AAE
MCID: ANG049
MIFTS: 33

Angioedema Induced by Ace Inhibitors (AAE) malady

Bone diseases, Immune diseases, Rare diseases categories

Summaries for Angioedema Induced by Ace Inhibitors

About this section


OMIM:46 Approximately 40 million people take ACE inhibitors (ACEi) to treat hypertension and cardiovascular disease. A small...300909 more...

MalaCards based summary: Angioedema Induced by Ace Inhibitors, also known as acquired angioneurotic edema, is related to angioedema and acquired angioedema, and has symptoms including edema, urticaria and abdominal pain. An important gene associated with Angioedema Induced by Ace Inhibitors is XPNPEP2 (X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound). Affiliated tissues include tongue and bone.

Aliases & Classifications for Angioedema Induced by Ace Inhibitors

About this section
Sources:
46OMIM, 48Orphanet, 61UMLS, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Angioedema Induced by Ace Inhibitors, Aliases & Descriptions:

Name: Angioedema Induced by Ace Inhibitors 46
Acquired Angioneurotic Edema 48 61
Acquired Angioedema 48 61
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioneurotic Edema 48
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema 48
Acquired Non Histamine-Induced Angioedema 48
 
Raas-Blocker-Induced Angioneurotic Edema 48
Acquired Bradykinine-Induced Angioedema 48
Acquired C1 Inhibitor Deficiency 48
Raas-Blocker-Induced Angioedema 48
Rae 48
Aae 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
acquired angioneurotic edema:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood
renin-angiotensin-aldosterone system-blocker-induced angioneurotic edema:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Adulthood


External Ids:

OMIM46 300909
MESH via Orphanet35 C538173
ICD10 via Orphanet27 T78.3
UMLS via Orphanet62 C2931758

Related Diseases for Angioedema Induced by Ace Inhibitors

About this section

Graphical network of the top 20 diseases related to Angioedema Induced by Ace Inhibitors:



Diseases related to angioedema induced by ace inhibitors

Symptoms for Angioedema Induced by Ace Inhibitors

About this section


Clinical features from OMIM:

300909

Symptoms:

 48
  • urticaria
  • cutaneous edema
  • acute abdominal pain/colic
  • angioedema/angioneurotic edema
  • intestinal obstruction/ileus
  • severe allergic reaction/atopy

HPO human phenotypes related to Angioedema Induced by Ace Inhibitors:

id Description Frequency HPO Source Accession
1 edema hallmark (90%) HP:0000969
2 urticaria hallmark (90%) HP:0001025
3 abdominal pain hallmark (90%) HP:0002027
4 intestinal obstruction occasional (7.5%) HP:0005214
5 immunologic hypersensitivity occasional (7.5%) HP:0100326

Drugs & Therapeutics for Angioedema Induced by Ace Inhibitors

About this section

Drug clinical trials:

Search ClinicalTrials for Angioedema Induced by Ace Inhibitors

Search NIH Clinical Center for Angioedema Induced by Ace Inhibitors

Genetic Tests for Angioedema Induced by Ace Inhibitors

About this section

Anatomical Context for Angioedema Induced by Ace Inhibitors

About this section

MalaCards organs/tissues related to Angioedema Induced by Ace Inhibitors:

32
Tongue, Bone

Animal Models for Angioedema Induced by Ace Inhibitors or affiliated genes

About this section

Publications for Angioedema Induced by Ace Inhibitors

About this section

Articles related to Angioedema Induced by Ace Inhibitors:

idTitleAuthorsYear
1
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? (20163043)
2009
2
Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases]. (10198947)
1999

Variations for Angioedema Induced by Ace Inhibitors

About this section

Clinvar genetic disease variations for Angioedema Induced by Ace Inhibitors:

7
id Gene Name Type Significance SNP ID Assembly Location
1XPNPEP2NG_011479.1: g.2846C> Asingle nucleotide variantrisk factorrs3788853GRCh37Chr X, 128870791: 128870791

Expression for genes affiliated with Angioedema Induced by Ace Inhibitors

About this section
Expression patterns in normal tissues for genes affiliated with Angioedema Induced by Ace Inhibitors

Search GEO for disease gene expression data for Angioedema Induced by Ace Inhibitors.

Pathways for genes affiliated with Angioedema Induced by Ace Inhibitors

About this section

Compounds for genes affiliated with Angioedema Induced by Ace Inhibitors

About this section

GO Terms for genes affiliated with Angioedema Induced by Ace Inhibitors

About this section

Cellular components related to Angioedema Induced by Ace Inhibitors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.1XPNPEP2, ACE
2extracellular vesicular exosomeGO:0700628.8XPNPEP2, ACE

Molecular functions related to Angioedema Induced by Ace Inhibitors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:0082379.1XPNPEP2, ACE

Products for genes affiliated with Angioedema Induced by Ace Inhibitors

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Angioedema Induced by Ace Inhibitors

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet