MCID: ANG011
MIFTS: 45

Angiodysplasia malady

Categories: Gastrointestinal diseases, Cardiovascular diseases

Aliases & Classifications for Angiodysplasia

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Aliases & Descriptions for Angiodysplasia:

Name: Angiodysplasia 10 47 12 36 65
Angiodysplasia of Stomach and Duodenum with Hemorrhage 10
 
Angiodysplasia of Colon 65

Classifications:



External Ids:

Disease Ontology10 DOID:2494
ICD9CM29 537.83
SNOMED-CT59 71072006
MeSH36 D016888
ICD1027 K55.2
UMLS65 C0085411, C0156091, C0267370

Summaries for Angiodysplasia

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Wikipedia:68 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards based summary: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to angiodysplasia of intestine and nevada syndrome. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways are Id Signaling Pathway and HIF-1-alpha transcription factor network. Affiliated tissues include colon, lung and brain, and related mouse phenotypes are respiratory system and digestive/alimentary.

Disease Ontology:10 A vascular disease that is characterized as a small vascular malformation of the gut.

Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1angiodysplasia of intestine11.9
2nevada syndrome10.9
3angioosteohypotrophic syndrome10.9
4refractory plasma cell neoplasm10.4VEGFA, VWF
5myoma10.4VEGFA, VWF
6liver lymphoma10.4VEGFA, VWF
7intraocular lymphoma10.3VEGFA, VWF
8von willebrand's disease10.3
9tendinopathy10.3VEGFA, VWF
10chronic venous insufficiency10.2VEGFA, VWF
11protein-energy malnutrition10.2ACVRL1, VEGFA
12grayson-wilbrandt corneal dystrophy10.2ENG, VEGFA
13hidrotic ectodermal dysplasia 210.1ACVRL1, ENG
14preeclampsia/eclampsia 110.1ENG, VEGFA
15cerebral atherosclerosis10.0ACVRL1, ENG
16central nervous system germinoma10.0SST, VWF
17lethal congenital contractural syndrome 210.0SST, VEGFA
18duodenitis10.0
19pancreatic cystadenocarcinoma10.0SCT, SST
20glucose-6-phosphate translocase deficiency10.0SCT, SST
21dentin sensitivity10.0SCT, SST
22cholesterol ester storage disease10.0SCT, SST
23inhibited male orgasm10.0SCT, SST
24ampulla of vater neoplasm10.0SCT, SST
25dyskinesia of esophagus10.0SST, VEGFA
26hereditary hemorrhagic telangiectasia10.0
27secondary progressive multiple sclerosis10.0SCT, SST
28lung giant cell carcinoma9.9SCT, SST
29thyroid cancer9.9ACVRL1, VEGFA, VWF
30glucose intolerance9.9SCT, SST
31gastric gastrinoma9.9SCT, SST
32postherpetic neuralgia9.9SST, VEGFA
33meckel's diverticulum9.9
34cardiomyopathy9.9
35endotheliitis9.9
36malignant conjunctiva melanoma9.9ENG, VEGFA, VWF
37seminal vesicle acute gonorrhea9.9ENG, VEGFA, VWF
38thrombotic thrombocytopenic purpura9.9SST, VEGFA
39hepatic flexure cancer9.9SCT, SST
40neuropathy, hereditary sensory and autonomic, type vi9.9SST, VEGFA
41hemangioma9.8
42myelofibrosis9.8
43portal hypertension9.8
44arteriovenous malformation9.8
45ainhum9.8
46esophagitis9.8
47gastric antral vascular ectasia9.8
48ischemia9.8
49gastroduodenitis9.8
50acquired von willebrand syndrome9.8

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Symptoms for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 4, Phase 2, Phase 310217439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro
2Contraceptives, OralPhase 43734
3
Octreotideapproved, investigationalPhase 2, Phase 319883150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
 
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Ocphyl
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide acetate
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatin
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
4
Proton pump inhibitorsPhase 2, Phase 3958
Synonyms:
 
PPIs
5
SomatostatinPhase 2, Phase 315351110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
6Gastrointestinal AgentsPhase 2, Phase 36401
7Antineoplastic Agents, HormonalPhase 2, Phase 34256
8Immunologic FactorsPhase 2, Phase 118483
9Immunosuppressive AgentsPhase 2, Phase 110422
10Anti-Infective AgentsPhase 2, Phase 117220
11Angiogenesis InhibitorsPhase 2, Phase 13688
12Angiogenesis Modulating AgentsPhase 2, Phase 13611
13Anti-Bacterial AgentsPhase 2, Phase 19140
14
PomalidomideapprovedPhase 110919171-19-8
Synonyms:
 
Pomalyst
15Hemostatics1082
16ColaNutraceutical1768

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Capsule Endoscopy vs Standard of Care for Obscure Intestinal BleedingRecruitingNCT00694954Phase 4
2Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical TrialCompletedNCT01601639Phase 3
3Cyrotherapy vs. APC in GAVECompletedNCT00587405Phase 2, Phase 3
4Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Small Bowel AngiodysplasiasRecruitingNCT02384122Phase 2, Phase 3
5Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment FailureCompletedNCT02622906Phase 2
6Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular MalformationCompletedNCT00964496Phase 2
7Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal BleedingCompletedNCT00389935Phase 2
8Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related BleedingWithdrawnNCT02754960Phase 2
9Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I StudyNot yet recruitingNCT02287558Phase 1
10Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam CapsuleCompletedNCT01820182
11Study of Hemospray for Lower Gastrointestinal HemorrhageRecruitingNCT02099435
12Prophylactic Elective Clipping of Colonic DiverticulaRecruitingNCT02094456

Search NIH Clinical Center for Angiodysplasia


Cochrane evidence based reviews: angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

33
Colon, Lung, Brain, Thyroid, Prostate, B cells, Liver

Animal Models for Angiodysplasia or affiliated genes

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MGI Mouse Phenotypes related to Angiodysplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8ACVRL1, CADPS, ENG, VEGFA
2MP:00053818.4ACVRL1, SST, VEGFA, VWF
3MP:00036317.4ACVRL1, CADPS, ENG, SST, VEGFA, VWF
4MP:00107687.4ACVRL1, CADPS, ENG, SST, VEGFA, VWF
5MP:00053767.1ACVRL1, CADPS, ENG, SST, VEGFA, VWF

Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50)    (show all 432)
idTitleAuthorsYear
1
eComment. Doctor Jekyll and Mr Heyde: a vague association between angiodysplasia and aortic stenosis. (25417216)
2014
2
Angiodysplasia in patient with chronic kidney disease. (23374531)
2013
3
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (23661527)
2013
4
Role of vascular endothelial growth factor in angiodysplasia: an interventional study with thalidomide. (22098296)
2012
5
Successful treatment of bleeding gastro-intestinal angiodysplasia in hereditary haemorrhagic telangiectasia with thalidomide. (22674103)
2011
6
Angiodysplasia of the gallbladder. (22096745)
2011
7
Von Willebrand disease, angiodysplasia and atorvastatin. (19995387)
2010
8
Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association. (19216082)
2009
9
The mechanisms of thalidomide in treatment of angiodysplasia due to hypoxia]. (19576118)
2009
10
Diffuse colorectal angiodysplasia misdiagnosed preoperatively as ulcerative colitis in a child: report of a case. (18668317)
2008
11
Von Willebrand disease and angiodysplasia responding to atorvastatin. (18510690)
2008
12
A hypervascular pseudotumor in the liver with angiodysplasia in the center of the lesion: a new entity or a variant of focal nodular hyperplasia? (17652535)
2007
13
Long-term efficacy of octreotide in the prevention of recurrent bleeding from gastrointestinal angiodysplasia. (17311647)
2007
14
Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. (17024322)
2006
15
Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management. (16020106)
2005
16
Pedunculated angiodysplasia of the colon treated with endoscopic resection: a case report. (16110853)
2005
17
Role of hemoclips in a patient with cecal angiodysplasia at high risk of recurrent bleeding from antithrombotic therapy to maintain coronary stent patency: a case report. (16111979)
2005
18
Endoscopic detachable mini-loop ligation for treatment of gastroduodenal angiodysplasia: case study of 11 patients with long-term follow-up. (14997147)
2004
19
Angiodysplasia as a cause of gastrointestinal bleeding in childhood. (14747971)
2004
20
Colonic polypoid angiodysplasia. (12838229)
2003
21
Aortic stenosis and angiodysplasia in the elderly: common things occur commonly? (17670112)
2003
22
Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy. (12889571)
2003
23
Gastrointestinal angiodysplasia and aortic stenosis. (12226167)
2002
24
Selective angiographic catheterisation for jejunal angiodysplasia. (11222835)
2001
25
Angiodysplasia with osteohypertrophy affecting the oromaxillofacial area: clinical findings. (11572256)
2001
26
Migrating site of bleeding in a right colon demonstrating angio-dysplasia following a segmental resection of the colon. A unique variant of angiodysplasia. (11124566)
2000
27
Increased plasma vascular endothelial growth factor levels in patients with angiodysplasia. (10971796)
2000
28
Multiple jejunal angiodysplasia detected by enema-helical CT. (11124471)
2000
29
Type 2B von Willebrand's disease and angiodysplasia. (10595657)
1999
30
Transjugular intrahepatic portosystemic shunt for bleeding angiodysplasia-like lesions in portal-hypertensive colopathy. (9649472)
1998
31
Is there a role for parathormone in the pathogenesis of colonic angiodysplasia? (9568887)
1998
32
Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia. (8898427)
1996
33
Angiodysplasia and lower gastrointestinal tract bleeding in elderly patients. (7717788)
1995
34
Small bowel angiodysplasia: usefulness of peroperative enteroscopy. (8513166)
1993
35
Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link? (1351610)
1992
36
Catheter-guided intraoperative localization of a jejunal angiodysplasia using the Tracker-18 coaxial catheter system: case report. (1756554)
1991
37
Hormonal therapy for bleeding from angiodysplasia: chronic renal failure, et al?? (2252035)
1990
38
A rare case of angiodysplasia: penetration of inguinal lymph nodes by large superficial leg veins. Report of five cases. (2114699)
1990
39
Angiodysplasia: current concepts. (3054852)
1988
40
Angiodysplasia in transposed colon. (3260769)
1988
41
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
42
Angiodysplasia in a colonic polyp. (3706089)
1986
43
Aortic stenosis associated with angiodysplasia. (2870037)
1986
44
Renal failure and angiodysplasia of the colon. (3873889)
1985
45
Acquired angiodysplasia. (6606356)
1983
46
Plain radiographic, nuclear medicine and angiographic observations of hepatogenic pulmonary angiodysplasia. (6223268)
1983
47
Angiodysplasia. (6118730)
1981
48
Congenital angiodysplasia with skeletal affection. (7368842)
1980
49
Gastrointestinal bleeding, angiodysplasia of the colon and acquired von Willebrand's disease. (6968610)
1980
50

Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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Pathways related to Angiodysplasia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5ACVRL1, VEGFA
29.5ENG, VEGFA

GO Terms for genes affiliated with Angiodysplasia

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Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1patterning of blood vesselsGO:00015699.9ENG, VEGFA
2artery morphogenesisGO:00488449.8ENG, VEGFA
3BMP signaling pathwayGO:00305099.8ACVRL1, ENG
4positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.8ACVRL1, ENG
5platelet degranulationGO:00025769.7VEGFA, VWF
6vasculogenesisGO:00015709.6ENG, VEGFA
7negative regulation of cell migrationGO:00303369.3ACVRL1, ENG
8angiogenesisGO:00015259.1ACVRL1, ENG, VEGFA
9positive regulation of angiogenesisGO:00457669.0ACVRL1, ENG, VEGFA

Sources for Angiodysplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet