MCID: ANG050
MIFTS: 40

Angiocentric Glioma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Angiocentric Glioma

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33MalaCards
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MalaCards: Angiocentric Glioma is related to ependymoma and astrocytoma. An important gene associated with Angiocentric Glioma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Nuclear signaling by ERBB4. The compounds 2-methoxyethanol and n-acetylaspartate have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe and brain, and related mouse phenotypes are muscle and homeostasis/metabolism.

Aliases & Classifications for Angiocentric Glioma

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49Orphanet, 62UMLS, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
angiocentric glioma:
Prevalence: <1/1000000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

angiocentric glioma 49 62


External Ids:

SNOMED-CT via Orphanet59 450900009
UMLS via Orphanet63 C2363903

Related Diseases for Angiocentric Glioma

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17GeneCards, 18GeneDecks
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Diseases related to Angiocentric Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1ependymoma30.4S100B, SYP, VIM, GFAP
2astrocytoma30.3IDH1, GFAP, VIM, SYP, S100B
3frontal lobe epilepsy10.2
4temporal lobe epilepsy10.2
5pilomyxoid astrocytoma10.2
6pituicytoma10.2
7dysembryoplastic neuroepithelial tumor10.1SYP
8melanotic neuroectodermal tumor10.1SYP
9giant cell glioblastoma10.1GFAP
10choroid plexus papilloma10.1GFAP
11histiocytosis10.1S100B
12mixed glioma10.1GFAP
13papilloma10.1ACTC1
14neurilemmoma10.1GFAP
15gliomatosis cerebri10.1GFAP
16gliosarcoma10.1GFAP
17epithelioid leiomyosarcoma10.1VIM, ACTC1
18pseudosarcomatous fibromatosis10.1VIM, ACTC1
19spindle cell carcinoma10.1VIM, ACTC1
20cutaneous fibrous histiocytoma10.1ACTC1, S100B
21tubular adenocarcinoma10.1ACTC1, SYP
22endometrial stromal sarcoma10.1VIM, ACTC1
23angiomyolipoma10.1ACTC1, VIM
24fibroma10.1VIM, ACTC1
25fibromatosis10.1ACTC1, VIM
26subependymal giant cell astrocytoma10.1SYP, S100B
27olfactory neuroblastoma10.1SYP, S100B
28angiosarcoma10.1VIM, ACTC1
29sertoli cell tumor10.0VIM, SYP
30ganglioneuroblastoma10.0SYP, S100B
31abrikosov's tumor10.0VIM, ACTC1
32binswanger's disease10.0GFAP, SYP
33central neurocytoma10.0GFAP, SYP
34syringoma10.0GFAP, S100B
35perineurioma10.0S100B, VIM
36sex cord-gonadal stromal tumor10.0VIM, S100B
37microphthalmia10.0S100B, ACTC1
38amyotrophic lateral sclerosis10.0SYP, GFAP
39myxopapillary ependymoma10.0S100B, GFAP
40oxyphilic adenoma10.0SYP, VIM
41pineoblastoma10.0GFAP, SYP
42rhabdoid meningioma10.0VIM, GFAP
43astroblastoma10.0GFAP, VIM
44neuroendocrine carcinoma10.0S100B, SYP
45choroid plexus carcinoma10.0S100B, GFAP
46anaplastic ependymoma10.0GFAP, S100B
47gemistocytic astrocytoma10.0GFAP, S100B
48malignant peripheral nerve sheath tumor10.0VIM, S100B
49teratoma10.0ACTC1, GFAP
50benign mesothelioma10.0ACTC1, VIM

Graphical network of the top 20 diseases related to Angiocentric Glioma:



Diseases related to angiocentric glioma

Symptoms for Angiocentric Glioma

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Drugs & Therapeutics for Angiocentric Glioma

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Angiocentric Glioma

Search NIH Clinical Center for Angiocentric Glioma

Genetic Tests for Angiocentric Glioma

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Anatomical Context for Angiocentric Glioma

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33MalaCards
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MalaCards organs/tissues related to Angiocentric Glioma:

33
Temporal lobe, Brain

Animal Models for Angiocentric Glioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Angiocentric Glioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.8GFAP, PTPRJ, VIM, ACTC1
2MP:00053767.7ACTC1, VIM, PTPRJ, GFAP, IDH1
3MP:00028737.6S100B, SYP, ACTC1, PTPRJ, GFAP

Publications for Angiocentric Glioma

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52PubMed
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Articles related to Angiocentric Glioma:

(show all 26)
idTitleAuthorsYear
1
Intractable epilepsy due to angiocentric glioma: A case report and minireview. (24348765)
2014
2
Angiocentric glioma: clinical, morphological, immunohistochemical and molecular features in three pediatric cases. (23073165)
2013
3
Angiocentric glioma. (24116979)
2013
4
The treatment of angiocentric glioma: case report and literature review. (23596378)
2013
5
Angiocentric glioma in a 4-year-old boy: imaging characteristics and review of the literature. (22226445)
2012
6
Adult-onset angiocentric glioma of epithelioid cell-predominant type of the mesial temporal lobe suggestive of a rare but distinct clinicopathological subset within a spectrum of angiocentric cortical ependymal tumors. (22151480)
2012
7
Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature. (23378871)
2012
8
Isocitrate dehydrogenase 1 R132H mutation is not detected in angiocentric glioma. (22445362)
2012
9
Refractory temporal lobe epilepsy caused by angiocentric glioma complicated with focal cortical dysplasia: a surgical case series. (23065092)
2012
10
The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma. (21892765)
2012
11
Angiocentric glioma and surrounding cortical dysplasia manifesting as intractable frontal lobe epilepsy--case report. (21785249)
2011
12
Angiocentric glioma: a clinicopathologic review of 5 tumors with identification of associated cortical dysplasia. (21809996)
2011
13
A case of angiocentric glioma with unusual clinical and radiological features. (21887397)
2011
14
Angiocentric glioma with high proliferative index: case report and review of the literature. (22075509)
2011
15
Paroxysmal ictal phonemes in a patient with angiocentric glioma. (20160231)
2010
16
Angiocentric glioma with rich blood supply. (20399664)
2010
17
Angiocentric glioma: a case report and review of the literature. (19941376)
2010
18
Angiocentric glioma: a case series. (19338465)
2009
19
Angiocentric glioma-like tumor of the midbrain. (20110754)
2009
20
Angiocentric glioma-induced seizures in a 2-year-old child. (19304961)
2009
21
Brain surface spindle cell glioma in a patient with medically intractable partial epilepsy: a variant of monomorphous angiocentric glioma? (18179412)
2008
22
Cortical ependymoma or monomorphous angiocentric glioma? (18021197)
2008
23
Angiocentric glioma: presentation of two cases with dissimilar histology. (19130736)
2008
24
Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. (17598825)
2007
25
Angiocentric glioma: report of clinico-pathologic and genetic findings in 8 cases. (18059228)
2007
26
Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. (16215459)
2005

Variations for Angiocentric Glioma

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Expression for genes affiliated with Angiocentric Glioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiocentric Glioma

Search GEO for disease gene expression data for Angiocentric Glioma.

Pathways for genes affiliated with Angiocentric Glioma

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Angiocentric Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6ACTC1, VIM
2
Show member pathways
9.3S100B, GFAP
39.3ACTC1, PTPRJ
48.9S100B, SYP, GFAP

Compounds for genes affiliated with Angiocentric Glioma

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45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Angiocentric Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol459.9ACTC1, VIM
2n-acetylaspartate459.7SYP, GFAP
34-aminopyridine45 2910.7SYP, VIM
42,3-cyclic nucleotide459.6S100B, GFAP
5retinaldehyde459.6GFAP, VIM
6l-amino acid459.5SYP, S100B
7orcein459.5ACTC1, S100B, VIM
8silicone459.4GFAP, VIM
9catecholamine459.3S100B, VIM, SYP
10streptozotocin459.3GFAP, VIM, SYP
11eosin459.2S100B, VIM, GFAP
12ganglioside459.2GFAP, SYP, VIM
135-hydroxytryptamine459.2SYP, VIM, GFAP
14matrigel459.2VIM, GFAP, ACTC1
15cocaine45 1110.1GFAP, VIM, S100B
16etoposide45 51 61 1112.1SYP, S100B, VIM
17bromodeoxyuridine459.1GFAP, VIM, S100B
18acth459.1S100B, GFAP, SYP
19mucicarmine459.0SYP, ACTC1, VIM, S100B
20b 723459.0S100B, SYP, ACTC1, VIM
21methionine458.9GFAP, S100B, VIM
22iron45 249.8S100B, ACTC1, VIM, GFAP
23dbc-amp458.8S100B, VIM, GFAP, SYP
24nmda45 299.8SYP, GFAP, VIM
25choline45 24 1110.8VIM, GFAP, SYP, S100B
26gaba458.8VIM, S100B, GFAP, SYP
27acetylcholine45 51 29 24 1112.7GFAP, VIM, SYP, S100B
28forskolin45 51 1110.7SYP, VIM, GFAP, S100B
29leucine458.7VIM, SYP, S100B, GFAP
30cyclic amp45 249.7GFAP, S100B, SYP, VIM
31ethanol45 51 24 1111.6GFAP, S100B, SYP
32s 100458.4SYP, GFAP, VIM, ACTC1, S100B
33reticulin458.4S100B, ACTC1, GFAP, VIM, SYP
34hematoxylin458.4S100B, SYP, ACTC1, GFAP, VIM
35formaldehyde45 249.4GFAP, VIM, ACTC1, SYP, S100B
36glycogen45 249.4S100B, VIM, ACTC1, SYP, GFAP
37paraffin458.4SYP, ACTC1, VIM, GFAP, S100B
38creatinine458.4S100B, SYP, VIM, GFAP, ACTC1
39progesterone45 29 61 24 1112.4GFAP, ACTC1, SYP, S100B, VIM
40testosterone45 61 24 1111.4ACTC1, VIM, GFAP, SYP, S100B
41dexamethasone45 51 29 1111.4VIM, GFAP, S100B, SYP, ACTC1
42vegf458.4GFAP, S100B, SYP, ACTC1, VIM
43glutamine458.4S100B, VIM, GFAP, IDH1, SYP
44estrogen458.4SYP, GFAP, ACTC1, S100B, VIM
45retinoic acid45 249.4SYP, ACTC1, VIM, GFAP, S100B
46cysteine458.4VIM, GFAP, SYP, S100B
47glutamate458.3SYP, VIM, IDH1, GFAP, S100B
48tyrosine457.9S100B, SYP, ACTC1, GFAP, PTPRJ
49serine457.8PTPRJ, VIM, SYP, S100B, GFAP
50calcium45 51 24 1110.6IDH1, PTPRJ, ACTC1, GFAP, SYP, S100B

GO Terms for genes affiliated with Angiocentric Glioma

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16Gene Ontology
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Cellular components related to Angiocentric Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.5VIM, IDH1
2intermediate filamentGO:0058829.0VIM, GFAP
3extracellular vesicular exosomeGO:0700628.2ACTC1, VIM, PTPRJ, IDH1

Biological processes related to Angiocentric Glioma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.6ACTC1, VIM
2regulation of neuronal synaptic plasticityGO:0481689.5SYP, S100B
3Bergmann glial cell differentiationGO:0600209.5VIM, GFAP
4astrocyte developmentGO:0140029.4VIM, GFAP
5intermediate filament organizationGO:0451099.4VIM, GFAP
6long-term synaptic potentiationGO:0602919.2S100B, GFAP
7negative regulation of neuron projection developmentGO:0109779.0VIM, GFAP

Molecular functions related to Angiocentric Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3VIM, GFAP
2identical protein bindingGO:0428028.7S100B, SYP, VIM

Products for genes affiliated with Angiocentric Glioma

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Sources for Angiocentric Glioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet