MCID: ANG016
MIFTS: 44

Angiokeratoma malady

Cancer diseases, Skin diseases categories
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Summaries for Angiokeratoma

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Angiokeratoma is a benign cutaneous lesion of capillaries, resulting in small marks of red to blue color... more...

MalaCards: Angiokeratoma, also known as angiokeratoma of skin, is related to fabry disease and fucosidosis. An important gene associated with Angiokeratoma is NAGA (N-acetylgalactosaminidase, alpha-), and among its related pathways are Glycosphingolipid biosynthesis - globo series and Other glycan degradation. The compounds glycolipid and glycerol have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and skeletal muscle, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Angiokeratoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

angiokeratoma 8 10 45 62
angiokeratoma of skin 8 62
cutaneous angiokeratoma 8
skin angiokeratoma 8


External Ids:

Disease Ontology8 DOID:479
MeSH35 D000794
SNOMED-CT58 26810009, 254788004
NCIt40 C2874

Related Diseases for Angiokeratoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Angiokeratoma:



Diseases related to angiokeratoma

Symptoms for Angiokeratoma

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Drugs & Therapeutics for Angiokeratoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Angiokeratoma

Genetic Tests for Angiokeratoma

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Anatomical Context for Angiokeratoma

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33MalaCards
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MalaCards organs/tissues related to Angiokeratoma:

33
Skin, Tongue, Skeletal muscle, Kidney, Breast, Endothelial

Animal Models for Angiokeratoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Angiokeratoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.8AGA, GLA, MANBA
2MP:00053708.5AGA, GLA, MANBA

Publications for Angiokeratoma

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52PubMed
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Articles related to Angiokeratoma:

(show top 50)    (show all 304)
idTitleAuthorsYear
1
Angiokeratoma corporis diffusum in a patient with Hodgkin lymphoma: a new paraneoplastic skin manifestation? (23278357)
2013
2
Enzyme replacement therapy in two Japanese siblings with Fabry disease, and its effectiveness on angiokeratoma and neuropathic pain. (23906479)
2013
3
Angiokeratoma presenting as a melanoma: a case report. (23697732)
2013
4
Angiokeratoma - When is a few too many? (24104692)
2013
5
Solitary angiokeratoma on palms and soles: a clinicopathological analysis of 21 cases. (23734792)
2013
6
Unilateral angiokeratoma of fordyce. (22917529)
2013
7
Concurrent diagnosis of vulvar angiokeratoma with recurrent squamous cell carcinoma after radical vulvectomy and radiation therapy. (24371626)
2012
8
Myoclonus and angiokeratomas in adult galactosialidosis. (21312277)
2011
9
Angiokeratoma of the vulva. (22053688)
2011
10
Report of two angiokeratoma of Fordyce cases treated with a 1064 nm long-pulsed Nd:YAG laser. (19439000)
2009
11
Case study: the surgical management of angiokeratoma resulting from radiotherapy for penile cancer. (19468654)
2009
12
Angiokeratoma of clitoris: a rare lesion in an adolescent girl. (18291515)
2008
13
Treatment of angiokeratoma of Fordyce with pulsed dye laser. (16970695)
2006
14
Solitary angiokeratoma of the tongue. (16519775)
2006
15
Angiokeratoma Fordyce of the glans penis: combined treatment with erbium: YAG and 532 nm KTP (frequency doubled neodynium: YAG) laser. (15729872)
2004
16
Linear acral pseudolymphomatous angiokeratoma of children (APACHE): further evidence that APACHE is a cutaneous pseudolymphoma. (12582375)
2003
17
Vulvar angiokeratoma following radical hysterectomy and radiotherapy. (12027822)
2002
18
Comments on angiokeratoma of the tongue. (17656958)
2002
19
Severe predominantly acral variant of angiokeratoma of Mibelli: response to long-pulse Nd:YAG (1064 nm) laser treatment. (11606931)
2001
20
Angiokeratoma circumscriptum naeviforme: rare presentation on the neck. (11903167)
2001
21
Angiokeratoma of tongue. (17664774)
2001
22
Angiokeratoma of the oral cavity and scrotum. (10721665)
2000
23
Idiopathic angiokeratoma corporis diffusum. (9499615)
1997
24
Laser treatment of recurrent vulvar angiokeratoma associated with Noonan syndrome. (8677117)
1996
25
Angiokeratoma corporis diffusum with glycopeptiduria due to deficient lysosomal alpha-N-acetylgalactosaminidase activity. Clinical, morphologic, and biochemical studies. (8466216)
1993
26
Transepidermal elimination of thrombi in three cases of thrombotic angiokeratoma: an incidental histopathologic finding of angiokeratoma. (1791241)
1991
27
Biochemical and clinical analysis of accumulated glycolipids in symptomatic heterozygotes of angiokeratoma corporis diffusum (Fabry's disease) in comparison with hemizygotes. (2157788)
1990
28
Anderson-Fabry disease (angiokeratoma corporis diffusum universale). (2123167)
1990
29
Angiokeratoma of the vulva: diagnosis and review of the literature. (2657519)
1989
30
Ultrastructure of angiokeratoma vulvae. (2449019)
1988
31
Angiokeratoma circumscriptum of the index finger in a child. (7465672)
1981
32
Diffuse angiokeratoma (Fabry's disease): Case report. (817232)
1976
33
A case of angiokeratoma corporis circumscriptum neviforme. (811697)
1975
34
Angiokeratoma corporis diffusum with alpha-L-fucosidase deficiency. (4634000)
1973
35
Angiokeratoma "Circumscriptum". (4639261)
1972
36
Angiokeratoma of Mibelli with necrosis of the fingertips. (4635805)
1972
37
Angiokeratoma of the vulva. (5479313)
1970
38
Linkage relationships of the angiokeratoma (Fabry) locus. (5307232)
1969
39
Radiation angiokeratoma following grenz radiation. (5822372)
1969
40
Angiokeratoma of Mibelli: a family with nodular lesions of the legs. (5708572)
1968
41
Angiokeratoma corporis diffusum. Some clinical aspects. (5642987)
1968
42
Angiokeratoma corporis diffusum--Fabry's disease. (5592081)
1967
43
Angiokeratoma corporis diffusum. (5960367)
1966
44
Thrombosed angiokeratoma simulating malignant melanoma. (5910881)
1966
45
The ocular manifestations of hereditary dystopic lipidosis (angiokeratoma corporis diffusum universale). (13990468)
1963
46
Angiokeratoma corporis diffusum. (13781480)
1960
47
Angiokeratoma corporis diffusum. (13584689)
1958
48
Histological investigation of the skin in angiokeratoma corporis diffusum in particular with regard to the associated disturbance of phosphatid metabolism. (13219963)
1954
49
Angiomas of the scrotum (angiokeratoma, Fordyce); compilation of cases and discussion of nomenclature. (20277301)
1946
50
Angiokeratoma, with Bony Changes. (19977542)
1914

Variations for Angiokeratoma

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Expression for genes affiliated with Angiokeratoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiokeratoma

Search GEO for disease gene expression data for Angiokeratoma.

Pathways for genes affiliated with Angiokeratoma

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50PathCards, 30KEGG
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Pathways related to Angiokeratoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4GLA, NAGA
28.6FUCA1, MANBA, AGA
37.5AGA, GLA, MANBA, NAGA, FUCA1

Compounds for genes affiliated with Angiokeratoma

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45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Angiokeratoma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1glycolipid459.6NAGA, GLA
2glycerol45 24 1111.4GLA, NAGA
31-deoxynojirimycin61 45 1111.3GLA, FUCA1
4glutaraldehyde459.2GLA, FUCA1
5ganglioside459.2GLA, FUCA1
6polysaccharide459.1MANBA, FUCA1
7n-acetylglucosamine459.0AGA, NAGA, FUCA1
8sucrose45 24 1110.9GLA, FUCA1
9carbon458.8GLA, NAGA, FUCA1
10mannose 6-phosphate45 249.8AGA, GLA, FUCA1
11mannose458.8FUCA1, MANBA, GLA
12methionine458.7GLA, FUCA1
13Water248.7GLA, NAGA, FUCA1
14glucose458.6FUCA1, NAGA, GLA

GO Terms for genes affiliated with Angiokeratoma

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16Gene Ontology
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Cellular components related to Angiokeratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057647.5AGA, GLA, MANBA, NAGA, FUCA1

Biological processes related to Angiokeratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oligosaccharide metabolic processGO:0093119.4GLA, NAGA
2glycosylceramide catabolic processGO:0464779.1GLA, NAGA
3glycoside catabolic processGO:0161398.5GLA, NAGA, FUCA1

Molecular functions related to Angiokeratoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alpha-galactosidase activityGO:0045579.4GLA, NAGA

Products for genes affiliated with Angiokeratoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angiokeratoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet