MCID: ANG050
MIFTS: 28

Angiocentric Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Angiocentric Glioma

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32MalaCards
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MalaCards: Angiocentric Glioma is related to astrocytoma and frontal lobe epilepsy. An important gene associated with Angiocentric Glioma is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways are Striated Muscle Contraction and Cell adhesion Cadherin-mediated cell adhesion. The compounds 4-aminopyridine and 2-methoxyethanol have been mentioned in the context of this disorder. Related mouse phenotype normal.

Aliases & Classifications for Angiocentric Glioma

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48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
angiocentric glioma:
Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

angiocentric glioma 48 60


External Ids:

SNOMED-CT via Orphanet57 450900009

Related Diseases for Angiocentric Glioma

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17GeneCards, 18GeneDecks
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Diseases related to Angiocentric Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.4VIM, IDH1, S100B, SYP, GFAP
2frontal lobe epilepsy10.1
3temporal lobe epilepsy10.1
4pilomyxoid astrocytoma10.1
5brain glioma10.1
6focal epilepsy10.1
7dysembryoplastic neuroepithelial tumor10.0SYP
8melanotic neuroectodermal tumor10.0SYP
9papilloma10.0ACTC1
10hemangioma10.0ACTC1
11medulloepithelioma10.0SYP
12fasciitis10.0ACTC1
13merkel cell carcinoma10.0SYP
14clear cell ependymoma10.0VIM
15histiocytosis10.0S100B
16down syndrome10.0S100B
17thymus cancer10.0SYP
18gliosarcoma10.0GFAP
19giant cell glioblastoma10.0GFAP
20choroid plexus papilloma10.0GFAP
21mixed glioma10.0GFAP
22anaplastic astrocytoma10.0GFAP
23colorectal cancer10.0PTPRJ
24ganglioneuroblastoma10.0S100B, SYP
25gliomatosis cerebri10.0GFAP
26angiomyolipoma10.0VIM, ACTC1
27neurilemmoma10.0GFAP
28subependymal giant cell astrocytoma10.0SYP, S100B
29olfactory neuroblastoma10.0SYP, S100B
30epithelioid leiomyosarcoma10.0VIM, ACTC1
31wilms tumor10.0ACTC1, VIM
32chondrosarcoma10.0S100B, VIM
33pseudosarcomatous fibromatosis10.0VIM, ACTC1
34angiosarcoma10.0ACTC1, VIM
35tubular adenocarcinoma10.0ACTC1, SYP
36spindle cell carcinoma10.0VIM, ACTC1
37cutaneous fibrous histiocytoma10.0ACTC1, S100B
38parkinson's disease10.0VIM
39endometrial stromal sarcoma10.0ACTC1, VIM
40sertoli cell tumor10.0VIM, SYP
41abrikosov's tumor10.0ACTC1, VIM
42pituitary adenoma10.0SYP
43sex cord-gonadal stromal tumor10.0VIM, S100B
44perineurioma10.0VIM, S100B
45oxyphilic adenoma10.0VIM, SYP
46malignant peripheral nerve sheath tumor10.0S100B, VIM
47neuroendocrine carcinoma10.0S100B, SYP
48binswanger's disease10.0SYP, GFAP
49teratoma10.0ACTC1, GFAP
50central neurocytoma10.0GFAP, SYP

Graphical network of the top 20 diseases related to Angiocentric Glioma:



Diseases related to angiocentric glioma

Clinical Features for Angiocentric Glioma

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Drugs & Therapeutics for Angiocentric Glioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Angiocentric Glioma

Search CenterWatch for Angiocentric Glioma

Genetic Tests for Angiocentric Glioma

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Anatomical Context for Angiocentric Glioma

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Animal Models for Angiocentric Glioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiocentric Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.6PTPRJ, ACTC1, GFAP, SYP, S100B

Publications for Angiocentric Glioma

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Genetic Variations for Angiocentric Glioma

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Expression for genes affiliated with Angiocentric Glioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiocentric Glioma

Search GEO for disease gene expression data for Angiocentric Glioma.

Pathways for genes affiliated with Angiocentric Glioma

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Angiocentric Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5ACTC1, VIM
29.4PTPRJ, ACTC1
3
Hide members
9.1GFAP, S100B
48.7GFAP, SYP, S100B

Compounds for genes affiliated with Angiocentric Glioma

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Angiocentric Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
14-aminopyridine44 2811.3SYP
22-methoxyethanol449.8VIM, ACTC1
3acetylcholine44 49 28 11 2413.6SYP, GFAP
4l-amino acid449.6SYP, S100B
5n-acetylaspartate449.6SYP, GFAP
62,3-cyclic nucleotide449.4S100B, GFAP
7orcein449.4VIM, ACTC1, S100B
8retinaldehyde449.4VIM, GFAP
9catecholamine449.4SYP, S100B, VIM
10silicone449.3GFAP, VIM
11glutamine449.3SYP, GFAP, IDH1
12etoposide44 49 59 1112.1VIM, S100B, SYP
13streptozotocin449.1GFAP, SYP, VIM
14ganglioside449.1SYP, GFAP, VIM
15eosin449.0GFAP, S100B, VIM
165-hydroxytryptamine449.0SYP, GFAP, VIM
17mucicarmine449.0SYP, VIM, S100B, ACTC1
18b 723449.0S100B, ACTC1, SYP, VIM
19acth449.0GFAP, SYP, S100B
20cocaine44 119.9S100B, VIM, GFAP
21bromodeoxyuridine448.9GFAP, S100B, VIM
22matrigel448.8ACTC1, GFAP, VIM
23ethanol44 49 11 2411.7SYP, S100B, GFAP
24dbc-amp448.6SYP, S100B, GFAP, VIM
25nmda44 289.6SYP, VIM, GFAP
26choline44 11 2410.6GFAP, SYP, VIM, S100B
27methionine448.6S100B, GFAP, VIM
28gaba448.6GFAP, VIM, SYP, S100B
29forskolin44 49 1110.6GFAP, S100B, SYP, VIM
30leucine448.5GFAP, SYP, S100B, VIM
31cyclic amp44 249.5GFAP, SYP, S100B, VIM
32iron44 249.5VIM, ACTC1, S100B, GFAP
33paclitaxel44 49 1110.3VIM, S100B, GFAP
34glutamate448.2VIM, GFAP, SYP, S100B, IDH1
35s 100448.2VIM, S100B, SYP, GFAP, ACTC1
36reticulin448.2ACTC1, S100B, VIM, SYP, GFAP
37hematoxylin448.2ACTC1, S100B, VIM, GFAP, SYP
38formaldehyde44 249.2GFAP, VIM, S100B, ACTC1, SYP
39glycogen44 249.2S100B, VIM, SYP, ACTC1, GFAP
40paraffin448.2ACTC1, GFAP, VIM, SYP, S100B
41creatinine448.2GFAP, ACTC1, SYP, S100B, VIM
42progesterone44 59 28 11 2412.2VIM, GFAP, ACTC1, SYP, S100B
43testosterone44 59 11 2411.2ACTC1, SYP, S100B, VIM, GFAP
44dexamethasone44 49 28 1111.1S100B, ACTC1, VIM, GFAP, SYP
45vegf448.1VIM, GFAP, SYP, S100B, ACTC1
46estrogen448.1S100B, SYP, GFAP, ACTC1, VIM
47retinoic acid44 249.1GFAP, SYP, S100B, VIM, ACTC1
48tyrosine447.8PTPRJ, S100B, SYP, ACTC1, GFAP
49serine447.8PTPRJ, VIM, S100B, SYP, GFAP
50calcium44 49 11 2410.6PTPRJ, ACTC1, GFAP, SYP, S100B, IDH1

GO Terms for genes affiliated with Angiocentric Glioma

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16Gene Ontology
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Biological processes related to Angiocentric Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5ACTC1, VIM
2Bergmann glial cell differentiationGO:0600209.2GFAP, VIM
3astrocyte developmentGO:0140029.2GFAP, VIM
4intermediate filament organizationGO:0451099.1GFAP, VIM
5long-term synaptic potentiationGO:0602919.0S100B, GFAP
6negative regulation of neuron projection developmentGO:0109778.8GFAP, VIM

Products for genes affiliated with Angiocentric Glioma

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  • Antibodies
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Sources for Angiocentric Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet