Aliases & Classifications for Angiomatosis

MalaCards integrated aliases for Angiomatosis:

Name: Angiomatosis 51 52 69

Summaries for Angiomatosis

NINDS : 51 Von Hippel-Lindau disease (VHL) is a rare, genetic multi-system disorder in which non-cancerous tumors grow in certain parts of the body. Slow-growing hemgioblastomas -- benign tumors with many blood vessels -- may develop in the brain, spinal cord, the retinas of the eyes, and near the inner ear. Cysts (fluid-filled sacs) may develop around the hemangioblastomas. Other types of tumors develop in the adrenal glands, the kidneys, or the pancreas. Symptoms of VHL vary among individuals and depend on the size and location of the tumors. Symptoms may include headaches, problems with balance and walking, dizziness, weakness of the limbs, vision problems, deafness in one ear, and high blood pressure. Individuals with VHL are also at a higher risk than normal for certain types of cancer, especially kidney cancer.

MalaCards based summary : Angiomatosis is related to bacillary angiomatosis and diffuse dermal angiomatosis. An important gene associated with Angiomatosis is VHL (Von Hippel-Lindau Tumor Suppressor), and among its related pathways/superpathways is Translation Translation regulation by Alpha-1 adrenergic receptors. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and retina, and related phenotypes are Increased shRNA abundance (Z-score > 2) and embryo

Wikipedia : 72 Angiomatosis is a non-neoplastic condition presenting with little knots of capillaries in various... more...

Related Diseases for Angiomatosis

Diseases related to Angiomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
id Related Disease Score Top Affiliating Genes
1 bacillary angiomatosis 12.2
2 diffuse dermal angiomatosis 12.2
3 skeletal-extraskeletal angiomatosis 11.9
4 breast angiomatosis 11.8
5 familial capillaro-venous leptomeningeal angiomatosis 11.8
6 angiomatosis, leptomeningeal capillary venous 11.8
7 sturge-weber syndrome, somatic, mosaic 11.8
8 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 11.8
9 cystic angiomatosis of bone, diffuse 11.7
10 cobb syndrome 11.2
11 bartonellosis 11.1
12 gorham's disease 11.0
13 von hippel-lindau syndrome 11.0
14 encephalocraniocutaneous lipomatosis 10.8
15 autism with port-wine stain 10.8
16 multiple enchondromatosis, maffucci type 10.7
17 multifocal lymphangioendotheliomatosis with thrombocytopenia 10.7
18 retinitis 10.2
19 weber syndrome 10.1
20 sarcoma 10.1
21 cat-scratch disease 10.0
22 acquired immunodeficiency syndrome 10.0
23 cerebritis 9.9
24 thrombocytopenia 9.9
25 lymphangioleiomyomatosis 9.9 CCL26 TSC2
26 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9 CCL26 TSC2
27 atherosclerosis 9.9
28 leukemia 9.9
29 meningitis 9.9
30 gangliosidosis gm2 9.8 CCL26 TSC2
31 hepatitis 9.8
32 mediastinitis 9.8
33 erythrocytosis, familial, 2 9.8 TSC2 VHL
34 benign struma ovarii 9.8 CCL26 TSC2
35 neurofibromatosis, familial spinal 9.8 TSC2 VHL
36 bacteremia 9.8
37 chronic lymphocytic leukemia 9.8
38 endotheliitis 9.8
39 kaposi sarcoma 9.7
40 cervicitis 9.7
41 calciphylaxis 9.7
42 pancreatitis 9.7
43 pyogenic granuloma 9.7
44 vascular malformation 9.7
45 lung cancer 9.6
46 klippel-trenaunay-weber syndrome 9.6
47 burns 9.6
48 hemangioma 9.6
49 angiosarcoma 9.6
50 cryptococcal meningitis 9.6

Graphical network of the top 20 diseases related to Angiomatosis:



Diseases related to Angiomatosis

Symptoms & Phenotypes for Angiomatosis

GenomeRNAi Phenotypes related to Angiomatosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.53 TSC2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.53 PLAG1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.53 TSC2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.53 TSC2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 PLAG1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.53 VHL
7 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.53 TSC2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.53 VHL
9 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.53 VHL PLAG1 TSC2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.53 PLAG1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.53 PLAG1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.53 VHL
13 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.53 TSC2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.53 PLAG1

MGI Mouse Phenotypes related to Angiomatosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.92 DLK1 PLAG1 TSC2 VHL

Drugs & Therapeutics for Angiomatosis

Drugs for Angiomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 2, Phase 3 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 5284616 6436030 46835353
4 Anti-Bacterial Agents Phase 2, Phase 3
5 Antibiotics, Antitubercular Phase 2, Phase 3
6 Antifungal Agents Phase 2, Phase 3
7 Anti-Infective Agents Phase 2, Phase 3
8 Immunosuppressive Agents Phase 2, Phase 3
9 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
10
Sunitinib Approved, Investigational Phase 2,Phase 1 341031-54-7, 557795-19-4 5329102
11
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
12
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
13
Pancrelipase Approved Phase 2 53608-75-6
14
Vatalanib Investigational Phase 2 212141-54-3 151194
15 Angiogenesis Inhibitors Phase 2,Phase 1,Early Phase 1
16 Angiogenesis Modulating Agents Phase 2,Phase 1,Early Phase 1
17 Protein Kinase Inhibitors Phase 2
18 Fluorodeoxyglucose F18 Phase 2
19 Radiopharmaceuticals Phase 2
20 Anticonvulsants Phase 1, Phase 2
21 pancreatin Phase 2
22 histidine Nutraceutical Phase 1, Phase 2
23
Bevacizumab Approved, Investigational Phase 1,Early Phase 1 216974-75-3
24
Timolol Approved Phase 1 26839-75-8 33624 5478
25
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
26
Maleic acid Experimental Phase 1 110-16-7 444266
27 Antibodies Phase 1
28 Antibodies, Monoclonal Phase 1
29 Immunoglobulins Phase 1
30 Adrenergic Agents Phase 1
31 Adrenergic Antagonists Phase 1
32 Adrenergic beta-Antagonists Phase 1
33 Anti-Arrhythmia Agents Phase 1
34 Antihypertensive Agents Phase 1
35 Lubricant Eye Drops Phase 1
36 Neurotransmitter Agents Phase 1
37 Ophthalmic Solutions Phase 1
38 Tetrahydrozoline Phase 1
39 Histone Deacetylase Inhibitors Phase 1
40 Dermatologic Agents
41 Endothelial Growth Factors
42 Mitogens
43 GTPase-Activating Proteins

Interventional clinical trials:

(show all 41)

id Name Status NCT ID Phase Drugs
1 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
2 Study of Sunitinib in Patients With Von Hippel-Lindau (VHL) Disease Completed NCT01168440 Phase 2 Sunitinib
3 Treatment of Von Hippel-Lindau (VHL)-Related Hemangioblastoma With PTK787/ZK 222584 Completed NCT00052013 Phase 2 PTK787/ZK 222584
4 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
5 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
6 Phase II Study of Vandetanib in Individuals With Kidney Cancer Completed NCT00566995 Phase 2 ZACTIMA (Vandetanib) (ZD6474)
7 17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease Completed NCT00088374 Phase 2 17 allylamino-17-demethoxygeldanamycin;18 FDG (Fludeoxyglucose 18F);[15-O] H2O;EPL diluent
8 A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab Recruiting NCT02859441 Phase 1, Phase 2 Ranibizumab;E10030
9 Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine Tumors Recruiting NCT01967537 Phase 2 68Gallium DOTATATE
10 Pazopanib in Von Hippel-Lindau (VHL) Syndrome Active, not recruiting NCT01436227 Phase 2 Pazopanib
11 PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma Active, not recruiting NCT03108066 Phase 2 PT2385 Tablets
12 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2 Cannabidiol
13 TKI 258 in Von Hippel-Lindau Syndrome (VHL) Terminated NCT01266070 Phase 2 Dovitinib
14 Sunitinib Malate to Treat Advanced Eye Disease in Patients With Von Hippel-Lindau Syndrome Terminated NCT00673816 Phase 1, Phase 2 Sunitinib Malate
15 Evaluation of Sunitinib Malate in Patients With Von Hippel-Lindau Syndrome (VHL) Who Have VHL Lesions to Follow Terminated NCT00330564 Phase 2 SU011248
16 Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS) Withdrawn NCT01997255 Phase 2 Everolimus
17 EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome Completed NCT00056199 Phase 1 EYE001
18 Ranibizumab Injections to Treat Retinal Tumors in Patients With Von Hippel-Lindau Syndrome Completed NCT00089765 Phase 1 Ranibizumab
19 Use of the Atkins Diet for Children With Sturge Weber Syndrome Completed NCT00639730 Phase 1
20 Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol Recruiting NCT01533376 Phase 1 Timolol;Preservative free artificial tear gel.
21 Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only) Enrolling by invitation NCT02108002 Phase 1 Vorinostat
22 Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas Completed NCT00374335
23 Hemangioma Associated With High Rates of Morbidity Completed NCT00394888
24 Biomarker Development in Sturge-Weber Syndrome Completed NCT01345305
25 Visualizing Vascular Endothelial Growth Factor (VEGF) Producing Lesions in Von Hippel-Lindau Disease Completed NCT00970970
26 Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) Completed NCT00610402
27 Genetic Study to Identify Gene Mutations in Participants Previously Enrolled in Clinical Trial NCI-99-C-0053 Who Have Von Hippel-Lindau Syndrome or Are at Risk for Von Hippel-Lindau Syndrome Completed NCT00075348
28 Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors Completed NCT00001668
29 Registry for Vascular Anomalies Associated With Coagulopathy Recruiting NCT00576888
30 Screening for Endolymphatic Sac Tumours (ELSTs) in Von Hippel-Lindau (vHL) Patients Recruiting NCT02420067
31 Natural History and Management of Pancreatic Lesions in Von Hippel-Lindau Disease Recruiting NCT00062166
32 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
33 Lymphatic Anomalies Registry Recruiting NCT02399527
34 National Eye Institute Biorepository for Retinal Diseases Recruiting NCT01496625
35 Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome Recruiting NCT01425944
36 Psychosocial Consequences of the Screening of Von Hippel Lindau Diseases for Patients Operated for a hémangioblastoma of Nervous Centrasl System Active, not recruiting NCT02120040
37 Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease Active, not recruiting NCT00005902
38 Von Hippel-Lindau Disease Genetic Epidemiology Study Active, not recruiting NCT00001803
39 French National Cohort of Children With Port Wine Stain Active, not recruiting NCT01364857
40 Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease? Enrolling by invitation NCT02207686
41 Bevacizumab (Avastin) in Unresectable/Recurrent Hemangioblastoma From Von-Hippel-Lindau Disease Terminated NCT01015300 Early Phase 1 Avastin

Search NIH Clinical Center for Angiomatosis

Genetic Tests for Angiomatosis

Anatomical Context for Angiomatosis

MalaCards organs/tissues related to Angiomatosis:

39
Kidney, Brain, Retina, Eye, Spinal Cord, Bone, Pancreas

Publications for Angiomatosis

Articles related to Angiomatosis:

(show top 50) (show all 559)
id Title Authors Year
1
Focal angiomatosis of the breast with MRI and histologic features. ( 28491155 )
2017
2
Delayed Appearance of Cutaneous Lesions of Cutaneovisceral Angiomatosis (CAT) Leading to Misdiagnosis of Immune Thrombocytopenia. ( 28234740 )
2017
3
Angiomatosis of soft tissue as an important differential diagnosis for intramuscular venous malformations. ( 27688038 )
2017
4
Diffuse dermal angiomatosis mimicking inflammatory breast carcinoma. ( 28744985 )
2017
5
Intracranial Complications From Temporal Bone Cystic Angiomatosis. ( 27918367 )
2017
6
An unusual case of bacillary angiomatosis in the oral cavity of an AIDS patient who had no concomitant tegumentary lesions - case report and review. ( 28902296 )
2017
7
A case of suspected diffuse dermal angiomatosis associated with severe atherosclerosis. ( 28466447 )
2017
8
Diffuse angiomatosis with severe facial disfigurement. ( 28052359 )
2017
9
Cervicothoracic cutaneomeningospinal angiomatosis in adults (Cobb's syndrome): A case report of acute quadriparesis. ( 28791190 )
2017
10
Angiomatosis, Bacillary ( 28846267 )
2017
11
Cystic angiomatosis, a heterogeneous condition: Four new cases and a literature review. ( 27787381 )
2016
12
Angiomatosis dAcrmica difusa de la mama: aportaciA^n de un nuevo caso en paciente no fumadora. ( 27617469 )
2016
13
Endothelial chimerism in chronic sclerotic-type chronic Graft-versus-Host disease and GVHD-associated angiomatosis. ( 26875995 )
2016
14
Dumbbell-Mimicked Mediastinal Angiomatosis. ( 27847080 )
2016
15
Bacillary angiomatosis presenting with polymorphic skin lesions. ( 27752473 )
2016
16
Breast nodularity and ulceration: diffuse dermal angiomatosis a corticosteroid responsive disease. ( 28329566 )
2016
17
Bacillary angiomatosis presenting with facial tumor and multiple abscesses: A case report. ( 27428207 )
2016
18
Graft-versus-host Disease-associated Angiomatosis Treated With Topical Timolol Solution. ( 27191176 )
2016
19
Bullous erythema ab igne with cutaneous reactive angiomatosis. ( 27226050 )
2016
20
Successful treatment of bacillary angiomatosis with oral doxycycline in an HIV-infected child with skin lesions mimicking Kaposi sarcoma. ( 27051835 )
2016
21
Obscure Overt Gastrointestinal Bleeding Due To Isolated Small Bowel Angiomatosis. ( 27144197 )
2016
22
Persistent cutaneous abdominal ulcerations secondary to diffuse dermal angiomatosis: an underestimated sign for severe atherosclerosis: A case report. ( 27442644 )
2016
23
Diffuse Dermal Angiomatosis of the Breast With an Apparent Etiology of Underlying Calcified Thrombosed Artery With Adjacent Fat Necrosis. ( 27097335 )
2016
24
Bacillary angiomatosis with bone invasion. ( 28099606 )
2016
25
Vaginal angiomatosis: differential diagnosis of a rare case. ( 26401116 )
2015
26
Bacillary angiomatosis: A rare finding in the setting of antiretroviral drugs. ( 26636153 )
2015
27
Leptomeningeal Angiomatosis in a Case of Neurofibromatosis Type 2: An Unusual Finding. ( 26510155 )
2015
28
Bacillary Angiomatosis in Immunocompetent Patient with Atypical Manifestations. ( 26538736 )
2015
29
Diffuse dermal angiomatosis: a clinical mimicker of vasculitis associated with calciphylaxis and monoclonal gammopathy. ( 25502367 )
2015
30
Pulmonary manifestation of a condition resembling Kasabach-Merritt syndrome in a woman with abdominal angiomatosis associated with consumptive coagulopathy--surgical management: a case report. ( 25956942 )
2015
31
Cutaneous bacillary angiomatosis due to Bartonella quintana in a renal transplant recipient. ( 25652715 )
2015
32
Wyburn-Mason Syndrome Associated With Cutaneous Reactive Angiomatosis and Central Retinal Vein Occlusion. ( 26247458 )
2015
33
Bacillary angiomatosis presenting as a digital ulcer. ( 25994885 )
2015
34
Letter to the Editor Regarding Sturge-Weber Syndrome (Encephalotrigeminal Angiomatosis): Recent Advances and Future Challenges. ( 26147014 )
2015
35
Diffuse Dermal Angiomatosis: A Clue to the Diagnosis of Atherosclerotic Vascular Disease. ( 26120304 )
2015
36
Diffuse Breast Angiomatosis With Involvement ofA Overlying Skin: A Case Report. ( 26456034 )
2015
37
Imaging features of systemic cystic angiomatosis. ( 26141486 )
2015
38
Diffuse dermal angiomatosis of the abdomen. ( 26066057 )
2015
39
Mediastinal angiomatosis: a rare case report. ( 26793386 )
2015
40
Pneumothorax-associated fibroblastic lesion in combination with localized pleural angiomatosis: A possible cause of juvenile spontaneous hemopneumothorax. ( 25749626 )
2015
41
Diffuse dermal angiomatosis of the breast: a series of 22 cases from a single institution. ( 26645009 )
2015
42
Angiomatosis: A Rare Vascular Proliferation of Head and Neck Region. ( 26157312 )
2015
43
Diffuse dermal angiomatosis associated with severe atherosclerosis: two cases and review of the literature. ( 25639294 )
2015
44
Diffuse dermal angiomatosis of the breast: Clinicopathologic study of 5 patients. ( 25264238 )
2014
45
Graft-versus-host disease-associated angiomatosis: a clinicopathologically distinct entity. ( 24993601 )
2014
46
Dental management in an encephalotrigeminal angiomatosis patient: a case report. ( 25284546 )
2014
47
Cutaneovisceral angiomatosis with thrombocytopenia without cutaneous involvement. ( 25088066 )
2014
48
Mediastinal angiomatosis. ( 25193206 )
2014
49
Sturge-Weber Syndrome (Encephalotrigeminal Angiomatosis): Recent Advances and Future Challenges. ( 26107979 )
2014
50
Tumoral bacillary angiomatosis in a child with human immunodeficiency virus. ( 25076357 )
2014

Variations for Angiomatosis

Expression for Angiomatosis

Search GEO for disease gene expression data for Angiomatosis.

Pathways for Angiomatosis

Pathways related to Angiomatosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.71 GNAQ TSC2

GO Terms for Angiomatosis

Biological processes related to Angiomatosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.16 GNAQ VHL
2 negative regulation of protein kinase activity GO:0006469 8.96 GNAQ TSC2
3 positive regulation of GTPase activity GO:0043547 8.8 CCL26 GNAQ TSC2

Sources for Angiomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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