MCID: ANG020
MIFTS: 61

Angiosarcoma malady

Cancer diseases category

Summaries for Angiosarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.

MalaCards: Angiosarcoma, also known as hemangiosarcoma, is related to sarcoma and lymphedema. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Tyrosine Kinases / Adaptors and VEGF Signaling Pathway. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include breast, endothelial and liver, and related mouse phenotypes are muscle and integument.

Wikipedia:63 Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may... more...

Aliases & Classifications for Angiosarcoma

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
angiosarcoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

angiosarcoma 8 44 48
hemangiosarcoma 8 60
hemangioendothelioma, malignant 8
malignant hemangioendothelioma 44
primary hemangiosarcoma 8


External Ids:

Disease Ontology8 DOID:0001816
NCIt39 C3088
MeSH34 D006394
SNOMED-CT via Orphanet57 403977003, 39000009

Related Diseases for Angiosarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Angiosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.5FLI1, CALB2, VIM, FLT4, ANGPT2, MUC1
2lymphedema30.4VEGFC, PROX1, FLT4, PDPN
3hemangioma30.4PECAM1, ACTC1, KDR, CD34, ANGPT2, PROX1
4breast cancer30.3VEGFC, PROX1, FLT4, FLI1, PDPN, TIE1
5kaposi's sarcoma30.2PDPN, FLI1, FLT4, VEGFC, CD34, KDR
6lymphangiosarcoma30.2PROX1
7squamous cell carcinoma30.2KRT14, KDR, FSCN1, CD34, MUC1, ANGPT2
8thrombocytopenia30.1FLI1, CD34, PECAM1
9lipoma30.0CD34
10fibrous histiocytoma29.9CD34
11hemangiopericytoma29.9VIM, MUC1, CD34, ACTC1
12epithelioid sarcoma29.9VIM, CALB2, MUC1, CDH5, CD34
13epithelioid hemangioendothelioma29.9FLT4, CD34
14adenoma29.9ACTC1, KRT14, FSCN1, MUC1, ANGPT2, FLT4
15malignant peripheral nerve sheath tumor29.9VIM, CALB2, CD34
16adenocarcinoma29.9VIM, TIE1, CALB2, PDPN, FLI1, PECAM1
17adenosarcoma29.9ACTC1
18liposarcoma29.8CD34, FLI1, CALB2, VIM
19fibrosarcoma29.8ACTC1, CD34, VIM
20colon cancer29.8CALB2, FLT4, FSCN1, KDR
21peritonitis29.7PECAM1
22cystadenoma29.7VEGFC
23hemangioendothelioma29.7CD34, FLT4, FLI1
24cystadenocarcinoma29.7MUC1
25leiomyoma29.7ACTC1, CD34, VIM
26gastrointestinal stromal tumor29.7ACTC1, KDR, CD34, VIM
27ischemia29.7TIE1, VEGFC, ANGPT2, KDR, PECAM1
28neurofibroma29.7VIM, MUC1, CD34, ACTC1
29peripheral primitive neuroectodermal tumor29.7FLI1
30papillary carcinoma29.7CALB2, VEGFC, MUC1, KRT14, ACTC1
31cervical cancer29.7KRT14, VEGFC, FLT4, PDPN
32malignant mesothelioma29.7VIM, CALB2, PDPN, FLT4, MUC1, KDR
33leiomyosarcoma29.7ACTC1, CD34, MUC1, CALB2, VIM
34malignant pleural mesothelioma29.7CALB2
35chondrosarcoma29.7SERPINA3, MUC1, VIM
36lymphangioleiomyomatosis29.7VEGFC
37ovarian cancer29.7CALB2, FLT4, VEGFC, MUC1, FSCN1, KDR
38brain cancer29.7ANGPT2, CDH5, KDR, PECAM1
39melanoma29.7PECAM1, SERPINA3, ACTC1, FLT4, VEGFC, ANGPT2
40cutaneous fibrous histiocytoma29.7CD34
41transitional cell carcinoma29.7KRT14, VEGFC, CALB2
42pneumonia29.7MUC1, VEGFC
43breast angiosarcoma10.7
44liver angiosarcoma10.6
45hepatitis10.4
46ovarian angiosarcoma10.4
47skin angiosarcoma10.4
48spleen angiosarcoma10.4
49thyroid angiosarcoma10.3
50hepatitis a10.3

Graphical network of the top 20 diseases related to Angiosarcoma:



Diseases related to angiosarcoma

Clinical Features for Angiosarcoma

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Drugs & Therapeutics for Angiosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angiosarcoma

Drug clinical trials:

Search ClinicalTrials for Angiosarcoma

Search NIH Clinical Center for Angiosarcoma

Search CenterWatch for Angiosarcoma

Genetic Tests for Angiosarcoma

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Anatomical Context for Angiosarcoma

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32MalaCards
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MalaCards organs/tissues related to Angiosarcoma:

32
Breast, Endothelial, Liver, Bone, Lung, Skin, Spleen, Thyroid, Heart, Ovary, Colon, Small intestine, Adrenal gland, Lymph node, Kidney, Prostate, Bone marrow, Uterus, Pancreas, Brain, Tongue, Cervix, Tonsil, T cells

Animal Models for Angiosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiosarcoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.6TIE1, FLI1, KDR, SLC6A6, ACTC1
2MP:001077110.6TIE1, ANGPT2, CD34, KDR, KRT14
3MP:000537610.6PDPN, PROX1, CD34, SLC6A6, KRT14, ACTC1
4MP:000538510.5PECAM1, VIM, TIE1, PDPN, FLI1, FLT4
5MP:000538110.5TIE1, PDPN, FLT4, PROX1, ANGPT2, MUC1
6MP:000539110.5VIM, PROX1, ANGPT2, MUC1, SLC6A6, KRT14
7MP:000538710.4PROX1, FLT4, FLI1, PDPN, TIE1, VIM
8MP:000537010.4FLT4, PROX1, MUC1, KDR, PECAM1, FLI1
9MP:000538410.3VIM, TIE1, FLI1, PROX1, CDH5, CD34
10MP:000538810.3TIE1, PDPN, PROX1, KDR, KRT14, PECAM1
11MP:001076810.3FLT4, FLI1, PDPN, TIE1, VIM, PROX1
12MP:000537810.0VIM, TIE1, PDPN, FLI1, FLT4, PROX1

Publications for Angiosarcoma

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50PubMed
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Articles related to Angiosarcoma:

(show top 50)    (show all 684)
idTitleAuthorsYear
1
Angiosarcoma of the corpora cavernosa. (24405295)
2014
2
Angiosarcoma after breast-conserving therapy: Long-term disease control and late effects with hyperfractionated accelerated re-irradiation (HART). (24345278)
2014
3
Angiosarcoma of the scalp successfully treated with pazopanib. (24176520)
2014
4
Breakages at YWHAE, FAM22A, and FAM22B loci in uterine angiosarcoma: A case report with immunohistochemical and genetic analysis. (24125656)
2014
5
Cutaneous angiosarcoma of the scalp mimicking a keratoacanthoma. (24011315)
2013
6
Unresectable Angiosarcoma Treated With Bevacizumab and Paclitaxel. (24144236)
2013
7
Through the looking glass: primary epithelioid angiosarcoma in the left atrium, a unique site for a rare malignancy. (23331275)
2013
8
Computed tomography and magnetic resonance imaging findings of primary bladder angiosarcoma: a case report. (24361175)
2013
9
An Unusual Malignant Thyroid Nodule: Coexistence of Epithelioid Angiosarcoma and Follicular Variant Papillary Thyroid Carcinoma. (23608996)
2013
10
Fine-Needle aspiration cytology of primary renal angiosarcoma with histopathologic and immunocytochemical correlation: A Case Report. (24166896)
2013
11
Sporadic versus Radiation-Associated Angiosarcoma: A Comparative Clinicopathologic and Molecular Analysis of 48 Cases. (24082817)
2013
12
Angiosarcoma presenting with minor erythema and swelling. (23616765)
2013
13
Small intestinal angiosarcoma masquerading as an appendiceal abscess. (23317721)
2013
14
Right atrial rupture in angiosarcoma. (23542097)
2013
15
Multifocal epithelioid angiosarcoma of bone with lung metastases. (22560236)
2012
16
Oropharyngeal metastasis of cardiogenic angiosarcoma. (22214640)
2012
17
Cutaneous angiosarcoma masquerading as herpes zoster. (22908732)
2012
18
Hepatic angiosarcoma mimicking sinusoidal obstruction syndrome/venoocclusive disease: a pathologic-radiologic correlation. (22304789)
2012
19
Angiosarcoma of the proximal humerus: a case report and review of the literature. (23050518)
2012
20
Angiosarcoma in recurrent malignant phyllodes tumor of breast. (22771666)
2012
21
Primary low-grade angiosarcoma of the cervical lymph node. (22935182)
2012
22
Granular cell angiosarcoma. (22515218)
2012
23
Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report. (22280556)
2012
24
Cutaneous epithelioid angiosarcoma: a rare aggressive neoplasm. (22772625)
2012
25
Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient. (21752298)
2011
26
Cardiac angiosarcoma-associated membranoproliferative glomerulonephropathy. (21629818)
2011
27
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
28
Angiosarcoma mimicking a recurrent carotid artery aneurysm. (22023954)
2011
29
Histological differentiation, histogenesis and prognosis of cutaneous angiosarcoma. (22106765)
2011
30
Angiosarcoma of the forearm arising in an arteriovenous fistula in a renal transplant recipient. (21700540)
2011
31
Intra-arterial mitoxantrone/paclitaxel in angiosarcoma of the lower limb associated with chronic lymphedema (Stewart-Treves syndrome) in a patient with cervical cancer. (21233070)
2011
32
A first case of hepatic angiosarcoma treated with recombinant interleukin-2. (22389954)
2011
33
Epithelioid angiosarcoma of the bladder: report of a new case with immunohistochemical profile and review of the literature. (21436648)
2011
34
Angiosarcoma of the scalp with complete response to a biweekly gemcitabine and docetaxel (GEMDOC) chemotherapy regimen. (21229496)
2011
35
Primary epithelioid angiosarcoma of the lung presenting as left-sided shoulder pain. (20838710)
2010
36
Endomyocardial biopsy of right atrial angiosarcoma guided by intracardiac echocardiography. (20585357)
2010
37
Primary angiosarcoma of the breast after pregnancy. (21513627)
2010
38
Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy. (20162708)
2010
39
Antiproliferative effects of rapamycin and celecoxib in angiosarcoma cell lines. (21036716)
2010
40
Breast angiosarcoma metastatic to the ovary. (19718246)
2009
41
Cutaneous angiosarcoma after breast conserving treatment for bilateral breast cancers in a BRCA-1 gene mutation carrier--a case report and review of the literature. (19736894)
2009
42
Angiosarcoma of the pericardium presenting as hemorrhagic pleuropericarditis, cardiac tamponade, and thromboembolic phenomena. (16904210)
2007
43
Vascular tumors of bone: A study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcoma. (12874764)
2003
44
Diffuse liver angiosarcoma and cerebral cavernous angiomas in a young patient. (10692780)
1999
45
Podoplanin--a specific marker for lymphatic endothelium expressed in angiosarcoma]. (10714221)
1999
46
Cutaneous angiosarcoma with thrombocytopenia. (10321640)
1999
47
Primary renal epithelioid angiosarcoma with transitional cell carcinoma in renal pelvis]. (10374567)
1997
48
A case of breast angiosarcoma: diagnostic imaging and review of the literature. (8804460)
1995
49
Treatment of primary ovarian angiosarcoma with ifosfamide and doxorubicin. (8188092)
1994
50
Neurofibrosarcoma of the radial nerve in von Recklinghausen's disease with metastatic angiosarcoma. (96219)
1978

Genetic Variations for Angiosarcoma

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Expression for genes affiliated with Angiosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiosarcoma

Search GEO for disease gene expression data for Angiosarcoma.

Pathways for genes affiliated with Angiosarcoma

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Sources:
4Cell Signaling Technology, 49PharmGKB, 55SinoBiological, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Angiosarcoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9CALB2
2dexamethasone44 49 28 1113.9KDR, ANGPT2, VEGFC
3reticulin4410.8VIM, MUC1, CD34, ACTC1
4s 1004410.8VIM, MUC1, ACTC1
5ribonucleic acid4410.8VEGFC, ANGPT2, MUC1, CDH5, ACTC1, PECAM1
6vegfe2810.8FLT4, KDR
7sialic acid4410.8PECAM1
8trastuzumab44 49 1112.8VEGFC, ANGPT2, MUC1, KDR
9mucicarmine4410.8VIM, CALB2, MUC1, KRT14, ACTC1
102-methoxyethanol4410.8ACTC1, KRT14, VIM
11vegfc2810.8FLT4, KDR
12hydrocortisone44 2 59 1113.8VIM, MUC1, CDH5, KDR, KRT14
13b 7234410.8ACTC1, MUC1, PDPN, CALB2, VIM
14matrigel4410.8FLT4, VEGFC, ANGPT2, MUC1, CDH5, KDR
15glucose4410.8VEGFC, ANGPT2, MUC1, CDH5, KRT14, ACTC1
16azd 21714410.8FLT4, KDR
17progestin4410.8KDR, MUC1, ANGPT2, VIM
18serine4410.8PECAM1, SERPINA3, KRT14, SLC6A6, FSCN1
19oxygen44 2411.8FLT4, VEGFC, ANGPT2, MUC1, CDH5, SERPINA3
20thymidine44 2411.8CALB2, VEGFC, ANGPT2, MUC1, CD34, KDR
21agar4410.8VIM, MUC1, CD34, KDR, PECAM1
22hematoxylin4410.8PECAM1, ACTC1, KRT14, CD34, MUC1, PDPN
23nitric oxide44 11 2412.7TIE1, CALB2, VEGFC, ANGPT2, MUC1, CDH5
24polysaccharide4410.7SERPINA3, KDR, CDH5, MUC1, PDPN
25progesterone44 59 28 11 2414.7VIM, CALB2, VEGFC, MUC1, CD34, KRT14
26formaldehyde44 2411.7PECAM1, ACTC1, MUC1, VIM
27orcein4410.7ACTC1, VIM
28folate4410.7SERPINA3, KDR, MUC1, VIM
29estradiol44 11 2412.7VIM, VEGFC, MUC1, CDH5, SERPINA3
30cysteine4410.7VIM, ANGPT2, MUC1, KDR, SLC6A6, KRT14
31retinoic acid44 2411.7PECAM1, VIM, FLT4, VEGFC, ANGPT2, MUC1
32creatinine4410.7ANGPT2, ACTC1, SERPINA3
33vegf4410.7VIM, TIE1, PDPN, FLT4, PECAM1, ACTC1
34eosin4410.7MUC1, VIM
35heparin44 28 11 2413.7PECAM1, SERPINA3
36zd64744410.7FLT4, KDR
37calcium44 49 11 2413.7CALB2, VEGFC, ANGPT2, MUC1, CDH5, FSCN1
38lipid4410.7VIM, VEGFC, MUC1, CDH5, KRT14, SERPINA3
39tyrosine4410.6ANGPT2, VEGFC, FLT4, PDPN, CALB2, TIE1
40paraffin4410.6PECAM1, VIM, CALB2, PDPN, FLT4, VEGFC
41axitinib44 59 1112.6KDR, FLT4
4212-o-tetradecanoylphorbol 13-acetate4410.6FSCN1, CD34, MUC1, VIM
43butyrate4410.6CALB2
44silver4410.5CALB2, CD34, SERPINA3
45tamoxifen44 49 28 1113.5KRT14, KDR, MUC1, VIM
46rapamycin4410.4PECAM1, KDR, FLT4, VIM
47paclitaxel44 49 1112.4CALB2, FLT4, KDR
48fibrinogen4410.3PECAM1, SERPINA3, CDH5, ANGPT2
49testosterone44 59 11 2413.1VIM, CALB2, VEGFC, MUC1, ACTC1

GO Terms for genes affiliated with Angiosarcoma

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16Gene Ontology
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Cellular components related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.3SLC6A6, KDR, CD34, MUC1, FLT4, PDPN

Biological processes related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor signaling pathwayGO:04801010.7FLT4, VEGFC, KDR
2lymphangiogenesisGO:00194610.7PROX1, FLT4, PDPN
3positive regulation of endothelial cell migrationGO:01059510.7KDR, PROX1, FLT4
4glomerular endothelium developmentGO:07201110.7CD34, PECAM1
5endothelium developmentGO:00315810.6CD34, KDR
6skeletal muscle thin filament assemblyGO:03024010.6ACTC1, PROX1
7positive regulation of endothelial cell proliferationGO:00193810.6KDR, PROX1, FLT4
8angiogenesisGO:00152510.5TIE1, VEGFC, ANGPT2, KDR
9lymph vessel developmentGO:00194510.5KDR, FLT4
10positive regulation of vasculogenesisGO:200121410.4KDR, CD34
11leukocyte migrationGO:05090010.4PECAM1, CD34, ANGPT2
12signal transductionGO:00716510.3TIE1, PDPN, VEGFC, ANGPT2, CD34, PECAM1
13positive regulation of angiogenesisGO:04576610.1KDR, CD34, ANGPT2

Molecular functions related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:00502110.4KDR, FLT4
2transmembrane receptor protein tyrosine kinase activityGO:00471410.3KDR, FLT4, TIE1
3protein bindingGO:0055159.9VIM, TIE1, FLT4, PROX1, VEGFC, ANGPT2

Products for genes affiliated with Angiosarcoma

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Sources for Angiosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet