AAE
MCID: ANG049
MIFTS: 33

Angioedema Induced by Ace Inhibitors (AAE) malady

Bone diseases, Immune diseases, Rare diseases categories
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Summaries for Angioedema Induced by Ace Inhibitors

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MalaCards based summary: Angioedema Induced by Ace Inhibitors, also known as acquired angioneurotic edema, is related to angioedema and acquired angioedema, and has symptoms including urticaria, cutaneous edema and acute abdominal pain/colic. An important gene associated with Angioedema Induced by Ace Inhibitors is XPNPEP2 (X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound). Affiliated tissues include tongue and bone.

Description from OMIM:46 300909

Aliases & Classifications for Angioedema Induced by Ace Inhibitors

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Sources:
46OMIM, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Angioedema Induced by Ace Inhibitors, Aliases & Descriptions:

Name: Angioedema Induced by Ace Inhibitors 46
Acquired Angioneurotic Edema 48 62
Acquired Angioedema 48 62
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioneurotic Edema 48
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema 48
Acquired Non Histamine-Induced Angioedema 48
 
Raas-Blocker-Induced Angioneurotic Edema 48
Acquired Bradykinine-Induced Angioedema 48
Acquired C1 Inhibitor Deficiency 48
Raas-Blocker-Induced Angioedema 48
Rae 48
Aae 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
acquired angioneurotic edema:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood
renin-angiotensin-aldosterone system-blocker-induced angioneurotic edema:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Adulthood


External Ids:

OMIM46 300909
MESH via Orphanet35 C538173
ICD10 via Orphanet26 T78.3
UMLS via Orphanet63 C2931758

Related Diseases for Angioedema Induced by Ace Inhibitors

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Graphical network of the top 20 diseases related to Angioedema Induced by Ace Inhibitors:



Diseases related to angioedema induced by ace inhibitors

Symptoms for Angioedema Induced by Ace Inhibitors

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Clinical features from OMIM:

300909

Symptoms:

48
  • urticaria
  • cutaneous edema
  • acute abdominal pain/colic
  • angioedema/angioneurotic edema
  • intestinal obstruction/ileus
  • severe allergic reaction/atopy

HPO human phenotypes related to Angioedema Induced by Ace Inhibitors:

id Description Frequency HPO Source Accession
1 edema hallmark (90%) HP:0000969
2 urticaria hallmark (90%) HP:0001025
3 abdominal pain hallmark (90%) HP:0002027
4 intestinal obstruction occasional (7.5%) HP:0005214
5 immunologic hypersensitivity occasional (7.5%) HP:0100326

Drugs & Therapeutics for Angioedema Induced by Ace Inhibitors

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Drug clinical trials:

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Search NIH Clinical Center for Angioedema Induced by Ace Inhibitors

Genetic Tests for Angioedema Induced by Ace Inhibitors

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Anatomical Context for Angioedema Induced by Ace Inhibitors

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MalaCards organs/tissues related to Angioedema Induced by Ace Inhibitors:

32
Tongue, Bone

Animal Models for Angioedema Induced by Ace Inhibitors or affiliated genes

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Publications for Angioedema Induced by Ace Inhibitors

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Articles related to Angioedema Induced by Ace Inhibitors:

idTitleAuthorsYear
1
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? (20163043)
2009
2
Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases]. (10198947)
1999

Variations for Angioedema Induced by Ace Inhibitors

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Clinvar genetic disease variations for Angioedema Induced by Ace Inhibitors:

6
id Gene Name Type Significance SNP ID Assembly Location
1XPNPEP2NG_011479.1: g.2846C> Asingle nucleotide variantrisk factorrs3788853GRCh37Chr X, 128870791: 128870791

Expression for genes affiliated with Angioedema Induced by Ace Inhibitors

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Expression patterns in normal tissues for genes affiliated with Angioedema Induced by Ace Inhibitors

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Pathways for genes affiliated with Angioedema Induced by Ace Inhibitors

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Compounds for genes affiliated with Angioedema Induced by Ace Inhibitors

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GO Terms for genes affiliated with Angioedema Induced by Ace Inhibitors

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Cellular components related to Angioedema Induced by Ace Inhibitors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.1XPNPEP2, ACE
2extracellular vesicular exosomeGO:0700628.8XPNPEP2, ACE

Molecular functions related to Angioedema Induced by Ace Inhibitors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:0082379.1XPNPEP2, ACE

Products for genes affiliated with Angioedema Induced by Ace Inhibitors

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  • Antibodies
  • Proteins
  • Lysates

Sources for Angioedema Induced by Ace Inhibitors

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet