MCID: ANG049
MIFTS: 21

Angioedema Induced by Ace Inhibitors malady

Category: Genetic diseases (common)

Aliases & Classifications for Angioedema Induced by Ace Inhibitors

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Aliases & Descriptions for Angioedema Induced by Ace Inhibitors:

Name: Angioedema Induced by Ace Inhibitors 49 67 24
Ae-Acei 67
 
Aeacei 67

Classifications:



External Ids:

OMIM49 300909
MedGen34 CN069588

Summaries for Angioedema Induced by Ace Inhibitors

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OMIM:49 Approximately 40 million people take ACE inhibitors (ACEi) to treat hypertension and cardiovascular disease. A small... (300909) more...

MalaCards based summary: Angioedema Induced by Ace Inhibitors, also known as ae-acei, is related to angioedema, hereditary, types i and ii and angioedema, and has symptoms including abdominal pain, urticaria and edema. An important gene associated with Angioedema Induced by Ace Inhibitors is XPNPEP2 (X-Prolyl Aminopeptidase (Aminopeptidase P) 2, Membrane-Bound). Affiliated tissues include tongue.

UniProtKB/Swiss-Prot:67 Angioedema induced by ACE inhibitors: A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe.

Related Diseases for Angioedema Induced by Ace Inhibitors

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Diseases related to Angioedema Induced by Ace Inhibitors via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1angioedema, hereditary, types i and ii10.4
2angioedema10.1

Symptoms for Angioedema Induced by Ace Inhibitors

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Clinical features from OMIM:

300909

HPO human phenotypes related to Angioedema Induced by Ace Inhibitors:

(show all 6)
id Description Frequency HPO Source Accession
1 abdominal pain hallmark (90%) HP:0002027
2 urticaria hallmark (90%) HP:0001025
3 edema hallmark (90%) HP:0000969
4 immunologic hypersensitivity occasional (7.5%) HP:0100326
5 intestinal obstruction occasional (7.5%) HP:0005214
6 angioedema HP:0100665

Drugs & Therapeutics for Angioedema Induced by Ace Inhibitors

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Drugs for Angioedema Induced by Ace Inhibitors (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IcatibantapprovedPhase 3, Phase 216138614-30-9, 130308-48-471364
Synonyms:
(2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
(2s)-2-({[(3as,7as)-1-({2-[(2s)-2-{[(2s)-2-({[({(4r)-1-[(1-{2-({(2r)-2-amino-5-[(diaminomethylidene)amino]pentanoyl}amino)-5-[(diaminomethylidene)amino]pentanoyl}pyrrolidin-2-yl)carbonyl]-4-hydroxypyrrolidin-2-yl}carbonyl)amino]acetyl}amino)-3-(thiophen-2-yl)propanoyl]amino}-3-hydroxypropanoyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}carbonyl)octahydro-1h-indol-2-yl]carbonyl}amino)-5-[(diaminomethylidene)amino]pentanoic acid(non-preferred name)
130308-48-4
138614-30-9 (acetate)
13996-86-6
153322-84-0
AC1L2G0Q
AC1Q5QRX
AR-1A3141
C59H89N19O13S
CHEBI:163731
CHEMBL411169
CID71364
 
D-Arg(Hyp(3)-Thi(5)-D-Tic(7)-Oic(8))BK
DB06196
Firazyr
HOE 140
HOE140
Hoe-140
Icatibant
Icatibant Acetate
Icatibant [INN]
JE049
KST-1A1301
LS-172762
WIN 65365
WIN-65365
2HIV Protease InhibitorsPhase 3, Phase 24558
3AnalgesicsPhase 3, Phase 29358
4Immunologic FactorsPhase 3, Phase 218483
5Immunosuppressive AgentsPhase 3, Phase 210422
6Protease InhibitorsPhase 3, Phase 24558
7Peripheral Nervous System AgentsPhase 3, Phase 218510
8KininogensPhase 3, Phase 247
9Complement Inactivating AgentsPhase 3, Phase 271
10Complement System ProteinsPhase 3, Phase 2190
11Bradykinin Receptor AntagonistsPhase 3, Phase 217
12Angiotensin-Converting Enzyme InhibitorsPhase 3, Phase 2634
13Analgesics, Non-NarcoticPhase 3, Phase 25184
14Anti-Inflammatory Agents, Non-SteroidalPhase 3, Phase 23549
15Anti-Inflammatory AgentsPhase 3, Phase 28478
16Antirheumatic AgentsPhase 3, Phase 28496
17Bradykinin B2 Receptor AntagonistsPhase 3, Phase 213
18
BradykininPhase 3, Phase 24758-82-2439201
Synonyms:
Callidin I
Kallidin 9
 
Kallidin I
L-Arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-Arginine
L-Bradykinin
19
Cortisone acetateapprovedPhase 2531950-04-4, 50-04-45745
Synonyms:
Cortisone Acetate
 
Cortisyl
Cortone acetate
20
CortisonePhase 25353-06-5222786
Synonyms:
Andreson
Anusol HC
Balneol-Hc
Colocort
Compound E
Corlin
Cortadren
Cortandren
Cortef
Cortef Acetate
Cortisal
Cortisate
Cortison
Cortisone Acetate
Cortistal
Cortivite
Cortogen
Cortone
Cortril
Dermacort
Dricort
Flexicort
 
Florinef
Fludrocortisone Acetate
Glycort
Hemsol-Hc
Hi-Cor
Incortin
Kendall'S Compound E
Kendall'S compound
Locoid
Locoid Lipocream
Micort-Hc
Nogenic HC
Orabase HCA
Pandel
Prestwick_132
Reichstein Fa
Reichstein'S Substance FA
Scheroson
Solu-Cortef
Stie-Cort
Texacort
Westcort
beta-Hc
21KallikreinsPhase 221

Interventional clinical trials:

idNameStatusNCT IDPhase
1Blinded Safety & Efficacy Placebo Controlled Study of Icatibant for Angiotensin Converting Enzyme Inhibitor Induced AngioedemaCompletedNCT01919801Phase 3
2AMelioration of Angiotensin Converting Enzyme Inhibitor Induced Angioedema StudyCompletedNCT01154361Phase 2
3Evaluation of Ecallantide for the Acute Treatment of Angiotensin Converting Enzyme Inhibitor Induced AngioedemaRecruitingNCT01036659Phase 2
4Evaluation of Ecallantide for Treatment of Angiotensin Converting Enzyme (ACE) Inhibitor Induced AngioedemaTerminatedNCT01343823Phase 2

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Genetic Tests for Angioedema Induced by Ace Inhibitors

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Anatomical Context for Angioedema Induced by Ace Inhibitors

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MalaCards organs/tissues related to Angioedema Induced by Ace Inhibitors:

33
Tongue

Animal Models for Angioedema Induced by Ace Inhibitors or affiliated genes

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Publications for Angioedema Induced by Ace Inhibitors

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Articles related to Angioedema Induced by Ace Inhibitors:

idTitleAuthorsYear
1
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? (20163043)
2009
2
Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases]. (10198947)
1999

Variations for Angioedema Induced by Ace Inhibitors

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Clinvar genetic disease variations for Angioedema Induced by Ace Inhibitors:

5
id Gene Variation Type Significance SNP ID Assembly Location
1XPNPEP2NG_011479.1: g.2846C> Asingle nucleotide variantrisk factorrs3788853GRCh37Chr X, 128870791: 128870791

Expression for genes affiliated with Angioedema Induced by Ace Inhibitors

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Search GEO for disease gene expression data for Angioedema Induced by Ace Inhibitors.

Pathways for genes affiliated with Angioedema Induced by Ace Inhibitors

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GO Terms for genes affiliated with Angioedema Induced by Ace Inhibitors

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Sources for Angioedema Induced by Ace Inhibitors

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet