MCID: ANG015
MIFTS: 54

Angioedema malady

Summaries for Angioedema

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Angioedema (BE: angiooedema) or Quincke\'s edema is the rapid swelling (edema) of the dermis,... more...

MalaCards: Angioedema, also known as angioneurotic oedema, is related to hereditary angioedema and urticaria. An important gene associated with Angioedema is SERPING1 (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1), and among its related pathways are Common Pathway and Platelet degranulation . The drug fluoxymesterone and the compounds moexiprilat and enalaprilate have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotype cardiovascular system.

Aliases & Classifications for Angioedema

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

angioedema 8 10 45 61
angioneurotic oedema 8
angioneurotic edema 8
quincke's edema 8
giant urticaria 8


External Ids:

Disease Ontology8 DOID:1558
MeSH35 D000799
ICD1025 T78.3

Related Diseases for Angioedema

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Angioedema family:

acquired angioedema acquired angioedema type 1
acquired angioedema type 2

Diseases related to Angioedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary angioedema31.8C1S, BDKRB2, C4B, KNG1, F12, SERPING1
2urticaria31.1LTC4S, F12, KNG1, XPNPEP2, HNMT, C1S
3stroke, ischemic30.4F5
4acute pancreatitis30.1PRSS2, C1S
5c1 inhibitor deficiency30.1KRTAP10-9, F12, KNG1, SERPING1
6arthritis30.1KNG1
7vasculitis30.0C1S
8atherosclerosis30.0ACE, AGTR2, KNG1
9sinusitis29.8LTC4S
10thromboembolism29.8F5, F12
11purpura fulminans29.8F5
12acquired angioedema10.8
13vibratory angioedema10.4
14angioedema induced by ace inhibitors10.4
15angioedema, hereditary, types i and ii10.4
16hereditary angioedema type iii10.4
17herpes gestationis10.2
18systemic lupus erythematosus10.2
19hereditary lymphedema10.1
20lymphangitis10.1
21angiodysplasia10.1
22hereditary coproporphyria10.1
23spondylarthropathy10.1
24meige lymphedema10.1
25allergic urticaria10.1
26carcinoid syndrome10.1
27hereditary pancreatitis10.1
28hypocomplementemic urticarial vasculitis syndrome10.1
29h. pylori infection10.1
30blepharochalasis10.0
31loiasis10.0
32psoriatic arthritis10.0
33celiac disease10.0
34autoimmune hemolytic anemia10.0
35adult-onset still's disease10.0
36hepatitis a10.0
37allergic contact dermatitis10.0
38macroglossia10.0
39eosinophilic fasciitis10.0
40genetic urticaria10.0
41discoid lupus erythematosus10.0
42acquired angioedema type 110.0
43acquired angioedema type 210.0
44glomerulonephritis10.0KNG1
45rhinitis10.0KNG1
46acute myocardial infarction10.0ACE, SERPING1
47retinal vein occlusion10.0F5
48cerebrovascular disease10.0ACE, F12
49factor xii deficiency10.0F12, F5
50primary hyperoxaluria10.0KNG1

Graphical network of the top 20 diseases related to Angioedema:



Diseases related to angioedema

Clinical Features for Angioedema

Drugs & Therapeutics for Angioedema

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Angioedema

Drug clinical trials:

Search ClinicalTrials for Angioedema

Search NIH Clinical Center for Angioedema

Search CenterWatch for Angioedema

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Angioedema

Anatomical Context for Angioedema

Sources:
33MalaCards
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MalaCards organs/tissues related to Angioedema:

33
Skin, Liver, Tongue, Brain, Lung, Heart, Small intestine, Colon, Thyroid, Breast, Myeloid, T cells, B cells, Endothelial

Animal Models for Angioedema or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Angioedema:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.0SERPING1, ACE, SLC4A3, LTC4S, AGTR2, F5

Publications for Angioedema

Sources:
51PubMed
See all sources

Articles related to Angioedema:

(show top 50)    (show all 1037)
idTitleAuthorsYear
1
Urticaria and angioedema in pregnancy and lactation. (24262695)
2014
2
Depression and anxiety in patients with hereditary angioedema. (24428960)
2013
3
Bradykinin-mediated angioedema: factors prompting ED visits. (22944544)
2013
4
Cost-utility analysis of Ruconest(Ar) (conestat alfa) compared to Berinert(Ar) P (human C1 esterase inhibitor) in the treatment of acute, life-threatening angioedema attacks in patients with hereditary angioedema. (24278067)
2013
5
Hereditary angioedema: first report of the Brazilian registry and challenges. (22882421)
2013
6
Angioedema after the first dose of metformin. (23380117)
2013
7
Overview of hereditary angioedema caused by C1-inhibitor deficiency: assessment and clinical management. (23678554)
2013
8
Successful treatment of a facial attack of angioedema with icatibant in a patient with idiopathic angioedema. (23706583)
2013
9
Factors associated with hospitalization of patients with angiotensin-converting enzyme inhibitor-induced angioedema. (23676576)
2013
10
Role of the B1 bradykinin receptor and gC1qR/p33 in angioedema. (24176217)
2013
11
Hereditary angioedema nationwide study in Slovenia reveals four novel mutations in SERPING1 gene. (23437219)
2013
12
Delayed takotsubo cardiomyopathy caused by excessive exogenous epinephrine administration after the treatment of angioedema. (22754120)
2012
13
WAO Guideline for the Management of Hereditary Angioedema. (23282420)
2012
14
Commentary on the recorded history of angioedema. (22370537)
2012
15
Novel and recurrent C1 inhibitor gene mutations in nine Japanese patients with hereditary angioedema. (22831796)
2012
16
Strong correlation of high EBNA-1-IgG levels with edematous attacks involving upper airway mucosa in hereditary angioedema due to C1-inhibitor deficiency. (22142940)
2012
17
Transient small bowel angioedema due to intravenous iodinated contrast media. (22408362)
2012
18
Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database. (23033229)
2012
19
Update on the acute treatment of hereditary angioedema. (21262093)
2011
20
Urticaria and angioedema. (21913206)
2011
21
Successful long-term treatment with the bradykinin B2 receptor antagonist icatibant in a patient with hereditary angioedema. (21950301)
2011
22
Hereditary angioedema therapy: kallikrein inhibition and bradykinin receptor antagonism. (23282868)
2010
23
Introduction: New Perspectives in Hereditary Angioedema (HAE): Molecular Mechanisms & Therapeutic Choices: A CME Symposium Presented at the 2009 World Allergy Congress, Buenos Aires, Argentina, December 9, 2009. (23282865)
2010
24
FDA approves kallikrein inhibitor to treat hereditary angioedema. (20065259)
2010
25
Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor. (20667118)
2010
26
Complement disorders and hereditary angioedema. (20176263)
2010
27
The bradykinin-forming cascade and its role in hereditary angioedema. (20377108)
2010
28
Allergic contact stomatitis to cinnamon in chewing gum mistaken as facial angioedema. (19804442)
2010
29
Hereditary angioedema consensus 2010. (20667116)
2010
30
Icatibant for hereditary angioedema. (20135020)
2009
31
Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiency. (19076541)
2009
32
Hereditary angioedema caused by missense mutations in the factor XII gene: clinical features, trigger factors, and therapy. (19477491)
2009
33
Modern preoperative and intraoperative management of hereditary angioedema. (19368763)
2009
34
Psychometric validation of two patient-reported outcome measures to assess symptom severity and changes in symptoms in hereditary angioedema. (19597964)
2009
35
Disease expression in women with hereditary angioedema. (18554570)
2008
36
Long-term danazol prophylaxis does not lead to increased carotid intima-media thickness in hereditary angioedema patients. (17977544)
2008
37
Acquired angioedema in non-Hodgkin's lymphoma. (17317233)
2007
38
Hereditary angioedema-a forgotten cause of the 'medical' acute abdomen. (17047969)
2007
39
Novel pharmacotherapy of acute hereditary angioedema with bradykinin B2-receptor antagonist icatibant. (17073887)
2006
40
Angioedema due to ACE inhibitors and AT(1) receptor antagonists]. (16240152)
2006
41
Oxandrolone treatment of childhood hereditary angioedema. (15049404)
2004
42
Angiotensin-converting enzyme inhibitor related angioedema and the anaesthetist. (14984528)
2004
43
An 89-year-old woman with angioedema during t-PA infusion for acute ischemic stroke. (12660697)
2003
44
Angioedema associated with candesartan. (12222554)
2002
45
C1-esterase inhibitor in ACE inhibitor-induced severe angioedema of the tongue]. (11712230)
2001
46
Unusual manifestations of hereditary angioedema. (11132070)
2000
47
Protein sgp 120 as a marker of an acquired angioedema. (11029608)
2000
48
A 'de novo' arisen case of angioedema C1-inhibitor deficiency dependent: possible mutagenic effect of azathioprine? (10424251)
1999
49
Angioedema: the role of ACE inhibitors and factors associated with poor clinical outcome. (9290997)
1997
50
Angioedema due to medication treatment]. (11921960)
1996

Genetic Variations for Angioedema

Expression for genes affiliated with Angioedema

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Angioedema

Search GEO for disease gene expression data for Angioedema.

Pathways for genes affiliated with Angioedema

Sources:
54Reactome, 52QIAGEN, 30KEGG, 56SinoBiological, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 53R&D Systems
See all sources

Compounds for genes affiliated with Angioedema

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Angioedema according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1moexiprilat4510.8KNG1, ACE
2enalaprilate4510.7KNG1, ACE
3quinaprilat4510.7BDKRB2, KNG1, ACE
4capoten4510.7ACE, KNG1
5ramiprilat4510.7KNG1, BDKRB2, ACE
6zofenoprilat4510.7ACE, KNG1
7cereport4510.7BDKRB2, KNG1
8icatibant45 29 1112.7BDKRB2, KNG1, ACE
9imidaprilat4510.7KNG1, ACE
10fr17365745 2911.7BDKRB2, KNG1
11kallidin45 2911.7BDKRB2, ACE, KNG1
12fr19099745 2911.7BDKRB2, KNG1
13saralasin4510.7AGTR2, ACE, KNG1
14enalaprilat4510.7BDKRB2, KNG1, ACE
15captopril45 29 50 60 1114.7KNG1, AGTR2, BDKRB2
16lys-[des-arg9]bradykinin6010.7KNG1, BDKRB2
17lisinopril45 11 2412.7BDKRB2, KNG1, ACE
18win 64338 hydrochloride6010.7BDKRB2, KNG1
19delapril4510.7KNG1, ACE
20bradykinin60 29 2412.7BDKRB2, F12, KNG1, ACE
21r 7156010.7BDKRB2, KNG1
22hoe 1406010.7KNG1, BDKRB2
23aprotinin45 1111.7C1S, F5, KLK1, BDKRB2
24fosinoprilat4510.7ACE, KNG1
25candesartan45 29 1112.7ACE, AGTR2, KNG1, BDKRB2
26perindoprilat4510.7KNG1, ACE
27des-arg(10)-kallidin4510.7KNG1, BDKRB2
28enalapril45 50 1112.6KNG1, AGTR2, ACE
29losartan45 50 29 1113.6KNG1, AGTR2, ACE, BDKRB2
30imidapril4510.6ACE, KNG1
31serine4510.6BDKRB2, F12, SERPING1, KNG1, KLK1
32lacidipine4510.6KNG1, ACE
33prostacyclin4510.6F5, C1S, KNG1, AGTR2, ACE
34nafamostat mesilate4510.6KNG1, F5
35ang ii4510.6ACE, KNG1, AGTR2
36heparin45 29 11 2413.6SERPING1, KNG1, F12, C4B, C1S, F5
37angiotensin ii29 2411.5AGTR2, ACE
38an 694510.5ACE, KNG1
39kininogen4510.5F5, ACE, KNG1, F12, BDKRB2, KLK1
40kaolin4510.5F12, F5
41aspirin45 50 29 2413.5HNMT, F5, KNG1, F12, LTC4S, ACE
42eprosartan45 29 1112.5ACE, KNG1
43arginine4510.5C1S, KLK1, BDKRB2, F5, KNG1, AGTR2
44omapatrilat4510.4ACE, KNG1
45trandolapril45 1111.4KNG1, ACE
46nitric oxide45 11 2412.4AGTR2, C1S, ACE, KNG1, BDKRB2, F5
47anthranilate4510.4KLK1, KNG1
48pd12331945 2911.2AGTR2, ACE
49calcium45 50 11 2413.2F5, KNG1, AGTR2, LTC4S, C4B, PRSS2
50cilazapril45 1111.1KNG1, ACE

GO Terms for genes affiliated with Angioedema

Sources:
16Gene Ontology
See all sources

Cellular components related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3SERPING1, KNG1, F5
2extracellular spaceGO:0056159.7C4B, F5, KNG1, F12, PRSS2, ACE
3extracellular regionGO:0055769.7SERPING1, C1R, C1S, C4B, F5, KNG1

Biological processes related to Angioedema according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:00759710.6SERPING1, KNG1, F12
2blood circulationGO:00801510.5F5, SERPING1, BDKRB2
3complement activation, classical pathwayGO:00695810.5C1S, C1R, C4B, SERPING1
4complement activationGO:00695610.5C1S, C4B, C1R
5platelet degranulationGO:00257610.5SERPING1, F5, KNG1
6arachidonic acid secretionGO:05048210.4BDKRB2, ACE
7fibrinolysisGO:04273010.4F12, SERPING1
8positive regulation of renal sodium excretionGO:03581510.4KNG1, AGTR2
9inflammatory responseGO:00695410.3AGTR2, KNG1, C4B, BDKRB2
10innate immune responseGO:04508710.3F12, SERPING1, C4B, C1S, C1R, PRSS2
11regulation of vasoconstrictionGO:01922910.3ACE, BDKRB2
12proteolysisGO:00650810.3C1R, C1S, KLK1, XPNPEP2, F12, PRSS2
13vasodilationGO:04231110.1KNG1, BDKRB2

Molecular functions related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.9PRSS2, F12, KLK1, C1S
2protein bindingGO:0055159.7C1S, BDKRB2, F5, KNG1, F12, PRSS2

Products for genes affiliated with Angioedema

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angioedema

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet