MCID: ANG011
MIFTS: 54

Angiodysplasia malady

Cardiovascular diseases, Gastrointestinal diseases categories

Summaries for Angiodysplasia

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Wikipedia:64 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards based summary: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to von willebrand's disease and arteriovenous malformation. An important gene associated with Angiodysplasia is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are Id Signaling Pathway and TGF Beta Signaling Pathway. The compounds gelofusine and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related mouse phenotypes are digestive/alimentary and respiratory system.

Disease Ontology:9 A vascular disease that is characterized as a small vascular malformation of the gut.

Aliases & Classifications for Angiodysplasia

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Angiodysplasia, Aliases & Descriptions:

Name: Angiodysplasia 9 11 44 61
 
Angiodysplasia of Stomach and Duodenum with Hemorrhage 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:2494
SNOMED-CT56 71072006
MeSH34 D016888

Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1von willebrand's disease31.2VWF, F3
2arteriovenous malformation30.9ACVRL1
3glucagonoma30.2SST, SCT
4thrombocytosis30.1F3, VWF
5deficiency anemia29.9F3, ENG, VWF
6vascular disease29.9VWF, VEGFA, F3
7liver cirrhosis29.8SST, F3, SCT
8adenocarcinoma29.6SST, ENG, VEGFA, SCT
9central retinal vein occlusion10.5VEGFA
10dumping syndrome10.4SST
11diabetic macular edema10.4VEGFA
12factor xi deficiency10.4F3
13intracranial hemorrhage in brain cerebrovascular malformations10.4ENG, ACVRL1
14telangiectasis10.3ENG, ACVRL1
15hypertension10.3
16telangiectasia, hereditary hemorrhagic, type 510.3ACVRL1, ENG
17vascular cancer10.3VEGFA, ENG
18duodenitis10.3
19hyperinsulinemic hypoglycemia10.2SST, SCT
20connective tissue disease10.2VWF, F3
21vipoma10.2SST, SCT
22hemarthrosis10.2VWF, F3
23zollinger-ellison syndrome10.2SCT, SST
24steatorrhea10.2SST, SCT
25intracranial thrombosis10.2VWF, F3
26hereditary hemorrhagic telangiectasia10.2
27bernard-soulier syndrome10.2
28aortic valve disease10.2
29aortic valve stenosis10.2
30blood platelet disease10.2VWF, F3
31factor xii deficiency10.2F3, VWF
32atrophic gastritis10.2SCT, SST
33hemorrhagic disease10.2VWF, F3
34duodenal ulcer10.2SCT, SST
35peptic ulcer disease10.2SCT, SST
36afibrinogenemia10.2F3, VWF
37factor viii deficiency10.2VWF, F3
38gastrinoma10.2SST, SCT
39wermer syndrome10.2SST, SCT
40glanzmann's thrombasthenia10.2F3, VWF
41antiphospholipid syndrome10.2VWF, F3
42meckel's diverticulum10.2
43angiodysplasia of intestine10.2
44factor vii deficiency10.2SST, VEGFA
45bone marrow cancer10.2ENG, VWF
46proliferative diabetic retinopathy10.1VEGFA, SST
47hemolytic anemia10.1VWF, F3
48peripheral vascular disease10.1VWF, SERPINE1
49hellp syndrome10.1SERPINE1, VWF
50acute pancreatitis10.1SST, SCT

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Symptoms for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Drug clinical trials:

Search ClinicalTrials for Angiodysplasia

Search NIH Clinical Center for Angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

32
Colon, Small intestine, Liver, Lung, Endothelial, Bone, Lymph node, Kidney, Tongue, Appendix

Animal Models for Angiodysplasia or affiliated genes

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MGI Mouse Phenotypes related to Angiodysplasia:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6ACVRL1, SST, VEGFA, VWF
2MP:00053888.4VEGFA, SERPINE1, ACVRL1, ENG
3MP:00053698.3VEGFA, F3, ACVRL1, ENG
4MP:00028738.2VEGFA, F3, SST, ACVRL1, ENG
5MP:00053857.6VWF, VEGFA, SERPINE1, F3, ACVRL1, ENG
6MP:00053877.6SST, F3, SERPINE1, VEGFA, VWF
7MP:00053977.6VWF, VEGFA, SERPINE1, F3, ACVRL1, ENG
8MP:00107687.4VWF, VEGFA, SERPINE1, F3, ACVRL1, ENG
9MP:00036317.4VWF, VEGFA, SCT, F3, SST, ACVRL1
10MP:00053787.4VEGFA, SERPINE1, F3, SST, ACVRL1, ENG
11MP:00053766.6ENG, VWF, VEGFA, SCT, SERPINE1, F3

Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50)    (show all 407)
idTitleAuthorsYear
1
Angiodysplasia in patient with chronic kidney disease. (23374531)
2013
2
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (23661527)
2013
3
Clinical genetics in endoscopy: a two-question diagnosis in a patient with gastrointestinal angiodysplasia. (23362958)
2013
4
Role of vascular endothelial growth factor in angiodysplasia: an interventional study with thalidomide. (22098296)
2012
5
Successful treatment of bleeding gastro-intestinal angiodysplasia in hereditary haemorrhagic telangiectasia with thalidomide. (22674103)
2011
6
Angiodysplasia of the gallbladder. (22096745)
2011
7
Von Willebrand disease, angiodysplasia and atorvastatin. (19995387)
2010
8
Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association. (19216082)
2009
9
The mechanisms of thalidomide in treatment of angiodysplasia due to hypoxia]. (19576118)
2009
10
Diffuse colorectal angiodysplasia misdiagnosed preoperatively as ulcerative colitis in a child: report of a case. (18668317)
2008
11
Von Willebrand disease and angiodysplasia responding to atorvastatin. (18510690)
2008
12
A hypervascular pseudotumor in the liver with angiodysplasia in the center of the lesion: a new entity or a variant of focal nodular hyperplasia? (17652535)
2007
13
Long-term efficacy of octreotide in the prevention of recurrent bleeding from gastrointestinal angiodysplasia. (17311647)
2007
14
Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. (17024322)
2006
15
Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management. (16020106)
2005
16
Role of hemoclips in a patient with cecal angiodysplasia at high risk of recurrent bleeding from antithrombotic therapy to maintain coronary stent patency: a case report. (16111979)
2005
17
Endoscopic detachable mini-loop ligation for treatment of gastroduodenal angiodysplasia: case study of 11 patients with long-term follow-up. (14997147)
2004
18
Angiodysplasia as a cause of gastrointestinal bleeding in childhood. (14747971)
2004
19
Colonic polypoid angiodysplasia. (12838229)
2003
20
Aortic stenosis and angiodysplasia in the elderly: common things occur commonly? (17670112)
2003
21
Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy. (12889571)
2003
22
Pedunculated angiodysplasia of the colon successfully treated with endoscopy: a new type of angiodysplasia. (12665782)
2003
23
Gastrointestinal angiodysplasia and aortic stenosis. (12226167)
2002
24
Selective angiographic catheterisation for jejunal angiodysplasia. (11222835)
2001
25
Angiodysplasia with osteohypertrophy affecting the oromaxillofacial area: clinical findings. (11572256)
2001
26
Migrating site of bleeding in a right colon demonstrating angio-dysplasia following a segmental resection of the colon. A unique variant of angiodysplasia. (11124566)
2000
27
Increased plasma vascular endothelial growth factor levels in patients with angiodysplasia. (10971796)
2000
28
Multiple jejunal angiodysplasia detected by enema-helical CT. (11124471)
2000
29
Accuracy of helical computed tomographic angiography for the diagnosis of colonic angiodysplasia. (10930363)
2000
30
Type 2B von Willebrand's disease and angiodysplasia. (10595657)
1999
31
Transjugular intrahepatic portosystemic shunt for bleeding angiodysplasia-like lesions in portal-hypertensive colopathy. (9649472)
1998
32
Is there a role for parathormone in the pathogenesis of colonic angiodysplasia? (9568887)
1998
33
Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia. (8898427)
1996
34
Angiodysplasia and lower gastrointestinal tract bleeding in elderly patients. (7717788)
1995
35
Small bowel angiodysplasia: usefulness of peroperative enteroscopy. (8513166)
1993
36
Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link? (1351610)
1992
37
Catheter-guided intraoperative localization of a jejunal angiodysplasia using the Tracker-18 coaxial catheter system: case report. (1756554)
1991
38
Hormonal therapy for bleeding from angiodysplasia: chronic renal failure, et al?? (2252035)
1990
39
A rare case of angiodysplasia: penetration of inguinal lymph nodes by large superficial leg veins. Report of five cases. (2114699)
1990
40
Angiodysplasia: current concepts. (3054852)
1988
41
Angiodysplasia in transposed colon. (3260769)
1988
42
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
43
Angiodysplasia in a colonic polyp. (3706089)
1986
44
Aortic stenosis associated with angiodysplasia. (2870037)
1986
45
Renal failure and angiodysplasia of the colon. (3873889)
1985
46
Acquired angiodysplasia. (6606356)
1983
47
Plain radiographic, nuclear medicine and angiographic observations of hepatogenic pulmonary angiodysplasia. (6223268)
1983
48
Angiodysplasia. (6118730)
1981
49
Congenital angiodysplasia with skeletal affection. (7368842)
1980
50
Gastrointestinal bleeding, angiodysplasia of the colon and acquired von Willebrand's disease. (6968610)
1980

Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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Expression patterns in normal tissues for genes affiliated with Angiodysplasia

Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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Compounds for genes affiliated with Angiodysplasia

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Compounds related to Angiodysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1gelofusine4410.0SST, VWF
2taurodeoxycholate449.9SST, SCT
3lafutidine449.9SCT, SST
4loxiglumide449.9SST, SCT
5tinzaparin44 1210.8F3, VWF
6hydroxyethyl starch449.7F3, VWF
7ppack449.7F3, VWF
8tirofiban44 1210.6F3, VWF
9prostaglandin j2449.5VEGFA, SERPINE1
10oxyntomodulin44 6010.5SST, SCT
1111-dehydrothromboxane b2449.5SERPINE1, VWF
12anisodamine449.5F3, SERPINE1
13hyaluronic acid44 2510.5VWF, ENG, VEGFA
14quinapril44 50 1211.4VWF, SERPINE1
15thyroxine44 2510.4SCT, VWF, SST
16octreotide44 60 29 1212.4SCT, VEGFA, SST
17tgf beta1449.2SERPINE1, ENG, ACVRL1
18phosphatidylserine44 29 1211.2F3, ENG, VWF
19perindopril44 50 1211.2VWF, VEGFA, SERPINE1
20ristocetin449.1VWF, F3
21c-peptide449.1SERPINE1, SCT, SST
22tranexamic acid44 1210.1F3, SERPINE1, VWF
23oligonucleotide449.1VWF, ENG, ACVRL1, SCT
24sodium nitroprusside449.1VWF, SERPINE1, SST
25desmopressin44 60 29 1212.1SERPINE1, F3, VWF
26hirudin449.1SERPINE1, F3, VWF
27atorvastatin44 50 29 25 1213.1VWF, VEGFA, SERPINE1
28dipyridamole44 60 29 1212.0VWF, SERPINE1, F3
29n(g)-nitro-l-arginine methyl ester449.0SERPINE1, F3
30kininogen449.0SERPINE1, F3, VWF
31aprotinin44 1210.0VWF, SERPINE1, F3
32fluoxetine44 50 29 1212.0SCT, F3, SERPINE1
33homocysteine44 2510.0F3, SERPINE1, VWF
34epsilon aminocaproic acid448.9F3, SERPINE1
35epinephrine44 25 1210.9F3, SCT, VWF, SST
36matrigel448.8ENG, VWF, SERPINE1, VEGFA
37isoproterenol44 129.7SCT, SERPINE1, VWF, SST
38aspirin44 50 29 2511.7F3, VWF, SERPINE1
39adenylate448.6SERPINE1, SCT, VWF, SST
40simvastatin44 50 60 29 25 1213.5VEGFA, VWF, SERPINE1, F3
41prostacyclin448.5F3, SERPINE1, VWF, VEGFA
42aspartate448.5VWF, SCT, SERPINE1, F3
43testosterone44 60 25 1211.5SCT, SERPINE1, SST, VWF
44heparin44 29 25 1211.4VWF, F3, SERPINE1, VEGFA
45cycloheximide448.3F3, SST, SERPINE1, VEGFA
46dexamethasone44 50 29 1211.3VEGFA, SST, ENG, VWF, SERPINE1
47retinoic acid44 259.0F3, SERPINE1, SCT, SST, VWF
48cyclophosphamide44 50 1210.0SERPINE1, VWF, F3, VEGFA, SST
49serine447.9ACVRL1, F3, SERPINE1, SCT, VWF, ENG
50vegf447.3SST, VWF, VEGFA, SERPINE1, F3, ACVRL1

GO Terms for genes affiliated with Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.8SERPINE1, VEGFA, VWF
2extracellular matrixGO:0310128.6F3, SERPINE1, VWF
3cell surfaceGO:0099868.6ENG, ACVRL1, F3, VEGFA
4extracellular spaceGO:0056157.5VEGFA, SERPINE1, F3, SST, ENG
5extracellular regionGO:0055767.4VWF, VEGFA, SCT, SERPINE1, SST

Biological processes related to Angiodysplasia according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of BMP signaling pathwayGO:0305139.9ACVRL1, ENG
2negative regulation of endothelial cell proliferationGO:0019379.8ENG, ACVRL1
3positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.8ENG, ACVRL1
4BMP signaling pathwayGO:0305099.8ENG, ACVRL1
5artery morphogenesisGO:0488449.7ENG, VEGFA
6chronological cell agingGO:0013009.6ENG, SERPINE1
7positive regulation of positive chemotaxisGO:0509279.6F3, VEGFA
8patterning of blood vesselsGO:0015699.5VEGFA, ENG
9positive regulation of endothelial cell proliferationGO:0019389.3ACVRL1, F3, VEGFA
10vasculogenesisGO:0015709.3ENG, VEGFA
11negative regulation of cell migrationGO:0303369.2SERPINE1, ACVRL1, ENG
12transforming growth factor beta receptor signaling pathwayGO:0071799.2SERPINE1, ACVRL1, ENG
13platelet degranulationGO:0025769.0SERPINE1, VEGFA, VWF
14angiogenesisGO:0015259.0ACVRL1, SERPINE1, VEGFA
15platelet activationGO:0301688.9VWF, VEGFA, SERPINE1
16positive regulation of angiogenesisGO:0457668.8VEGFA, SERPINE1, F3
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.6VEGFA, SERPINE1, ACVRL1, ENG
18blood coagulationGO:0075968.4F3, SERPINE1, VEGFA, VWF

Molecular functions related to Angiodysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:0504319.8ENG, ACVRL1
2activin bindingGO:0481859.7ENG, ACVRL1
3transforming growth factor beta-activated receptor activityGO:0050249.5ENG, ACVRL1
4protease bindingGO:0020208.6F3, SERPINE1, VWF

Products for genes affiliated with Angiodysplasia

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Sources for Angiodysplasia

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4CDC
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26ICD10
27ICD10 via Orphanet
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29IUPHAR
30KEGG
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57SNOMED-CT via Orphanet
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