MCID: ANG011
MIFTS: 48

Angiodysplasia malady

Gastrointestinal diseases category

Summaries for Angiodysplasia

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Wikipedia:63 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

MalaCards based summary: Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to von willebrand's disease and arteriovenous malformation. An important gene associated with Angiodysplasia is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are Id Signaling Pathway and TGF Beta Signaling Pathway. The compounds gelofusine and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related mouse phenotypes are digestive/alimentary and respiratory system.

Disease Ontology:9 A vascular disease that is characterized as a small vascular malformation of the gut.

Aliases & Classifications for Angiodysplasia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 25ICD10
See all sources

Angiodysplasia, Aliases & Descriptions:

Name: Angiodysplasia 9 11 43 60
Angiodysplasia of Stomach and Duodenum with Hemorrhage 9
 
Angiodysplasia of Colon 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:2494
MeSH33 D016888
SNOMED-CT55 71072006
ICD1025 K55.2

Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1von willebrand's disease31.2VWF, F3
2arteriovenous malformation30.9ACVRL1
3hereditary hemorrhagic telangiectasia30.8ACVRL1, ENG
4glucagonoma30.2SST, SCT
5thrombocytosis30.1F3, VWF
6deficiency anemia29.9F3, ENG, VWF
7vascular disease29.9VWF, VEGFA, F3
8liver cirrhosis29.8SST, F3, SCT
9adenocarcinoma29.6SST, ENG, VEGFA, SCT
10central retinal vein occlusion10.5VEGFA
11dumping syndrome10.4SST
12diabetic macular edema10.4VEGFA
13factor xi deficiency, autosomal recessive10.4F3
14factor viii deficiency10.4F3
15cerebral arteriovenous malformation10.4ENG, ACVRL1
16telangiectasis10.3ENG, ACVRL1
17duodenitis10.3
18vascular cancer10.3VEGFA, ENG
19hyperinsulinemic hypoglycemia, familial, 210.2SST, SCT
20angiodysplasia of intestine10.2
21connective tissue disease10.2VWF, F3
22vipoma10.2SST, SCT
23hemarthrosis10.2VWF, F3
24zollinger-ellison syndrome10.2SCT, SST
25steatorrhea10.2SST, SCT
26intracranial thrombosis10.2VWF, F3
27blood platelet disease10.2VWF, F3
28factor xii deficiency10.2F3, VWF
29atrophic gastritis10.2SCT, SST
30hemorrhagic disease10.2VWF, F3
31duodenal ulcer10.2SCT, SST
32peptic ulcer disease10.2SCT, SST
33afibrinogenemia10.2F3, VWF
34hemophilia a10.2VWF, F3
35gastrinoma10.2SST, SCT
36multiple endocrine neoplasia 110.2SST, SCT
37glanzmann thrombasthenia10.2F3, VWF
38meckel's diverticulum10.2
39antiphospholipid syndrome10.2VWF, F3
40factor vii deficiency10.1SST, VEGFA
41bone marrow cancer10.1ENG, VWF
42microvascular complications of diabetes 110.1VEGFA, SST
43hemolytic anemia10.1VWF, F3
44peripheral vascular disease10.1VWF, SERPINE1
45hellp syndrome10.1SERPINE1, VWF
46acute pancreatitis10.1SST, SCT
47renal fibrosis10.1SERPINE1, ENG
48brain disease10.1F3, VWF
49hemangioma10.1
50myelofibrosis10.1

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to angiodysplasia

Symptoms for Angiodysplasia

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Drugs & Therapeutics for Angiodysplasia

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Drug clinical trials:

Search ClinicalTrials for Angiodysplasia

Search NIH Clinical Center for Angiodysplasia

Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

31
Colon, Small intestine, Liver, Lung, Endothelial, Bone, Lymph node, Kidney, Tongue, Appendix

Animal Models for Angiodysplasia or affiliated genes

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MGI Mouse Phenotypes related to Angiodysplasia:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6ACVRL1, SST, VEGFA, VWF
2MP:00053888.4VEGFA, SERPINE1, ACVRL1, ENG
3MP:00053698.3VEGFA, F3, ACVRL1, ENG
4MP:00028738.2VEGFA, F3, SST, ACVRL1, ENG
5MP:00053857.6VWF, VEGFA, SERPINE1, F3, ACVRL1, ENG
6MP:00053877.6SST, F3, SERPINE1, VEGFA, VWF
7MP:00053977.6VWF, VEGFA, SERPINE1, F3, ACVRL1, ENG
8MP:00107687.4VWF, VEGFA, SERPINE1, F3, ACVRL1, ENG
9MP:00036317.4VWF, VEGFA, SCT, F3, SST, ACVRL1
10MP:00053787.4VEGFA, SERPINE1, F3, SST, ACVRL1, ENG
11MP:00053766.6ENG, VWF, VEGFA, SCT, SERPINE1, F3

Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50)    (show all 410)
idTitleAuthorsYear
1
eComment. Doctor Jekyll and Mr Heyde: a vague association between angiodysplasia and aortic stenosis. (25417216)
2014
2
Angiodysplasia in patient with chronic kidney disease. (23374531)
2013
3
Successful treatment of thalidomide for recurrent bleeding due to gastric angiodysplasia in hereditary hemorrhagic telangiectasia. (23661527)
2013
4
Clinical genetics in endoscopy: a two-question diagnosis in a patient with gastrointestinal angiodysplasia. (23362958)
2013
5
Role of vascular endothelial growth factor in angiodysplasia: an interventional study with thalidomide. (22098296)
2012
6
Successful treatment of bleeding gastro-intestinal angiodysplasia in hereditary haemorrhagic telangiectasia with thalidomide. (22674103)
2011
7
Angiodysplasia of the gallbladder. (22096745)
2011
8
Von Willebrand disease, angiodysplasia and atorvastatin. (19995387)
2010
9
Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association. (19216082)
2009
10
The mechanisms of thalidomide in treatment of angiodysplasia due to hypoxia]. (19576118)
2009
11
Von Willebrand disease and angiodysplasia responding to atorvastatin. (18510690)
2008
12
A hypervascular pseudotumor in the liver with angiodysplasia in the center of the lesion: a new entity or a variant of focal nodular hyperplasia? (17652535)
2007
13
Long-term efficacy of octreotide in the prevention of recurrent bleeding from gastrointestinal angiodysplasia. (17311647)
2007
14
Long-term outcome of argon plasma ablation therapy for bleeding in 100 consecutive patients with colonic angiodysplasia. (17024322)
2006
15
Gastric angiodysplasia in a child with Bernard-Soulier syndrome: efficacy of octreotide in long-term management. (16020106)
2005
16
Pedunculated angiodysplasia of the colon treated with endoscopic resection: a case report. (16110853)
2005
17
Role of hemoclips in a patient with cecal angiodysplasia at high risk of recurrent bleeding from antithrombotic therapy to maintain coronary stent patency: a case report. (16111979)
2005
18
Endoscopic detachable mini-loop ligation for treatment of gastroduodenal angiodysplasia: case study of 11 patients with long-term follow-up. (14997147)
2004
19
Angiodysplasia as a cause of gastrointestinal bleeding in childhood. (14747971)
2004
20
Colonic polypoid angiodysplasia. (12838229)
2003
21
Aortic stenosis and angiodysplasia in the elderly: common things occur commonly? (17670112)
2003
22
Somatostatin therapy ameliorates chronic and refractory gastrointestinal bleeding caused by diffuse angiodysplasia in a patient on anticoagulation therapy. (12889571)
2003
23
Pedunculated angiodysplasia of the colon successfully treated with endoscopy: a new type of angiodysplasia. (12665782)
2003
24
Gastrointestinal angiodysplasia and aortic stenosis. (12226167)
2002
25
Selective angiographic catheterisation for jejunal angiodysplasia. (11222835)
2001
26
Angiodysplasia with osteohypertrophy affecting the oromaxillofacial area: clinical findings. (11572256)
2001
27
Migrating site of bleeding in a right colon demonstrating angio-dysplasia following a segmental resection of the colon. A unique variant of angiodysplasia. (11124566)
2000
28
Increased plasma vascular endothelial growth factor levels in patients with angiodysplasia. (10971796)
2000
29
Multiple jejunal angiodysplasia detected by enema-helical CT. (11124471)
2000
30
Type 2B von Willebrand's disease and angiodysplasia. (10595657)
1999
31
Transjugular intrahepatic portosystemic shunt for bleeding angiodysplasia-like lesions in portal-hypertensive colopathy. (9649472)
1998
32
Is there a role for parathormone in the pathogenesis of colonic angiodysplasia? (9568887)
1998
33
Somatostatin in the treatment of gastrointestinal bleeding caused by angiodysplasia. (8898427)
1996
34
Angiodysplasia and lower gastrointestinal tract bleeding in elderly patients. (7717788)
1995
35
Small bowel angiodysplasia: usefulness of peroperative enteroscopy. (8513166)
1993
36
Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link? (1351610)
1992
37
Catheter-guided intraoperative localization of a jejunal angiodysplasia using the Tracker-18 coaxial catheter system: case report. (1756554)
1991
38
Hormonal therapy for bleeding from angiodysplasia: chronic renal failure, et al?? (2252035)
1990
39
A rare case of angiodysplasia: penetration of inguinal lymph nodes by large superficial leg veins. Report of five cases. (2114699)
1990
40
Angiodysplasia: current concepts. (3054852)
1988
41
Angiodysplasia in transposed colon. (3260769)
1988
42
Angiodysplasia of the colon: an expression of occlusive vascular disease. (2440788)
1987
43
Angiodysplasia in a colonic polyp. (3706089)
1986
44
Aortic stenosis associated with angiodysplasia. (2870037)
1986
45
Renal failure and angiodysplasia of the colon. (3873889)
1985
46
Acquired angiodysplasia. (6606356)
1983
47
Plain radiographic, nuclear medicine and angiographic observations of hepatogenic pulmonary angiodysplasia. (6223268)
1983
48
Angiodysplasia. (6118730)
1981
49
Congenital angiodysplasia with skeletal affection. (7368842)
1980
50
Gastrointestinal bleeding, angiodysplasia of the colon and acquired von Willebrand's disease. (6968610)
1980

Variations for Angiodysplasia

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Expression for genes affiliated with Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.

Pathways for genes affiliated with Angiodysplasia

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Compounds for genes affiliated with Angiodysplasia

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Compounds related to Angiodysplasia according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1gelofusine4310.0SST, VWF
2taurodeoxycholate439.9SST, SCT
3lafutidine439.9SCT, SST
4loxiglumide439.9SST, SCT
5tinzaparin43 1210.8F3, VWF
6hydroxyethyl starch439.7F3, VWF
7ppack439.7F3, VWF
8tirofiban43 1210.6F3, VWF
9prostaglandin j2439.5VEGFA, SERPINE1
10oxyntomodulin43 5910.5SST, SCT
1111-dehydrothromboxane b2439.5SERPINE1, VWF
12anisodamine439.5F3, SERPINE1
13hyaluronic acid43 2410.5VWF, ENG, VEGFA
14quinapril43 49 1211.4VWF, SERPINE1
15thyroxine43 2410.4SCT, VWF, SST
16octreotide43 59 28 1212.4SCT, VEGFA, SST
17tgf beta1439.2SERPINE1, ENG, ACVRL1
18phosphatidylserine43 28 1211.2F3, ENG, VWF
19perindopril43 49 1211.2VWF, VEGFA, SERPINE1
20ristocetin439.1VWF, F3
21c-peptide439.1SERPINE1, SCT, SST
22tranexamic acid43 1210.1F3, SERPINE1, VWF
23oligonucleotide439.1VWF, ENG, ACVRL1, SCT
24sodium nitroprusside439.1VWF, SERPINE1, SST
25desmopressin43 59 28 1212.1SERPINE1, F3, VWF
26hirudin439.1SERPINE1, F3, VWF
27atorvastatin43 49 28 24 1213.1VWF, VEGFA, SERPINE1
28dipyridamole43 59 28 1212.0VWF, SERPINE1, F3
29n(g)-nitro-l-arginine methyl ester439.0SERPINE1, F3
30kininogen439.0SERPINE1, F3, VWF
31aprotinin43 1210.0VWF, SERPINE1, F3
32fluoxetine43 49 28 1212.0SCT, F3, SERPINE1
33homocysteine43 2410.0F3, SERPINE1, VWF
34epsilon aminocaproic acid438.9F3, SERPINE1
35epinephrine43 24 1210.9F3, SCT, VWF, SST
36matrigel438.8ENG, VWF, SERPINE1, VEGFA
37isoproterenol43 129.7SCT, SERPINE1, VWF, SST
38aspirin43 49 28 2411.7F3, VWF, SERPINE1
39adenylate438.6SERPINE1, SCT, VWF, SST
40simvastatin43 49 59 28 24 1213.5VEGFA, VWF, SERPINE1, F3
41prostacyclin438.5F3, SERPINE1, VWF, VEGFA
42aspartate438.5VWF, SCT, SERPINE1, F3
43testosterone43 59 24 1211.5SCT, SERPINE1, SST, VWF
44heparin43 28 24 1211.4VWF, F3, SERPINE1, VEGFA
45cycloheximide438.3F3, SST, SERPINE1, VEGFA
46dexamethasone43 49 28 1211.3VEGFA, SST, ENG, VWF, SERPINE1
47retinoic acid43 249.0F3, SERPINE1, SCT, SST, VWF
48cyclophosphamide43 49 1210.0SERPINE1, VWF, F3, VEGFA, SST
49serine437.9ACVRL1, F3, SERPINE1, SCT, VWF, ENG
50vegf437.3SST, VWF, VEGFA, SERPINE1, F3, ACVRL1

GO Terms for genes affiliated with Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310938.8VWF, VEGFA, SERPINE1
2extracellular matrixGO:00310128.6F3, SERPINE1, VWF
3cell surfaceGO:00099868.6VEGFA, F3, ACVRL1, ENG
4extracellular spaceGO:00056157.5F3, SERPINE1, VEGFA, SST, ENG
5extracellular regionGO:00055767.4SERPINE1, SCT, VEGFA, VWF, SST

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of BMP signaling pathwayGO:00305139.9ACVRL1, ENG
2negative regulation of endothelial cell proliferationGO:00019379.8ACVRL1, ENG
3positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.8ENG, ACVRL1
4BMP signaling pathwayGO:00305099.8ENG, ACVRL1
5artery morphogenesisGO:00488449.7VEGFA, ENG
6chronological cell agingGO:00013009.6ENG, SERPINE1
7positive regulation of positive chemotaxisGO:00509279.6F3, VEGFA
8patterning of blood vesselsGO:00015699.5VEGFA, ENG
9positive regulation of endothelial cell proliferationGO:00019389.3VEGFA, F3, ACVRL1
10vasculogenesisGO:00015709.3VEGFA, ENG
11negative regulation of cell migrationGO:00303369.2SERPINE1, ACVRL1, ENG
12transforming growth factor beta receptor signaling pathwayGO:00071799.2ENG, SERPINE1, ACVRL1
13platelet degranulationGO:00025769.0SERPINE1, VEGFA, VWF
14angiogenesisGO:00015259.0SERPINE1, VEGFA, ACVRL1
15platelet activationGO:00301688.9VWF, VEGFA, SERPINE1
16positive regulation of angiogenesisGO:00457668.8VEGFA, F3, SERPINE1
17positive regulation of transcription from RNA polymerase II promoterGO:00459448.6SERPINE1, ENG, ACVRL1, VEGFA
18blood coagulationGO:00075968.4SERPINE1, F3, VWF, VEGFA

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:00504319.8ENG, ACVRL1
2activin bindingGO:00481859.7ENG, ACVRL1
3transforming growth factor beta-activated receptor activityGO:00050249.5ENG, ACVRL1
4protease bindingGO:00020208.6F3, SERPINE1, VWF

Products for genes affiliated with Angiodysplasia

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Sources for Angiodysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet