MCID: ANG037
MIFTS: 38

Angiomatosis malady

Summaries for Angiomatosis

About this section
Sources:
45NINDS, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
NINDS:45 Von Hippel-Lindau disease (VHL) is a rare, genetic multi-system disorder characterized by the abnormal growth of tumors in certain parts of the body. The tumors of the central nervous system (CNS) are benign and are comprised of a nest of blood vessels and are called hemangioblastomas. Hemangioblastomas may develop in the brain, the retina of the eyes, and other areas of the nervous system. Other types of tumors develop in the adrenal glands, the kidneys, or the pancreas. Symptoms of VHL vary among patients and depend on the size and location of the tumors. Symptoms may include headaches, problems with balance and walking, dizziness, weakness of the limbs, vision problems, and high blood pressure. Cysts (fluid-filled sacs) and/or tumors (benign or cancerous) may develop around the hemangioblastomas and cause the symptoms listed above. Individuals with VHL are also at a higher risk than normal for certain types of cancer, especially kidney cancer.

MalaCards: Angiomatosis is related to von hippel-lindau disease and tuberous sclerosis. An important gene associated with Angiomatosis is VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase), and among its related pathways is ERK Signaling. The compounds cytosine and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and retina, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:66 Angiomatosis is a non-neoplastic condition presenting with little knots of capillaries in various... more...

Aliases & Classifications for Angiomatosis

About this section
Sources:
45NINDS, 46Novoseek, 63UMLS
See all sources

Aliases & Descriptions:

angiomatosis 45 46 63


Related Diseases for Angiomatosis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Angiomatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1von hippel-lindau disease30.8VHL, TSC2
2tuberous sclerosis30.0VHL, CCL26, TSC2
3tuberous sclerosis complex29.9TSC2
4lung cancer29.9TSC2, CCL26, H19, VHL
5neurofibromatosis29.8VHL, TSC2
6pheochromocytoma29.7H19, VHL, DLK1
7adenoma29.7PLAG1, H19, VHL
8adenocarcinoma29.6TSC2, CCL26, PLAG1, H19, VHL
9diffuse dermal angiomatosis10.6
10retinitis10.5
11sturge-weber syndrome10.5
12sarcoma10.5
13weber syndrome10.5
14cat-scratch disease10.4
15kaposi's sarcoma10.4
16acquired immunodeficiency syndrome10.4
17cerebritis10.3
18leukemia10.3
19meningitis10.3
20hepatitis10.2
21thrombocytopenia10.2
22cobb syndrome10.2
23familial capillaro-venous leptomeningeal angiomatosis10.2
24sturge-weber syndrome, somatic, mosaic10.2
25chronic lymphocytic leukemia10.2
26angiomatosis, leptomeningeal capillary venous10.2
27bacteremia10.2
28breast angiomatosis10.1
29gorham's disease10.1
30atherosclerosis10.1
31cervicitis10.1
32angiomatosis, diffuse corticomeningeal, of divry and van bogaert10.1
33pyogenic granuloma10.1
34endotheliitis10.1
35perivascular epithelioid cell tumor10.1TSC2
36lymphangioleiomyomatosis10.1TSC2
37peutz-jeghers syndrome10.0VHL, TSC2
38angiomyolipoma10.0TSC2, CCL26
39polycystic kidney disease10.0VHL, TSC2
40kidney rhabdoid cancer10.0VHL, TSC2
41klippel-trenaunay syndrome10.0
42peliosis hepatis10.0
43ollier disease10.0
44calciphylaxis10.0
45angiosarcoma10.0
46hemangioma10.0
47mediastinitis10.0
48neuropathy10.0
49pancreatitis10.0
50blue rubber bleb nevus syndrome10.0

Graphical network of the top 20 diseases related to Angiomatosis:



Diseases related to angiomatosis

Symptoms for Angiomatosis

About this section

Drugs & Therapeutics for Angiomatosis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Angiomatosis

Drug clinical trials:

Search ClinicalTrials for Angiomatosis

Search NIH Clinical Center for Angiomatosis

Search CenterWatch for Angiomatosis

Genetic Tests for Angiomatosis

About this section

Anatomical Context for Angiomatosis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Angiomatosis:

34
Brain, Kidney, Retina, Eye, Adrenal gland, Pancreas, Bone, Breast, Skin, Bone marrow, Spleen, Lymph node, Lung, Endothelial, Tongue, Uterus, Colon, Heart, Testes, Spinal cord, Liver, Cerebellum, Occipital lobe

Animal Models for Angiomatosis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Angiomatosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8VHL, H19, TSC2
2MP:00053708.6DLK1, VHL, TSC2
3MP:00053898.1TSC2, PLAG1, VHL, DLK1
4MP:00053847.8TSC2, H19, VHL, DLK1
5MP:00053807.7DLK1, VHL, H19, PLAG1, TSC2
6MP:00053787.6TSC2, PLAG1, H19, VHL, DLK1

Publications for Angiomatosis

About this section
Sources:
53PubMed
See all sources

Articles related to Angiomatosis:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Propranolol for cerebral cavernous angiomatosis: a magic bullet. (23804539)
2014
2
Extensive subarachnoid venous angiomatosis with hydrocephalus in phacomatosis pigmentovascularis. (24019387)
2013
3
Cutaneous reactive angiomatosis with combined histological pattern mimicking a cellulitis. (24107746)
2013
4
Refractory Bartonella quintana bacillary angiomatosis following chemotherapy for chronic lymphocytic leukaemia. (20947664)
2011
5
Diffuse dermal angiomatosis arising in cutis marmorata telangiectatica congenita. (21079080)
2010
6
Atherosclerosis-induced diffuse dermal angiomatosis with fatal outcome. (20566943)
2010
7
Bacillary angiomatosis after skin autografting in a patient without human immunodeficiency virus who was treated with interferon alfa. (20713840)
2010
8
A case of recurrent eruptive pseudo-angiomatosis that responded well to pimecrolimus 1% cream. (19060471)
2009
9
Invasive cutaneous angiomatosis and thrombocytopenia in a cat. (19210261)
2009
10
Bacillary angiomatosis in a patient with chronic lymphocytic leukemia. (18165862)
2008
11
Hepatic peliosis (bacillary angiomatosis) in AIDS: CT findings. (16245016)
2005
12
Diffuse abdominal angiomatosis. (15120179)
2004
13
Encephalofacial angiomatosis sparing the occipital lobe and without facial nevus: on the spectrum of Sturge-Weber syndrome variants? (12661936)
2003
14
Cutaneous bacillary angiomatosis. (12503674)
2002
15
Bacillary angiomatosis in an immune-competent patient. (17664700)
2001
16
Bilateral focal cerebral angiomatosis associated with nervous signs in a cat. (11355671)
2001
17
Skeletal cystic angiomatosis with severe hip joint deformation resembling massive osteolysis. (11550838)
2001
18
Angiomatosis of the hand demonstrated by contrast-enhanced magnetic resonance angiogram. (10849984)
2000
19
Consecutive bacillary angiomatosis and Rhodococcus equi bacteremia during acute leukemia: zoonoses may cause fever in neutropenic patients. (11168145)
2000
20
Angiomatosis of skin with local intravascular immunoglobulin deposits, associated with monoclonal gammopathy. A potential cutaneous marker for B-chronic lymphocytic leukemia. A report of unusual case with immunohistochemical and immunofluorescence correlation and review of the literature. (10335899)
1999
21
HHV-8 (KSHV) is not associated with bacillary angiomatosis. (10748868)
1999
22
Bacillary angiomatosis in an immunocompetent child: the first reported case. (7899186)
1994
23
Bacillary angiomatosis and bacillary splenitis in immunocompetent adults. (8430982)
1993
24
Rochalimaea henselae causes bacillary angiomatosis and peliosis hepatis. (1546924)
1992
25
Intracerebral bacillary angiomatosis in a patient infected with human immunodeficiency virus. (1558347)
1992
26
Angiomatosis with luminal cryoprotein deposition. (1479103)
1992
27
Isolation of Rochalimaea species from cutaneous and osseous lesions of bacillary angiomatosis. (1435899)
1992
28
Bacillary epithelioid angiomatosis involving the liver, spleen, and skin in an AIDS patient with concurrent Kaposi's sarcoma. (1575216)
1992
29
The clinical spectrum of bacillary angiomatosis. (1610703)
1992
30
The causative agent of bacillary angiomatosis. (1459755)
1992
31
Localization of Mycobacterium avium-intracellulare within a skin lesion of bacillary angiomatosis in a patient with AIDS. (1285277)
1992
32
The causative agent of bacillary angiomatosis. (1922261)
1991
33
Diffuse pulmonary angiomatosis. (1771607)
1991
34
Skeletal angiomatosis limited to the hand: radiographic and scintigraphic correlation. (1919731)
1991
35
Epithelioid angiomatosis in patients with AIDS. Report of seven cases and review of the literature. (2195074)
1990
36
The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens. (2233945)
1990
37
Systemic cystic angiomatosis in a woman with hematuria and splenomegaly. (3607642)
1987
38
Vascular tumors of the breast. III. Angiomatosis. (4051097)
1985
39
Spinal angiomatosis presenting as a sensory neuropathy. (3981207)
1985
40
von Hippel-Lindau disease: angiomatosis of the retina and central nervous system. (7322482)
1981
41
Intravascular angiomatosis. (277885)
1978
42
Angiomatosis of the metacarpal skeleton. (892634)
1977
43
Intravascular angiomatosis: development and distinction from angiosarcoma. (1237350)
1975
44
Diffuse cystic angiomatosis of bone. Report of two cases. (4712760)
1973
45
Incipient lesions in angiomatosis retinae. (4801574)
1973
46
Von Hippel-Lindau disease: the recognition and treatment of early angiomatosis retinae and the use of cryosurgery as an adjunct to therapy. (5535648)
1970
47
Encephalotrigeminal angiomatosis. (Sturge-Weber Syndrome). (5802220)
1969
48
Infantile form of meningeal angiomatosis with sudanophilic leucodystrophy associated with complex abiotrophies. Study of a second family. (5709854)
1968
49
Angiomatosis retinae. (5936813)
1966
50
ANGIOMATOSIS. (14226777)
1964

Variations for Angiomatosis

About this section

Expression for genes affiliated with Angiomatosis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Angiomatosis

Search GEO for disease gene expression data for Angiomatosis.

Pathways for genes affiliated with Angiomatosis

About this section
Sources:
51PathCards, 54QIAGEN
See all sources

Pathways related to Angiomatosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0VHL, CCL26, TSC2

Compounds for genes affiliated with Angiomatosis

About this section
Sources:
46Novoseek, 25HMDB
See all sources

Compounds related to Angiomatosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cytosine46 2510.5VHL, H19
25-aza-2deoxycytidine469.2VHL, H19
3rapamycin469.1TSC2, CCL26, VHL
4oxygen46 259.9TSC2, VHL, CCL26
5glucose468.6TSC2, VHL, DLK1
6tyrosine468.2DLK1, VHL, H19, TSC2

GO Terms for genes affiliated with Angiomatosis

About this section

Products for genes affiliated with Angiomatosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angiomatosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet