MCID: ANG015
MIFTS: 51

Angioedema malady

Genetic diseases, Bone diseases, Immune diseases, Rare diseases categories

Aliases & Classifications for Angioedema

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 25ICD10
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Angioedema, Aliases & Descriptions:

Name: Angioedema 9 11 43 60
Angioneurotic Oedema 9
Angioneurotic Edema 9
 
Giant Urticaria 9
Quincke's Edema 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases, Immune diseases


External Ids:

Disease Ontology9 DOID:1558
ICD9CM27 995.1
MeSH33 D000799
ICD1025 T78.3

Summaries for Angioedema

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Disease Ontology:9 A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues.

MalaCards based summary: Angioedema, also known as angioneurotic oedema, is related to c1 inhibitor deficiency and angioedema, hereditary, types i and ii. An important gene associated with Angioedema is SERPING1 (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1), and among its related pathways are Cell adhesion Plasmin signaling and Complement Pathway. The drug fluoxymesterone and the compounds imidaprilat and enalaprilate have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and testes.

Wikipedia:63 Angioedema (BE: angiooedema) or Quincke\'s edema is the rapid swelling (edema) of the dermis,... more...

Related Diseases for Angioedema

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Diseases in the Angioedema family:

Angioedema, Hereditary, Type Iii Angioedema, Hereditary, Types I and Ii
Acquired Angioedema Acquired Angioedema Type 1
Acquired Angioedema Type 2

Diseases related to Angioedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1c1 inhibitor deficiency31.0F12, SERPING1, KNG1
2angioedema, hereditary, types i and ii30.3C1S, F12, SERPING1, KNG1, BDKRB2
3urticaria30.2C1S, F12, SERPING1, ACE, XPNPEP2, KNG1
4pancreatitis30.0KNG1, C1S
5ischemia29.6C1S, KNG1, BDKRB2
6acquired angioedema10.9
7eosinophilia10.5
8vibratory angioedema10.5
9angioedema, hereditary, type iii10.4
10laryngitis10.4
11angioedema induced by ace inhibitors10.4
12lupus erythematosus10.3
13systemic lupus erythematosus10.2
14capillary leak syndrome10.2C1S, SERPING1
15herpes gestationis10.2
16endotheliitis10.2
17renin-angiotensin-aldosterone system-blocker-induced angioedema10.2
18acquired angioedema type 210.2
19coproporphyria10.2
20lymphedema10.2
21angiodysplasia10.2
22lymphangitis10.2
23ludwig's angina10.2
24hereditary lymphedema10.2
25spondylarthropathy10.2
26cerebrovascular disease10.1F12, ACE
27arthritis10.1
28acute pancreatitis10.1
29dermatitis10.1
30thyroiditis10.1
31carcinoid syndrome10.1
32hypocomplementemic urticarial vasculitis syndrome10.1
33macroglossia10.1
34blindness10.1
35acquired angioedema type 110.1
36renal hypertension10.1ACE, KNG1
37acute kidney failure10.1KNG1, C1S
38celiac disease10.0
39psoriatic arthritis10.0
40hodgkin lymphoma10.0
41atherosclerosis10.0
42chronic lymphocytic leukemia10.0
43crohn's disease10.0
44hemolytic anemia10.0
45hepatitis10.0
46leukemia10.0
47myelofibrosis10.0
48blepharochalasis10.0
49allergic urticaria10.0
50autoimmune hemolytic anemia10.0

Graphical network of the top 20 diseases related to Angioedema:



Diseases related to angioedema

Symptoms for Angioedema

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Drugs & Therapeutics for Angioedema

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Drug clinical trials:

Search ClinicalTrials for Angioedema

Search NIH Clinical Center for Angioedema

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Angioedema

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Anatomical Context for Angioedema

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MalaCards organs/tissues related to Angioedema:

31
Skin, Tongue, Testes, B cells, Endothelial, Heart, Thyroid, Small intestine, Colon, Eye, Brain, Liver, Lung, Breast, Myeloid, Monocytes

Animal Models for Angioedema or affiliated genes

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Publications for Angioedema

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Articles related to Angioedema:

(show top 50)    (show all 1109)
idTitleAuthorsYear
1
Lingual angioedema after alteplase treatment in a patient with acute ischemic stroke. (25802571)
2015
2
Hereditary angioedema: Molecular and clinical differences among European populations. (25258140)
2014
3
Prognostic factors in outcome of angioedema in the emergency department. (25295803)
2014
4
Anaphylaxis/angioedema caused by honey ingestion. (24433600)
2014
5
Recombinant human C1-esterase inhibitor relieves symptoms of hereditary angioedema attacks: phase 3, randomized, placebo-controlled trial. (24468257)
2014
6
Depression and anxiety in patients with hereditary angioedema. (24428960)
2013
7
The development of angioedema in a patient with type 2 diabetes due to a novel dipeptidyl peptidase-IV inhibitor, anagliptin. (23972359)
2013
8
Hereditary angioedema: epidemiology, management, and role of icatibant. (23662043)
2013
9
Onset of Orolingual Angioedema After Treatment of Acute Brain Ischemia with Alteplase Depends on the Site of Brain Ischemia: A Meta-analysis. (24350070)
2013
10
Diagnosing angioedema. (24176210)
2013
11
The burden of illness in patients with hereditary angioedema. (24125136)
2013
12
Recent advances in hereditary angioedema self-administration treatment: summary of an International Hereditary Angioedema Expert Meeting. (23689237)
2013
13
Practical algorithm for diagnosing patients with recurrent wheals or angioedema. (23646863)
2013
14
The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency. (23318225)
2013
15
Management of hereditary angioedema in 2012: scientific and pharmacoeconomic perspectives. (23352523)
2013
16
Hereditary angioedema: not an allergy. (23248378)
2012
17
Prospective, double-blind, placebo-controlled trials of ecallantide for acute attacks of hereditary angioedema. (22149337)
2012
18
Hereditary angioedema: short-term prophylaxis for surgery. (22856630)
2012
19
Efficacy assessments in randomized controlled studies of acute therapy for hereditary angioedema. (22797816)
2012
20
Successful C1 esterase inhibitor therapy in a child with a novel type 3 hereditary angioedema-like syndrome. (22626603)
2012
21
Hereditary angioedema: a survey of UK emergency departments and recommendations for management. (22008588)
2012
22
Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema. (22994404)
2012
23
Isolated angioedema of the bowel due to C1 esterase inhibitor deficiency: a case report and review of literature. (21320328)
2011
24
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
25
Hereditary angioedema: an instructive model of clinical description, molecular discovery, and development of new effective treatments. (22195754)
2011
26
In brief: icatibant (Firazyr) for hereditary angioedema. (22113125)
2011
27
Hereditary angioedema therapy: kallikrein inhibition and bradykinin receptor antagonism. (23282868)
2010
28
Summary and Conclusions: New Perspectives in Hereditary Angioedema: Molecular Mechanisms and Therapeutic Choices: A CME Symposium Presented at the World Allergy Congress, Buenos Aires, Argentina (December 2009). (23282869)
2010
29
Response time for ecallantide treatment of acute hereditary angioedema attacks. (21130380)
2010
30
Pathogenesis and laboratory diagnosis of hereditary angioedema. (19843402)
2009
31
Icatibant for hereditary angioedema. (20135020)
2009
32
Acute edema blisters in a hereditary angioedema cutaneous attack. (18680708)
2008
33
Orolingual angioedema as complication after rt-PA in stroke patient treated with ACE inhibitor]. (18453163)
2008
34
Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients. (18320917)
2008
35
Treatment of hereditary angioedema with plasma-derived C1 inhibitor. (19209279)
2008
36
Hereditary angioedema: new hopes for an orphan disease. (19160940)
2008
37
Not all ACE inhibitor related angioedema is always evident: a case which is misdiagnosed as panic attack and speech disorder. (18047821)
2007
38
Hereditary angioedema associated with heterozygous factor V Leiden mutation in a patient with Purpura fulminans. (17068406)
2007
39
Haploinsufficiency due to deletion within the 3'-UTR of C1-INH-gene associated with hereditary angioedema. (16617246)
2006
40
Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema. (15053206)
2004
41
Angioedema associated with angiotensin-converting enzyme inhibitor use: outcome after switching to a different treatment. (15111379)
2004
42
Clinical and biological distinctions between type I and type II acquired angioedema. (14553889)
2003
43
Rapid detection by fluorescent multiplex PCR of exon deletions and duplications in the C1 inhibitor gene of hereditary angioedema patients. (11139243)
2001
44
Angioedema due to losartan. (10492494)
1999
45
Angioedema due to ACE inhibitors: increased risk in patients of African origin. (10594491)
1999
46
ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema. (9793599)
1998
47
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
48
Hereditary angioedema. Description of a pediatric case]. (1791801)
1991
49
Angioedema from angiotensin converting enzyme inhibitors: a cause of upper airway obstruction. (2233075)
1990
50
Allergic urticaria and hereditary angioedema. Independent association in the same patient. (6509770)
1984

Variations for Angioedema

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Expression for genes affiliated with Angioedema

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Search GEO for disease gene expression data for Angioedema.

Pathways for genes affiliated with Angioedema

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Pathways related to Angioedema according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7F12, SERPING1
2
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.7SERPING1, C1S
39.7C1S, SERPING1
4
Show member pathways
9.6ACE, CPN1
5
Show member pathways
9.5KNG1, SERPING1
6
Show member pathways
9.1KNG1, SERPING1, F12
7
Show member pathways
9.1KNG1, SERPING1, F12
8
Show member pathways
8.5ACE, KNG1, BDKRB2
9
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
7.8BDKRB2, KNG1, SERPING1, F12, C1S

Compounds for genes affiliated with Angioedema

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Compounds related to Angioedema according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1imidaprilat439.8ACE, KNG1
2enalaprilate439.8KNG1, ACE
3zofenoprilat439.8KNG1, ACE
4capoten439.7KNG1, ACE
5moexiprilat439.7ACE, KNG1
6delapril439.7ACE, KNG1
7fosinoprilat439.7ACE, KNG1
8perindoprilat439.7ACE, KNG1
9imidapril43 4910.7ACE, KNG1
10lacidipine439.7ACE, KNG1
11an 69439.7KNG1, ACE
12saralasin439.7KNG1, ACE
13eprosartan43 28 1211.6KNG1, ACE
14omapatrilat439.6ACE, KNG1
15cilazapril43 1210.6ACE, KNG1
16trandolapril43 1210.6ACE, KNG1
17isosorbide dinitrate43 49 1211.6KNG1, ACE
18quinapril43 49 1211.6ACE, KNG1
19ramipril43 1210.4KNG1, ACE
20cereport439.4KNG1, BDKRB2
21fr17365743 2810.4KNG1, BDKRB2
22fr19099743 2810.4KNG1, BDKRB2
23lys-[des-arg9]bradykinin599.4KNG1, BDKRB2
24win 64338 hydrochloride599.4KNG1, BDKRB2
25r 715599.4KNG1, BDKRB2
26hoe 140599.4KNG1, BDKRB2
27thiorphan43 28 1211.4KNG1, ACE
28des-arg(10)-kallidin439.4KNG1, BDKRB2
29mepyramine43 1210.2BDKRB2, KNG1
30prostacyclin439.1KNG1, ACE, C1S
31perindopril43 49 1211.0KNG1, ACE
32n(g)-nitro-l-arginine methyl ester439.0BDKRB2, KNG1
33quinaprilat439.0BDKRB2, KNG1, ACE
34heparin43 28 24 1212.0C1S, F12, SERPING1, KNG1
35ramiprilat439.0ACE, KNG1, BDKRB2
36icatibant43 28 1211.0BDKRB2, KNG1, ACE
37kallidin43 289.9BDKRB2, KNG1, ACE
38enalaprilat438.9ACE, KNG1, BDKRB2
39lisinopril43 49 24 1211.9BDKRB2, KNG1, ACE
40candesartan43 49 28 1211.9ACE, KNG1, BDKRB2
41aprotinin43 129.9C1S, KNG1, BDKRB2
42captopril43 59 49 28 1212.9ACE, KNG1, BDKRB2
43aspirin43 49 28 2411.9KNG1, ACE, F12, C1S
44losartan43 49 28 1211.9BDKRB2, KNG1, ACE
45nifedipine43 28 49 1211.8BDKRB2, KNG1, ACE
46bradykinin59 28 2410.6BDKRB2, KNG1, ACE, F12
47arginine438.2C1S, CPN1, KNG1, BDKRB2
48kininogen438.1C1S, F12, ACE, KNG1, BDKRB2
49serine438.0C1S, F12, SERPING1, KNG1, BDKRB2
50nitric oxide43 24 1210.0C1S, ACE, KNG1, BDKRB2

GO Terms for genes affiliated with Angioedema

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Cellular components related to Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.4KNG1, SERPING1
2blood microparticleGO:00725629.2KNG1, SERPING1, C1S
3extracellular spaceGO:00056158.8F12, SERPING1, CPN1, ACE
4extracellular regionGO:00055768.2C1S, F12, SERPING1, ACE, KNG1
5extracellular vesicular exosomeGO:00700628.2SERPING1, ACE, XPNPEP2, KNG1
6plasma membraneGO:00058867.6BDKRB2, KNG1, XPNPEP2, ACE, F12

Biological processes related to Angioedema according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:00427309.8F12, SERPING1
2complement activation, classical pathwayGO:00069589.6SERPING1, C1S
3platelet degranulationGO:00025769.5KNG1, SERPING1
4arachidonic acid secretionGO:00504829.3BDKRB2, ACE
5blood coagulation, intrinsic pathwayGO:00075979.3KNG1, SERPING1, F12
6blood circulationGO:00080159.3BDKRB2, SERPING1
7regulation of vasoconstrictionGO:00192299.2BDKRB2, ACE
8vasodilationGO:00423119.2KNG1, BDKRB2
9smooth muscle contractionGO:00069399.2BDKRB2, KNG1
10blood coagulationGO:00075968.8F12, SERPING1, KNG1

Molecular functions related to Angioedema according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:00082379.1XPNPEP2, ACE
2protein bindingGO:00055157.3BDKRB2, KNG1, ACE, SERPING1, F12, C1S

Products for genes affiliated with Angioedema

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Sources for Angioedema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet