AAE
MCID: ANG049
MIFTS: 33

Angioedema Induced by Ace Inhibitors (AAE) malady

Bone diseases, Immune diseases, Rare diseases categories

Summaries for Angioedema Induced by Ace Inhibitors

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Sources:
48OMIM, 34MalaCards
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MalaCards: Angioedema Induced by Ace Inhibitors, also known as acquired angioedema, is related to angioedema and acquired angioedema, and has symptoms including cutaneous edema, urticaria and acute abdominal pain/colic. An important gene associated with Angioedema Induced by Ace Inhibitors is XPNPEP2 (X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound). Affiliated tissues include tongue and bone.

Description from OMIM:48 300909

Aliases & Classifications for Angioedema Induced by Ace Inhibitors

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Sources:
50Orphanet, 63UMLS, 48OMIM, 37MESH via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

50
acquired angioedema:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood
renin-angiotensin-aldosterone system-blocker-induced angioneurotic edema:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

angioedema induced by ace inhibitors 48
acquired angioedema 50 63
renin-angiotensin-aldosterone system-blocker-induced angioneurotic edema 50
renin-angiotensin-aldosterone system-blocker-induced angioedema 50
acquired non histamine-induced angioedema 50
raas-blocker-induced angioneurotic edema 50
acquired bradykinine-induced angioedema 50
acquired c1 inhibitor deficiency 50
raas-blocker-induced angioedema 50
acquired angioneurotic edema 50
aae 50
rae 50


External Ids:

OMIM48 300909
MESH via Orphanet37 C538173
ICD10 via Orphanet27 T78.3
UMLS via Orphanet64 C2931758

Related Diseases for Angioedema Induced by Ace Inhibitors

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Angioedema Induced by Ace Inhibitors:



Diseases related to angioedema induced by ace inhibitors

Symptoms for Angioedema Induced by Ace Inhibitors

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Sources:
48OMIM, 50Orphanet
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Clinical features from OMIM:

300909

Symptoms:

50
  • cutaneous edema
  • urticaria
  • acute abdominal pain/colic
  • intestinal obstruction/ileus
  • severe allergic reaction/atopy
  • angioedema/angioneurotic edema

Drugs & Therapeutics for Angioedema Induced by Ace Inhibitors

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Angioedema Induced by Ace Inhibitors

Drug clinical trials:

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Search NIH Clinical Center for Angioedema Induced by Ace Inhibitors

Search CenterWatch for Angioedema Induced by Ace Inhibitors

Genetic Tests for Angioedema Induced by Ace Inhibitors

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Anatomical Context for Angioedema Induced by Ace Inhibitors

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Sources:
34MalaCards
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MalaCards organs/tissues related to Angioedema Induced by Ace Inhibitors:

34
Tongue, Bone

Animal Models for Angioedema Induced by Ace Inhibitors or affiliated genes

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Publications for Angioedema Induced by Ace Inhibitors

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Sources:
53PubMed
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Articles related to Angioedema Induced by Ace Inhibitors:

idTitleAuthorsYear
1
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? (20163043)
2009
2
Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases]. (10198947)
1999

Variations for Angioedema Induced by Ace Inhibitors

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Expression for genes affiliated with Angioedema Induced by Ace Inhibitors

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angioedema Induced by Ace Inhibitors

Search GEO for disease gene expression data for Angioedema Induced by Ace Inhibitors.

Pathways for genes affiliated with Angioedema Induced by Ace Inhibitors

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Compounds for genes affiliated with Angioedema Induced by Ace Inhibitors

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GO Terms for genes affiliated with Angioedema Induced by Ace Inhibitors

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Sources:
17Gene Ontology
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Cellular components related to Angioedema Induced by Ace Inhibitors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.1XPNPEP2, ACE
2extracellular vesicular exosomeGO:0700628.8XPNPEP2, ACE

Molecular functions related to Angioedema Induced by Ace Inhibitors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:0082379.1XPNPEP2, ACE

Products for genes affiliated with Angioedema Induced by Ace Inhibitors

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angioedema Induced by Ace Inhibitors

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet