MCID: ANG011
MIFTS: 50

Angiodysplasia malady

Gastrointestinal diseases category

Summaries for Angiodysplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to von willebrand's disease and hypertension. An important gene associated with Angiodysplasia is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are TGF-beta/Smad Signaling and HIF-1-alpha transcription factor network. The compounds aspartate and heparin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Angiodysplasia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

angiodysplasia 8 10 44 60
angiodysplasia of stomach and duodenum with hemorrhage 8


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Disease Ontology8 DOID:2494
SNOMED-CT56 71072006
MeSH34 D016888

Related Diseases for Angiodysplasia

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17GeneCards, 18GeneDecks
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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1von willebrand's disease30.8F3, VWF
2hypertension30.4SERPINE1
3hereditary hemorrhagic telangiectasia30.2ENG, ACVRL1
4hemangioma30.0VEGFA
5arteriovenous malformation30.0ACVRL1, ENG
6ischemia30.0VEGFA, ENG
7colon cancer29.8ENG, VEGFA
8lung cancer29.8SST, VEGFA
9hemorrhagic disease29.8VWF, F3
10deficiency anemia29.7F3, ENG, VWF
11vascular disease29.7VEGFA, F3, VWF
12adenocarcinoma29.7ENG, SCT, SST, VEGFA
13liver cirrhosis29.7SCT, F3, SST
14angiodysplasia of intestine10.5
15duodenitis10.2
16aortic disease10.2
17aortic valve stenosis10.2
18bernard-soulier syndrome10.2
19klippel-trenaunay syndrome10.1
20meckel's diverticulum10.1
21colonic disease10.1
22renal agenesis10.0
23ainhum10.0
24portal hypertension10.0
25gastric antral vascular ectasia10.0
26hypertrophic cardiomyopathy10.0
27esophagitis10.0
28myelofibrosis10.0
29renal hypertension10.0
30image syndrome10.0
31primary pulmonary hypertension10.0ACVRL1
32sickle cell disease10.0VWF
33osteoarthritis10.0ENG
34hypothyroidism10.0VWF
35intracranial aneurysm10.0ENG
36leukemia10.0ENG
37hyperparathyroidism10.0SCT
38hemolytic-uremic syndrome10.0VWF
39angiosarcoma10.0VWF
40asthma10.0SCT
41varicose veins10.0SST
42retinal vein occlusion10.0VEGFA
43blindness10.0VEGFA
44central retinal vein occlusion10.0VEGFA
45hyperthyroidism10.0SST
46neuroendocrine tumor10.0SST
47meningioma10.0SST
48diarrhea10.0SST
49age related macular degeneration10.0VEGFA
50pituitary adenoma10.0SST

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Clinical Features for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Angiodysplasia

Search CenterWatch for Angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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32MalaCards
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MalaCards organs/tissues related to Angiodysplasia:

32
Colon, Small intestine, Liver, Endothelial, Lung, Tongue, Bone, Kidney, Lymph node, Appendix

Animal Models for Angiodysplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiodysplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.9ENG, F3, ACVRL1
2MP:00053768.8SCT, VWF, ACVRL1, SERPINE1
3MP:00028737.6F3, ACVRL1, ENG, SST, VEGFA
4MP:00053977.3VWF, ENG, SERPINE1, ACVRL1, VEGFA, F3
5MP:00053787.3ENG, SERPINE1, F3, SST, VEGFA, ACVRL1
6MP:00036317.1ENG, ACVRL1, VWF, F3, SST, VEGFA

Publications for Angiodysplasia

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50PubMed
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Articles related to Angiodysplasia:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Tamoxifen for recurrent bleeds due to angiodysplasia in von Willebrand's disease. (23731407)
2013
2
Increased incidence of angiodysplasia of the gastrointestinal tract and bleeding in patients with continuous flow left ventricular assist devices (LVADs). (23897227)
2013
3
Angiodysplasia of the colon: a report of two cases and review of literature. (22437102)
2012
4
Angiodysplasia of the gallbladder. (22096745)
2011
5
Multiple intestinal atresias associated with angiodysplasia in a newborn. (21763851)
2011
6
Meningocerebral angiodysplasia with metanephric induction failure: Broadening the spectrum of an emerging maldevelopmental syndrome. (21664057)
2011
7
Von Willebrand disease, angiodysplasia and atorvastatin. (19995387)
2010
8
Successful endoscopic clipping for bleeding from colonic angiodysplasia in a case of Heyde syndrome. (20802419)
2010
9
The mechanisms of thalidomide in treatment of angiodysplasia due to hypoxia]. (19576118)
2009
10
Gastrointestinal angiodysplasia in three Saudi children. (19448365)
2009
11
Somatostatin analogues in the treatment of bleeding GI-angiodysplasias]. (18397628)
2008
12
Angiodysplasia of colon in a seven-year-old boy: a rare cause of intestinal bleeding. (18097128)
2007
13
Bleeding angiodysplasia of the major duodenal papilla: how should it be handled? (16832563)
2006
14
Small-bowel angiodysplasia and intestinal bleeding: a diagnostic challenge. (17140917)
2006
15
Angiodysplasia of the major duodenal papilla: a rare cause of GI bleeding. (16650558)
2006
16
A novel method of treating colonic angiodysplasia. (16923494)
2006
17
Peritonitis following argon plasma coagulation of colonic angiodysplasia in a CAPD patient--an avoidable complication? (16178486)
2005
18
Gastrointestinal stromal tumor of jejunum with angiodysplasia. (15185876)
2004
19
Coronary and valve angiodysplasia unmasked by eosinophilic vasculitis and endomyocarditis. (15539748)
2004
20
The use of wireless capsule endoscopy to detect small bowel angiodysplasia in a patient with obscure gastrointestinal bleeding and von Willebrand disease. (15095862)
2004
21
Angiodysplasia as a cause of recurrent bleeding from the small bowel in patients with von Willebrand disease. Report of 4 patients. (15757205)
2004
22
Bleeding small bowel angiodysplasia in association with aortic stenosis: a role for combined wireless capsule endoscopy and push enteroscopy? (15365425)
2004
23
Asymptomatic gastric angiodysplasia in chronic hemodialysis patients: case reports. (17657090)
2003
24
Avoid hormones in gastrointestinal angiodysplasia. (12401283)
2002
25
The management of von Willebrand's disease-associated gastrointestinal angiodysplasia. (11302477)
2001
26
Diffuse angiodysplasia of the upper gastrointestinal tract in a patient with hypertrophic obstructive cardiomyopathy. (10830178)
2000
27
Octreotide in the treatment of gastrointestinal bleeding caused by angiodysplasia in two patients with von Willebrand's disease. (10759709)
2000
28
Enteroscopy and cautery for small intestinal angiodysplasia. (9041020)
1997
29
Gastrointestinal angiodysplasia in constitutional thrombocytopathies. (9195784)
1997
30
Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia. (8898427)
1996
31
Upper-gastrointestinal bleeding from angiodysplasia of the minor papilla. (8742655)
1996
32
A prospective controlled evaluation of endoscopic detection of angiodysplasia and its association with aortic valve disease. (8566626)
1995
33
Angiodysplasia and aortic valve disease: let's close the book on this association. (8566646)
1995
34
Gastrointestinal bleeding caused by angiodysplasia: a difficult problem in patients with chronic renal failure receiving hemodialysis therapy. (8214961)
1993
35
Pathological case of the month. Pulmonary angiodysplasia. (1558076)
1992
36
Sudden death in angiodysplasia of the gastroesophageal junction. (1476124)
1992
37
Catheter-guided intraoperative localization of a jejunal angiodysplasia using the Tracker-18 coaxial catheter system: case report. (1756554)
1991
38
Occult aspirin intake revealed by a bleeding colonic angiodysplasia. (2058648)
1991
39
Association of von Willebrand's disease with plasma cell dyscrasia and gastrointestinal angiodysplasia. (2121664)
1990
40
Calcific aortic-valve stenosis and angiodysplasia of the colon: Heyde's syndrome--report of two cases. (2291237)
1990
41
Angiodysplasia as a cause of iron deficiency anaemia. (2676033)
1989
42
Phenol sympathectomy for symptomatic fibromuscular angiodysplasia of the lower limb. (2708443)
1989
43
Pathology of angiodysplasia in Klippel-Trenaunay syndrome. (2851776)
1988
44
What is angiodysplasia? (3487490)
1986
45
"Angiodysplasia' of the tongue with acquired von Willebrand's disease. (6979744)
1982
46
Bleeding from gastric angiodysplasia post aortic valve replacement. (6979492)
1982
47
Angiodysplasia. (6118730)
1981
48
Ainhum and angiodysplasia. (6115161)
1981
49
Caecal angiodysplasia as a cause of chronic iron deficiency anaemia: a case report. (7403971)
1980
50
Angiodysplasia of the colon: a cause of rectal bleeding. (311247)
1977-1978

Genetic Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiodysplasia

Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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4Cell Signaling Technology, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Angiodysplasia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Angiodysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1aspartate4410.4SCT
2heparin44 28 11 2413.3VEGFA
3matrigel4410.3SERPINE1
4serine4410.1SCT, ACVRL1
5dexamethasone44 49 28 1113.0ENG, VEGFA
6gelofusine4410.0SST, VWF
7taurodeoxycholate449.9SST, SCT
8lafutidine449.9SST, SCT
9loxiglumide449.9SCT, SST
1011-dehydrothromboxane b2449.8SERPINE1, VWF
11prostaglandin j2449.7VEGFA, SERPINE1
12quinapril44 1110.7SERPINE1, VWF
13oxyntomodulin44 5910.6SCT, SST
14tinzaparin44 1110.6VWF, F3
15hydroxyethyl starch449.6F3, VWF
16n(g)-nitro-l-arginine methyl ester449.6F3
17ppack449.5VWF, F3
18tirofiban44 1110.5F3, VWF
19anisodamine449.5F3, SERPINE1
20tgf beta1449.4SERPINE1, ENG, ACVRL1
21hyaluronic acid44 2410.4VWF, VEGFA, ENG
22octreotide44 59 28 1112.4SCT, VEGFA, SST
23perindopril44 49 1111.4VEGFA, SERPINE1, VWF
24thyroxine44 2410.3SST, SCT, VWF
25sodium nitroprusside449.3SERPINE1, SST, VWF
26c-peptide449.3SCT, SST, SERPINE1
27atorvastatin44 49 28 11 2413.3SERPINE1, VWF, VEGFA
28ticlopidine44 1110.2VWF, F3
29epsilon aminocaproic acid449.2F3, SERPINE1
30tranexamic acid44 1110.1F3, SERPINE1, VWF
31desmopressin44 59 28 1112.1F3, VWF, SERPINE1
32hirudin449.1SERPINE1, VWF, F3
33dipyridamole44 59 28 1112.0F3, VWF, SERPINE1
34phosphatidylserine44 28 1111.0VWF, ENG, F3
35kininogen449.0VWF, F3, SERPINE1
36aprotinin44 1110.0VWF, SERPINE1, F3
37fluoxetine49 44 28 1112.0SCT, F3, SERPINE1
38homocysteine44 2410.0F3, VWF, SERPINE1
39oligonucleotide449.0ACVRL1, ENG, VWF, SCT
40ristocetin448.9VWF, F3
41isoproterenol44 119.9VWF, SCT, SST, SERPINE1
42adenylate448.8SCT, SST, SERPINE1, VWF
43epinephrine44 11 2410.7F3, VWF, SST, SCT
44testosterone44 59 11 2411.7SCT, SST, SERPINE1, VWF
45aspirin44 49 28 2411.6SERPINE1, F3, VWF
46simvastatin44 49 59 28 11 2413.5SERPINE1, F3, VWF, VEGFA
47cyclophosphamide44 49 1110.5F3, SST, SERPINE1, VWF
48prostacyclin448.5VWF, SERPINE1, VEGFA, F3
49retinoic acid44 249.0SERPINE1, VWF, F3, SST, SCT
50vegf447.3SERPINE1, VWF, ACVRL1, ENG, SST, VEGFA

GO Terms for genes affiliated with Angiodysplasia

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16Gene Ontology
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Cellular components related to Angiodysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0VEGFA, VWF, SERPINE1
2extracellular matrixGO:0310128.3SERPINE1, VWF, F3
3cell surfaceGO:0099868.3F3, VEGFA, ACVRL1, ENG
4extracellular regionGO:0055767.9SCT, VEGFA, SST, VWF, SERPINE1
5extracellular spaceGO:0056157.6VEGFA, SST, F3, SERPINE1, ENG

Biological processes related to Angiodysplasia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of BMP signaling pathwayGO:0305139.9ENG, ACVRL1
2chronological cell agingGO:0013009.8ENG, SERPINE1
3artery morphogenesisGO:0488449.8VEGFA, ENG
4negative regulation of endothelial cell proliferationGO:0019379.7ACVRL1, ENG
5patterning of blood vesselsGO:0015699.6VEGFA, ENG
6positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.5ACVRL1, ENG
7negative regulation of cell migrationGO:0303369.4ENG, SERPINE1, ACVRL1
8positive regulation of positive chemotaxisGO:0509279.4F3, VEGFA
9transforming growth factor beta receptor signaling pathwayGO:0071799.4SERPINE1, ENG, ACVRL1
10platelet degranulationGO:0025769.2SERPINE1, VWF, VEGFA
11angiogenesisGO:0015259.1VEGFA, ACVRL1, SERPINE1
12positive regulation of endothelial cell proliferationGO:0019389.1VEGFA, ACVRL1, F3
13platelet activationGO:0301689.0VEGFA, SERPINE1, VWF
14positive regulation of angiogenesisGO:0457668.8SERPINE1, F3, VEGFA
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.6VEGFA, SERPINE1, ENG, ACVRL1
16blood coagulationGO:0075968.3SERPINE1, VWF, F3, VEGFA

Molecular functions related to Angiodysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta-activated receptor activityGO:0050249.8ENG, ACVRL1
2activin bindingGO:0481859.7ENG, ACVRL1
3transforming growth factor beta bindingGO:0504319.5ENG, ACVRL1
4protease bindingGO:0020208.6SERPINE1, VWF, F3

Products for genes affiliated with Angiodysplasia

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Sources for Angiodysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet