MCID: ANG018
MIFTS: 46

Angiomyolipoma malady

Categories: Cancer diseases

Aliases & Classifications for Angiomyolipoma

Aliases & Descriptions for Angiomyolipoma:

Name: Angiomyolipoma 12 52 42 14 69
Angiomyolipoma of Kidney 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3314
MeSH 42 D018207
NCIt 47 C3734
SNOMED-CT 64 19929002
UMLS 69 C0206633

Summaries for Angiomyolipoma

Disease Ontology : 12 A cell type benign neoplasm that from perivascular epithelioid cells.

MalaCards based summary : Angiomyolipoma, also known as angiomyolipoma of kidney, is related to polycythemia and kidney angiomyolipoma. An important gene associated with Angiomyolipoma is TSC2 (Tuberous Sclerosis 2), and among its related pathways/superpathways are Glioma and PI3K-Akt signaling pathway. The drugs Afinitor and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and breast, and related phenotypes are cellular and behavior/neurological

Wikipedia : 71 Angiomyolipomas are the most common benign tumour of the kidney. Although regarded as benign,... more...

Related Diseases for Angiomyolipoma

Diseases related to Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
id Related Disease Score Top Affiliating Genes
1 polycythemia 29.4 MTOR PGR TSC1 TSC2
2 kidney angiomyolipoma 12.1
3 hepatic angiomyolipoma 12.0
4 childhood kidney angiomyolipoma 11.8
5 epithelioid type angiomyolipoma 11.8
6 tsc2 angiomyolipomas, renal, modifier of 11.7
7 lymphangioleiomyomatosis 11.2
8 tuberous sclerosis-1 10.8
9 multiple endocrine neoplasia 1 10.8
10 hepatitis 10.6
11 tuberous sclerosis 10.5
12 renal cell carcinoma 10.4
13 hemolytic anemia due to adenylate kinase deficiency 10.3 MTOR TSC1
14 melorheostosis with osteopoikilosis 10.3 TSC1 TSC2
15 oral erosive lichen 10.3 ACTC1 DES
16 renal tubular transport disease 10.3 TSC1 TSC2
17 vagina leiomyosarcoma 10.3 ACTC1 DES
18 osteomyelitis 10.2 ACTC1 DES
19 myoma 10.2 ACTC1 DES
20 congenital myasthenic syndrome 10.2 ACTC1 DES
21 adult endodermal sinus tumor 10.2 DES PGR
22 spleen angiosarcoma 10.2 ACTC1 DES
23 pericardium leiomyoma 10.2 ACTC1 PGR
24 hydrarthrosis 10.2 ACTC1 PGR
25 malignant dermis tumor 10.2 ACTC1 DES
26 urethral cancer 10.2 ACTC1 DES
27 radiation induced angiosarcoma of the breast 10.2 ACTC1 MTOR
28 mood disorder 10.2 KIT MTOR
29 pilocytic astrocytoma 10.2 MTOR TSC1 TSC2
30 testis sarcoma 10.2 DES KIT
31 bartholin's gland benign neoplasm 10.2 ESR1 PGR
32 pleomorphic xanthoastrocytoma 10.2 MTOR TSC1 TSC2
33 small intestinal vasoactive intestinal peptide producing tumor 10.2 DES ESR1
34 intestinal obstruction 10.2 ACTC1 DES
35 cardiovascular organ benign neoplasm 10.2 ESR1 PGR
36 auricular cancer 10.2 MTOR TSC1 TSC2
37 appendix leiomyoma 10.2 ESR1 PGR
38 bronchus adenoma 10.2 ESR1 PGR
39 glioma 10.2 ESR1 PGR
40 ovarian benign neoplasm 10.2 ESR1 PGR
41 plexiform neurofibroma 10.2 ESR1 PGR
42 paranasal sinus disease 10.2 ESR1 PGR
43 deafness, autosomal recessive 21 10.2 ESR1 PGR
44 polydactyly cleft lip palate psychomotor retardation 10.2 DES MTOR
45 gastrointestinal lymphoma 10.2 MTOR TSC1 TSC2
46 lymphomatous thyroiditis 10.2 DES PGR TSC2
47 cervical lymphoepithelioma-like carcinoma 10.2 ESR1 PGR
48 histiocytic and dendritic cell cancer 10.2 ESR1 PGR
49 pediatric intraocular retinoblastoma 10.2 ESR1 PGR
50 male urethral cancer 10.2 ACTC1 DES

Graphical network of the top 20 diseases related to Angiomyolipoma:



Diseases related to Angiomyolipoma

Symptoms & Phenotypes for Angiomyolipoma

MGI Mouse Phenotypes related to Angiomyolipoma:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.25 ACTC1 DES ESR1 KIT MITF MTOR
2 behavior/neurological MP:0005386 10.22 DES ESR1 KIT MITF MTOR PGR
3 cardiovascular system MP:0005385 10.21 ACTC1 DES ESR1 KIT MTOR PGR
4 homeostasis/metabolism MP:0005376 10.19 ACTC1 DES ESR1 KIT MITF MTOR
5 embryo MP:0005380 10.14 ESR1 KIT MITF MTOR PGR TSC1
6 endocrine/exocrine gland MP:0005379 10.13 ESR1 KIT MITF MTOR PGR TSC1
7 mortality/aging MP:0010768 10.13 ACTC1 DES ESR1 KIT MITF MTOR
8 growth/size/body region MP:0005378 10.11 ACTC1 ESR1 KIT MITF MTOR TSC1
9 integument MP:0010771 10.02 ESR1 KIT MITF PGR TSC1 TSC2
10 muscle MP:0005369 9.95 KIT MTOR PGR TSC1 ACTC1 DES
11 normal MP:0002873 9.86 ESR1 KIT MITF MTOR PGR TSC2
12 limbs/digits/tail MP:0005371 9.85 ESR1 KIT MITF PGR TYR
13 neoplasm MP:0002006 9.85 TYR ESR1 KIT PGR TSC1 TSC2
14 no phenotypic analysis MP:0003012 9.8 ESR1 KIT MITF MTOR PGR TYR
15 renal/urinary system MP:0005367 9.63 ESR1 KIT MTOR TSC1 TSC2 TYR
16 reproductive system MP:0005389 9.5 ESR1 KIT MITF PGR TSC1 TSC2
17 skeleton MP:0005390 9.17 KIT MITF MTOR PGR TSC1 TYR

Drugs & Therapeutics for Angiomyolipoma

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Afinitor 17 46 EVEROLIMUS Novartis Approved March 2009

Drugs for Angiomyolipoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
7 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antimalarials Phase 4
11 Antiparasitic Agents Phase 4
12 Antiprotozoal Agents Phase 4
13
Propranolol Approved, Investigational Phase 2 525-66-6 4946
14
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
15
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
16
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
17
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
18
Menthol Approved Phase 2 2216-51-5 16666
19 Adrenergic Agents Phase 2
20 Adrenergic Antagonists Phase 2
21 Adrenergic beta-Antagonists Phase 2
22 Angiogenesis Inhibitors Phase 2
23 Anti-Arrhythmia Agents Phase 2
24 Antihypertensive Agents Phase 2
25 Neurotransmitter Agents Phase 2
26 Vasodilator Agents Phase 2
27 Aromatase Inhibitors Phase 2
28 Estrogen Antagonists Phase 2
29 Estrogens Phase 2
30 Hormone Antagonists Phase 2
31 Hormones Phase 2
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
33 Steroid Synthesis Inhibitors Phase 2
34 Antineoplastic Agents, Hormonal Phase 2
35 Gastrointestinal Agents Phase 2
36 Analgesics Phase 2
37 Analgesics, Non-Narcotic Phase 2
38 Anti-Inflammatory Agents Phase 2
39 Anti-Inflammatory Agents, Non-Steroidal Phase 2
40 Antirheumatic Agents Phase 2
41 Cyclooxygenase 2 Inhibitors Phase 2
42 Cyclooxygenase Inhibitors Phase 2
43 Peripheral Nervous System Agents Phase 2
44 Liver Extracts Phase 2
45
saracatinib Phase 2
46 Cola Nutraceutical Phase 2

Interventional clinical trials:

(show all 19)
id Name Status NCT ID Phase
1 Rapamycin In Angiomyolipomas In Patients With Tuberous Sclerosis Completed NCT01217125 Phase 4
2 Doxycycline In Lymphangioleiomyomatosis (LAM) Completed NCT00989742 Phase 4
3 Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) Completed NCT00790400 Phase 3
4 Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers Unknown status NCT02104011 Phase 2
5 Sirolimus in Treating Patients With Angiomyolipoma of the Kidney Unknown status NCT00126672 Phase 2
6 Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM Unknown status NCT00490789 Phase 2
7 Single Arm Trial With Combination of Everolimus and Letrozole in Treatment of Platinum Resistant Relapse or Refractory or Persistent Ovarian Cancer/Endometrial Cancer Unknown status NCT02188550 Phase 2
8 RAD001 Therapy of Angiomyolipomata in Patients With TS Complex and Sporadic LAM Completed NCT00457964 Phase 1, Phase 2
9 Long Term Follow Up for RAD001 Therapy of Angiomyolipomata in Patients With Tuberous Sclerosis (TSC) and Sporadic Lymphangioleiomyomatosis (LAM) Completed NCT00792766 Phase 1, Phase 2
10 Rapamycin Therapy for Patients With Tuberous Sclerosis Complex and Sporadic LAM Completed NCT00457808 Phase 2
11 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2
12 Sporadic Angiomyolipomas (AMLs) Growth Kinetics While on Everolimus Recruiting NCT02539459 Phase 2
13 A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD Recruiting NCT02451696 Phase 2
14 COLA: A Pilot Clinical Trial of COX-2 Inhibition in LAM and TSC Recruiting NCT02484664 Phase 2
15 Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis Recruiting NCT02737202 Phase 2
16 A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa Withdrawn NCT01690871 Phase 2
17 Tuberous Sclerosis Complex Natural History Study: Renal Manifestations Completed NCT00598455
18 Characterization of Patients With Tuberous Sclerosis Complex, Lymphangioleiomyomatosis and Angiomyolipoma Recruiting NCT02325505
19 Clinical Presentation and Renal Outcome of Patients With Tuberous Sclerosis Complex and/or Renal Angiomyolipoma in the Great West Region of France Recruiting NCT02887781

Search NIH Clinical Center for Angiomyolipoma

Cochrane evidence based reviews: angiomyolipoma

Genetic Tests for Angiomyolipoma

Anatomical Context for Angiomyolipoma

MalaCards organs/tissues related to Angiomyolipoma:

39
Kidney, Liver, Breast, Lung, Endothelial, Colon, Smooth Muscle

Publications for Angiomyolipoma

Articles related to Angiomyolipoma:

(show top 50) (show all 779)
id Title Authors Year
1
Efficacy of Everolimus for Treating Renal Angiomyolipoma with Inferior Vena Cava Thrombus Associated with Tuberous Sclerosis: A Case Report. ( 28083476 )
2017
2
Spontaneous rupture of renal angiomyolipoma during pregnancy. ( 28062422 )
2017
3
Small (< 4 cm) Renal Tumors With Predominantly Low Signal Intensity on T2-Weighted Images: Differentiation of Minimal-Fat Angiomyolipoma From Renal Cell Carcinoma. ( 27824487 )
2017
4
Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors. ( 28053374 )
2017
5
Healthcare utilization and costs in patients with tuberous sclerosiscomplex-related renal angiomyolipoma. ( 27998195 )
2017
6
A hitherto undescribed benign mesenchymal polyp of the gallbladder: edematous angiomyolipoma-like polyp. ( 27821035 )
2016
7
Monoexponential, biexponential, and stretched exponential diffusion-weighted imaging models: Quantitative biomarkers for differentiating renal clear cell carcinoma and minimal fat angiomyolipoma. ( 27859853 )
2016
8
Laparoscopic Radiofrequency Ablation Combined with Surgical Excision for Exophytic Renal Angiomyolipoma: A Novel Technique Based on Tumor Vasculature Features of Enhancing Renal Masses Toward Hilar Off-Clamping Nephron-Sparing Surgery. ( 27805457 )
2016
9
Renal angiomyolipoma bleeding in a patient with TSC2/PKD1 contiguous gene syndrome after 17 years of renal replacement therapy. ( 27595512 )
2016
10
The Angiomyolipoma Conundrum. ( 27670990 )
2016
11
Re: Jaimin R. Bhatt, Patrick O. Richard, Nicole S. Kim, et al. Natural History of Renal Angiomyolipoma (AML): Most Patients with Large AMLs >4cm Can Be Offered Active Surveillance as an Initial Management Strategy. Eur Urol 2016;70:85-90. ( 27769715 )
2016
12
Re: Small (< 4 cm) Renal Masses: Differentiation of Angiomyolipoma without Visible Fat from Renal Cell Carcinoma Using Unenhanced and Contrast-Enhanced CT. ( 27186724 )
2016
13
Malignant hepatic epithelioid angiomyolipoma with recurrence in the lung 7A years after hepatectomy: a case report and literature review. ( 27037804 )
2016
14
Contrast-Enhanced Sonography and Fusion Technology for Assessment of an Embolized Renal Angiomyolipoma. ( 27672234 )
2016
15
Rapidly Progressing Malignant Epithelioid Renal Angiomyolipoma: A Case Report. ( 27085568 )
2016
16
The effects of everolimus on tuberous sclerosis complex-associated renal angiomyolipoma: a preliminary report. ( 27565896 )
2016
17
Angiomyolipoma of donor kidney: Successful transplantation and 5-year follow-up. ( 27051138 )
2016
18
An Unusual Variant of Hepatic Inflammatory Angiomyolipoma: Report of a Rare Entity. ( 26927347 )
2016
19
CT negative attenuation pixel distribution and texture analysis for detection of fat in small angiomyolipoma on unenhanced CT. ( 27015866 )
2016
20
Everolimus-induced near-resolution of giant cardiac rhabdomyomas and large renal angiomyolipoma in a newborn with tuberous sclerosis complex. ( 27055516 )
2016
21
Calcified Renal Angiomyolipoma: A Case Report. ( 27443470 )
2016
22
A Giant Intra Abdominal Mass Mimicking Renal Cell Carcinoma: A Rare Presentation of Renal Angiomyolipoma. ( 27612907 )
2016
23
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. ( 27248975 )
2016
24
An Unusual Combination of Biliary Cystadenoma and Renal Angiomyolipoma- A Case Report. ( 27437238 )
2016
25
Coexistence of pulmonary lymphangioleiomyomatosis and pulmonary angiomyolipoma. ( 27527652 )
2016
26
Activation of the ER stress and calcium signaling in angiomyolipoma. ( 27468872 )
2016
27
Evidence Supporting a Lymphatic Endothelium Origin for Angiomyolipoma, a TSC2(-) Tumor Related to Lymphangioleiomyomatosis. ( 27289491 )
2016
28
Angiomyolipoma of the rib: A rare case report. ( 26870370 )
2016
29
Long-Term Clinical Morbidity in Patients with Renal Angiomyolipoma Associated with Tuberous Sclerosis Complex. ( 27132503 )
2016
30
Successful Pregnancy Outcome in a Patient with Solitary Kidney Affected by Angiomyolipoma: A Rare Case. ( 27891407 )
2016
31
Renal Angiomyolipoma: Mid- to Long-Term Results Following Embolization with Onyx. ( 27468838 )
2016
32
Quantitative evaluation of contrast-enhanced ultrasound for differentiation of renal cell carcinoma subtypes and angiomyolipoma. ( 26971426 )
2016
33
Bilateral renal angiomyolipoma presenting as tuberous sclerosis syndrome. ( 26969365 )
2016
34
Treatment of renal angiomyolipoma in tuberous sclerosis complex (TSC) patients. ( 27585680 )
2016
35
Long-term outcome of robotic partial nephrectomy for renal angiomyolipoma. ( 27955873 )
2016
36
Re: Natural History of Renal Angiomyolipoma (AML): Most Patients with Large AMLs >4cm can be Offered Active Surveillance as an Initial Management Strategy. ( 27751445 )
2016
37
CD68-Positive Cells in Hepatic Angiomyolipoma. ( 28030864 )
2016
38
Not All Acute Abdomen Cases in Early Pregnancy Are Ectopic; Expect the Unexpected: Renal Angiomyolipoma Causing Massive Retroperitoneal Haemorrhage. ( 27429809 )
2016
39
Angiomyolipoma and Malignant PEComa: Discussion of Two Rare Adrenal Tumors. ( 26998374 )
2016
40
Editorial Comment to Outcomes of everolimus treatment for renal angiomyolipoma associated with tuberous sclerosis complex: A single institution experience in Japan. ( 27572892 )
2016
41
Lipid-poor renal angiomyolipoma: Differentiation from clear cell renal cell carcinoma using wash-in and washout characteristics on contrast-enhanced computed tomography. ( 26998171 )
2016
42
Re: Can Quantitative CT Texture Analysis be Used to Differentiate Fat-Poor Renal Angiomyolipoma from Renal Cell Carcinoma on Unenhanced CT Images? ( 27845102 )
2016
43
Small (<4 cm) Renal Mass: Differentiation of Angiomyolipoma without Visible Fat from Renal Cell Carcinoma Utilizing MR Imaging. ( 27429151 )
2016
44
Aneurysm in a Large Sporadic Renal Angiomyolipoma. ( 27162594 )
2016
45
Hemorrhagic Renal Angiomyolipoma in Pregnancy Effectively Managed by Immediate Cesarean Section and Elective Transcatheter Arterial Embolization: A Case Report. ( 27579420 )
2016
46
The impact of renal angiomyolipoma on estimated glomerular filtration rate in patients with tuberous sclerosis complex. ( 27710989 )
2016
47
A case of renal cell carcinoma and angiomyolipoma in an adolescent girl. ( 27499406 )
2016
48
Outcomes of everolimus treatment for renal angiomyolipoma associated with tuberous sclerosis complex: A single institution experience in Japan. ( 27480662 )
2016
49
A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma. ( 26989509 )
2016
50
Partial Nephrectomy for a Massive Sporadic Renal Angiomyolipoma: Case Report and Review of the Literature. ( 28070443 )
2016

Variations for Angiomyolipoma

Expression for Angiomyolipoma

Search GEO for disease gene expression data for Angiomyolipoma.

Pathways for Angiomyolipoma

Pathways related to Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 ESR1 KIT MITF MTOR PGR TSC1
2 12.29 KIT MTOR TSC1 TSC2
3
Show member pathways
12.09 KIT MTOR TSC1 TSC2
4 12.05 MTOR TSC1 TSC2
5
Show member pathways
11.98 MTOR TSC1 TSC2
6
Show member pathways
11.96 MTOR TSC1 TSC2
7
Show member pathways
11.91 MTOR TSC1 TSC2
8
Show member pathways
11.9 MTOR TSC1 TSC2
9 11.83 MTOR TSC1 TSC2
10 11.79 MTOR TSC1 TSC2
11 11.75 ESR1 MTOR TSC1 TSC2
12 11.74 ESR1 MTOR TSC2
13 11.7 MTOR TSC1 TSC2
14 11.54 MTOR TSC1 TSC2
15 11.33 MTOR TSC1 TSC2
16 11.22 MTOR TSC1 TSC2
17 11.08 MTOR TSC2
18 11.02 MTOR TSC2
19 10.86 MTOR TSC1 TSC2
20 10.79 MTOR TSC1
21 10.55 ESR1 MTOR TSC1 TSC2

GO Terms for Angiomyolipoma

Cellular components related to Angiomyolipoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC1 TSC2

Biological processes related to Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.63 MTOR TSC1 TSC2
2 positive regulation of gene expression GO:0010628 9.62 ACTC1 KIT MITF MTOR
3 stem cell differentiation GO:0048863 9.52 ESR1 KIT
4 negative regulation of TOR signaling GO:0032007 9.51 TSC1 TSC2
5 negative regulation of insulin receptor signaling pathway GO:0046627 9.49 TSC1 TSC2
6 positive regulation of macroautophagy GO:0016239 9.48 TSC1 TSC2
7 melanocyte differentiation GO:0030318 9.43 KIT MITF
8 regulation of osteoclast differentiation GO:0045670 9.4 MITF MTOR
9 negative regulation of macroautophagy GO:0016242 9.37 MTOR TSC1
10 anoikis GO:0043276 9.26 MTOR TSC2
11 negative regulation of cell size GO:0045792 9.16 MTOR TSC1
12 positive regulation of phospholipase C activity GO:0010863 8.96 ESR1 KIT
13 pigmentation GO:0043473 8.8 KIT MITF TYR

Molecular functions related to Angiomyolipoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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