Aliases & Classifications for Angiomatosis

Aliases & Descriptions for Angiomatosis:

Name: Angiomatosis 51 52 69

Summaries for Angiomatosis

NINDS : 51 Von Hippel-Lindau disease (VHL) is a rare, genetic multi-system disorder in which non-cancerous tumors grow in certain parts of the body. Slow-growing hemgioblastomas -- benign tumors with many blood vessels -- may develop in the brain, spinal cord, the retinas of the eyes, and near the inner ear. Cysts (fluid-filled sacs) may develop around the hemangioblastomas. Other types of tumors develop in the adrenal glands, the kidneys, or the pancreas. Symptoms of VHL vary among individuals and depend on the size and location of the tumors. Symptoms may include headaches, problems with balance and walking, dizziness, weakness of the limbs, vision problems, deafness in one ear, and high blood pressure. Individuals with VHL are also at a higher risk than normal for certain types of cancer, especially kidney cancer.

MalaCards based summary : Angiomatosis is related to hemopneumothorax and hypomelanosis of ito. An important gene associated with Angiomatosis is VHL (Von Hippel-Lindau Tumor Suppressor), and among its related pathways/superpathways is PI3K-Akt signaling pathway. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and retina, and related phenotypes are Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection and cardiovascular system

Wikipedia : 71 Angiomatosis is a non-neoplastic condition presenting with little knots of capillaries in various... more...

Related Diseases for Angiomatosis

Diseases related to Angiomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
id Related Disease Score Top Affiliating Genes
1 hemopneumothorax 29.5 IFNA2 VHL
2 hypomelanosis of ito 28.4 FLT4 GALNT3 GLMN GYS1 IFNA2 PROX1
3 bacillary angiomatosis 12.2
4 diffuse dermal angiomatosis 12.2
5 skeletal-extraskeletal angiomatosis 11.9
6 breast angiomatosis 11.9
7 familial capillaro-venous leptomeningeal angiomatosis 11.9
8 angiomatosis, leptomeningeal capillary venous 11.8
9 sturge-weber syndrome, somatic, mosaic 11.8
10 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 11.8
11 cystic angiomatosis of bone, diffuse 11.7
12 cobb syndrome 11.2
13 bartonellosis 11.1
14 gorham's disease 11.0
15 von hippel-lindau syndrome 11.0
16 multiple enchondromatosis, maffucci type 10.7
17 multifocal lymphangioendotheliomatosis with thrombocytopenia 10.7
18 multiple mitochondrial dysfunctions syndrome 1 10.2 CCL26 TSC2
19 blue color blindness 10.2 CD4 IFNA2
20 fallopian tube adenofibroma 10.2 GNAQ IFNA2
21 stromal corneal pigmentation 10.2 CD4 IFNA2
22 retinitis 10.2
23 weber syndrome 10.1
24 facial nerve disease 10.1 GNAQ IFNA2
25 sarcoma 10.1
26 hydronephrosis 10.1 ATR CD4 CERKL
27 lysteria monocytoigeneses meningitis 10.1 FLT4 PROX1
28 oculodentodigital dysplasia 10.1 FLT4 PROX1
29 chromosome 18 pericentric inversion 10.1 FLT4 PROX1
30 cat-scratch disease 10.0
31 acrofacial dysostosis, patagonia type 10.0 FLT4 PROX1
32 benign familial neonatal epilepsy 10.0 FLT4 IFNA2 PROX1
33 weyers ulnar ray/oligodactyly syndrome 10.0 FLT4 GLMN GNAQ
34 acquired immunodeficiency syndrome 10.0
35 ovarian brenner tumor 9.9 FLT4 IFNA2 TSC2 VHL
36 cerebritis 9.9
37 keratosis follicularis spinulosa decalvans 9.9 FLT4 PROX1
38 saethre-chotzen syndrome 9.9 CD4 FLT4 IFNA2
39 leukemia 9.9
40 thrombocytopenia 9.9
41 meningitis 9.9
42 atherosclerosis 9.8
43 hepatitis 9.8
44 endotheliitis 9.8
45 bacteremia 9.8
46 chronic lymphocytic leukemia 9.8
47 mediastinitis 9.8
48 calciphylaxis 9.7
49 pancreatitis 9.7
50 pyogenic granuloma 9.7

Graphical network of the top 20 diseases related to Angiomatosis:



Diseases related to Angiomatosis

Symptoms & Phenotypes for Angiomatosis

GenomeRNAi Phenotypes related to Angiomatosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection GR00233-A-3 8.92 CCL26 FLT4 MED12 PROX1

MGI Mouse Phenotypes related to Angiomatosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 FLT4 PROX1 GALNT3 ATR GLMN GNAQ
2 cellular MP:0005384 10.1 DLK1 MED12 GLMN ATR CD4 CERKL
3 growth/size/body region MP:0005378 10.07 MED12 FLT4 PLAG1 PROX1 GALNT3 ATR
4 embryo MP:0005380 9.97 DLK1 MED12 PLAG1 FLT4 ATR GLMN
5 endocrine/exocrine gland MP:0005379 9.92 PLAG1 GALNT3 ATR GNAQ CD4 PROX1
6 homeostasis/metabolism MP:0005376 9.9 DLK1 FLT4 GALNT3 GLMN ATR GNAQ
7 liver/biliary system MP:0005370 9.5 FLT4 PROX1 ATR GYS1 DLK1 TSC2
8 normal MP:0002873 9.23 MED12 FLT4 ATR GNAQ CD4 PROX1

Drugs & Therapeutics for Angiomatosis

Drugs for Angiomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
2
Everolimus Approved Phase 2, Phase 3 159351-69-6 6442177
3
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 2, Phase 3
5 Anti-Infective Agents Phase 2, Phase 3
6 Immunosuppressive Agents Phase 2, Phase 3
7 Antifungal Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
10
Sunitinib Approved, Investigational Phase 2,Phase 1 341031-54-7, 557795-19-4 5329102
11
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
12
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
13
Pancrelipase Approved Phase 2 53608-75-6
14
Vatalanib Investigational Phase 2 212141-54-3 151194
15 Angiogenesis Inhibitors Phase 2,Phase 1,Early Phase 1
16 Angiogenesis Modulating Agents Phase 2,Phase 1,Early Phase 1
17 Fluorodeoxyglucose F18 Phase 2
18 Protein Kinase Inhibitors Phase 2
19 Radiopharmaceuticals Phase 2
20 Anticonvulsants Phase 1, Phase 2
21 pancreatin Phase 2
22 histidine Nutraceutical Phase 1, Phase 2
23
Bevacizumab Approved, Investigational Phase 1,Early Phase 1 216974-75-3
24
Timolol Approved Phase 1 26839-75-8 33624 5478
25
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
26
Maleic acid Experimental Phase 1 110-16-7 444266
27 Immunoglobulins Phase 1
28 Antibodies, Monoclonal Phase 1
29 Antibodies Phase 1
30 Adrenergic Agents Phase 1
31 Adrenergic Antagonists Phase 1
32 Neurotransmitter Agents Phase 1
33 Adrenergic beta-Antagonists Phase 1
34 Tetrahydrozoline Phase 1
35 Ophthalmic Solutions Phase 1
36 Anti-Arrhythmia Agents Phase 1
37 Antihypertensive Agents Phase 1
38 Lubricant Eye Drops Phase 1
39 Histone Deacetylase Inhibitors Phase 1
40 Mitogens
41 Dermatologic Agents
42 Endothelial Growth Factors
43 GTPase-Activating Proteins

Interventional clinical trials:

(show all 41)
id Name Status NCT ID Phase
1 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Recruiting NCT03047980 Phase 2, Phase 3
2 Study of Sunitinib in Patients With Von Hippel-Lindau (VHL) Disease Completed NCT01168440 Phase 2
3 Treatment of Von Hippel-Lindau (VHL)-Related Hemangioblastoma With PTK787/ZK 222584 Completed NCT00052013 Phase 2
4 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2
5 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2
6 Phase II Study of Vandetanib in Individuals With Kidney Cancer Completed NCT00566995 Phase 2
7 17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease Completed NCT00088374 Phase 2
8 A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab Recruiting NCT02859441 Phase 1, Phase 2
9 PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma Recruiting NCT03108066 Phase 2
10 Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine Tumors Recruiting NCT01967537 Phase 2
11 Pazopanib in Von Hippel-Lindau (VHL) Syndrome Active, not recruiting NCT01436227 Phase 2
12 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2
13 TKI 258 in Von Hippel-Lindau Syndrome (VHL) Terminated NCT01266070 Phase 2
14 Sunitinib Malate to Treat Advanced Eye Disease in Patients With Von Hippel-Lindau Syndrome Terminated NCT00673816 Phase 1, Phase 2
15 Evaluation of Sunitinib Malate in Patients With Von Hippel-Lindau Syndrome (VHL) Who Have VHL Lesions to Follow Terminated NCT00330564 Phase 2
16 Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS) Withdrawn NCT01997255 Phase 2
17 EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome Completed NCT00056199 Phase 1
18 Ranibizumab Injections to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome Completed NCT00089765 Phase 1
19 Use of the Atkins Diet for Children With Sturge Weber Syndrome Completed NCT00639730 Phase 1
20 Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol Recruiting NCT01533376 Phase 1
21 Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only) Enrolling by invitation NCT02108002 Phase 1
22 Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas Completed NCT00374335
23 Hemangioma Associated With High Rates of Morbidity Completed NCT00394888
24 Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors Completed NCT00001668
25 Biomarker Development in Sturge-Weber Syndrome Completed NCT01345305
26 Visualizing Vascular Endothelial Growth Factor (VEGF) Producing Lesions in Von Hippel-Lindau Disease Completed NCT00970970
27 Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) Completed NCT00610402
28 Genetic Study to Identify Gene Mutations in Participants Previously Enrolled in Clinical Trial NCI-99-C-0053 Who Have Von Hippel-Lindau Syndrome or Are at Risk for Von Hippel-Lindau Syndrome Completed NCT00075348
29 Registry for Vascular Anomalies Associated With Coagulopathy Recruiting NCT00576888
30 Screening for Endolymphatic Sac Tumours (ELSTs) in Von Hippel-Lindau (vHL) Patients Recruiting NCT02420067
31 Natural History and Management of Pancreatic Lesions in Von Hippel-Lindau Disease Recruiting NCT00062166
32 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
33 Lymphatic Anomalies Registry Recruiting NCT02399527
34 National Eye Institute Biorepository for Retinal Diseases Recruiting NCT01496625
35 Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome Recruiting NCT01425944
36 Von Hippel-Lindau Disease Genetic Epidemiology Study Active, not recruiting NCT00001803
37 Psychosocial Consequences of the Screening of Von Hippel Lindau Diseases for Patients Operated for a hémangioblastoma of Nervous Centrasl System Active, not recruiting NCT02120040
38 French National Cohort of Children With Port Wine Stain Active, not recruiting NCT01364857
39 Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease Active, not recruiting NCT00005902
40 Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease? Enrolling by invitation NCT02207686
41 Bevacizumab (Avastin) in Unresectable/Recurrent Hemangioblastoma From Von-Hippel-Lindau Disease Terminated NCT01015300 Early Phase 1

Search NIH Clinical Center for Angiomatosis

Genetic Tests for Angiomatosis

Anatomical Context for Angiomatosis

MalaCards organs/tissues related to Angiomatosis:

39
Brain, Kidney, Retina, Spinal Cord, Eye, Adrenal Gland, Pancreas

Publications for Angiomatosis

Articles related to Angiomatosis:

(show top 50) (show all 545)
id Title Authors Year
1
Obscure Overt Gastrointestinal Bleeding Due To Isolated Small Bowel Angiomatosis. ( 27144197 )
2016
2
Bacillary angiomatosis presenting with facial tumor and multiple abscesses: A case report. ( 27428207 )
2016
3
Diffuse Dermal Angiomatosis of the Breast With an Apparent Etiology of Underlying Calcified Thrombosed Artery With Adjacent Fat Necrosis. ( 27097335 )
2016
4
Bacillary angiomatosis presenting with polymorphic skin lesions. ( 27752473 )
2016
5
Bullous erythema ab igne with cutaneous reactive angiomatosis. ( 27226050 )
2016
6
Endothelial chimerism in chronic sclerotic-type chronic Graft-versus-Host disease and GVHD-associated angiomatosis. ( 26875995 )
2016
7
Angiomatosis dAcrmica difusa de la mama: aportaciA^n de un nuevo caso en paciente no fumadora. ( 27617469 )
2016
8
Graft-versus-host Disease-associated Angiomatosis Treated With Topical Timolol Solution. ( 27191176 )
2016
9
Successful treatment of bacillary angiomatosis with oral doxycycline in an HIV-infected child with skin lesions mimicking Kaposi sarcoma. ( 27051835 )
2016
10
Persistent cutaneous abdominal ulcerations secondary to diffuse dermal angiomatosis: an underestimated sign for severe atherosclerosis: A case report. ( 27442644 )
2016
11
Diffuse Dermal Angiomatosis: A Clue to the Diagnosis of Atherosclerotic Vascular Disease. ( 26120304 )
2015
12
Imaging features of systemic cystic angiomatosis. ( 26141486 )
2015
13
Cutaneous bacillary angiomatosis due to Bartonella quintana in a renal transplant recipient. ( 25652715 )
2015
14
Diffuse dermal angiomatosis of the abdomen. ( 26066057 )
2015
15
Diffuse dermal angiomatosis associated with severe atherosclerosis: two cases and review of the literature. ( 25639294 )
2015
16
Bacillary Angiomatosis in Immunocompetent Patient with Atypical Manifestations. ( 26538736 )
2015
17
Diffuse dermal angiomatosis: a clinical mimicker of vasculitis associated with calciphylaxis and monoclonal gammopathy. ( 25502367 )
2015
18
Mediastinal angiomatosis: a rare case report. ( 26793386 )
2015
19
Diffuse dermal angiomatosis of the breast: a series of 22 cases from a single institution. ( 26645009 )
2015
20
Leptomeningeal Angiomatosis in a Case of Neurofibromatosis Type 2: An Unusual Finding. ( 26510155 )
2015
21
Pneumothorax-associated fibroblastic lesion in combination with localized pleural angiomatosis: A possible cause of juvenile spontaneous hemopneumothorax. ( 25749626 )
2015
22
Bacillary angiomatosis presenting as a digital ulcer. ( 25994885 )
2015
23
Bacillary angiomatosis: A rare finding in the setting of antiretroviral drugs. ( 26636153 )
2015
24
Vaginal angiomatosis: differential diagnosis of a rare case. ( 26401116 )
2015
25
Wyburn-Mason Syndrome Associated With Cutaneous Reactive Angiomatosis and Central Retinal Vein Occlusion. ( 26247458 )
2015
26
Letter to the Editor Regarding Sturge-Weber Syndrome (Encephalotrigeminal Angiomatosis): Recent Advances and Future Challenges. ( 26147014 )
2015
27
Pulmonary manifestation of a condition resembling Kasabach-Merritt syndrome in a woman with abdominal angiomatosis associated with consumptive coagulopathy--surgical management: a case report. ( 25956942 )
2015
28
Angiomatosis: A Rare Vascular Proliferation of Head and Neck Region. ( 26157312 )
2015
29
Diffuse Breast Angiomatosis With Involvement ofA Overlying Skin: A Case Report. ( 26456034 )
2015
30
Bacillary Angiomatosis Masquerading as Kaposi Sarcoma in East Africa. ( 24718378 )
2014
31
Bacillary angiomatosis in a HIV-positive patient with poor adherence to antiretroviral therapy. ( 25580791 )
2014
32
Mediastinal angiomatosis. ( 25193206 )
2014
33
Diffuse angiomatosis of the breast--sonographic appearance. ( 24965677 )
2014
34
Cutaneovisceral angiomatosis with thrombocytopenia without cutaneous involvement. ( 25088066 )
2014
35
Tumoral bacillary angiomatosis in a child with human immunodeficiency virus. ( 25076357 )
2014
36
A case of bacillary angiomatosis in a patient with pancreatic adenocarcinoma. ( 24588271 )
2014
37
Sturge-Weber Syndrome (Encephalotrigeminal Angiomatosis): Recent Advances and Future Challenges. ( 26107979 )
2014
38
Bacillary angiomatosis. ( 25187668 )
2014
39
Propranolol for cerebral cavernous angiomatosis: a magic bullet. ( 23804539 )
2014
40
Graft-versus-host disease-associated angiomatosis: a clinicopathologically distinct entity. ( 24993601 )
2014
41
Cutaneous reactive angiomatosis with foreign body reaction after total knee replacement with a defective implant: a diagnostic challenge with a review of the literature. ( 24635713 )
2014
42
Diffuse dermal angiomatosis: a contributory factor to ulceration in a patient with renal transplant. ( 25265928 )
2014
43
Dental management in an encephalotrigeminal angiomatosis patient: a case report. ( 25284546 )
2014
44
Diffuse dermal angiomatosis of the breast: Clinicopathologic study of 5 patients. ( 25264238 )
2014
45
Cystic bone angiomatosis: a case report treated with aminobisphosphonates and review of the literature. ( 23836156 )
2013
46
Bacillary Angiomatosis in Patients With Cancer: A Pediatric Case Report and a Review of the Literature. ( 26619465 )
2013
47
Angiomatosis of the thoracic wall. ( 21773787 )
2013
48
Cutaneous reactive angiomatosis associated with erythema ab igne. ( 24266664 )
2013
49
Progressive late-onset of cutaneous angiomatosis as possible sign of cerebral cavernous malformations. ( 23473272 )
2013
50
Multi-system progressive angiomatosis in a dog resembling blue rubber bleb nevus syndrome in humans. ( 23496103 )
2013

Variations for Angiomatosis

Expression for Angiomatosis

Search GEO for disease gene expression data for Angiomatosis.

Pathways for Angiomatosis

Pathways related to Angiomatosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.46 FLT4 GYS1 IFNA2 TSC2

GO Terms for Angiomatosis

Biological processes related to Angiomatosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.8 CD4 IFNA2 MED12 PROX1 VHL
2 lymph vessel development GO:0001945 9.37 FLT4 PROX1
3 neural tube closure GO:0001843 9.33 GLMN MED12 TSC2
4 lymphangiogenesis GO:0001946 9.32 FLT4 PROX1
5 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.26 CD4 GLMN
6 heart development GO:0007507 9.26 GNAQ GYS1 MED12 TSC2
7 positive regulation of endothelial cell proliferation GO:0001938 8.8 CCL26 FLT4 PROX1

Sources for Angiomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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