MCID: ANG054
MIFTS: 43

Angina Pectoris malady

Cardiovascular diseases category

Summaries for Angina Pectoris

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Wikipedia:63 Angina pectoris ? commonly known as angina ? is the sensation of chest pain, pressure, or squeezing,... more...

MalaCards based summary: Angina Pectoris is related to coronary artery disease and ischemia. An important gene associated with Angina Pectoris is SERPINF2 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds fibrinopeptide a and 6-ketoprostaglandin f1alpha have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and spinal cord, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Angina Pectoris

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Sources:
31MalaCards, 30LifeMap Discovery®, 25ICD10
See all sources

Angina Pectoris, Aliases & Descriptions:

Name: Angina Pectoris 31 30


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

ICD1025 I20

Related Diseases for Angina Pectoris

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Diseases related to Angina Pectoris via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease31.1AHSP, CHKB, CRP, FGA
2ischemia31.1AHSP, CHKB, FGA
3myocardial infarction30.7AHSP, SERPINF2, SULT1A3, CHKB, P2RY12, CRP
4acute myocardial infarction30.6AHSP, SERPINF2, SULT1A3, CHKB, CRP, FGA
5pulmonary hypertension30.6FGA, AHSP
6amyloidosis30.5CRP
7atherosclerosis30.3AHSP, SERPINF2, SULT1A3, P2RY12, CRP, FGA
8vascular disease30.2AHSP, SULT1A3, P2RY12, CRP, FGA
9obesity30.0NPY1R, CRP, SULT1A3
10artery disease10.9
11prinzmetal's variant angina10.8
12endotheliitis10.8
13chronic angina10.7
14coronary stenosis10.6
15blindness10.6
16arteriosclerosis10.5
17coronary arterial fistulas10.5
18peripheral vascular disease10.4
19esophageal disease10.4
20esophagitis10.4
21diverticulitis10.4ACADS
22cardiac rupture10.4CHKB
23sleep disorder10.4CHKB
24collagen disease10.3CRP
25thrombophilia due to activated protein c resistance10.3SERPINF2, FGA
26factor v leiden thrombophilia10.3P2RY12, SERPINF2
27intermittent claudication10.3
28ischemic heart disease10.3
29intermediate coronary syndrome10.3
30cascade stomach10.3
31pernicious anemia10.3
32cervicitis10.3
33pneumonia10.3
34hyperlipidemia type 310.3
35spasticity10.3
36spinal cord infarction10.3
37pulmonary embolism10.3FGA, SERPINF2
38thrombophilia10.3SERPINF2, FGA
39coronary artery vasospasm10.3CHKB, AHSP
40stroke, ischemic10.2FGA, SULT1A3
41atrial fibrillation10.2CHKB, FGA
42preeclampsia/eclampsia 110.2FGA, SERPINF2, AHSP
43galactosemia10.2CHKB, SERPINF2
44prostate cancer10.2
45asthma10.2
46cerebrotendinous xanthomatosis10.2
47hepatic lipase deficiency10.2
48insulin-like growth factor i10.2
49pseudoxanthoma elasticum10.2
50fabry disease10.2

Graphical network of the top 20 diseases related to Angina Pectoris:



Diseases related to angina pectoris

Symptoms for Angina Pectoris

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Drugs & Therapeutics for Angina Pectoris

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Drug clinical trials:

Search ClinicalTrials for Angina Pectoris

Search NIH Clinical Center for Angina Pectoris

Genetic Tests for Angina Pectoris

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Anatomical Context for Angina Pectoris

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MalaCards organs/tissues related to Angina Pectoris:

31
Brain, Heart, Spinal cord, Endothelial, Testes, Monocytes, Neutrophil, Whole blood, Adipocyte, Lung, Breast, Prostate, T cells, Pituitary

Animal Models for Angina Pectoris or affiliated genes

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MGI Mouse Phenotypes related to Angina Pectoris:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.6FGA, NPY1R, CRP, ACADS, P2RY12, CHKB

Publications for Angina Pectoris

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Articles related to Angina Pectoris:

(show top 50)    (show all 731)
idTitleAuthorsYear
1
Effect of Preoperative Angina Pectoris on Cardiac Outcomes in Patients With Previous Myocardial Infarction Undergoing Major Noncardiac Surgery (Data from ACS-NSQIP). (25708862)
2015
2
Effect of preinfarction angina pectoris on long-term survival in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention. (25159235)
2014
3
Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris. (25367628)
2014
4
Recent characteristics and outcomes of Japanese stable angina pectoris after percutaneous coronary intervention. (24309441)
2013
5
Dramatic regression of three-vessel disease under statin treatment in patients with stable angina pectoris. (23196941)
2012
6
Ivabradine in combination with beta-blocker improves symptoms and quality of life in patients with stable angina pectoris: results from the ADDITIONS study. (22231643)
2012
7
Sulfotanshinone sodium injection for unstable angina pectoris: a systematic review of randomized controlled trials. (22548119)
2012
8
Risk of angina pectoris, non-fatal myocardial infarction and non-fatal stroke among hypertensives: the CroHort study. (22338762)
2012
9
Long-term cardiovascular outcomes in patients with angina pectoris presenting with bundle branch block. (21439535)
2011
10
Changes of dendritic cells and fractalkine in type 2 diabetic patients with unstable angina pectoris: a preliminary report. (21658276)
2011
11
Effects of enhanced external counterpulsation on arterial stiffness and myocardial oxygen demand in patients with chronic angina pectoris. (21420062)
2011
12
Influence of coronary computed tomographic angiography on patient treatment and prognosis in patients with suspected stable angina pectoris. (21420047)
2011
13
Logistic regression analysis of syndrome essential factors in patients with unstable angina pectoris. (22462230)
2011
14
Recent pioneering cardiology developments in Japan: Japanese cardiologists have discovered Waon therapy for severe or refractory heart failure and extracorporeal cardiac shock wave therapy for severe angina pectoris. (21879491)
2011
15
Prevalence of angina pectoris in Pelotas, south of Brazil. (20563514)
2010
16
Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris. (20019415)
2010
17
A young woman with angina pectoris: a brief report. (20097916)
2010
18
Using biomarkers to prioritise patients with stable angina pectoris for bypass surgery. (20089597)
2010
19
Angina pectoris in consequence of subtotal subclavian artery stenosis 2 years after CABG. (20072978)
2010
20
High-dose allopurinol in patients with stable angina pectoris. (20951884)
2010
21
Thrombus aspiration in a series of patients with stable or unstable angina pectoris and lesion-site thrombus formation. (20862237)
2010
22
Angina pectoris as first manifestation of a huge biatrial myxoma. (20058514)
2009
23
Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris. (18790543)
2009
24
Circulating secretory type IIA phospholipase A2, lipoprotein (a) and soluble cellular adhesion molecule levels in patients with angina pectoris. (18848929)
2008
25
Bleeding risk and outcomes of Bivalirudin versus Glycoprotein IIb/IIIa inhibitors with targeted low-dose unfractionated Heparin in patients having percutaneous coronary intervention for either stable or unstable angina pectoris. (18602514)
2008
26
Performing stable angina pectoris: an ethnographic study. (18237834)
2008
27
Angina pectoris during daily activities and exercise stress testing: The role of inducible myocardial ischemia and psychological distress. (18694624)
2008
28
A new method to quantify coronary calcification by intravascular ultrasound - the different patterns of calcification of acute myocardial infarction, unstable angina pectoris and stable angina pectoris. (18987398)
2008
29
Myocardial infarction and angina pectoris in the history of Polish medicine. Part 2. Diagnosis and early attempts at treatment: the 19th and 20th centuries. (18575427)
2008
30
Compliance, clinical outcome, and quality of life of patients with stable angina pectoris receiving once-daily betaxolol versus twice daily metoprolol: a randomized controlled trial. (17580734)
2007
31
Detection of coronary microembolization by Doppler ultrasound in patients with stable angina pectoris undergoing elective percutaneous coronary interventions. (17261655)
2007
32
Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: the first placebo-controlled randomised study. (17237126)
2007
33
The editor's roundtable: chronic stable angina pectoris. (18036361)
2007
34
The development of heart failure in patients with stable angina pectoris. (17079189)
2007
35
High probability of disease in angina pectoris patients: is clinical estimation reliable? (17593989)
2007
36
Usefulness of coronary computed tomographic angiography to assess suitability for revascularization in patients with significant coronary artery disease and angina pectoris. (17056327)
2006
37
New cut-off values of cardiac markers for risk stratification of angina pectoris. (15771924)
2005
38
Effect of tongxinluo capsule on function of vascular endothelium in patients with unstable angina pectoris]. (14503056)
2003
39
The effect of a neuropeptide Y Y1 receptor antagonist in patients with angina pectoris. (12804926)
2003
40
Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)
2002
41
Perioperative management of a patient requiring surgery for pituitary apoplexy and severe angina pectoris. (11094603)
2000
42
Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group. (11015339)
2000
43
Angina pectoris in leiomyoma]. (9757377)
1998
44
Coronary stenosis progression differs in patients with stable angina pectoris with and without a previous history of unstable angina. (8909904)
1996
45
Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS) (8682134)
1996
46
Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group. (7495059)
1995
47
The present status of treatment of unstable angina pectoris]. (8073649)
1994
48
Thiol-containing agents in the management of unstable angina pectoris and acute myocardial infarction. (1928201)
1991
49
Effects of glutamate on exercise tolerance and circulating substrate levels in stable angina pectoris. (1967510)
1990
50
Congenital dextrocardia with situs inversus complicated by hypertension and angina pectoris. (15434816)
1950

Variations for Angina Pectoris

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Expression for genes affiliated with Angina Pectoris

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LifeMap Discovery
Genes differentially expressed in tissues of Angina Pectoris patients vs. healthy controls: 30 (show all 18)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2ABrain-6.510.000
2GUCY1B3guanylate cyclase 1, soluble, beta 3Brain-6.510.000
3CAMK1Gcalcium/calmodulin-dependent protein kinase IGBrain-6.380.000
4KCNIP4Kv channel interacting protein 4Brain-6.380.000
5SLC23A2solute carrier family 23 (ascorbic acid transporter), member 2Brain-6.380.000
6ANKS1Bankyrin repeat and sterile alpha motif domain containing 1BBrain-6.160.000
7FARSBphenylalanyl-tRNA synthetase, beta subunitBrain-6.160.000
8PTPLAD1protein tyrosine phosphatase-like A domain containing 1Brain-6.160.000
9ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptideBrain-6.060.000
10FAM120Bfamily with sequence similarity 120BBrain-6.060.000
11ITFG1integrin alpha FG-GAP repeat containing 1Brain-6.060.000
12PRDM8PR domain containing 8Brain-6.060.000
13EGFEM1PEGF-like and EMI domain containing 1, pseudogeneBlood-4.440.000
14ZMYND11zinc finger, MYND-type containing 11Blood-4.320.000
15FFAR4free fatty acid receptor 4Blood-4.180.000
16PAQR9progestin and adipoQ receptor family member IXBlood-3.920.000
17EDNRBendothelin receptor type BBlood-3.920.002
18KIAA1462KIAA1462Blood-3.760.000

Search GEO for disease gene expression data for Angina Pectoris.

Pathways for genes affiliated with Angina Pectoris

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Pathways related to Angina Pectoris according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8FGA, SERPINF2
29.8FGA, P2RY12
3
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)36
Fatty Acid Beta Oxidation36
9.4ACADS, CHKB
4
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.0FGA, CPB2, SERPINF2

Compounds for genes affiliated with Angina Pectoris

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Sources:
43Novoseek, 12DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
See all sources

Compounds related to Angina Pectoris according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1fibrinopeptide a4310.2SERPINF2, FGA
26-ketoprostaglandin f1alpha4310.2SERPINF2, FGA
3cuprophan4310.1SERPINF2, FGA
4ppack4310.1P2RY12, FGA
5ticlopidine43 1211.1FGA, P2RY12
6guanidino4310.0AHSP, CHKB
7hirudin4310.0FGA, SERPINF2
83-phosphoadenosine 5-phosphate4310.0SULT1A3, P2RY12
93-phosphoadenosine 5-phosphosulfate4310.0P2RY12, SULT1A3
10thromboxane a243 2410.8FGA, P2RY12, AHSP
11phosphocreatine43 2410.8P2RY12, CHKB
12convulxin439.8CRP, P2RY12
13tirofiban43 1210.8P2RY12, CRP
14polysulfone439.8FGA, CRP
15ptca439.8SERPINF2, CHKB, FGA
16txb2439.7FGA, SERPINF2
17phosphorylcholine43 2410.6CRP, CHKB
18thromboxane43 2410.6FGA, P2RY12, SERPINF2, AHSP
19histamine43 28 2411.6FGA, NPY1R, AHSP
20rosuvastatin43 49 28 1212.6CRP, CHKB
21methacholine43 49 1211.6CRP, AHSP
22prostacyclin439.5FGA, CRP, AHSP
23cerivastatin49 43 28 1212.5CHKB, CRP
24homocysteine43 2410.5CRP, SULT1A3, AHSP
25nitroglycerin43 1210.4AHSP, CHKB, CRP
26bezafibrate43 28 1211.4CRP, CHKB
27malondialdehyde439.4FGA, CRP, CHKB
28abciximab43 1210.4CRP, P2RY12, CHKB
29clopidogrel43 49 24 1212.4CRP, P2RY12, CHKB
30latex439.4CHKB, CRP, FGA
31acetylcholine43 49 28 24 1213.3AHSP, CRP, FGA
32nacl439.3AHSP, SULT1A3, CHKB, FGA
33carnitine439.2CRP, ACADS, CHKB
34nitric oxide43 24 1211.1AHSP, SULT1A3, CHKB, NPY1R
35glutamate439.0AHSP, CHKB, ACADS, CSNK1A1L
36adp43 28 2411.0AHSP, SERPINF2, CHKB, P2RY12, FGA
37potassium43 24 1211.0FGA, CHKB, AHSP
38epinephrine43 24 1210.9SERPINF2, SULT1A3, CHKB, P2RY12, FGA
39endotoxin438.8AHSP, SERPINF2, CHKB, CRP, FGA
40estrogen438.8AHSP, SULT1A3, CHKB, NPY1R
41norepinephrine43 24 1210.7AHSP, SULT1A3, CHKB, CRP, FGA
42atp43 289.6AHSP, CHKB, P2RY12, CSNK1A1L, NPY1R, FGA
43arginine438.5AHSP, SERPINF2, SULT1A3, CPB2, CHKB
44aspirin43 49 28 2411.3AHSP, SULT1A3, CHKB, P2RY12, CRP, FGA
45lipid438.0AHSP, SERPINF2, SULT1A3, P2RY12, ACADS, CRP
46heparin43 28 24 1210.8AHSP, SERPINF2, SULT1A3, CPB2, CHKB, P2RY12
47cholesterol43 28 24 1210.6AHSP, SERPINF2, SULT1A3, CPB2, CHKB, CRP
48creatinine437.5SULT1A3, CPB2, CHKB, P2RY12, CSNK1A1L, CRP
49calcium43 49 24 1210.2AHSP, SERPINF2, CPB2, CHKB, P2RY12, CRP
50fibrinogen437.2FGA, AHSP, SERPINF2, SULT1A3, CPB2, CHKB

GO Terms for genes affiliated with Angina Pectoris

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Cellular components related to Angina Pectoris according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibrinogen complexGO:00055779.7FGA, SERPINF2
2platelet alpha granule lumenGO:00310939.5FGA, SERPINF2
3extracellular spaceGO:00056158.4FGA, CRP, CPB2, SERPINF2

Biological processes related to Angina Pectoris according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00069539.6CRP, SERPINF2
2negative regulation of plasminogen activationGO:00107579.5CPB2, SERPINF2
3negative regulation of fibrinolysisGO:00519189.5CPB2, SERPINF2
4platelet activationGO:00301689.4FGA, P2RY12, SERPINF2
5fibrinolysisGO:00427309.4SERPINF2, CPB2
6protein polymerizationGO:00512589.2FGA, CRP
7blood coagulationGO:00075968.7FGA, P2RY12, CPB2, SERPINF2

Products for genes affiliated with Angina Pectoris

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Sources for Angina Pectoris

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet