MCID: ANG020
MIFTS: 60

Angiosarcoma malady

Cancer diseases, Rare diseases categories
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Summaries for Angiosarcoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.

MalaCards: Angiosarcoma, also known as hemangiosarcoma, is related to hemangioendothelioma and lymphedema. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Integrin cell surface interactions and S1P3 pathway. The compounds vegfc and vegfe have been mentioned in the context of this disorder. Affiliated tissues include breast, endothelial and liver, and related mouse phenotypes are respiratory system and liver/biliary system.

Wikipedia:65 Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may... more...

Aliases & Classifications for Angiosarcoma

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8Disease Ontology, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
angiosarcoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

angiosarcoma 8 45 49
hemangiosarcoma 8 62
hemangioendothelioma, malignant 8
malignant hemangioendothelioma 45
primary hemangiosarcoma 8


External Ids:

Disease Ontology8 DOID:0001816
NCIt40 C3088
MeSH35 D006394
SNOMED-CT via Orphanet59 403977003, 39000009

Related Diseases for Angiosarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Angiosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioendothelioma30.7FLT4
2lymphedema30.6VEGFC, FLT4
3sarcoma30.4PECAM1, KDR, FLT4, MUC1, ANGPT2, ACTC1
4hemangioma30.3PECAM1, KDR, FLT4, ANGPT2, ACTC1
5kaposi's sarcoma30.3PECAM1, VEGFC, KDR, FLT4
6breast cancer30.1PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
7hemangiopericytoma30.0MUC1, ACTC1
8malignant peripheral nerve sheath tumor30.0ACTC1, MUC1
9fibrous histiocytoma30.0SERPINA3, ACTC1
10pyogenic granuloma29.9PECAM1, FLT4, ANGPT2, ACTC1
11epithelioid sarcoma29.9MUC1, CDH5
12adenoma29.8FLT4, MUC1, ANGPT2, ACTC1, KRT14
13brain cancer29.8CDH5, ANGPT2, KDR, PECAM1
14gastrointestinal stromal tumor29.8ACTC1, KDR
15neurofibroma29.8ACTC1, MUC1
16ischemia29.8ANGPT2, KDR, VEGFC, PECAM1
17cervical cancer29.8KRT14, FLT4, VEGFC
18leiomyosarcoma29.8ACTC1, MUC1
19ovarian cancer29.7VEGFC, KDR, FLT4, MUC1
20adenocarcinoma29.5CDH5, PECAM1, KRT14, ACTC1, ANGPT2, MUC1
21melanoma29.3PECAM1, VEGFC, SERPINA3, KDR, FLT4, ANGPT2
22breast angiosarcoma10.6
23angiosarcoma of the scalp10.6
24liver angiosarcoma10.5
25hepatitis10.5
26endotheliitis10.4
27aneurysm10.4
28ovarian angiosarcoma10.3
29radiation induced angiosarcoma of the breast10.3
30thyroiditis10.3
31epithelioid hemangioendothelioma10.3
32pediatric angiosarcoma10.3
33thyroid angiosarcoma10.3
34skin angiosarcoma10.3
35xeroderma pigmentosum10.3
36spleen angiosarcoma10.2
37prostate angiosarcoma10.2
38pericardial effusion10.2
39lymphangiosarcoma10.2
40conventional angiosarcoma10.2
41teratoma10.2
42cardiac tamponade10.1
43duodenitis10.1
44central nervous system angiosarcoma10.1
45aorta angiosarcoma10.1
46gallbladder angiosarcoma10.1
47superior vena cava angiosarcoma10.1
48mediastinum angiosarcoma10.1
49cerebritis10.1
50cervicitis10.1

Graphical network of the top 20 diseases related to Angiosarcoma:



Diseases related to angiosarcoma

Symptoms for Angiosarcoma

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Drugs & Therapeutics for Angiosarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Angiosarcoma

Search NIH Clinical Center for Angiosarcoma

Genetic Tests for Angiosarcoma

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Anatomical Context for Angiosarcoma

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33MalaCards
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MalaCards organs/tissues related to Angiosarcoma:

33
Breast, Endothelial, Liver, Bone, Lung, Skin, Spleen, Thyroid, Heart, Ovary, Colon, Adrenal gland, Kidney, Small intestine, Lymph node, Prostate, Bone marrow, Uterus, Pancreas, Brain, Tongue, Cervix, T cells

Animal Models for Angiosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Angiosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9KRT14, ANGPT2, KDR, PECAM1
2MP:00053708.6PECAM1, KDR, FLT4, MUC1
3MP:00053918.5KDR, MUC1, ANGPT2, KRT14, CDH5
4MP:00053818.4PECAM1, FLT4, MUC1, ANGPT2, KRT14
5MP:00107718.1KDR, FLT4, MUC1, ANGPT2, KRT14, CDH5
6MP:00028737.9KDR, FLT4, MUC1, ACTC1, CDH5
7MP:00053877.8PECAM1, VEGFC, KDR, FLT4, ANGPT2, KRT14
8MP:00053857.6CDH5, PECAM1, VEGFC, KDR, FLT4, ANGPT2
9MP:00107687.2VEGFC, KDR, FLT4, ANGPT2, ACTC1, KRT14
10MP:00053766.9PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2

Publications for Angiosarcoma

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Sources:
52PubMed
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Articles related to Angiosarcoma:

(show top 50)    (show all 678)
idTitleAuthorsYear
1
Case of malignant transformation of vagus nerve schwannoma to angiosarcoma. (23720355)
2014
2
Angiosarcoma of the scalp. (24367872)
2013
3
Metastatic epithelioid angiosarcoma to the mandible: report of a case and review of the literature. (23499149)
2013
4
Cardiac angiosarcoma: A paradigmatical case? (24200310)
2013
5
PET-guided biopsy with needle navigation facilitates diagnosis of angiosarcoma in neurofibromatosis type 1. (23922330)
2013
6
Angiosarcoma of the humerus presenting with fluid-fluid levels on MRI: a unique imaging presentation. (23722293)
2013
7
Nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis. (24349811)
2013
8
Irradiation-induced angiosarcoma and anti-angiogenic therapy: A therapeutic hope? (24384475)
2013
9
Expression of angiopoietin-TIE system components in angiosarcoma. (23558570)
2013
10
Angiosarcoma of penis. (24351513)
2013
11
Percutaneous coronary intervention for control of post-operative bleeding in patients with cardiac angiosarcoma. (23787245)
2013
12
A Rare Case of Primary Pulmonary Epithelioid Angiosarcoma Detected by 18F-FDG PET/CT. (23657141)
2013
13
Angiosarcoma with extensive pulmonary metastases, presenting with spontaneous bilateral pneumothoraces. (24032383)
2013
14
Rupture of splenic angiosarcoma: a rare cause of spontaneous haemoperitoneum. (23709556)
2013
15
Angiosarcoma of the scalp successfully treated with a single therapy of sorafenib. (22710450)
2012
16
Epithelioid angiosarcoma arising in schwannoma: report of three Chinese cases with review of the literature. (22726071)
2012
17
Colonic angiosarcoma: a rare cause of bleeding. (22507877)
2012
18
MRI findings of large low-grade angiosarcoma of the breast with subsequent bone metastases: a case report. (22807947)
2012
19
Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy. (21997379)
2012
20
Cardiac angiosarcoma management and outcomes: 20-year single-institution experience. (22476752)
2012
21
Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient. (21752298)
2011
22
Angiosarcoma of the mandibular gingiva. (22135727)
2011
23
Cardiac angiosarcoma-associated membranoproliferative glomerulonephropathy. (21629818)
2011
24
Pathology quiz case 1. Angiosarcoma. (21339411)
2011
25
Primary breast angiosarcoma: avoiding a common trap. (22611503)
2011
26
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
27
Angiosarcoma mimicking a recurrent carotid artery aneurysm. (22023954)
2011
28
Synchronous bone marrow metastasis from primary splenic angiosarcoma. (21396272)
2010
29
Primary epithelioid angiosarcoma of the lung presenting as left-sided shoulder pain. (20838710)
2010
30
Gingival angiosarcoma mimicking necrotizing gingivitis. (20359867)
2010
31
Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma. (19836053)
2010
32
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
33
Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. (19696615)
2009
34
Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. (19008576)
2008
35
Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. (17720094)
2007
36
Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. (17667166)
2007
37
Primary ovarian angiosarcoma presenting as malignant cells in ascites: case report and review of the literature. (15830366)
2005
38
Primary left atrial angiosarcoma mimicking severe mitral valve stenosis. (15772176)
2005
39
A clinicopathological study of fifteen epithelioid angiosarcoma]. (12485481)
2002
40
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. (10964802)
2000
41
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
42
Mast cells in an angiosarcoma complicating xeroderma pigmentosum in a 13-year-old girl. (11044816)
2000
43
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. (9277092)
1996
44
Treatment of primary ovarian angiosarcoma with ifosfamide and doxorubicin. (8188092)
1994
45
Angiosarcoma of the heart causing cardiac rupture: a rare cause of hemopericardium. (8431074)
1993
46
Primary angiosarcoma of the heart causing cardiac rupture. (2741790)
1989
47
Two cases of liver angiosarcoma among polyvinyl chloride (PVC) extruders of an Italian factory producing PVC bags and other containers. (6539068)
1984
48
Canine angiosarcoma (lymphangiosarcoma). (7467082)
1981
49
Log normal distribution of the incubation period of liver angiosarcoma in vinyl chloride polymerization workers. (569691)
1979
50
Intravascular angiomatosis: development and distinction from angiosarcoma. (1237350)
1975

Variations for Angiosarcoma

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Expression for genes affiliated with Angiosarcoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiosarcoma

Search GEO for disease gene expression data for Angiosarcoma.

Pathways for genes affiliated with Angiosarcoma

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 61Tocris Bioscience, 60Thomson Reuters, 53QIAGEN, 57SinoBiological, 30KEGG, 5Cell Signaling Technology
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Pathways related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KDR, PECAM1
2
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.8KDR, CDH5
3
Show member pathways
9.6FLT4, KDR
4
Show member pathways
9.6VEGFC, FLT4
59.3CDH5, ACTC1
69.3KDR, ACTC1
7
Show member pathways
9.2FLT4, KDR, VEGFC
8
Show member pathways
9.2FLT4, KDR, VEGFC
9
Show member pathways
9.2FLT4, KDR, VEGFC
10
Show member pathways
9.2FLT4, KDR, VEGFC
11
Show member pathways
9.2FLT4, KDR, VEGFC
12
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
9.2VEGFC, KDR, FLT4
13
Show member pathways
9.2VEGFC, KDR, FLT4
14
Show member pathways
8.9VEGFC, KDR, FLT4, CDH5
15
Show member pathways
VEGFR1 specific signals38
8.9CDH5, FLT4, KDR, VEGFC
168.8ANGPT2, FLT4, KDR, VEGFC
17
Show member pathways
8.8ANGPT2, FLT4, KDR, VEGFC
18
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
198.8VEGFC, KDR, FLT4, ANGPT2
20
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
21
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
22
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
238.2CDH5, PECAM1, VEGFC, KDR, FLT4, ANGPT2
24
Show member pathways
8.0VEGFC, KDR, FLT4, MUC1, ANGPT2, CDH5

Compounds for genes affiliated with Angiosarcoma

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Sources:
29IUPHAR, 45Novoseek, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 3BitterDB, 24HMDB
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Compounds related to Angiosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1vegfc2910.0FLT4, KDR
2vegfe2910.0FLT4, KDR
3azd 21714510.0FLT4, KDR
4zd6474459.9KDR, FLT4
5axitinib61 45 1111.9FLT4, KDR
6su5416459.9FLT4, KDR
7fucoidan459.8KDR, PECAM1
8pazopanib51 1110.8FLT4, KDR
9sunitinib45 51 1111.7KDR, FLT4
10progestin459.6KDR, MUC1, ANGPT2
11regorafenib51 1110.6FLT4, KDR
12lutein459.6ANGPT2, SERPINA3
13s 100459.5ACTC1, MUC1
14agar459.5MUC1, KDR, PECAM1
15reticulin459.4ACTC1, MUC1
162-methoxyethanol459.4KRT14, ACTC1
17sialic acid459.4PECAM1, SERPINA3, MUC1
18trastuzumab45 51 1111.3VEGFC, KDR, MUC1, ANGPT2
19folate459.3SERPINA3, KDR, MUC1
20hydrocortisone45 3 61 1112.2KDR, MUC1, KRT14, CDH5
21fibrinogen459.2CDH5, ANGPT2, SERPINA3, PECAM1
22ly294002459.2VEGFC, KDR, FLT4, ANGPT2
23formaldehyde45 2410.2PECAM1, MUC1, ACTC1
24heparin45 29 24 1112.1KDR, SERPINA3, VEGFC, PECAM1
25polysaccharide459.1SERPINA3, KDR, MUC1, CDH5
26mucicarmine459.1KRT14, ACTC1, MUC1
27estradiol45 24 1111.1CDH5, MUC1, SERPINA3, VEGFC
28thymidine45 2410.0PECAM1, VEGFC, KDR, MUC1, ANGPT2
29cyclosporin a45 29 6110.9ACTC1, ANGPT2, KDR, PECAM1
30hematoxylin458.8PECAM1, MUC1, ACTC1, KRT14
31cholesterol45 29 24 1111.8PECAM1, SERPINA3, MUC1, KRT14
32phosphatidylinositol458.7CDH5, ANGPT2, KDR, VEGFC
33nitric oxide45 24 1110.7PECAM1, VEGFC, KDR, MUC1, ANGPT2, CDH5
34arginine458.6SERPINA3, KDR, KRT14, CDH5
35creatinine458.5SERPINA3, MUC1, ANGPT2, ACTC1
36lipid458.3PECAM1, VEGFC, SERPINA3, MUC1, KRT14, CDH5
37cysteine458.2PECAM1, SERPINA3, KDR, MUC1, ANGPT2, KRT14
38ribonucleic acid458.2PECAM1, VEGFC, MUC1, ANGPT2, ACTC1, CDH5
39serine458.2PECAM1, SERPINA3, KDR, MUC1, ANGPT2, KRT14
40progesterone45 29 61 24 1112.1VEGFC, SERPINA3, MUC1, ACTC1, KRT14
41matrigel457.4PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
42vegf457.4PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
43dexamethasone45 51 29 1110.4VEGFC, SERPINA3, KDR, FLT4, MUC1, ANGPT2
44oxygen45 248.1PECAM1, VEGFC, SERPINA3, FLT4, MUC1, ANGPT2
45glucose457.1PECAM1, VEGFC, SERPINA3, MUC1, ANGPT2, ACTC1
46calcium45 51 24 1110.1PECAM1, VEGFC, SERPINA3, MUC1, ANGPT2, ACTC1
47tyrosine456.8PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
48estrogen456.5PECAM1, VEGFC, SERPINA3, KDR, FLT4, MUC1
49retinoic acid45 247.5PECAM1, VEGFC, SERPINA3, KDR, FLT4, MUC1
50paraffin456.2CDH5, PECAM1, VEGFC, KRT14, ACTC1, ANGPT2

GO Terms for genes affiliated with Angiosarcoma

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16Gene Ontology
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Cellular components related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:0300549.5CDH5, KDR, PECAM1
2extracellular spaceGO:0056158.3ACTC1, ANGPT2, VEGFC, PECAM1
3extracellular regionGO:0055768.2ANGPT2, FLT4, KDR, SERPINA3, VEGFC
4extracellular vesicular exosomeGO:0700627.7PECAM1, SERPINA3, MUC1, ACTC1, KRT14

Biological processes related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:0019459.8FLT4, KDR
2cellular response to vascular endothelial growth factor stimulusGO:0359249.8KDR, FLT4
3positive regulation of endothelial cell migrationGO:0105959.7KDR, FLT4
4transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.6FLT4, KDR
5positive regulation of MAPK cascadeGO:0434109.5FLT4, KDR
6angiogenesisGO:0015259.5ANGPT2, KDR, VEGFC
7vascular endothelial growth factor receptor signaling pathwayGO:0480109.4FLT4, KDR, VEGFC
8positive regulation of endothelial cell proliferationGO:0019389.3KDR, FLT4
9positive regulation of cell proliferationGO:0082849.2FLT4, KDR, VEGFC

Molecular functions related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.6CDH5, FLT4
2vascular endothelial growth factor-activated receptor activityGO:0050219.6FLT4, KDR
3growth factor bindingGO:0198389.5KDR, FLT4
4transmembrane receptor protein tyrosine kinase activityGO:0047149.3FLT4, KDR
5protein bindingGO:0055156.7CDH5, PECAM1, VEGFC, SERPINA3, KDR, FLT4

Products for genes affiliated with Angiosarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angiosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet