MCID: ANG041
MIFTS: 55

Angioedema, Hereditary, Types I and Ii malady

Categories: Genetic diseases, Rare diseases, Bone diseases, Immune diseases, Skin diseases

Aliases & Classifications for Angioedema, Hereditary, Types I and Ii

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 24GeneTests, 25Genetics Home Reference, 26GTR, 30ICD10 via Orphanet, 36MedGen, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Angioedema, Hereditary, Types I and Ii:

Name: Angioedema, Hereditary, Types I and Ii 51 12
Hereditary Angioneurotic Edema 11 47 24 25 53 69 26
Hereditary Angioedema 11 47 24 25 53 69 13
Hane 11 47 25 69
Hae 47 25 53 69
C1 Esterase Inhibitor Deficiency 24 25 69
Hereditary Angioedema, Type I 24 26
Hereditary Angioedema Type 1 47 53
Angioedemas, Hereditary 38 67
Angioedema, Hereditary 47 49
Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor 67
Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor 67
Hereditary Non Histamine-Induced Angioedema 53
 
Hereditary Bradykinine-Induced Angioedema 53
Hereditary Angioneurotic Edema Type 1 53
Hereditary Angioneurotic Edema Type 2 53
Hereditary Angioedema Types I and Ii 67
Deficiency of C1 Esterase Inhibitor 47
Angioedema, Hereditary, Type I 51
Hereditary Angioedema Type 2 53
Familial Angioneurotic Edema 53
C1 Inhibitor Deficiency 25
Hae-Ii 53
Hae 2 53
Hae-I 53

Characteristics:

Orphanet epidemiological data:

53
hereditary angioneurotic edema:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000 (Europe),1-9/100000 (Denmark),1-9/100000 (Norway),1-9/100000 (Spain); Age of onset: All ages
hereditary angioedema type 1:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000 (Italy); Age of onset: All ages
hereditary angioneurotic edema type 2:
Inheritance: Autosomal dominant; Age of onset: All ages

HPO:

63
angioedema, hereditary, types i and ii:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM51 106100
Disease Ontology11 DOID:14735
MeSH38 D054179
NCIt44 C84758
SNOMED-CT61 82966003
ICD10 via Orphanet30 D84.1
UMLS via Orphanet68 C0398776, C1862892, C0398775 C2717906, more
MESH via Orphanet39 C538577

Summaries for Angioedema, Hereditary, Types I and Ii

About this section
OMIM:51 Hereditary angioedema (HAE) is an autosomal dominant disorder characterized by episodic local subcutaneous edema and... (106100) more...

MalaCards based summary: Angioedema, Hereditary, Types I and Ii, also known as hereditary angioneurotic edema, is related to systemic lupus erythematosus and angioedema, hereditary, type iii, and has symptoms including edema, urticaria and ascites. An important gene associated with Angioedema, Hereditary, Types I and Ii is SERPING1 (Serpin Family G Member 1), and among its related pathways are Cell adhesion_Plasmin signaling and MSP-RON Signaling. Affiliated tissues include skin and bone.

Genetics Home Reference:25 Hereditary angioedema is a disorder characterized by recurrent episodes of severe swelling (angioedema). The most common areas of the body to develop swelling are the limbs, face, intestinal tract, and airway. Minor trauma or stress may trigger an attack, but swelling often occurs without a known trigger. Episodes involving the intestinal tract cause severe abdominal pain, nausea, and vomiting. Swelling in the airway can restrict breathing and lead to life-threatening obstruction of the airway. About one-third of people with this condition develop a non-itchy rash called erythema marginatum during an attack.

CDC:2 CDC's Health Alert Network (HAN) is CDC's primary method of sharing cleared information about urgent public health incidents with public information officers; federal, state, territorial, and local public health practitioners; clinicians; and public health laboratories.

UniProtKB/Swiss-Prot:69 Hereditary angioedema: An autosomal dominant disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. Hereditary angioedema due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In hereditary angioedema type 1, serum levels of C1 esterase inhibitor are decreased, while in type 2, the levels are normal or elevated, but the protein is non-functional.

Wikipedia:70 Hereditary angioedema (HAE) is a rare, autosomal dominantly inherited blood disorder that causes... more...

Related Diseases for Angioedema, Hereditary, Types I and Ii

About this section

Diseases in the Angioedema family:

Angioedema, Hereditary, Type Iii angioedema, hereditary, types i and ii
Acquired Angioedema Acquired Angioedema Type 1
Acquired Angioedema Type 2

Diseases related to Angioedema, Hereditary, Types I and Ii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus28.2C1R, C1S, C4B, CR1
2angioedema, hereditary, type iii11.9
3c1 inhibitor deficiency11.3
4angioedema11.1
5frasier syndrome10.9
6acquired hypoprothrombinemia10.4C1S, SERPING1
7inflammatory breast carcinoma10.3KNG1, SERPING1
8laryngitis10.2
9meibomian cyst10.1F12, KLK4
10atrophic rhinitis10.1BDKRB2, KNG1
11meesmann corneal dystrophy10.1C1R, C1S
12pancreatitis10.0
13mechanical lagophthalmos10.0C4B, SERPING1
14broad ligament malignant neoplasm10.0KLK4, KNG1
15chronic closed-angle glaucoma10.0KLK4, KNG1, SERPING1
16acute pancreatitis9.9
17lupus erythematosus9.9
18acquired angioedema9.9
19urticaria9.9
20endotheliitis9.9
21hemolytic uremic syndrome, atypical 39.8C4B, CR1
22voyeurism9.8KLK4, KLKB1, KNG1
23autosomal thrombocytopenia with normal platelets9.8C1R, C1S, C4B
24celiac disease9.8
25arthritis9.8
26atherosclerosis9.8
27compartment syndrome9.8
28lung cancer9.6
29hepatocellular carcinoma9.6
30breast cancer9.6
31pancreatitis, hereditary9.6
32psoriatic arthritis9.6
33membranous nephropathy9.6
34fabry disease9.6
35adult respiratory distress syndrome9.6
36glomerulonephritis9.6
37cutaneous lupus erythematosus9.6
38purpura fulminans9.6
39allergic urticaria9.6
40hypoparathyroidism9.6
41bacteriuria9.6
42vaginitis9.6
43cervicitis9.6
44periarthritis9.6
45food allergy9.6
46ischemia9.6
47purpura9.6
48cerebritis9.6
49aortitis9.6
50thyroiditis9.6

Graphical network of the top 20 diseases related to Angioedema, Hereditary, Types I and Ii:



Diseases related to angioedema, hereditary, types i and ii

Symptoms for Angioedema, Hereditary, Types I and Ii

About this section

Symptoms by clinical synopsis from OMIM:

106100

Clinical features from OMIM:

106100

Human phenotypes related to Angioedema, Hereditary, Types I and Ii:

 63 53 (show all 17)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 edema63 53 hallmark (90%) Very frequent (99-80%) HP:0000969
2 urticaria63 hallmark (90%) HP:0001025
3 ascites63 53 occasional (7.5%) Occasional (29-5%) HP:0001541
4 abdominal pain63 53 occasional (7.5%) Occasional (29-5%) HP:0002027
5 intestinal obstruction63 53 occasional (7.5%) Occasional (29-5%) HP:0005214
6 immunologic hypersensitivity63 occasional (7.5%) HP:0100326
7 abnormality of the larynx63 HP:0001600
8 vomiting63 HP:0002013
9 diarrhea63 HP:0002014
10 autoimmunity63 HP:0002960
11 peripheral axonal neuropathy63 HP:0003477
12 intestinal edema63 53 Occasional (29-5%) HP:0005225
13 erythema63 HP:0010783
14 pharyngeal edema63 HP:0011855
15 laryngeal edema63 53 Occasional (29-5%) HP:0012027
16 angioedema63 53 Very frequent (99-80%) HP:0100665
17 facial edema53 Occasional (29-5%)

UMLS symptoms related to Angioedema, Hereditary, Types I and Ii:


periorbital edema, welts, edema of mouth, lip swelling, mouth swelling, oropharyngeal swelling

Drugs & Therapeutics for Angioedema, Hereditary, Types I and Ii

About this section

Drugs for Angioedema, Hereditary, Types I and Ii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 62)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IcatibantapprovedPhase 4, Phase 3, Phase 117138614-30-9, 130308-48-471364
Synonyms:
(2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
(2s)-2-({[(3as,7as)-1-({2-[(2s)-2-{[(2s)-2-({[({(4r)-1-[(1-{2-({(2r)-2-amino-5-[(diaminomethylidene)amino]pentanoyl}amino)-5-[(diaminomethylidene)amino]pentanoyl}pyrrolidin-2-yl)carbonyl]-4-hydroxypyrrolidin-2-yl}carbonyl)amino]acetyl}amino)-3-(thiophen-2-yl)propanoyl]amino}-3-hydroxypropanoyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}carbonyl)octahydro-1h-indol-2-yl]carbonyl}amino)-5-[(diaminomethylidene)amino]pentanoic acid(non-preferred name)
130308-48-4
138614-30-9 (acetate)
13996-86-6
153322-84-0
AC1L2G0Q
AC1Q5QRX
AR-1A3141
C59H89N19O13S
CHEBI:163731
CHEMBL411169
 
CID71364
D-Arg(Hyp(3)-Thi(5)-D-Tic(7)-Oic(8))BK
DB06196
Firazyr
HOE 140
HOE140
Hoe-140
Icatibant
Icatibant [INN]
JE049
KST-1A1301
LS-172762
WIN 65365
WIN-65365
2
Omalizumabapproved, investigationalPhase 4143242138-07-4
Synonyms:
242138-07-4
D05251
Ig gamma-1 chain C region
Omalizumab
 
Omalizumab (USAN/INN)
Omalizumab (genetical recombination)
Omalizumab (genetical recombination) (JAN)
Xolair
Xolair (TN)
3Vasodilator AgentsPhase 4, Phase 3, Phase 13438
4Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 122776
5KininogensPhase 4, Phase 3, Phase 150
6Complement C1 Inhibitor ProteinPhase 4, Phase 3, Phase 2, Phase 150
7Complement C1sPhase 4, Phase 3, Phase 2, Phase 131
8AnalgesicsPhase 4, Phase 3, Phase 111287
9ImmunoglobulinsPhase 4, Phase 16045
10AntibodiesPhase 4, Phase 16045
11Immunosuppressive AgentsPhase 4, Phase 3, Phase 2, Phase 112770
12Complement C1 Inactivator ProteinsPhase 4, Phase 3, Phase 2, Phase 149
13Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 3, Phase 14295
14Complement System ProteinsPhase 4, Phase 3, Phase 2, Phase 1228
15Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 110355
16Antirheumatic AgentsPhase 4, Phase 3, Phase 110627
17
BradykininPhase 4, Phase 3, Phase 15058-82-2439201
Synonyms:
Callidin I
Kallidin 9
 
Kallidin I
L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-Arginine
L-Bradykinin
18Complement Inactivating AgentsPhase 4, Phase 3, Phase 2, Phase 196
19Bradykinin Receptor AntagonistsPhase 4, Phase 3, Phase 119
20Analgesics, Non-NarcoticPhase 4, Phase 3, Phase 16260
21Bradykinin B2 Receptor AntagonistsPhase 4, Phase 3, Phase 119
22
LactitolPhase 4332585-86-43871
Synonyms:
4-O-b-D-Galactopyranosyl-D-glucitol, 9CI
E966
Emportal
 
Floralac
Importal
Oponaf
Portolac
23Respiratory System AgentsPhase 44818
24Anti-Asthmatic AgentsPhase 43369
25Anti-Allergic AgentsPhase 41490
26histidineNutraceuticalPhase 442
27
Tranexamic AcidapprovedPhase 32571197-18-85526
Synonyms:
08455_FLUKA
1197-17-7
1197-18-8
1ceb
3-14-00-00868 (Beilstein Handbook Reference)
4-(Aminomethyl)-Cyclohexanecarboxylic Acid
4-(Aminomethyl)cyclohexanecarboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
857653_ALDRICH
A0236
AB00052260
AB1003647
AC-4687
AC1L1KJH
AC1Q50F3
AC1Q546D
AC1Q5U04
ALBB-006013
AMCA
AMCHA
AMH
AR-1F6595
Acide tranexamique
Acide tranexamique [INN-French]
Acido tranexamico
Acido tranexamico [INN-Spanish]
Acidum tranexamicum
Acidum tranexamicum [INN-Latin]
Amikapron
Amstat
Anvitoff
BAY 3517
BPBio1_000069
BRN 2207452
BSPBio_000061
BSPBio_002837
CAS-1197-18-8
CHEBI:48669
CHEMBL292500
CHEMBL877
CID5526
CL 65336
CL-65336
Carxamin
Cyclocapron
Cyklokapron
Cyklokapron (TN)
D01136
DB00302
DV 79
DV-79
DV79
DivK1c_000655
EINECS 214-818-2
Emorhalt
Exacyl
Frenolyse
HMS1568D03
HMS1921F08
HMS2092P03
HMS502A17
Hexapromin
Hexatron
I04-0993
IDI1_000655
KABI 2161
KBio1_000655
KBio2_001871
KBio2_004439
KBio2_007007
KBio3_002337
KBioGR_000511
 
KBioSS_001871
LS-56611
LS-56612
LT00159441
Mastop
MolPort-001-792-390
MolPort-002-512-008
NCGC00016569-01
NCGC00016569-02
NCGC00016569-03
NCGC00094944-01
NCGC00094944-02
NINDS_000655
NSC 291305
NSC291305
Oprea1_786414
Prestwick0_000171
Prestwick1_000171
Prestwick2_000171
Prestwick3_000171
Prestwick_476
RP 18,429
Rikavarin
Rikavarin (TN)
Rikavarin-S
SPBio_000689
SPBio_001982
SPECTRUM1502026
STK503668
STOCK1N-16183
Spectrum2_000655
Spectrum3_001189
Spectrum4_000046
Spectrum5_001258
Spectrum_001391
Spiramin
Tamcha
Tranex
Tranexamate
Tranexamic acid (JP15/USAN/INN)
Tranexamic acid [USAN:INN:BAN:JAN]
Tranexamic acid cis-form
Tranexamsaeure
Tranexan
Tranexmic acid
Tranhexamic acid
Trans AMCHA
Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid
Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid
Trans-p-(Aminomethyl)cyclohexanecarboxylic
Transamin
Transamin (TN)
Transamlon
Trasamlon
UNII-6T84R30KC1
Ugurol
WLN: L6TJ AVQ D1Z -T
cis-4-(Aminomethyl)cyclohexanecarboxylic acid
cis-4-Aminomethylcyclohexane-1-carboxylic acid
cis-AMCHA
t-AMCHA
tranexamic acid
tranexmic acid
trans-1-Aminomethylcyclohexane-4-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-carboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester
trans-4-Aminomethylcyclohexane-1-carboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-Amcha
trans-Tranexamic acid
trans-p-(Aminomethyl)cyclohexanecarboxylic acid
28
BenzocaineapprovedPhase 318921994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthone
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Bensokain
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Caswell No. 430A
Chloraseptic
D001566
D00552
DB01086
Dermoplast
Diet Ayds
DivK1c_000932
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
 
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Formate, Benzocaine
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Hurricaine
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Keloform
LS-35847
MLS001331704
MLS002153970
Methanesulfonate, Benzocaine
MolPort-000-871-526
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Norcain
Norcaine
Norcainum
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orthesin
Otocain
Outgro
Parathesin
Parathesin (TN)
Parathesine
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Topcaine
UNII-U3RSY48JW5
WLN: ZR DVO2
ZINC12358719
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
29tannic acidapproved, NutraceuticalPhase 31892
30KallikreinsPhase 3, Phase 2, Phase 125
31Plasma KallikreinPhase 3, Phase 2, Phase 16
32HemostaticsPhase 31359
33Fibrinolytic AgentsPhase 32317
34Antifibrinolytic AgentsPhase 3459
35Pharmaceutical SolutionsPhase 3, Phase 27793
36CoagulantsPhase 31428
37PassionflowerNutraceuticalPhase 316
38
DanazolapprovedPhase 21617230-88-528417
Synonyms:
(17a)-Pregna-2,4-dien-20-yno[2,3-D]isoxazol-17-ol
(1R,3aS,3bR,10aR,10bS,12aS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol
(1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-trien-17-ol
1-Ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol
1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-Cyclopenta[7,8]phenanthro[3,2-D]isoxazol-1-ol
17 alpha-Pregna-2,4-dien-20-yno[2,3-D] isoxazol-17 beta-ol
17-alpha-2,4-Pregnadien-20-yno(2,3-d)isoxazol-17-ol
17-alpha-Pregn-4-en-20-yno(2,3-d)isoxazol-17-ol
17-alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol
17.Alpha.-Pregna-2, {4-dien-20-yno[2,3-d]isoxazol-17-ol}
17230-88-5
17a-Pregna-2,4-dien-20-yne-[2,3-D]isoxazole-17b-ol
17a-Pregna-2,4-dien-20-yno[2,3-D]isoxazol-17-ol
17alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol
1H-Cyclopenta[7,8]phenanthro[3,2-D]isoxazole- pregna-2,4-dien-20-yno[2,3-D]isoxazol-17-ol deriv.
AC-6836
AC1L1FAD
AC1Q282K
AC1Q29FD
Alphapharm Brand of Danazol
Antigen Brand of Danazol
BPBio1_000100
BRD-K48970916-001-03-0
BSPBio_000090
Bonzol
CCRIS 6747
CHEBI:4315
CHEMBL1479
CID28417
CPD000058321
Chronogyn
Cyclomen
D00289
D003613
DB01406
Danatrol
Danazant
Danazol (JAN/USP/INN)
Danazol [USAN:BAN:INN:JAN]
Danazol-ratiopharm
Danazole
Danazolum
Danazolum [INN-Latin]
Danocrine
 
Danocrine (TN)
Danogen
Danokrin
Danol
Danoval
Danovaol
Danzol
EINECS 241-270-1
HMS1568E12
HMS2090A22
Kendrick Brand of Danazol
LS-118524
Ladogal
MLS001066617
MLS001306473
MolPort-002-513-504
NCGC00164400-01
NCGC00179665-01
NSC 270916
NSC270916
Norciden
Panacrine
Prestwick0_000105
Prestwick1_000105
Prestwick2_000105
Prestwick3_000105
Prestwick_150
SAM002564203
SMR000058321
SPBio_002029
STOCK1N-23495
Sanofi Brand of Danazol
Sanofi Synthelabo Brand of Danazol
Sanofi Winthrop Brand of Danazol
UNII-N29QWW3BUO
WIN 17,757
WIN 17757
WIN-17757
Win 17, 757
Winobanin
ZINC03881958
[1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol
anatrol
danazol
ratiopharm Brand of Danazol
39HormonesPhase 2, Phase 113979
40Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 2, Phase 112767
41Hormone AntagonistsPhase 2, Phase 112778
42EstrogensPhase 22470
43Estrogen AntagonistsPhase 21315
44Estrogen Receptor ModulatorsPhase 2630
45
Omeprazoleapproved, investigational, vet_approvedPhase 133773590-58-64594
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(S)-(-)-Omeprazole
(S)-Omeprazole
119141-89-8
131959-78-9
172964-80-6
2,3,5-Trimethylpyridine/Omeprazole
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Aulcer
Axagon
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CPD000058847
Ceprandal
D00455
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Erbolin
Esomeprazole
Esomperazole
Esopral
Exter
Gasec
Gastrimut
Gastroloc
Gibancer
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
I06-0705
IDI1_032523
Indurgan
Inhibitron
Inhipump
LS-7629
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Mepral
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
Mopral
Morecon
NCGC00016925-01
 
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMP
OMZ
Ocid
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole
Omeprazole (JAN/USP/INN)
Omeprazole Pellets
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Prazentol
Prazidec
Prazolit
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
TL8005099
Tedec Ulceral
UNII-KG60484QX9
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
omeprazole
46
Midazolamapproved, illicitPhase 168459467-70-84192
Synonyms:
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
59467-70-8
8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride
8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine
8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine
AC-18749
AC1L1HMA
BIDD:GT0647
BRN 0625572
Buccolam
C07524
C18H13ClFN3
CHEMBL655
CID4192
D00550
DB00683
DEA No. 2884
Dazolam
Dea No. 2884
 
Dormicum
Dormicum (TN)
EINECS 261-774-5
LS-77780
Midanium
Midazolam
Midazolam (JAN/INN)
Midazolam Base
Midazolam Hcl
Midazolam [INN:BAN:JAN]
Midazolamum
Midazolamum [INN-Latin]
Midosed
MolPort-003-849-219
NCGC00168254-01
Ro 21-3981
TL8003787
UC429_SIGMA
UNII-R60L0SM5BC
Versed
ZINC00001732
midazolam
nchembio747-comp32
47
TolbutamideapprovedPhase 12264-77-75505
Synonyms:
1-Butyl-3-(4-methylphenylsulfonyl)urea
1-Butyl-3-(P-methylphenylsulfonyl)urea
1-Butyl-3-(P-tolylsulfonyl)urea
1-Butyl-3-(p-methylphenylsulfonyl)urea
1-Butyl-3-(p-tolylsulfonyl)urea
1-Butyl-3-(para-tolylsulfonyl) urea
1-Butyl-3-tosylurea
1-P-Toluenesulfonyl-3-butylurea
1-butyl-3-(4-methylphenyl)sulfonylurea
1-p-Toluenesulfonyl-3-butylurea
100735-34-0
3-(P-Tolyl-4-sulfonyl)-1-butylurea
3-(p-Tolyl-4-sulfonyl)-1-butylurea
3-(p-tolylsulfonyl)-1-butylurea
3-[p-Tolyl-4-sulfonyl]-1-butylurea
46968_FLUKA
46968_RIEDEL
64-77-7
AB00052110
AB1004876
AC-12490
AC1L1KHP
AC1Q2X3T
Aglicid
Apo-Tolbutamide
Apotex Brand of Tolbutamide
Arcosal
Arkozal
Artosin
Artozin
Aventis Brand of Tolbutamide
BIDD:PXR0179
BIM-0051121.0001
BPBio1_000131
BRD-K85119730-001-06-5
BRN 1984428
BSPBio_000119
BSPBio_001507
BSPBio_002078
Beglucin
Berlin Chemie Brand of Tolbutamide
Berlin-Chemie Brand of Tolbutamide
Bio1_000206
Bio1_000695
Bio1_001184
Bio2_000227
Bio2_000707
Butamid
Butamide
Butamide Brand of Tolbutamide
Butamidum
C07148
C12H18N2O3S
CAS-64-77-7
CBiol_001920
CCRIS 592
CHEBI:27999
CHEMBL782
CID5505
CPD000058363
D 860
D00380
D014044
DB01124
Diaben
Diabesan
Diabetamid
Diabetol
Diabuton
Diasulfon
Diaval
Dirastan
DivK1c_000341
Dolipol
Drabet
EINECS 200-594-3
EU-0101154
Glyconon
HLS 831
HMS1361L09
HMS1568F21
HMS1791L09
HMS1989L09
HMS2089C17
HMS2092M21
HMS501B03
HSDB 3393
Hoechst Brand of Tolbutamide
IDI1_000341
IDI1_033977
Ipoglicone
KBio1_000341
KBio2_000227
KBio2_000927
KBio2_002275
KBio2_002795
KBio2_003495
KBio2_004843
KBio2_005363
KBio2_006063
KBio2_007411
KBio3_000453
KBio3_000454
KBio3_001578
KBio3_002755
KBioGR_000227
KBioGR_000795
KBioGR_002275
KBioSS_000227
KBioSS_000927
KBioSS_002276
 
LS-278
Lopac-T-0891
Lopac0_001154
MLS000028399
MLS001148399
MLS002152944
Mobenol
MolPort-001-783-540
N-(4-Methylbenzenesulfonyl)-N'-butylurea
N-(4-Methylbenzenesulfonyl)-n'-butylurea
N-(4-Methylphenylsulfonyl)-N'-butylurea
N-(4-Methylphenylsulfonyl)-n'-butylurea
N-(P-Methylbenzenesulfonyl)-n'-butylurea
N-(Sulfonyl-P-methylbenzene)-n'-N-butylurea
N-(p-Tolylsulfonyl)-N'-butylcarbamide
N-(p-tolylsulfonyl)-N'-n-butylurea
N-4-(Methylbenzolsulfonyl)-n-butylurea
N-4-Methylbenzolsulfonyl-N-butylurea
N-Butyl-N'-(4-methylphenylsulfonyl)urea
N-Butyl-N'-(p-tolylsulfonyl)urea
N-Butyl-N'-p-toluenesulfonylurea
N-Butyl-N'-toluene-p-sulfonylurea
N-Butyl-n'-(4-methylphenylsulfonyl)urea
N-Butyl-n'-P-toluenesulfonylurea
N-N-Butyl-n'-tosylurea
N-n-Butyl-N'-tosylurea
NCGC00015999-01
NCGC00015999-02
NCGC00015999-03
NCGC00015999-07
NCGC00015999-14
NCGC00022721-03
NCGC00022721-04
NCGC00022721-05
NCGC00022721-06
NCGC00022721-07
NCGC00022721-08
NCGC00022721-09
NCGC00022721-10
NCI-C01763
NCIOpen2_009592
NINDS_000341
NSC 23813
NSC23813
Novo-Butamide
Orabet
Oralin
Oramide
Orezan
Orinase
Orinase (TN)
Orinase (tn)
Orinase Diagnostic
Orinaz
Oterben
Pfizer Brand of Tolbutamide
Pramidex
Prestwick0_000190
Prestwick1_000190
Prestwick2_000190
Prestwick3_000190
Prestwick_471
R.A.N. Brand of Tolbutamide
Rastinon
Restinon
SAM002554936
SMR000058363
SPBio_001000
SPBio_002040
SPECTRUM1500581
Sk-tolbutamide
Spectrum2_001210
Spectrum3_000599
Spectrum4_000358
Spectrum5_001272
Spectrum_000447
T 0891
T0891_FLUKA
T0891_SIGMA
TL8000121
TOLBUTAMIDE USP
Tarasina
Tol-Tab
Tolbet
Tolbusal
Tolbutamid
Tolbutamid R.A.N.
Tolbutamida
Tolbutamida [INN-Spanish]
Tolbutamide
Tolbutamide (JP15/USP/INN)
Tolbutamide Aventis Brand
Tolbutamide Butamide Brand
Tolbutamide Hoechst Brand
Tolbutamide Pfizer Brand
Tolbutamide [INN:BAN:JAN]
Tolbutamidum
Tolbutamidum [INN-Latin]
Tolbutone
Toluina
Tolumid
Toluvan
Tolylsulfonylbutylurea
U 2043
UNII-982XCM1FOI
Valdecasas Brand of Tolbutamide
WLN: 4MVMSWR D1
Willbutamide
Yamanouchi Brand of Tolbutamide
ZINC01530703
cMAP_000008
tolbutamide
toluran
48
Oxandroloneapproved, investigationalPhase 11553-39-45878
Synonyms:
(1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one
(4aS,4bS,6aS,7S,9aS,9bR,11aS)-7-hydroxy-4a,6a,7-trimethyltetradecahydroindeno[4,5-h]isochromen-2(1H)-one
17-beta-hydroxy-17-methyl-2-oxa-androstan-3-one
17-beta-hydroxy-17-methyl-2-oxa-androstan-3-one (9CI)
17beta-Hydroxy-17-methyl-2-oxa-5alpha-androstan-3-one
17beta-Hydroxy-17alpha-methyl-2-oxa-5alpha-androstan-3-one
2-Oxa-5alpha-androstan-3-one, 17beta-hydroxy-17-methyl- (8CI)
2-Oxaandrostan-3-one, 17-hydroxy-17-methyl-, (5-alpha,17-beta)- (9CI)
53-39-4
8075 C. B
8075 C. B.
8075 C.B
8075 C.B.
8075 CB
AC-14975
AC1L1LBY
Ambap53-39-4
Anavar
C07346
C19H30O3
CHEBI:7820
CHEMBL1200436
CID5878
D00462
DB00621
Dodecahydro-3-hydroxy-6-(hydroxy-methyl)-3,3a,6-trimethyl-1H-benz(e)indene-7-acetic acid delta-lactone
EINECS 200-172-9
 
HSDB 3373
LS-98540
Lonavar
MolPort-003-986-935
NSC 67068
OXANDROLONE
Ossandrolone
Ossandrolone [DCIT]
Oxandrin
Oxandrin (TN)
Oxandrin, Anavar, Oxandrolone
Oxandrolon
Oxandrolona
Oxandrolona [INN-Spanish]
Oxandrolone
Oxandrolone (JAN/USP/INN)
Oxandrolone [USAN:INN:BAN:JAN]
Oxandrolonum
Oxandrolonum [INN-Latin]
Protivar
Provitar
S1753_Selleck
SC 11585
SC-11585
TL8003512
UNII-7H6TM3CT4L
Vasorome
ZINC03813047
49
DextromethorphanapprovedPhase 1129125-71-35360696, 5362449
Synonyms:
( )-3-Methoxy-N-methylmorphinon
( )-cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4alpha-iminoethanophenanthren
(+)-3-Methoxy-17-methylmorphinan
(+)-dextromethorphan
(-)-3-Methoxy-N-methylmorphinan
(9alpha,13alpha,14alpha)-17-methyl-3-(methyloxy)morphinan
125-69-9 (hydrobromide)
125-70-2
125-71-3
18046-32-7
18609-21-7 (hydrochloride)
3-Methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan
3-Methoxy-17-methylmorphinan
32062-10-5
4-21-00-01367 (Beilstein Handbook Reference)
6700-34-1 (hydrobromide, mono-hydrate)
9alpha,13alpha,14alpha-Morphinan, 3-methoxy-17-methyl- (8CI)
AC-13098
AC1L1EYT
Albutussin
Antussan
BA 2666
BPBio1_000503
BRD-K33211335-337-03-7
BRN 0088549
BSPBio_000457
Balminil DM
Balminil DM Children
Bayer Select Flu Relief
Bayer Select Head & Chest Cold
Bayer Select Night Time Cold
Benylin Adult Formula Cough Suppressant
Benylin DM
Benylin DM (TN)
Benylin DM 12 Hour
Benylin DM for Children
Benylin DM for Children 12 Hour
Benylin Pediatric Cough Suppressant
C06947
CHEBI:128891
CHEBI:4470
CHEBI:580686
CHEMBL22207
CHEMBL52440
CID3008
CID5360696
CID5362449
Calmylin #1
Canfodion
Cerose-DM
Chloraseptic DM
Contac Day & Night Cold/Flu Day Caplets
Contac Jr. Non-drowsy Formula
Contac Nighttime Cold Medicine
Contac Severe Cold Formula Maximum Strength
Contac Severe Cold Formula Non-Drowsy
Coricidin Syrup
Cosylan
Cough-X
Creo-Terpin
D-Methorphan
D-Methorphan Hydrobromide
D-methorphan
D03742
DB00514
DEA No. 9210
DM
DXM
Delsym
Delsym Cough Formula
Delta-Methorphan
Demorphan
Demorphan Hydrobromide
Demorphan hydrobromide
Demorphine
Destrometerfano
Destrometerfano [DCIT]
Destrometerfano [Dcit]
Dex
Dextromethorfan
Dextromethorfan [Czech]
Dextromethorphan
Dextromethorphan (USP)
Dextromethorphan Bromhydrate
Dextromethorphan Bromide
Dextromethorphan [USP:INN:BAN]
Dextromethorphan hydrobromide OROS Tablets
Dextromethorphan hydrobromide [BAN:JAN]
Dextromethorphan hydrobromide monohydrate
Dextromethorphane
Dextromethorphane [INN-French]
Dextromethorphanum
Dextromethorphanum [INN-Latin]
Dextrometorfano
Dextrometorfano [INN-Spanish]
Dextrometorphan
Dextromorphan
Dextrométhorphane
Dexyromethorphan
Diabe-Tuss DM Syrup
 
Dimacol
Dimetapp DM
Dormetan
Dormethan
Drixoral Cough
Drixoral Cough & Congestion
Drixoral Cough & Sore Throat
EINECS 204-751-7
EINECS 204-752-2
Endotussin-NN
Endotussin-NN Pediatric
HMS2090C08
HSDB 3056
Hihustan M.
Hold
Hold DM
Koffex DM
L-Methorphan
LS-91837
LS-91838
Levomethorphan
Levomethorphan [BAN:DCF:INN]
Levomethorphan [Ban:Dcf:Inn]
Levomethorphan [INN:BAN:DCF]
Levomethorphane
Levomethorphane [INN-French]
Levomethorphanum
Levomethorphanum [INN-Latin]
Levometorfano
Levometorfano [INN-Spanish]
Lopac-D-2531
Lopac0_000337
MLS000758303
Medicon
Methorate
Methorate Hydrobromide
Methorphan
Metrorat
MolPort-003-940-943
MolPort-004-285-957
Morphinan, 3-methoxy-17-methyl-, (9-alpha,13-alpha,14-alpha)- (9CI)
NCGC00015333-01
NCGC00015333-02
NCGC00015333-04
NCGC00162126-01
Naldecon-DX
Novahistex DM
Novahistine DM
Ornex Severe Cold Formula
Orthoxicol
PediaCare 1
PediaCare Cough-Cold Formula
Pertussin CS Children's Strength
Pertussin DM Extra Strength
Prestwick0_000359
Prestwick1_000359
Prestwick2_000359
Prestwick3_000359
Prestwick_686
RACEMETHORPHAN
Robitussin CF
Robitussin Cold & Cough
Robitussin Cough Calmers
Robitussin DM
Robitussin Maximum Strength Cough
Robitussin Maximum Strength Cough Suppressant
Robitussin Pediatric
Robitussin Pediatric Cough
Robitussin Pediatric Cough & Cold
Robitussin Pediatric Cough Suppressant
Robitussin Pediatric Night Relief
Romilar
Rondec dm
Ru-Tuss Expectorant
SPBio_002378
St. Joseph Cough Syrup
Sucrets 4 Hour Cough Suppressant
Sudafed Cough Syrup
Triaminic
Triaminic DM Long Lasting for Children
Trind-DM
Trocal
Tusilan
Tussade
Tussar DM
Tussi-Organidin
Tussi-Organidin DM NR
Tussi-Organidin DM-S NR
Tylenol Cold No Drowsiness
Tylenol Cold and Flu Multi-Symptom
Tylenol Cold and Flu No Drowsiness
Tylenol Cough + Decongestant Liquid
Tylenol Cough Liquid
Tylenol Flu No Drowsiness Gelcaps
UNII-7355X3ROTS
Vicks 44 Cough Relief
Viro-Med
d-Methorphan
delta-Methorphan
dextromethorphan
l-Methorphan
50Adrenergic AntagonistsPhase 11535

Interventional clinical trials:

(show top 50)    (show all 77)
idNameStatusNCT IDPhase
1A Call Center During HAE Attacks (SOS HAE)CompletedNCT01679912Phase 4
2Efficacy, Safety and Tolerability of Icatibant for the Treatment of HAECompletedNCT01457430Phase 4
3A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZECompletedNCT00914966Phase 4
4Postmarketing Immunogenicity Study in HAE Subjects Treated With BerinertCompletedNCT01467947Phase 4
5Treatment of Idiopathic Angioedema With Xolair as Add-on TherapyNot yet recruitingNCT02966314Phase 4
6C1-INH Compared to Placebo at the Time of Prodromal Symptoms for Hereditary Angioedema (HAE) ExacerbationWithdrawnNCT01151735Phase 4
7A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary AngioedemaCompletedNCT01912456Phase 3
8Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) AttacksCompletedNCT00438815Phase 3
9A Study of Icatibant in Patients With Acute Attacks of Hereditary Angioedema (FAST-3)CompletedNCT00912093Phase 3
10Safety and Efficacy Study of Repeated Doses of DX-88 (Ecallantide) to Treat Attacks of Hereditary Angioedema (HAE)CompletedNCT00456508Phase 3
11Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) AttacksCompletedNCT00462709Phase 3
12Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE)CompletedNCT00457015Phase 3
13Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary AngioedemaCompletedNCT00225147Phase 2, Phase 3
14Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary AngioedemaCompletedNCT00262301Phase 3
15C1 Esterase Inhibitor in Hereditary Angioedema (HAE)(Extension Study)CompletedNCT00292981Phase 3
16C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) AttacksCompletedNCT01005888Phase 3
17Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) AttacksCompletedNCT00168103Phase 2, Phase 3
18Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema (HAE)CompletedNCT00500656Phase 3
19Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE)CompletedNCT00262080Phase 3
20Berinert P Study of Subcutaneous Versus Intravenous AdministrationCompletedNCT00748202Phase 3
21Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary AngioedemaCompletedNCT00097695Phase 3
22EASSI - Evaluation of the Safety of Self-Administration With IcatibantCompletedNCT00997204Phase 3
23Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary AngioedemaCompletedNCT00262288Phase 2, Phase 3
2412-Week Safety and Efficacy Study of BCX4161 as an Oral Prophylaxis Against HAE AttacksCompletedNCT02303626Phase 2, Phase 3
25C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) AttacksCompletedNCT00289211Phase 3
26Efficacy, Safety and Immunogenicity Study of Recombinant Human C1 Inhibitor for the Treatment of Acute HAE AttacksCompletedNCT01188564Phase 3
27C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) AngioedemaCompletedNCT00125151Phase 3
28C1-Esteraseremmer-N for the Treatment of Hereditary (and Acquired) AngioedemaCompletedNCT00125541Phase 2, Phase 3
29Study of C1 Inhibitor (Human) for the Prevention of Angioedema Attacks and Treatment of Breakthrough Attacks in Japanese Subjects With Hereditary Angioedema (HAE)RecruitingNCT02865720Phase 3
30A Pharmacokinetic, Tolerability and Safety Study of Icatibant in Children and Adolescents With Hereditary AngioedemaActive, not recruitingNCT01386658Phase 3
31Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary AngioedemaActive, not recruitingNCT02584959Phase 3
32Safety and Efficacy Study of CINRYZE for Prevention of Angioedema Attacks in Children Ages 6-11 With Hereditary AngioedemaActive, not recruitingNCT02052141Phase 3
33A Study to Evaluate the Long-term Clinical Safety and Efficacy of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary AngioedemaActive, not recruitingNCT02316353Phase 3
34Efficacy and Safety Study of DX-2930 to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAEActive, not recruitingNCT02586805Phase 3
35Long-term Safety and Efficacy Study of DX-2930 to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAEEnrolling by invitationNCT02741596Phase 3
36Open-label, Long-term Safety Study of Avoralstat in Subjects With Hereditary AngioedemaTerminatedNCT02670720Phase 3
37Study to Evaluate Ecallantide in Paediatric Patients With Acute Attacks of Hereditary AngioedemaWithdrawnNCT01253382Phase 2, Phase 3
38CINRYZE for the Treatment of Hereditary Angioedema Attacks in Children Under the Age of 12CompletedNCT01095510Phase 2
39Safety and Efficacy of Oral BCX4161 as a Prophylactic Treatment for HAECompletedNCT01984788Phase 2
40A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CINRYZE AdministrationCompletedNCT01095497Phase 2
41Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary AngioedemaCompletedNCT00261053Phase 2
42A Study to Evaluate the Safety and Pharmacology of Subcutaneous Administration of CINRYZE With Recombinant Human HyaluronidaseCompletedNCT01426763Phase 2
43EDEMA2: Evaluation of DX-88's Effect in Mitigating AngioedemaCompletedNCT01826916Phase 2
44A Phase 2 HAE Prophylaxis Study With Recombinant Human C1 InhibitorCompletedNCT02247739Phase 2
45A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous RouteCompletedNCT01576523Phase 1, Phase 2
46A Study of the Safety and Immunogenicity of Repeated rhC1INH AdministrationCompletedNCT00851409Phase 2
47Subcutaneous CINRYZE With Recombinant Human Hyaluronidase for Prevention of Angioedema AttacksCompletedNCT01756157Phase 2
48Kinetics, Efficacy and Safety of C1-Esteraseremmer-NCompletedNCT00119431Phase 2
49Efficacy and Safety Study to Evaluate Two Doses of Oral DMI-5207 in Adult Subjects With Diabetic Macular EdemaCompletedNCT02002403Phase 2
50A Study to Evaluate the Safety and Efficacy of HAE1 in Subjects With Moderate to Severe Allergic AsthmaCompletedNCT00406965Phase 2

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Genetic Tests for Angioedema, Hereditary, Types I and Ii

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Genetic tests related to Angioedema, Hereditary, Types I and Ii:

id Genetic test Affiliating Genes
1 Hereditary Angioneurotic Edema26
2 Hereditary Angioedema Type 126
3 Hereditary Angioedema24 SERPING1

Anatomical Context for Angioedema, Hereditary, Types I and Ii

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MalaCards organs/tissues related to Angioedema, Hereditary, Types I and Ii:

35
Skin, Bone

Animal Models for Angioedema, Hereditary, Types I and Ii or affiliated genes

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Publications for Angioedema, Hereditary, Types I and Ii

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Variations for Angioedema, Hereditary, Types I and Ii

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UniProtKB/Swiss-Prot genetic disease variations for Angioedema, Hereditary, Types I and Ii:

69 (show all 40)
id Symbol AA change Variation ID SNP ID
1SERPING1p.Gly429ArgVAR_007013
2SERPING1p.Val454GluVAR_007014rs121907949
3SERPING1p.Ala456GluVAR_007015
4SERPING1p.Ala458ThrVAR_007016rs121907947
5SERPING1p.Ala458ValVAR_007017
6SERPING1p.Ala465ValVAR_007018rs121907950
7SERPING1p.Arg466CysVAR_007019rs28940870
8SERPING1p.Arg466HisVAR_007020rs121907948
9SERPING1p.Arg466LeuVAR_007021rs121907948
10SERPING1p.Arg466SerVAR_007022rs28940870
11SERPING1p.Thr467ProVAR_007023
12SERPING1p.Val473MetVAR_007024
13SERPING1p.Phe477SerVAR_007026
14SERPING1p.Leu481ProVAR_007028
15SERPING1p.Leu481ArgVAR_007029
16SERPING1p.Pro489ArgVAR_007030
17SERPING1p.Pro498SerVAR_007031
18SERPING1p.Gly345ArgVAR_027376
19SERPING1p.Cys130TyrVAR_027379
20SERPING1p.Thr394ProVAR_027380
21SERPING1p.Asp408ValVAR_027381
22SERPING1p.Val473GluVAR_027382
23SERPING1p.Gly493GluVAR_027383
24SERPING1p.Pro498ArgVAR_027384
25SERPING1p.Thr118AlaVAR_068832rs200534715
26SERPING1p.Tyr154CysVAR_068833rs281875168
27SERPING1p.Ser170PheVAR_068834rs281875169
28SERPING1p.Gly184ArgVAR_068835rs281875170
29SERPING1p.Leu230ProVAR_068836rs281875171
30SERPING1p.Ile232LysVAR_068837rs281875172
31SERPING1p.Trp299ArgVAR_068839rs281875173
32SERPING1p.Leu430GlnVAR_068840rs281875174
33SERPING1p.Met441ThrVAR_068841rs281875175
34SERPING1p.Leu447ProVAR_068842rs281875176
35SERPING1p.Val473GlyVAR_068843rs281875177
36SERPING1p.Asp497GlyVAR_068844rs281875178
37SERPING1p.Leu11ArgVAR_071701
38SERPING1p.Trp265ArgVAR_071702
39SERPING1p.Ile274ValVAR_071703
40SERPING1p.Gly493ArgVAR_071704

Clinvar genetic disease variations for Angioedema, Hereditary, Types I and Ii:

5
id Gene Variation Type Significance SNP ID Assembly Location
1F12NM_000505.3(F12): c.983C> A (p.Thr328Lys)SNVPathogenicrs118204456GRCh37Chr 5, 176831232: 176831232
2SERPING1SERPING1, EX7DELdeletionPathogenicChr na, -1: -1
3SERPING1SERPING1, 1-BP INS, 1304AinsertionPathogenicChr na, -1: -1
4SERPING1SERPING1, 1-BP DEL, 1298TdeletionPathogenicChr na, -1: -1
5SERPING1SERPING1, IVS6, G-T, +1SNVPathogenicChr na, -1: -1
6SERPING1SERPING1, 1-BP DEL, 11698CdeletionPathogenicChr na, -1: -1
7SERPING1NM_000062.2(SERPING1): c.597C> G (p.Tyr199Ter)SNVPathogenicrs121907951GRCh37Chr 11, 57369554: 57369554

Expression for genes affiliated with Angioedema, Hereditary, Types I and Ii

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Search GEO for disease gene expression data for Angioedema, Hereditary, Types I and Ii.

Pathways for genes affiliated with Angioedema, Hereditary, Types I and Ii

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Pathways related to Angioedema, Hereditary, Types I and Ii according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4F12, KLKB1, SERPING1
29.2F12, KLK4, KLKB1
39.1C1R, C1S, C4B
4
Show member pathways
9.1F12, KLKB1, KNG1, SERPING1
5
Show member pathways
8.9F12, KLK4, KLKB1, KNG1
68.8C1R, C1S, C4B, SERPING1
7
Show member pathways
8.3C1R, C1S, C4B, CR1
8
Show member pathways
8.0C1R, C1S, C4B, CR1, SERPING1
9
Show member pathways
6.5BDKRB2, C1R, C1S, C4B, CR1, F12

GO Terms for genes affiliated with Angioedema, Hereditary, Types I and Ii

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Cellular components related to Angioedema, Hereditary, Types I and Ii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:003109310.5KNG1, SERPING1
2extracellular spaceGO:00056158.7C4B, F12, KLKB1, KNG1, SERPING1
3blood microparticleGO:00725628.5C1R, C1S, C4B, KNG1, SERPING1
4extracellular regionGO:00055767.4C1R, C1S, C4B, F12, KLK4, KLKB1
5extracellular exosomeGO:00700626.9C1R, C1S, C4B, CR1, F12, KLKB1

Biological processes related to Angioedema, Hereditary, Types I and Ii according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1Factor XII activationGO:000254210.4F12, KLKB1
2positive regulation of fibrinolysisGO:005191910.4F12, KLKB1
3smooth muscle contractionGO:000693910.3BDKRB2, KNG1
4zymogen activationGO:003163810.2F12, KLKB1
5blood circulationGO:000801510.1BDKRB2, SERPING1
6fibrinolysisGO:004273010.0F12, KLKB1, SERPING1
7negative regulation of endopeptidase activityGO:001095110.0C4B, KNG1, SERPING1
8regulation of complement activationGO:00304499.8C4B, CR1
9blood coagulation, intrinsic pathwayGO:00075979.7F12, KLKB1, KNG1, SERPING1
10complement activationGO:00069569.7C1R, C1S, C4B
11vasodilationGO:00423119.7BDKRB2, KNG1
12complement activation, classical pathwayGO:00069588.6C1R, C1S, C4B, CR1, SERPING1
13proteolysisGO:00065088.1C1R, C1S, C4B, KLK4, KLKB1
14innate immune responseGO:00450878.0C1R, C1S, C4B, CR1, F12, SERPING1

Molecular functions related to Angioedema, Hereditary, Types I and Ii according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type peptidase activityGO:00082369.3C1R, KLK4
2serine-type endopeptidase activityGO:00042527.5C1R, C1S, C4B, F12, KLK4, KLKB1

Sources for Angioedema, Hereditary, Types I and Ii

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet