MCID: ANG037
MIFTS: 38

Angiomatosis malady

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Summaries for Angiomatosis

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NINDS:43 Von Hippel-Lindau disease (VHL) is a rare, genetic multi-system disorder characterized by the abnormal growth of tumors in certain parts of the body. The tumors of the central nervous system (CNS) are benign and are comprised of a nest of blood vessels and are called hemangioblastomas. Hemangioblastomas may develop in the brain, the retina of the eyes, and other areas of the nervous system. Other types of tumors develop in the adrenal glands, the kidneys, or the pancreas. Symptoms of VHL vary among patients and depend on the size and location of the tumors. Symptoms may include headaches, problems with balance and walking, dizziness, weakness of the limbs, vision problems, and high blood pressure. Cysts (fluid-filled sacs) and/or tumors (benign or cancerous) may develop around the hemangioblastomas and cause the symptoms listed above. Individuals with VHL are also at a higher risk than normal for certain types of cancer, especially kidney cancer.

MalaCards based summary: Angiomatosis is related to von hippel-lindau disease and tuberous sclerosis complex. An important gene associated with Angiomatosis is VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase), and among its related pathways is ERK Signaling. The compounds cytosine and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and retina, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:65 Angiomatosis is a non-neoplastic condition presenting with little knots of capillaries in various... more...

Aliases & Classifications for Angiomatosis

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Sources:
43NINDS, 44Novoseek, 62UMLS
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Angiomatosis, Aliases & Descriptions:

Name: Angiomatosis 43 44 62


Related Diseases for Angiomatosis

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Diseases related to Angiomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1von hippel-lindau disease31.1VHL, TSC2
2tuberous sclerosis complex30.4TSC2
3tuberous sclerosis30.1VHL, CCL26, TSC2
4neurofibromatosis30.0VHL, TSC2
5pheochromocytoma29.6H19, VHL, DLK1
6lung cancer29.5TSC2, CCL26, H19, VHL
7adenoma29.3PLAG1, H19, VHL
8adenocarcinoma29.1TSC2, CCL26, PLAG1, H19, VHL
9diffuse dermal angiomatosis10.6
10retinitis10.6
11sturge-weber syndrome10.5
12sarcoma10.5
13weber syndrome10.5
14cat-scratch disease10.5
15kaposi's sarcoma10.4
16acquired immunodeficiency syndrome10.4
17perivascular epithelioid cell tumor10.4TSC2
18lymphangioleiomyomatosis10.4TSC2
19cerebritis10.3
20thrombocytopenia10.3
21meningitis10.3
22hepatitis10.2
23leukemia10.2
24cobb syndrome10.2
25familial capillaro-venous leptomeningeal angiomatosis10.2
26sturge-weber syndrome, somatic, mosaic10.2
27angiomatosis, leptomeningeal capillary venous10.2
28peutz-jeghers syndrome10.2VHL, TSC2
29angiomyolipoma10.2TSC2, CCL26
30polycystic kidney disease10.2VHL, TSC2
31atherosclerosis10.1
32chronic lymphocytic leukemia10.1
33breast angiomatosis10.1
34ollier disease10.1
35gorham's disease10.1
36cervicitis10.1
37mediastinitis10.1
38pancreatitis10.1
39angiomatosis, diffuse corticomeningeal, of divry and van bogaert10.1
40pyogenic granuloma10.1
41bacteremia10.1
42endotheliitis10.1
43kidney rhabdoid cancer10.1VHL, TSC2
44hemangioma10.0
45klippel-trenaunay syndrome10.0
46peliosis hepatis10.0
47calciphylaxis10.0
48angiosarcoma10.0
49neuropathy10.0
50blue rubber bleb nevus syndrome10.0

Graphical network of the top 20 diseases related to Angiomatosis:



Diseases related to angiomatosis

Symptoms for Angiomatosis

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Drugs & Therapeutics for Angiomatosis

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Drug clinical trials:

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Genetic Tests for Angiomatosis

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Anatomical Context for Angiomatosis

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MalaCards organs/tissues related to Angiomatosis:

32
Brain, Kidney, Retina, Eye, Pancreas, Adrenal gland, Bone, Breast, Skin, Bone marrow, Lymph node, Spleen, Lung, Endothelial, Heart, Colon, Uterus, Testes, Tongue, Cerebellum, Spinal cord, Liver, Occipital lobe, Neutrophil

Animal Models for Angiomatosis or affiliated genes

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MGI Mouse Phenotypes related to Angiomatosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8TSC2, H19, VHL
2MP:00053708.6DLK1, VHL, TSC2
3MP:00053898.1DLK1, VHL, TSC2, PLAG1
4MP:00053847.8TSC2, DLK1, VHL, H19
5MP:00053807.7DLK1, TSC2, PLAG1, H19, VHL
6MP:00053787.6VHL, DLK1, PLAG1, TSC2, H19

Publications for Angiomatosis

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Articles related to Angiomatosis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Propranolol for cerebral cavernous angiomatosis: a magic bullet. (23804539)
2014
2
A case of bacillary angiomatosis in a patient with pancreatic adenocarcinoma. (24588271)
2014
3
Extensive subarachnoid venous angiomatosis with hydrocephalus in phacomatosis pigmentovascularis. (24019387)
2013
4
Cutaneous reactive angiomatosis with combined histological pattern mimicking a cellulitis. (24107746)
2013
5
Refractory Bartonella quintana bacillary angiomatosis following chemotherapy for chronic lymphocytic leukaemia. (20947664)
2011
6
Diffuse dermal angiomatosis arising in cutis marmorata telangiectatica congenita. (21079080)
2010
7
Atherosclerosis-induced diffuse dermal angiomatosis with fatal outcome. (20566943)
2010
8
Bacillary angiomatosis after skin autografting in a patient without human immunodeficiency virus who was treated with interferon alfa. (20713840)
2010
9
A case of recurrent eruptive pseudo-angiomatosis that responded well to pimecrolimus 1% cream. (19060471)
2009
10
Invasive cutaneous angiomatosis and thrombocytopenia in a cat. (19210261)
2009
11
Hepatic peliosis (bacillary angiomatosis) in AIDS: CT findings. (16245016)
2005
12
Diffuse abdominal angiomatosis. (15120179)
2004
13
Encephalofacial angiomatosis sparing the occipital lobe and without facial nevus: on the spectrum of Sturge-Weber syndrome variants? (12661936)
2003
14
Cutaneous bacillary angiomatosis. (12503674)
2002
15
Bacillary angiomatosis in an immune-competent patient. (17664700)
2001
16
Bilateral focal cerebral angiomatosis associated with nervous signs in a cat. (11355671)
2001
17
Skeletal cystic angiomatosis with severe hip joint deformation resembling massive osteolysis. (11550838)
2001
18
Angiomatosis of the hand demonstrated by contrast-enhanced magnetic resonance angiogram. (10849984)
2000
19
Consecutive bacillary angiomatosis and Rhodococcus equi bacteremia during acute leukemia: zoonoses may cause fever in neutropenic patients. (11168145)
2000
20
Angiomatosis of skin with local intravascular immunoglobulin deposits, associated with monoclonal gammopathy. A potential cutaneous marker for B-chronic lymphocytic leukemia. A report of unusual case with immunohistochemical and immunofluorescence correlation and review of the literature. (10335899)
1999
21
HHV-8 (KSHV) is not associated with bacillary angiomatosis. (10748868)
1999
22
Bacillary angiomatosis in an immunocompetent child: the first reported case. (7899186)
1994
23
Cavernous angiomatosis of the central nervous system: usefulness of screening the family. (8256569)
1993
24
Bacillary angiomatosis and bacillary splenitis in immunocompetent adults. (8430982)
1993
25
Rochalimaea henselae causes bacillary angiomatosis and peliosis hepatis. (1546924)
1992
26
Intracerebral bacillary angiomatosis in a patient infected with human immunodeficiency virus. (1558347)
1992
27
Angiomatosis with luminal cryoprotein deposition. (1479103)
1992
28
Isolation of Rochalimaea species from cutaneous and osseous lesions of bacillary angiomatosis. (1435899)
1992
29
Bacillary epithelioid angiomatosis involving the liver, spleen, and skin in an AIDS patient with concurrent Kaposi's sarcoma. (1575216)
1992
30
The clinical spectrum of bacillary angiomatosis. (1610703)
1992
31
The causative agent of bacillary angiomatosis. (1459755)
1992
32
Localization of Mycobacterium avium-intracellulare within a skin lesion of bacillary angiomatosis in a patient with AIDS. (1285277)
1992
33
The causative agent of bacillary angiomatosis. (1922261)
1991
34
Diffuse pulmonary angiomatosis. (1771607)
1991
35
Skeletal angiomatosis limited to the hand: radiographic and scintigraphic correlation. (1919731)
1991
36
Epithelioid angiomatosis in patients with AIDS. Report of seven cases and review of the literature. (2195074)
1990
37
The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens. (2233945)
1990
38
Systemic cystic angiomatosis in a woman with hematuria and splenomegaly. (3607642)
1987
39
Vascular tumors of the breast. III. Angiomatosis. (4051097)
1985
40
Spinal angiomatosis presenting as a sensory neuropathy. (3981207)
1985
41
Intravascular angiomatosis. (277885)
1978
42
Angiomatosis of the metacarpal skeleton. (892634)
1977
43
Intravascular angiomatosis: development and distinction from angiosarcoma. (1237350)
1975
44
Diffuse cystic angiomatosis of bone. Report of two cases. (4712760)
1973
45
Incipient lesions in angiomatosis retinae. (4801574)
1973
46
Von Hippel-Lindau disease: the recognition and treatment of early angiomatosis retinae and the use of cryosurgery as an adjunct to therapy. (5535648)
1970
47
Encephalotrigeminal angiomatosis. (Sturge-Weber Syndrome). (5802220)
1969
48
Infantile form of meningeal angiomatosis with sudanophilic leucodystrophy associated with complex abiotrophies. Study of a second family. (5709854)
1968
49
Angiomatosis retinae. (5936813)
1966
50
ANGIOMATOSIS. (14226777)
1964

Variations for Angiomatosis

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Expression for genes affiliated with Angiomatosis

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Expression patterns in normal tissues for genes affiliated with Angiomatosis

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Pathways for genes affiliated with Angiomatosis

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Pathways related to Angiomatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0VHL, CCL26, TSC2

Compounds for genes affiliated with Angiomatosis

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Sources:
44Novoseek, 24HMDB
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Compounds related to Angiomatosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cytosine44 2410.5VHL, H19
25-aza-2deoxycytidine449.2VHL, H19
3rapamycin449.1TSC2, CCL26, VHL
4oxygen44 249.9TSC2, VHL, CCL26
5glucose448.6TSC2, VHL, DLK1
6tyrosine448.2DLK1, VHL, H19, TSC2

GO Terms for genes affiliated with Angiomatosis

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Products for genes affiliated with Angiomatosis

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  • Antibodies
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Sources for Angiomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet