MCID: ANG011
MIFTS: 44

Angiodysplasia malady

Categories: Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Angiodysplasia

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Aliases & Descriptions for Angiodysplasia:

Name: Angiodysplasia 11 49 38 13 67
Angiodysplasia of Stomach and Duodenum with Hemorrhage 11
 
Angiodysplasia of Colon 67

Classifications:



External Ids:

Disease Ontology11 DOID:2494
ICD9CM31 537.83
SNOMED-CT61 71072006
MeSH38 D016888

Summaries for Angiodysplasia

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Wikipedia:70 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards based summary: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to angiodysplasia of intestine and nevada syndrome. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways are Id Signaling Pathway and HIF-1-alpha transcription factor network. Affiliated tissues include colon, small intestine and endothelial, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Disease Ontology:11 A vascular disease that is characterized as a small vascular malformation of the gut.

Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1angiodysplasia of intestine11.8
2nevada syndrome10.8
3angioosteohypotrophic syndrome10.8
4leydig cell tumor10.4VEGFA, VWF
5colorectal adenoma10.4FGF2, VEGFA
6larynx carcinoma in situ10.4VEGFA, VWF
7ischemic heart disease10.4VEGFA, VWF
8gastric small cell carcinoma10.3FGF2, VEGFA
9vitreous abscess10.3FGF2, VEGFA
10naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.3FGF2, VEGFA
11tollner horst manzke syndrome10.3FGF2, VEGFA
12epidural abscess10.3FGF2, VEGFA
13aggressive systemic mastocytosis10.3FGF2, SCT
14opportunistic mycosis10.2FGF2, VEGFA
15angina pectoris10.2VEGFA, VWF
16lung carcinoma in situ10.2FGF2, VEGFA
17spinal cord astrocytoma10.2ENG, VEGFA
18placental choriocarcinoma10.2FGF2, VEGFA
19cerebral artery occlusion10.2FGF2, VEGFA
20von willebrand's disease10.2
21nodular degeneration of cornea10.1FGF2, VEGFA
22stoll alembik finck syndrome10.1ACVRL1, ENG
23perinephritis10.1ENG, FGF2
24vhl-related pheochromocytoma10.1ACVRL1, ENG
25renal fibrosis10.1FGF2, VEGFA, VWF
26lung adenoid cystic carcinoma10.1ENG, FGF2
27homocystinuria caused by cystathionine beta-synthase deficiency10.1ACVRL1, ENG
28adrenal rest tumor10.1FGF2, VEGFA, VWF
29lethal congenital contractural syndrome 210.0SST, VEGFA
30preeclampsia/eclampsia 110.0ENG, VEGFA
31neuronal ceroid lipofuscinosis10.0SCT, SST
32diabetes mellitus, transient neonatal, 310.0SCT, SST
33pancreatic cystadenocarcinoma10.0SCT, SST
34central nervous system germ cell tumor10.0SST, VWF
35peripheral epithelioid sarcoma10.0SCT, SST
36carcinoma of the vocal tract10.0SST, VEGFA
37primary progressive multiple sclerosis10.0SCT, SST
38pancreatic gastrinoma10.0SCT, SST
39migraine with aura10.0SCT, SST
40dental pulp disease10.0FGF2, VEGFA
41neuropathy, hereditary sensory, type ib10.0FGF2, VEGFA
42glucosidase acid-1,4-alpha deficiency10.0SCT, SST
43ferguson-smith tumor10.0SCT, SST
44dermatitis10.0SST, VEGFA
45chikungunya9.9ENG, VEGFA, VWF
46cerebellar disease9.9ENG, VEGFA
47bladder neck cancer9.9ACVRL1, FGF2, VEGFA
48chondroma9.9ENG, VEGFA
49bubonic plague9.9SST, VEGFA
50duodenitis9.9

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Symptoms for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 4, Phase 2, Phase 311237439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
2
SomatostatinapprovedPhase 2, Phase 322938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
3
Octreotideapproved, investigationalPhase 2, Phase 321383150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
4
Proton pump inhibitorsPhase 2, Phase 31080
Synonyms:
 
PPIs
5Antineoplastic Agents, HormonalPhase 2, Phase 35407
6Gastrointestinal AgentsPhase 2, Phase 38109
7Angiogenesis InhibitorsPhase 2, Phase 14143
8Angiogenesis Modulating AgentsPhase 2, Phase 14072
9Immunosuppressive AgentsPhase 2, Phase 112770
10Anti-Bacterial AgentsPhase 2, Phase 110884
11Anti-Infective AgentsPhase 2, Phase 121402
12Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767
13Hormone AntagonistsPhase 212778
14HormonesPhase 213979
15PomalidomideapprovedPhase 112319171-19-8
16
Infliximabapproved378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
17Hemostatics1359
18ColaNutraceutical1881

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Capsule Endoscopy vs Standard of Care for Obscure Intestinal BleedingUnknown statusNCT00694954Phase 4
2Cyrotherapy vs. APC in GAVECompletedNCT00587405Phase 2, Phase 3
3Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical TrialCompletedNCT01601639Phase 3
4Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to AngiodysplasiasRecruitingNCT02384122Phase 2, Phase 3
5Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment FailureCompletedNCT02622906Phase 2
6Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular MalformationCompletedNCT00964496Phase 2
7Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal BleedingCompletedNCT00389935Phase 2
8Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related BleedingWithdrawnNCT02754960Phase 2
9Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I StudyUnknown statusNCT02287558Phase 1
10Study of Hemospray for Lower Gastrointestinal HemorrhageCompletedNCT02099435
11Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam CapsuleCompletedNCT01820182
12Prophylactic Elective Clipping of Colonic DiverticulaRecruitingNCT02094456

Search NIH Clinical Center for Angiodysplasia


Cochrane evidence based reviews: angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

35
Colon, Small intestine, Endothelial, Liver, Lung, Bone, Appendix

Animal Models for Angiodysplasia or affiliated genes

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MGI Mouse Phenotypes related to Angiodysplasia:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9ACVRL1, ENG, SST, VEGFA, VWF
2MP:00053767.7ACVRL1, CADPS, ENG, FGF2, SST, VEGFA
3MP:00107687.7ACVRL1, CADPS, ENG, FGF2, SST, VEGFA
4MP:00036316.9ACVRL1, CADPS, ENG, FGF2, SST, VEGFA

Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50)    (show all 442)
idTitleAuthorsYear
1
Popliteal Artery Entrapment and Fibular Angiodysplasia in Siblings. (27480046)
2016
2
Analysis of risk factor and clinical characteristics of angiodysplasia presenting as upper gastrointestinal bleeding. (26828247)
2016
3
Use of polymethylmethacrylate in treatment of arteriovenous angiodysplasia with bone lesions. (26355937)
2015
4
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (23661527)
2013
5
Colonic vascular ectasia (angiodysplasia) in a juvenile dog. (23058126)
2013
6
Combined endoclipping and argon plasma coagulation (APC)--daisy technique for cecal angiodysplasia. (24285060)
2013
7
Von Willebrand disease-associated angiodysplasia: a few answers, still many questions. (23432086)
2013
8
Multiple intestinal atresias associated with angiodysplasia in a newborn. (21763851)
2011
9
Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association. (19216082)
2009
10
The mechanisms of thalidomide in treatment of angiodysplasia due to hypoxia]. (19576118)
2009
11
A pseudotumoral angiodysplasia. (19544268)
2009
12
Diffuse colorectal angiodysplasia misdiagnosed preoperatively as ulcerative colitis in a child: report of a case. (18668317)
2008
13
Von Willebrand disease and angiodysplasia responding to atorvastatin. (18510690)
2008
14
Long-term follow-up of patients with small-bowel angiodysplasia on capsule endoscopy. Determinants of a higher clinical impact and rebleeding rate. (18563976)
2008
15
Long-term efficacy of octreotide in the prevention of recurrent bleeding from gastrointestinal angiodysplasia. (17311647)
2007
16
Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. (17024322)
2006
17
Successful colectomy for the treatment of repetitive bleeding from colonic angiodysplasia in a patient with Heyde syndrome. (16617184)
2006
18
Endoscopic detachable mini-loop ligation for treatment of gastroduodenal angiodysplasia: case study of 11 patients with long-term follow-up. (14997147)
2004
19
Angiodysplasia as a cause of gastrointestinal bleeding in childhood. (14747971)
2004
20
Radiology case of the month. Hematochezia in an unstable patient. Acute lower gastrointestinal hemorrhage secondary to angiodysplasia. (15688667)
2004
21
Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy. (12889571)
2003
22
Pedunculated angiodysplasia of the colon successfully treated with endoscopy: a new type of angiodysplasia. (12665782)
2003
23
Selective angiographic catheterisation for jejunal angiodysplasia. (11222835)
2001
24
Migrating site of bleeding in a right colon demonstrating angio-dysplasia following a segmental resection of the colon. A unique variant of angiodysplasia. (11124566)
2000
25
Multiple jejunal angiodysplasia detected by enema-helical CT. (11124471)
2000
26
Type 2B von Willebrand's disease and angiodysplasia. (10595657)
1999
27
Transjugular intrahepatic portosystemic shunt for bleeding angiodysplasia-like lesions in portal-hypertensive colopathy. (9649472)
1998
28
Angiodysplasia in the renal patient: how to diagnose and how to treat? (9761492)
1998
29
Angiodysplasia, haemostasis and capillaries. A hypothesis. (8948067)
1996
30
Angiodysplasia of the colon in children. (7722835)
1995
31
Octreotide in the treatment of bleeding due to angiodysplasia of the small intestine. (8362842)
1993
32
Angiodysplasia of the gastrointestinal tract. (8389094)
1993
33
Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link? (1351610)
1992
34
Does hormonal therapy have any benefit for bleeding angiodysplasia? (1328358)
1992
35
Hormonal therapy for bleeding from angiodysplasia: chronic renal failure, et al?? (2252035)
1990
36
A rare case of angiodysplasia: penetration of inguinal lymph nodes by large superficial leg veins. Report of five cases. (2114699)
1990
37
Endoscopic treatment of colonic angiodysplasia: the procedure was a success, but.... (2323528)
1990
38
Jejunal angiodysplasia presenting as intestinal perforation. (2756994)
1989
39
Angiodysplasia--an uncommon cause of colonic bleeding: colonoscopic evaluation of 1,050 patients with rectal bleeding and anaemia. (3500991)
1987
40
Angiodysplasia in a colonic polyp. (3706089)
1986
41
Aortic stenosis associated with angiodysplasia. (2870037)
1986
42
Cecal angiodysplasia localized by 99mtechnetium blood-pool scintigraphy and specimen venography. (3011267)
1986
43
Renal failure and angiodysplasia of the colon. (3873889)
1985
44
Small intestinal angiodysplasia in the elderly. (6332839)
1984
45
Angiodysplasia. Clinical presentation and colonoscopic diagnosis. (6609803)
1984
46
Plain radiographic, nuclear medicine and angiographic observations of hepatogenic pulmonary angiodysplasia. (6223268)
1983
47
Radiologic analysis of bone structure in congenital angiodysplasia. (7341252)
1981
48
Congenital angiodysplasia with skeletal affection. (7368842)
1980
49
Endoscopic appearance of gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (6967258)
1980
50
Caecal angiodysplasia as a cause of chronic iron deficiency anaemia: a case report. (7403971)
1980

Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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GO Terms for genes affiliated with Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.3VEGFA, VWF
2extracellular spaceGO:00056157.6ENG, FGF2, SCT, SST, VEGFA
3extracellular regionGO:00055767.4FGF2, SCT, SST, VEGFA, VWF

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1endocardial cushion to mesenchymal transitionGO:009050010.4ACVRL1, ENG
2endocardial cushion morphogenesisGO:000320310.3ACVRL1, ENG
3artery morphogenesisGO:004884410.2ENG, VEGFA
4positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.2ACVRL1, ENG
5positive regulation of BMP signaling pathwayGO:003051310.2ACVRL1, ENG
6vasculogenesisGO:000157010.0ENG, VEGFA
7cell migration involved in sprouting angiogenesisGO:000204210.0FGF2, VEGFA
8positive regulation of blood vessel endothelial cell migrationGO:004353610.0FGF2, VEGFA
9positive regulation of endothelial cell migrationGO:001059510.0FGF2, VEGFA
10positive regulation of cell divisionGO:00517819.9FGF2, VEGFA
11positive chemotaxisGO:00509189.9FGF2, VEGFA
12dorsal aorta morphogenesisGO:00359129.8ACVRL1, ENG
13positive regulation of epithelial cell proliferationGO:00506799.7FGF2, VEGFA
14negative regulation of blood vessel endothelial cell migrationGO:00435379.7ACVRL1, FGF2
15positive regulation of MAP kinase activityGO:00434069.7FGF2, VEGFA
16positive regulation of endothelial cell proliferationGO:00019389.5ACVRL1, FGF2, VEGFA
17positive regulation of protein phosphorylationGO:00019349.4ENG, FGF2, VEGFA
18positive regulation of angiogenesisGO:00457669.0ACVRL1, ENG, FGF2, VEGFA
19positive regulation of gene expressionGO:00106288.9ENG, FGF2, VEGFA
20angiogenesisGO:00015258.8ACVRL1, ENG, FGF2, VEGFA
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.6ACVRL1, ENG, FGF2, VEGFA

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1activin bindingGO:004818510.0ACVRL1, ENG
2chemoattractant activityGO:00420569.4FGF2, VEGFA
3transforming growth factor beta bindingGO:00504319.4ACVRL1, ENG

Sources for Angiodysplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet