MCID: ANG037
MIFTS: 37

Angiomatosis malady

Summaries for Angiomatosis

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Von Hippel-Lindau disease (VHL) is a rare, genetic multi-system disorder characterized by the abnormal growth of tumors in certain parts of the body. The tumors of the central nervous system (CNS) are benign and are comprised of a nest of blood vessels and are called hemangioblastomas. Hemangioblastomas may develop in the brain, the retina of the eyes, and other areas of the nervous system. Other types of tumors develop in the adrenal glands, the kidneys, or the pancreas. Symptoms of VHL vary among patients and depend on the size and location of the tumors. Symptoms may include headaches, problems with balance and walking, dizziness, weakness of the limbs, vision problems, and high blood pressure. Cysts (fluid-filled sacs) and/or tumors (benign or cancerous) may develop around the hemangioblastomas and cause the symptoms listed above. Individuals with VHL are also at a higher risk than normal for certain types of cancer, especially kidney cancer.

MalaCards: Angiomatosis is related to von hippel-lindau disease and tuberous sclerosis. An important gene associated with Angiomatosis is VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase). The compounds paraffin and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Wikipedia:64 Angiomatosis is a non-neoplastic condition presenting with little knots of capillaries in various... more...

Aliases & Classifications for Angiomatosis

Sources:
44NINDS, 45Novoseek, 61UMLS
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Aliases & Descriptions:

angiomatosis 44 45 61


Related Diseases for Angiomatosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Angiomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1von hippel-lindau disease30.4TSC2, VHL
2tuberous sclerosis30.0TSC2, CCL26, VHL
3hemangioendothelioma29.7CD34
4tuberous sclerosis complex29.7TSC2
5neurofibromatosis29.7TSC2, VHL
6adenoma29.7PLAG1, H19, VHL
7pheochromocytoma29.7DLK1, H19, VHL
8acute leukemia29.7TSC2, CD34
9adenocarcinoma29.7VHL, CCL26, H19, CD34, PLAG1, TSC2
10diffuse dermal angiomatosis10.5
11sturge-weber syndrome10.5
12weber syndrome10.4
13kaposi's sarcoma10.4
14breast angiomatosis10.4
15acquired immunodeficiency syndrome10.4
16n syndrome10.4
17cerebral angioma10.3
18cobb syndrome10.3
19sturge-weber syndrome, somatic, mosaic10.2
20thrombocytopenia10.2
21familial capillaro-venous leptomeningeal angiomatosis10.2
22angiomatosis, leptomeningeal capillary venous10.2
23bacteremia10.2
24klippel-trenaunay syndrome10.1
25atherosclerosis10.1
26angiomatosis, diffuse corticomeningeal, of divry and van bogaert10.1
27pyogenic granuloma10.1
28reactive angioendotheliomatosis10.1
29sneddon syndrome10.0
30calciphylaxis10.0
31peliosis hepatis10.0
32gorham's disease10.0
33ollier disease10.0
34angiosarcoma10.0
35von hippel–lindau disease10.0
36blue rubber bleb nevus syndrome10.0
37lymphangiomatosis10.0
38glomus tumor10.0VHL
39esophagitis10.0CCL26
40hemangioblastoma10.0VHL
41meningioma10.0CD34
42fibrosarcoma10.0CD34
43myeloid leukemia10.0CD34
44perivascular epithelioid cell tumor10.0TSC2
45neurofibroma10.0CD34
46cystadenoma10.0VHL
47vascular cancer10.0VHL, CD34
48hemangioma10.0CD34, VHL
49endometrial carcinoma10.0CD34
50lymphangioleiomyomatosis10.0TSC2

Graphical network of the top 20 diseases related to Angiomatosis:



Diseases related to angiomatosis

Clinical Features for Angiomatosis

Drugs & Therapeutics for Angiomatosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Angiomatosis

Search CenterWatch for Angiomatosis

Genetic Tests for Angiomatosis

Anatomical Context for Angiomatosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Angiomatosis:

33
Skin, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Uterus, Bone marrow, Cerebellum, Retina, Heart, Small intestine, Colon, Pancreas, Adrenal gland, Breast, B cells, Endothelial, Temporal lobe, Occipital lobe

Animal Models for Angiomatosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Angiomatosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3PLAG1, H19
2MP:00020068.7VHL, H19, CD34, TSC2
3MP:00053708.3VHL, H19, DLK1, TSC2
4MP:00053807.8TSC2, PLAG1, DLK1, H19, VHL
5MP:00053787.7TSC2, PLAG1, DLK1, H19, VHL
6MP:00053847.5VHL, H19, CD34, DLK1, TSC2

Publications for Angiomatosis

Sources:
51PubMed
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Articles related to Angiomatosis:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Bacterial sepsis resulting in severe systemic illness and euthanasia in a dog with cutaneous angiomatosis. (24082170)
2013
2
Pulmonary angiomatosis and hemangioma in common dolphins (Delphinus delphis) stranded in Canary Islands. (22467071)
2012
3
Refractory Bartonella quintana bacillary angiomatosis following chemotherapy for chronic lymphocytic leukaemia. (20947664)
2011
4
Molecular detection of Bartonella henselae for the diagnosis of cat scratch disease and bacillary angiomatosis of the conjunctiva. (21282991)
2011
5
Angiomatosis: a case report. (20717181)
2010
6
Bacillary angiomatosis in a pregnant woman. (20650456)
2010
7
Spontaneous cervical extradural hematoma in a cutaneo-meningospinal angiomatosis (Cobb syndrome): case report. (19546845)
2009
8
Skeletal angiomatosis - rare cause of bone destruction: a case report with review of literature. (19008580)
2008
9
Primary left ventricular angiomatosis: first description of a rare vascular tumor in the left heart. (16823253)
2006
10
Bilateral focal cerebral angiomatosis associated with nervous signs in a cat. (11355671)
2001
11
Skeletal cystic angiomatosis with severe hip joint deformation resembling massive osteolysis. (11550838)
2001
12
Imaging characteristics in a case of diffuse cystic angiomatosis. (10648046)
2000
13
Cutaneomeningospinal angiomatosis (Cobb syndrome) with tethered cord. (10325565)
1999
14
From polycystic bone angiomatosis to Gorham's disease. Two case-reports and literature review. (9574478)
1998
15
Fibrous long-spacing collagen in bacillary angiomatosis. (9615381)
1998
16
Bacillary angiomatosis: presentation of six patients, some with unusual features. (9039296)
1997
17
Widespread cutaneous bacillary angiomatosis and a large fungating mass in an HIV-positive man. (8698906)
1996
18
Cat-scratch disease and bacillary angiomatosis. (9025151)
1996
19
Coccal nail fold angiomatosis. (7756139)
1995
20
Bacillary angiomatosis with cutaneous and oral lesions in an HIV-infected patient from the U.K. (7756120)
1995
21
Bacillary angiomatosis in an immunocompetent child: the first reported case. (7899186)
1994
22
Bacillary angiomatosis. (8217903)
1993-1994
23
Correspondence Re: H. L. Ioachim, B. Dorsett, J. Melamed, V. Adsay and E. A. Santagada. Cytomegalovirus, angiomatosis and Kaposi's sarcoma: new observations of a debated relationship. Mod Pathol 5:169, 1992. (8381230)
1993
24
Test and teach. Number seventy-two. Diagnosis: Bacillary angiomatosis. (8265243)
1993
25
Cytomegalovirus, angiomatosis, and Kaposi's sarcoma: new observations of a debated relationship. (1315438)
1992
26
Peripapillary angiomatosis associated with cat-scratch neuroretinitis. (1543446)
1992
27
General case of the day. Cerebromeningeal angiomatosis (Sneddon syndrome). (1947326)
1991
28
Bacillary angiomatosis. (1868012)
1991
29
Hemodynamic changes after ruthenium irradiation of Hippel's angiomatosis. (2189085)
1990
30
Cutaneomeningo-spinal angiomatosis: the syndrome of Cobb. A case report. (2234322)
1990
31
Epithelioid angiomatosis in the acquired immunodeficiency syndrome: morphology and differential diagnosis. (2307419)
1990
32
Magnetic resonance imaging of meningio-angiomatosis. (3289706)
1988
33
Secondary bilateral synchrony in unilateral pial angiomatosis: successful surgical treatment. (3136229)
1988
34
Systemic cystic angiomatosis in a woman with hematuria and splenomegaly. (3607642)
1987
35
Angiomatosis: a vascular malformation of infancy and childhood. Report of 17 cases. (3444663)
1987
36
Atypical angiomatosis in polyarteritis nodosa. (2878681)
1986
37
Retinal angiomatosis: the ocular manifestations of von Hippel-Lindau disease. (3801976)
1986
38
Vascular tumors of the breast. III. Angiomatosis. (4051097)
1985
39
Intravascular angiomatosis in female urethral mass. Masson intravascular hemangioendothelioma. (6681683)
1983
40
Diffuse skeletal angiomatosis. (7347732)
1981
41
Cystic angiomatosis (hamartous haemolymphagiomatosis) of bone. A clinicopathological study of three cases. (627569)
1978
42
Haemorrhage due to renal angiomatosis. Case report. (948728)
1976
43
Nodal angiomatosis. (1120027)
1975
44
Familial capillaro-venous leptomeningeal angiomatosis. (4698574)
1973
45
Neurological classics XXXIX. Studies of cerebellar cysts. Structure, pathogenesis, and relation to angiomatosis retinae. (Lindau). (4938998)
1971
46
Von Hippel's angiomatosis retinae and pheochromocytoma. (5097817)
1971
47
Angiomatosis retinae. (5641355)
1968
48
Study of angiomatosis retinae. Report and management of two cases. (5602924)
1967
49
Difficulties in the diagnosis of the early stage of angiomatosis of the retina--von Hippel's disease. (5938408)
1966
50
Monk cap naevus, congenital kyphoscoliosis, angiomatosis and sarcomatosis of the central nervous system all combined in one patient, an atypical case of Recklinghausen's disease. (13285582)
1955

Genetic Variations for Angiomatosis

Expression for genes affiliated with Angiomatosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiomatosis

Search GEO for disease gene expression data for Angiomatosis.

Pathways for genes affiliated with Angiomatosis

Compounds for genes affiliated with Angiomatosis

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45Novoseek
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Compounds related to Angiomatosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin459.0TSC2, CD34, H19
2rapamycin458.9VHL, CCL26, TSC2
3tyrosine457.7TSC2, DLK1, CD34, H19, VHL

GO Terms for genes affiliated with Angiomatosis

Sources:
16Gene Ontology
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Biological processes related to Angiomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of gene expressionGO:0106299.3PLAG1, CD34

Products for genes affiliated with Angiomatosis

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Sources for Angiomatosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet