MCID: ANG020
MIFTS: 60

Angiosarcoma malady

Cancer diseases, Rare diseases categories

Summaries for Angiosarcoma

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.

MalaCards: Angiosarcoma, also known as hemangiosarcoma, is related to hemangioendothelioma and lymphedema. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Integrin cell surface interactions and S1P3 pathway. The compounds vegfc and vegfe have been mentioned in the context of this disorder. Affiliated tissues include breast, endothelial and liver, and related mouse phenotypes are respiratory system and liver/biliary system.

Wikipedia:66 Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may... more...

Aliases & Classifications for Angiosarcoma

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Sources:
9Disease Ontology, 46Novoseek, 50Orphanet, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 60SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 50 
Rare tumors


Characteristics (Orphanet epidemiological data):

50
angiosarcoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

angiosarcoma 9 46 50
hemangiosarcoma 9 63
hemangioendothelioma, malignant 9
malignant hemangioendothelioma 46
primary hemangiosarcoma 9


External Ids:

Disease Ontology9 DOID:0001816
NCIt41 C3088
MeSH36 D006394
SNOMED-CT via Orphanet60 403977003, 39000009

Related Diseases for Angiosarcoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Angiosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioendothelioma30.7FLT4
2lymphedema30.6VEGFC, FLT4
3sarcoma30.4PECAM1, KDR, FLT4, MUC1, ANGPT2, ACTC1
4hemangioma30.3PECAM1, KDR, FLT4, ANGPT2, ACTC1
5kaposi's sarcoma30.3PECAM1, VEGFC, KDR, FLT4
6breast cancer30.1PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
7hemangiopericytoma30.0MUC1, ACTC1
8malignant peripheral nerve sheath tumor30.0ACTC1, MUC1
9fibrous histiocytoma30.0SERPINA3, ACTC1
10pyogenic granuloma29.9PECAM1, FLT4, ANGPT2, ACTC1
11epithelioid sarcoma29.9MUC1, CDH5
12adenoma29.8FLT4, MUC1, ANGPT2, ACTC1, KRT14
13brain cancer29.8CDH5, ANGPT2, KDR, PECAM1
14gastrointestinal stromal tumor29.8ACTC1, KDR
15neurofibroma29.8ACTC1, MUC1
16ischemia29.8ANGPT2, KDR, VEGFC, PECAM1
17cervical cancer29.8KRT14, FLT4, VEGFC
18leiomyosarcoma29.8ACTC1, MUC1
19ovarian cancer29.7VEGFC, KDR, FLT4, MUC1
20adenocarcinoma29.5CDH5, PECAM1, KRT14, ACTC1, ANGPT2, MUC1
21melanoma29.3PECAM1, VEGFC, SERPINA3, KDR, FLT4, ANGPT2
22breast angiosarcoma10.6
23angiosarcoma of the scalp10.6
24liver angiosarcoma10.5
25hepatitis10.5
26endotheliitis10.4
27aneurysm10.4
28ovarian angiosarcoma10.3
29radiation induced angiosarcoma of the breast10.3
30thyroiditis10.3
31epithelioid hemangioendothelioma10.3
32pediatric angiosarcoma10.3
33thyroid angiosarcoma10.3
34skin angiosarcoma10.3
35xeroderma pigmentosum10.3
36spleen angiosarcoma10.2
37prostate angiosarcoma10.2
38pericardial effusion10.2
39lymphangiosarcoma10.2
40conventional angiosarcoma10.2
41teratoma10.2
42cardiac tamponade10.1
43duodenitis10.1
44central nervous system angiosarcoma10.1
45aorta angiosarcoma10.1
46gallbladder angiosarcoma10.1
47superior vena cava angiosarcoma10.1
48mediastinum angiosarcoma10.1
49cerebritis10.1
50cervicitis10.1

Graphical network of the top 20 diseases related to Angiosarcoma:



Diseases related to angiosarcoma

Symptoms for Angiosarcoma

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Drugs & Therapeutics for Angiosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Angiosarcoma

Drug clinical trials:

Search ClinicalTrials for Angiosarcoma

Search NIH Clinical Center for Angiosarcoma

Search CenterWatch for Angiosarcoma

Genetic Tests for Angiosarcoma

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Anatomical Context for Angiosarcoma

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34MalaCards
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MalaCards organs/tissues related to Angiosarcoma:

34
Breast, Endothelial, Liver, Bone, Lung, Skin, Spleen, Thyroid, Heart, Ovary, Colon, Adrenal gland, Kidney, Small intestine, Lymph node, Prostate, Bone marrow, Uterus, Pancreas, Brain, Tongue, Cervix, T cells

Animal Models for Angiosarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Angiosarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.9KRT14, ANGPT2, KDR, PECAM1
2MP:00053708.6PECAM1, KDR, FLT4, MUC1
3MP:00053918.5KDR, MUC1, ANGPT2, KRT14, CDH5
4MP:00053818.4PECAM1, FLT4, MUC1, ANGPT2, KRT14
5MP:00107718.1KDR, FLT4, MUC1, ANGPT2, KRT14, CDH5
6MP:00028737.9KDR, FLT4, MUC1, ACTC1, CDH5
7MP:00053877.8PECAM1, VEGFC, KDR, FLT4, ANGPT2, KRT14
8MP:00053857.6CDH5, PECAM1, VEGFC, KDR, FLT4, ANGPT2
9MP:00107687.2VEGFC, KDR, FLT4, ANGPT2, ACTC1, KRT14
10MP:00053766.9PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2

Publications for Angiosarcoma

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Sources:
53PubMed
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Articles related to Angiosarcoma:

(show top 50)    (show all 678)
idTitleAuthorsYear
1
Case of malignant transformation of vagus nerve schwannoma to angiosarcoma. (23720355)
2014
2
Angiosarcoma of the scalp. (24367872)
2013
3
Metastatic epithelioid angiosarcoma to the mandible: report of a case and review of the literature. (23499149)
2013
4
Cardiac angiosarcoma: A paradigmatical case? (24200310)
2013
5
PET-guided biopsy with needle navigation facilitates diagnosis of angiosarcoma in neurofibromatosis type 1. (23922330)
2013
6
Angiosarcoma of the humerus presenting with fluid-fluid levels on MRI: a unique imaging presentation. (23722293)
2013
7
Nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis. (24349811)
2013
8
Irradiation-induced angiosarcoma and anti-angiogenic therapy: A therapeutic hope? (24384475)
2013
9
Expression of angiopoietin-TIE system components in angiosarcoma. (23558570)
2013
10
Angiosarcoma of penis. (24351513)
2013
11
Percutaneous coronary intervention for control of post-operative bleeding in patients with cardiac angiosarcoma. (23787245)
2013
12
A Rare Case of Primary Pulmonary Epithelioid Angiosarcoma Detected by 18F-FDG PET/CT. (23657141)
2013
13
Angiosarcoma with extensive pulmonary metastases, presenting with spontaneous bilateral pneumothoraces. (24032383)
2013
14
Rupture of splenic angiosarcoma: a rare cause of spontaneous haemoperitoneum. (23709556)
2013
15
Angiosarcoma of the scalp successfully treated with a single therapy of sorafenib. (22710450)
2012
16
Epithelioid angiosarcoma arising in schwannoma: report of three Chinese cases with review of the literature. (22726071)
2012
17
Colonic angiosarcoma: a rare cause of bleeding. (22507877)
2012
18
MRI findings of large low-grade angiosarcoma of the breast with subsequent bone metastases: a case report. (22807947)
2012
19
Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy. (21997379)
2012
20
Cardiac angiosarcoma management and outcomes: 20-year single-institution experience. (22476752)
2012
21
Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient. (21752298)
2011
22
Angiosarcoma of the mandibular gingiva. (22135727)
2011
23
Cardiac angiosarcoma-associated membranoproliferative glomerulonephropathy. (21629818)
2011
24
Pathology quiz case 1. Angiosarcoma. (21339411)
2011
25
Primary breast angiosarcoma: avoiding a common trap. (22611503)
2011
26
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
27
Angiosarcoma mimicking a recurrent carotid artery aneurysm. (22023954)
2011
28
Synchronous bone marrow metastasis from primary splenic angiosarcoma. (21396272)
2010
29
Primary epithelioid angiosarcoma of the lung presenting as left-sided shoulder pain. (20838710)
2010
30
Gingival angiosarcoma mimicking necrotizing gingivitis. (20359867)
2010
31
Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma. (19836053)
2010
32
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
33
Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. (19696615)
2009
34
Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. (19008576)
2008
35
Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. (17720094)
2007
36
Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. (17667166)
2007
37
Primary ovarian angiosarcoma presenting as malignant cells in ascites: case report and review of the literature. (15830366)
2005
38
Primary left atrial angiosarcoma mimicking severe mitral valve stenosis. (15772176)
2005
39
A clinicopathological study of fifteen epithelioid angiosarcoma]. (12485481)
2002
40
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. (10964802)
2000
41
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
42
Mast cells in an angiosarcoma complicating xeroderma pigmentosum in a 13-year-old girl. (11044816)
2000
43
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. (9277092)
1996
44
Treatment of primary ovarian angiosarcoma with ifosfamide and doxorubicin. (8188092)
1994
45
Angiosarcoma of the heart causing cardiac rupture: a rare cause of hemopericardium. (8431074)
1993
46
Primary angiosarcoma of the heart causing cardiac rupture. (2741790)
1989
47
Two cases of liver angiosarcoma among polyvinyl chloride (PVC) extruders of an Italian factory producing PVC bags and other containers. (6539068)
1984
48
Canine angiosarcoma (lymphangiosarcoma). (7467082)
1981
49
Log normal distribution of the incubation period of liver angiosarcoma in vinyl chloride polymerization workers. (569691)
1979
50
Intravascular angiomatosis: development and distinction from angiosarcoma. (1237350)
1975

Variations for Angiosarcoma

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Expression for genes affiliated with Angiosarcoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiosarcoma

Search GEO for disease gene expression data for Angiosarcoma.

Pathways for genes affiliated with Angiosarcoma

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 62Tocris Bioscience, 61Thomson Reuters, 54QIAGEN, 58SinoBiological, 31KEGG, 5Cell Signaling Technology
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Pathways related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8KDR, PECAM1
2
Show member pathways
S1P2 pathway39
S1P4 pathway39
S1P5 pathway39
S1P1 pathway39
Sphingosine 1-phosphate (S1P) pathway39
9.8KDR, CDH5
3
Show member pathways
9.6FLT4, KDR
4
Show member pathways
9.6VEGFC, FLT4
59.3CDH5, ACTC1
69.3KDR, ACTC1
7
Show member pathways
9.2FLT4, KDR, VEGFC
8
Show member pathways
9.2FLT4, KDR, VEGFC
9
Show member pathways
9.2FLT4, KDR, VEGFC
10
Show member pathways
9.2FLT4, KDR, VEGFC
11
Show member pathways
9.2FLT4, KDR, VEGFC
12
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.2VEGFC, KDR, FLT4
13
Show member pathways
9.2VEGFC, KDR, FLT4
14
Show member pathways
8.9VEGFC, KDR, FLT4, CDH5
15
Show member pathways
VEGFR1 specific signals39
8.9CDH5, FLT4, KDR, VEGFC
168.8ANGPT2, FLT4, KDR, VEGFC
17
Show member pathways
8.8ANGPT2, FLT4, KDR, VEGFC
18
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
198.8VEGFC, KDR, FLT4, ANGPT2
20
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
21
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
22
Show member pathways
8.8VEGFC, KDR, FLT4, ANGPT2
238.2CDH5, PECAM1, VEGFC, KDR, FLT4, ANGPT2
24
Show member pathways
8.0VEGFC, KDR, FLT4, MUC1, ANGPT2, CDH5

Compounds for genes affiliated with Angiosarcoma

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Sources:
30IUPHAR, 46Novoseek, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 3BitterDB, 25HMDB
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Compounds related to Angiosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1vegfc3010.0FLT4, KDR
2vegfe3010.0FLT4, KDR
3azd 21714610.0FLT4, KDR
4zd6474469.9KDR, FLT4
5axitinib62 46 1211.9FLT4, KDR
6su5416469.9FLT4, KDR
7fucoidan469.8KDR, PECAM1
8pazopanib52 1210.8FLT4, KDR
9sunitinib46 52 1211.7KDR, FLT4
10progestin469.6KDR, MUC1, ANGPT2
11regorafenib52 1210.6FLT4, KDR
12lutein469.6ANGPT2, SERPINA3
13s 100469.5ACTC1, MUC1
14agar469.5MUC1, KDR, PECAM1
15reticulin469.4ACTC1, MUC1
162-methoxyethanol469.4KRT14, ACTC1
17sialic acid469.4PECAM1, SERPINA3, MUC1
18trastuzumab46 52 1211.3VEGFC, KDR, MUC1, ANGPT2
19folate469.3SERPINA3, KDR, MUC1
20hydrocortisone46 3 62 1212.2KDR, MUC1, KRT14, CDH5
21fibrinogen469.2CDH5, ANGPT2, SERPINA3, PECAM1
22ly294002469.2VEGFC, KDR, FLT4, ANGPT2
23formaldehyde46 2510.2PECAM1, MUC1, ACTC1
24heparin46 30 25 1212.1KDR, SERPINA3, VEGFC, PECAM1
25polysaccharide469.1SERPINA3, KDR, MUC1, CDH5
26mucicarmine469.1KRT14, ACTC1, MUC1
27estradiol46 25 1211.1CDH5, MUC1, SERPINA3, VEGFC
28thymidine46 2510.0PECAM1, VEGFC, KDR, MUC1, ANGPT2
29cyclosporin a46 30 6210.9ACTC1, ANGPT2, KDR, PECAM1
30hematoxylin468.8PECAM1, MUC1, ACTC1, KRT14
31cholesterol46 30 25 1211.8PECAM1, SERPINA3, MUC1, KRT14
32phosphatidylinositol468.7CDH5, ANGPT2, KDR, VEGFC
33nitric oxide46 25 1210.7PECAM1, VEGFC, KDR, MUC1, ANGPT2, CDH5
34arginine468.6SERPINA3, KDR, KRT14, CDH5
35creatinine468.5SERPINA3, MUC1, ANGPT2, ACTC1
36lipid468.3PECAM1, VEGFC, SERPINA3, MUC1, KRT14, CDH5
37cysteine468.2PECAM1, SERPINA3, KDR, MUC1, ANGPT2, KRT14
38ribonucleic acid468.2PECAM1, VEGFC, MUC1, ANGPT2, ACTC1, CDH5
39serine468.2PECAM1, SERPINA3, KDR, MUC1, ANGPT2, KRT14
40progesterone46 30 62 25 1212.1VEGFC, SERPINA3, MUC1, ACTC1, KRT14
41matrigel467.4PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
42vegf467.4PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
43dexamethasone46 52 30 1210.4VEGFC, SERPINA3, KDR, FLT4, MUC1, ANGPT2
44oxygen46 258.1PECAM1, VEGFC, SERPINA3, FLT4, MUC1, ANGPT2
45glucose467.1PECAM1, VEGFC, SERPINA3, MUC1, ANGPT2, ACTC1
46calcium46 52 25 1210.1PECAM1, VEGFC, SERPINA3, MUC1, ANGPT2, ACTC1
47tyrosine466.8PECAM1, VEGFC, KDR, FLT4, MUC1, ANGPT2
48estrogen466.5PECAM1, VEGFC, SERPINA3, KDR, FLT4, MUC1
49retinoic acid46 257.5PECAM1, VEGFC, SERPINA3, KDR, FLT4, MUC1
50paraffin466.2CDH5, PECAM1, VEGFC, KRT14, ACTC1, ANGPT2

GO Terms for genes affiliated with Angiosarcoma

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Sources:
17Gene Ontology
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Cellular components related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:0300549.5CDH5, KDR, PECAM1
2extracellular spaceGO:0056158.3ACTC1, ANGPT2, VEGFC, PECAM1
3extracellular regionGO:0055768.2ANGPT2, FLT4, KDR, SERPINA3, VEGFC
4extracellular vesicular exosomeGO:0700627.7PECAM1, SERPINA3, MUC1, ACTC1, KRT14

Biological processes related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:0019459.8FLT4, KDR
2cellular response to vascular endothelial growth factor stimulusGO:0359249.8KDR, FLT4
3positive regulation of endothelial cell migrationGO:0105959.7KDR, FLT4
4transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.6FLT4, KDR
5positive regulation of MAPK cascadeGO:0434109.5FLT4, KDR
6angiogenesisGO:0015259.5ANGPT2, KDR, VEGFC
7vascular endothelial growth factor receptor signaling pathwayGO:0480109.4FLT4, KDR, VEGFC
8positive regulation of endothelial cell proliferationGO:0019389.3KDR, FLT4
9positive regulation of cell proliferationGO:0082849.2FLT4, KDR, VEGFC

Molecular functions related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.6CDH5, FLT4
2vascular endothelial growth factor-activated receptor activityGO:0050219.6FLT4, KDR
3growth factor bindingGO:0198389.5KDR, FLT4
4transmembrane receptor protein tyrosine kinase activityGO:0047149.3FLT4, KDR
5protein bindingGO:0055156.7CDH5, PECAM1, VEGFC, SERPINA3, KDR, FLT4

Products for genes affiliated with Angiosarcoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angiosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet