AILT
MCID: ANG046
MIFTS: 42

Angioimmunoblastic T-Cell Lymphoma (AILT) malady

Cancer, Blood, Immune categories

Summaries for Angioimmunoblastic T-Cell Lymphoma

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33MalaCards
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MalaCards: Angioimmunoblastic T-Cell Lymphoma, also known as immunoblastic lymphadenopathy, is related to lymphoma, diffuse large cell and peripheral t-cell lymphoma. An important gene associated with Angioimmunoblastic T-Cell Lymphoma is MAF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog), and among its related pathways are Angiogenesis and Translocation of ZAP-70 to Immunological synapse. The compounds estrogen and serine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone marrow and t cells, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Angioimmunoblastic T-Cell Lymphoma

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
angioimmunoblastic t-cell lymphoma:
Age of onset: Adulthood


Aliases & Descriptions:

angioimmunoblastic t-cell lymphoma 43 45 49
immunoblastic lymphadenopathy 43 49
t-cell lymphoma, aild type 43 49
lymphogranulomatosis x 43 49
ailt 43 49
angioimmunoblastic lymphadenopathy 61


External Ids:

ICD10 via Orphanet26 C84.4
SNOMED-CT via Orphanet58 413537009, 835009
ICD1025 C86.5

Related Diseases for Angioimmunoblastic T-Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Angioimmunoblastic T-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell30.9MME, BCL6
2peripheral t-cell lymphoma30.9TIA1, GZMB, CXCL13, BCL6
3b-cell lymphomas30.6TIA1, GZMB, CXCL13, MME, BCL6
4arthritis30.4TEK, GZMB
5mycosis fungoides30.4TIA1, GZMB
6squamous cell carcinoma30.4GZMB, CSTA, MET, VEGFC, TEK, ENG
7follicular lymphoma10.8
8bone lymphoma10.6
9diffuse large b-cell lymphoma10.5
10vasculitis10.5
11ankylosing spondylitis10.4
12polyarteritis nodosa10.4
13spondylitis10.4
14thrombocytopenia10.4
15kaposi's sarcoma10.3
16cardiac tamponade10.3
17antiphospholipid syndrome10.3
18evans' syndrome10.3
19hemophagocytic lymphohistiocytosis10.3
20proliferative glomerulonephritis10.3
21pemphigus10.3
22progressive multifocal leukoencephalopathy10.3
23autoimmune hemolytic anemia10.3
24infectious mononucleosis10.3
25cerebral lymphoma10.3
26composite lymphoma10.3
27pediatric lymphoma10.3
28adult lymphoma10.3
29granuloma annulare10.3
30chikungunya10.3
31urticaria10.3
32angioimmunoblastic lymphadenopathy with dysproteinemia10.3
33chronic myelomonocytic leukemia10.3
34follicular dendritic cell tumor10.3
35plasma cell leukemia10.3
36lymphoblastic lymphoma10.3
37toxic epidermal necrolysis10.3
38primary malignant lymphoma10.3
39septic shock10.3
40lymphoma, somatic10.3
41primary bone lymphoma10.3
42paraneoplastic pemphigus10.3
43mucous membrane pemphigoid10.3
44cryoglobulinemia10.1
45miliary tuberculosis10.1
46asbestosis10.1
47sick sinus syndrome10.1
48tuberculosis10.1
49cold agglutinin disease10.1
50gout10.1

Graphical network of the top 20 diseases related to Angioimmunoblastic T-Cell Lymphoma:



Diseases related to angioimmunoblastic t-cell lymphoma

Clinical Features for Angioimmunoblastic T-Cell Lymphoma

Drugs & Therapeutics for Angioimmunoblastic T-Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Angioimmunoblastic T-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Angioimmunoblastic T-Cell Lymphoma

Search NIH Clinical Center for Angioimmunoblastic T-Cell Lymphoma

Search CenterWatch for Angioimmunoblastic T-Cell Lymphoma

Genetic Tests for Angioimmunoblastic T-Cell Lymphoma

Anatomical Context for Angioimmunoblastic T-Cell Lymphoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Angioimmunoblastic T-Cell Lymphoma:

33
Lymph node, Bone marrow, T cells, B lymphoblasts, B cells

Animal Models for Angioimmunoblastic T-Cell Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Angioimmunoblastic T-Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.4ICOS, PDCD1LG2, MAF, CD200, BCL6
2MP:00107688.8GZMB, PDCD1, PDCD1LG2, MET, VEGFC, MAF
3MP:00053978.6PDCD1, ICOS, GZMB, TIA1, PDCD1LG2, CD200
4MP:00053878.5BCL6, TIA1, GZMB, ICOS, PDCD1, PDCD1LG2
5MP:00053848.3GZMB, ICOS, PDCD1, PDCD1LG2, MET, CD200

Publications for Angioimmunoblastic T-Cell Lymphoma

Sources:
51PubMed
See all sources

Articles related to Angioimmunoblastic T-Cell Lymphoma:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Primary cutaneous follicular helper T-cell lymphoma treated with allogeneic bone marrow transplantation: immunohistochemical comparison with angioimmunoblastic T-cell lymphoma. (23756572)
2014
2
A targeted mutational landscape of angioimmunoblastic T cell lymphoma. (24345752)
2013
3
ITK/SYK translocation in angioimmunoblastic T-cell lymphoma. (24076779)
2013
4
Angioimmunoblastic T cell lymphoma in an ankylosing spondylitis patient treated with etanercept. (22791222)
2013
5
Successful treatment with rituximab for angioimmunoblastic T-cell lymphoma. (24371775)
2013
6
Peripheral blood sCD3(-) CD4(+) T cells: a useful diagnostic tool in angioimmunoblastic T cell lymphoma. (23798351)
2013
7
Therapy refractory angioimmunoblastic T-cell lymphoma in complete remission with lenalidomide. (23227803)
2013
8
IgA Paraneoplastic Pemphigus in Angioimmunoblastic T-cell Lymphoma with Antibodies to Desmocollin 1, Type VII Collagen and Laminin 332. (23824361)
2013
9
Angioimmunoblastic T-cell lymphoma: the effect of initial treatment and microvascular density in 31 patients. (22038726)
2012
10
Bortezomib-based treatment for relapsed and refractory angioimmunoblastic T-cell lymphoma: Case report and literature review. (22844366)
2012
11
TdT+ T-lymphoblastic populations are increased in Castleman disease, in Castleman disease in association with follicular dendritic cell tumors, and in angioimmunoblastic T-cell lymphoma. (23060347)
2012
12
Angioimmunoblastic T-cell lymphoma, combined with antiphospholipid syndrome and autoimmune thrombocytopenia (case report). (22192653)
2012
13
Impressive activity of lenalidomide monotherapy in refractory angioimmunoblastic T-cell lymphoma: report of a case with long-term follow-up. (23161606)
2012
14
Successful treatment of chemotherapy-refractory angioimmunoblastic T cell lymphoma with cyclosporin A. (21986307)
2012
15
BCL2 expression in CD105 positive neoangiogenic cells and tumor progression in angioimmunoblastic T-cell lymphoma. (22322190)
2012
16
Reduced intensity conditioning allogeneic hematopoietic stem cell transplant could be beneficial to angioimmunoblastic T-cell lymphoma patients with hemophagocytic lymphohistiocytosis. (21894473)
2012
17
Cyclosporine A and reduced-intensity conditioning allogeneic stem cell transplantation for relapsed angioimmunoblastic T cell lymphoma with hemophagocytic syndrome. (23037475)
2012
18
False-positive human immunodeficiency virus antibody test and autoimmune hemolytic anemia in a patient with angioimmunoblastic T-cell lymphoma. (22001471)
2011
19
Successful treatment of angioimmunoblastic T-cell lymphoma with the retinoid X receptor agonist, bexarotene. (21585279)
2011
20
Clinical features and prognostic factors of angioimmunoblastic T-cell lymphoma in Taiwan: a single-institution experience. (21054150)
2010
21
Allogeneic stem cell transplantation is able to induce long-term remissions in angioimmunoblastic T-cell lymphoma: a retrospective study from the lymphoma working party of the European group for blood and marrow transplantation. (19620487)
2009
22
Complete response of relapsed angioimmunoblastic T-cell lymphoma following therapy with bevacizumab. (18245132)
2008
23
Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials. (18292286)
2008
24
Complete remission induced by thalidomide in a case of angioimmunoblastic T-cell lymphoma refractory to autologous stem cell transplantation. (18661402)
2008
25
Epstein-Barr virus-positivity in tumor has no correlation with the clinical outcomes of patients with angioimmunoblastic T-cell lymphoma. (18363277)
2008
26
Angioimmunoblastic T-cell lymphoma: immune modulation as a therapeutic strategy. (17454581)
2007
27
Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience. (17378891)
2007
28
Angioimmunoblastic T-cell lymphoma: still a dismal prognosis with current treatment approaches. (17454617)
2007
29
Angioimmunoblastic T cell lymphoma: treatment experience with cyclosporine. (17454592)
2007
30
Successful treatment of refractory angioimmunoblastic T-cell lymphoma with thalidomide and dexamethasone. (16923528)
2006
31
Fulminant Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder with hemophagocytosis following autologous peripheral blood stem cell transplantation for relapsed angioimmunoblastic T-cell lymphoma. (16330097)
2006
32
Acute renal failure due to IgM-lambda glomerular thrombi and MPGN-like lesions in a patient with angioimmunoblastic T-Cell lymphoma. (16797380)
2006
33
Angioimmunoblastic T-cell lymphoma: a relatively common type of T-cell lymphoma in SjAPgren's syndrome. (16396711)
2005
34
Toxic epidermal necrolysis secondary to angioimmunoblastic T-cell lymphoma. (16008654)
2005
35
Pathology and clinical features of angioimmunoblastic T-cell lymphoma after successful treatment with thalidomide. (15744336)
2005
36
Epstein-Barr virus load correlating with clinical manifestation and treatment response in a patient with angioimmunoblastic T-cell lymphoma. (15259909)
2004
37
Successful rituximab treatment of an EBV-related lymphoproliferative disease arising after autologous transplantation for angioimmunoblastic T-cell lymphoma. (12522456)
2002
38
Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia-type T-cell lymphoma with fludarabine. (11408715)
2001
39
Analysis of T-cell subpopulations in T-cell non-Hodgkin's lymphoma of angioimmunoblastic lymphadenopathy with dysproteinemia type by single target gene amplification of T cell receptor- beta gene rearrangements. (11337383)
2001
40
Seropositive rheumatoid arthritis with dermatomyositis sine myositis, angioimmunoblastic lymphadenopathy with dysproteinemia-type T cell lymphoma, and B cell lymphoma of the oropharynx. (10782842)
2000
41
Cell dynamics and expression of tumor necrosis factor (TNF)-alpha, interleukin-6, and TNF receptors in angioimmunoblastic lymphadenopathy-type T cell lymphoma. (10716912)
2000
42
Treatment of angioimmunoblastic T-cell lymphoma with cyclosporine. (9261530)
1997
43
Simultaneous occurrence of metastatic tonsillar squamous cell carcinoma and angioimmunoblastic T-cell lymphoma in a cervical lymph node. (9231099)
1997
44
Angioimmunoblastic T-cell lymphoma (angioimmunoblastic lymphadenopathy with dysproteinemia [AILD]-type T-cell lymphoma) followed by Hodgkin's disease associated with Epstein-Barr virus. (8808302)
1995
45
Patterns of cytokine gene expression in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. (7742548)
1995
46
Detection of aberrant clones in nearly all cases of angioimmunoblastic lymphadenopathy with dysproteinemia-type T-cell lymphoma by combined interphase and metaphase cytogenetics. (7919378)
1994
47
Pathogenic significance of interleukin-6 in angioimmunoblastic lymphadenopathy-type T-cell lymphoma. (8432509)
1993
48
Detection of Epstein-Barr virus DNA and EBV-determined nuclear antigen in angioimmunoblastic lymphadenopathy with dysproteinemia type T cell lymphoma. (8183733)
1993
49
Expression of human recombination activating genes (RAG-1 and RAG-2) in angioimmunoblastic lymphadenopathy and anaplastic large cell lymphoma of T-type. (8518181)
1993
50
Peripheral T-cell lymphoma of AILD (angioimmunoblastic lymphadenopathy with dysproteinemia) type involving gastrointestinal tract. A morphologic, phenotypic and genotypic study. (1314007)
1992

Genetic Variations for Angioimmunoblastic T-Cell Lymphoma

Expression for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

Search GEO for disease gene expression data for Angioimmunoblastic T-Cell Lymphoma.

Pathways for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

Sources:
4Cell Signaling Technology, 54Reactome, 30KEGG
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Pathways related to Angioimmunoblastic T-Cell Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0ENG, TEK, VEGFC
2
Hide members
9.8TRBC1, PDCD1LG2, PDCD1
39.8GZMB, MET, MAF, BCL6
4
Hide members
9.7TRBC1, PDCD1LG2, PDCD1, ICOS

Compounds for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank
See all sources

Compounds related to Angioimmunoblastic T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1estrogen4510.3BCL6
2serine4510.1TEK, GZMB
3p0024510.0ENG, TEK, MET
4ribonucleic acid459.9GZMB, MME, TEK, VEGFC, MET
512-o-tetradecanoylphorbol 13-acetate459.9MME, MET, CSTA, GZMB, BCL6
6matrigel459.8CSTA, MET, VEGFC, MME, TEK, ENG
7vegf459.7TEK, MME, VEGFC, MET, GZMB, ENG
8oxygen45 2410.6TEK, ENG, MME, VEGFC, MET, GZMB
9cysteine459.5TEK, ENG, GZMB, CSTA, MET, MME
10doxorubicin45 50 1111.5MET, MME, ENG, BCL6
11paraffin459.4GZMB, MET, VEGFC, MME, TEK, BCL6
12tyrosine459.2BCL6, GZMB, ENG, TEK, MME, VEGFC

GO Terms for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Angioimmunoblastic T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1germinal center formationGO:00246710.1BCL6, CXCL13
2cell-cell adhesionGO:0163379.9ICOS, CSTA, TEK
3T cell costimulationGO:0312959.8TRBC1, PDCD1LG2, PDCD1, ICOS
4immune responseGO:0069559.7CXCL13, TRBC1, PDCD1LG2, ICOS
5regulation of immune responseGO:0507769.5BCL6, CD200, TRBC1

Products for genes affiliated with Angioimmunoblastic T-Cell Lymphoma

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Sources for Angioimmunoblastic T-Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet