MCID: ANG050
MIFTS: 31

Angiocentric Glioma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Angiocentric Glioma

MalaCards integrated aliases for Angiocentric Glioma:

Name: Angiocentric Glioma 55 69

Characteristics:

Orphanet epidemiological data:

55
angiocentric glioma
Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Orphanet 55 ORPHA251671
UMLS via Orphanet 70 C2363903
ICD10 via Orphanet 33 C71.9
UMLS 69 C2363903

Summaries for Angiocentric Glioma

MalaCards based summary : Angiocentric Glioma is related to pilomyxoid astrocytoma and oligodendroglioma. An important gene associated with Angiocentric Glioma is QKI (QKI, KH Domain Containing RNA Binding), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Cell adhesion_Cadherin-mediated cell adhesion. Affiliated tissues include brain, temporal lobe and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Angiocentric Glioma

Diseases related to Angiocentric Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 pilomyxoid astrocytoma 30.0 GFAP SYP
2 oligodendroglioma 29.6 GFAP IDH1 SYP
3 dysembryoplastic neuroepithelial tumor 29.1 GFAP IDH1 S100B SYP
4 ependymoma 28.9 GFAP S100B SYP VIM
5 anaplastic ependymoma 28.6 GFAP S100B SYP VIM
6 astrocytoma 28.4 GFAP IDH1 S100B SYP VIM
7 glioma 10.7
8 anaplastic ganglioglioma 10.3 ACTC1 GFAP
9 mixed glioma 10.3 GFAP IDH1
10 epilepsy 10.3
11 fibrillary astrocytoma 10.3 GFAP IDH1
12 gliomatosis cerebri 10.3 GFAP IDH1
13 malignant giant cell tumor of soft parts 10.3 ACTC1 S100B
14 spinal cord astrocytoma 10.3 GFAP IDH1
15 malignant giant cell tumor 10.3 ACTC1 S100B
16 myopericytoma 10.3 ACTC1 S100B
17 intracranial cysts 10.2 GFAP S100B
18 necrotizing sialometaplasia 10.2 ACTC1 GFAP
19 gemistocytic astrocytoma 10.2 GFAP S100B
20 chordoid glioma 10.2 GFAP S100B
21 desmoplastic infantile ganglioglioma 10.2 GFAP SYP
22 lung combined type small cell carcinoma 10.2 GFAP SYP
23 cellular ependymoma 10.2 GFAP SYP
24 gangliocytoma 10.2 GFAP SYP
25 glycogen-rich clear cell breast carcinoma 10.1 ACTC1 SYP
26 central nervous system primitive neuroectodermal neoplasm 10.1 GFAP SYP
27 subependymal glioma 10.1 GFAP SYP
28 chiari malformation 10.1 GFAP SYP
29 cerebral neuroblastoma 10.1 GFAP SYP
30 benign ependymoma 10.1 GFAP SYP
31 cerebral ventricle cancer 10.1 GFAP SYP
32 cerebrum cancer 10.1 GFAP SYP
33 pineal gland cancer 10.1 GFAP SYP
34 traumatic brain injury 10.1 GFAP S100B
35 subependymoma 10.1 GFAP SYP
36 obstructive hydrocephalus 10.1 GFAP SYP
37 supratentorial cancer 10.1 GFAP SYP
38 horseshoe kidney 10.1 ACTC1 SYP
39 pineoblastoma 10.1 GFAP SYP
40 mixed type thymoma 10.1 S100B SYP
41 tanycytic ependymoma 10.1 GFAP SYP
42 hypoganglionosis 10.1 S100B SYP
43 central neurocytoma 10.1 GFAP SYP
44 breast papillary carcinoma 10.1 IDH1 SYP
45 supratentorial primitive neuroectodermal tumor 10.1 S100B SYP
46 atypical teratoid rhabdoid tumor 10.1 GFAP SYP
47 cystic teratoma 10.1 GFAP SYP
48 lymphangiectasis 10.1 ACTC1 VIM
49 glomangiomyoma 10.1 ACTC1 VIM
50 angiolipoma 10.0 ACTC1 VIM

Graphical network of the top 20 diseases related to Angiocentric Glioma:



Diseases related to Angiocentric Glioma

Symptoms & Phenotypes for Angiocentric Glioma

GenomeRNAi Phenotypes related to Angiocentric Glioma according to GeneCards Suite gene sharing:

25 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.66 MYB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.66 ACTC1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.66 MYB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.66 MYB
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.66 ACTC1 MYB
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.66 IDH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.66 IDH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.66 IDH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.66 ACTC1 IDH1 MYB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.66 MYB
11 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.66 MYB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.66 MYB
13 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.66 IDH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.66 MYB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.66 ACTC1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.66 IDH1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.66 IDH1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.66 MYB
19 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.66 MYB

MGI Mouse Phenotypes related to Angiocentric Glioma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 ACTC1 GFAP MYB PTPRJ QKI VIM
2 normal MP:0002873 9.1 ACTC1 GFAP MYB PTPRJ S100B SYP

Drugs & Therapeutics for Angiocentric Glioma

Search Clinical Trials , NIH Clinical Center for Angiocentric Glioma

Genetic Tests for Angiocentric Glioma

Anatomical Context for Angiocentric Glioma

MalaCards organs/tissues related to Angiocentric Glioma:

38
Brain, Temporal Lobe, Cortex

Publications for Angiocentric Glioma

Articles related to Angiocentric Glioma:

(show all 43)
# Title Authors Year
1
Brainstem angiocentric glioma: report of 2 cases. ( 28753090 )
2017
2
Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. ( 28776091 )
2017
3
Angiocentric Glioma in an Elderly Patient: Case Report and Review of the Literature. ( 27756673 )
2017
4
Angiocentric glioma transformed into anaplastic ependymoma: Review of the evidence for malignant potential. ( 27742374 )
2016
5
MYB-QKI Fusions Drive Angiocentric Glioma through Multiple Mechanisms. ( 26869254 )
2016
6
Angiocentric glioma from a perspective of A-B-C classification of epilepsy associated tumors. ( 27179220 )
2016
7
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. ( 26829751 )
2016
8
Angiocentric glioma of hippocampus-report of a rare intractable epilepsy-related tumor. ( 26954821 )
2016
9
"Unusual brain stone": heavily calcified primary neoplasm with some features suggestive of angiocentric glioma. ( 26024003 )
2015
10
Cystoid angiocentric glioma: A case report and literature review. ( 26629293 )
2015
11
MR Spectroscopic Profile of an Angiocentric Glioma. ( 26504061 )
2015
12
Angiocentric Glioma: The Infiltrative Glioma with Ependymal Differentiation. ( 24913299 )
2014
13
Well-differentiated pediatric glial neoplasms with features of oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumors: a morphological diagnostic challenge. ( 24448703 )
2014
14
Angiocentric glioma: a rare intractable epilepsy-related tumour in children. ( 25310736 )
2014
15
Intractable epilepsy due to angiocentric glioma: A case report and minireview. ( 24348765 )
2014
16
Angiocentric glioma: a treatable cause of epilepsy: report of a rare case. ( 25591686 )
2014
17
Angiocentric glioma: A report of nine new cases, including four with atypical histological features. ( 24861831 )
2014
18
Angiocentric glioma, a recently added WHO grade-I tumor. ( 27330646 )
2013
19
Angiocentric glioma: clinical, morphological, immunohistochemical and molecular features in three pediatric cases. ( 23073165 )
2013
20
Angiocentric glioma. ( 24116979 )
2013
21
The treatment of angiocentric glioma: case report and literature review. ( 23596378 )
2013
22
Isocitrate dehydrogenase 1 R132H mutation is not detected in angiocentric glioma. ( 22445362 )
2012
23
Angiocentric glioma in a 4-year-old boy: imaging characteristics and review of the literature. ( 22226445 )
2012
24
Adult-onset angiocentric glioma of epithelioid cell-predominant type of the mesial temporal lobe suggestive of a rare but distinct clinicopathological subset within a spectrum of angiocentric cortical ependymal tumors. ( 22151480 )
2012
25
Refractory temporal lobe epilepsy caused by angiocentric glioma complicated with focal cortical dysplasia: a surgical case series. ( 23065092 )
2012
26
The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma. ( 21892765 )
2012
27
Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature. ( 23378871 )
2012
28
Angiocentric glioma: a clinicopathologic review of 5 tumors with identification of associated cortical dysplasia. ( 21809996 )
2011
29
Angiocentric glioma with high proliferative index: case report and review of the literature. ( 22075509 )
2011
30
Angiocentric glioma and surrounding cortical dysplasia manifesting as intractable frontal lobe epilepsy--case report. ( 21785249 )
2011
31
A case of angiocentric glioma with unusual clinical and radiological features. ( 21887397 )
2011
32
Paroxysmal ictal phonemes in a patient with angiocentric glioma. ( 20160231 )
2010
33
Angiocentric glioma with rich blood supply. ( 20399664 )
2010
34
Angiocentric glioma: a case report and review of the literature. ( 19941376 )
2010
35
Angiocentric glioma-like tumor of the midbrain. ( 20110754 )
2009
36
Angiocentric glioma: a case series. ( 19338465 )
2009
37
Angiocentric glioma-induced seizures in a 2-year-old child. ( 19304961 )
2009
38
Angiocentric glioma: presentation of two cases with dissimilar histology. ( 19130736 )
2008
39
Cortical ependymoma or monomorphous angiocentric glioma? ( 18021197 )
2008
40
Brain surface spindle cell glioma in a patient with medically intractable partial epilepsy: a variant of monomorphous angiocentric glioma? ( 18179412 )
2008
41
Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. ( 17598825 )
2007
42
Angiocentric glioma: report of clinico-pathologic and genetic findings in 8 cases. ( 18059228 )
2007
43
Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. ( 16215459 )
2005

Variations for Angiocentric Glioma

Expression for Angiocentric Glioma

Search GEO for disease gene expression data for Angiocentric Glioma.

Pathways for Angiocentric Glioma

Pathways related to Angiocentric Glioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 GFAP S100B SYP VIM
2 10.56 ACTC1 PTPRJ

GO Terms for Angiocentric Glioma

Biological processes related to Angiocentric Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.46 GFAP S100B
2 muscle filament sliding GO:0030049 9.43 ACTC1 VIM
3 positive regulation of collagen biosynthetic process GO:0032967 9.4 MYB VIM
4 regulation of neuronal synaptic plasticity GO:0048168 9.37 S100B SYP
5 astrocyte development GO:0014002 9.32 GFAP VIM
6 intermediate filament organization GO:0045109 9.26 GFAP VIM
7 positive regulation of glial cell proliferation GO:0060252 9.16 GFAP MYB
8 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
9 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Angiocentric Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 GFAP IDH1 S100B SYP VIM

Sources for Angiocentric Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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