Angiodysplasia disease: drugs, articles, genes, clinical trials

Summaries for Angiodysplasia

Sources:
⁴⁴Wikipedia, ²²MalaCards
See all sources

Export this MalaCard

Wikipedia: In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a...⁴⁴ more...

MalaCards: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to von willebrand's disease and glucagonoma. An important gene associated with Angiodysplasia is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are Complement and coagulation cascades and Blood Coagulation Signaling Pathways. The compounds aprotinin and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include colon, and related mouse phenotypes are hematopoietic system and normal.

Aliases & Descriptions for Angiodysplasia

about this section

Sources:
⁶Disease Ontology, ⁸DISEASES, ³²Novoseek , ⁴³UMLS, ²⁴MeSH, ⁴⁰SNOMED-CT
See all sources

Aliases & Descriptions:

angiodysplasia ⁶ ⁸ ³² ⁴³

angiodysplasia of stomach and duodenum with hemorrhage ⁶

External Ids:

MeSH²⁴ D016888

SNOMED-CT⁴⁰ 71072006

UMLS⁴³ C0085411, C0156091

Related Diseases for Angiodysplasia

about this section

Sources:
¹³GeneCards, ¹⁴GeneDecks
See all sources

Diseases related to angiodysplasia by text searches and GeneDecks gene sharing:

(show top 50) (show all 257)

id	Related Disease	Score	Top Affiliating Genes
1	von willebrand's disease	28.0	VWF, F3
2	glucagonoma	27.9	SCT, SST
3	hereditary hemorrhagic telangiectasia type 2	13.3	ENG, ACVRL1
4	hereditary hemorrhagic telangiectasia	13.3	ENG, ACVRL1
5	arteriovenous malformation	13.3	ENG, ACVRL1
6	telangiectasis	13.3	ENG, ACVRL1
7	hyperinsulinemic hypoglycemia	13.1	SCT, SST
8	dumping syndrome	13.0	SCT, SST
9	choledochal cyst	13.0	SCT, SST
10	classic kaposi sarcoma	13.0	VWF, VEGFA
11	vipoma	13.0	SCT, SST
12	acquired von willebrand syndrome	13.0	VWF, F3
13	hemarthrosis	13.0	VWF, F3
14	zollinger-ellison syndrome	13.0	SCT, SST
15	intracranial thrombosis	13.0	VWF, F3
16	blood platelet disease	13.0	VWF, F3
17	arterial occlusive disease	13.0	VWF, F3
18	atrophic gastritis	13.0	SCT, SST
19	gastrointestinal neuroendocrine tumor	13.0	VEGFA, SST
20	factor xi deficiency	13.0	VWF, F3
21	steatorrhea	13.0	SCT, SST
22	collagen disease	13.0	VWF, VEGFA
23	factor xii deficiency	13.0	VWF, F3
24	hypertensive nephropathy	13.0	VEGFA, SST
25	critical limb ischemia	13.0	VWF, VEGFA
26	factor viii deficiency	12.9	VWF, F3
27	afibrinogenemia	12.9	VWF, F3
28	hemophilia b	12.9	VWF, F3
29	diabetic macular edema	12.9	VEGFA, SST
30	growth hormone secreting pituitary adenoma	12.9	VEGFA, SST
31	wermer syndrome	12.9	SCT, SST
32	hemangioendothelioma	12.9	VWF, VEGFA
33	carcinoid syndrome	12.9	VEGFA, SST
34	crimean-congo hemorrhagic fever	12.8	VEGFA, F3
35	hemorrhagic disease	12.8	VWF, F3
36	peripheral vascular disease	12.8	VWF, SERPINE1
37	diabetic ketoacidosis	12.7	VWF, SST
38	thrombasthenia	12.7	VWF, F3
39	angiosarcoma	12.7	VWF, VEGFA, ENG
40	venous tributary occlusion of retina	12.7	VWF, SERPINE1
41	myeloproliferative disorder	12.7	VWF, VEGFA, ENG
42	castleman's disease	12.7	VEGFA, F3
43	diabetic angiopathy	12.7	VWF, SERPINE1
44	secondary hyperparathyroidism of renal origin	12.6	VWF, VEGFA, ACVRL1
45	polymyalgia rheumatica	12.6	VWF, VEGFA
46	connective tissue disease	12.6	VWF, F3, ACVRL1
47	carotid artery thrombosis	12.6	SERPINE1, F3
48	factor vii deficiency	12.6	VEGFA, SST
49	catastrophic antiphospholipid syndrome	12.6	SERPINE1, F3
50	polymyositis	12.5	VWF, VEGFA, SST

Graphical network of the top 20 diseases related to angiodysplasia:

Graphical network of diseases related to angiodysplasia

Clinical Features for Angiodysplasia

about this section

Drugs & Therapeutics for Angiodysplasia

about this section

Sources:
⁴CenterWatch, ²⁹NIH Clinical Center, ⁵ClinicalTrials, ⁴³UMLS, ²⁸NDF-RT
See all sources

Approved drugs:

Search CenterWatch for angiodysplasia

Drug clinical trials:

Search ClinicalTrials for angiodysplasia

Search NIH Clinical Center for angiodysplasia

Search CenterWatch for angiodysplasia

Genetic Tests for Angiodysplasia

about this section

Anatomical Context for Angiodysplasia

about this section

Sources:
²²MalaCards
See all sources

MalaCards organs/tissues related to angiodysplasia:

²²

Colon

Phenotypes for genes affiliated with Angiodysplasia

about this section

Sources:
²⁵MGI
See all sources

MGI Mouse Phenotypes related to angiodysplasia:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.8	ENG, ACVRL1
2	normal phenotype	MP:0002873	7.8	ACVRL1, SST, F3, ENG, VEGFA
3	nervous system phenotype	MP:0003631	7.5	ACVRL1, SST, F3, SCT, VEGFA, VWF
4	cardiovascular system phenotype	MP:0005385	7.4	ACVRL1, F3, ENG, VEGFA, SERPINE1, VWF
5	growth/size phenotype	MP:0005378	7.3	SERPINE1, VEGFA, ENG, F3, SST, ACVRL1
6	homeostasis/metabolism phenotype	MP:0005376	6.5	VWF, ACVRL1, SST, F3, ENG, SCT

Publications for genes affiliated with Angiodysplasia

about this section

Sources:
³⁵PubMed
See all sources

Articles related to angiodysplasia:

id	Title	Authors	Year	Affiliating Genes
1	Somatostatin analogues in the treatment of bleeding GI-angiodysplasias. (18397628)	Boesby L.... Kristensen L.O.	2008	SST
2	Increased plasma fibrinolytic activity in bleeding gastrointestinal angiodysplasia. (15674098)	Junquera F.... Malagelada J.R.	2005	SERPINE1
3	Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy. (12889571)	Blich M.... Edoute Y.	2003	SST
4	Immunohistochemical assessment of an asymptomatic glucagonoma in a patient with hypergastrinemia and marked antral angiodysplasia. (11277423)	Weitgasser R.... Hacker G.W.	2001	SCT
5	Increased expression of angiogenic factors in human colonic angiodysplasia. (10201485)	Junquera F.... Malagelada J.R.	1999	VEGFA
6	Idiopathic immune-mediated acquired von Willebrand's disease in a patient with angiodysplasia: demonstration of an unusual inhibitor causing a functional defect and rapid clearance of von Willebrand factor. (9929110)	Alhumood S.A.... Carter C.J.	1999	VWF, F3
7	Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia. (8898427)	Andersen M.R.... Aaseby J.	1996	SST

Genes related to Angiodysplasia

about this section

Sources:
¹³GeneCards
See all sources

Genes related to angiodysplasia according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	ACVRL1	activin A receptor type II-like 1	11.0
2	ENG	endoglin	11.0
3	VWF	von Willebrand factor	11.0	Publications
4	SCT	secretin	11.0	Publications
5	SST	somatostatin	11.0	Publications
6	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
7	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
8	VEGFA	vascular endothelial growth factor A	11.0	Publications

Expression for genes affiliated with Angiodysplasia

about this section

Sources:
¹BioGPS
See all sources

Expression patterns in normal tissues for genes affiliated with Angiodysplasia

Pathways for genes affiliated with Angiodysplasia

about this section

Sources:
²⁰KEGG, ³⁷R&D Systems
See all sources

Pathways related to angiodysplasia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Complement and coagulation cascades²⁰	8.6	VWF, SERPINE1, F3
2	Blood Coagulation Signaling Pathways³⁷	8.3	VWF, SERPINE1, F3

Compounds for genes affiliated with Angiodysplasia

about this section

Sources:
³²Novoseek , ⁹DrugBank, ¹⁸HMDB, ⁴²Tocris Bioscience, ³⁴PharmGKB
See all sources

Compounds related to angiodysplasia according to GeneDecks:

(show top 50) (show all 55)

id	Compound	Score	Top Affiliating Genes
1	aprotinin³² ⁹ ⁹	12.5	VWF
2	c-peptide³²	10.4	SCT
3	hyaluronic acid³² ¹⁸	11.4	ENG
4	aspartate³²	10.3	SCT
5	phosphatidylserine³² ⁹ ⁹	12.3	VWF
6	gelofusine³²	10.0	VWF, SST
7	isoproterenol³² ⁹ ⁹	11.9	SCT, SST
8	taurodeoxycholate³²	9.9	SCT, SST
9	sodium nitroprusside³²	9.9	VWF, SST
10	lafutidine³²	9.9	SCT, SST
11	loxiglumide³²	9.9	SST, SCT
12	tinzaparin³² ⁹ ⁹	11.8	F3, VWF
13	epinephrine³² ⁹ ¹⁸ ⁹	12.8	SCT, F3
14	hydroxyethyl starch³²	9.8	F3, VWF
15	ppack³²	9.8	VWF, F3
16	oxyntomodulin³² ⁴²	10.7	SST, SCT
17	tirofiban³² ⁹ ⁹	11.7	VWF, F3
18	11-dehydrothromboxane b2³²	9.6	SERPINE1, VWF
19	quinapril³² ⁹ ⁹	11.6	VWF, SERPINE1
20	prostaglandin j2³²	9.5	SERPINE1, VEGFA
21	ristocetin³²	9.5	VWF, F3
22	anisodamine³²	9.5	SERPINE1, F3
23	octreotide³² ⁴² ⁹ ⁹	12.4	SST, SCT, VEGFA
24	thyroxine³² ¹⁸	10.4	SST, SCT, VWF
25	ticlopidine³² ⁹ ⁹	11.3	F3, VWF
26	tgf beta1³²	9.2	SERPINE1, ENG, ACVRL1
27	epsilon aminocaproic acid³²	9.2	F3, SERPINE1
28	perindopril³² ³⁴ ⁹ ⁹	12.2	VWF, SERPINE1, VEGFA
29	atorvastatin³² ³⁴ ⁹ ¹⁸ ⁹	13.1	VWF, SERPINE1, VEGFA
30	tranexamic acid³² ⁹ ⁹	11.1	F3, SERPINE1, VWF
31	desmopressin³² ⁴² ⁹ ⁹	12.1	F3, SERPINE1, VWF
32	dipyridamole⁴² ³² ⁹ ⁹	12.0	VWF, SERPINE1, F3
33	kininogen³²	9.0	VWF, SERPINE1, F3
34	n(g)-nitro-l-arginine methyl ester³²	9.0	SERPINE1, F3
35	homocysteine³² ¹⁸	10.0	VWF, SERPINE1, F3
36	heparin³² ⁹ ¹⁸ ⁹	11.9	F3, SERPINE1, VWF
37	oligonucleotide³²	8.9	VWF, SCT, ENG, ACVRL1
38	matrigel³²	8.8	ENG, VEGFA, SERPINE1, VWF
39	aspirin³² ³⁴ ¹⁸	10.7	VWF, SERPINE1, F3
40	fucoidan³²	8.7	SERPINE1, F3
41	adenylate³²	8.6	VWF, SERPINE1, SCT, SST
42	simvastatin³² ³⁴ ⁴² ⁹ ¹⁸ ⁹	13.5	F3, VEGFA, SERPINE1, VWF
43	cyclophosphamide³² ³⁴ ⁹ ⁹	11.5	SST, F3, SERPINE1, VWF
44	prostacyclin³²	8.5	VWF, SERPINE1, VEGFA, F3
45	testosterone³² ⁹ ¹⁸ ⁹	11.4	VWF, SERPINE1, SCT, SST
46	dexamethasone³² ⁴² ³⁴ ⁹ ⁹	12.2	SST, ENG, VEGFA, SERPINE1, VWF
47	cycloheximide³²	8.2	SERPINE1, VEGFA, F3, SST
48	retinoic acid³² ⁴² ¹⁸	10.0	SST, F3, SCT, SERPINE1, VWF
49	serine³²	7.8	ACVRL1, F3, ENG, SCT, SERPINE1, VWF
50	vegf³²	7.3	VWF, SERPINE1, VEGFA, ENG, F3, SST

GO Terms for genes affiliated with Angiodysplasia

about this section

Sources:
¹²Gene Ontology
See all sources

Cellular components related to angiodysplasia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	8.7	VWF, SERPINE1, VEGFA
2	extracellular matrix	GO:031012	8.3	F3, SERPINE1, VWF
3	extracellular region	GO:005576	7.7	VWF, SERPINE1, VEGFA, SCT, SST
4	extracellular space	GO:005615	7.5	SERPINE1, VEGFA, ENG, F3, SST

Biological processes related to angiodysplasia according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of BMP signaling pathway	GO:030513	9.8	ACVRL1, ENG
2	negative regulation of endothelial cell proliferation	GO:001937	9.7	ENG, ACVRL1
3	chronological cell aging	GO:001300	9.6	SERPINE1, ENG
4	positive regulation of positive chemotaxis	GO:050927	9.5	F3, VEGFA
5	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	9.5	ENG, ACVRL1
6	positive regulation of endothelial cell proliferation	GO:001938	9.3	VEGFA, F3, ACVRL1
7	negative regulation of cell migration	GO:030336	9.2	SERPINE1, ENG, ACVRL1
8	transforming growth factor beta receptor signaling pathway	GO:007179	9.1	SERPINE1, ENG, ACVRL1
9	platelet degranulation	GO:002576	8.9	VWF, SERPINE1, VEGFA
10	angiogenesis	GO:001525	8.9	SERPINE1, VEGFA, ACVRL1
11	positive regulation of angiogenesis	GO:045766	8.7	F3, VEGFA, SERPINE1
12	platelet activation	GO:030168	8.7	VWF, SERPINE1, VEGFA
13	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	ACVRL1, ENG, VEGFA, SERPINE1
14	blood coagulation	GO:007596	8.2	F3, VEGFA, SERPINE1, VWF

Molecular functions related to angiodysplasia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transforming growth factor beta binding	GO:050431	9.8	ACVRL1, ENG
2	activin binding	GO:048185	9.7	ACVRL1, ENG
3	transforming growth factor beta-activated receptor activity	GO:005024	9.5	ENG, ACVRL1
4	cell surface binding	GO:043498	9.3	VEGFA, F3
5	protease binding	GO:002020	8.7	VWF, SERPINE1, F3