MCID: ANG015
MIFTS: 57

Angioedema malady

Genetic diseases, Skin diseases, Rare diseases, Bone diseases, Immune diseases categories

Summaries for Angioedema

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Angioedema (BE: angiooedema) or Quincke\'s edema is the rapid swelling (edema) of the dermis,... more...

MalaCards: Angioedema, also known as angioneurotic oedema, is related to hereditary angioedema and c1 inhibitor deficiency. An important gene associated with Angioedema is SERPING1 (serpin peptidase inhibitor, clade G (C1 inhibitor), member 1), and among its related pathways are Cell adhesion Plasmin signaling and Complement Pathway. The drug fluoxymesterone and the compounds imidaprilat and enalaprilate have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and endothelial.

Aliases & Classifications for Angioedema

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 26ICD10
See all sources

Classifications:



Aliases & Descriptions:

angioedema 9 11 46 63
angioneurotic oedema 9
angioneurotic edema 9
quincke's edema 9
giant urticaria 9


External Ids:

Disease Ontology9 DOID:1558
MeSH36 D000799
ICD1026 T78.3

Related Diseases for Angioedema

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Angioedema, Hereditary, Types I and Ii family:

Hereditary Angioedema angioedema
Acquired Angioedema Hereditary Angioedema Type Iii
Acquired Angioedema Type 1 Acquired Angioedema Type 2

Diseases related to Angioedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary angioedema31.7C1S, F12, SERPING1, KNG1, BDKRB2
2c1 inhibitor deficiency30.9F12, SERPING1, KNG1
3urticaria30.9C1S, F12, SERPING1, ACE, XPNPEP2, KNG1
4pancreatitis30.1KNG1, C1S
5ischemia29.9C1S, KNG1, BDKRB2
6acquired angioedema10.8
7eosinophilia10.5
8hereditary angioedema type iii10.5
9angioedema induced by ace inhibitors10.4
10vibratory angioedema10.4
11laryngitis10.4
12angioedema, hereditary, types i and ii10.4
13lupus erythematosus10.3
14herpes gestationis10.2
15systemic lupus erythematosus10.2
16endotheliitis10.2
17angiodysplasia10.2
18lymphangitis10.2
19ludwig's angina10.2
20hereditary lymphedema10.2
21hereditary coproporphyria10.2
22lymphedema10.2
23spondylarthropathy10.2
24acute pancreatitis10.1
25arthritis10.1
26dermatitis10.1
27hypertension10.1
28thyroiditis10.1
29carcinoid syndrome10.1
30hypocomplementemic urticarial vasculitis syndrome10.1
31acquired angioedema type 210.1
32capillary leak syndrome10.1C1S, SERPING1
33cerebrovascular disease10.0F12, ACE
34renal hypertension10.0ACE, KNG1
35crohn's disease10.0
36blepharochalasis10.0
37allergic urticaria10.0
38celiac disease10.0
39autoimmune hemolytic anemia10.0
40loiasis10.0
41psoriatic arthritis10.0
42adult-onset still's disease10.0
43allergic contact dermatitis10.0
44atherosclerosis10.0
45cheilitis10.0
46chronic lymphocytic leukemia10.0
47contact dermatitis10.0
48fasciitis10.0
49food allergy10.0
50hemolytic anemia10.0

Graphical network of the top 20 diseases related to Angioedema:



Diseases related to angioedema

Symptoms for Angioedema

About this section

Drugs & Therapeutics for Angioedema

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Angioedema

Drug clinical trials:

Search ClinicalTrials for Angioedema

Search NIH Clinical Center for Angioedema

Search CenterWatch for Angioedema

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Angioedema

About this section

Anatomical Context for Angioedema

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Angioedema:

34
Tongue, Skin, Endothelial, Testes, Thyroid, Heart, Small intestine, Colon, Brain, B cells, Myeloid, Liver, Breast, Lung, Eye

Animal Models for Angioedema or affiliated genes

About this section

Publications for Angioedema

About this section
Sources:
53PubMed
See all sources

Articles related to Angioedema:

(show top 50)    (show all 1020)
idTitleAuthorsYear
1
Anaphylaxis/angioedema caused by honey ingestion. (24433600)
2014
2
Depression and anxiety in patients with hereditary angioedema. (24428960)
2013
3
The development of angioedema in a patient with type 2 diabetes due to a novel dipeptidyl peptidase-IV inhibitor, anagliptin. (23972359)
2013
4
Hereditary angioedema: epidemiology, management, and role of icatibant. (23662043)
2013
5
Onset of Orolingual Angioedema After Treatment of Acute Brain Ischemia with Alteplase Depends on the Site of Brain Ischemia: A Meta-analysis. (24350070)
2013
6
Diagnosing angioedema. (24176210)
2013
7
The burden of illness in patients with hereditary angioedema. (24125136)
2013
8
Recent advances in hereditary angioedema self-administration treatment: summary of an International Hereditary Angioedema Expert Meeting. (23689237)
2013
9
Practical algorithm for diagnosing patients with recurrent wheals or angioedema. (23646863)
2013
10
Management of hereditary angioedema in 2012: scientific and pharmacoeconomic perspectives. (23352523)
2013
11
Hereditary angioedema: not an allergy. (23248378)
2012
12
Prospective, double-blind, placebo-controlled trials of ecallantide for acute attacks of hereditary angioedema. (22149337)
2012
13
Hereditary angioedema: short-term prophylaxis for surgery. (22856630)
2012
14
Efficacy assessments in randomized controlled studies of acute therapy for hereditary angioedema. (22797816)
2012
15
Type III hereditary angioedema: defined, but not understood. (22920066)
2012
16
Successful C1 esterase inhibitor therapy in a child with a novel type 3 hereditary angioedema-like syndrome. (22626603)
2012
17
Hereditary angioedema: a survey of UK emergency departments and recommendations for management. (22008588)
2012
18
Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema. (22994404)
2012
19
Isolated angioedema of the bowel due to C1 esterase inhibitor deficiency: a case report and review of literature. (21320328)
2011
20
Successful treatment of an acute attack of acquired angioedema with the bradykinin-B2-receptor antagonist icatibant. (20477917)
2011
21
Hereditary angioedema: an instructive model of clinical description, molecular discovery, and development of new effective treatments. (22195754)
2011
22
In brief: icatibant (Firazyr) for hereditary angioedema. (22113125)
2011
23
Update on preventive therapy (prophylaxis) of hereditary angioedema. (21262094)
2011
24
Hereditary angioedema therapy: kallikrein inhibition and bradykinin receptor antagonism. (23282868)
2010
25
Summary and Conclusions: New Perspectives in Hereditary Angioedema: Molecular Mechanisms and Therapeutic Choices: A CME Symposium Presented at the World Allergy Congress, Buenos Aires, Argentina (December 2009). (23282869)
2010
26
Response time for ecallantide treatment of acute hereditary angioedema attacks. (21130380)
2010
27
Pathogenesis and laboratory diagnosis of hereditary angioedema. (19843402)
2009
28
Icatibant for hereditary angioedema. (20135020)
2009
29
Hereditary angioedema and pregnancy. (19281571)
2009
30
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? (20163043)
2009
31
Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiency. (19076541)
2009
32
Acute edema blisters in a hereditary angioedema cutaneous attack. (18680708)
2008
33
Orolingual angioedema as complication after rt-PA in stroke patient treated with ACE inhibitor]. (18453163)
2008
34
Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients. (18320917)
2008
35
Treatment of hereditary angioedema with plasma-derived C1 inhibitor. (19209279)
2008
36
Hereditary angioedema: new hopes for an orphan disease. (19160940)
2008
37
Not all ACE inhibitor related angioedema is always evident: a case which is misdiagnosed as panic attack and speech disorder. (18047821)
2007
38
Hereditary angioedema associated with heterozygous factor V Leiden mutation in a patient with Purpura fulminans. (17068406)
2007
39
Haploinsufficiency due to deletion within the 3'-UTR of C1-INH-gene associated with hereditary angioedema. (16617246)
2006
40
Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema. (15053206)
2004
41
Angioedema associated with angiotensin-converting enzyme inhibitor use: outcome after switching to a different treatment. (15111379)
2004
42
Clinical and biological distinctions between type I and type II acquired angioedema. (14553889)
2003
43
Rapid detection by fluorescent multiplex PCR of exon deletions and duplications in the C1 inhibitor gene of hereditary angioedema patients. (11139243)
2001
44
Angioedema due to losartan. (10492494)
1999
45
Angioedema due to ACE inhibitors: increased risk in patients of African origin. (10594491)
1999
46
ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema. (9793599)
1998
47
Human parvovirus infection: rheumatic manifestations, angioedema, C1 esterase inhibitor deficiency, ANA positivity, and possible onset of systemic lupus erythematosus. (8823689)
1996
48
Hereditary angioedema. Description of a pediatric case]. (1791801)
1991
49
Angioedema from angiotensin converting enzyme inhibitors: a cause of upper airway obstruction. (2233075)
1990
50
Allergic urticaria and hereditary angioedema. Independent association in the same patient. (6509770)
1984

Variations for Angioedema

About this section

Expression for genes affiliated with Angioedema

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Angioedema

Search GEO for disease gene expression data for Angioedema.

Pathways for genes affiliated with Angioedema

About this section
Sources:
51PathCards, 61Thomson Reuters, 54QIAGEN, 56Reactome, 58SinoBiological, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems, 52PharmGKB
See all sources

Pathways related to Angioedema according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7F12, SERPING1
2
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.7SERPING1, C1S
39.7C1S, SERPING1
4
Show member pathways
9.6ACE, CPN1
5
Show member pathways
9.5KNG1, SERPING1
6
Show member pathways
9.1KNG1, SERPING1, F12
7
Show member pathways
9.1KNG1, SERPING1, F12
8
Show member pathways
8.5ACE, KNG1, BDKRB2
9
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
7.8BDKRB2, KNG1, SERPING1, F12, C1S

Compounds for genes affiliated with Angioedema

About this section
Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 25HMDB
See all sources

Compounds related to Angioedema according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1imidaprilat469.8ACE, KNG1
2enalaprilate469.8KNG1, ACE
3zofenoprilat469.8KNG1, ACE
4capoten469.7KNG1, ACE
5moexiprilat469.7ACE, KNG1
6delapril469.7ACE, KNG1
7fosinoprilat469.7ACE, KNG1
8perindoprilat469.7ACE, KNG1
9imidapril46 5210.7ACE, KNG1
10lacidipine469.7ACE, KNG1
11an 69469.7KNG1, ACE
12saralasin469.7KNG1, ACE
13eprosartan46 30 1211.6KNG1, ACE
14omapatrilat469.6ACE, KNG1
15cilazapril46 1210.6ACE, KNG1
16trandolapril46 1210.6ACE, KNG1
17isosorbide dinitrate46 52 1211.6KNG1, ACE
18quinapril46 52 1211.6ACE, KNG1
19ramipril46 1210.4KNG1, ACE
20cereport469.4KNG1, BDKRB2
21fr17365746 3010.4KNG1, BDKRB2
22fr19099746 3010.4KNG1, BDKRB2
23lys-[des-arg9]bradykinin629.4KNG1, BDKRB2
24win 64338 hydrochloride629.4KNG1, BDKRB2
25r 715629.4KNG1, BDKRB2
26hoe 140629.4KNG1, BDKRB2
27thiorphan46 30 1211.4KNG1, ACE
28des-arg(10)-kallidin469.4KNG1, BDKRB2
29mepyramine46 1210.2BDKRB2, KNG1
30prostacyclin469.1KNG1, ACE, C1S
31perindopril46 52 1211.0KNG1, ACE
32n(g)-nitro-l-arginine methyl ester469.0BDKRB2, KNG1
33quinaprilat469.0BDKRB2, KNG1, ACE
34heparin46 30 25 1212.0C1S, F12, SERPING1, KNG1
35ramiprilat469.0ACE, KNG1, BDKRB2
36icatibant46 30 1211.0BDKRB2, KNG1, ACE
37kallidin46 309.9BDKRB2, KNG1, ACE
38enalaprilat468.9ACE, KNG1, BDKRB2
39lisinopril46 52 25 1211.9BDKRB2, KNG1, ACE
40candesartan46 52 30 1211.9ACE, KNG1, BDKRB2
41aprotinin46 129.9C1S, KNG1, BDKRB2
42captopril46 62 52 30 1212.9ACE, KNG1, BDKRB2
43aspirin46 52 30 2511.9KNG1, ACE, F12, C1S
44losartan46 52 30 1211.9BDKRB2, KNG1, ACE
45nifedipine46 30 52 1211.8BDKRB2, KNG1, ACE
46bradykinin62 30 2510.6BDKRB2, KNG1, ACE, F12
47arginine468.2C1S, CPN1, KNG1, BDKRB2
48kininogen468.1C1S, F12, ACE, KNG1, BDKRB2
49serine468.0C1S, F12, SERPING1, KNG1, BDKRB2
50nitric oxide46 25 1210.0C1S, ACE, KNG1, BDKRB2

GO Terms for genes affiliated with Angioedema

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4KNG1, SERPING1
2blood microparticleGO:0725629.2KNG1, SERPING1, C1S
3extracellular spaceGO:0056158.8F12, SERPING1, CPN1, ACE
4extracellular regionGO:0055768.2C1S, F12, SERPING1, ACE, KNG1
5extracellular vesicular exosomeGO:0700628.2SERPING1, ACE, XPNPEP2, KNG1
6plasma membraneGO:0058867.6BDKRB2, KNG1, XPNPEP2, ACE, F12

Biological processes related to Angioedema according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:0427309.8F12, SERPING1
2complement activation, classical pathwayGO:0069589.6SERPING1, C1S
3platelet degranulationGO:0025769.5KNG1, SERPING1
4arachidonic acid secretionGO:0504829.3BDKRB2, ACE
5blood coagulation, intrinsic pathwayGO:0075979.3KNG1, SERPING1, F12
6blood circulationGO:0080159.3BDKRB2, SERPING1
7regulation of vasoconstrictionGO:0192299.2BDKRB2, ACE
8vasodilationGO:0423119.2KNG1, BDKRB2
9smooth muscle contractionGO:0069399.2BDKRB2, KNG1
10blood coagulationGO:0075968.8F12, SERPING1, KNG1

Molecular functions related to Angioedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:0082379.1XPNPEP2, ACE
2protein bindingGO:0055157.3BDKRB2, KNG1, ACE, SERPING1, F12, C1S

Products for genes affiliated with Angioedema

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angioedema

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet