MCID: ANG011
MIFTS: 50

Angiodysplasia malady

Gastrointestinal diseases category

Summaries for Angiodysplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to von willebrand's disease and hypertension. An important gene associated with Angiodysplasia is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are TGF-beta/Smad Signaling and HIF-1-alpha transcription factor network. The compounds aspartate and heparin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Angiodysplasia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

angiodysplasia 8 10 44 60
angiodysplasia of stomach and duodenum with hemorrhage 8


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Disease Ontology8 DOID:2494
SNOMED-CT56 71072006
MeSH34 D016888

Related Diseases for Angiodysplasia

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17GeneCards, 18GeneDecks
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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1von willebrand's disease30.8F3, VWF
2hypertension30.4SERPINE1
3hereditary hemorrhagic telangiectasia30.2ENG, ACVRL1
4hemangioma30.0VEGFA
5arteriovenous malformation30.0ACVRL1, ENG
6ischemia30.0VEGFA, ENG
7colon cancer29.8ENG, VEGFA
8lung cancer29.8SST, VEGFA
9hemorrhagic disease29.8VWF, F3
10deficiency anemia29.7F3, ENG, VWF
11vascular disease29.7VEGFA, F3, VWF
12adenocarcinoma29.7ENG, SCT, SST, VEGFA
13liver cirrhosis29.7SCT, F3, SST
14angiodysplasia of intestine10.5
15duodenitis10.2
16aortic disease10.2
17aortic valve stenosis10.2
18bernard-soulier syndrome10.2
19klippel-trenaunay syndrome10.1
20meckel's diverticulum10.1
21colonic disease10.1
22renal agenesis10.0
23ainhum10.0
24portal hypertension10.0
25gastric antral vascular ectasia10.0
26hypertrophic cardiomyopathy10.0
27esophagitis10.0
28myelofibrosis10.0
29renal hypertension10.0
30image syndrome10.0
31primary pulmonary hypertension10.0ACVRL1
32sickle cell disease10.0VWF
33osteoarthritis10.0ENG
34hypothyroidism10.0VWF
35intracranial aneurysm10.0ENG
36leukemia10.0ENG
37hyperparathyroidism10.0SCT
38hemolytic-uremic syndrome10.0VWF
39angiosarcoma10.0VWF
40asthma10.0SCT
41varicose veins10.0SST
42retinal vein occlusion10.0VEGFA
43blindness10.0VEGFA
44central retinal vein occlusion10.0VEGFA
45hyperthyroidism10.0SST
46neuroendocrine tumor10.0SST
47meningioma10.0SST
48diarrhea10.0SST
49age related macular degeneration10.0VEGFA
50pituitary adenoma10.0SST

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Clinical Features for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angiodysplasia

Drug clinical trials:

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Search NIH Clinical Center for Angiodysplasia

Search CenterWatch for Angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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32MalaCards
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MalaCards organs/tissues related to Angiodysplasia:

32
Colon, Small intestine, Liver, Endothelial, Lung, Tongue, Bone, Kidney, Lymph node, Appendix

Animal Models for Angiodysplasia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiodysplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.9ENG, ACVRL1, F3
2MP:00053768.8SERPINE1, ACVRL1, VWF, SCT
3MP:00028737.6VEGFA, SST, F3, ACVRL1, ENG
4MP:00053977.3VEGFA, F3, VWF, ACVRL1, SERPINE1, ENG
5MP:00053787.3ENG, SERPINE1, ACVRL1, F3, SST, VEGFA
6MP:00036317.1SCT, VEGFA, SST, F3, VWF, ACVRL1

Publications for Angiodysplasia

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50PubMed
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Articles related to Angiodysplasia:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (23661527)
2013
2
Long-acting somatostatin analogues decrease blood transfusion requirements in patients with refractory gastrointestinal bleeding associated with angiodysplasia. (22831465)
2012
3
Endoscopic removal of a bleeding colonic polypoid angiodysplasia: case report. (21086949)
2010
4
Risk factors for recurrence of acute gastrointestinal bleeding from angiodysplasia. (19512936)
2009
5
Gastrointestinal angiodysplasia in chronic renal failure. (18711303)
2008
6
Confocal fluorescence microscopy for detection of gastric angiodysplasia. (17611888)
2007
7
The Olympus EVIS LUCERA variable indices of haemoglobin chart function: a novel technique for establishing the completeness of vascular mucosal ablation in colonic angiodysplasia. (16429372)
2006
8
Bilateral renal agenesis, cerebral angiodysplasia and esophageal atresia. (16413214)
2006
9
Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management. (16020106)
2005
10
Judicious usage of estrogen/progesterone for angiodysplasia. (15644090)
2005
11
Silent angiodysplasia and occult haemobilia as rare but treatable causes of refractory iron deficiency--two case reports. (16321810)
2005
12
Radiology case of the month. Hematochezia in an unstable patient. Acute lower gastrointestinal hemorrhage secondary to angiodysplasia. (15688667)
2004
13
Pedunculated angiodysplasia of the colon successfully treated with endoscopy: a new type of angiodysplasia. (12665782)
2003
14
Embolotherapy for small bowel angiodysplasia. (14595328)
2003
15
Angiodysplasia of upper gastrointestinal tract with coagulopathy. (14700496)
2003
16
Gastric angiodysplasia in patients undergoing maintenance dialysis. (14763050)
2003
17
Bleeding Angiodysplasia of the Colon. (12003717)
2002
18
Angiodysplasia with osteohypertrophy affecting the oromaxillofacial area: clinical findings. (11572256)
2001
19
Long-acting octreotide is effective in controlling rebleeding angiodysplasia of the gastrointestinal tract. (11432511)
2001
20
Migrating site of bleeding in a right colon demonstrating angio-dysplasia following a segmental resection of the colon. A unique variant of angiodysplasia. (11124566)
2000
21
An imaging evaluation of angiodysplasia syndromes. (11191656)
2000
22
Images in focus. Carcinoma with unknown primary tumor syndrome with mucosal metastasis in the duodenum mimicking angiodysplasia. (10917197)
2000
23
Renovascular hypertension due to angiodysplasia. (11109876)
2000
24
Type 2B von Willebrand's disease and angiodysplasia. (10595657)
1999
25
Intestinal haemorrhage associated with colonic vascular ectasia (angiodysplasia) in a dog. (10092039)
1999
26
Apparent deficiency of mucosal vascular collagen type IV associated with angiodysplasia of the colon. (9577365)
1998
27
Reversal of aortic stenosis, bleeding gastrointestinal angiodysplasia, and von Willebrand syndrome by aortic valve replacement. (8596401)
1996
28
Segmental arterial calcification and atheromatosis in a limb with venous angiodysplasia (Klippel-Trenaunay syndrome). (8795308)
1996
29
Angiodysplasia of the colon in children. (7722835)
1995
30
Angiodysplasia of the colon mimicking adenocarcinoma. (8456694)
1993
31
Endoscopic Doppler in diagnosis and therapy of angiodysplasia. (8491146)
1993
32
Transluminal ligation of bleeding angiodysplasia of the small bowel without need for surgical resection. (8261838)
1993
33
Bleeding angiodysplasia of the gastrointestinal tract. (1315510)
1992
34
Angiodysplasia as a source of intestinal bleeding: report of seven cases. (1363213)
1992
35
Bleeding ectatic vascular lesion involving the sigmoid colon, endoscopically indistinguishable from angiodysplasia, in an 8-yr-old boy. (1986535)
1991
36
Cessation of gastrointestinal bleeding from angiodysplasia after surgery for idiopathic hypertrophic subaortic stenosis. (1990774)
1991
37
Jejunal angiodysplasia presenting as intestinal perforation. (2756994)
1989
38
Prolonged remission after life-threatening gastrointestinal hemorrhage from coexistent angiodysplasia and acquired bleeding diathesis. (3257645)
1988
39
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
40
Hepatogenic pulmonary angiodysplasia treated with coil-spring embolization. (3581942)
1987
41
Infantile hemorrhagic angiodysplasia. (3502423)
1987
42
Transcatheter embolization of angiodysplasia of the rectum. Report of a case. (3878664)
1985
43
Angiodysplasia of the left colon. (3874824)
1985
44
Angiodysplasia. Clinical presentation and colonoscopic diagnosis. (6609803)
1984
45
Angiodysplasia of the colon: a post-mortem study. (6982972)
1982
46
Angiodysplasia. (6118529)
1981
47
Intraoperative angiography in intestinal angiodysplasia. (6970992)
1981
48
Gastric angiodysplasia in an elderly man. (6974782)
1981
49
Acquired von Willebrand's disease, platelet-release defect and angiodysplasia. (308316)
1978
50
Cardiac disease and recurrent gastrointestinal bleeding: angiodysplasia with accompanying hypertrophic subaortic stenosis. (305604)
1977

Genetic Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiodysplasia

Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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4Cell Signaling Technology, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Angiodysplasia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Angiodysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1aspartate4410.4SCT
2heparin44 28 11 2413.3VEGFA
3matrigel4410.3SERPINE1
4serine4410.1SCT, ACVRL1
5dexamethasone44 49 28 1113.0ENG, VEGFA
6gelofusine4410.0SST, VWF
7taurodeoxycholate449.9SST, SCT
8lafutidine449.9SST, SCT
9loxiglumide449.9SCT, SST
1011-dehydrothromboxane b2449.8SERPINE1, VWF
11prostaglandin j2449.7VEGFA, SERPINE1
12quinapril44 1110.7SERPINE1, VWF
13oxyntomodulin44 5910.6SCT, SST
14tinzaparin44 1110.6VWF, F3
15hydroxyethyl starch449.6F3, VWF
16n(g)-nitro-l-arginine methyl ester449.6F3
17ppack449.5VWF, F3
18tirofiban44 1110.5F3, VWF
19anisodamine449.5F3, SERPINE1
20tgf beta1449.4SERPINE1, ENG, ACVRL1
21hyaluronic acid44 2410.4VWF, VEGFA, ENG
22octreotide44 59 28 1112.4SCT, VEGFA, SST
23perindopril44 49 1111.4VEGFA, SERPINE1, VWF
24thyroxine44 2410.3SST, SCT, VWF
25sodium nitroprusside449.3SERPINE1, SST, VWF
26c-peptide449.3SCT, SST, SERPINE1
27atorvastatin44 49 28 11 2413.3SERPINE1, VWF, VEGFA
28ticlopidine44 1110.2VWF, F3
29epsilon aminocaproic acid449.2F3, SERPINE1
30tranexamic acid44 1110.1F3, SERPINE1, VWF
31desmopressin44 59 28 1112.1F3, VWF, SERPINE1
32hirudin449.1SERPINE1, VWF, F3
33dipyridamole44 59 28 1112.0F3, VWF, SERPINE1
34phosphatidylserine44 28 1111.0VWF, ENG, F3
35kininogen449.0VWF, F3, SERPINE1
36aprotinin44 1110.0VWF, SERPINE1, F3
37fluoxetine49 44 28 1112.0SCT, F3, SERPINE1
38homocysteine44 2410.0F3, VWF, SERPINE1
39oligonucleotide449.0ACVRL1, ENG, VWF, SCT
40ristocetin448.9VWF, F3
41isoproterenol44 119.9VWF, SCT, SST, SERPINE1
42adenylate448.8SCT, SST, SERPINE1, VWF
43epinephrine44 11 2410.7F3, VWF, SST, SCT
44testosterone44 59 11 2411.7SCT, SST, SERPINE1, VWF
45aspirin44 49 28 2411.6SERPINE1, F3, VWF
46simvastatin44 49 59 28 11 2413.5SERPINE1, F3, VWF, VEGFA
47cyclophosphamide44 49 1110.5F3, SST, SERPINE1, VWF
48prostacyclin448.5VWF, SERPINE1, VEGFA, F3
49retinoic acid44 249.0SERPINE1, VWF, F3, SST, SCT
50vegf447.3SERPINE1, VWF, ACVRL1, ENG, SST, VEGFA

GO Terms for genes affiliated with Angiodysplasia

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16Gene Ontology
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Cellular components related to Angiodysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.0SERPINE1, VWF, VEGFA
2extracellular matrixGO:0310128.3SERPINE1, VWF, F3
3cell surfaceGO:0099868.3VEGFA, F3, ACVRL1, ENG
4extracellular regionGO:0055767.9VEGFA, SST, VWF, SERPINE1, SCT
5extracellular spaceGO:0056157.6VEGFA, SST, F3, SERPINE1, ENG

Biological processes related to Angiodysplasia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of BMP signaling pathwayGO:0305139.9ENG, ACVRL1
2chronological cell agingGO:0013009.8ENG, SERPINE1
3artery morphogenesisGO:0488449.8ENG, VEGFA
4negative regulation of endothelial cell proliferationGO:0019379.7ACVRL1, ENG
5patterning of blood vesselsGO:0015699.6ENG, VEGFA
6positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.5ENG, ACVRL1
7negative regulation of cell migrationGO:0303369.4ENG, SERPINE1, ACVRL1
8positive regulation of positive chemotaxisGO:0509279.4VEGFA, F3
9transforming growth factor beta receptor signaling pathwayGO:0071799.4ENG, SERPINE1, ACVRL1
10platelet degranulationGO:0025769.2VEGFA, VWF, SERPINE1
11angiogenesisGO:0015259.1VEGFA, ACVRL1, SERPINE1
12positive regulation of endothelial cell proliferationGO:0019389.1ACVRL1, F3, VEGFA
13platelet activationGO:0301689.0VEGFA, VWF, SERPINE1
14positive regulation of angiogenesisGO:0457668.8SERPINE1, F3, VEGFA
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.6ENG, SERPINE1, ACVRL1, VEGFA
16blood coagulationGO:0075968.3VEGFA, F3, VWF, SERPINE1

Molecular functions related to Angiodysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta-activated receptor activityGO:0050249.8ENG, ACVRL1
2activin bindingGO:0481859.7ENG, ACVRL1
3transforming growth factor beta bindingGO:0504319.5ENG, ACVRL1
4protease bindingGO:0020208.6SERPINE1, VWF, F3

Products for genes affiliated with Angiodysplasia

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Sources for Angiodysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet