MCID: ANG020
MIFTS: 49

Angiosarcoma malady

Cancer diseases, Rare diseases categories

Summaries for Angiosarcoma

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Disease Ontology:9 A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.

MalaCards based summary: Angiosarcoma, also known as hemangiosarcoma, is related to hemangioendothelioma and lymphedema. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Integrin cell surface interactions and S1P3 pathway. The compounds vegfc and vegfe have been mentioned in the context of this disorder. Affiliated tissues include breast, endothelial and liver, and related mouse phenotypes are respiratory system and liver/biliary system.

Wikipedia:63 Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may... more...

Aliases & Classifications for Angiosarcoma

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Sources:
9Disease Ontology, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Angiosarcoma, Aliases & Descriptions:

Name: Angiosarcoma 9 43 47
 
Hemangiosarcoma 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
angiosarcoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology9 DOID:0001816
NCIt38 C3088
MeSH33 D006394
Orphanet47 263413

Related Diseases for Angiosarcoma

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Diseases related to Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 257)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioendothelioma31.2FLT4
2lymphedema30.9VEGFC, FLT4
3breast cancer30.8VEGFC, KRT14
4epithelioid sarcoma30.3MUC1, CDH5
5kaposi sarcoma30.2PECAM1, VEGFC, KDR, FLT4
6hemangiopericytoma30.1MUC1, ACTC1
7malignant peripheral nerve sheath tumor30.1ACTC1, MUC1
8fibrous histiocytoma30.0SERPINA3, ACTC1
9hemangioma30.0PECAM1, KDR, FLT4, ANGPT2, ACTC1
10brain cancer29.9CDH5, ANGPT2, KDR, PECAM1
11gastrointestinal stromal tumor29.9ACTC1, KDR
12neurofibroma29.9ACTC1, MUC1
13ischemia29.8ANGPT2, KDR, VEGFC, PECAM1
14sarcoma29.8PECAM1, KDR, FLT4, MUC1, ANGPT2, ACTC1
15leiomyosarcoma29.7ACTC1, MUC1
16pyogenic granuloma29.7PECAM1, FLT4, ANGPT2, ACTC1
17mesothelioma29.7KRT14, ACTC1, MUC1, PECAM1
18adenoma29.5FLT4, MUC1, ANGPT2, ACTC1, KRT14
19melanoma28.0PECAM1, VEGFC, SERPINA3, KDR, FLT4, ANGPT2
20adenocarcinoma28.0CDH5, PECAM1, KRT14, ACTC1, ANGPT2, MUC1
21breast angiosarcoma10.7
22angiosarcoma of the scalp10.6
23hepatitis10.6
24liver angiosarcoma10.5
25endotheliitis10.5
26radiation induced angiosarcoma of the breast10.4
27ovarian angiosarcoma10.4
28ductal carcinoma in situ10.4KRT14
29cerebral cavernous malformations-110.4PECAM1, KDR
30thyroiditis10.4
31aneurysm10.4
32thyroid angiosarcoma10.4
33perineurioma10.3CDH5, MUC1
34thyroid carcinoma, follicular10.3VEGFC, KDR
35pediatric angiosarcoma10.3
36skin angiosarcoma10.3
37epithelioid hemangioendothelioma10.3
38hemangioma, capillary infantile10.3KDR, FLT4
39merkel cell carcinoma10.3KDR, MUC1
40hemangioblastoma10.3KDR, MUC1
41glomus tumor10.3ACTC1
42vascular cancer10.3KDR, FLT4
43spleen angiosarcoma10.3
44prostate angiosarcoma10.3
45lymphedema, congenital10.3FLT4, VEGFC
46uveal melanoma10.2CDH5, VEGFC
47lymphangiosarcoma10.2
48central nervous system angiosarcoma10.2
49conventional angiosarcoma10.2
50pericardial effusion10.2

Graphical network of the top 20 diseases related to Angiosarcoma:



Diseases related to angiosarcoma

Symptoms for Angiosarcoma

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Drugs & Therapeutics for Angiosarcoma

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Drug clinical trials:

Search ClinicalTrials for Angiosarcoma

Search NIH Clinical Center for Angiosarcoma

Genetic Tests for Angiosarcoma

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Anatomical Context for Angiosarcoma

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MalaCards organs/tissues related to Angiosarcoma:

31
Breast, Endothelial, Liver, Bone, Thyroid, Skin, Lung, Spleen, Heart, Ovary, Colon, Lymph node, Brain, Small intestine, Kidney, Adrenal gland, Bone marrow, Prostate, Pancreas, Uterus, Tongue, Cervix, Tonsil, T cells

Animal Models for Angiosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Angiosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9KRT14, ANGPT2, KDR, PECAM1
2MP:00053708.6PECAM1, KDR, FLT4, MUC1
3MP:00053918.5KDR, MUC1, ANGPT2, KRT14, CDH5
4MP:00053818.4PECAM1, FLT4, MUC1, ANGPT2, KRT14
5MP:00107718.1KDR, FLT4, MUC1, ANGPT2, KRT14, CDH5
6MP:00028737.9KDR, FLT4, MUC1, ACTC1, CDH5
7MP:00053877.8PECAM1, VEGFC, KDR, FLT4, ANGPT2, KRT14
8MP:00053857.6CDH5, PECAM1, VEGFC, KDR, FLT4, ANGPT2
9MP:00107687.2VEGFC, KDR, FLT4, ANGPT2, ACTC1, KRT14
10MP:00053766.9PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2

Publications for Angiosarcoma

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Articles related to Angiosarcoma:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast. (25864386)
2015
2
Angiosarcoma of penis: Case report of an aggressive penile cancer. (25837261)
2015
3
Case of malignant transformation of vagus nerve schwannoma to angiosarcoma. (23720355)
2014
4
Angiosarcoma of the scalp. (24367872)
2013
5
Metastatic epithelioid angiosarcoma to the mandible: report of a case and review of the literature. (23499149)
2013
6
Cardiac angiosarcoma: A paradigmatical case? (24200310)
2013
7
PET-guided biopsy with needle navigation facilitates diagnosis of angiosarcoma in neurofibromatosis type 1. (23922330)
2013
8
Angiosarcoma of the humerus presenting with fluid-fluid levels on MRI: a unique imaging presentation. (23722293)
2013
9
Nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis. (24349811)
2013
10
Irradiation-induced angiosarcoma and anti-angiogenic therapy: A therapeutic hope? (24384475)
2013
11
Expression of angiopoietin-TIE system components in angiosarcoma. (23558570)
2013
12
Angiosarcoma of penis. (24351513)
2013
13
Percutaneous coronary intervention for control of post-operative bleeding in patients with cardiac angiosarcoma. (23787245)
2013
14
A Rare Case of Primary Pulmonary Epithelioid Angiosarcoma Detected by 18F-FDG PET/CT. (23657141)
2013
15
Angiosarcoma with extensive pulmonary metastases, presenting with spontaneous bilateral pneumothoraces. (24032383)
2013
16
Angiosarcoma of the scalp successfully treated with a single therapy of sorafenib. (22710450)
2012
17
Epithelioid angiosarcoma arising in schwannoma: report of three Chinese cases with review of the literature. (22726071)
2012
18
Cytokeratin-positive epithelioid angiosarcoma presenting in the tonsil: a diagnostic challenge. (22406364)
2012
19
Colonic angiosarcoma: a rare cause of bleeding. (22507877)
2012
20
MRI findings of large low-grade angiosarcoma of the breast with subsequent bone metastases: a case report. (22807947)
2012
21
Cardiac angiosarcoma management and outcomes: 20-year single-institution experience. (22476752)
2012
22
Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient. (21752298)
2011
23
Angiosarcoma of the mandibular gingiva. (22135727)
2011
24
Cardiac angiosarcoma-associated membranoproliferative glomerulonephropathy. (21629818)
2011
25
Pathology quiz case 1. Angiosarcoma. (21339411)
2011
26
Primary breast angiosarcoma: avoiding a common trap. (22611503)
2011
27
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
28
Angiosarcoma mimicking a recurrent carotid artery aneurysm. (22023954)
2011
29
Synchronous bone marrow metastasis from primary splenic angiosarcoma. (21396272)
2010
30
Primary epithelioid angiosarcoma of the lung presenting as left-sided shoulder pain. (20838710)
2010
31
Gingival angiosarcoma mimicking necrotizing gingivitis. (20359867)
2010
32
Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma. (19836053)
2010
33
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
34
Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. (19696615)
2009
35
Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. (19008576)
2008
36
Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. (17720094)
2007
37
Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. (17667166)
2007
38
Primary ovarian angiosarcoma presenting as malignant cells in ascites: case report and review of the literature. (15830366)
2005
39
Primary left atrial angiosarcoma mimicking severe mitral valve stenosis. (15772176)
2005
40
A clinicopathological study of fifteen epithelioid angiosarcoma]. (12485481)
2002
41
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. (10964802)
2000
42
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
43
Mast cells in an angiosarcoma complicating xeroderma pigmentosum in a 13-year-old girl. (11044816)
2000
44
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. (9277092)
1996
45
Treatment of primary ovarian angiosarcoma with ifosfamide and doxorubicin. (8188092)
1994
46
Angiosarcoma of the heart causing cardiac rupture: a rare cause of hemopericardium. (8431074)
1993
47
Primary angiosarcoma of the heart causing cardiac rupture. (2741790)
1989
48
Two cases of liver angiosarcoma among polyvinyl chloride (PVC) extruders of an Italian factory producing PVC bags and other containers. (6539068)
1984
49
Canine angiosarcoma (lymphangiosarcoma). (7467082)
1981
50
Log normal distribution of the incubation period of liver angiosarcoma in vinyl chloride polymerization workers. (569691)
1979

Variations for Angiosarcoma

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Expression for genes affiliated with Angiosarcoma

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Search GEO for disease gene expression data for Angiosarcoma.

Pathways for genes affiliated with Angiosarcoma

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Pathways related to Angiosarcoma according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KDR, PECAM1
2
Show member pathways
S1P2 pathway36
S1P4 pathway36
S1P5 pathway36
S1P1 pathway36
Sphingosine 1-phosphate (S1P) pathway36
9.8KDR, CDH5
3
Show member pathways
9.6FLT4, KDR
4
Show member pathways
9.6VEGFC, FLT4
59.3CDH5, ACTC1
69.3KDR, ACTC1
7
Show member pathways
9.2FLT4, KDR, VEGFC
8
Show member pathways
9.2FLT4, KDR, VEGFC
9
Show member pathways
9.2FLT4, KDR, VEGFC
10
Show member pathways
9.2FLT4, KDR, VEGFC
11
Show member pathways
9.2FLT4, KDR, VEGFC
12
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.2VEGFC, KDR, FLT4
13
Show member pathways
9.2VEGFC, KDR, FLT4
14
Show member pathways
8.9VEGFC, KDR, FLT4, CDH5
15
Show member pathways
VEGFR1 specific signals36
8.9CDH5, FLT4, KDR, VEGFC
168.8ANGPT2, FLT4, KDR, VEGFC
17
Show member pathways
8.8ANGPT2, FLT4, KDR, VEGFC
18
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
198.8VEGFC, KDR, FLT4, ANGPT2
20
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
21
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
22
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
238.2CDH5, PECAM1, VEGFC, KDR, FLT4, ANGPT2
24
Show member pathways
8.0VEGFC, KDR, FLT4, MUC1, ANGPT2, CDH5

Compounds for genes affiliated with Angiosarcoma

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Compounds related to Angiosarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1vegfc2810.0FLT4, KDR
2vegfe2810.0FLT4, KDR
3azd 21714310.0FLT4, KDR
4zd6474439.9KDR, FLT4
5axitinib59 43 1211.9FLT4, KDR
6su5416439.9FLT4, KDR
7fucoidan439.8KDR, PECAM1
8pazopanib49 1210.8FLT4, KDR
9sunitinib43 49 1211.7KDR, FLT4
10progestin439.6KDR, MUC1, ANGPT2
11regorafenib49 1210.6FLT4, KDR
12lutein439.6ANGPT2, SERPINA3
13s 100439.5ACTC1, MUC1
14agar439.5MUC1, KDR, PECAM1
15reticulin439.4ACTC1, MUC1
162-methoxyethanol439.4KRT14, ACTC1
17sialic acid439.4PECAM1, SERPINA3, MUC1
18trastuzumab43 49 1211.3VEGFC, KDR, MUC1, ANGPT2
19folate439.3SERPINA3, KDR, MUC1
20hydrocortisone43 2 59 1212.2KDR, MUC1, KRT14, CDH5
21fibrinogen439.2CDH5, ANGPT2, SERPINA3, PECAM1
22ly294002439.2VEGFC, KDR, FLT4, ANGPT2
23formaldehyde43 2410.2PECAM1, MUC1, ACTC1
24heparin43 28 24 1212.1KDR, SERPINA3, VEGFC, PECAM1
25polysaccharide439.1SERPINA3, KDR, MUC1, CDH5
26mucicarmine439.1KRT14, ACTC1, MUC1
27estradiol43 24 1211.1CDH5, MUC1, SERPINA3, VEGFC
28thymidine43 2410.0PECAM1, VEGFC, KDR, MUC1, ANGPT2
29cyclosporin a43 28 5910.9ACTC1, ANGPT2, KDR, PECAM1
30hematoxylin438.8PECAM1, MUC1, ACTC1, KRT14
31cholesterol43 28 24 1211.8PECAM1, SERPINA3, MUC1, KRT14
32phosphatidylinositol438.7CDH5, ANGPT2, KDR, VEGFC
33nitric oxide43 24 1210.7PECAM1, VEGFC, KDR, MUC1, ANGPT2, CDH5
34arginine438.6SERPINA3, KDR, KRT14, CDH5
35creatinine438.5SERPINA3, MUC1, ANGPT2, ACTC1
36lipid438.3PECAM1, VEGFC, SERPINA3, MUC1, KRT14, CDH5
37cysteine438.2PECAM1, SERPINA3, KDR, MUC1, ANGPT2, KRT14
38ribonucleic acid438.2PECAM1, VEGFC, MUC1, ANGPT2, ACTC1, CDH5
39serine438.2PECAM1, SERPINA3, KDR, MUC1, ANGPT2, KRT14
40progesterone43 28 59 24 1212.1VEGFC, SERPINA3, MUC1, ACTC1, KRT14
41matrigel437.4PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
42vegf437.4PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
43dexamethasone43 49 28 1210.4VEGFC, SERPINA3, KDR, FLT4, MUC1, ANGPT2
44oxygen43 248.1PECAM1, VEGFC, SERPINA3, FLT4, MUC1, ANGPT2
45glucose437.1PECAM1, VEGFC, SERPINA3, MUC1, ANGPT2, ACTC1
46calcium43 49 24 1210.1PECAM1, VEGFC, SERPINA3, MUC1, ANGPT2, ACTC1
47tyrosine436.8PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
48estrogen436.5PECAM1, VEGFC, SERPINA3, KDR, FLT4, MUC1
49retinoic acid43 247.5PECAM1, VEGFC, SERPINA3, KDR, FLT4, MUC1
50paraffin436.2CDH5, PECAM1, VEGFC, KRT14, ACTC1, ANGPT2

GO Terms for genes affiliated with Angiosarcoma

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Cellular components related to Angiosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:00300549.5CDH5, KDR, PECAM1
2extracellular spaceGO:00056158.3ACTC1, ANGPT2, VEGFC, PECAM1
3extracellular regionGO:00055768.2ANGPT2, FLT4, KDR, SERPINA3, VEGFC
4extracellular vesicular exosomeGO:00700627.7PECAM1, SERPINA3, MUC1, ACTC1, KRT14

Biological processes related to Angiosarcoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:00019459.8FLT4, KDR
2cellular response to vascular endothelial growth factor stimulusGO:00359249.8KDR, FLT4
3positive regulation of endothelial cell migrationGO:00105959.7KDR, FLT4
4transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.6FLT4, KDR
5positive regulation of MAPK cascadeGO:00434109.5FLT4, KDR
6angiogenesisGO:00015259.5ANGPT2, KDR, VEGFC
7vascular endothelial growth factor receptor signaling pathwayGO:00480109.4FLT4, KDR, VEGFC
8positive regulation of endothelial cell proliferationGO:00019389.3KDR, FLT4
9positive regulation of cell proliferationGO:00082849.2FLT4, KDR, VEGFC

Molecular functions related to Angiosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:00199039.6CDH5, FLT4
2vascular endothelial growth factor-activated receptor activityGO:00050219.6FLT4, KDR
3growth factor bindingGO:00198389.5KDR, FLT4
4transmembrane receptor protein tyrosine kinase activityGO:00047149.3FLT4, KDR
5protein bindingGO:00055156.7CDH5, PECAM1, VEGFC, SERPINA3, KDR, FLT4

Products for genes affiliated with Angiosarcoma

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Sources for Angiosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet