MCID: ANG011
MIFTS: 39

Angiodysplasia malady

Categories: Gastrointestinal diseases, Cardiovascular diseases

Aliases & Classifications for Angiodysplasia

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Aliases & Descriptions for Angiodysplasia:

Name: Angiodysplasia 10 47 12 36 65
Angiodysplasia of Stomach and Duodenum with Hemorrhage 10
 
Angiodysplasia of Colon 65

Classifications:



External Ids:

Disease Ontology10 DOID:2494
ICD9CM29 537.83
SNOMED-CT59 71072006
MeSH36 D016888
ICD1027 K55.2
UMLS65 C0085411, C0156091, C0267370

Summaries for Angiodysplasia

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Wikipedia:68 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards based summary: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to protein-energy malnutrition and thyroid cancer. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways are Id Signaling Pathway and HIF-1-alpha transcription factor network. Affiliated tissues include colon, breast and endothelial, and related mouse phenotypes are respiratory system and digestive/alimentary.

Disease Ontology:10 A vascular disease that is characterized as a small vascular malformation of the gut.

Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1protein-energy malnutrition30.0ACVRL1, VEGFA
2thyroid cancer29.9ACVRL1, VEGFA, VWF
3angiodysplasia of intestine12.3
4nevada syndrome11.3
5angioosteohypotrophic syndrome11.3
6lymphoma10.3
7refractory plasma cell neoplasm10.3VEGFA, VWF
8myoma10.3VEGFA, VWF
9liver lymphoma10.2VEGFA, VWF
10intraocular lymphoma10.2VEGFA, VWF
11neuropathy10.2
12breast cancer10.2
13b-cell lymphomas10.2
14leukemia10.2
15prostatitis10.2
16tendinopathy10.2VEGFA, VWF
17chronic venous insufficiency10.2VEGFA, VWF
18insulin-like growth factor i10.1
19hepatitis10.1
20pancreatitis10.1
21thyroiditis10.1
22endotheliitis10.1
23grayson-wilbrandt corneal dystrophy10.1ENG, VEGFA
24hidrotic ectodermal dysplasia 210.1ACVRL1, ENG
25colorectal cancer10.1
26brain injury10.1
27diffuse large b-cell lymphoma10.1
28severe combined immunodeficiency10.1
29traumatic brain injury10.1
30choroiditis10.1
31urethritis10.1
32neuroendocrine tumor10.1
33melanoma10.1
34cervicitis10.1
35adenocarcinoma10.1
36astrocytoma10.1
37tuberculosis10.1
38neuronitis10.1
39preeclampsia/eclampsia 110.1ENG, VEGFA
40cerebral atherosclerosis10.0ACVRL1, ENG
41central nervous system germinoma10.0SST, VWF
42lethal congenital contractural syndrome 210.0SST, VEGFA
43pancreatic cystadenocarcinoma10.0SCT, SST
44glucose-6-phosphate translocase deficiency10.0SCT, SST
45dentin sensitivity10.0SCT, SST
46cholesterol ester storage disease10.0SCT, SST
47inhibited male orgasm10.0SCT, SST
48ampulla of vater neoplasm10.0SCT, SST
49lung cancer10.0
50prostate cancer10.0

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Symptoms for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 4, Phase 2, Phase 310217439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro
2Contraceptives, OralPhase 43734
3
Octreotideapproved, investigationalPhase 2, Phase 319883150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
 
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Ocphyl
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide acetate
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatin
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
4
Proton pump inhibitorsPhase 2, Phase 3958
Synonyms:
 
PPIs
5
SomatostatinPhase 2, Phase 315351110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
6Gastrointestinal AgentsPhase 2, Phase 36401
7Antineoplastic Agents, HormonalPhase 2, Phase 34256
8Immunologic FactorsPhase 2, Phase 118483
9Immunosuppressive AgentsPhase 2, Phase 110422
10Anti-Infective AgentsPhase 2, Phase 117220
11Angiogenesis InhibitorsPhase 2, Phase 13688
12Angiogenesis Modulating AgentsPhase 2, Phase 13611
13Anti-Bacterial AgentsPhase 2, Phase 19140
14
PomalidomideapprovedPhase 110919171-19-8
Synonyms:
 
Pomalyst
15Hemostatics1082
16ColaNutraceutical1768

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Capsule Endoscopy vs Standard of Care for Obscure Intestinal BleedingRecruitingNCT00694954Phase 4
2Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical TrialCompletedNCT01601639Phase 3
3Cyrotherapy vs. APC in GAVECompletedNCT00587405Phase 2, Phase 3
4Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Small Bowel AngiodysplasiasRecruitingNCT02384122Phase 2, Phase 3
5Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment FailureCompletedNCT02622906Phase 2
6Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular MalformationCompletedNCT00964496Phase 2
7Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal BleedingCompletedNCT00389935Phase 2
8Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related BleedingWithdrawnNCT02754960Phase 2
9Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I StudyNot yet recruitingNCT02287558Phase 1
10Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam CapsuleCompletedNCT01820182
11Study of Hemospray for Lower Gastrointestinal HemorrhageRecruitingNCT02099435
12Prophylactic Elective Clipping of Colonic DiverticulaRecruitingNCT02094456

Search NIH Clinical Center for Angiodysplasia


Cochrane evidence based reviews: angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

33
Colon, Breast, Endothelial, Bone, Prostate, Lung, Brain

Animal Models for Angiodysplasia or affiliated genes

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MGI Mouse Phenotypes related to Angiodysplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8ACVRL1, CADPS, ENG, VEGFA
2MP:00053818.4ACVRL1, SST, VEGFA, VWF
3MP:00036317.4ACVRL1, CADPS, ENG, SST, VEGFA, VWF
4MP:00107687.4ACVRL1, CADPS, ENG, SST, VEGFA, VWF
5MP:00053767.1ACVRL1, CADPS, ENG, SST, VEGFA, VWF

Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50)    (show all 422)
idTitleAuthorsYear
1
Republication: Two Premature Neonates of Congenital Syphilis with Severe Clinical Manifestations. (26543391)
2015
2
Rare detection of occult hepatitis B virus infection in children of mothers with positive hepatitis B surface antigen. (25383543)
2014
3
Adjunctive levetiracetam treatment in pediatric Lennox-Gastaut syndrome. (25266616)
2014
4
Decision tree analysis of traditional risk factors of carotid atherosclerosis and a cutpoint-based prevention strategy. (25398126)
2014
5
Pet Dog Ownership Decisions for Parents of Children With Autism Spectrum Disorder. (24183985)
2013
6
Role of female pelvic anatomy in infertility. (23197390)
2013
7
Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia. (22154022)
2012
8
Assembly factors as a new class of disease genes for mitochondrial complex I deficiency: cause, pathology and treatment options. (22036961)
2012
9
Breast implant related anaplastic large cell lymphoma presenting as late onset peri-implant effusion. (21840718)
2012
10
P16, c-erbB2 and Ki67 immunoexpression in urothelial carcinomas of the bladder. (21655657)
2011
11
Mild hyperkalemia and low eGFR a tedious recipe for cardiac disaster in the elderly: an unusual reversible cause of syncope and heart block. (22049311)
2011
12
HLA-DR6 association confers increased resistance to T. rubrum onychomycosis in Mexican Mestizos. (21091674)
2010
13
The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder. (19968708)
2010
14
The measurement of lysosomal phospholipase A2 activity in plasma. (20410020)
2010
15
Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer. (19111386)
2009
16
Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs. (19679477)
2009
17
Glutathione S-transferase theta 1 expressed in granulosa cells as a biomarker for oocyte quality in age-related infertility. (17919612)
2008
18
Gametocyte clearance in uncomplicated and severe Plasmodium falciparum malaria after artesunate-mefloquine treatment in Thailand. (18552540)
2008
19
Rigid interferon-alpha subtype responses of human plasmacytoid dendritic cells. (18937549)
2008
20
Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2L/TRAIL. (17462628)
2007
21
HLA-A and HLA-B distribution in Toto - a vanishing sub-Himalayan tribe of India. (16451204)
2006
22
BRCA2: breaks, mistakes and failed separations. (15823750)
2005
23
Intronic mutations in the L1CAM gene may cause X-linked hydrocephalus by aberrant splicing. (15108295)
2004
24
The lack of a clinical effect of cimetidine in the treatment of epidermodysplasia verruciformis. (15153919)
2004
25
Programmed cell death protein 4 (pdcd4): a novel target for antineoplastic therapy? (14630388)
2003
26
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. (12510191)
2003
27
Recommendations of the Deutschen Gesellschaft fA1r Rheumatologie on therapy of rheumatoid arthritis with the interleukin-1-receptor-antagonist Akakinra (KINERET)]. (12491134)
2002
28
Therapy in unilateral sirenomelia: report of one case. (11497371)
2001
29
Pseudocarcinomatous change in lymphomatoid papulosis and primary cutaneous CD30+ lymphoma: a clinicopathologic and immunohistochemical study of 6 patients. (11174381)
2001
30
Conformational dependence of collagenase (matrix metalloproteinase-1) up-regulation by elastin peptides in cultured fibroblasts. (11084020)
2001
31
Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. (11306702)
2001
32
Autonomic seizures versus syncope in 18q- deletion syndrome: a case report. (10961633)
2000
33
Interferon-alpha may exacerbate cryoblobulinemia-related ischemic manifestations: an adverse effect potentially related to its anti-angiogenic activity. (10323463)
1999
34
C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms. (9461517)
1998
35
Inhibition of bone resorption by 17beta-estradiol in human bone marrow cultures. (9491785)
1998
36
Bacterial resistances to toxic metal ions--a review. (8991852)
1996
37
Synthesis and contractile activities of cyclic thrombin receptor-derived peptide analogues with a Phe-Leu-Leu-Arg motif: importance of the Phe/Arg relative conformation and the primary amino group for activity. (8784457)
1996
38
Disseminated intravascular coagulation associated with granulocyte colony-stimulating factor therapy in a child with human immunodeficiency virus infection. (7538574)
1995
39
Atrial natriuretic peptide concentrations in children with pulmonary hypertension: correlation with hemodynamic measurements. (7838802)
1994
40
Endothelin-2 mRNA splice variants detected by RT-PCR in cultured human vascular smooth muscle and endothelial cells. (7509938)
1993
41
Iliac periosteal graft with vascular pedicle in the treatment of avascular necrosis of the femoral head. Experimental study and clinical application. (1291204)
1992
42
Vulvar intraepithelial neoplasia. A clinicopathologic study of 60 cases. (2177508)
1990
43
Laryngeal involvement in dermatitis herpetiformis. (2312825)
1990
44
Epidural haematoma and unilateral exophthalmos--a review. (2672704)
1989
45
Angiostrongyliasis cantonensis. (287448)
1979
46
Quadriplegia and cortical blindness in Hemophilus influenzae meningitis. (671161)
1978
47
Aphthous stomatitis as a featuring syndrome of emotional stress in dental treatment. (1076577)
1976
48
Functional changes during high output failure produced by daily hemorrhage in dogs with pulmonic stenosis. (13447182)
1957
49
Neurocirculatory asthenia. (15423039)
1950
50

Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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Pathways related to Angiodysplasia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5ACVRL1, VEGFA
29.5ENG, VEGFA

GO Terms for genes affiliated with Angiodysplasia

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Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1patterning of blood vesselsGO:00015699.9ENG, VEGFA
2artery morphogenesisGO:00488449.8ENG, VEGFA
3BMP signaling pathwayGO:00305099.8ACVRL1, ENG
4positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.8ACVRL1, ENG
5platelet degranulationGO:00025769.7VEGFA, VWF
6vasculogenesisGO:00015709.6ENG, VEGFA
7negative regulation of cell migrationGO:00303369.3ACVRL1, ENG
8angiogenesisGO:00015259.1ACVRL1, ENG, VEGFA
9positive regulation of angiogenesisGO:00457669.0ACVRL1, ENG, VEGFA

Sources for Angiodysplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet