MCID: ANG011
MIFTS: 44

Angiodysplasia malady

Categories: Gastrointestinal diseases, Cardiovascular diseases

Aliases & Classifications for Angiodysplasia

Aliases & Descriptions for Angiodysplasia:

Name: Angiodysplasia 12 52 42 14 69
Angiodysplasia of Stomach and Duodenum with Hemorrhage 12
Angiodysplasia of Colon 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2494
ICD9CM 35 537.83
MeSH 42 D016888
SNOMED-CT 64 71072006
ICD10 33 K55.2

Summaries for Angiodysplasia

Disease Ontology : 12 A vascular disease that is characterized as a small vascular malformation of the gut.

MalaCards based summary : Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to capillary hemangioma and angiodysplasia of intestine. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endochondral Ossification. The drugs Iron and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and endothelial, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia : 71 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

Related Diseases for Angiodysplasia

Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 capillary hemangioma 29.2 SST VEGFA
2 angiodysplasia of intestine 11.8
3 nevada syndrome 10.8
4 angioosteohypotrophic syndrome 10.8
5 degenerative disc disease 10.2 VEGFA VWF
6 aortic aneurysm 10.2 VEGFA VWF
7 von willebrand's disease 10.2
8 renal adenoma 10.2 VEGFA VWF
9 common variable immunodeficiency 10.2 FGF2 VEGFA
10 bipolar i disorder 10.2 FGF2 VEGFA
11 benign idiopathic neonatal seizures 10.2 FGF2 VEGFA
12 tumor of exocrine pancreas 10.2 FGF2 VEGFA
13 adult brain stem glioma 10.2 FGF2 SCT
14 zellweger syndrome 10.2 VEGFA VWF
15 upper respiratory tract disease 10.2 FGF2 VEGFA
16 neurilemmoma of the pleura 10.1 FGF2 VEGFA
17 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 FGF2 VEGFA
18 laryngeal adenoid cystic carcinoma 10.1 ENG VEGFA
19 retinal degeneration 10.1 ENG VEGFA
20 pulmonary surfactant protein b, deficiency of 10.1 ACVRL1 ENG
21 pulmonary venoocclusive disease 1 10.1 ACVRL1 ENG
22 ischemic optic neuropathy 10.1 VEGFA VWF
23 human granulocytic anaplasmosis 10.1 VEGFA VWF
24 x-linked leigh syndrome 10.1 ACVRL1 ENG
25 oppositional defiant disorder 10.1 FGF2 VEGFA VWF
26 joubert syndrome and related disorders 10.1 ACVRL1 ENG
27 oculocutaneous albinism 10.1 SST VEGFA
28 ectodermal dysplasia 9, hair/nail type 10.0 SST VEGFA
29 gmppa-cdg 10.0 SCT SST
30 tricuspid valve stenosis 10.0 SCT SST
31 peripheral degeneration of cornea 10.0 SCT SST
32 iga glomerulonephritis 10.0 ENG FGF2
33 progressive relapsing multiple sclerosis 10.0 SCT SST
34 gemistocytic astrocytoma 10.0 SCT SST
35 tabes dorsalis 10.0 SCT SST
36 acute pyelonephritis 10.0 SCT SST
37 cardioauditory syndrome of sanchez cascos 10.0 SST VEGFA
38 maturity-onset diabetes of the young, type 13 10.0 SCT SST
39 urinary bladder posterior wall cancer 10.0 ACVRL1 FGF2 VEGFA
40 subdural empyema 10.0 FGF2 VEGFA
41 short bowel syndrome 10.0 SCT SST
42 eccrine papillary adenocarcinoma 10.0 SCT SST
43 glycerol kinase deficiency, adult form 10.0 ENG FGF2 VEGFA
44 cervical alveolar soft part sarcoma 9.9 SST VWF
45 respiratory syncytial virus infectious disease 9.9 ACVRL1 ENG VEGFA
46 pituitary infarct 9.9 ACVRL1 ENG VEGFA
47 fiedler's myocarditis 9.9 SST VEGFA VWF
48 rheumatic encephalitis 9.9 SST VEGFA
49 metagonimiasis 9.9 FGF2 VEGFA
50 benign shuddering attacks 9.9 SCT SST VEGFA

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to Angiodysplasia

Symptoms & Phenotypes for Angiodysplasia

MGI Mouse Phenotypes related to Angiodysplasia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ACVRL1 CADPS ENG FGF2 SST VEGFA
2 digestive/alimentary MP:0005381 9.65 ENG SST VEGFA VWF ACVRL1
3 mortality/aging MP:0010768 9.5 ACVRL1 CADPS ENG FGF2 SST VEGFA
4 nervous system MP:0003631 9.17 ACVRL1 CADPS ENG FGF2 SST VEGFA

Drugs & Therapeutics for Angiodysplasia

Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2,Phase 3 7439-89-6 23925
2
Somatostatin Approved Phase 2, Phase 3 38916-34-6, 51110-01-1 53481605
3
Octreotide Approved, Investigational Phase 2, Phase 3 83150-76-9 383414 6400441
4
Proton pump inhibitors Phase 2, Phase 3
5 Antineoplastic Agents, Hormonal Phase 2, Phase 3
6 Gastrointestinal Agents Phase 2, Phase 3
7 Angiogenesis Inhibitors Phase 2,Phase 1
8 Angiogenesis Modulating Agents Phase 2,Phase 1
9 Anti-Bacterial Agents Phase 2,Phase 1
10 Anti-Infective Agents Phase 2,Phase 1
11 Immunosuppressive Agents Phase 2,Phase 1
12 Hormone Antagonists Phase 2
13 Hormones Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
15 Pomalidomide Approved Phase 1 19171-19-8
16
Infliximab Approved 170277-31-3
17 Hemostatics
18 Cola Nutraceutical

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding Unknown status NCT00694954 Phase 4
2 Cyrotherapy vs. APC in GAVE Completed NCT00587405 Phase 2, Phase 3
3 Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical Trial Completed NCT01601639 Phase 3
4 Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Angiodysplasias Recruiting NCT02384122 Phase 2, Phase 3
5 Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure Completed NCT02622906 Phase 2
6 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation Completed NCT00964496 Phase 2
7 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2
8 Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding Withdrawn NCT02754960 Phase 2
9 Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I Study Unknown status NCT02287558 Phase 1
10 Study of Hemospray for Lower Gastrointestinal Hemorrhage Completed NCT02099435
11 Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule Completed NCT01820182
12 Prophylactic Elective Clipping of Colonic Diverticula Recruiting NCT02094456

Search NIH Clinical Center for Angiodysplasia

Cochrane evidence based reviews: angiodysplasia

Genetic Tests for Angiodysplasia

Anatomical Context for Angiodysplasia

MalaCards organs/tissues related to Angiodysplasia:

39
Colon, Small Intestine, Endothelial, Liver, Lung, Bone, Appendix

Publications for Angiodysplasia

Articles related to Angiodysplasia:

(show top 50) (show all 442)
id Title Authors Year
1
Gastrointestinal Angiodysplasia: Diagnosis and Management. ( 27908518 )
2017
2
Intractable anemia due to extensive refractory angiodysplasia of the small intestine stabilized by an anti-angiogenic agent. ( 28062159 )
2017
3
Hemodialysis Switch Improved Colonic Angiodysplasia in a Peritoneal Dialysis Patient. ( 27659936 )
2016
4
Risk factors for active bleeding from colonic angiodysplasia confirmed by colonoscopic observation. ( 27596107 )
2016
5
Endothelial dysfunction in von Willebrand disease: angiogenesis and angiodysplasia. ( 27207426 )
2016
6
Multiple Polypoid Angiodysplasia with Obscure Overt Bleeding. ( 26855931 )
2016
7
Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells. ( 28003433 )
2016
8
Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono-centre trial. ( 26966525 )
2016
9
In-hospital weekend outcomes in patients diagnosed with bleedingA gastroduodenal angiodysplasia: a population-based study,A 2000 toA 2011. ( 26972023 )
2016
10
Popliteal Artery Entrapment and Fibular Angiodysplasia in Siblings. ( 27480046 )
2016
11
Hemobilia from Biliary Angiodysplasia Diagnosed with Cholangioscopy. ( 27807584 )
2016
12
Colonic Angiodysplasia with a Huge Submucosal Hematoma in the Sigmoid Colon. ( 27340585 )
2016
13
Gastrointestinal bleeding due to angiodysplasia in patients on hemodialysis: A single-center study. ( 27424692 )
2016
14
Gastrointestinal angiodysplasia is associated with significant gastrointestinal bleeding in patients with continuous left ventricular assist devices. ( 27004257 )
2016
15
Thalidomide for the treatment of angiodysplasia in a patient with acute upper gastrointestinal haemorrhage. ( 26791122 )
2016
16
Use of endoscopic-assisted argon plasma coagulation for the treatment of colonic vascular ectasia (angiodysplasia) in an adult dog. ( 26885595 )
2016
17
Analysis of risk factor and clinical characteristics of angiodysplasia presenting as upper gastrointestinal bleeding. ( 26828247 )
2016
18
Hematochezia due to Angiodysplasia of the Appendix. ( 27437394 )
2016
19
Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia? ( 27352634 )
2016
20
Thalidomide for treatment of gastrointestinal angiodysplasia in patients with left ventricular assist devices: case series and treatment protocol. ( 25447569 )
2015
21
Could a Transient Deficiency in Von Willebrand Factor be a Cause of Gastrointestinal Angiodysplasia? ( 25723359 )
2015
22
Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease. ( 26316703 )
2015
23
The natural history of small bowel angiodysplasia. ( 26540240 )
2015
24
Use of polymethylmethacrylate in treatment of arteriovenous angiodysplasia with bone lesions. ( 26355937 )
2015
25
Thalidomide in angiodysplasia-related bleeding. ( 26332623 )
2015
26
Clinical features and endoscopic findings in patients with actively bleeding colonic angiodysplasia. ( 25772855 )
2015
27
Success of Minimally Invasive Transumbilical Single-Incision Laparoscopic Surgery (T-SILS) Plus Double-Balloon Endoscopy (DBE) for Pediatric Intestinal Angiodysplasia: A Case Report. ( 26011216 )
2015
28
Jejunal angiodysplasia causing recurrent gastrointestinal bleeding presenting as severe anaemia and melena. ( 26567241 )
2015
29
Angiodysplasia: an unusual case of gastrointestinal bleeding. ( 26031261 )
2015
30
Thalidomide for treatment of gastrointestinal bleedings due to angiodysplasia: a case report in acquired von Willebrand syndrome and review of the literature. ( 25929157 )
2015
31
Argon plasma coagulation in the management of symptomatic gastrointestinal angiodysplasia: experience in 69 consecutive patients. ( 26895122 )
2015
32
eComment. Doctor Jekyll and Mr Heyde: a vague association between angiodysplasia and aortic stenosis. ( 25417216 )
2014
33
Valvular aortic stenosis causing angiodysplasia and acquired von Willebrand's disease: Heyde's syndrome. ( 24686797 )
2014
34
Gastrointestinal angiodysplasia and bleeding in von Willebrand disease. ( 24898873 )
2014
35
Genetically induced oxidative stress in mice causes thrombocytosis, splenomegaly and placental angiodysplasia that leads to recurrent abortion. ( 24936442 )
2014
36
Review article: gastrointestinal angiodysplasia - pathogenesis, diagnosis and management. ( 24138285 )
2014
37
Long acting release-octreotide as "rescue" therapy to control angiodysplasia bleeding: A retrospective study of 98 cases. ( 24893688 )
2014
38
Expression of Angiogenic Factors in Patients With Sporadic Small Bowel Angiodysplasia. ( 25319741 )
2014
39
MDCT demonstration of jejunal angiodysplasia: an uncommon cause of lower gastrointestinal haemorrhage. ( 24663251 )
2014
40
Recurrent jejunal bleeding due to angiodysplasia in a Bernard-Soulier patient. ( 23591164 )
2013
41
Von Willebrand disease-associated angiodysplasia: a few answers, still many questions. ( 23432086 )
2013
42
Medical and Endoscopic Therapies for Angiodysplasia and Gastric Antral Vascular Ectasia: A Systematic Review. ( 24013107 )
2013
43
Successful treatment with thalidomide for a patient with recurrent gastrointestinal bleeding due to angiodysplasia diagnosed by capsule endoscopy. ( 23134426 )
2013
44
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. ( 23661527 )
2013
45
Colonic vascular ectasia (angiodysplasia) in a juvenile dog. ( 23058126 )
2013
46
Combined endoclipping and argon plasma coagulation (APC)--daisy technique for cecal angiodysplasia. ( 24285060 )
2013
47
Von Willebrand Factor, Angiodysplasia and Angiogenesis. ( 24106610 )
2013
48
Clinical genetics in endoscopy: a two-question diagnosis in a patient with gastrointestinal angiodysplasia. ( 23362958 )
2013
49
Angiodysplasia and bleeding in the small intestine treated by balloon-assisted enteroscopy. ( 23216888 )
2013
50
Increased incidence of angiodysplasia of the gastrointestinal tract and bleeding in patients with continuous flow left ventricular assist devices (LVADs). ( 23897227 )
2013

Variations for Angiodysplasia

Expression for Angiodysplasia

Search GEO for disease gene expression data for Angiodysplasia.

Pathways for Angiodysplasia

GO Terms for Angiodysplasia

Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ENG FGF2 SCT SST VEGFA

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.88 ACVRL1 ENG FGF2 VEGFA
2 positive regulation of MAP kinase activity GO:0043406 9.57 FGF2 VEGFA
3 vasculogenesis GO:0001570 9.56 ENG VEGFA
4 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.55 ACVRL1 ENG
5 positive regulation of cell division GO:0051781 9.54 FGF2 VEGFA
6 positive chemotaxis GO:0050918 9.52 FGF2 VEGFA
7 positive regulation of BMP signaling pathway GO:0030513 9.51 ACVRL1 ENG
8 branching involved in blood vessel morphogenesis GO:0001569 9.49 ENG VEGFA
9 artery morphogenesis GO:0048844 9.48 ENG VEGFA
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.46 FGF2 VEGFA
11 angiogenesis GO:0001525 9.46 ACVRL1 ENG FGF2 VEGFA
12 endocardial cushion morphogenesis GO:0003203 9.43 ACVRL1 ENG
13 positive regulation of endothelial cell proliferation GO:0001938 9.43 ACVRL1 FGF2 VEGFA
14 cell migration involved in sprouting angiogenesis GO:0002042 9.4 FGF2 VEGFA
15 negative regulation of blood vessel endothelial cell migration GO:0043537 9.37 ACVRL1 FGF2
16 dorsal aorta morphogenesis GO:0035912 9.32 ACVRL1 ENG
17 endocardial cushion to mesenchymal transition GO:0090500 8.96 ACVRL1 ENG
18 positive regulation of angiogenesis GO:0045766 8.92 ACVRL1 ENG FGF2 VEGFA

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 FGF2 VEGFA
2 transforming growth factor beta binding GO:0050431 8.96 ACVRL1 ENG
3 activin binding GO:0048185 8.62 ACVRL1 ENG

Sources for Angiodysplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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