MCID: ANG011
MIFTS: 50

Angiodysplasia malady

Gastrointestinal diseases category

Summaries for Angiodysplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to von willebrand's disease and hypertension. An important gene associated with Angiodysplasia is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are TGF-beta/Smad Signaling and HIF-1-alpha transcription factor network. The compounds aspartate and heparin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Angiodysplasia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

angiodysplasia 8 10 44 60
angiodysplasia of stomach and duodenum with hemorrhage 8


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Disease Ontology8 DOID:2494
SNOMED-CT56 71072006
MeSH34 D016888

Related Diseases for Angiodysplasia

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17GeneCards, 18GeneDecks
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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1von willebrand's disease30.8F3, VWF
2hypertension30.4SERPINE1
3hereditary hemorrhagic telangiectasia30.2ENG, ACVRL1
4hemangioma30.0VEGFA
5arteriovenous malformation30.0ACVRL1, ENG
6ischemia30.0VEGFA, ENG
7colon cancer29.8ENG, VEGFA
8lung cancer29.8SST, VEGFA
9hemorrhagic disease29.8VWF, F3
10deficiency anemia29.7F3, ENG, VWF
11vascular disease29.7VEGFA, F3, VWF
12adenocarcinoma29.7ENG, SCT, SST, VEGFA
13liver cirrhosis29.7SCT, F3, SST
14angiodysplasia of intestine10.5
15duodenitis10.2
16aortic disease10.2
17aortic valve stenosis10.2
18bernard-soulier syndrome10.2
19klippel-trenaunay syndrome10.1
20meckel's diverticulum10.1
21colonic disease10.1
22renal agenesis10.0
23ainhum10.0
24portal hypertension10.0
25gastric antral vascular ectasia10.0
26hypertrophic cardiomyopathy10.0
27esophagitis10.0
28myelofibrosis10.0
29renal hypertension10.0
30image syndrome10.0
31primary pulmonary hypertension10.0ACVRL1
32sickle cell disease10.0VWF
33osteoarthritis10.0ENG
34hypothyroidism10.0VWF
35intracranial aneurysm10.0ENG
36leukemia10.0ENG
37hyperparathyroidism10.0SCT
38hemolytic-uremic syndrome10.0VWF
39angiosarcoma10.0VWF
40asthma10.0SCT
41varicose veins10.0SST
42retinal vein occlusion10.0VEGFA
43blindness10.0VEGFA
44central retinal vein occlusion10.0VEGFA
45hyperthyroidism10.0SST
46neuroendocrine tumor10.0SST
47meningioma10.0SST
48diarrhea10.0SST
49age related macular degeneration10.0VEGFA
50pituitary adenoma10.0SST

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Clinical Features for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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32MalaCards
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MalaCards organs/tissues related to Angiodysplasia:

32
Colon, Small intestine, Liver, Endothelial, Lung, Tongue, Bone, Kidney, Lymph node, Appendix

Animal Models for Angiodysplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiodysplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.9ENG, ACVRL1, F3
2MP:00053768.8SERPINE1, ACVRL1, VWF, SCT
3MP:00028737.6VEGFA, SST, F3, ACVRL1, ENG
4MP:00053977.3VEGFA, F3, VWF, ACVRL1, SERPINE1, ENG
5MP:00053787.3ENG, SERPINE1, ACVRL1, F3, SST, VEGFA
6MP:00036317.1SCT, VEGFA, SST, F3, VWF, ACVRL1

Publications for Angiodysplasia

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50PubMed
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Articles related to Angiodysplasia:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Combined endoclipping and argon plasma coagulation (APC)--daisy technique for cecal angiodysplasia. (24285060)
2013
2
Small bowel angiodysplasia and novel disease associations: a cohort study. (23356721)
2013
3
An unusual endoscopic image of a submucosal angiodysplasia. (23050173)
2012
4
Colonic angiodysplasia with adenomatous epithelial foci. (22187696)
2011
5
Small bowel ischemia after angiographic embolization for angiodysplasia of lower gastrointestinal tract: the case for conservative management. (21664212)
2011
6
Small bowel lymphangiectasia and angiodysplasia: a positive association; novel clinical marker or shared pathophysiology? (20535025)
2010
7
Hematochezia with colonic polypoid angiodysplasia in a young female patient. (20485622)
2008
8
Long-term efficacy of octreotide in the prevention of recurrent bleeding from gastrointestinal angiodysplasia. (17311647)
2007
9
Successful colectomy for the treatment of repetitive bleeding from colonic angiodysplasia in a patient with Heyde syndrome. (16617184)
2006
10
Acquired von Willebrand's disease associated with gastrointestinal angiodysplasia: a case report. (16834752)
2006
11
Small bowel angiodysplasia associated with von Willebrand's disease: report of a case. (16794806)
2006
12
Pedunculated angiodysplasia of the colon treated with endoscopic resection: a case report. (16110853)
2005
13
Angiodysplasia of cardia of stomach--a case report. (16295381)
2004
14
Duodenal angiodysplasia: MR angiographic evaluation. (15160746)
2004
15
An unusual case of polypoid angiodysplasia. (15057704)
2004
16
Aortic stenosis and angiodysplasia in the elderly: common things occur commonly? (17670112)
2003
17
Gastrointestinal angiodysplasia and aortic stenosis. (12226167)
2002
18
A multicenter, randomized, clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia. (11677198)
2001
19
An unusual cause of acute intestinal bleeding in a young woman: angiodysplasia and Taenia saginata infestation. (9934790)
1999
20
Idiopathic immune-mediated acquired von Willebrand's disease in a patient with angiodysplasia: demonstration of an unusual inhibitor causing a functional defect and rapid clearance of von Willebrand factor. (9929110)
1999
21
Angiodysplasia of the stomach confirmed by endoscopy and selective angiography--report of a case. (9658763)
1998
22
Angiodysplasia of the gastrointestinal tract. (9113810)
1997
23
Acquired von Willebrand disease in a patient with angiodysplasia resulting from immune-mediated clearance of von Willebrand factor. (9012706)
1997
24
Lung-angiodysplasia and von Willebrand's disease in a family with Rendu-Osler disease. A case report. (9066252)
1996
25
Push enteroscopic cauterization: long-term follow-up of 83 patients with bleeding small intestinal angiodysplasia. (8781937)
1996
26
Sengstaken tube for bleeding rectal angiodysplasia. (8869319)
1996
27
Gastrointestinal angiodysplasia in congenital platelet dysfunction. (8990628)
1996
28
Angiodysplasia and lower gastrointestinal tract bleeding in elderly patients. (7717788)
1995
29
Coronary angiodysplasia causing left ventricular shunt and myocardial ischemia. (8438723)
1993
30
Angiographic localization of small bowel angiodysplasia with use of platinum coils. (8280993)
1993
31
Angiodysplasia of colon revisited: pathologic demonstration without the use of intravascular injection technique. (1544666)
1992
32
Chronic bleeding caused by small bowel angiodysplasia: a problem of recognition and diagnosis. (1421452)
1992
33
Effects of indomethacin on hepatogenic pulmonary angiodysplasia. (2009756)
1991
34
Gastrointestinal angiodysplasia. (1785223)
1991
35
Angiodysplasia associated with hypertrophic obstructive cardiomyopathy (HOCM). (2206839)
1990
36
Colonic angiodysplasia. Follow-up of patients after endoscopic treatment for bleeding lesions. (2784375)
1989
37
Estrogen-progesterone therapy for recurrent gastrointestinal bleeding secondary to gastrointestinal angiodysplasia. (3259072)
1988
38
Angiodysplasia--an uncommon cause of colonic bleeding: colonoscopic evaluation of 1,050 patients with rectal bleeding and anaemia. (3500991)
1987
39
Splenic arteriovenous fistula formation due to angiodysplasia in a splenic aneurysm of a patient with liver cirrhosis--a report of a case. (3623013)
1987
40
Gastrointestinal haemorrhage from a second source in patients with colonic angiodysplasia. (3498528)
1987
41
Angiodysplasia of the colon. (3497216)
1986
42
Angiodysplasia of the colon in patients with hemostatic defects: risk of secondary hemorrhage after electrocoagulation treatment. (6332559)
1984
43
Plain radiographic, nuclear medicine and angiographic observations of hepatogenic pulmonary angiodysplasia. (6223268)
1983
44
Acquired angiodysplasia as a cause of gastric hemorrhage: a possible consequence of cholesterol embolization. (6601457)
1983
45
Detection of bleeding from angiodysplasia of the jejunum by blood pool scintigraphy. (6303668)
1983
46
Angiodysplasia and Meckel's diverticulum: a congenital association? (6980681)
1982
47
Angiodysplasia of the colon. Experience of 26 cases. (6123752)
1982
48
Lower GI bleeding in the elderly. Diverticulosis and angiodysplasia as dominant causes. (6784109)
1981
49
Angiodysplasia of the small bowel: a method of intraoperative identification. (82441)
1978
50
Angiodysplasia of the colon: diagnosis and treatment. (299743)
1977

Genetic Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiodysplasia

Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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4Cell Signaling Technology, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Angiodysplasia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Angiodysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1aspartate4410.4SCT
2heparin44 28 11 2413.3VEGFA
3matrigel4410.3SERPINE1
4serine4410.1SCT, ACVRL1
5dexamethasone44 49 28 1113.0ENG, VEGFA
6gelofusine4410.0SST, VWF
7taurodeoxycholate449.9SST, SCT
8lafutidine449.9SST, SCT
9loxiglumide449.9SCT, SST
1011-dehydrothromboxane b2449.8SERPINE1, VWF
11prostaglandin j2449.7VEGFA, SERPINE1
12quinapril44 1110.7SERPINE1, VWF
13oxyntomodulin44 5910.6SCT, SST
14tinzaparin44 1110.6VWF, F3
15hydroxyethyl starch449.6F3, VWF
16n(g)-nitro-l-arginine methyl ester449.6F3
17ppack449.5VWF, F3
18tirofiban44 1110.5F3, VWF
19anisodamine449.5F3, SERPINE1
20tgf beta1449.4SERPINE1, ENG, ACVRL1
21hyaluronic acid44 2410.4VWF, VEGFA, ENG
22octreotide44 59 28 1112.4SCT, VEGFA, SST
23perindopril44 49 1111.4VEGFA, SERPINE1, VWF
24thyroxine44 2410.3SST, SCT, VWF
25sodium nitroprusside449.3SERPINE1, SST, VWF
26c-peptide449.3SCT, SST, SERPINE1
27atorvastatin44 49 28 11 2413.3SERPINE1, VWF, VEGFA
28ticlopidine44 1110.2VWF, F3
29epsilon aminocaproic acid449.2F3, SERPINE1
30tranexamic acid44 1110.1F3, SERPINE1, VWF
31desmopressin44 59 28 1112.1F3, VWF, SERPINE1
32hirudin449.1SERPINE1, VWF, F3
33dipyridamole44 59 28 1112.0F3, VWF, SERPINE1
34phosphatidylserine44 28 1111.0VWF, ENG, F3
35kininogen449.0VWF, F3, SERPINE1
36aprotinin44 1110.0VWF, SERPINE1, F3
37fluoxetine49 44 28 1112.0SCT, F3, SERPINE1
38homocysteine44 2410.0F3, VWF, SERPINE1
39oligonucleotide449.0ACVRL1, ENG, VWF, SCT
40ristocetin448.9VWF, F3
41isoproterenol44 119.9VWF, SCT, SST, SERPINE1
42adenylate448.8SCT, SST, SERPINE1, VWF
43epinephrine44 11 2410.7F3, VWF, SST, SCT
44testosterone44 59 11 2411.7SCT, SST, SERPINE1, VWF
45aspirin44 49 28 2411.6SERPINE1, F3, VWF
46simvastatin44 49 59 28 11 2413.5SERPINE1, F3, VWF, VEGFA
47cyclophosphamide44 49 1110.5F3, SST, SERPINE1, VWF
48prostacyclin448.5VWF, SERPINE1, VEGFA, F3
49retinoic acid44 249.0SERPINE1, VWF, F3, SST, SCT
50vegf447.3SERPINE1, VWF, ACVRL1, ENG, SST, VEGFA

GO Terms for genes affiliated with Angiodysplasia

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16Gene Ontology
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Cellular components related to Angiodysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0SERPINE1, VWF, VEGFA
2extracellular matrixGO:0310128.3SERPINE1, VWF, F3
3cell surfaceGO:0099868.3VEGFA, F3, ACVRL1, ENG
4extracellular regionGO:0055767.9VEGFA, SST, VWF, SERPINE1, SCT
5extracellular spaceGO:0056157.6VEGFA, SST, F3, SERPINE1, ENG

Biological processes related to Angiodysplasia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of BMP signaling pathwayGO:0305139.9ENG, ACVRL1
2chronological cell agingGO:0013009.8ENG, SERPINE1
3artery morphogenesisGO:0488449.8ENG, VEGFA
4negative regulation of endothelial cell proliferationGO:0019379.7ACVRL1, ENG
5patterning of blood vesselsGO:0015699.6ENG, VEGFA
6positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.5ENG, ACVRL1
7negative regulation of cell migrationGO:0303369.4ENG, SERPINE1, ACVRL1
8positive regulation of positive chemotaxisGO:0509279.4VEGFA, F3
9transforming growth factor beta receptor signaling pathwayGO:0071799.4ENG, SERPINE1, ACVRL1
10platelet degranulationGO:0025769.2VEGFA, VWF, SERPINE1
11angiogenesisGO:0015259.1VEGFA, ACVRL1, SERPINE1
12positive regulation of endothelial cell proliferationGO:0019389.1ACVRL1, F3, VEGFA
13platelet activationGO:0301689.0VEGFA, VWF, SERPINE1
14positive regulation of angiogenesisGO:0457668.8SERPINE1, F3, VEGFA
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.6ENG, SERPINE1, ACVRL1, VEGFA
16blood coagulationGO:0075968.3VEGFA, F3, VWF, SERPINE1

Molecular functions related to Angiodysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta-activated receptor activityGO:0050249.8ENG, ACVRL1
2activin bindingGO:0481859.7ENG, ACVRL1
3transforming growth factor beta bindingGO:0504319.5ENG, ACVRL1
4protease bindingGO:0020208.6SERPINE1, VWF, F3

Products for genes affiliated with Angiodysplasia

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Sources for Angiodysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet