MCID: ANG016
MIFTS: 38

Angiokeratoma

Categories: Skin diseases, Cancer diseases

Aliases & Classifications for Angiokeratoma

MalaCards integrated aliases for Angiokeratoma:

Name: Angiokeratoma 12 28 51 41 14 69
Angiokeratoma of Skin 12 69
Cutaneous Angiokeratoma 12
Skin Angiokeratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:479
MeSH 41 D000794
NCIt 46 C2874 C4488
SNOMED-CT 64 254788004 26810009

Summaries for Angiokeratoma

MalaCards based summary : Angiokeratoma, also known as angiokeratoma of skin, is related to fabry disease and fucosidosis. An important gene associated with Angiokeratoma is NAGA (Alpha-N-Acetylgalactosaminidase), and among its related pathways/superpathways are Lysosome and Globo Sphingolipid Metabolism. Affiliated tissues include skin, tongue and endothelial.

Wikipedia : 72 Angiokeratoma is a benign cutaneous lesion of capillaries, resulting in small marks of red to blue color... more...

Related Diseases for Angiokeratoma

Diseases related to Angiokeratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 fabry disease 32.4 FUCA1 GLA NAGA
2 fucosidosis 31.3 CTSA FUCA1 NAGA
3 mannosidosis, beta a, lysosomal 31.0 CTSA MANBA NAGA
4 mannosidosis 29.7 MANBA NAGA
5 aspartylglucosaminuria 29.0 CTSA NAGA
6 angiokeratoma of fordyce 12.2
7 angiokeratoma circumscriptum 12.1
8 vulvar angiokeratoma 12.1
9 angiokeratoma of mibelli 12.0
10 angiokeratoma corporis diffusum with arteriovenous fistulas 11.9
11 kanzaki disease 11.5
12 galactosialidosis 11.4
13 mccallum macadam johnston syndrome 11.2
14 cobb syndrome 11.0
15 schindler disease 11.0
16 schindler disease, type i 10.9
17 melanoma 10.0
18 hemangioma 10.0
19 aging 9.9
20 episodic pain syndrome, familial, 1 9.9
21 varicocele 9.9
22 granuloma annulare 9.8
23 penile cancer 9.8
24 lymphangioma 9.8
25 necrobiosis lipoidica 9.8
26 verrucous hemangioma 9.8
27 cutaneous pseudolymphoma 9.8
28 gangliosidosis gm2 9.7 CTSA NAGA
29 mannosidosis, alpha b, lysosomal 9.7 CTSA MANBA
30 glycoproteinosis 9.7 CTSA NAGA
31 blue rubber bleb nevus 9.7
32 cerebral cavernous malformations 9.7
33 kaposi sarcoma 9.7
34 klippel-trenaunay-weber syndrome 9.7
35 noonan syndrome 1 9.7
36 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.7
37 lymphoma, hodgkin, classic 9.7
38 neuraminidase deficiency 9.7
39 angioma serpiginosum, x-linked 9.7
40 myocardial infarction 9.7
41 mucopolysaccharidosis-plus syndrome 9.7
42 arteriovenous fistula 9.7
43 lymphedema 9.7
44 lymphoma 9.7
45 sarcoma 9.7
46 anogenital venereal wart 9.7
47 diarrhea 9.7
48 squamous cell carcinoma 9.7
49 vaginitis 9.7
50 papilloma 9.7

Graphical network of the top 20 diseases related to Angiokeratoma:



Diseases related to Angiokeratoma

Symptoms & Phenotypes for Angiokeratoma

Drugs & Therapeutics for Angiokeratoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fabry's Disease and Pregnancy (PREFAB) Recruiting NCT02582294
2 Fabry Disease Registry Recruiting NCT00196742
3 Enzyme Replacement Therapy in Fabry Disease Terminated NCT00149318

Search NIH Clinical Center for Angiokeratoma

Cochrane evidence based reviews: angiokeratoma

Genetic Tests for Angiokeratoma

Genetic tests related to Angiokeratoma:

# Genetic test Affiliating Genes
1 Angiokeratoma 28

Anatomical Context for Angiokeratoma

MalaCards organs/tissues related to Angiokeratoma:

38
Skin, Tongue, Endothelial, Cervix, Skeletal Muscle, Breast, Kidney

Publications for Angiokeratoma

Articles related to Angiokeratoma:

(show top 50) (show all 361)
# Title Authors Year
1
A subungual angiokeratoma with characteristic clinical and dermoscopic features. ( 29376508 )
2018
2
Unilateral angiokeratoma of vulva: a rare clinic entity. ( 28976126 )
2017
3
Rare Giant Angiokeratoma of the Vulva: A Case Report. ( 28418344 )
2017
4
Acral angiokeratoma-like pseudolymphoma in a middle-aged woman. ( 28675468 )
2017
5
Solitary angiokeratoma presenting as cutaneous horn. ( 28406536 )
2017
6
Angiokeratoma of the Glans Penis. ( 29139361 )
2017
7
Solitary angiokeratoma with Meyerson phenomenon. ( 28087017 )
2017
8
Unilateral angiokeratoma of the scrotum (Fordyce's type) associated with a contralateral varicocele. ( 28540880 )
2017
9
Acral pseudolymphomatous angiokeratoma of children with rainbow pattern: A mimicker of Kaposi sarcoma. ( 28087020 )
2017
10
Angiokeratoma of Tongue. ( 28060116 )
2017
11
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. ( 27511129 )
2016
12
Angiokeratoma corporis diffusum (Fabry disease) - A case report. ( 27727956 )
2016
13
Acral pseudolymphomatous angiokeratoma of children (APACHE)-like eruption in adult identical twins. ( 27663149 )
2016
14
Solitary Angiokeratoma Presenting as Cutaneous Horn over the Prepuce: A Rare Appearance. ( 27057048 )
2016
15
Angiokeratoma of the gluteal region in old age. ( 27694066 )
2016
16
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. ( 26736060 )
2016
17
Eruptive angiokeratomas and porokeratosis in the setting of sclerodermatous graft-vs.-host disease. ( 26957361 )
2016
18
Bleeding Angiokeratomas in Fabry Disease Treated With Argon Plasma Coagulation. ( 27060427 )
2016
19
Radiation-induced Vulvar Angiokeratoma Along with Other Late Radiation Toxicities after Carcinoma Cervix: A Rare Case Report. ( 27057045 )
2016
20
Angiokeratoma of Fordyce response to long pulsed Nd:YAG laser treatment. ( 26531316 )
2015
21
Subungual Angiokeratoma Presenting as a Longitudinal Pigmented Band in the Nail. ( 25721145 )
2015
22
An Extreme Case of Fordyce Angiokeratoma. ( 26099899 )
2015
23
Angiokeratoma corporis diffusum. ( 25691205 )
2015
24
Solitary Angiokeratoma: Report of Two Uncommon Cases. ( 26155544 )
2015
25
A rare case of angiokeratoma in a 8-month-old boy. ( 25678595 )
2015
26
Linear acral pseudolymphomatous angiokeratoma of children with associated nail dystrophy. ( 26436972 )
2015
27
Pigmented Spitz nevus simulating a solitary angiokeratoma. ( 25773434 )
2015
28
Multicentric study on the diagnosis of Fabry's disease using angiokeratoma biopsy registries. ( 25778427 )
2015
29
Familial angiokeratoma corporis diffusum without identified enzyme defect. ( 25566897 )
2015
30
Pulsed dye laser versus long pulsed Nd:YAG laser in the treatment of angiokeratoma of Fordyce: A randomized, comparative, observer-blinded study. ( 26371766 )
2015
31
Multiple giant angiokeratoma of Fordyce on the shaft of the penis masquerading as keratoacanthoma. ( 26312700 )
2015
32
In vivo characterization of solitary angiokeratoma by reflectance confocal microscopy and high definition optical coherence tomography. ( 25500039 )
2015
33
Efficacy of 595nm pulsed dye laser therapy for Mibelli angiokeratoma. ( 25549813 )
2015
34
Thrombotic phenomena in angiokeratoma can evolve into spontaneous involution of the lesions: a report of two cases. ( 26395775 )
2015
35
Unilateral angiokeratoma of vulva: a rare clinic entity. ( 26259393 )
2015
36
Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. ( 25368837 )
2014
37
Treatment of angiokeratoma of Mibelli alone or in combination with pulsed dye laser and long-pulsed Nd: YAG laser. ( 24911941 )
2014
38
Eyelid angiokeratoma. ( 25100920 )
2014
39
Uncertain Diagnosis of Fabry Disease in Patients with Neuropathic Pain, Angiokeratoma or Cornea Verticillata: Consensus on the Approach to Diagnosis and Follow-Up. ( 25224312 )
2014
40
Late onset palmar angiokeratoma circumscriptum: An unusual presentation. ( 25165655 )
2014
41
Angiokeratoma of vulva mimicking genital warts. ( 25404845 )
2014
42
Expression of WT-1 by the Vascular Component of Acral Pseudolymphomatous Angiokeratoma of Children. ( 25376760 )
2014
43
Solitary angiokeratoma of tongue: a rare entity clinically mistaken as a malignant tumor. ( 25118768 )
2014
44
Unusual presentation of angiokeratoma in a cirrhotic patient. ( 24470684 )
2014
45
Lymphangioma circumscriptum, angiokeratoma, or superficial vascular ectasia with epithelial hyperplasia? ( 24491964 )
2014
46
Angiokeratoma circumscriptum neviforme: An entity, few and far between. ( 25396132 )
2014
47
Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? ( 25593797 )
2014
48
A very rare case of vaginal angiokeratoma. ( 24984549 )
2014
49
A case of solitary angiokeratoma successfully treated with a 1064-nm long-pulsed Nd:YAG laser. ( 25260142 )
2014
50
Papular pseudolymphoma of adults as a variant of acral pseudolymphomatous angiokeratoma of children (APACHE). ( 24628800 )
2014

Variations for Angiokeratoma

Expression for Angiokeratoma

Search GEO for disease gene expression data for Angiokeratoma.

Pathways for Angiokeratoma

Pathways related to Angiokeratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 CTSA FUCA1 GLA MANBA NAGA
2
Show member pathways
10.72 GLA NAGA
3 10.21 FUCA1 MANBA

GO Terms for Angiokeratoma

Cellular components related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 9.33 CTSA FUCA1 GLA
2 lysosomal lumen GO:0043202 9.26 CTSA FUCA1 GLA MANBA
3 lysosome GO:0005764 9.02 CTSA FUCA1 GLA MANBA NAGA

Biological processes related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.67 FUCA1 GLA MANBA NAGA
2 neutrophil degranulation GO:0043312 9.62 CTSA FUCA1 GLA MANBA
3 glycosphingolipid metabolic process GO:0006687 9.43 CTSA GLA
4 oligosaccharide metabolic process GO:0009311 9.4 GLA NAGA
5 glycosylceramide catabolic process GO:0046477 9.26 GLA NAGA
6 carbohydrate metabolic process GO:0005975 9.26 FUCA1 GLA MANBA NAGA
7 glycolipid catabolic process GO:0019377 9.16 FUCA1 NAGA
8 glycoside catabolic process GO:0016139 8.8 FUCA1 GLA NAGA

Molecular functions related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.55 CTSA FUCA1 GLA MANBA NAGA
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.26 GLA NAGA
3 alpha-galactosidase activity GO:0004557 8.96 GLA NAGA
4 hydrolase activity, acting on glycosyl bonds GO:0016798 8.92 FUCA1 GLA MANBA NAGA

Sources for Angiokeratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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