MCID: ANG015
MIFTS: 57

Angioedema malady

Genetic diseases, Skin diseases, Rare diseases, Bone diseases, Immune diseases categories
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Summaries for Angioedema

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65Wikipedia, 33MalaCards
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Wikipedia:65 Angioedema (BE: angiooedema) or Quincke\'s edema is the rapid swelling (edema) of the dermis,... more...

MalaCards: Angioedema, also known as angioneurotic oedema, is related to hereditary angioedema and c1 inhibitor deficiency. An important gene associated with Angioedema is SERPING1 (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1), and among its related pathways are Cell adhesion Plasmin signaling and Complement Pathway. The drug fluoxymesterone and the compounds imidaprilat and enalaprilate have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and endothelial.

Aliases & Classifications for Angioedema

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 25ICD10
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Classifications:



Aliases & Descriptions:

angioedema 8 10 45 62
angioneurotic oedema 8
angioneurotic edema 8
quincke's edema 8
giant urticaria 8


External Ids:

Disease Ontology8 DOID:1558
MeSH35 D000799
ICD1025 T78.3

Related Diseases for Angioedema

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17GeneCards, 18GeneDecks
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Diseases in the Angioedema, Hereditary, Types I and Ii family:

Hereditary Angioedema angioedema
Acquired Angioedema Hereditary Angioedema Type Iii
Acquired Angioedema Type 1 Acquired Angioedema Type 2

Diseases related to Angioedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary angioedema31.7C1S, F12, SERPING1, KNG1, BDKRB2
2c1 inhibitor deficiency30.9F12, SERPING1, KNG1
3urticaria30.9C1S, F12, SERPING1, ACE, XPNPEP2, KNG1
4pancreatitis30.1KNG1, C1S
5ischemia29.9C1S, KNG1, BDKRB2
6acquired angioedema10.8
7eosinophilia10.5
8hereditary angioedema type iii10.5
9angioedema induced by ace inhibitors10.4
10vibratory angioedema10.4
11laryngitis10.4
12angioedema, hereditary, types i and ii10.4
13lupus erythematosus10.3
14herpes gestationis10.2
15systemic lupus erythematosus10.2
16endotheliitis10.2
17angiodysplasia10.2
18lymphangitis10.2
19ludwig's angina10.2
20hereditary lymphedema10.2
21hereditary coproporphyria10.2
22lymphedema10.2
23spondylarthropathy10.2
24acute pancreatitis10.1
25arthritis10.1
26dermatitis10.1
27hypertension10.1
28thyroiditis10.1
29carcinoid syndrome10.1
30hypocomplementemic urticarial vasculitis syndrome10.1
31acquired angioedema type 210.1
32capillary leak syndrome10.1C1S, SERPING1
33cerebrovascular disease10.0F12, ACE
34renal hypertension10.0ACE, KNG1
35crohn's disease10.0
36blepharochalasis10.0
37allergic urticaria10.0
38celiac disease10.0
39autoimmune hemolytic anemia10.0
40loiasis10.0
41psoriatic arthritis10.0
42adult-onset still's disease10.0
43allergic contact dermatitis10.0
44atherosclerosis10.0
45cheilitis10.0
46chronic lymphocytic leukemia10.0
47contact dermatitis10.0
48fasciitis10.0
49food allergy10.0
50hemolytic anemia10.0

Graphical network of the top 20 diseases related to Angioedema:



Diseases related to angioedema

Symptoms for Angioedema

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Drugs & Therapeutics for Angioedema

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Angioedema

Search NIH Clinical Center for Angioedema

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Angioedema

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Anatomical Context for Angioedema

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33MalaCards
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MalaCards organs/tissues related to Angioedema:

33
Tongue, Skin, Endothelial, Testes, Thyroid, Heart, Small intestine, Colon, Brain, B cells, Myeloid, Liver, Breast, Lung, Eye

Animal Models for Angioedema or affiliated genes

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Publications for Angioedema

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52PubMed
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Articles related to Angioedema:

(show top 50)    (show all 1020)
idTitleAuthorsYear
1
Anaphylaxis/angioedema caused by honey ingestion. (24433600)
2014
2
Depression and anxiety in patients with hereditary angioedema. (24428960)
2013
3
The development of angioedema in a patient with type 2 diabetes due to a novel dipeptidyl peptidase-IV inhibitor, anagliptin. (23972359)
2013
4
Hereditary angioedema: epidemiology, management, and role of icatibant. (23662043)
2013
5
Onset of Orolingual Angioedema After Treatment of Acute Brain Ischemia with Alteplase Depends on the Site of Brain Ischemia: A Meta-analysis. (24350070)
2013
6
Diagnosing angioedema. (24176210)
2013
7
The burden of illness in patients with hereditary angioedema. (24125136)
2013
8
Recent advances in hereditary angioedema self-administration treatment: summary of an International Hereditary Angioedema Expert Meeting. (23689237)
2013
9
Practical algorithm for diagnosing patients with recurrent wheals or angioedema. (23646863)
2013
10
Management of hereditary angioedema in 2012: scientific and pharmacoeconomic perspectives. (23352523)
2013
11
Hereditary angioedema: not an allergy. (23248378)
2012
12
Prospective, double-blind, placebo-controlled trials of ecallantide for acute attacks of hereditary angioedema. (22149337)
2012
13
Hereditary angioedema: short-term prophylaxis for surgery. (22856630)
2012
14
Efficacy assessments in randomized controlled studies of acute therapy for hereditary angioedema. (22797816)
2012
15
Type III hereditary angioedema: defined, but not understood. (22920066)
2012
16
Successful C1 esterase inhibitor therapy in a child with a novel type 3 hereditary angioedema-like syndrome. (22626603)
2012
17
Hereditary angioedema: a survey of UK emergency departments and recommendations for management. (22008588)
2012
18
Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema. (22994404)
2012
19
Isolated angioedema of the bowel due to C1 esterase inhibitor deficiency: a case report and review of literature. (21320328)
2011
20
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
21
Hereditary angioedema: an instructive model of clinical description, molecular discovery, and development of new effective treatments. (22195754)
2011
22
In brief: icatibant (Firazyr) for hereditary angioedema. (22113125)
2011
23
Update on preventive therapy (prophylaxis) of hereditary angioedema. (21262094)
2011
24
Hereditary angioedema therapy: kallikrein inhibition and bradykinin receptor antagonism. (23282868)
2010
25
Summary and Conclusions: New Perspectives in Hereditary Angioedema: Molecular Mechanisms and Therapeutic Choices: A CME Symposium Presented at the World Allergy Congress, Buenos Aires, Argentina (December 2009). (23282869)
2010
26
Response time for ecallantide treatment of acute hereditary angioedema attacks. (21130380)
2010
27
Pathogenesis and laboratory diagnosis of hereditary angioedema. (19843402)
2009
28
Icatibant for hereditary angioedema. (20135020)
2009
29
Hereditary angioedema and pregnancy. (19281571)
2009
30
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? (20163043)
2009
31
Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiency. (19076541)
2009
32
Acute edema blisters in a hereditary angioedema cutaneous attack. (18680708)
2008
33
Orolingual angioedema as complication after rt-PA in stroke patient treated with ACE inhibitor]. (18453163)
2008
34
Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients. (18320917)
2008
35
Treatment of hereditary angioedema with plasma-derived C1 inhibitor. (19209279)
2008
36
Hereditary angioedema: new hopes for an orphan disease. (19160940)
2008
37
Not all ACE inhibitor related angioedema is always evident: a case which is misdiagnosed as panic attack and speech disorder. (18047821)
2007
38
Hereditary angioedema associated with heterozygous factor V Leiden mutation in a patient with Purpura fulminans. (17068406)
2007
39
Haploinsufficiency due to deletion within the 3'-UTR of C1-INH-gene associated with hereditary angioedema. (16617246)
2006
40
Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema. (15053206)
2004
41
Angioedema associated with angiotensin-converting enzyme inhibitor use: outcome after switching to a different treatment. (15111379)
2004
42
Clinical and biological distinctions between type I and type II acquired angioedema. (14553889)
2003
43
Rapid detection by fluorescent multiplex PCR of exon deletions and duplications in the C1 inhibitor gene of hereditary angioedema patients. (11139243)
2001
44
Angioedema due to losartan. (10492494)
1999
45
Angioedema due to ACE inhibitors: increased risk in patients of African origin. (10594491)
1999
46
ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema. (9793599)
1998
47
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
48
Hereditary angioedema. Description of a pediatric case]. (1791801)
1991
49
Angioedema from angiotensin converting enzyme inhibitors: a cause of upper airway obstruction. (2233075)
1990
50
Allergic urticaria and hereditary angioedema. Independent association in the same patient. (6509770)
1984

Variations for Angioedema

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Expression for genes affiliated with Angioedema

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angioedema

Search GEO for disease gene expression data for Angioedema.

Pathways for genes affiliated with Angioedema

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50PathCards, 60Thomson Reuters, 53QIAGEN, 55Reactome, 57SinoBiological, 30KEGG, 38NCBI BioSystems Database, 54R&D Systems, 51PharmGKB
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Pathways related to Angioedema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7F12, SERPING1
2
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.7SERPING1, C1S
39.7C1S, SERPING1
4
Show member pathways
9.6ACE, CPN1
5
Show member pathways
9.5KNG1, SERPING1
6
Show member pathways
9.1KNG1, SERPING1, F12
7
Show member pathways
9.1KNG1, SERPING1, F12
8
Show member pathways
8.5ACE, KNG1, BDKRB2
9
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
7.8BDKRB2, KNG1, SERPING1, F12, C1S

Compounds for genes affiliated with Angioedema

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45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Angioedema according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1imidaprilat459.8ACE, KNG1
2enalaprilate459.8KNG1, ACE
3zofenoprilat459.8KNG1, ACE
4capoten459.7KNG1, ACE
5moexiprilat459.7ACE, KNG1
6delapril459.7ACE, KNG1
7fosinoprilat459.7ACE, KNG1
8perindoprilat459.7ACE, KNG1
9imidapril45 5110.7ACE, KNG1
10lacidipine459.7ACE, KNG1
11an 69459.7KNG1, ACE
12saralasin459.7KNG1, ACE
13eprosartan45 29 1111.6KNG1, ACE
14omapatrilat459.6ACE, KNG1
15cilazapril45 1110.6ACE, KNG1
16trandolapril45 1110.6ACE, KNG1
17isosorbide dinitrate45 51 1111.6KNG1, ACE
18quinapril45 51 1111.6ACE, KNG1
19ramipril45 1110.4KNG1, ACE
20cereport459.4KNG1, BDKRB2
21fr17365745 2910.4KNG1, BDKRB2
22fr19099745 2910.4KNG1, BDKRB2
23lys-[des-arg9]bradykinin619.4KNG1, BDKRB2
24win 64338 hydrochloride619.4KNG1, BDKRB2
25r 715619.4KNG1, BDKRB2
26hoe 140619.4KNG1, BDKRB2
27thiorphan45 29 1111.4KNG1, ACE
28des-arg(10)-kallidin459.4KNG1, BDKRB2
29mepyramine45 1110.2BDKRB2, KNG1
30prostacyclin459.1KNG1, ACE, C1S
31perindopril45 51 1111.0KNG1, ACE
32n(g)-nitro-l-arginine methyl ester459.0BDKRB2, KNG1
33quinaprilat459.0BDKRB2, KNG1, ACE
34heparin45 29 24 1112.0C1S, F12, SERPING1, KNG1
35ramiprilat459.0ACE, KNG1, BDKRB2
36icatibant45 29 1111.0BDKRB2, KNG1, ACE
37kallidin45 299.9BDKRB2, KNG1, ACE
38enalaprilat458.9ACE, KNG1, BDKRB2
39lisinopril45 51 24 1111.9BDKRB2, KNG1, ACE
40candesartan45 51 29 1111.9ACE, KNG1, BDKRB2
41aprotinin45 119.9C1S, KNG1, BDKRB2
42captopril45 61 51 29 1112.9ACE, KNG1, BDKRB2
43aspirin45 51 29 2411.9KNG1, ACE, F12, C1S
44losartan45 51 29 1111.9BDKRB2, KNG1, ACE
45nifedipine45 29 51 1111.8BDKRB2, KNG1, ACE
46bradykinin61 29 2410.6BDKRB2, KNG1, ACE, F12
47arginine458.2C1S, CPN1, KNG1, BDKRB2
48kininogen458.1C1S, F12, ACE, KNG1, BDKRB2
49serine458.0C1S, F12, SERPING1, KNG1, BDKRB2
50nitric oxide45 24 1110.0C1S, ACE, KNG1, BDKRB2

GO Terms for genes affiliated with Angioedema

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16Gene Ontology
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Cellular components related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4KNG1, SERPING1
2blood microparticleGO:0725629.2KNG1, SERPING1, C1S
3extracellular spaceGO:0056158.8F12, SERPING1, CPN1, ACE
4extracellular regionGO:0055768.2C1S, F12, SERPING1, ACE, KNG1
5extracellular vesicular exosomeGO:0700628.2SERPING1, ACE, XPNPEP2, KNG1
6plasma membraneGO:0058867.6BDKRB2, KNG1, XPNPEP2, ACE, F12

Biological processes related to Angioedema according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.8F12, SERPING1
2complement activation, classical pathwayGO:0069589.6SERPING1, C1S
3platelet degranulationGO:0025769.5KNG1, SERPING1
4arachidonic acid secretionGO:0504829.3BDKRB2, ACE
5blood coagulation, intrinsic pathwayGO:0075979.3KNG1, SERPING1, F12
6blood circulationGO:0080159.3BDKRB2, SERPING1
7regulation of vasoconstrictionGO:0192299.2BDKRB2, ACE
8vasodilationGO:0423119.2KNG1, BDKRB2
9smooth muscle contractionGO:0069399.2BDKRB2, KNG1
10blood coagulationGO:0075968.8F12, SERPING1, KNG1

Molecular functions related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:0082379.1XPNPEP2, ACE
2protein bindingGO:0055157.3BDKRB2, KNG1, ACE, SERPING1, F12, C1S

Products for genes affiliated with Angioedema

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Sources for Angioedema

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet