MCID: ANG020
MIFTS: 60

Angiosarcoma malady

Cancer diseases, Rare diseases categories
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Summaries for Angiosarcoma

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Disease Ontology:8 A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.

MalaCards based summary: Angiosarcoma, also known as primary hemangiosarcoma, is related to hemangioendothelioma and lymphedema. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Integrin cell surface interactions and S1P3 pathway. The compounds vegfe and vegfc have been mentioned in the context of this disorder. Affiliated tissues include breast, endothelial and liver, and related mouse phenotypes are respiratory system and liver/biliary system.

Wikipedia:65 Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may... more...

Aliases & Classifications for Angiosarcoma

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Sources:
8Disease Ontology, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
See all sources

Angiosarcoma, Aliases & Descriptions:

Name: Angiosarcoma 8 44 48
Primary Hemangiosarcoma 8 62
Hemangiosarcoma 8 62
 
Haemangioendothelioma, Malignant 62
Hemangioendothelioma, Malignant 8
Malignant Hemangioendothelioma 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
angiosarcoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:0001816
MeSH34 D006394
NCIt39 C3088

Related Diseases for Angiosarcoma

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Diseases related to Angiosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioendothelioma31.2FLT4
2lymphedema30.9VEGFC, FLT4
3kaposi's sarcoma30.3PECAM1, VEGFC, KDR, FLT4
4epithelioid sarcoma30.3MUC1, CDH5
5hemangiopericytoma30.1MUC1, ACTC1
6fibrous histiocytoma30.0SERPINA3, ACTC1
7hemangioma30.0PECAM1, KDR, FLT4, ANGPT2, ACTC1
8brain cancer29.9CDH5, ANGPT2, KDR, PECAM1
9gastrointestinal stromal tumor29.9ACTC1, KDR
10malignant peripheral nerve sheath tumor29.9ACTC1, MUC1
11neurofibroma29.9ACTC1, MUC1
12ischemia29.8ANGPT2, KDR, VEGFC, PECAM1
13sarcoma29.8PECAM1, KDR, FLT4, MUC1, ANGPT2, ACTC1
14cervical cancer29.8KRT14, FLT4, VEGFC
15leiomyosarcoma29.8ACTC1, MUC1
16pyogenic granuloma29.7PECAM1, FLT4, ANGPT2, ACTC1
17ovarian cancer29.7VEGFC, KDR, FLT4, MUC1
18adenoma29.5FLT4, MUC1, ANGPT2, ACTC1, KRT14
19breast cancer29.4PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
20melanoma28.1PECAM1, VEGFC, SERPINA3, KDR, FLT4, ANGPT2
21adenocarcinoma28.0CDH5, PECAM1, KRT14, ACTC1, ANGPT2, MUC1
22breast angiosarcoma10.6
23angiosarcoma of the scalp10.6
24liver angiosarcoma10.5
25hepatitis10.5
26endotheliitis10.5
27radiation induced angiosarcoma of the breast10.4
28ductal carcinoma in situ10.4KRT14
29cerebral cavernous malformation10.4PECAM1, KDR
30ovarian angiosarcoma10.4
31aneurysm10.4
32thyroiditis10.4
33perineurioma10.3CDH5, MUC1
34follicular thyroid carcinoma10.3VEGFC, KDR
35thyroid angiosarcoma10.3
36skin angiosarcoma10.3
37epithelioid hemangioendothelioma10.3
38hemangioma, capillary infantile10.3KDR, FLT4
39merkel cell carcinoma10.3KDR, MUC1
40hemangioblastoma10.3KDR, MUC1
41paraganglioma10.3ACTC1
42vascular cancer10.3KDR, FLT4
43lymphedema, congenital10.3FLT4, VEGFC
44lymphangiosarcoma10.3
45pediatric angiosarcoma10.3
46xeroderma pigmentosum10.3
47uveal melanoma10.3CDH5, VEGFC
48breast cancer, invasive ductal10.2VEGFC, KRT14
49spleen angiosarcoma10.2
50prostate angiosarcoma10.2

Graphical network of the top 20 diseases related to Angiosarcoma:



Diseases related to angiosarcoma

Symptoms for Angiosarcoma

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Drugs & Therapeutics for Angiosarcoma

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Drug clinical trials:

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Genetic Tests for Angiosarcoma

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Anatomical Context for Angiosarcoma

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MalaCards organs/tissues related to Angiosarcoma:

32
Breast, Endothelial, Liver, Bone, Skin, Lung, Thyroid, Spleen, Heart, Ovary, Colon, Lymph node, Brain, Small intestine, Kidney, Adrenal gland, Bone marrow, Prostate, Pancreas, Uterus, Tongue, Cervix, Tonsil, T cells

Animal Models for Angiosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Angiosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9KRT14, PECAM1, KDR, ANGPT2
2MP:00053708.6KDR, FLT4, MUC1, PECAM1
3MP:00053918.5CDH5, KRT14, ANGPT2, MUC1, KDR
4MP:00053818.4PECAM1, FLT4, MUC1, ANGPT2, KRT14
5MP:00107718.1KRT14, CDH5, ANGPT2, MUC1, FLT4, KDR
6MP:00028737.9MUC1, KDR, CDH5, ACTC1, FLT4
7MP:00053877.8FLT4, PECAM1, VEGFC, KDR, ANGPT2, KRT14
8MP:00053857.6ANGPT2, PECAM1, VEGFC, KDR, FLT4, ACTC1
9MP:00107687.2KDR, KRT14, ACTC1, ANGPT2, CDH5, FLT4
10MP:00053766.9ANGPT2, ACTC1, KRT14, MUC1, FLT4, KDR

Publications for Angiosarcoma

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Articles related to Angiosarcoma:

(show top 50)    (show all 718)
idTitleAuthorsYear
1
Case of malignant transformation of vagus nerve schwannoma to angiosarcoma. (23720355)
2014
2
Angiosarcoma of the scalp. (24367872)
2013
3
Metastatic epithelioid angiosarcoma to the mandible: report of a case and review of the literature. (23499149)
2013
4
Cardiac angiosarcoma: A paradigmatical case? (24200310)
2013
5
PET-guided biopsy with needle navigation facilitates diagnosis of angiosarcoma in neurofibromatosis type 1. (23922330)
2013
6
Angiosarcoma of the humerus presenting with fluid-fluid levels on MRI: a unique imaging presentation. (23722293)
2013
7
Nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis. (24349811)
2013
8
Irradiation-induced angiosarcoma and anti-angiogenic therapy: A therapeutic hope? (24384475)
2013
9
Expression of angiopoietin-TIE system components in angiosarcoma. (23558570)
2013
10
Angiosarcoma of penis. (24351513)
2013
11
Percutaneous coronary intervention for control of post-operative bleeding in patients with cardiac angiosarcoma. (23787245)
2013
12
A Rare Case of Primary Pulmonary Epithelioid Angiosarcoma Detected by 18F-FDG PET/CT. (23657141)
2013
13
Angiosarcoma with extensive pulmonary metastases, presenting with spontaneous bilateral pneumothoraces. (24032383)
2013
14
Rupture of splenic angiosarcoma: a rare cause of spontaneous haemoperitoneum. (23709556)
2013
15
Angiosarcoma of the scalp successfully treated with a single therapy of sorafenib. (22710450)
2012
16
Epithelioid angiosarcoma arising in schwannoma: report of three Chinese cases with review of the literature. (22726071)
2012
17
Cytokeratin-positive epithelioid angiosarcoma presenting in the tonsil: a diagnostic challenge. (22406364)
2012
18
Colonic angiosarcoma: a rare cause of bleeding. (22507877)
2012
19
MRI findings of large low-grade angiosarcoma of the breast with subsequent bone metastases: a case report. (22807947)
2012
20
Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy. (21997379)
2012
21
Cardiac angiosarcoma management and outcomes: 20-year single-institution experience. (22476752)
2012
22
Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient. (21752298)
2011
23
Angiosarcoma of the mandibular gingiva. (22135727)
2011
24
Cardiac angiosarcoma-associated membranoproliferative glomerulonephropathy. (21629818)
2011
25
Pathology quiz case 1. Angiosarcoma. (21339411)
2011
26
Primary breast angiosarcoma: avoiding a common trap. (22611503)
2011
27
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
28
Angiosarcoma mimicking a recurrent carotid artery aneurysm. (22023954)
2011
29
Synchronous bone marrow metastasis from primary splenic angiosarcoma. (21396272)
2010
30
Primary epithelioid angiosarcoma of the lung presenting as left-sided shoulder pain. (20838710)
2010
31
Gingival angiosarcoma mimicking necrotizing gingivitis. (20359867)
2010
32
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
33
Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. (19696615)
2009
34
Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. (19008576)
2008
35
Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. (17720094)
2007
36
Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. (17667166)
2007
37
Primary ovarian angiosarcoma presenting as malignant cells in ascites: case report and review of the literature. (15830366)
2005
38
Primary left atrial angiosarcoma mimicking severe mitral valve stenosis. (15772176)
2005
39
A clinicopathological study of fifteen epithelioid angiosarcoma]. (12485481)
2002
40
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. (10964802)
2000
41
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
42
Mast cells in an angiosarcoma complicating xeroderma pigmentosum in a 13-year-old girl. (11044816)
2000
43
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. (9277092)
1996
44
Treatment of primary ovarian angiosarcoma with ifosfamide and doxorubicin. (8188092)
1994
45
Angiosarcoma of the heart causing cardiac rupture: a rare cause of hemopericardium. (8431074)
1993
46
Primary angiosarcoma of the heart causing cardiac rupture. (2741790)
1989
47
Two cases of liver angiosarcoma among polyvinyl chloride (PVC) extruders of an Italian factory producing PVC bags and other containers. (6539068)
1984
48
Canine angiosarcoma (lymphangiosarcoma). (7467082)
1981
49
Log normal distribution of the incubation period of liver angiosarcoma in vinyl chloride polymerization workers. (569691)
1979
50
Intravascular angiomatosis: development and distinction from angiosarcoma. (1237350)
1975

Variations for Angiosarcoma

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Expression for genes affiliated with Angiosarcoma

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Expression patterns in normal tissues for genes affiliated with Angiosarcoma

Search GEO for disease gene expression data for Angiosarcoma.

Pathways for genes affiliated with Angiosarcoma

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Pathways related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PECAM1, KDR
2
Show member pathways
S1P2 pathway37
S1P4 pathway37
S1P5 pathway37
S1P1 pathway37
Sphingosine 1-phosphate (S1P) pathway37
9.8CDH5, KDR
3
Show member pathways
9.6FLT4, KDR
4
Show member pathways
9.6FLT4, VEGFC
59.3CDH5, ACTC1
69.3ACTC1, KDR
7
Show member pathways
9.2FLT4, VEGFC, KDR
8
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.2FLT4, KDR, VEGFC
9
Show member pathways
9.2KDR, VEGFC, FLT4
10
Show member pathways
9.2FLT4, KDR, VEGFC
11
Show member pathways
9.2KDR, FLT4, VEGFC
12
Show member pathways
9.2KDR, FLT4, VEGFC
13
Show member pathways
9.2VEGFC, KDR, FLT4
14
Show member pathways
VEGFR1 specific signals37
8.9KDR, FLT4, CDH5, VEGFC
15
Show member pathways
8.9KDR, VEGFC, CDH5, FLT4
16
Show member pathways
8.8FLT4, KDR, VEGFC, ANGPT2
178.8FLT4, KDR, VEGFC, ANGPT2
18
Show member pathways
8.8FLT4, VEGFC, KDR, ANGPT2
19
Show member pathways
8.8ANGPT2, KDR, FLT4, VEGFC
20
Show member pathways
8.8FLT4, VEGFC, KDR, ANGPT2
218.8ANGPT2, FLT4, KDR, VEGFC
22
Show member pathways
8.8VEGFC, ANGPT2, KDR, FLT4
238.2PECAM1, VEGFC, KDR, FLT4, ANGPT2, CDH5
24
Show member pathways
8.0VEGFC, KDR, FLT4, MUC1, CDH5, ANGPT2

Compounds for genes affiliated with Angiosarcoma

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Compounds related to Angiosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1vegfe2810.0FLT4, KDR
2vegfc2810.0KDR, FLT4
3azd 21714410.0KDR, FLT4
4zd6474449.9FLT4, KDR
5axitinib61 44 1111.9FLT4, KDR
6su5416449.9FLT4, KDR
7fucoidan449.8KDR, PECAM1
8pazopanib50 1110.8FLT4, KDR
9sunitinib44 50 1111.7KDR, FLT4
10progestin449.6ANGPT2, MUC1, KDR
11regorafenib50 1110.6KDR, FLT4
12lutein449.6ANGPT2, SERPINA3
13s 100449.5ACTC1, MUC1
14agar449.5MUC1, PECAM1, KDR
15reticulin449.4MUC1, ACTC1
162-methoxyethanol449.4ACTC1, KRT14
17sialic acid449.4PECAM1, SERPINA3, MUC1
18trastuzumab44 50 1111.3ANGPT2, MUC1, KDR, VEGFC
19folate449.3KDR, MUC1, SERPINA3
20hydrocortisone44 2 61 1112.2MUC1, CDH5, KRT14, KDR
21fibrinogen449.2PECAM1, SERPINA3, CDH5, ANGPT2
22ly294002449.2ANGPT2, FLT4, KDR, VEGFC
23formaldehyde44 2410.2PECAM1, ACTC1, MUC1
24heparin44 28 24 1112.1SERPINA3, KDR, PECAM1, VEGFC
25polysaccharide449.1CDH5, MUC1, KDR, SERPINA3
26mucicarmine449.1KRT14, ACTC1, MUC1
27estradiol44 24 1111.1CDH5, VEGFC, MUC1, SERPINA3
28thymidine44 2410.0VEGFC, KDR, MUC1, ANGPT2, PECAM1
29cyclosporin a44 28 6110.9ANGPT2, ACTC1, KDR, PECAM1
30hematoxylin448.8ACTC1, MUC1, PECAM1, KRT14
31cholesterol44 28 24 1111.8KRT14, PECAM1, MUC1, SERPINA3
32phosphatidylinositol448.7VEGFC, ANGPT2, KDR, CDH5
33nitric oxide44 24 1110.7MUC1, CDH5, PECAM1, VEGFC, KDR, ANGPT2
34arginine448.6SERPINA3, KDR, KRT14, CDH5
35creatinine448.5ACTC1, SERPINA3, MUC1, ANGPT2
36lipid448.3VEGFC, SERPINA3, MUC1, KRT14, CDH5, PECAM1
37cysteine448.2MUC1, ANGPT2, SERPINA3, PECAM1, KRT14, KDR
38ribonucleic acid448.2PECAM1, VEGFC, MUC1, ANGPT2, ACTC1, CDH5
39serine448.2KDR, SERPINA3, PECAM1, KRT14, MUC1, ANGPT2
40progesterone44 28 61 24 1112.1VEGFC, SERPINA3, MUC1, ACTC1, KRT14
41matrigel447.4CDH5, MUC1, PECAM1, VEGFC, KDR, FLT4
42vegf447.4PECAM1, VEGFC, KDR, MUC1, ANGPT2, ACTC1
43dexamethasone44 50 28 1110.4ANGPT2, FLT4, KDR, SERPINA3, VEGFC, ACTC1
44oxygen44 248.1FLT4, PECAM1, SERPINA3, VEGFC, MUC1, ANGPT2
45glucose447.1CDH5, KRT14, ACTC1, SERPINA3, ANGPT2, MUC1
46calcium44 50 24 1110.1SERPINA3, VEGFC, PECAM1, MUC1, KRT14, CDH5
47tyrosine446.8VEGFC, FLT4, MUC1, ANGPT2, ACTC1, KRT14
48estrogen446.5VEGFC, PECAM1, ACTC1, SERPINA3, FLT4, MUC1
49retinoic acid44 247.5KRT14, SERPINA3, KDR, FLT4, MUC1, ANGPT2
50paraffin446.2ACTC1, ANGPT2, MUC1, FLT4, KDR, SERPINA3

GO Terms for genes affiliated with Angiosarcoma

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Cellular components related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:0300549.5CDH5, KDR, PECAM1
2extracellular spaceGO:0056158.3ACTC1, ANGPT2, VEGFC, PECAM1
3extracellular regionGO:0055768.2ANGPT2, FLT4, KDR, SERPINA3, VEGFC
4extracellular vesicular exosomeGO:0700627.7PECAM1, SERPINA3, MUC1, ACTC1, KRT14

Biological processes related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:0019459.8FLT4, KDR
2cellular response to vascular endothelial growth factor stimulusGO:0359249.8KDR, FLT4
3positive regulation of endothelial cell migrationGO:0105959.7KDR, FLT4
4transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.6FLT4, KDR
5positive regulation of MAPK cascadeGO:0434109.5FLT4, KDR
6angiogenesisGO:0015259.5ANGPT2, KDR, VEGFC
7vascular endothelial growth factor receptor signaling pathwayGO:0480109.4FLT4, KDR, VEGFC
8positive regulation of endothelial cell proliferationGO:0019389.3KDR, FLT4
9positive regulation of cell proliferationGO:0082849.2FLT4, KDR, VEGFC

Molecular functions related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.6CDH5, FLT4
2vascular endothelial growth factor-activated receptor activityGO:0050219.6FLT4, KDR
3growth factor bindingGO:0198389.5KDR, FLT4
4transmembrane receptor protein tyrosine kinase activityGO:0047149.3FLT4, KDR
5protein bindingGO:0055156.7CDH5, PECAM1, VEGFC, SERPINA3, KDR, FLT4

Products for genes affiliated with Angiosarcoma

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  • Antibodies
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Sources for Angiosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet