MCID: ANG015
MIFTS: 61

Angioedema malady

Genetic diseases, Skin diseases, Rare diseases, Bone diseases, Immune diseases categories
Download this MalaCard

Summaries for Angioedema

About this section


Fully expand this MalaCard
Disease Ontology:8 A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues.

MalaCards based summary: Angioedema, also known as angioneurotic edema, is related to hereditary angioedema and c1 inhibitor deficiency. An important gene associated with Angioedema is SERPING1 (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1), and among its related pathways are Cell adhesion Plasmin signaling and Pertussis. The drug fluoxymesterone and the compounds zofenoprilat and enalaprilate have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and testes.

Wikipedia:65 Angioedema (BE: angiooedema) or Quincke\'s edema is the rapid swelling (edema) of the dermis,... more...

Aliases & Classifications for Angioedema

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Angioedema, Aliases & Descriptions:

Name: Angioedema 8 10 44 62
Angioneurotic Edema 8 62
Quincke's Edema 8 62
 
Angioneurotic Oedema 8
Urticaria, Giant 62
Giant Urticaria 8


Classifications:



External Ids:

Disease Ontology8 DOID:1558
ICD9CM27 995.1
MeSH34 D000799
ICD1025 T78.3

Related Diseases for Angioedema

About this section

Diseases in the Hereditary Angioedema Type Iii family:

Hereditary Angioedema angioedema
Acquired Angioedema Angioedema, Hereditary, Types I and Ii
Acquired Angioedema Type 1 Acquired Angioedema Type 2

Diseases related to Angioedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary angioedema31.1KNG1, SERPING1, F12, BDKRB2, C1S
2c1 inhibitor deficiency31.0SERPING1, F12, KNG1
3urticaria30.2KNG1, C1S, F12, SERPING1, ACE, XPNPEP2
4pancreatitis30.0KNG1, C1S
5ischemia29.6BDKRB2, C1S, KNG1
6acquired angioedema10.8
7hereditary angioedema type iii10.6
8eosinophilia10.5
9vibratory angioedema10.5
10angioedema induced by ace inhibitors10.5
11laryngitis10.4
12angioedema, hereditary, types i and ii10.3
13lupus erythematosus10.3
14capillary leak syndrome10.2C1S, SERPING1
15herpes gestationis10.2
16systemic lupus erythematosus10.2
17endotheliitis10.2
18lymphedema10.2
19ludwig's angina10.2
20angiodysplasia10.2
21hereditary coproporphyria10.2
22lymphangitis10.2
23hereditary lymphedema10.2
24spondylarthropathy10.2
25cerebrovascular disease10.2ACE, F12
26arthritis10.1
27hypertension10.1
28acute pancreatitis10.1
29dermatitis10.1
30carcinoid syndrome10.1
31hypocomplementemic urticarial vasculitis syndrome10.1
32blindness10.1
33acquired angioedema type 210.1
34renal hypertension10.1ACE, KNG1
35acute kidney failure10.1C1S, KNG1
36atherosclerosis10.0
37celiac disease10.0
38chronic lymphocytic leukemia10.0
39crohn's disease10.0
40hemolytic anemia10.0
41hepatitis10.0
42hodgkin's lymphoma10.0
43leukemia10.0
44myelofibrosis10.0
45non-hodgkin lymphoma10.0
46adult-onset still's disease10.0
47blepharochalasis10.0
48autoimmune hemolytic anemia10.0
49loiasis10.0
50psoriatic arthritis10.0

Graphical network of the top 20 diseases related to Angioedema:



Diseases related to angioedema

Symptoms for Angioedema

About this section

Drugs & Therapeutics for Angioedema

About this section

Drug clinical trials:

Search ClinicalTrials for Angioedema

Search NIH Clinical Center for Angioedema

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Angioedema

About this section

Anatomical Context for Angioedema

About this section

MalaCards organs/tissues related to Angioedema:

32
Skin, Tongue, Testes, Endothelial, Heart, B cells, Small intestine, Colon, Thyroid, Eye, Brain, Liver, Lung, Breast, Myeloid, Monocytes

Animal Models for Angioedema or affiliated genes

About this section

Publications for Angioedema

About this section

Articles related to Angioedema:

(show top 50)    (show all 1067)
idTitleAuthorsYear
1
Hereditary angioedema: Molecular and clinical differences among European populations. (25258140)
2014
2
Prognostic factors in outcome of angioedema in the emergency department. (25295803)
2014
3
Anaphylaxis/angioedema caused by honey ingestion. (24433600)
2014
4
Recombinant human C1-esterase inhibitor relieves symptoms of hereditary angioedema attacks: phase 3, randomized, placebo-controlled trial. (24468257)
2014
5
Depression and anxiety in patients with hereditary angioedema. (24428960)
2013
6
The development of angioedema in a patient with type 2 diabetes due to a novel dipeptidyl peptidase-IV inhibitor, anagliptin. (23972359)
2013
7
Hereditary angioedema: epidemiology, management, and role of icatibant. (23662043)
2013
8
Onset of Orolingual Angioedema After Treatment of Acute Brain Ischemia with Alteplase Depends on the Site of Brain Ischemia: A Meta-analysis. (24350070)
2013
9
Diagnosing angioedema. (24176210)
2013
10
The burden of illness in patients with hereditary angioedema. (24125136)
2013
11
Recent advances in hereditary angioedema self-administration treatment: summary of an International Hereditary Angioedema Expert Meeting. (23689237)
2013
12
Practical algorithm for diagnosing patients with recurrent wheals or angioedema. (23646863)
2013
13
The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency. (23318225)
2013
14
Management of hereditary angioedema in 2012: scientific and pharmacoeconomic perspectives. (23352523)
2013
15
Hereditary angioedema: not an allergy. (23248378)
2012
16
Prospective, double-blind, placebo-controlled trials of ecallantide for acute attacks of hereditary angioedema. (22149337)
2012
17
Hereditary angioedema: short-term prophylaxis for surgery. (22856630)
2012
18
Efficacy assessments in randomized controlled studies of acute therapy for hereditary angioedema. (22797816)
2012
19
Type III hereditary angioedema: defined, but not understood. (22920066)
2012
20
Successful C1 esterase inhibitor therapy in a child with a novel type 3 hereditary angioedema-like syndrome. (22626603)
2012
21
Hereditary angioedema: a survey of UK emergency departments and recommendations for management. (22008588)
2012
22
Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema. (22994404)
2012
23
Isolated angioedema of the bowel due to C1 esterase inhibitor deficiency: a case report and review of literature. (21320328)
2011
24
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
25
Hereditary angioedema: an instructive model of clinical description, molecular discovery, and development of new effective treatments. (22195754)
2011
26
In brief: icatibant (Firazyr) for hereditary angioedema. (22113125)
2011
27
Hereditary angioedema therapy: kallikrein inhibition and bradykinin receptor antagonism. (23282868)
2010
28
Summary and Conclusions: New Perspectives in Hereditary Angioedema: Molecular Mechanisms and Therapeutic Choices: A CME Symposium Presented at the World Allergy Congress, Buenos Aires, Argentina (December 2009). (23282869)
2010
29
Response time for ecallantide treatment of acute hereditary angioedema attacks. (21130380)
2010
30
Pathogenesis and laboratory diagnosis of hereditary angioedema. (19843402)
2009
31
Icatibant for hereditary angioedema. (20135020)
2009
32
Acute edema blisters in a hereditary angioedema cutaneous attack. (18680708)
2008
33
Orolingual angioedema as complication after rt-PA in stroke patient treated with ACE inhibitor]. (18453163)
2008
34
Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients. (18320917)
2008
35
Treatment of hereditary angioedema with plasma-derived C1 inhibitor. (19209279)
2008
36
Hereditary angioedema: new hopes for an orphan disease. (19160940)
2008
37
Not all ACE inhibitor related angioedema is always evident: a case which is misdiagnosed as panic attack and speech disorder. (18047821)
2007
38
Hereditary angioedema associated with heterozygous factor V Leiden mutation in a patient with Purpura fulminans. (17068406)
2007
39
Haploinsufficiency due to deletion within the 3'-UTR of C1-INH-gene associated with hereditary angioedema. (16617246)
2006
40
Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema. (15053206)
2004
41
Angioedema associated with angiotensin-converting enzyme inhibitor use: outcome after switching to a different treatment. (15111379)
2004
42
Clinical and biological distinctions between type I and type II acquired angioedema. (14553889)
2003
43
Rapid detection by fluorescent multiplex PCR of exon deletions and duplications in the C1 inhibitor gene of hereditary angioedema patients. (11139243)
2001
44
Angioedema due to losartan. (10492494)
1999
45
Angioedema due to ACE inhibitors: increased risk in patients of African origin. (10594491)
1999
46
ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema. (9793599)
1998
47
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
48
Hereditary angioedema. Description of a pediatric case]. (1791801)
1991
49
Angioedema from angiotensin converting enzyme inhibitors: a cause of upper airway obstruction. (2233075)
1990
50
Allergic urticaria and hereditary angioedema. Independent association in the same patient. (6509770)
1984

Variations for Angioedema

About this section

Expression for genes affiliated with Angioedema

About this section
Expression patterns in normal tissues for genes affiliated with Angioedema

Search GEO for disease gene expression data for Angioedema.

Pathways for genes affiliated with Angioedema

About this section

Pathways related to Angioedema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7SERPING1, F12
29.7SERPING1, C1S
3
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.7SERPING1, C1S
4
Show member pathways
9.6ACE, CPN1
5
Show member pathways
9.5KNG1, SERPING1
6
Show member pathways
9.1F12, SERPING1, KNG1
7
Show member pathways
9.1SERPING1, KNG1, F12
8
Show member pathways
8.5ACE, BDKRB2, KNG1
9
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
7.8C1S, F12, BDKRB2, KNG1, SERPING1

Compounds for genes affiliated with Angioedema

About this section

Compounds related to Angioedema according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1zofenoprilat449.8ACE, KNG1
2enalaprilate449.8KNG1, ACE
3imidaprilat449.7KNG1, ACE
4capoten449.7ACE, KNG1
5moexiprilat449.7ACE, KNG1
6delapril449.7ACE, KNG1
7fosinoprilat449.7ACE, KNG1
8perindoprilat449.7KNG1, ACE
9lacidipine449.7KNG1, ACE
10imidapril44 5010.7KNG1, ACE
11saralasin449.7ACE, KNG1
12an 69449.7ACE, KNG1
13eprosartan44 28 1111.6ACE, KNG1
14cilazapril44 1110.6KNG1, ACE
15omapatrilat449.6ACE, KNG1
16trandolapril44 1110.6ACE, KNG1
17isosorbide dinitrate44 50 1111.6KNG1, ACE
18quinapril44 50 1111.6ACE, KNG1
19cereport449.5BDKRB2, KNG1
20fr17365744 2810.4KNG1, BDKRB2
21ramipril44 1110.4ACE, KNG1
22fr19099744 2810.4KNG1, BDKRB2
23win 64338 hydrochloride619.4BDKRB2, KNG1
24hoe 140619.4BDKRB2, KNG1
25r 715619.4KNG1, BDKRB2
26lys-[des-arg9]bradykinin619.4BDKRB2, KNG1
27thiorphan44 28 1111.4KNG1, ACE
28des-arg(10)-kallidin449.4BDKRB2, KNG1
29mepyramine44 1110.2KNG1, BDKRB2
30prostacyclin449.1KNG1, C1S, ACE
31perindopril44 50 1111.0KNG1, ACE
32n(g)-nitro-l-arginine methyl ester449.0KNG1, BDKRB2
33quinaprilat449.0ACE, KNG1, BDKRB2
34heparin44 28 24 1112.0KNG1, C1S, F12, SERPING1
35ramiprilat449.0BDKRB2, ACE, KNG1
36icatibant44 28 1111.0BDKRB2, KNG1, ACE
37kallidin44 289.9ACE, KNG1, BDKRB2
38enalaprilat448.9BDKRB2, ACE, KNG1
39lisinopril44 50 24 1111.9KNG1, BDKRB2, ACE
40candesartan44 50 28 1111.9BDKRB2, KNG1, ACE
41aprotinin44 119.9BDKRB2, KNG1, C1S
42captopril44 61 50 28 1112.9BDKRB2, KNG1, ACE
43aspirin44 50 28 2411.9C1S, F12, ACE, KNG1
44losartan44 50 28 1111.9ACE, BDKRB2, KNG1
45nifedipine44 28 50 1111.8ACE, KNG1, BDKRB2
46bradykinin61 28 2410.6F12, ACE, KNG1, BDKRB2
47arginine448.2BDKRB2, C1S, CPN1, KNG1
48kininogen448.1BDKRB2, KNG1, ACE, C1S, F12
49serine448.0BDKRB2, KNG1, F12, C1S, SERPING1
50nitric oxide44 24 1110.0KNG1, ACE, C1S, BDKRB2

GO Terms for genes affiliated with Angioedema

About this section

Cellular components related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4SERPING1, KNG1
2blood microparticleGO:0725629.2C1S, SERPING1, KNG1
3extracellular spaceGO:0056158.8ACE, CPN1, SERPING1, F12
4extracellular regionGO:0055768.2KNG1, C1S, ACE, SERPING1, F12
5extracellular vesicular exosomeGO:0700628.2KNG1, XPNPEP2, ACE, SERPING1
6plasma membraneGO:0058867.6F12, ACE, KNG1, BDKRB2, XPNPEP2

Biological processes related to Angioedema according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.8SERPING1, F12
2complement activation, classical pathwayGO:0069589.6C1S, SERPING1
3platelet degranulationGO:0025769.5SERPING1, KNG1
4arachidonic acid secretionGO:0504829.3BDKRB2, ACE
5blood coagulation, intrinsic pathwayGO:0075979.3F12, SERPING1, KNG1
6blood circulationGO:0080159.3BDKRB2, SERPING1
7regulation of vasoconstrictionGO:0192299.3BDKRB2, ACE
8vasodilationGO:0423119.2KNG1, BDKRB2
9smooth muscle contractionGO:0069399.1BDKRB2, KNG1
10blood coagulationGO:0075968.8F12, SERPING1, KNG1

Molecular functions related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:0082379.1XPNPEP2, ACE
2protein bindingGO:0055157.3BDKRB2, KNG1, ACE, SERPING1, F12, C1S

Products for genes affiliated with Angioedema

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Angioedema

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet