MCID: ANG015
MIFTS: 54

Angioedema malady

Summaries for Angioedema

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63Wikipedia, 32MalaCards
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Wikipedia:63 Angioedema (BE: angiooedema) or Quincke\'s edema is the rapid swelling (edema) of the dermis,... more...

MalaCards: Angioedema, also known as angioneurotic oedema, is related to hereditary angioedema and urticaria. An important gene associated with Angioedema is SERPING1 (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1), and among its related pathways are Common Pathway and Platelet degranulation . The drug fluoxymesterone and the compounds moexiprilat and enalaprilate have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and endothelial, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Angioedema

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

angioedema 8 10 44 60
angioneurotic oedema 8
angioneurotic edema 8
quincke's edema 8
giant urticaria 8


External Ids:

Disease Ontology8 DOID:1558
MeSH34 D000799
ICD1025 T78.3

Related Diseases for Angioedema

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17GeneCards, 18GeneDecks
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Diseases in the Angioedema family:

Acquired Angioedema Acquired Angioedema Type 1
Acquired Angioedema Type 2

Diseases related to Angioedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary angioedema31.8SERPING1, F12, KNG1, C4B, BDKRB2, C1S
2urticaria31.1KNG1, XPNPEP2, HNMT, C1S, C1R, F12
3c1 inhibitor deficiency31.0KNG1, F12, KRTAP10-9, SERPING1
4lupus erythematosus30.3C1R, C1S, F5
5stroke, ischemic30.3F5
6complement deficiency30.1C1S, C1R
7acute pancreatitis30.1PRSS2, C1S
8hypertension30.1ACE, KNG1, F5, KLK1
9arthritis30.1KNG1
10vasculitis29.9C1S
11atherosclerosis29.9ACE, AGTR2, KNG1
12ischemia29.9C1S, BDKRB2, KNG1, AGTR2
13glomerulonephritis29.7KNG1
14pneumonia29.7KNG1
15eosinophilia10.5
16laryngitis10.4
17angioedema induced by ace inhibitors10.4
18angioedema, hereditary, types i and ii10.3
19hereditary angioedema type iii10.3
20vibratory angioedema10.2
21acquired angioedema10.2
22herpes gestationis10.2
23systemic lupus erythematosus10.1
24hereditary lymphedema10.1
25lymphangitis10.1
26angiodysplasia10.1
27hereditary coproporphyria10.1
28ludwig's angina10.1
29lymphedema10.1
30allergic urticaria10.1
31dermatitis10.1
32pancreatitis10.1
33thyroiditis10.1
34sinusitis10.0LTC4S
35rhinitis10.0KNG1
36acute myocardial infarction10.0SERPING1, ACE
37retinal vein occlusion10.0F5
38cerebrovascular disease10.0ACE, F12
39factor xii deficiency10.0F5, F12
40primary hyperoxaluria10.0KNG1
41ovarian hyperstimulation syndrome10.0F5
42allergic rhinitis10.0KNG1, HNMT
43coronary heart disease10.0ACE
44vesicoureteral reflux10.0AGTR2
45thromboembolism10.0F5, F12
46purpura fulminans10.0F5
47renal hypertension10.0KNG1, ACE
48thrombophilia10.0F12, F5
49essential hypertension10.0BDKRB2, KNG1, AGTR2, ACE
50ischemic heart disease10.0C1S, KNG1, AGTR2, ACE

Graphical network of the top 20 diseases related to Angioedema:



Diseases related to angioedema

Clinical Features for Angioedema

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Drugs & Therapeutics for Angioedema

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angioedema

Drug clinical trials:

Search ClinicalTrials for Angioedema

Search NIH Clinical Center for Angioedema

Search CenterWatch for Angioedema

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Angioedema

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Anatomical Context for Angioedema

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32MalaCards
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MalaCards organs/tissues related to Angioedema:

32
Tongue, Testes, Endothelial, Thyroid, Heart, Small intestine, Colon, Skin, B cells, Myeloid, Breast, Liver, Brain, Lung, Eye

Animal Models for Angioedema or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angioedema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.0SERPING1, ACE, SLC4A3, LTC4S, AGTR2, F5

Publications for Angioedema

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50PubMed
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Articles related to Angioedema:

(show top 50)    (show all 1037)
idTitleAuthorsYear
1
The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency. (23318225)
2013
2
Hereditary angioedema: quality of life in Brazilian patients. (23420162)
2013
3
Acute dystonia mimicking angioedema of the tongue: a video-illustrated case. (23836783)
2013
4
C1 inhibitor concentrate treatment of multiple laryngeal attacks in a 53-year-old woman with hereditary angioedema. (23647478)
2013
5
Pediatric hereditary angioedema. (24313851)
2013
6
Fresh frozen plasma for progressive and refractory angiotensin-converting enzyme inhibitor-induced angioedema. (23114109)
2013
7
Creating a comprehensive treatment plan for hereditary angioedema. (24176212)
2013
8
Update on preventive therapy (prophylaxis) for hereditary angioedema. (24176214)
2013
9
Hereditary Angioedema - Consequences of a New Treatment Paradigm in Denmark. (24202369)
2013
10
Update on treatment of hereditary angioedema. (23517035)
2013
11
Pathogenic intracellular and autoimmune mechanisms in urticaria and angioedema. (22674016)
2013
12
Intubation of patients with angioedema: A retrospective study of different methods over three year period. (23961454)
2013
13
Acquired angioedema with raised serum tryptase. (23244664)
2013
14
Prospective, double-blind, placebo-controlled trials of ecallantide for acute attacks of hereditary angioedema. (22149337)
2012
15
Type III hereditary angioedema: defined, but not understood. (22920066)
2012
16
Angioedema in the emergency department: an evidence-based review. (23137438)
2012
17
Treatment of laryngeal hereditary angioedema. (21315535)
2012
18
Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency. (22841766)
2012
19
Nonhistaminergic idiopathic angioedema: clinical response to icatibant. (23397675)
2012
20
Clinical efficacy of icatibant in the treatment of acute hereditary angioedema during the FAST-3 trial. (23167682)
2012
21
Utility of routine laboratory testing in management of chronic urticaria/angioedema. (21875543)
2011
22
Meeting the challenges and burdens associated with hereditary angioedema. (21991862)
2011
23
Icatibant in hereditary angioedema: news and challenges. (21595592)
2011
24
Treatment of acquired angioedema with icatibant: a case report. (20680518)
2011
25
Hereditary angioedema: three cases report, members of the same family. (24421965)
2010
26
Safety of meloxicam in patients with aspirin/non-steroidal anti-inflammatory drug-induced urticaria and angioedema. (21039786)
2010
27
Hereditary angioedema in women. (20667120)
2010
28
Optimal medical management of acute attacks of acquired angioedema. (20042567)
2010
29
2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. (20667127)
2010
30
Cinryze, a human plasma-derived c1 esterase inhibitor for prophylaxis of hereditary angioedema. (19572047)
2009
31
Carcinoid syndrome with angioedema and urticaria. (18490608)
2008
32
Hereditary angioedema: a current state-of-the-art review, III: mechanisms of hereditary angioedema. (18220146)
2008
33
Hereditary angioedema: a current state-of-the-art review, V: attenuated androgens for the treatment of hereditary angioedema. (18220148)
2008
34
Angioedema due to acquired C1-inhibitor deficiency: a bridging condition between autoimmunity and lymphoproliferation. (19014872)
2008
35
Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. (18447143)
2008
36
Fresh frozen plasma for the treatment of hereditary angioedema. (17458436)
2007
37
Unilateral lacrimal gland atrophy in a patient with hereditary angioedema. (17457207)
2007
38
Early presentation with angioedema and urticaria in cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs among young, Asian, atopic children. (16230465)
2005
39
Correction of recurrent angioedema related to C1 esterase inhibitor deficiency as a secondary event following nonmyeloablative allogeneic stem cell transplantation in a patient with myelofibrosis. (15531899)
2005
40
Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema. (16136765)
2005
41
A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema. (16210064)
2005
42
Detection of C1 inhibitor (SERPING1/C1NH) mutations in exon 8 in patients with hereditary angioedema: evidence for 10 novel mutations. (12402344)
2002
43
Hereditary angioedema: report of a case. (11393912)
2001
44
Angioedema of the mucous membranes of the upper aerodigestive tract after administration of ACE inhibitors]. (9172718)
1997
45
Interferon alpha 2a therapy for urticarial vasculitis with angioedema apparently following hepatitis A infection. (8882052)
1996
46
Epidemiological study of angioedema and ACE inhibitors. (9028507)
1996
47
Isolated uvular angioedema associated with ACE inhibitor use. (7673623)
1995
48
Increased serum level of interleukin-5 in a patient with episodic angioedema and eosinophilia syndrome. (8358129)
1993
49
Angioedema and C1 inhibitor deficiency. (1524272)
1992
50
Episodic angioedema with eosinophilia (Gleich syndrome). (2148252)
1990

Genetic Variations for Angioedema

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Expression for genes affiliated with Angioedema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angioedema

Search GEO for disease gene expression data for Angioedema.

Pathways for genes affiliated with Angioedema

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53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 55SinoBiological, 37NCBI BioSystems Database, 49PharmGKB, 52R&D Systems
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Compounds for genes affiliated with Angioedema

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Angioedema according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1moexiprilat4410.8KNG1, ACE
2enalaprilate4410.7KNG1, ACE
3quinaprilat4410.7BDKRB2, KNG1, ACE
4capoten4410.7ACE, KNG1
5ramiprilat4410.7KNG1, BDKRB2, ACE
6zofenoprilat4410.7ACE, KNG1
7cereport4410.7BDKRB2, KNG1
8icatibant44 28 1112.7BDKRB2, KNG1, ACE
9imidaprilat4410.7KNG1, ACE
10fr17365744 2811.7BDKRB2, KNG1
11kallidin44 2811.7BDKRB2, ACE, KNG1
12fr19099744 2811.7BDKRB2, KNG1
13saralasin4410.7AGTR2, ACE, KNG1
14enalaprilat4410.7BDKRB2, KNG1, ACE
15captopril44 28 49 59 1114.7KNG1, AGTR2, BDKRB2
16lys-[des-arg9]bradykinin5910.7KNG1, BDKRB2
17lisinopril44 11 2412.7BDKRB2, KNG1, ACE
18win 64338 hydrochloride5910.7BDKRB2, KNG1
19delapril4410.7KNG1, ACE
20bradykinin59 28 2412.7BDKRB2, F12, KNG1, ACE
21r 7155910.7BDKRB2, KNG1
22hoe 1405910.7KNG1, BDKRB2
23aprotinin44 1111.7C1S, F5, KLK1, BDKRB2
24fosinoprilat4410.7ACE, KNG1
25candesartan44 28 1112.7ACE, AGTR2, KNG1, BDKRB2
26perindoprilat4410.7KNG1, ACE
27des-arg(10)-kallidin4410.7KNG1, BDKRB2
28enalapril44 49 1112.6KNG1, AGTR2, ACE
29losartan44 49 28 1113.6KNG1, AGTR2, ACE, BDKRB2
30imidapril4410.6ACE, KNG1
31serine4410.6BDKRB2, F12, SERPING1, KNG1, KLK1
32lacidipine4410.6KNG1, ACE
33prostacyclin4410.6F5, C1S, KNG1, AGTR2, ACE
34nafamostat mesilate4410.6KNG1, F5
35ang ii4410.6ACE, KNG1, AGTR2
36heparin44 28 11 2413.6SERPING1, KNG1, F12, C4B, C1S, F5
37angiotensin ii28 2411.5AGTR2, ACE
38an 694410.5ACE, KNG1
39kininogen4410.5F5, ACE, KNG1, F12, BDKRB2, KLK1
40kaolin4410.5F12, F5
41aspirin44 49 28 2413.5HNMT, F5, KNG1, F12, LTC4S, ACE
42eprosartan44 28 1112.5ACE, KNG1
43arginine4410.5C1S, KLK1, BDKRB2, F5, KNG1, AGTR2
44omapatrilat4410.4ACE, KNG1
45trandolapril44 1111.4KNG1, ACE
46nitric oxide44 11 2412.4AGTR2, C1S, ACE, KNG1, BDKRB2, F5
47anthranilate4410.4KLK1, KNG1
48pd12331944 2811.2AGTR2, ACE
49calcium44 49 11 2413.2F5, KNG1, AGTR2, LTC4S, C4B, PRSS2
50cilazapril44 1111.1KNG1, ACE

GO Terms for genes affiliated with Angioedema

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16Gene Ontology
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Cellular components related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3SERPING1, KNG1, F5
2extracellular spaceGO:0056159.7C4B, F5, KNG1, F12, PRSS2, ACE
3extracellular regionGO:0055769.7SERPING1, C1R, C1S, C4B, F5, KNG1

Biological processes related to Angioedema according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:00759710.6SERPING1, F12, KNG1
2blood circulationGO:00801510.5BDKRB2, F5, SERPING1
3complement activation, classical pathwayGO:00695810.5C1R, C1S, C4B, SERPING1
4complement activationGO:00695610.5C4B, C1S, C1R
5platelet degranulationGO:00257610.5SERPING1, KNG1, F5
6positive regulation of renal sodium excretionGO:03581510.4AGTR2, KNG1
7arachidonic acid secretionGO:05048210.4ACE, BDKRB2
8regulation of vasoconstrictionGO:01922910.4BDKRB2, ACE
9inflammatory responseGO:00695410.3BDKRB2, C4B, KNG1, AGTR2
10innate immune responseGO:04508710.3C1R, C1S, C4B, F12, PRSS2, SERPING1
11fibrinolysisGO:04273010.3SERPING1, F12
12proteolysisGO:00650810.3CPN1, C1R, C1S, KLK1, XPNPEP2, F12
13vasodilationGO:04231110.1BDKRB2, KNG1

Molecular functions related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.9PRSS2, F12, KLK1, C1S
2protein bindingGO:0055159.7C1S, BDKRB2, F5, KNG1, F12, PRSS2

Products for genes affiliated with Angioedema

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Sources for Angioedema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet