MCID: ANG049
MIFTS: 25

Angioedema Induced by Ace Inhibitors

Categories: Genetic diseases, Bone diseases, Immune diseases, Rare diseases

Aliases & Classifications for Angioedema Induced by Ace Inhibitors

MalaCards integrated aliases for Angioedema Induced by Ace Inhibitors:

Name: Angioedema Induced by Ace Inhibitors 53 71
Angioedema Induced by Ace Inhibitors, Susceptibility to 53 28
Acquired Angioedema 55 69
Aeacei 53 71
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioneurotic Edema 55
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema 55
Drug-Related Side Effects and Adverse Reactions 41
Acquired Non Histamine-Induced Angioedema 55
Raas-Blocker-Induced Angioneurotic Edema 55
Acquired Bradykinine-Induced Angioedema 55
Acquired C1 Inhibitor Deficiency 55
Raas-Blocker-Induced Angioedema 55
Acquired Angioneurotic Edema 55
Ae-Acei 71
Rae 55
Aae 55

Characteristics:

Orphanet epidemiological data:

55
acquired angioedema
Inheritance: Not applicable; Age of onset: Adult;
renin-angiotensin-aldosterone system-blocker-induced angioedema
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

OMIM 53 300909
MESH via Orphanet 42 C538173
UMLS via Orphanet 70 C2931758
ICD10 via Orphanet 33 T78.3
SNOMED-CT via HPO 65 400075008 41291007
UMLS 69 C2931758

Summaries for Angioedema Induced by Ace Inhibitors

OMIM : 53 Approximately 40 million people take ACE inhibitors (ACEi) to treat hypertension and cardiovascular disease. A small proportion of white patients who take ACEi (0.1-0.7%) develop angioedema (AEACEI) (Israili and Hall, 1992; Vleeming et al., 1998), a potentially life-threatening side effect characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe. ACEi-associated angioedema is 4 to 5 times more prevalent among African Americans (Brown et al., 1996; Coats, 2002). Other risk factors include female sex, smoking, immunosuppressant therapy, and seasonal allergies. The pathophysiology of ACEi-associated angioedema is thought to be related to increased circulating bradykinin, which is normally degraded by ACE. During pharmacologic ACE inhibition, bradykinin is primarily degraded by aminopeptidase P (summary by Duan et al., 2005 and Woodard-Grice et al., 2010). Aminopeptidase P is encoded by 3 genes: XPNPEP1 (602443) on chromosome 10q25, XPNPEP2 (300145) on chromosome Xq25, and XPNPEP3 (613553) on chromosome 22q13. (300909)

MalaCards based summary : Angioedema Induced by Ace Inhibitors, also known as angioedema induced by ace inhibitors, susceptibility to, is related to acquired angioedema and acquired angioedema type 2, and has symptoms including angioedema, facial edema and edema. An important gene associated with Angioedema Induced by Ace Inhibitors is XPNPEP2 (X-Prolyl Aminopeptidase 2). Affiliated tissues include tongue and bone.

UniProtKB/Swiss-Prot : 71 Angioedema induced by ACE inhibitors: A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe.

Related Diseases for Angioedema Induced by Ace Inhibitors

Diseases related to Angioedema Induced by Ace Inhibitors via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 acquired angioedema 12.5
2 acquired angioedema type 2 12.2
3 acquired angioedema type 1 12.1
4 angioedema, hereditary, type i 11.3
5 reactive angioendotheliomatosis 10.9
6 angioedema 10.1
7 neuronitis 10.0

Graphical network of the top 20 diseases related to Angioedema Induced by Ace Inhibitors:



Diseases related to Angioedema Induced by Ace Inhibitors

Symptoms & Phenotypes for Angioedema Induced by Ace Inhibitors

Clinical features from OMIM:

300909

Human phenotypes related to Angioedema Induced by Ace Inhibitors:

55 31 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 angioedema 55 31 Very frequent (99-80%) HP:0100665
2 facial edema 55 Occasional (29-5%)
3 edema 55 Very frequent (99-80%)
4 urticaria 55 Occasional (29-5%)
5 ascites 55 Occasional (29-5%)
6 abdominal pain 55 Very frequent (99-80%)
7 intestinal obstruction 55 Occasional (29-5%)
8 intestinal edema 55 Occasional (29-5%)
9 laryngeal edema 55 Occasional (29-5%)

Drugs & Therapeutics for Angioedema Induced by Ace Inhibitors

Search Clinical Trials , NIH Clinical Center for Angioedema Induced by Ace Inhibitors

Cochrane evidence based reviews: drug-related side effects and adverse reactions

Genetic Tests for Angioedema Induced by Ace Inhibitors

Genetic tests related to Angioedema Induced by Ace Inhibitors:

# Genetic test Affiliating Genes
1 Angioedema Induced by Ace Inhibitors, Susceptibility to 28 XPNPEP2

Anatomical Context for Angioedema Induced by Ace Inhibitors

MalaCards organs/tissues related to Angioedema Induced by Ace Inhibitors:

38
Tongue, Bone

Publications for Angioedema Induced by Ace Inhibitors

Articles related to Angioedema Induced by Ace Inhibitors:

# Title Authors Year
1
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? ( 20163043 )
2009
2
[Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases]. ( 10198947 )
1999

Variations for Angioedema Induced by Ace Inhibitors

ClinVar genetic disease variations for Angioedema Induced by Ace Inhibitors:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 XPNPEP2 NG_011479.1: g.2846C> A single nucleotide variant risk factor rs3788853 GRCh37 Chromosome X, 128870791: 128870791

Expression for Angioedema Induced by Ace Inhibitors

Search GEO for disease gene expression data for Angioedema Induced by Ace Inhibitors.

Pathways for Angioedema Induced by Ace Inhibitors

GO Terms for Angioedema Induced by Ace Inhibitors

Sources for Angioedema Induced by Ace Inhibitors

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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