MCID: ANG011
MIFTS: 48

Angiodysplasia malady

Gastrointestinal diseases category

Aliases & Classifications for Angiodysplasia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 33MeSH, 56SNOMED-CT, 25ICD10
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Aliases & Descriptions for Angiodysplasia:

Name: Angiodysplasia 8 10 44 61
Angiodysplasia of Stomach and Duodenum with Hemorrhage 8
 
Angiodysplasia of Colon 61


Classifications:



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Disease Ontology8 DOID:2494
MeSH33 D016888
SNOMED-CT56 71072006
ICD1025 K55.2

Summaries for Angiodysplasia

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Wikipedia:64 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards based summary: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to von willebrand's disease and arteriovenous malformation. An important gene associated with Angiodysplasia is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are Id Signaling Pathway and TGF Beta Signaling Pathway. The compounds gelofusine and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related mouse phenotypes are digestive/alimentary and respiratory system.

Disease Ontology:8 A vascular disease that is characterized as a small vascular malformation of the gut.

Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1von willebrand's disease31.2VWF, F3
2arteriovenous malformation30.9ACVRL1
3hereditary hemorrhagic telangiectasia30.8ACVRL1, ENG
4glucagonoma30.2SST, SCT
5thrombocytosis30.1F3, VWF
6deficiency anemia29.9F3, ENG, VWF
7vascular disease29.9VWF, VEGFA, F3
8liver cirrhosis29.8SST, F3, SCT
9adenocarcinoma29.6SST, ENG, VEGFA, SCT
10central retinal vein occlusion10.5VEGFA
11dumping syndrome10.4SST
12diabetic macular edema10.4VEGFA
13factor xi deficiency, autosomal recessive10.4F3
14factor viii deficiency10.4F3
15cerebral arteriovenous malformation10.4ENG, ACVRL1
16telangiectasis10.3ENG, ACVRL1
17duodenitis10.3
18vascular cancer10.3VEGFA, ENG
19hyperinsulinemic hypoglycemia, familial, 210.2SST, SCT
20angiodysplasia of intestine10.2
21connective tissue disease10.2VWF, F3
22vipoma10.2SST, SCT
23hemarthrosis10.2VWF, F3
24zollinger-ellison syndrome10.2SCT, SST
25steatorrhea10.2SST, SCT
26intracranial thrombosis10.2VWF, F3
27blood platelet disease10.2VWF, F3
28factor xii deficiency10.2F3, VWF
29atrophic gastritis10.2SCT, SST
30hemorrhagic disease10.2VWF, F3
31duodenal ulcer10.2SCT, SST
32peptic ulcer disease10.2SCT, SST
33afibrinogenemia10.2F3, VWF
34hemophilia a10.2VWF, F3
35gastrinoma10.2SST, SCT
36multiple endocrine neoplasia 110.2SST, SCT
37glanzmann thrombasthenia10.2F3, VWF
38meckel's diverticulum10.2
39antiphospholipid syndrome10.2VWF, F3
40factor vii deficiency10.1SST, VEGFA
41bone marrow cancer10.1ENG, VWF
42microvascular complications of diabetes 110.1VEGFA, SST
43hemolytic anemia10.1VWF, F3
44peripheral vascular disease10.1VWF, SERPINE1
45hellp syndrome10.1SERPINE1, VWF
46acute pancreatitis10.1SST, SCT
47renal fibrosis10.1SERPINE1, ENG
48brain disease10.1F3, VWF
49hemangioma10.1
50myelofibrosis10.1

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Symptoms for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Drug clinical trials:

Search ClinicalTrials for Angiodysplasia

Search NIH Clinical Center for Angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

31
Colon, Small intestine, Liver, Lung, Endothelial, Bone, Lymph node, Kidney, Tongue, Appendix

Animal Models for Angiodysplasia or affiliated genes

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MGI Mouse Phenotypes related to Angiodysplasia:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6SST, VEGFA, VWF, ACVRL1
2MP:00053888.4VEGFA, SERPINE1, ACVRL1, ENG
3MP:00053698.3ENG, ACVRL1, VEGFA, F3
4MP:00028738.2ACVRL1, SST, VEGFA, F3, ENG
5MP:00053857.6VWF, VEGFA, SERPINE1, F3, ENG, ACVRL1
6MP:00053877.6VWF, SERPINE1, F3, SST, VEGFA
7MP:00053977.6ENG, ACVRL1, F3, SERPINE1, VEGFA, VWF
8MP:00036317.4ACVRL1, SST, F3, SCT, ENG, VEGFA
9MP:00107687.4F3, SERPINE1, VEGFA, ENG, ACVRL1, VWF
10MP:00053787.4SST, SERPINE1, ENG, ACVRL1, F3, VEGFA
11MP:00053766.6SST, VWF, SCT, SERPINE1, F3, ENG

Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50)    (show all 410)
idTitleAuthorsYear
1
eComment. Doctor Jekyll and Mr Heyde: a vague association between angiodysplasia and aortic stenosis. (25417216)
2014
2
Angiodysplasia in patient with chronic kidney disease. (23374531)
2013
3
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (23661527)
2013
4
Clinical genetics in endoscopy: a two-question diagnosis in a patient with gastrointestinal angiodysplasia. (23362958)
2013
5
Role of vascular endothelial growth factor in angiodysplasia: an interventional study with thalidomide. (22098296)
2012
6
Successful treatment of bleeding gastro-intestinal angiodysplasia in hereditary haemorrhagic telangiectasia with thalidomide. (22674103)
2011
7
Angiodysplasia of the gallbladder. (22096745)
2011
8
Von Willebrand disease, angiodysplasia and atorvastatin. (19995387)
2010
9
Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association. (19216082)
2009
10
The mechanisms of thalidomide in treatment of angiodysplasia due to hypoxia]. (19576118)
2009
11
Von Willebrand disease and angiodysplasia responding to atorvastatin. (18510690)
2008
12
A hypervascular pseudotumor in the liver with angiodysplasia in the center of the lesion: a new entity or a variant of focal nodular hyperplasia? (17652535)
2007
13
Long-term efficacy of octreotide in the prevention of recurrent bleeding from gastrointestinal angiodysplasia. (17311647)
2007
14
Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. (17024322)
2006
15
Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management. (16020106)
2005
16
Pedunculated angiodysplasia of the colon treated with endoscopic resection: a case report. (16110853)
2005
17
Role of hemoclips in a patient with cecal angiodysplasia at high risk of recurrent bleeding from antithrombotic therapy to maintain coronary stent patency: a case report. (16111979)
2005
18
Endoscopic detachable mini-loop ligation for treatment of gastroduodenal angiodysplasia: case study of 11 patients with long-term follow-up. (14997147)
2004
19
Angiodysplasia as a cause of gastrointestinal bleeding in childhood. (14747971)
2004
20
Colonic polypoid angiodysplasia. (12838229)
2003
21
Aortic stenosis and angiodysplasia in the elderly: common things occur commonly? (17670112)
2003
22
Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy. (12889571)
2003
23
Pedunculated angiodysplasia of the colon successfully treated with endoscopy: a new type of angiodysplasia. (12665782)
2003
24
Gastrointestinal angiodysplasia and aortic stenosis. (12226167)
2002
25
Selective angiographic catheterisation for jejunal angiodysplasia. (11222835)
2001
26
Angiodysplasia with osteohypertrophy affecting the oromaxillofacial area: clinical findings. (11572256)
2001
27
Migrating site of bleeding in a right colon demonstrating angio-dysplasia following a segmental resection of the colon. A unique variant of angiodysplasia. (11124566)
2000
28
Increased plasma vascular endothelial growth factor levels in patients with angiodysplasia. (10971796)
2000
29
Multiple jejunal angiodysplasia detected by enema-helical CT. (11124471)
2000
30
Type 2B von Willebrand's disease and angiodysplasia. (10595657)
1999
31
Transjugular intrahepatic portosystemic shunt for bleeding angiodysplasia-like lesions in portal-hypertensive colopathy. (9649472)
1998
32
Is there a role for parathormone in the pathogenesis of colonic angiodysplasia? (9568887)
1998
33
Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia. (8898427)
1996
34
Angiodysplasia and lower gastrointestinal tract bleeding in elderly patients. (7717788)
1995
35
Small bowel angiodysplasia: usefulness of peroperative enteroscopy. (8513166)
1993
36
Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link? (1351610)
1992
37
Catheter-guided intraoperative localization of a jejunal angiodysplasia using the Tracker-18 coaxial catheter system: case report. (1756554)
1991
38
Hormonal therapy for bleeding from angiodysplasia: chronic renal failure, et al?? (2252035)
1990
39
A rare case of angiodysplasia: penetration of inguinal lymph nodes by large superficial leg veins. Report of five cases. (2114699)
1990
40
Angiodysplasia: current concepts. (3054852)
1988
41
Angiodysplasia in transposed colon. (3260769)
1988
42
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
43
Angiodysplasia in a colonic polyp. (3706089)
1986
44
Aortic stenosis associated with angiodysplasia. (2870037)
1986
45
Renal failure and angiodysplasia of the colon. (3873889)
1985
46
Acquired angiodysplasia. (6606356)
1983
47
Plain radiographic, nuclear medicine and angiographic observations of hepatogenic pulmonary angiodysplasia. (6223268)
1983
48
Angiodysplasia. (6118730)
1981
49
Congenital angiodysplasia with skeletal affection. (7368842)
1980
50
Gastrointestinal bleeding, angiodysplasia of the colon and acquired von Willebrand's disease. (6968610)
1980

Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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Compounds for genes affiliated with Angiodysplasia

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Compounds related to Angiodysplasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1gelofusine4410.0SST, VWF
2taurodeoxycholate449.9SST, SCT
3lafutidine449.9SCT, SST
4loxiglumide449.9SST, SCT
5tinzaparin44 1110.8F3, VWF
6hydroxyethyl starch449.7F3, VWF
7ppack449.7F3, VWF
8tirofiban44 1110.6F3, VWF
9prostaglandin j2449.5VEGFA, SERPINE1
10oxyntomodulin44 6010.5SST, SCT
1111-dehydrothromboxane b2449.5SERPINE1, VWF
12anisodamine449.5F3, SERPINE1
13hyaluronic acid44 2410.5VWF, ENG, VEGFA
14quinapril44 50 1111.4VWF, SERPINE1
15thyroxine44 2410.4SCT, VWF, SST
16octreotide44 60 28 1112.4SCT, VEGFA, SST
17tgf beta1449.2SERPINE1, ENG, ACVRL1
18phosphatidylserine44 28 1111.2F3, ENG, VWF
19perindopril44 50 1111.2VWF, VEGFA, SERPINE1
20ristocetin449.1VWF, F3
21c-peptide449.1SERPINE1, SCT, SST
22tranexamic acid44 1110.1F3, SERPINE1, VWF
23oligonucleotide449.1VWF, ENG, ACVRL1, SCT
24sodium nitroprusside449.1VWF, SERPINE1, SST
25desmopressin44 60 28 1112.1SERPINE1, F3, VWF
26hirudin449.1SERPINE1, F3, VWF
27atorvastatin44 50 28 24 1113.1VWF, VEGFA, SERPINE1
28dipyridamole44 60 28 1112.0VWF, SERPINE1, F3
29n(g)-nitro-l-arginine methyl ester449.0SERPINE1, F3
30kininogen449.0SERPINE1, F3, VWF
31aprotinin44 1110.0VWF, SERPINE1, F3
32fluoxetine44 50 28 1112.0SCT, F3, SERPINE1
33homocysteine44 2410.0F3, SERPINE1, VWF
34epsilon aminocaproic acid448.9F3, SERPINE1
35epinephrine44 24 1110.9F3, SCT, VWF, SST
36matrigel448.8ENG, VWF, SERPINE1, VEGFA
37isoproterenol44 119.7SCT, SERPINE1, VWF, SST
38aspirin44 50 28 2411.7F3, VWF, SERPINE1
39adenylate448.6SERPINE1, SCT, VWF, SST
40simvastatin44 50 60 28 24 1113.5VEGFA, VWF, SERPINE1, F3
41prostacyclin448.5F3, SERPINE1, VWF, VEGFA
42aspartate448.5VWF, SCT, SERPINE1, F3
43testosterone44 60 24 1111.5SCT, SERPINE1, SST, VWF
44heparin44 28 24 1111.4VWF, F3, SERPINE1, VEGFA
45cycloheximide448.3F3, SST, SERPINE1, VEGFA
46dexamethasone44 50 28 1111.3VEGFA, SST, ENG, VWF, SERPINE1
47retinoic acid44 249.0F3, SERPINE1, SCT, SST, VWF
48cyclophosphamide44 50 1110.0SERPINE1, VWF, F3, VEGFA, SST
49serine447.9ACVRL1, F3, SERPINE1, SCT, VWF, ENG
50vegf447.3SST, VWF, VEGFA, SERPINE1, F3, ACVRL1

GO Terms for genes affiliated with Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310938.8SERPINE1, VEGFA, VWF
2extracellular matrixGO:00310128.6F3, SERPINE1, VWF
3cell surfaceGO:00099868.6ENG, ACVRL1, F3, VEGFA
4extracellular spaceGO:00056157.5VEGFA, SERPINE1, F3, SST, ENG
5extracellular regionGO:00055767.4VWF, VEGFA, SCT, SERPINE1, SST

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of BMP signaling pathwayGO:00305139.9ACVRL1, ENG
2negative regulation of endothelial cell proliferationGO:00019379.8ENG, ACVRL1
3positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.8ENG, ACVRL1
4BMP signaling pathwayGO:00305099.8ENG, ACVRL1
5artery morphogenesisGO:00488449.7ENG, VEGFA
6chronological cell agingGO:00013009.6ENG, SERPINE1
7positive regulation of positive chemotaxisGO:00509279.6F3, VEGFA
8patterning of blood vesselsGO:00015699.5VEGFA, ENG
9positive regulation of endothelial cell proliferationGO:00019389.3ACVRL1, F3, VEGFA
10vasculogenesisGO:00015709.3ENG, VEGFA
11negative regulation of cell migrationGO:00303369.2SERPINE1, ACVRL1, ENG
12transforming growth factor beta receptor signaling pathwayGO:00071799.2SERPINE1, ACVRL1, ENG
13platelet degranulationGO:00025769.0SERPINE1, VEGFA, VWF
14angiogenesisGO:00015259.0ACVRL1, SERPINE1, VEGFA
15platelet activationGO:00301688.9VWF, VEGFA, SERPINE1
16positive regulation of angiogenesisGO:00457668.8VEGFA, SERPINE1, F3
17positive regulation of transcription from RNA polymerase II promoterGO:00459448.6VEGFA, SERPINE1, ACVRL1, ENG
18blood coagulationGO:00075968.4F3, SERPINE1, VEGFA, VWF

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:00504319.8ENG, ACVRL1
2activin bindingGO:00481859.7ENG, ACVRL1
3transforming growth factor beta-activated receptor activityGO:00050249.5ENG, ACVRL1
4protease bindingGO:00020208.6F3, SERPINE1, VWF

Sources for Angiodysplasia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet