AAE
MCID: ANG049
MIFTS: 33

Angioedema Induced by Ace Inhibitors (AAE) malady

Bone diseases, Immune diseases, Rare diseases categories
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Summaries for Angioedema Induced by Ace Inhibitors

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Sources:
47OMIM, 33MalaCards
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MalaCards: Angioedema Induced by Ace Inhibitors, also known as acquired angioedema, is related to angioedema and acquired angioedema, and has symptoms including cutaneous edema, urticaria and acute abdominal pain/colic. An important gene associated with Angioedema Induced by Ace Inhibitors is XPNPEP2 (X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound). Affiliated tissues include tongue and bone.

Description from OMIM:47 300909

Aliases & Classifications for Angioedema Induced by Ace Inhibitors

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Sources:
49Orphanet, 62UMLS, 47OMIM, 36MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
acquired angioedema:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood
renin-angiotensin-aldosterone system-blocker-induced angioneurotic edema:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

angioedema induced by ace inhibitors 47
acquired angioedema 49 62
renin-angiotensin-aldosterone system-blocker-induced angioneurotic edema 49
renin-angiotensin-aldosterone system-blocker-induced angioedema 49
acquired non histamine-induced angioedema 49
raas-blocker-induced angioneurotic edema 49
acquired bradykinine-induced angioedema 49
acquired c1 inhibitor deficiency 49
raas-blocker-induced angioedema 49
acquired angioneurotic edema 49
aae 49
rae 49


External Ids:

OMIM47 300909
MESH via Orphanet36 C538173
ICD10 via Orphanet26 T78.3
UMLS via Orphanet63 C2931758

Related Diseases for Angioedema Induced by Ace Inhibitors

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Angioedema Induced by Ace Inhibitors:



Diseases related to angioedema induced by ace inhibitors

Symptoms for Angioedema Induced by Ace Inhibitors

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Sources:
47OMIM, 49Orphanet
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Clinical features from OMIM:

300909

Symptoms:

49
  • cutaneous edema
  • urticaria
  • acute abdominal pain/colic
  • intestinal obstruction/ileus
  • severe allergic reaction/atopy
  • angioedema/angioneurotic edema

Drugs & Therapeutics for Angioedema Induced by Ace Inhibitors

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Angioedema Induced by Ace Inhibitors

Search NIH Clinical Center for Angioedema Induced by Ace Inhibitors

Genetic Tests for Angioedema Induced by Ace Inhibitors

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Anatomical Context for Angioedema Induced by Ace Inhibitors

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33MalaCards
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MalaCards organs/tissues related to Angioedema Induced by Ace Inhibitors:

33
Tongue, Bone

Animal Models for Angioedema Induced by Ace Inhibitors or affiliated genes

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Publications for Angioedema Induced by Ace Inhibitors

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Sources:
52PubMed
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Articles related to Angioedema Induced by Ace Inhibitors:

idTitleAuthorsYear
1
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? (20163043)
2009
2
Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases]. (10198947)
1999

Variations for Angioedema Induced by Ace Inhibitors

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Expression for genes affiliated with Angioedema Induced by Ace Inhibitors

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angioedema Induced by Ace Inhibitors

Search GEO for disease gene expression data for Angioedema Induced by Ace Inhibitors.

Pathways for genes affiliated with Angioedema Induced by Ace Inhibitors

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Compounds for genes affiliated with Angioedema Induced by Ace Inhibitors

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GO Terms for genes affiliated with Angioedema Induced by Ace Inhibitors

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Sources:
16Gene Ontology
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Cellular components related to Angioedema Induced by Ace Inhibitors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.1XPNPEP2, ACE
2extracellular vesicular exosomeGO:0700628.8XPNPEP2, ACE

Molecular functions related to Angioedema Induced by Ace Inhibitors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:0082379.1XPNPEP2, ACE

Products for genes affiliated with Angioedema Induced by Ace Inhibitors

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angioedema Induced by Ace Inhibitors

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet