MCID: ANG011
MIFTS: 48

Angiodysplasia

Categories: Gastrointestinal diseases, Cardiovascular diseases

Aliases & Classifications for Angiodysplasia

MalaCards integrated aliases for Angiodysplasia:

Name: Angiodysplasia 12 51 41 14 69
Angiodysplasia of Stomach and Duodenum with Hemorrhage 12
Angiodysplasia of Colon 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2494
ICD9CM 34 537.83
MeSH 41 D016888
SNOMED-CT 64 71072006
ICD10 32 K55.2

Summaries for Angiodysplasia

Disease Ontology : 12 A vascular disease that is characterized as a small vascular malformation of the gut.

MalaCards based summary : Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to pulmonary arteriovenous malformation and glucagonoma. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Endochondral Ossification and HIF-1-alpha transcription factor network. The drugs Iron and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and endothelial, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia : 72 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

Related Diseases for Angiodysplasia

Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 pulmonary arteriovenous malformation 29.5 ACVRL1 ENG
2 glucagonoma 29.4 SCT SST
3 arteriovenous malformation 29.3 ACVRL1 ENG VEGFA
4 portal hypertension 29.3 SST VEGFA VWF
5 hereditary hemorrhagic telangiectasia 29.2 ACVRL1 ENG VEGFA VWF
6 vascular disease 28.9 ACVRL1 FGF2 VEGFA VWF
7 angiodysplasia of intestine 11.9
8 angioosteohypotrophic syndrome 11.2
9 nevada syndrome 10.9
10 von willebrand's disease 10.4
11 infiltrating angiolipoma 10.4 VEGFA VWF
12 lymphangiosarcoma 10.3 VEGFA VWF
13 chronic myocardial ischemia 10.3 FGF2 VEGFA
14 radiation proctitis 10.3 FGF2 VEGFA
15 hepatopulmonary syndrome 10.3 VEGFA VWF
16 angiomatous meningioma 10.2 FGF2 VEGFA
17 intermittent claudication 10.2 VEGFA VWF
18 dupuytren contracture 10.2 FGF2 VEGFA
19 vitreous disease 10.2 FGF2 VEGFA
20 glomeruloid hemangioma 10.2 ENG VEGFA
21 squamous cell carcinoma of the hypopharynx 10.2 ENG VEGFA
22 corneal neovascularization 10.1 FGF2 VEGFA
23 angiosarcoma 10.1 VEGFA VWF
24 connective tissue cancer 10.1 FGF2 VEGFA
25 breast carcinoma in situ 10.1 FGF2 VEGFA
26 keratitis, hereditary 10.1 FGF2 VEGFA
27 pulmonary hypertension, primary, 1 10.1 ACVRL1 ENG
28 heritable pulmonary arterial hypertension 10.0 ACVRL1 ENG
29 limb ischemia 10.0 FGF2 VEGFA VWF
30 lacrimal gland adenocarcinoma 10.0 ENG FGF2
31 arteriovenous malformations of the brain 10.0 ACVRL1 ENG
32 chronic mountain sickness 10.0 SST VEGFA
33 arteries, anomalies of 10.0 ACVRL1 VEGFA VWF
34 hyperinsulinemic hypoglycemia, familial, 2 10.0 SCT SST
35 carcinoid syndrome 10.0 SST VEGFA
36 iron metabolism disease 10.0
37 duodenitis 10.0
38 duodenogastric reflux 10.0 SCT SST
39 pancreatic cholera 10.0 SCT SST
40 dumping syndrome 10.0 SCT SST
41 zollinger-ellison syndrome 9.9 SCT SST
42 pericardial effusion 9.9 ACVRL1 FGF2 VEGFA
43 aortic valve disease 1 9.9
44 bernard-soulier syndrome 9.9
45 aortic valve disease 2 9.9
46 mucositis 9.9
47 endotheliitis 9.9
48 gastrinoma 9.9 SCT SST
49 pancreatic gastrinoma 9.9 SCT SST
50 steatorrhea 9.9 SCT SST

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to Angiodysplasia

Symptoms & Phenotypes for Angiodysplasia

MGI Mouse Phenotypes related to Angiodysplasia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ACVRL1 CADPS ENG FGF2 SST VEGFA
2 digestive/alimentary MP:0005381 9.65 ACVRL1 ENG SST VEGFA VWF
3 mortality/aging MP:0010768 9.5 ACVRL1 CADPS ENG FGF2 SST VEGFA
4 nervous system MP:0003631 9.17 ACVRL1 CADPS ENG FGF2 SST VEGFA

Drugs & Therapeutics for Angiodysplasia

Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 2, Phase 3 7439-89-6 23925
2
Somatostatin Approved, Investigational Phase 2, Phase 3 38916-34-6, 51110-01-1 53481605
3
Octreotide Approved, Investigational Phase 2, Phase 3 83150-76-9 6400441 383414
4 Proton pump inhibitors Phase 2, Phase 3
5 Antineoplastic Agents, Hormonal Phase 2, Phase 3
6 Gastrointestinal Agents Phase 2, Phase 3
7 Hormone Antagonists Phase 2
8 Hormones Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
10 Angiogenesis Inhibitors Phase 2,Phase 1
11 Angiogenesis Modulating Agents Phase 2,Phase 1
12 Anti-Bacterial Agents Phase 2,Phase 1
13 Anti-Infective Agents Phase 2,Phase 1
14 Immunosuppressive Agents Phase 2,Phase 1
15 Pomalidomide Approved Phase 1 19171-19-8
16
Infliximab Approved 170277-31-3
17 Hemostatics
18 Cola Nutraceutical

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Cyrotherapy vs. APC in GAVE Completed NCT00587405 Phase 2, Phase 3
2 Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical Trial Completed NCT01601639 Phase 3
3 Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Angiodysplasias Recruiting NCT02384122 Phase 2, Phase 3 Octreotide
4 Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure Completed NCT02622906 Phase 2 Pasireotide;Placebo
5 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation Completed NCT00964496 Phase 2 Thalidomide;Iron
6 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
7 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
8 Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding Withdrawn NCT02754960 Phase 2 Thalidomide;Placebo
9 Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I Study Recruiting NCT02287558 Phase 1 Pomalidomide
10 Study of Hemospray for Lower Gastrointestinal Hemorrhage Completed NCT02099435
11 Clinical and Molecular Characterization of Cerebral Proliferative Vasculopathy Completed NCT03293134
12 Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule Completed NCT01820182
13 Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding Completed NCT00694954
14 Prophylactic Elective Clipping of Colonic Diverticula Recruiting NCT02094456
15 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395

Search NIH Clinical Center for Angiodysplasia

Cochrane evidence based reviews: angiodysplasia

Genetic Tests for Angiodysplasia

Anatomical Context for Angiodysplasia

MalaCards organs/tissues related to Angiodysplasia:

38
Colon, Small Intestine, Endothelial, Liver, Lung, Appendix, Bone

Publications for Angiodysplasia

Articles related to Angiodysplasia:

(show top 50) (show all 460)
# Title Authors Year
1
Lenalidomide as a novel therapy for gastrointestinal angiodysplasia in von Willebrand disease. ( 29446520 )
2018
2
Role of transesophageal echocardiography during left atrial appendage occlusion device closure in a patient with non-valvular atrial fibrillation and angiodysplasia of the colon. ( 29336404 )
2018
3
von Willebrand disease and extra-intestinal angiodysplasia. ( 28574209 )
2017
4
Gastrointestinal Angiodysplasia: Diagnosis and Management. ( 27908518 )
2017
5
Tranexamic acid in treatment-resistant chronic transfusion-dependent gastrointestinal angiodysplasia bleeding. ( 29092972 )
2017
6
Automated angiodysplasia detection from wireless capsule endoscopy. ( 29060568 )
2017
7
Role of Octreotide in Pediatric Gastrointestinal Bleeding Secondary to Angiodysplasia in Children with Right Heart Failure. ( 28614113 )
2017
8
Ileal angiodysplasia presentation as a bowel obstruction: A case report. ( 28892784 )
2017
9
Nonisolated Small Bowel Gastrointestinal Angiodysplasias are Associated With Higher Rebleeding Rates When Compared With Isolated Small Bowel Gastrointestinal Angiodysplasia on Video Capsule Endoscopy. ( 28617760 )
2017
10
Hemorrhagic angiodysplasia of the digestive tract: pathogenesis, diagnosis, and management. ( 28554655 )
2017
11
Intractable anemia due to extensive refractory angiodysplasia of the small intestine stabilized by an anti-angiogenic agent. ( 28062159 )
2017
12
Multiple angiodysplasia diagnosed by capsule endoscopy. ( 28280628 )
2017
13
Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann's Thrombasthenia. ( 28670433 )
2017
14
Decreased health-related quality of life in angiodysplasia patients: A cross-sectional cohort. ( 28552982 )
2017
15
Continuous-Flow LVAD Support Causes a Distinct Form of Intestinal Angiodysplasia. ( 28729354 )
2017
16
Review on gastrointestinal angiodysplasia throughout the gastrointestinal tract. ( 28395783 )
2017
17
Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia. ( 28868182 )
2017
18
Angiodysplasia in von Willebrand Disease: Understanding the Clinical and Basic Science. ( 28476066 )
2017
19
Persistent Gastrointestinal Angiodysplasia in Heyde's Syndrome after Aortic Valve Replacement. ( 28824071 )
2017
20
Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells. ( 28003433 )
2016
21
Hemobilia from Biliary Angiodysplasia Diagnosed with Cholangioscopy. ( 27807584 )
2016
22
Hematochezia due to Angiodysplasia of the Appendix. ( 27437394 )
2016
23
Risk factors for active bleeding from colonic angiodysplasia confirmed by colonoscopic observation. ( 27596107 )
2016
24
In-hospital weekend outcomes in patients diagnosed with bleedingA gastroduodenal angiodysplasia: a population-based study,A 2000 toA 2011. ( 26972023 )
2016
25
Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono-centre trial. ( 26966525 )
2016
26
Thalidomide for the treatment of angiodysplasia in a patient with acute upper gastrointestinal haemorrhage. ( 26791122 )
2016
27
Popliteal Artery Entrapment and Fibular Angiodysplasia in Siblings. ( 27480046 )
2016
28
Use of endoscopic-assisted argon plasma coagulation for the treatment of colonic vascular ectasia (angiodysplasia) in an adult dog. ( 26885595 )
2016
29
Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia? ( 27352634 )
2016
30
Segmentation of angiodysplasia lesions in WCE images using a MAP approach with Markov Random Fields. ( 28268536 )
2016
31
Gastrointestinal angiodysplasia is associated with significant gastrointestinal bleeding in patients with continuous left ventricular assist devices. ( 27004257 )
2016
32
Multiple Polypoid Angiodysplasia with Obscure Overt Bleeding. ( 26855931 )
2016
33
Colonic Angiodysplasia with a Huge Submucosal Hematoma in the Sigmoid Colon. ( 27340585 )
2016
34
Gastrointestinal bleeding due to angiodysplasia in patients on hemodialysis: A single-center study. ( 27424692 )
2016
35
Hemodialysis Switch Improved Colonic Angiodysplasia in a Peritoneal Dialysis Patient. ( 27659936 )
2016
36
Analysis of risk factor and clinical characteristics of angiodysplasia presenting as upper gastrointestinal bleeding. ( 26828247 )
2016
37
Endothelial dysfunction in von Willebrand disease: angiogenesis and angiodysplasia. ( 27207426 )
2016
38
Thalidomide in angiodysplasia-related bleeding. ( 26332623 )
2015
39
Angiodysplasia: an unusual case of gastrointestinal bleeding. ( 26031261 )
2015
40
Could a Transient Deficiency in Von Willebrand Factor be a Cause of Gastrointestinal Angiodysplasia? ( 25723359 )
2015
41
Clinical features and endoscopic findings in patients with actively bleeding colonic angiodysplasia. ( 25772855 )
2015
42
Thalidomide for treatment of gastrointestinal angiodysplasia in patients with left ventricular assist devices: case series and treatment protocol. ( 25447569 )
2015
43
Use of polymethylmethacrylate in treatment of arteriovenous angiodysplasia with bone lesions. ( 26355937 )
2015
44
Thalidomide for treatment of gastrointestinal bleedings due to angiodysplasia: a case report in acquired von Willebrand syndrome and review of the literature. ( 25929157 )
2015
45
Success of Minimally Invasive Transumbilical Single-Incision Laparoscopic Surgery (T-SILS) Plus Double-Balloon Endoscopy (DBE) for Pediatric Intestinal Angiodysplasia: A Case Report. ( 26011216 )
2015
46
Jejunal angiodysplasia causing recurrent gastrointestinal bleeding presenting as severe anaemia and melena. ( 26567241 )
2015
47
Argon plasma coagulation in the management of symptomatic gastrointestinal angiodysplasia: experience in 69 consecutive patients. ( 26895122 )
2015
48
The natural history of small bowel angiodysplasia. ( 26540240 )
2015
49
Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease. ( 26316703 )
2015
50
Expression of Angiogenic Factors in Patients With Sporadic Small Bowel Angiodysplasia. ( 25319741 )
2014

Variations for Angiodysplasia

Expression for Angiodysplasia

Search GEO for disease gene expression data for Angiodysplasia.

Pathways for Angiodysplasia

GO Terms for Angiodysplasia

Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ENG FGF2 SCT SST VEGFA
2 platelet alpha granule lumen GO:0031093 8.96 VEGFA VWF

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.67 FGF2 SCT SST VEGFA
2 negative regulation of gene expression GO:0010629 9.65 ACVRL1 ENG VEGFA
3 positive regulation of MAP kinase activity GO:0043406 9.58 FGF2 VEGFA
4 vasculogenesis GO:0001570 9.58 ENG VEGFA
5 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.57 ACVRL1 ENG
6 positive regulation of cell division GO:0051781 9.56 FGF2 VEGFA
7 positive chemotaxis GO:0050918 9.55 FGF2 VEGFA
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.54 FGF2 VEGFA
9 positive regulation of BMP signaling pathway GO:0030513 9.52 ACVRL1 ENG
10 branching involved in blood vessel morphogenesis GO:0001569 9.51 ENG VEGFA
11 negative regulation of blood vessel endothelial cell migration GO:0043537 9.49 ACVRL1 FGF2
12 artery morphogenesis GO:0048844 9.46 ENG VEGFA
13 angiogenesis GO:0001525 9.46 ACVRL1 ENG FGF2 VEGFA
14 endocardial cushion morphogenesis GO:0003203 9.43 ACVRL1 ENG
15 positive regulation of endothelial cell proliferation GO:0001938 9.43 ACVRL1 FGF2 VEGFA
16 cell migration involved in sprouting angiogenesis GO:0002042 9.4 FGF2 VEGFA
17 dorsal aorta morphogenesis GO:0035912 9.32 ACVRL1 ENG
18 endocardial cushion to mesenchymal transition GO:0090500 8.96 ACVRL1 ENG
19 positive regulation of angiogenesis GO:0045766 8.92 ACVRL1 ENG FGF2 VEGFA

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 FGF2 VEGFA
2 transforming growth factor beta binding GO:0050431 8.96 ACVRL1 ENG
3 activin binding GO:0048185 8.62 ACVRL1 ENG

Sources for Angiodysplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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