Angioedema malady

Wikipedia: Angioedema (BE: angiooedema) or Quincke\'s edema is the rapid swelling (edema) of the dermis,...⁴⁴ more...

MalaCards: Angioedema, also known as angioneurotic edema, is related to hereditary angioedema and acquired angioedema. An important gene associated with Angioedema is SERPING1 (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1), and among its related pathways are Complement cascade and Extrinsic Prothrombin Activation Pathway. The drug fluoxymesterone and the compounds kallidin and bradykinin have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and liver, and related mouse phenotypes are integument and renal/urinary system.

Aliases & Descriptions:

angioedema 6 7 8 32 43 angioneurotic edema 6 7 giant urticaria (disorder) 6 angioedema (disorder) 6

angioneurotic oedema 6 giant urticaria 6 quincke's edema 6

Diseases related to angioedema by text searches and GeneDecks gene sharing:

(show top 50)    (show all 450)

id	Related Disease	Score	Top Affiliating Genes
1	hereditary angioedema	37.4	SERPING1, BDKRB2, F12, CR1, C1S, C4B
2	acquired angioedema	32.9	SERPINC1, SERPING1, F5, C1S
3	c1 inhibitor deficiency	31.9	SERPINA4, SERPING1, MASP2, F12, KRTAP10-9, KLKB1
4	alpha 1-antitrypsin deficiency	30.5	SERPINC1, SERPINA1, SERPINB1, IGHE, C1S
5	crohn's disease	29.7	BDKRB2, IL6, ALOX5, PTGS2, PTGS1, C5AR1
6	purpura fulminans	28.1	SERPINC1, F5, PLAT, C1S
7	antithrombin iii deficiency	28.1	SERPINC1, F5, PLG
8	atherosclerosis	28.0	LCAT, CETP, ALOX5
9	food allergy	27.8	CETP, IL5, IGHE, RNASE3, C1S
10	antiphospholipid syndrome	27.6	SERPINC1, IGHE, F5, F12, PLAT, PON1
11	thromboembolism	27.3	SERPINC1, F5, F11, F12, PLAT, PLG
12	hepatitis	27.1	SERPINA1, CDH5, IFNA2, CR1, PON1
13	urticaria	26.9	SERPINC1, SERPINA4, SERPING1, SERPINB1, XPNPEP2, MS4A2
14	eosinophilia	26.9	SERPINA1, BDKRB2, MS4A2, CD69, IL2, IL5
15	autoimmune hemolytic anemia	25.8	SERPING1, IL2, IL5, IGHE, IFNA2, F5
16	systemic lupus erythematosus	25.7	SERPINB1, CD69, IL2, IL6, ALOX5, CR1
17	hemolytic anemia	25.6	SERPING1, LCAT, IL2, IL5, IGHE, IFNA2
18	hepatitis a	25.6	SERPINC1, IL2, APP, IGHE, IFNA2, F5
19	laryngitis	24.3	IL2, IL6, IFNA2, HRH2, PTGS2, PLAT
20	periodontitis	23.5	SERPINA1, CETP, MS4A2, IL2, IL5, IL6
21	anemia	23.1	SERPINC1, SERPING1, LCAT, MME, IL2, IL5
22	cervicitis	23.1	SERPINC1, SERPINA1, MME, IL2, IL5, IL6
23	purpura	22.9	SERPINC1, MME, IL2, IL5, IL6, IGHE
24	lupus erythematosus	22.7	SERPINC1, SERPING1, SERPINB1, MS4A2, CD69, CD93
25	vasculitis	22.6	SERPINC1, SERPINA1, SERPING1, SERPINB1, IL2, IL5
26	glomerulonephritis	22.0	SERPINC1, SERPING1, SERPINB1, LCAT, MME, IL2
27	cholesterol	21.9	SERPINC1, SERPINA1, SERPING1, BDKRB1, LCAT, CETP
28	melanoma	21.5	SERPINA1, CD69, CDH5, MME, IL2, IL5
29	non-hodgkin lymphoma	20.7	SERPING1, CD69, CD93, MME, IL2, IL5
30	hodgkin's lymphoma	20.6	SERPING1, CD69, CD93, MME, IL2, IL5
31	hypertension	19.5	SERPINC1, SERPINA4, SERPING1, BDKRB1, BDKRB2, LCAT
32	intermediate coronary syndrome	13.7	PLAT, PLG, ACE
33	aortic atherosclerosis	13.7	LCAT, CETP, F5, ACE
34	patent foramen ovale	13.7	SERPINC1, F5, F12, PLAT
35	venous tributary occlusion of retina	13.6	SERPINC1, F5, PLAT, KNG1
36	renal hypertension	13.6	KLKB1, ACE, KNG1
37	intracranial thrombosis	13.6	SERPINC1, F5, PLAT, PLG
38	dysfibrinogenemia	13.6	SERPINC1, F5, PLAT
39	central retinal artery occlusion	13.6	SERPINC1, F5, PLAT
40	helminthiasis	13.6	IL5, IGHE, RNASE3
41	pthirus pubis infestation	13.6	SERPINA1, IL5, IGHE
42	fibromuscular dysplasia	13.6	SERPINA1, ACE, AGT
43	erythrocytosis	13.6	F5, ACE, AGT, AGTR2
44	coronary restenosis	13.6	SERPINC1, CETP, PLAT, ACE
45	coronary thrombosis	13.6	SERPINC1, F5, PTGS2, PLAT
46	membranous glomerulonephritis	13.6	MME, F5, ACE, AGT
47	renovascular hypertension	13.6	SERPINC1, ACE, AGT, KNG1
48	intrinsic asthma	13.6	IL5, IGHE, RNASE3
49	arthus reaction	13.6	ALOX5, HRH1, CR1
50	cough variant asthma	13.6	IL5, IGHE, RNASE3, ACE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 fluoxymesterone

MalaCards organs/tissues related to angioedema:

²²

MGI Mouse Phenotypes related to angioedema:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	9.5	LTC4S, PTGS1, F5, APP, MME, CDH5
2	renal/urinary system phenotype	MP:0005367	9.4	AGTR2, AGT, C4B, PLG, PTGS1, FOXH1
3	respiratory system phenotype	MP:0005388	9.2	SLC4A3, LTC4S, CYSLTR1, F11, FOXH1, SERPINB1
4	adipose tissue phenotype	MP:0005375	8.8	PRCP, AGTR2, AGT, ACE, PTGS2, HRH1
5	hematopoietic system phenotype	MP:0005397	8.5	C5AR1, C4B, F11, IGHE, IL5, FOXH1
6	liver/biliary system phenotype	MP:0005370	8.4	AGT, PLG, HRH1, F11, IL6, IL2
7	digestive/alimentary phenotype	MP:0005381	7.7	PTGS1, PLAT, PLG, C4B, AGTR2, PTGS2
8	behavior/neurological phenotype	MP:0005386	6.8	PTGS2, PTGS1, PLAT, ACE, AGT, AGTR2
9	immune system phenotype	MP:0005387	6.4	F11, PTGS1, CYSLTR1, PLAT, PLG, LTC4S
10	cardiovascular system phenotype	MP:0005385	6.2	LTC4S, PLG, PLAT, CYSLTR1, PTGS1, KLKB1
11	homeostasis/metabolism phenotype	MP:0005376	5.6	C5AR1, HRH2, PTGS2, PTGS1, PLAT, PLG

Articles related to angioedema:

(show top 50)    (show all 280)

id	Title	Authors	Year	Affiliating Genes
1	Hereditary angioedema: key role for kallikrein and br adykinin in vascular endothelial-cadherin cleavage and edema formation. (21439626)	Bouillet L.... Vilgrain I.	2011	CDH5
2	A novel mutation in the coagulation factor 12 gene in subjects with hereditary angioedema and normal C1-inhibitor. (21849258)	Bork K.... Witzke G.	2011	F12
3	Peri-operative management of a patient with hereditar y angioedema undergoing laparoscopic cholecystectomy. (19849675)	Spyridonidou A.... Simopoulos C.	2010	C1S
4	Perioperative management of a patient with hereditary angioedema during off-pump coronary artery bypass graft surgery. (20522360)	Shick V.... Fleisher A.J.	2010	C1S
5	Angioedema during ACE and DPP-4 inhibition (20196430)	Waeber B.... Grouzmann E.	2010	ACE, KNG1
6	Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? (20163043)	Dobbels P.... Hiele M.	2009	ACE
7	Missense mutation Thr309Lys in the coagulation factor XII gene in a Spanish family with hereditary angioedema type III. (19178407)	Prieto A.... Rodriguez-Sainz C.	2009	F12
8	Kallikrein-kinin system and fibrinolysis in hereditar y angioedema due to factor XII gene mutation Thr309Lys. (19474702)	Bork K.... Witzke G.	2009	F12
9	Modern preoperative and intraoperative management of hereditary angioedema. (19368763)	Szema A.M.... Jen J.	2009	C1S
10	Clinical review of hereditary angioedema: diagnosis a nd management. (19940422)	Weis M.	2009	C1S
11	Angiotensin converting enzyme inhibitors and delayed onset, recurrent angioedema of the head and neck. (19023310)	Wakefield Y.S.... Pemberton M.N.	2008	ACE
12	Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. (18025295)	Byrd J.B.... Brown N.J.	2008	DPP4, KNG1
13	Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiency. (18204284)	SzAcplaki G.... Farkas H.	2008	SERPINC1
14	Endoscopic visualization of angiotensin-converting en zyme inhibitor-induced small bowel angioedema as a cause of relapsing abdominal pain using double-balloon enteroscopy. (18320317)	Spahn T.W.... Mueller M.K.	2008	ACE
15	Aliskiren as an alternative in a patient with life-th reatening ACE inhibitor-induced angioedema. (18295074)	Anzaldua D.A.... Schmitz P.G.	2008	ACE
16	New treatments addressing the pathophysiology of hereditary angioedema. (18410689)	Davis A.E.	2008	KNG1
17	Mutation screening of C1 inhibitor gene in 108 unrelated families with hereditary angioedema: functional and structural correlates. (18586324)	Pappalardo E.... Cicardi M.	2008	SERPING1
18	Depressed activation of the lectin pathway of complement in hereditary angioedema. (18460017)	Varga L.... Farkas H.	2008	MASP2, PRSS2
19	Hereditary angioedema: a current state-of-the-art review, III: mechanisms of hereditary angioedema. (18220146)	Davis A.E.	2008	KNG1
20	Treatment of hereditary angioedema: current perspectives. (19076006)	Krassilnikova S.I.... Craig T.J.	2008	KNG1
21	Not all ACE inhibitor related angioedema is always evident: a case which is misdiagnosed as panic attack and speech disorder. (18047821)	Gulec M.... Karaayvaz M.	2007	ACE
22	Anti-cholesterol antibody levels in hereditary angioedema. (18205707)	Varga L.... Farkas H.	2007	SERPING1
23	Tolerance to etoricoxib in 37 patients with urticaria and angioedema induced by nonsteroidal anti-inflammatory drugs. (17304885)	Muratore L.... Ferrannini A.	2007	PTGS2
24	Hereditary angioedema with normal C1 inhibitor: clinical symptoms and course. (17976427)	Bork K.... Dewald G.	2007	F12, SERPING1
25	Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant). (17418383)	Bork K.... Kreuz W.	2007	KNG1
26	Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor. (16638441)	Dewald G.... Bork K.	2006	F12
27	Skin venous thromboembolism by combined oral contrace ptive in a woman with acquired angioedema and Factor V Leiden mutation. (16472576)	OsmanaA9aoA9lu M.A.... Bozkaya H.	2006	F5
28	Hereditary angioedema with normal C1 inhibitor activity including hereditary angioedema with coagulation factor XII gene mutations. (17085286)	Bork K.	2006	F12
29	Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's Syndrome). (17085290)	Banerji A.... Sheikh J.	2006	IL2
30	Angioedema due to ACE inhibitors and AT(1) receptor antagonists (16240152)	Hellebrand M.C.... Bas M.	2006	ACE
31	Vascular endothelial growth factor is involved in angioedema associated with eosinophilia. (16422174)	Harada M.... Sata M.	2005	IL5
32	Hereditary angioedema. (16282771)	Frank M.M.	2005	KNG1
33	Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. (15356535)	AGOSTONI A.... Zingale L.	2004	C1S
34	Hereditary angioedema of delayed onset (14974896)	SA!nchez-Morillas L.... RodrA-guez Mosquera M.	2004	C1S
35	Identification of a novel mutation of C1 inhibitor gene in a Chinese family with hereditary angioedema (14714307)	Zhi Y.X.... Huang S.Z.	2003	SERPING1
36	Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke. (12743244)	Hill M.D.... Buchan A.M.	2003	PLAT, ACE
37	Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome). (14565669)	Morgan S.J.... Glaspole I.	2003	IL5
38	Recurrent attacks of angioedema ascribed to the use of estrogen preparations and a pregnancy (hereditary angioedema type 3) (12224485)	van der Klooster J.M.... Zweers P.G.	2002	C1S
39	Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema. (12222553)	Abdi R.... Ntoso K.A.	2002	ACE, KNG1
40	Angioedema in the emergency department: a presentation of lymphoma. (11903433)	Wellwood J.... Eliadis P.	2001	C1S
41	Angioedema associated with angiotensin II receptor antagonists: challenging our knowledge of angioedema and its etiology. (11801934)	Chiu A.G.... Deeb Z.E.	2001	ACE, AGTR2
42	C1-Esterase inhibitor: an anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema. (10699156)	Caliezi C.... Hack C.E.	2000	C1S
43	A 'de novo' arisen case of angioedema C1-inhibitor deficiency dependent: possible mutagenic effect of azathioprine? (10424251)	Guastafierro S.... Coppola L.	1999	SERPING1
44	Angioedema due to ACE inhibitors: increased risk in patients of African origin. (10594491)	Gibbs C.R.... Beevers D.G.	1999	ACE
45	A case of episodic angioedema associated with blood eosinophilia: upregulated C5a receptor expression on eosinophils. (9542615)	Nakashima K.... Abe M.	1998	C5AR1
46	Examination of baseline levels of carboxypeptidase N and complement components as potential predictors of angioedema associated with the use of an angiotensin-converting enzyme inhibitor. (9267242)	Sigler C.... Van deCarr S.	1997	C1S
47	Periodic angioedema with eosinophilia: increased serum level of interleukin 5. (7727874)	Okubo Y.... Sekiguchi M.	1995	IL5
48	Acquired C1 esterase inhibitor deficiency causing intestinal angioedema: CT appearance. (8249728)	Ciaccia D.... Baker M.E.	1993	C1S
49	Angioedema secondary to ACE inhibitors. (8251558)	Blaine D.E.... Frable M.A.	1993	ACE
50	Severe angioedema related to ACE inhibitors in patients with a history of idiopathic angioedema. (2167396)	Orfan N.... Dykewicz M.S.	1990	ACE

Genes related to angioedema according to GeneCards:

(show top 50)    (show all 60)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	11.1	Publications, Aliases & Descriptions
2	CPN1	carboxypeptidase N, polypeptide 1	11.1	Summaries
3	F12	coagulation factor XII (Hageman factor)	11.0	Publications
4	C1S	complement component 1, s subcomponent	11.0	Publications
5	XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	11.0	Publications
6	KNG1	kininogen 1	11.0	Publications
7	BDKRB2	bradykinin receptor B2	11.0	Publications
8	C4B	complement component 4B (Chido blood group)	11.0	Publications
9	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
10	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	11.0	Publications
11	PRSS2	protease, serine, 2 (trypsin 2)	11.0	Publications
12	PFDN4	prefoldin subunit 4	11.0
13	SLC4A3	solute carrier family 4, anion exchanger, member 3	11.0
14	LTC4S	leukotriene C4 synthase	11.0	Publications
15	KLK1	kallikrein 1	11.0	Publications
16	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
17	C1R	complement component 1, r subcomponent	11.0
18	HNMT	histamine N-methyltransferase	11.0	Publications
19	MASP2	mannan-binding lectin serine peptidase 2	11.0	Publications
20	AGTR2	angiotensin II receptor, type 2	11.0	Publications
21	CDH5	cadherin 5, type 2 (vascular endothelium)	11.0	Publications
22	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
23	PLAT	plasminogen activator, tissue	11.0	Publications
24	PLG	plasminogen	11.0	Publications
25	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
26	HRH1	histamine receptor H1	11.0	Publications
27	DPP4	dipeptidyl-peptidase 4	11.0	Publications
28	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
29	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
30	PON1	paraoxonase 1	11.0	Publications
31	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
32	MME	membrane metallo-endopeptidase	11.0	Publications
33	RNASE3	ribonuclease, RNase A family, 3	11.0
34	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
35	ALOX5	arachidonate 5-lipoxygenase	11.0	Publications
36	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0
37	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
38	APP	amyloid beta (A4) precursor protein	11.0	Publications
39	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
40	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0
41	KRTAP10-9	keratin associated protein 10-9	11.0	Disorders
42	FOXH1	forkhead box H1	11.0
43	SERPINA4	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	11.0
44	CD93	CD93 molecule	11.0	Publications
45	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0	Publications
46	KLKB1	kallikrein B, plasma (Fletcher factor) 1	11.0	Publications
47	BDKRB1	bradykinin receptor B1	11.0	Publications
48	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	11.0
49	PRCP	prolylcarboxypeptidase (angiotensinase C)	11.0
50	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	11.0	Publications

Pathways related to angioedema according to GeneDecks:

(show all 31)

id	Pathway	Score	Top Affiliating Genes
1	Complement cascade38	10.3	C1R, C1S, CR1, MASP2
2	Extrinsic Prothrombin Activation Pathway36	10.3	SERPINC1, F5, F12
3	Renin-angiotensin system20	10.3	AGTR2, AGT, ACE, MME
4	ACE Inhibitor Pathway, Pharmacodynamics34	10.3	AGTR2, MME, BDKRB2, BDKRB1
5	Complement Pathway36	10.3	MASP2, C1S, C1R
6	Cell adhesion_Plasmin signaling41	10.2	KLKB1, PLG, PLAT, F12, SERPING1
7	Cell adhesion Plasmin signaling10	10.2	KLKB1, PLG, PLAT, F12, SERPING1
8	HETE and HPETE biosynthesis and metabolism10	10.1	PTGS1, PTGS2, ALOX5
9	Staphylococcus aureus infection20	10.1	C5AR1, C4B, C1R, C1S, PLG, MASP2
10	Protein digestion and absorption20	10.0	PRCP, PRSS2, DPP4, MME, XPNPEP2
11	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.0	KNG1, AGTR2, AGT, ACE, MME, BDKRB2
12	G alpha (i) signalling events38	10.0	BDKRB1, BDKRB2, KNG1
13	Arachidonic acid metabolism20	10.0	LTC4S, PTGS1, PTGS2, ALOX5
14	Leukotriene modifiers pathway, Pharmacodynamics34	10.0	LTC4S, CYSLTR1, ALOX5AP, ALOX5
15	Intrinsic Pathway38	10.0	PRCP, F12, F11
16	Pertussis20	10.0	C4B, C1R, C1S, IL6, SERPING1
17	Immune response_Lectin induced complement pathway41	9.9	C5AR1, C4B, CR1, MASP2, CD93, SERPING1
18	Immune response Lectin Induced complement pathway10	9.9	C5AR1, C4B, CR1, MASP2, CD93, SERPING1
19	MSP-RON Signaling36	9.9	F11, F12, KLK1, KLKB1
20	Immune response Classic complement pathway10	9.8	C5AR1, C4B, C1R, C1S, CR1, CD93
21	Immune response_Classical complement pathway41	9.8	C5AR1, C4B, C1R, C1S, CR1, CD93
22	HETE and HPETE biosynthesis and metabolism41	9.8	PTGS2, ALOX5, PTGS1
23	Intrinsic Prothrombin Activation Pathway36	9.8	KLKB1, KLK1, F12, F11, F5, SERPINC1
24	Blood Coagulation Cascade36	9.8	KLKB1, KLK1, F12, F11, F5, SERPINC1
25	Blood Coagulation Signaling Pathways37	9.6	KNG1, KLKB1, PLG, PLAT, F12, F11
26	Metabolism of lipids and lipoproteins38	9.6	AGT, LTC4S, PTGS1, PTGS2, ALOX5AP, ALOX5
27	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	9.6	C5AR1, AGTR2, CYSLTR1, BDKRB2, BDKRB1
28	Neuroactive ligand-receptor interaction20	9.1	C5AR1, PRSS2, AGTR2, PLG, CYSLTR1, HRH2
29	all-trans-Retinoic Acid Signaling in Brain36	9.1	LTC4S, PTGS2, ALOX5, IL6, IL5, IL2
30	Cytokine Network36	8.9	IFNA2, IL6, IL5, IL2
31	Complement and coagulation cascades20	8.3	SERPINC1, C5AR1, KNG1, C4B, C1R, C1S

Compounds related to angioedema according to GeneDecks:

(show top 50)    (show all 282)

id	Compound	Score	Top Affiliating Genes
1	kallidin32	10.1	BDKRB1, BDKRB2, MME, KNG1, ACE
2	bradykinin42 18	11.1	ACE, BDKRB2, KLKB1, F12, BDKRB1, KNG1
3	enalaprilat32	10.0	BDKRB1, BDKRB2, MME, PLAT, ACE, AGT
4	captopril32 42 9 9	12.9	BDKRB2, KNG1, DPP4, BDKRB1, APP, PLG
5	isoproterenol32 9 9	11.8	APP, IGHE, IL5, HRH2, CDH5, HRH1
6	ltd432	9.8	CYSLTR1, LTC4S, HRH1, KNG1, ALOX5, RNASE3
7	diisopropylfluorophosphate32	9.8	SERPINC1, SERPINA1, LCAT, DPP4, PRCP, PON1
8	toluene diisocyanate32	9.7	IL5, IGHE, HNMT, RNASE3, MME
9	lte432	9.6	ALOX5, LTC4S, RNASE3, CYSLTR1, PTGS1, ALOX5AP
10	flurbiprofen32 34 9 9	12.6	COX5A, PTGS1, PTGS2, HRH1, APP, KNG1
11	zafirlukast32 9 9	11.5	ALOX5, ALOX5AP, PTGS1, CYSLTR1, RNASE3
12	montelukast32 34 9 9	12.4	LTC4S, IL5, IGHE, ALOX5, ALOX5AP, PTGS1
13	thromboxane32 18	10.4	COX5A, PLAT, KNG1, ALOX5AP, PTGS1, HRH1
14	zileuton32 42 9 9	12.4	LTC4S, COX5A, CYSLTR1, PTGS1, PTGS2, ALOX5AP
15	ascorbic acid32 18	10.3	MME, IFNA2, LCAT, IGHE, ALOX5, COX5A
16	ndga32	9.3	COX5A, PTGS1, PTGS2, HRH1, ALOX5AP, ALOX5
17	txb232	9.2	RNASE3, COX5A, PTGS1, PTGS2, C5AR1, ALOX5
18	epinephrine32 9 18 9	12.1	APP, F5, AGT, RNASE3, HRH2, HRH1
19	pgd232	9.0	IL5, ALOX5, PTGS2, PTGS1, CYSLTR1, RNASE3
20	ltc432	8.9	C5AR1, LTC4S, RNASE3, COX5A, CYSLTR1, PTGS1
21	prostacyclin32	8.8	PTGS2, F5, ALOX5, PTGS1, PLAT, COX5A
22	diclofenac32 34 9 9	11.8	COX5A, PTGS1, PTGS2, HRH2, ALOX5, IL5
23	thromboxane a232 18	9.8	BDKRB2, PLAT, AGT, ALOX5, PTGS2, PTGS1
24	adenylate32	8.7	IGHE, APP, IL5, MME, BDKRB2, HRH1
25	kininogen32	8.5	KLKB1, C1S, ACE, PRCP, KNG1, KLK1
26	cysteine32	8.4	COX5A, KLKB1, AGT, PRSS2, C5AR1, PLAT
27	vegf32	8.4	APP, C5AR1, PLG, AGT, RNASE3, COX5A
28	aprotinin32 9 9	10.3	IL6, IGHE, F5, F11, PLAT, PLG
29	pge232	8.3	BDKRB2, CD69, MME, IL5, ALOX5, ALOX5AP
30	leukotriene b432 42 18	10.1	RNASE3, LTC4S, KNG1, C5AR1, COX5A, CR1
31	fibrinogen32	8.0	F5, IL6, CDH5, SERPINA1, PON1, MASP2
32	arginine32	8.0	ALOX5, F5, AGTR2, IGHE, IL5, MME
33	prostaglandin32	8.0	BDKRB2, MME, IL6, ALOX5, ALOX5AP, HRH1
34	aspirin32 34 18	9.8	SERPINC1, CETP, APP, F5, PON1, KNG1
35	actinomycin d32	7.7	PTGS2, ALOX5AP, IGHE, APP, IL6, PLAT
36	cyclosporin a32 42	8.7	IL2, DPP4, AGT, RNASE3, AGTR2, CR1
37	genistein32 9 18 9	10.7	ALOX5, BDKRB2, CD69, CDH5, IL2, IL5
38	heparin32 9 18 9	10.5	SERPINA4, SERPINA1, SERPINB1, LCAT, CETP, CD69
39	estrogen32	7.3	ALOX5, F12, IFNA2, IL6, IGHE, SERPINC1
40	arachidonic acid32 9 18 9	10.3	ALOX5AP, HRH1, PTGS2, PTGS1, CYSLTR1, CR1
41	creatinine32	7.2	SERPINC1, SERPINA1, BDKRB2, CD69, MME, IL6
42	cycloheximide32	7.1	C5AR1, KNG1, DPP4, AGTR2, PLAT, CR1
43	alanine32	7.0	HRH1, C5AR1, DPP4, CETP, IL6, APP
44	calcium32 9 18 9	9.8	HRH2, HRH1, ALOX5AP, ALOX5, F5, MME
45	indomethacin32 9 9	8.8	PTGS1, CYSLTR1, PLAT, COX5A, AGT, AGTR2
46	nitric oxide32 9 18 9	9.4	C1S, BDKRB2, BDKRB1, SERPINA1, SERPINA4, CD69
47	dexamethasone32 42 34 9 9	10.4	PTGS2, PTGS1, CYSLTR1, COX5A, RNASE3, LTC4S
48	histamine32 18	7.2	BDKRB2, COX5A, RNASE3, LTC4S, KNG1, C5AR1
49	lipid32	6.1	CETP, HRH2, CYSLTR1, PLG, COX5A, LCAT
50	serine32	4.0	KLKB1, MASP2, SERPINC1, SERPINA4, SERPINA1, SERPING1

Cellular components related to angioedema according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle	GO:034364	10.1	LCAT, CETP, PON1
2	platelet alpha granule lumen	GO:031093	9.9	KNG1, PLG, F5, APP, SERPING1, SERPINA1
3	integral to plasma membrane	GO:005887	6.7	HRH2, CYSLTR1, CR1, AGTR2, SLC4A3, C5AR1
4	extracellular space	GO:005615	6.2	KNG1, IL6, IL5, IL2, CETP, LCAT
5	plasma membrane	GO:005886	6.2	CYSLTR1, CR1, PLG, KLKB1, C4B, ACE
6	extracellular region	GO:005576	5.9	KNG1, WFIKKN2, PON1, SERPINC1, IFNA2, MASP2

Biological processes related to angioedema according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	complement activation	GO:006956	10.3	C4B, C1R, C1S, MASP2
2	regulation of vasoconstriction	GO:019229	10.2	BDKRB2, ACE, AGT
3	fibrinolysis	GO:042730	10.2	SERPING1, F12, PLAT, PLG, KLKB1
4	cyclooxygenase pathway	GO:019371	10.2	PTGS2, PTGS1
5	complement activation, classical pathway	GO:006958	10.2	C4B, C1R, C1S, CR1, MASP2, SERPING1
6	platelet degranulation	GO:002576	10.2	KNG1, PLG, F5, APP, SERPING1, SERPINA1
7	regulation of renal output by angiotensin	GO:002019	10.1	ACE, AGT
8	regulation of blood pressure	GO:008217	10.1	AGTR2, ACE, PTGS1, PTGS2
9	positive regulation of vasoconstriction	GO:045907	9.9	CYSLTR1, PTGS1, PTGS2, HRH1, ALOX5
10	positive regulation of fibrinolysis	GO:051919	9.9	KLKB1, PLG, F12, F11
11	Factor XII activation	GO:002542	9.9	F12, KLKB1
12	plasminogen activation	GO:031639	9.9	F11, PLAT, KLKB1
13	response to glucocorticoid stimulus	GO:051384	9.7	CPN1, PLAT, PTGS2, HNMT, IL6, LCAT
14	blood coagulation, intrinsic pathway	GO:007597	9.7	KNG1, PRCP, KLKB1, F12, F11, SERPING1
15	platelet activation	GO:030168	9.6	KNG1, PLG, F5, APP, IL6, SERPING1
16	innate immune response	GO:045087	9.4	PRSS2, C4B, C1R, C1S, CR1, F12
17	positive regulation of immunoglobulin secretion	GO:051024	9.3	IL2, IL5, IL6
18	elevation of cytosolic calcium ion concentration	GO:007204	9.0	C5AR1, KNG1, CYSLTR1, IL2, BDKRB2, BDKRB1
19	proteolysis	GO:006508	8.8	XPNPEP2, CPN1, PRCP, PRSS2, DPP4, ACE
20	blood coagulation	GO:007596	8.4	KNG1, PRCP, KLKB1, PLG, PLAT, F12
21	inflammatory response	GO:006954	8.3	KNG1, AGTR2, C4B, CYSLTR1, PTGS2, HRH1

Molecular functions related to angioedema according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	bradykinin receptor activity	GO:004947	10.2	BDKRB1, BDKRB2
2	prostaglandin-endoperoxide synthase activity	GO:004666	9.9	PTGS2, PTGS1
3	protease binding	GO:002020	9.9	DPP4, BDKRB2, SERPINA1, SERPINC1
4	serine-type endopeptidase inhibitor activity	GO:004867	9.7	WFIKKN2, APP, SERPINB1, SERPING1, SERPINA1, SERPINC1
5	serine-type endopeptidase activity	GO:004252	9.2	MASP2, PRSS2, DPP4, C1S, KLKB1, KLK1
6	protein binding	GO:005515	6.2	ALOX5AP, F11, F12, PLAT, PLG, PFDN4