MCID: ANG037
MIFTS: 26

Angiomatosis malady

Summaries for Angiomatosis

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Von Hippel-Lindau disease (VHL) is a rare, genetic multi-system disorder characterized by the abnormal growth of tumors in certain parts of the body. The tumors of the central nervous system (CNS) are benign and are comprised of a nest of blood vessels and are called hemangioblastomas. Hemangioblastomas may develop in the brain, the retina of the eyes, and other areas of the nervous system. Other types of tumors develop in the adrenal glands, the kidneys, or the pancreas. Symptoms of VHL vary among patients and depend on the size and location of the tumors. Symptoms may include headaches, problems with balance and walking, dizziness, weakness of the limbs, vision problems, and high blood pressure. Cysts (fluid-filled sacs) and/or tumors (benign or cancerous) may develop around the hemangioblastomas and cause the symptoms listed above. Individuals with VHL are also at a higher risk than normal for certain types of cancer, especially kidney cancer.

MalaCards: Angiomatosis is related to von hippel-lindau disease and leukemia. An important gene associated with Angiomatosis is VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase). The compounds paraffin and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and eye, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Wikipedia:63 Angiomatosis is a non-neoplastic condition presenting with little knots of capillaries in various... more...

Aliases & Classifications for Angiomatosis

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43NINDS, 44Novoseek, 60UMLS
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Aliases & Descriptions:

angiomatosis 43 44 60


Related Diseases for Angiomatosis

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17GeneCards, 18GeneDecks
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Diseases related to Angiomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1von hippel-lindau disease30.6TSC2, VHL
2leukemia30.3PLAG1, CD34, H19
3hemangioma29.9CD34, VHL
4tuberous sclerosis29.9TSC2, CCL26, VHL
5lung cancer29.9TSC2, H19, CCL26, VHL
6esophagitis29.7CCL26
7hemangioblastoma29.7VHL
8meningioma29.7CD34
9neurofibromatosis29.7TSC2, VHL
10adenoma29.7PLAG1, H19, VHL
11leiomyoma29.7CD34, TSC2
12pheochromocytoma29.7DLK1, H19, VHL
13acute leukemia29.7TSC2, CD34
14adenocarcinoma29.7VHL, CCL26, H19, CD34, PLAG1, TSC2
15retinitis10.5
16sarcoma10.4
17cat-scratch disease10.4
18breast angiomatosis10.4
19kaposi's sarcoma10.4
20acquired immunodeficiency syndrome10.3
21cerebritis10.3
22retinal disease10.2
23meningitis10.2
24diffuse dermal angiomatosis10.2
25sturge-weber syndrome10.2
26sturge-weber syndrome, somatic, mosaic10.2
27hepatitis10.2
28thrombocytopenia10.2
29chronic lymphocytic leukemia10.1
30angiomatosis, leptomeningeal capillary venous10.1
31familial capillaro-venous leptomeningeal angiomatosis10.1
32klippel-trenaunay syndrome10.1
33gorham's disease10.1
34atherosclerosis10.1
35cervicitis10.1
36epithelioid sarcoma10.1
37angiomatosis, diffuse corticomeningeal, of divry and van bogaert10.1
38cobb syndrome10.1
39glomus tumor10.0VHL
40hemangioendothelioma10.0CD34
41fibrosarcoma10.0CD34
42myeloid leukemia10.0CD34
43perivascular epithelioid cell tumor10.0TSC2
44neurofibroma10.0CD34
45cystadenoma10.0VHL
46vascular cancer10.0VHL, CD34
47endometrial carcinoma10.0CD34
48lymphangioleiomyomatosis10.0TSC2
49lipoma10.0PLAG1, CD34
50adrenal adenoma10.0H19, VHL

Graphical network of the top 20 diseases related to Angiomatosis:



Diseases related to angiomatosis

Clinical Features for Angiomatosis

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Drugs & Therapeutics for Angiomatosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Angiomatosis

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Anatomical Context for Angiomatosis

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32MalaCards
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MalaCards organs/tissues related to Angiomatosis:

32
Brain, Kidney, Eye, Retina, Pancreas, Adrenal gland

Animal Models for Angiomatosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiomatosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.3H19, PLAG1
2MP:00020068.7H19, VHL, TSC2, CD34
3MP:00053708.3TSC2, DLK1, H19, VHL
4MP:00053807.8TSC2, DLK1, H19, VHL, PLAG1
5MP:00053787.7VHL, H19, DLK1, PLAG1, TSC2
6MP:00053847.5TSC2, DLK1, CD34, H19, VHL

Publications for Angiomatosis

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Genetic Variations for Angiomatosis

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Expression for genes affiliated with Angiomatosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiomatosis

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Pathways for genes affiliated with Angiomatosis

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Compounds for genes affiliated with Angiomatosis

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44Novoseek
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Compounds related to Angiomatosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin449.0H19, CD34, TSC2
2rapamycin448.9CCL26, TSC2, VHL
3tyrosine447.7TSC2, DLK1, CD34, H19, VHL

GO Terms for genes affiliated with Angiomatosis

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16Gene Ontology
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Biological processes related to Angiomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of gene expressionGO:0106299.3PLAG1, CD34

Products for genes affiliated with Angiomatosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angiomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet