19962470)
2009
25
Effect of buxu huayu qutan decoction on anti-oxidative capacity in aged patients with stable angina pectoris of coronary heart disease]. (19848199)
2009
26
Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study. (19629011)
2009
27
Efficacy of I(f) inhibition with ivabradine in different subpopulations with stable angina pectoris. (19468225)
2009
28
Heart rate variability analysis at coronary artery disease and angina pectoris. (19149706)
2009
29
Frequency of electrocardiographic recordings in patients presenting with angina pectoris (from the Investigation of National Coronary Disease Identification). (19166681)
2009
30
Neopterin for risk assessment in angina pectoris. (19536366)
2009
31
Angina pectoris during daily activities and exercise stress testing: The role of inducible myocardial ischemia and psychological distress. (18694624)
2008
32
Prognostic value of circulating pregnancy-associated plasma protein-A (PAPP-A) and proform of eosinophil major basic protein (pro-MBP) levels in patients with chronic stable angina pectoris. (18267116)
2008
33
Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation. (18342222)
2008
34
Clinical and cost-effectiveness analysis of an open label, single-centre, randomised trial of spinal cord stimulation (SCS) versus percutaneous myocardial laser revascularisation (PMR) in patients with refractory angina pectoris: The SPiRiT trial. (18590536)
2008
35
Appropriateness of diagnosis of unstable angina pectoris in patients referred for coronary arteriography. (19343128)
2008
36
Angina pectoris: reversal of the gender gap. (18362242)
2008
37
Spinal cord stimulation for refractory chronic angina pectoris: influence on quality of life. (20528416)
2007
38
Serial intravascular ultrasonic study of outcomes of coronary culprit lesions with plaque rupture following bare metal stent implantation in patients with angina pectoris. (17493467)
2007
39
Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris. (16565555)
2006
40
Disease activities and serum C-reactive protein levels in patients with vasospastic angina pectoris]. (16127895)
2005
41
Usefulness of brain natriuretic peptide levels to discriminate patients with stable angina pectoris without and with electrocardiographic myocardial ischemia and patients with healed myocardial infarction. (15374788)
2004
42
Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)
2002
43
Plasma endothelin-1 levels in patients with angina pectoris and normal coronary angiograms. (9539486)
1998
44
Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group. (7495059)
1995
45
Activation of the hemostatic mechanism during thrombolysis in patients with unstable angina pectoris. (7579435)
1995
46
Cardiolipin antibodies in patients with myocardial infarction and unstable angina pectoris]. (1405256)
1992
47
Captopril in the therapy of stable angina pectoris]. (2184938)
1990
48
Angina pectoris at rest with preservation of exercise capacity: Prinzmetal's variant angina. (4705584)
1973
49
Left ventricular performance and related haemodynamic changes in Prinzmetal's variant angina pectoris. (5541922)
1971
50
Studies on angina pectoris and postural hypotension. (4241314)
1969

Genetic Variations for Angina Pectoris

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Expression for genes affiliated with Angina Pectoris

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angina Pectoris

Search GEO for disease gene expression data for Angina Pectoris.

Pathways for genes affiliated with Angina Pectoris

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 49PharmGKB
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Compounds for genes affiliated with Angina Pectoris

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Angina Pectoris according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1fibrinopeptide a4410.9PF4, FGA, SERPINC1, SERPINF2
2thromboxane44 2411.9EDN1, AHSP, PF4, FGA, P2RY12, SERPINF2
3ptca4410.9SAA4, CHKB, PF4, FGA, SERPINF2
4norepinephrine44 11 2412.9CHKB, AHSP, SULT1A3
5abciximab44 1111.9CRP, CHKB, PF4, P2RY12, SERPINC1
6aspirin44 49 28 2413.9CRP, CHKB, AHSP, PF4, FGA, P2RY12
7heparin44 28 11 2413.9APOC3, CHKB, AHSP, PF4, FGA, P2RY12
86-ketoprostaglandin f1alpha4410.9SERPINF2, FGA, PF4, EDN1
9endotoxin4410.9SAA4, CHKB, AHSP, FGA
10homocysteine44 2411.9SAA4, APOC3, CRP, AHSP, SULT1A3, SERPINC1
11epinephrine44 11 2412.9EDN1, CHKB, PF4, FGA, P2RY12, SULT1A3
12tirofiban44 1111.9SERPINC1, P2RY12, PF4, CRP
13clopidogrel49 44 11 2413.9CRP, CHKB, P2RY12, SERPINC1
14ticlopidine44 1111.9PF4, FGA, P2RY12, SERPINC1
15prostacyclin4410.9EDN1, CRP, AHSP, PF4, FGA, SERPINC1
16fibrinogen4410.9SERPINC1, SULT1A3, GP5, P2RY12, FGA, PF4
17cholesterol44 28 11 2413.9SAA4, APOC3, CRP, CHKB, AHSP, PF4
18thromboxane a244 2411.9EDN1, AHSP, PF4, FGA, P2RY12
19latex4410.8SAA4, CRP, CHKB, PF4, FGA
20nitroglycerin44 1111.8EDN1, CRP, CHKB, AHSP
21creatinine4410.8CPB2, SAA4, SERPINC1, PTX3, SULT1A3, P2RY12
22hirudin4410.8PF4, FGA, SERPINC1, SERPINF2
23txb24410.8EDN1, PF4, FGA, SERPINF2
24ppack4410.8SERPINC1, P2RY12, FGA
25arginine4410.8EDN1, CHKB, AHSP, PF4, SULT1A3, SERPINC1
26calcium44 49 11 2413.8CCL18, SAA4, NPY1R, EDN1, CRP, CHKB
27prostaglandin f2alpha4410.8SAA4, EDN1, CRP, AHSP
28malondialdehyde4410.8FGA, PF4, CHKB, CRP
29atp44 2811.8CSNK1A1L, APOC3, NPY1R, CHKB, AHSP, PF4
30lipid4410.8SAA4, APOC3, CRP, AHSP, PF4, FGA
313-phosphoadenosine 5-phosphosulfate4410.8SERPINC1, SULT1A3, P2RY12
32nacl4410.8CHKB, AHSP, PF4, FGA, SULT1A3
33pge24410.8AHSP, PF4
34aprotinin44 1111.8SERPINF2, SERPINC1, FGA, PF4
35vegf4410.7CCL18, EDN1, CRP, CHKB, PF4, SERPINC1
36dopamine44 28 11 2413.7CHKB, AHSP, PF4, TAF1, SULT1A3, PTX3
37polyethylene glycol4410.7CRP, CHKB, PF4, SERPINC1
38adp44 28 2412.7CHKB, AHSP, PF4, FGA, P2RY12, SERPINF2
39nitric oxide44 11 2412.7APOC3, NPY1R, EDN1, CHKB, AHSP, SULT1A3
40alanine4410.7CCL18, CRP, CHKB, PF4, TAF1, SERPINC1
41cuprophan4410.7PF4, FGA, SERPINF2
42polysaccharide4410.7SERPINF2, SERPINC1, PF4, CHKB, APOC3
43atorvastatin44 49 28 11 2414.6APOC3, EDN1, CRP, CHKB
44diltiazem44 28 1112.6EDN1, CHKB, SERPINC1
45polysulfone4410.6CRP, PF4, FGA
46histamine44 28 2412.5NPY1R, EDN1, AHSP, PF4, FGA
47acetylcholine44 49 28 11 2414.5FGA, PF4, AHSP
48iloprost44 59 28 1113.4SERPINC1, PF4, EDN1
49citrate4410.4CRP, CHKB, PF4, SERPINC1
50rosuvastatin44 49 28 1113.2CHKB, CRP, APOC3

GO Terms for genes affiliated with Angina Pectoris

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16Gene Ontology
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Cellular components related to Angina Pectoris according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.5SERPINF2, FGA
2extracellular spaceGO:00561510.4CPB2, CCL18, APOC3, EDN1, CRP, PF4
3extracellular regionGO:00557610.3SAA4, APOC3, EDN1, CRP, PF4, FGA
4platelet alpha granule lumenGO:03109310.2SERPINF2, FGA, PF4

Biological processes related to Angina Pectoris according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759610.6CPB2, PF4, FGA, P2RY12, GP5, SERPINC1
2platelet activationGO:03016810.6SERPINF2, GP5, P2RY12, FGA, PF4
3acute-phase responseGO:00695310.6SAA4, CRP, SERPINF2
4opsonizationGO:00822810.5PTX3, CRP
5negative regulation of fibrinolysisGO:05191810.5CPB2, SERPINF2
6fibrinolysisGO:04273010.5CPB2, SERPINF2
7platelet degranulationGO:00257610.4PF4, FGA, SERPINF2
8inflammatory responseGO:00695410.1PTX3, CRP, APOC3, CCL18

Products for genes affiliated with Angina Pectoris

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angina Pectoris

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet