MCID: ANG016
MIFTS: 40

Angiokeratoma malady

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Angiokeratoma

Aliases & Descriptions for Angiokeratoma:

Name: Angiokeratoma 12 29 52 42 14 69
Angiokeratoma of Skin 12 69
Cutaneous Angiokeratoma 12
Skin Angiokeratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:479
MeSH 42 D000794
NCIt 47 C2874 C4488
SNOMED-CT 64 254788004 26810009

Summaries for Angiokeratoma

MalaCards based summary : Angiokeratoma, also known as angiokeratoma of skin, is related to fucosidosis and mannosidosis. An important gene associated with Angiokeratoma is NAGA (Alpha-N-Acetylgalactosaminidase), and among its related pathways/superpathways are Lysosome and Globo Sphingolipid Metabolism. Affiliated tissues include skin, tongue and endothelial, and related phenotypes are Decreased viability in esophageal squamous lineage and liver/biliary system

Wikipedia : 71 Angiokeratoma is a benign cutaneous lesion of capillaries, resulting in small marks of red to blue color... more...

Related Diseases for Angiokeratoma

Diseases related to Angiokeratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Related Disease Score Top Affiliating Genes
1 fucosidosis 31.7 CTSA FUCA1 NAGA
2 mannosidosis 28.9 CTSA FUCA1 GLA MANBA
3 angiokeratoma of fordyce 12.0
4 angiokeratoma circumscriptum 12.0
5 vulvar angiokeratoma 12.0
6 fabry disease 11.9
7 angiokeratoma of mibelli 11.9
8 angiokeratoma corporis diffusum with arteriovenous fistulas 11.8
9 galactosialidosis 11.3
10 kanzaki disease 11.2
11 schindler disease 10.9
12 mannosidosis, beta 10.8
13 schindler disease, type i 10.8
14 cobb syndrome 10.8
15 mccallum macadam johnston syndrome 10.8
16 charge syndrome 9.9 GLA MANBA
17 malignant fibrous histiocytoma of bone 9.9 CTSA NAGA
18 nasopharyngeal carcinoma 2 9.9 CTSA NAGA
19 melanoma 9.9
20 retinitis pigmentosa 29 9.9 CTSA NAGA
21 seizures, benign familial infantile, 1 9.9 CTSA MANBA
22 purpura 9.9 CTSA NAGA
23 hemangioma 9.9
24 dysostosis 9.9 CTSA GLA
25 epileptic encephalopathy, early infantile, 9 9.9 FUCA1 GLA NAGA
26 megakaryocytic leukemia 9.8 CTSA MANBA NAGA
27 hyperinsulinemic hypoglycemia, familial, 4 9.8 CTSA MANBA NAGA
28 myopia 23, autosomal recessive 9.7 CTSA GLA
29 intracranial hypotension 9.7 GLA MANBA NAGA PROX1
30 granuloma annulare 9.7
31 penile cancer 9.7
32 varicocele 9.7
33 lymphangioma 9.7
34 necrobiosis lipoidica 9.7
35 verrucous hemangioma 9.7
36 cutaneous pseudolymphoma 9.7
37 myocardial infarction 9.6
38 hodgkin lymphoma 9.6
39 aspartylglucosaminuria 9.6
40 kaposi sarcoma 9.6
41 blue rubber bleb nevus 9.6
42 arteriovenous fistula 9.6
43 lymphedema 9.6
44 lymphoma 9.6
45 sarcoma 9.6
46 mucopolysaccharidosis 9.6
47 diarrhea 9.6
48 squamous cell carcinoma 9.6
49 vaginitis 9.6
50 papilloma 9.6

Graphical network of the top 20 diseases related to Angiokeratoma:



Diseases related to Angiokeratoma

Symptoms & Phenotypes for Angiokeratoma

GenomeRNAi Phenotypes related to Angiokeratoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.02 CTSA GLA MANBA NAGA PROX1

MGI Mouse Phenotypes related to Angiokeratoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 CTSA GLA MANBA PROX1

Drugs & Therapeutics for Angiokeratoma

Interventional clinical trials:


id Name Status NCT ID Phase
1 Fabry Disease Registry Recruiting NCT00196742
2 Fabry's Disease and Pregnancy (PREFAB) Enrolling by invitation NCT02582294
3 Enzyme Replacement Therapy in Fabry Disease Terminated NCT00149318

Search NIH Clinical Center for Angiokeratoma

Cochrane evidence based reviews: angiokeratoma

Genetic Tests for Angiokeratoma

Genetic tests related to Angiokeratoma:

id Genetic test Affiliating Genes
1 Angiokeratoma 29

Anatomical Context for Angiokeratoma

MalaCards organs/tissues related to Angiokeratoma:

39
Skin, Tongue, Endothelial, Kidney, Breast, Skeletal Muscle, Cervix

Publications for Angiokeratoma

Articles related to Angiokeratoma:

(show top 50) (show all 354)
id Title Authors Year
1
Angiokeratoma of Tongue. ( 28060116 )
2017
2
Acral pseudolymphomatous angiokeratoma of children with rainbow pattern: A mimicker of Kaposi sarcoma. ( 28087020 )
2017
3
Solitary angiokeratoma with Meyerson phenomenon. ( 28087017 )
2017
4
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. ( 26736060 )
2016
5
Angiokeratoma corporis diffusum (Fabry disease) - A case report. ( 27727956 )
2016
6
Bleeding Angiokeratomas in Fabry Disease Treated With Argon Plasma Coagulation. ( 27060427 )
2016
7
Solitary Angiokeratoma Presenting as Cutaneous Horn over the Prepuce: A Rare Appearance. ( 27057048 )
2016
8
Acral pseudolymphomatous angiokeratoma of children (APACHE)-like eruption in adult identical twins. ( 27663149 )
2016
9
Radiation-induced Vulvar Angiokeratoma Along with Other Late Radiation Toxicities after Carcinoma Cervix: A Rare Case Report. ( 27057045 )
2016
10
Angiokeratoma of the gluteal region in old age. ( 27694066 )
2016
11
Eruptive angiokeratomas and porokeratosis in the setting of sclerodermatous graft-vs.-host disease. ( 26957361 )
2016
12
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. ( 27511129 )
2016
13
Efficacy of 595nm pulsed dye laser therapy for Mibelli angiokeratoma. ( 25549813 )
2015
14
Pigmented Spitz nevus simulating a solitary angiokeratoma. ( 25773434 )
2015
15
A rare case of angiokeratoma in a 8-month-old boy. ( 25678595 )
2015
16
Linear acral pseudolymphomatous angiokeratoma of children with associated nail dystrophy. ( 26436972 )
2015
17
Solitary Angiokeratoma: Report of Two Uncommon Cases. ( 26155544 )
2015
18
Angiokeratoma corporis diffusum. ( 25691205 )
2015
19
An Extreme Case of Fordyce Angiokeratoma. ( 26099899 )
2015
20
Angiokeratoma of Fordyce response to long pulsed Nd:YAG laser treatment. ( 26531316 )
2015
21
Multiple giant angiokeratoma of Fordyce on the shaft of the penis masquerading as keratoacanthoma. ( 26312700 )
2015
22
In vivo characterization of solitary angiokeratoma by reflectance confocal microscopy and high definition optical coherence tomography. ( 25500039 )
2015
23
Thrombotic phenomena in angiokeratoma can evolve into spontaneous involution of the lesions: a report of two cases. ( 26395775 )
2015
24
Multicentric study on the diagnosis of Fabry's disease using angiokeratoma biopsy registries. ( 25778427 )
2015
25
Pulsed dye laser versus long pulsed Nd:YAG laser in the treatment of angiokeratoma of Fordyce: A randomized, comparative, observer-blinded study. ( 26371766 )
2015
26
Subungual Angiokeratoma Presenting as a Longitudinal Pigmented Band in the Nail. ( 25721145 )
2015
27
Unilateral angiokeratoma of vulva: a rare clinic entity. ( 26259393 )
2015
28
Familial angiokeratoma corporis diffusum without identified enzyme defect. ( 25566897 )
2015
29
Treatment of angiokeratoma of Mibelli alone or in combination with pulsed dye laser and long-pulsed Nd: YAG laser. ( 24911941 )
2014
30
Eyelid angiokeratoma. ( 25100920 )
2014
31
Expression of WT-1 by the Vascular Component of Acral Pseudolymphomatous Angiokeratoma of Children. ( 25376760 )
2014
32
Angiokeratoma of vulva mimicking genital warts. ( 25404845 )
2014
33
Angiokeratoma circumscriptum in a young male. ( 24470669 )
2014
34
Angiokeratoma circumscriptum neviforme: An entity, few and far between. ( 25396132 )
2014
35
Angiokeratoma of the nasal vestibule: a case report. ( 25547753 )
2014
36
Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. ( 25368837 )
2014
37
Unusual presentation of angiokeratoma in a cirrhotic patient. ( 24470684 )
2014
38
Uncertain Diagnosis of Fabry Disease in Patients with Neuropathic Pain, Angiokeratoma or Cornea Verticillata: Consensus on the Approach to Diagnosis and Follow-Up. ( 25224312 )
2014
39
Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? ( 25593797 )
2014
40
Papular pseudolymphoma of adults as a variant of acral pseudolymphomatous angiokeratoma of children (APACHE). ( 24628800 )
2014
41
A very rare case of vaginal angiokeratoma. ( 24984549 )
2014
42
Solitary angiokeratoma of tongue: a rare entity clinically mistaken as a malignant tumor. ( 25118768 )
2014
43
Angiokeratoma circumscriptum: dilemma in diagnosis. ( 24943793 )
2014
44
Lymphangioma circumscriptum, angiokeratoma, or superficial vascular ectasia with epithelial hyperplasia? ( 24491964 )
2014
45
Late onset palmar angiokeratoma circumscriptum: An unusual presentation. ( 25165655 )
2014
46
A case of solitary angiokeratoma successfully treated with a 1064-nm long-pulsed Nd:YAG laser. ( 25260142 )
2014
47
Unusual papillary lesion of the ventral tongue: case report of solitary angiokeratoma of the oral cavity. ( 23767401 )
2013
48
Angiokeratoma corporis diffusum in the absence of metabolic disorders: a case report and mini-review of the published work. ( 23682989 )
2013
49
Fabry disease and the clinical spectrum of angiokeratomas. ( 22975414 )
2013
50
Angiokeratoma presenting as a melanoma: a case report. ( 23697732 )
2013

Variations for Angiokeratoma

Expression for Angiokeratoma

Search GEO for disease gene expression data for Angiokeratoma.

Pathways for Angiokeratoma

Pathways related to Angiokeratoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.11 CTSA FUCA1 GLA MANBA NAGA
2
Show member pathways
10.72 GLA NAGA
3 10.21 FUCA1 MANBA

GO Terms for Angiokeratoma

Cellular components related to Angiokeratoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.35 CTSA FUCA1 GLA MANBA NAGA
2 azurophil granule lumen GO:0035578 9.33 CTSA FUCA1 GLA
3 lysosomal lumen GO:0043202 8.92 CTSA FUCA1 GLA MANBA

Biological processes related to Angiokeratoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.56 FUCA1 GLA MANBA NAGA
2 neutrophil degranulation GO:0043312 9.46 CTSA FUCA1 GLA MANBA
3 glycosphingolipid metabolic process GO:0006687 9.32 CTSA GLA
4 carbohydrate metabolic process GO:0005975 9.26 FUCA1 GLA MANBA NAGA
5 glycoside catabolic process GO:0016139 8.8 FUCA1 GLA NAGA

Molecular functions related to Angiokeratoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.55 CTSA FUCA1 GLA MANBA NAGA
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.26 GLA NAGA
3 alpha-galactosidase activity GO:0004557 8.96 GLA NAGA
4 hydrolase activity, acting on glycosyl bonds GO:0016798 8.92 FUCA1 GLA MANBA NAGA

Sources for Angiokeratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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