MCID: ANG054
MIFTS: 52

Angina Pectoris malady

Cardiovascular diseases category

Summaries for Angina Pectoris

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63Wikipedia, 32MalaCards
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Wikipedia:63 Angina pectoris – commonly known as angina – is chest pain often due to ischemia of the heart... more...

MalaCards: Angina Pectoris is related to myocardial infarction and acute myocardial infarction. An important gene associated with Angina Pectoris is SERPINF2 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2), and among its related pathways are Common Pathway and Complement and coagulation cascades. The compounds fibrinopeptide a and thromboxane have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and endothelial, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Aliases & Classifications for Angina Pectoris

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32MalaCards, 30LifeMap Discovery™, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

angina pectoris 32 30


External Ids:

ICD1025 I20, I20.1

Related Diseases for Angina Pectoris

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17GeneCards, 18GeneDecks
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Diseases related to Angina Pectoris via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.5APOC3, EDN1, CRP, CHKB, AHSP, PF4
2acute myocardial infarction31.2SAA4, EDN1, CRP, CHKB, AHSP, PF4
3coronary artery disease31.2SAA4, APOC3, EDN1, CRP, CHKB, AHSP
4ischemia31.0FGA, PF4, AHSP, CHKB, EDN1
5atherosclerosis30.8AHSP, CRP, EDN1, APOC3, SAA4, PF4
6hypertension30.7EDN1, CRP
7diabetes mellitus30.7APOC3, EDN1, CRP, PF4, FGA, SERPINC1
8arteriosclerosis30.6AHSP, EDN1
9vascular disease30.5EDN1, CRP, AHSP, FGA, P2RY12, SULT1A3
10ischemic heart disease30.4EDN1, CRP, CHKB, AHSP, PF4, FGA
11coronary thrombosis30.4SERPINC1
12pneumonia30.4FGA, CRP, SAA4, CCL18
13intermediate coronary syndrome30.4SERPINC1
14intermittent claudication30.1PF4
15antiphospholipid syndrome30.1SERPINC1, SULT1A3, PF4
16obesity30.1SAA4, APOC3, NPY1R, CRP, SULT1A3
17ulcerative colitis30.1CRP
18protein c deficiency30.1SERPINC1
19amyloidosis30.1CRP, SAA4
20hypothyroidism30.1CHKB
21asthma30.1CHKB, EDN1
22dilated cardiomyopathy30.1FGA, CHKB, EDN1
23congestive heart failure30.1EDN1, CHKB, AHSP
24chronic angina10.9
25coronary stenosis10.7
26coronary restenosis10.5
27peripheral vascular disease10.4
28esophageal disease10.4
29esophagitis10.4
30spinal cord disease10.4
31cascade stomach10.3
32pernicious anemia10.3
33cervicitis10.3
34coronary arteriosclerosis10.3
35nodular goiter10.1
36subclavian steal syndrome10.1
37hereditary hemorrhagic telangiectasia10.1
38supravalvular aortic stenosis10.1
39hyperlipoproteinemia type iii10.1
40arteriovenous malformation10.1
41pharyngitis10.1
42pituitary apoplexy10.1
43dressler's syndrome10.1
44myxedema10.1
45dextrocardia10.1
46bronchiectasis10.1
47neuronitis10.1
48intestinal impaction10.1
49glucose intolerance10.1
50situs inversus10.1

Graphical network of the top 20 diseases related to Angina Pectoris:



Diseases related to angina pectoris

Clinical Features for Angina Pectoris

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Drugs & Therapeutics for Angina Pectoris

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angina Pectoris

Drug clinical trials:

Search ClinicalTrials for Angina Pectoris

Search NIH Clinical Center for Angina Pectoris

Search CenterWatch for Angina Pectoris

Genetic Tests for Angina Pectoris

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Anatomical Context for Angina Pectoris

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32MalaCards
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MalaCards organs/tissues related to Angina Pectoris:

32
Heart, Spinal cord, Endothelial, Testes, Monocytes, Brain, Whole blood, T cells, Prostate, Breast, Lung, Adipocyte, Pituitary

Animal Models for Angina Pectoris or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angina Pectoris:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4NPY1R, AHSP, PF4, FGA, P2RY12, LAG3
2MP:000537610.3CPB2, APOC3, NPY1R, EDN1, CRP, CHKB
3MP:000538710.1APOC3, NPY1R, CRP, AHSP, FGA, LAG3

Publications for Angina Pectoris

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50PubMed
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Articles related to Angina Pectoris:

(show top 50)    (show all 698)
idTitleAuthorsYear
1
Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients. (24031042)
2013
2
Clinical outcomes of low-dose aspirin administration in patients with variant angina pectoris. (23182000)
2013
3
Effect of folic acid supplementation on levels of circulating Monocyte Chemoattractant Protein-1 and the presence of intravascular ultrasound derived virtual histology thin-cap fibroatheromas in patients with stable angina pectoris. (23936148)
2013
4
Angina pectoris: First manifestation of a left atrial myxoma. (24411919)
2013
5
Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris. (22433902)
2012
6
Angina pectoris in patients with normal coronary angiograms: current pathophysiological concepts and therapeutic options. (22668869)
2012
7
Angina pectoris with troponin increase in arrhythmogenic right ventricle dysplasia: case article and review of the literature. (22290592)
2012
8
Long-term cardiovascular outcomes in patients with angina pectoris presenting with bundle branch block. (21439535)
2011
9
Recurrent variant angina pectoris due to BehAset's syndrome. (22041362)
2011
10
Angina pectoris: relation of epidemiological survey to registry data. (21450561)
2011
11
Using biomarkers to prioritise patients with stable angina pectoris for bypass surgery. (20089597)
2010
12
Angina pectoris in consequence of subtotal subclavian artery stenosis 2 years after CABG. (20072978)
2010
13
Effect of prodromal angina pectoris on the infarct progression in patients with first ST-elevation acute myocardial infarction. (20574134)
2010
14
Usefulness of breast arterial calcium detected on mammography for predicting coronary artery disease or cardiovascular events in women with angina pectoris and/or positive stress tests. (20102948)
2010
15
Cardiac hemangioma presenting with angina pectoris. (20678113)
2010
16
Impact of high-density lipoprotein cholesterol level in patients with variant angina pectoris. (19108908)
2010
17
Adhesion molecules and C-reactive protein are associated to adverse events in angina pectoris. (20184510)
2010
18
Depressive symptoms and all-cause mortality in unstable angina pectoris (from the Coronary Psychosocial Evaluation Studies [COPES]). (20920647)
2010
19
Evaluation of leptin and adiponectin levels in patients with stable angina pectoris. (22577414)
2010
20
Assessment of coronary plaque characteristics by optical coherence tomography in patients with diabetes mellitus complicated with unstable angina pectoris. (20951380)
2010
21
Enhanced external counterpulsation for chronic angina pectoris. (20166092)
2010
22
Clinical effects of calcium channel blocker and Angiotensin converting enzyme inhibitor on endothelial function and arterial stiffness in patients with angina pectoris. (19399262)
2009
23
Inflammatory responses after percutaneous coronary intervention in patients with acute myocardial infarction or stable angina pectoris. (19378426)
2008
24
Comparison of serum levels of inflammatory markers and allelic variant of interleukin-6 in patients with acute coronary syndrome and stable angina pectoris. (18281810)
2008
25
Chronic stable angina pectoris. (18725007)
2008
26
Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris. (18569954)
2008
27
Decreased circulating protective adiponectin level is associated with angiographic coronary disease progression in patients with angina pectoris. (17651832)
2008
28
Compound Salvia droplet pill, a traditional Chinese medicine, for the treatment of unstable angina pectoris: a systematic review. (18160949)
2008
29
Detection of coronary microembolization by Doppler ultrasound in patients with stable angina pectoris undergoing elective percutaneous coronary interventions. (17261655)
2007
30
Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischaemia: results in vasospastic angina pectoris induced by provocation test. (17967825)
2007
31
Plasma levels of B-type natriuretic Peptide in patients with unstable angina pectoris or acute myocardial infarction: prognostic significance and therapeutic implications. (17626979)
2007
32
Usefulness of high-frequency vascular ultrasound imaging and serum inflammatory markers to predict plaque rupture in patients with stable and unstable angina pectoris. (17950787)
2007
33
The cardiovascular risk factor, left ventricular hypertrophy, is highly prevalent in stable, treated angina pectoris. (17903683)
2007
34
Angina pectoris: has the cornerstone of symptomatic coronary artery disease been moved? (17593990)
2007
35
Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failure. (17293184)
2007
36
Essential thrombocythemia presenting as unstable angina pectoris: what should the cardiologist know? (16889850)
2007
37
Cardioselective beta-adrenoblockers in patients with stable angina pectoris. Comparison of efficacy and safety]. (17076224)
2006
38
Markers of inflammation--monocyte chemoattractant protein-1 (MCP-1) and C-reactive protein--in blood of patients with unstable angina pectoris and stable effort angina]. (16881366)
2006
39
The therapeutic effects of point massage for angina pectoris in 30 cases of coronary heart disease. (17078450)
2006
40
Lymphocyte activation in angina pectoris. (10527693)
1999
41
A comparative study of eccentric and concentric coronary stenosis vasomotion in patients with Prinzmental's variant angina and patients with stable angina pectoris. (9755380)
1998
42
Comparison of circulating endothelin-1 and big endothelin-1 levels in unstable versus stable angina pectoris. (9595409)
1998
43
Dose-response relationships of serum lipid measurements with the extent of coronary stenosis. Strong, independent, and comprehensive. ECAT Angina Pectoris Study Group. (7627693)
1995
44
Effects of intracoronary infusion of atrial natriuretic peptide on pacing-induced myocardial ischemia in patients with effort angina pectoris. (7728299)
1994
45
Correlation between clinical course and quantitative analysis of the ischemia related artery in patients with unstable angina pectoris, refractory to medical treatment. Results of two randomized trials. The European Cooperative Study Group. (7876657)
1994
46
The angiotensin-converting enzyme inhibitor in the treatment of angina pectoris]. (1568426)
1992
47
Plasminogen activator inhibitor-1 levels in patients with chronic angina pectoris with or without angiographic evidence of coronary sclerosis. (2119522)
1990
48
PRINZMETAL'S VARIANT ANGINA PECTORIS WITH NORMAL CORONARY ARTERIOGRAMS: EFFECT OF LONG-TERM RESERPINE TREATMENT. (15215975)
1974
49
Prinzmetal's variant angina pectoris. Report of a case. (5842523)
1965
50
Congenital dextrocardia with situs inversus complicated by hypertension and angina pectoris. (15434816)
1950

Genetic Variations for Angina Pectoris

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Expression for genes affiliated with Angina Pectoris

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angina Pectoris

Search GEO for disease gene expression data for Angina Pectoris.

Pathways for genes affiliated with Angina Pectoris

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 49PharmGKB
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Compounds for genes affiliated with Angina Pectoris

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Angina Pectoris according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1fibrinopeptide a4410.9PF4, FGA, SERPINC1, SERPINF2
2thromboxane44 2411.9AHSP, PF4, FGA, P2RY12, SERPINF2, EDN1
3ptca4410.9PF4, SERPINF2, FGA, SAA4, CHKB
4norepinephrine44 11 2412.9CHKB, SULT1A3, AHSP
5abciximab44 1111.9P2RY12, PF4, SERPINC1, CRP, CHKB
6aspirin44 49 28 2413.9P2RY12, FGA, PF4, CHKB, AHSP, SERPINC1
7heparin44 28 11 2413.9FGA, CPB2, P2RY12, PF4, AHSP, CHKB
86-ketoprostaglandin f1alpha4410.9EDN1, SERPINF2, FGA, PF4
9endotoxin4410.9CHKB, AHSP, FGA, SAA4
10homocysteine44 2411.9CRP, APOC3, SAA4, SULT1A3, SERPINC1, AHSP
11epinephrine44 11 2412.9FGA, P2RY12, CHKB, PF4, SERPINF2, EDN1
12tirofiban44 1111.9SERPINC1, P2RY12, PF4, CRP
13clopidogrel49 44 11 2413.9CHKB, P2RY12, SERPINC1, CRP
14fibrinogen4410.9APOC3, SULT1A3, SERPINC1, SERPINF2, CPB2, PF4
15ticlopidine44 1111.9PF4, FGA, P2RY12, SERPINC1
16prostacyclin4410.9EDN1, CRP, AHSP, FGA, PF4, SERPINC1
17cholesterol44 28 11 2413.9FGA, CPB2, SERPINF2, PTX3, PF4, SULT1A3
18thromboxane a244 2411.9PF4, AHSP, P2RY12, FGA, EDN1
19latex4410.8CHKB, PF4, CRP, SAA4, FGA
20nitroglycerin44 1111.8CHKB, AHSP, EDN1, CRP
21creatinine4410.8CHKB, EDN1, APOC3, CSNK1A1L, SAA4, CPB2
22hirudin4410.8FGA, SERPINC1, SERPINF2, PF4
23txb24410.8PF4, FGA, EDN1, SERPINF2
24ppack4410.8SERPINC1, P2RY12, FGA
25arginine4410.8CPB2, SERPINF2, SERPINC1, PF4, AHSP, CHKB
26calcium44 49 11 2413.8SERPINF2, CPB2, P2RY12, FGA, PF4, CCL18
27prostaglandin f2alpha4410.8AHSP, SAA4, CRP, EDN1
28malondialdehyde4410.8PF4, FGA, CHKB, CRP
29atp44 2811.8CHKB, NPY1R, APOC3, CSNK1A1L, AHSP, PF4
30lipid4410.8SAA4, APOC3, SERPINF2, SULT1A3, P2RY12, FGA
313-phosphoadenosine 5-phosphosulfate4410.8SERPINC1, SULT1A3, P2RY12
32nacl4410.8FGA, PF4, CHKB, SULT1A3, AHSP
33pge24410.8AHSP, PF4
34aprotinin44 1111.8PF4, FGA, SERPINC1, SERPINF2
35vegf4410.7SERPINF2, CRP, CCL18, CHKB, SERPINC1, PF4
36dopamine44 28 11 2413.7CHKB, PF4, TAF1, AHSP, SULT1A3, PTX3
37polyethylene glycol4410.7PF4, SERPINC1, CRP, CHKB
38adp44 28 2412.7CHKB, PF4, FGA, P2RY12, SERPINF2, AHSP
39nitric oxide44 11 2412.7EDN1, SULT1A3, AHSP, CHKB, APOC3, NPY1R
40alanine4410.7CCL18, CRP, CHKB, PF4, SERPINF2, TAF1
41cuprophan4410.7SERPINF2, FGA, PF4
42polysaccharide4410.7CHKB, APOC3, SERPINC1, SERPINF2, PF4
43atorvastatin44 49 28 11 2414.6EDN1, CHKB, CRP, APOC3
44polysulfone4410.6CRP, FGA, PF4
45diltiazem44 28 1112.6EDN1, SERPINC1, CHKB
46histamine44 28 2412.5FGA, AHSP, EDN1, PF4, NPY1R
47acetylcholine44 49 28 11 2414.5FGA, PF4, AHSP
48iloprost44 59 28 1113.4SERPINC1, EDN1, PF4
49citrate4410.4SERPINC1, PF4, CRP, CHKB
50rosuvastatin44 49 28 1113.2APOC3, CHKB, CRP

GO Terms for genes affiliated with Angina Pectoris

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16Gene Ontology
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Cellular components related to Angina Pectoris according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00557710.5SERPINF2, FGA
2extracellular spaceGO:00561510.4CPB2, CCL18, APOC3, EDN1, CRP, PF4
3extracellular regionGO:00557610.3SAA4, APOC3, EDN1, CRP, PF4, FGA
4platelet alpha granule lumenGO:03109310.2SERPINF2, FGA, PF4

Biological processes related to Angina Pectoris according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759610.6CPB2, PF4, FGA, P2RY12, GP5, SERPINC1
2platelet activationGO:03016810.6SERPINF2, GP5, P2RY12, FGA, PF4
3acute-phase responseGO:00695310.6SAA4, CRP, SERPINF2
4opsonizationGO:00822810.5PTX3, CRP
5negative regulation of fibrinolysisGO:05191810.5CPB2, SERPINF2
6fibrinolysisGO:04273010.5CPB2, SERPINF2
7platelet degranulationGO:00257610.4PF4, FGA, SERPINF2
8inflammatory responseGO:00695410.1PTX3, CRP, APOC3, CCL18

Products for genes affiliated with Angina Pectoris

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angina Pectoris

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet