MCID: ANG011
MIFTS: 39

Angiodysplasia malady

Gastrointestinal diseases, Cardiovascular diseases categories

Aliases & Classifications for Angiodysplasia

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 59SNOMED-CT, 27ICD10
See all sources

Aliases & Descriptions for Angiodysplasia:

Name: Angiodysplasia 10 47 12 65 36
Angiodysplasia of Stomach and Duodenum with Hemorrhage 10
 
Angiodysplasia of Colon 65


Classifications:



External Ids:

Disease Ontology10 DOID:2494
MeSH36 D016888
SNOMED-CT59 71072006
ICD1027 K55.2

Summaries for Angiodysplasia

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Wikipedia:68 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards based summary: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to vascular disease and gastric antral vascular ectasia. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways are Id Signaling Pathway and Cell adhesion_Plasmin signaling. Affiliated tissues include colon, small intestine and liver, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:10 A vascular disease that is characterized as a small vascular malformation of the gut.

Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease29.6ENG, FGF2, VEGFA, VWF
2gastric antral vascular ectasia28.5ACVRL1, CADPS, ENG, FGF2, SCT, SST
3von willebrand's disease10.6
4duodenitis10.3
5angiodysplasia of intestine10.3
6hereditary hemorrhagic telangiectasia10.3
7crohn's disease10.2VEGFA, VWF
8allescheriosis10.2VEGFA, VWF
9meckel's diverticulum10.2
10cardiomyopathy10.2
11chronic venous leg ulcers10.2FGF2, VEGFA
12liver lymphoma10.2VEGFA, VWF
13warty dyskeratoma10.2FGF2, VEGFA
14heart lymphoma10.2FGF2, VEGFA
15intraocular lymphoma10.1VEGFA, VWF
16adrenal rest tumor10.1FGF2, VEGFA
17brain sarcoma10.1FGF2, SCT
18anterior cranial fossa meningioma10.1VEGFA, VWF
19pericarditis10.1FGF2, VEGFA
20greenberg skeletal dysplasia10.1
21deficiency anemia10.1
22hemangioma10.1
23myelofibrosis10.1
24arteriovenous malformation10.1
25ainhum10.1
26esophagitis10.1
27ischemia10.1
28acquired von willebrand syndrome10.1
29splenomegaly10.1
30vascular malformation10.1
31endotheliitis10.1
32corneal ulcer10.1FGF2, VEGFA
33endometrial stromal tumor10.1FGF2, VEGFA
34pulmonary artery agenesis10.1ACVRL1, ENG
35vcl-related familial hypertrophic cardiomyopathy10.1ACVRL1, ENG
36tufted hair folliculitis10.1ACVRL1, ENG
37cervical adenoid basal carcinoma10.0FGF2, VEGFA, VWF
38hidrotic ectodermal dysplasia 210.0ACVRL1, ENG
39chronic mountain sickness10.0SST, VEGFA
40duodenal obstruction10.0SCT, SST
41glucose-6-phosphate translocase deficiency10.0SCT, SST
42fuhrmann syndrome10.0FGF2, VEGFA
43hyperinsulinemic hypoglycemia, familial, 210.0SCT, SST
44micropapillary variant infiltrating bladder urothelial carcinoma10.0SCT, SST
45skull base neoplasm10.0SST, VWF
46allergic bronchopulmonary aspergillosis10.0SCT, SST
47tertiary neurosyphilis10.0ACVRL1, ENG
48bile duct cystadenocarcinoma10.0SCT, SST
49secondary progressive multiple sclerosis10.0SCT, SST
50lung giant cell carcinoma10.0SCT, SST

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Symptoms for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 4, Phase 2, Phase 39577439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro
2
Octreotideapproved, investigationalPhase 2, Phase 319183150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
 
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Ocphyl
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide acetate
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatin
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
3
SomatostatinPhase 2, Phase 314151110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
4
PomalidomideapprovedPhase 19819171-19-8
Synonyms:
 
Pomalyst
5ColaNutraceutical1690

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Capsule Endoscopy vs Standard of Care for Obscure Intestinal BleedingRecruitingNCT00694954Phase 4
2Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical TrialCompletedNCT01601639Phase 3
3Cyrotherapy vs. APC in GAVECompletedNCT00587405Phase 2, Phase 3
4Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Small Bowel AngiodysplasiasRecruitingNCT02384122Phase 2, Phase 3
5Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment FailureCompletedNCT02622906Phase 2
6Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular MalformationCompletedNCT00964496Phase 2
7Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal BleedingCompletedNCT00389935Phase 2
8Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I StudyNot yet recruitingNCT02287558Phase 1
9Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam CapsuleCompletedNCT01820182
10Study of Hemospray for Lower Gastrointestinal HemorrhageRecruitingNCT02099435
11Prophylactic Elective Clipping of Colonic DiverticulaNot yet recruitingNCT02094456

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Cochrane evidence based reviews: Angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

33
Colon, Small intestine, Liver, Lung, Endothelial, Bone, Tongue

Animal Models for Angiodysplasia or affiliated genes

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MGI Mouse Phenotypes related to Angiodysplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.4ACVRL1, CADPS, ENG, FGF2, SCT, SST
2MP:00036316.1ACVRL1, CADPS, ENG, FGF2, SCT, SST

Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50)    (show all 420)
idTitleAuthorsYear
1
eComment. Doctor Jekyll and Mr Heyde: a vague association between angiodysplasia and aortic stenosis. (25417216)
2014
2
Angiodysplasia in patient with chronic kidney disease. (23374531)
2013
3
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (23661527)
2013
4
Clinical genetics in endoscopy: a two-question diagnosis in a patient with gastrointestinal angiodysplasia. (23362958)
2013
5
Role of vascular endothelial growth factor in angiodysplasia: an interventional study with thalidomide. (22098296)
2012
6
Successful treatment of bleeding gastro-intestinal angiodysplasia in hereditary haemorrhagic telangiectasia with thalidomide. (22674103)
2011
7
Angiodysplasia of the gallbladder. (22096745)
2011
8
Von Willebrand disease, angiodysplasia and atorvastatin. (19995387)
2010
9
Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association. (19216082)
2009
10
The mechanisms of thalidomide in treatment of angiodysplasia due to hypoxia]. (19576118)
2009
11
Diffuse colorectal angiodysplasia misdiagnosed preoperatively as ulcerative colitis in a child: report of a case. (18668317)
2008
12
Von Willebrand disease and angiodysplasia responding to atorvastatin. (18510690)
2008
13
A hypervascular pseudotumor in the liver with angiodysplasia in the center of the lesion: a new entity or a variant of focal nodular hyperplasia? (17652535)
2007
14
Long-term efficacy of octreotide in the prevention of recurrent bleeding from gastrointestinal angiodysplasia. (17311647)
2007
15
Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. (17024322)
2006
16
Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management. (16020106)
2005
17
Pedunculated angiodysplasia of the colon treated with endoscopic resection: a case report. (16110853)
2005
18
Role of hemoclips in a patient with cecal angiodysplasia at high risk of recurrent bleeding from antithrombotic therapy to maintain coronary stent patency: a case report. (16111979)
2005
19
Endoscopic detachable mini-loop ligation for treatment of gastroduodenal angiodysplasia: case study of 11 patients with long-term follow-up. (14997147)
2004
20
Angiodysplasia as a cause of gastrointestinal bleeding in childhood. (14747971)
2004
21
Colonic polypoid angiodysplasia. (12838229)
2003
22
Aortic stenosis and angiodysplasia in the elderly: common things occur commonly? (17670112)
2003
23
Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy. (12889571)
2003
24
Pedunculated angiodysplasia of the colon successfully treated with endoscopy: a new type of angiodysplasia. (12665782)
2003
25
Gastrointestinal angiodysplasia and aortic stenosis. (12226167)
2002
26
Selective angiographic catheterisation for jejunal angiodysplasia. (11222835)
2001
27
Angiodysplasia with osteohypertrophy affecting the oromaxillofacial area: clinical findings. (11572256)
2001
28
Migrating site of bleeding in a right colon demonstrating angio-dysplasia following a segmental resection of the colon. A unique variant of angiodysplasia. (11124566)
2000
29
Increased plasma vascular endothelial growth factor levels in patients with angiodysplasia. (10971796)
2000
30
Multiple jejunal angiodysplasia detected by enema-helical CT. (11124471)
2000
31
Type 2B von Willebrand's disease and angiodysplasia. (10595657)
1999
32
Is there a role for parathormone in the pathogenesis of colonic angiodysplasia? (9568887)
1998
33
Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia. (8898427)
1996
34
Angiodysplasia and lower gastrointestinal tract bleeding in elderly patients. (7717788)
1995
35
Small bowel angiodysplasia: usefulness of peroperative enteroscopy. (8513166)
1993
36
Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link? (1351610)
1992
37
Catheter-guided intraoperative localization of a jejunal angiodysplasia using the Tracker-18 coaxial catheter system: case report. (1756554)
1991
38
Hormonal therapy for bleeding from angiodysplasia: chronic renal failure, et al?? (2252035)
1990
39
A rare case of angiodysplasia: penetration of inguinal lymph nodes by large superficial leg veins. Report of five cases. (2114699)
1990
40
Angiodysplasia: current concepts. (3054852)
1988
41
Angiodysplasia in transposed colon. (3260769)
1988
42
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
43
Angiodysplasia in a colonic polyp. (3706089)
1986
44
Aortic stenosis associated with angiodysplasia. (2870037)
1986
45
Renal failure and angiodysplasia of the colon. (3873889)
1985
46
Acquired angiodysplasia. (6606356)
1983
47
Plain radiographic, nuclear medicine and angiographic observations of hepatogenic pulmonary angiodysplasia. (6223268)
1983
48
Angiodysplasia. (6118730)
1981
49
Congenital angiodysplasia with skeletal affection. (7368842)
1980
50
Gastrointestinal bleeding, angiodysplasia of the colon and acquired von Willebrand's disease. (6968610)
1980

Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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Pathways related to Angiodysplasia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ACVRL1, VEGFA
29.4FGF2, VEGFA
39.4FGF2, VEGFA
49.4FGF2, VEGFA
59.4FGF2, VEGFA
6
Angiogenesis (WikiPathways)
Show member pathways
9.4FGF2, VEGFA
79.1FGF2, VEGFA, VWF

GO Terms for genes affiliated with Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.2VEGFA, VWF
2extracellular spaceGO:00056157.6ENG, FGF2, SCT, SST, VEGFA
3extracellular regionGO:00055767.4FGF2, SCT, SST, VEGFA, VWF

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.2ACVRL1, ENG
2lymphangiogenesisGO:000194610.2ACVRL1, VEGFA
3negative regulation of endothelial cell proliferationGO:000193710.1ACVRL1, ENG
4negative regulation of blood vessel endothelial cell migrationGO:004353710.1ACVRL1, FGF2
5artery morphogenesisGO:004884410.1ENG, VEGFA
6vasculogenesisGO:000157010.0ENG, VEGFA
7positive regulation of BMP signaling pathwayGO:003051310.0ACVRL1, ENG
8cell migration involved in sprouting angiogenesisGO:000204210.0FGF2, VEGFA
9positive regulation of blood vessel endothelial cell migrationGO:004353610.0FGF2, VEGFA
10positive regulation of cell divisionGO:005178110.0FGF2, VEGFA
11positive regulation of endothelial cell migrationGO:00105959.9FGF2, VEGFA
12positive regulation of epithelial cell proliferationGO:00506799.9FGF2, VEGFA
13positive chemotaxisGO:00509189.7FGF2, VEGFA
14positive regulation of MAP kinase activityGO:00434069.5FGF2, VEGFA
15patterning of blood vesselsGO:00015699.5ENG, VEGFA
16blood vessel morphogenesisGO:00485149.3ACVRL1, VEGFA
17positive regulation of protein phosphorylationGO:00019349.3ENG, FGF2, VEGFA
18positive regulation of endothelial cell proliferationGO:00019389.3ACVRL1, FGF2, VEGFA
19positive regulation of angiogenesisGO:00457669.1ACVRL1, FGF2, VEGFA
20angiogenesisGO:00015258.9ACVRL1, ENG, FGF2, VEGFA
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.6ACVRL1, ENG, FGF2, VEGFA

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1activin bindingGO:004818510.0ACVRL1, ENG
2transforming growth factor beta-activated receptor activityGO:00050249.9ACVRL1, ENG
3chemoattractant activityGO:00420569.4FGF2, VEGFA
4transforming growth factor beta bindingGO:00504319.4ACVRL1, ENG

Sources for Angiodysplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet