MCID: ANG050
MIFTS: 39

Angiocentric Glioma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Angiocentric Glioma

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MalaCards based summary: Angiocentric Glioma is related to dysembryoplastic neuroepithelial tumor and oligodendroglioma. An important gene associated with Angiocentric Glioma is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Striated Muscle Contraction and Nuclear signaling by ERBB4. The compounds 2-methoxyethanol and n-acetylaspartate have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe and brain, and related mouse phenotypes are muscle and homeostasis/metabolism.

Aliases & Classifications for Angiocentric Glioma

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48Orphanet, 62UMLS, 63UMLS via Orphanet
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Angiocentric Glioma, Aliases & Descriptions:

Name: Angiocentric Glioma 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
angiocentric glioma:
Prevalence: <1/1000000; Age of onset: Variable; Age of death: Normal


External Ids:

UMLS via Orphanet63 C2363903

Related Diseases for Angiocentric Glioma

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Diseases related to Angiocentric Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor31.0SYP
2oligodendroglioma30.3IDH1, GFAP, SYP
3ependymoma30.2S100B, SYP, VIM, GFAP
4astrocytoma29.9IDH1, GFAP, SYP, VIM, S100B
5melanotic neuroectodermal tumor10.5SYP
6giant cell glioblastoma10.4GFAP
7choroid plexus papilloma10.4GFAP
8histiocytosis10.4S100B
9mixed glioma10.4GFAP
10papilloma10.4ACTC1
11neurilemmoma10.4GFAP
12gliomatosis cerebri10.4GFAP
13gliosarcoma10.3GFAP
14epithelioid leiomyosarcoma10.3ACTC1, VIM
15pseudosarcomatous fibromatosis10.3ACTC1, VIM
16spindle cell carcinoma10.3VIM, ACTC1
17cutaneous fibrous histiocytoma10.3ACTC1, S100B
18tubular adenocarcinoma10.3ACTC1, SYP
19endometrial stromal sarcoma10.2VIM, ACTC1
20angiomyolipoma10.2ACTC1, VIM
21fibroma10.2VIM, ACTC1
22subependymal giant cell astrocytoma10.2S100B, SYP
23fibromatosis10.2VIM, ACTC1
24olfactory neuroblastoma10.2SYP, S100B
25angiosarcoma10.2VIM, ACTC1
26sertoli cell tumor10.2SYP, VIM
27ganglioneuroblastoma10.2S100B, SYP
28abrikosov's tumor10.2ACTC1, VIM
29binswanger's disease10.2GFAP, SYP
30temporal lobe epilepsy10.2
31pilomyxoid astrocytoma10.2
32frontal lobe epilepsy10.2
33pituicytoma10.2
34syringoma10.2GFAP, S100B
35central neurocytoma10.2SYP, GFAP
36perineurioma10.2S100B, VIM
37sex cord-gonadal stromal tumor10.2S100B, VIM
38microphthalmia10.2ACTC1, S100B
39amyotrophic lateral sclerosis type 1410.2SYP, GFAP
40myxopapillary ependymoma10.2GFAP, S100B
41neuroendocrine carcinoma10.2S100B, SYP
42rhabdoid meningioma10.2GFAP, VIM
43pineoblastoma10.2GFAP, SYP
44astroblastoma10.2VIM, GFAP
45oxyphilic adenoma10.2SYP, VIM
46choroid plexus carcinoma10.2S100B, GFAP
47anaplastic ependymoma10.2S100B, GFAP
48gemistocytic astrocytoma10.2GFAP, S100B
49teratoma10.1GFAP, ACTC1
50malignant peripheral nerve sheath tumor10.1VIM, S100B

Graphical network of the top 20 diseases related to Angiocentric Glioma:



Diseases related to angiocentric glioma

Symptoms for Angiocentric Glioma

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Drugs & Therapeutics for Angiocentric Glioma

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Drug clinical trials:

Search ClinicalTrials for Angiocentric Glioma

Search NIH Clinical Center for Angiocentric Glioma

Genetic Tests for Angiocentric Glioma

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Anatomical Context for Angiocentric Glioma

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MalaCards organs/tissues related to Angiocentric Glioma:

32
Temporal lobe, Brain

Animal Models for Angiocentric Glioma or affiliated genes

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MGI Mouse Phenotypes related to Angiocentric Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053697.8GFAP, PTPRJ, VIM, ACTC1
2MP:00053767.7ACTC1, VIM, PTPRJ, GFAP, IDH1
3MP:00028737.6S100B, SYP, ACTC1, PTPRJ, GFAP

Publications for Angiocentric Glioma

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Articles related to Angiocentric Glioma:

(show all 30)
idTitleAuthorsYear
1
Angiocentric glioma: A report of nine new cases, including four with atypical histological features. (24861831)
2014
2
Angiocentric glioma: a rare intractable epilepsy-related tumour in children. (25310736)
2014
3
Angiocentric Glioma: The Infiltrative Glioma with Ependymal Differentiation. (24913299)
2014
4
Intractable epilepsy due to angiocentric glioma: A case report and minireview. (24348765)
2014
5
Well-differentiated pediatric glial neoplasms with features of oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumors: a morphological diagnostic challenge. (24448703)
2014
6
Angiocentric glioma: clinical, morphological, immunohistochemical and molecular features in three pediatric cases. (23073165)
2013
7
Angiocentric glioma. (24116979)
2013
8
The treatment of angiocentric glioma: case report and literature review. (23596378)
2013
9
Angiocentric glioma in a 4-year-old boy: imaging characteristics and review of the literature. (22226445)
2012
10
Adult-onset angiocentric glioma of epithelioid cell-predominant type of the mesial temporal lobe suggestive of a rare but distinct clinicopathological subset within a spectrum of angiocentric cortical ependymal tumors. (22151480)
2012
11
Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature. (23378871)
2012
12
Isocitrate dehydrogenase 1 R132H mutation is not detected in angiocentric glioma. (22445362)
2012
13
Refractory temporal lobe epilepsy caused by angiocentric glioma complicated with focal cortical dysplasia: a surgical case series. (23065092)
2012
14
The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma. (21892765)
2012
15
Angiocentric glioma and surrounding cortical dysplasia manifesting as intractable frontal lobe epilepsy--case report. (21785249)
2011
16
Angiocentric glioma: a clinicopathologic review of 5 tumors with identification of associated cortical dysplasia. (21809996)
2011
17
A case of angiocentric glioma with unusual clinical and radiological features. (21887397)
2011
18
Angiocentric glioma with high proliferative index: case report and review of the literature. (22075509)
2011
19
Paroxysmal ictal phonemes in a patient with angiocentric glioma. (20160231)
2010
20
Angiocentric glioma with rich blood supply. (20399664)
2010
21
Angiocentric glioma: a case report and review of the literature. (19941376)
2010
22
Angiocentric glioma: a case series. (19338465)
2009
23
Angiocentric glioma-like tumor of the midbrain. (20110754)
2009
24
Angiocentric glioma-induced seizures in a 2-year-old child. (19304961)
2009
25
Brain surface spindle cell glioma in a patient with medically intractable partial epilepsy: a variant of monomorphous angiocentric glioma? (18179412)
2008
26
Cortical ependymoma or monomorphous angiocentric glioma? (18021197)
2008
27
Angiocentric glioma: presentation of two cases with dissimilar histology. (19130736)
2008
28
Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. (17598825)
2007
29
Angiocentric glioma: report of clinico-pathologic and genetic findings in 8 cases. (18059228)
2007
30
Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. (16215459)
2005

Variations for Angiocentric Glioma

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Expression for genes affiliated with Angiocentric Glioma

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Expression patterns in normal tissues for genes affiliated with Angiocentric Glioma

Search GEO for disease gene expression data for Angiocentric Glioma.

Pathways for genes affiliated with Angiocentric Glioma

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Pathways related to Angiocentric Glioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6ACTC1, VIM
2
Show member pathways
9.3S100B, GFAP
39.3ACTC1, PTPRJ
48.9S100B, SYP, GFAP

Compounds for genes affiliated with Angiocentric Glioma

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Compounds related to Angiocentric Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol449.9ACTC1, VIM
2n-acetylaspartate449.7SYP, GFAP
34-aminopyridine44 2810.7SYP, VIM
42,3-cyclic nucleotide449.6S100B, GFAP
5retinaldehyde449.6GFAP, VIM
6l-amino acid449.5SYP, S100B
7orcein449.5ACTC1, S100B, VIM
8silicone449.4GFAP, VIM
9catecholamine449.3S100B, VIM, SYP
10streptozotocin449.3GFAP, VIM, SYP
11eosin449.2S100B, VIM, GFAP
12ganglioside449.2GFAP, SYP, VIM
135-hydroxytryptamine449.2SYP, VIM, GFAP
14matrigel449.2VIM, GFAP, ACTC1
15cocaine44 1110.1GFAP, VIM, S100B
16etoposide44 50 61 1112.1SYP, S100B, VIM
17bromodeoxyuridine449.1GFAP, VIM, S100B
18acth449.1S100B, GFAP, SYP
19mucicarmine449.0SYP, ACTC1, VIM, S100B
20b 723449.0S100B, SYP, ACTC1, VIM
21methionine448.9GFAP, S100B, VIM
22iron44 249.8S100B, ACTC1, VIM, GFAP
23dbc-amp448.8S100B, VIM, GFAP, SYP
24nmda44 289.8SYP, GFAP, VIM
25choline44 24 1110.8VIM, GFAP, SYP, S100B
26gaba448.8VIM, S100B, GFAP, SYP
27acetylcholine44 50 28 24 1112.7GFAP, VIM, SYP, S100B
28forskolin44 50 1110.7SYP, VIM, GFAP, S100B
29leucine448.7VIM, SYP, S100B, GFAP
30cyclic amp44 249.7GFAP, S100B, SYP, VIM
31ethanol44 50 24 1111.6GFAP, S100B, SYP
32s 100448.4SYP, GFAP, VIM, ACTC1, S100B
33reticulin448.4S100B, ACTC1, GFAP, VIM, SYP
34hematoxylin448.4S100B, SYP, ACTC1, GFAP, VIM
35formaldehyde44 249.4GFAP, VIM, ACTC1, SYP, S100B
36glycogen44 249.4S100B, VIM, ACTC1, SYP, GFAP
37paraffin448.4SYP, ACTC1, VIM, GFAP, S100B
38creatinine448.4S100B, SYP, VIM, GFAP, ACTC1
39progesterone44 28 61 24 1112.4GFAP, ACTC1, SYP, S100B, VIM
40testosterone44 61 24 1111.4ACTC1, VIM, GFAP, SYP, S100B
41dexamethasone44 50 28 1111.4VIM, GFAP, S100B, SYP, ACTC1
42vegf448.4GFAP, S100B, SYP, ACTC1, VIM
43glutamine448.4S100B, VIM, GFAP, IDH1, SYP
44estrogen448.4SYP, GFAP, ACTC1, S100B, VIM
45retinoic acid44 249.4SYP, ACTC1, VIM, GFAP, S100B
46cysteine448.4VIM, GFAP, SYP, S100B
47glutamate448.3SYP, VIM, IDH1, GFAP, S100B
48tyrosine447.9S100B, SYP, ACTC1, GFAP, PTPRJ
49serine447.8PTPRJ, VIM, SYP, S100B, GFAP
50calcium44 50 24 1110.6IDH1, PTPRJ, ACTC1, GFAP, SYP, S100B

GO Terms for genes affiliated with Angiocentric Glioma

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Cellular components related to Angiocentric Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.5VIM, IDH1
2intermediate filamentGO:0058829.0VIM, GFAP
3extracellular vesicular exosomeGO:0700628.2ACTC1, VIM, PTPRJ, IDH1

Biological processes related to Angiocentric Glioma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.6VIM, ACTC1
2regulation of neuronal synaptic plasticityGO:0481689.5SYP, S100B
3Bergmann glial cell differentiationGO:0600209.5GFAP, VIM
4astrocyte developmentGO:0140029.4VIM, GFAP
5intermediate filament organizationGO:0451099.4GFAP, VIM
6long-term synaptic potentiationGO:0602919.2S100B, GFAP
7negative regulation of neuron projection developmentGO:0109779.0GFAP, VIM

Molecular functions related to Angiocentric Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3VIM, GFAP
2identical protein bindingGO:0428028.7S100B, SYP, VIM

Products for genes affiliated with Angiocentric Glioma

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Sources for Angiocentric Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet