AILT
MCID: ANG046
MIFTS: 37

Angioimmunoblastic T-Cell Lymphoma (AILT) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Angioimmunoblastic T-Cell Lymphoma

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32MalaCards
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MalaCards: Angioimmunoblastic T-Cell Lymphoma, also known as immunoblastic lymphadenopathy, is related to hodgkin's lymphoma and leukemia. An important gene associated with Angioimmunoblastic T-Cell Lymphoma is MAF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog), and among its related pathways are Angiogenesis and Translocation of ZAP-70 to Immunological synapse. The compounds estrogen and serine have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Angioimmunoblastic T-Cell Lymphoma

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
angioimmunoblastic t-cell lymphoma:
Age of onset: Adulthood


Aliases & Descriptions:

angioimmunoblastic t-cell lymphoma 42 44 48
immunoblastic lymphadenopathy 42 48
t-cell lymphoma, aild type 42 48
lymphogranulomatosis x 42 48
ailt 42 48
angioimmunoblastic lymphadenopathy 60


External Ids:

ICD10 via Orphanet26 C84.4
SNOMED-CT via Orphanet57 413537009, 835009
ICD1025 C86.5

Related Diseases for Angioimmunoblastic T-Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Angioimmunoblastic T-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma30.8TIA1, GZMB, BCL6
2leukemia30.8TIA1, GZMB, MME, TEK, ENG, BCL6
3hepatitis30.4GZMB
4arthritis30.3TEK, GZMB
5mycosis fungoides30.3TIA1, GZMB
6sarcoma30.3ENG, TEK, MET
7rheumatoid arthritis30.3GZMB, PDCD1, MME, TEK, ENG
8squamous cell carcinoma30.3GZMB, CSTA, MET, VEGFC, TEK, ENG
9psoriasis30.1GZMB, CSTA, TEK, ENG
10melanoma30.1TIA1, GZMB, PDCD1, MET, VEGFC, MME
11cutaneous t cell lymphoma10.8
12bone lymphoma10.6
13diffuse large b-cell lymphoma10.6
14t-cell leukemia10.6
15pure red-cell aplasia10.5
16vasculitis10.5
17ankylosing spondylitis10.4
18polyarteritis nodosa10.4
19cervicitis10.4
20myelofibrosis10.4
21spondylitis10.4
22t cell deficiency10.4
23thrombocytopenia10.4
24kaposi's sarcoma10.3
25crohn's disease10.3
26cardiac tamponade10.3
27antiphospholipid syndrome10.3
28evans' syndrome10.3
29hemophagocytic lymphohistiocytosis10.3
30cerebritis10.3
31adult t-cell leukemia10.3
32proliferative glomerulonephritis10.3
33c1 inhibitor deficiency10.3
34pemphigus10.3
35progressive multifocal leukoencephalopathy10.3
36autoimmune hemolytic anemia10.3
37infectious mononucleosis10.3
38cerebral lymphoma10.3
39composite lymphoma10.3
40pediatric lymphoma10.3
41adult lymphoma10.3
42granuloma annulare10.3
43chikungunya10.3
44hepatitis a10.3
45b cell deficiency10.3
46cervical squamous cell carcinoma10.3
47chronic lymphocytic leukemia10.3
48endocarditis10.3
49glomerulonephritis10.3
50hemolytic anemia10.3

Graphical network of the top 20 diseases related to Angioimmunoblastic T-Cell Lymphoma:



Diseases related to angioimmunoblastic t-cell lymphoma

Clinical Features for Angioimmunoblastic T-Cell Lymphoma

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Drugs & Therapeutics for Angioimmunoblastic T-Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angioimmunoblastic T-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Angioimmunoblastic T-Cell Lymphoma

Search NIH Clinical Center for Angioimmunoblastic T-Cell Lymphoma

Search CenterWatch for Angioimmunoblastic T-Cell Lymphoma

Genetic Tests for Angioimmunoblastic T-Cell Lymphoma

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Anatomical Context for Angioimmunoblastic T-Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Angioimmunoblastic T-Cell Lymphoma:

32
T cells

Animal Models for Angioimmunoblastic T-Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angioimmunoblastic T-Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4ICOS, PDCD1LG2, MAF, CD200, BCL6
2MP:00107688.8GZMB, PDCD1, PDCD1LG2, MET, VEGFC, MAF
3MP:00053978.6PDCD1, ICOS, GZMB, TIA1, PDCD1LG2, CD200
4MP:00053878.5BCL6, TIA1, GZMB, ICOS, PDCD1, PDCD1LG2
5MP:00053848.3GZMB, ICOS, PDCD1, PDCD1LG2, MET, CD200

Publications for Angioimmunoblastic T-Cell Lymphoma

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Genetic Variations for Angioimmunoblastic T-Cell Lymphoma

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Expression for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

Search GEO for disease gene expression data for Angioimmunoblastic T-Cell Lymphoma.

Pathways for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

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Sources:
4Cell Signaling Technology, 53Reactome, 29KEGG
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Pathways related to Angioimmunoblastic T-Cell Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0ENG, TEK, VEGFC
2
Hide members
9.8TRBC1, PDCD1LG2, PDCD1
39.8GZMB, MET, MAF, BCL6
4
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9.7TRBC1, PDCD1LG2, PDCD1, ICOS

Compounds for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank
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Compounds related to Angioimmunoblastic T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3BCL6
2serine4410.1GZMB, TEK
3p0024410.0ENG, TEK, MET
4ribonucleic acid449.9GZMB, MET, VEGFC, MME, TEK
512-o-tetradecanoylphorbol 13-acetate449.9GZMB, CSTA, MET, MME, BCL6
6matrigel449.8CSTA, MET, VEGFC, MME, TEK, ENG
7vegf449.7GZMB, MET, VEGFC, MME, TEK, ENG
8oxygen44 2410.6ENG, TEK, MME, VEGFC, MET, GZMB
9cysteine449.5ENG, TEK, MME, MET, CSTA, GZMB
10doxorubicin44 49 1111.5BCL6, ENG, MME, MET
11paraffin449.4BCL6, TIA1, GZMB, MET, VEGFC, MME
12tyrosine449.2GZMB, PDCD1, CSTA, MET, VEGFC, MME

GO Terms for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

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Sources:
16Gene Ontology
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Biological processes related to Angioimmunoblastic T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1germinal center formationGO:00246710.1BCL6, CXCL13
2cell-cell adhesionGO:0163379.9ICOS, CSTA, TEK
3T cell costimulationGO:0312959.8TRBC1, PDCD1LG2, PDCD1, ICOS
4immune responseGO:0069559.7CXCL13, TRBC1, PDCD1LG2, ICOS
5regulation of immune responseGO:0507769.5BCL6, CD200, TRBC1

Products for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Angioimmunoblastic T-Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet