MCID: ANG020
MIFTS: 61

Angiosarcoma malady

Cancer diseases category

Summaries for Angiosarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.

MalaCards: Angiosarcoma, also known as hemangiosarcoma, is related to sarcoma and lymphedema. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Tyrosine Kinases / Adaptors and VEGF Signaling Pathway. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include breast, endothelial and liver, and related mouse phenotypes are muscle and integument.

Wikipedia:63 Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may... more...

Aliases & Classifications for Angiosarcoma

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
angiosarcoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

angiosarcoma 8 44 48
hemangiosarcoma 8 60
hemangioendothelioma, malignant 8
malignant hemangioendothelioma 44
primary hemangiosarcoma 8


External Ids:

Disease Ontology8 DOID:0001816
NCIt39 C3088
MeSH34 D006394
SNOMED-CT via Orphanet57 403977003, 39000009

Related Diseases for Angiosarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Angiosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.5FLI1, CALB2, VIM, FLT4, ANGPT2, MUC1
2lymphedema30.4VEGFC, PROX1, FLT4, PDPN
3hemangioma30.4PECAM1, ACTC1, KDR, CD34, ANGPT2, PROX1
4breast cancer30.3VEGFC, PROX1, FLT4, FLI1, PDPN, TIE1
5kaposi's sarcoma30.2PDPN, FLI1, FLT4, VEGFC, CD34, KDR
6lymphangiosarcoma30.2PROX1
7squamous cell carcinoma30.2KRT14, KDR, FSCN1, CD34, MUC1, ANGPT2
8thrombocytopenia30.1FLI1, CD34, PECAM1
9lipoma30.0CD34
10fibrous histiocytoma29.9CD34
11hemangiopericytoma29.9VIM, MUC1, CD34, ACTC1
12epithelioid sarcoma29.9VIM, CALB2, MUC1, CDH5, CD34
13epithelioid hemangioendothelioma29.9FLT4, CD34
14adenoma29.9ACTC1, KRT14, FSCN1, MUC1, ANGPT2, FLT4
15malignant peripheral nerve sheath tumor29.9VIM, CALB2, CD34
16adenocarcinoma29.9VIM, TIE1, CALB2, PDPN, FLI1, PECAM1
17adenosarcoma29.9ACTC1
18liposarcoma29.8CD34, FLI1, CALB2, VIM
19fibrosarcoma29.8ACTC1, CD34, VIM
20colon cancer29.8CALB2, FLT4, FSCN1, KDR
21peritonitis29.7PECAM1
22cystadenoma29.7VEGFC
23hemangioendothelioma29.7CD34, FLT4, FLI1
24cystadenocarcinoma29.7MUC1
25leiomyoma29.7ACTC1, CD34, VIM
26gastrointestinal stromal tumor29.7ACTC1, KDR, CD34, VIM
27ischemia29.7TIE1, VEGFC, ANGPT2, KDR, PECAM1
28neurofibroma29.7VIM, MUC1, CD34, ACTC1
29peripheral primitive neuroectodermal tumor29.7FLI1
30papillary carcinoma29.7CALB2, VEGFC, MUC1, KRT14, ACTC1
31cervical cancer29.7KRT14, VEGFC, FLT4, PDPN
32malignant mesothelioma29.7VIM, CALB2, PDPN, FLT4, MUC1, KDR
33leiomyosarcoma29.7ACTC1, CD34, MUC1, CALB2, VIM
34malignant pleural mesothelioma29.7CALB2
35chondrosarcoma29.7SERPINA3, MUC1, VIM
36lymphangioleiomyomatosis29.7VEGFC
37ovarian cancer29.7CALB2, FLT4, VEGFC, MUC1, FSCN1, KDR
38brain cancer29.7ANGPT2, CDH5, KDR, PECAM1
39melanoma29.7PECAM1, SERPINA3, ACTC1, FLT4, VEGFC, ANGPT2
40cutaneous fibrous histiocytoma29.7CD34
41transitional cell carcinoma29.7KRT14, VEGFC, CALB2
42pneumonia29.7MUC1, VEGFC
43breast angiosarcoma10.7
44liver angiosarcoma10.6
45hepatitis10.4
46ovarian angiosarcoma10.4
47skin angiosarcoma10.4
48spleen angiosarcoma10.4
49thyroid angiosarcoma10.3
50hepatitis a10.3

Graphical network of the top 20 diseases related to Angiosarcoma:



Diseases related to angiosarcoma

Clinical Features for Angiosarcoma

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Drugs & Therapeutics for Angiosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angiosarcoma

Drug clinical trials:

Search ClinicalTrials for Angiosarcoma

Search NIH Clinical Center for Angiosarcoma

Search CenterWatch for Angiosarcoma

Genetic Tests for Angiosarcoma

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Anatomical Context for Angiosarcoma

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32MalaCards
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MalaCards organs/tissues related to Angiosarcoma:

32
Breast, Endothelial, Liver, Bone, Lung, Skin, Spleen, Thyroid, Heart, Ovary, Colon, Small intestine, Adrenal gland, Lymph node, Kidney, Prostate, Bone marrow, Uterus, Pancreas, Brain, Tongue, Cervix, Tonsil, T cells

Animal Models for Angiosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiosarcoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.6TIE1, FLI1, KDR, SLC6A6, ACTC1
2MP:001077110.6TIE1, ANGPT2, CD34, KDR, KRT14
3MP:000537610.6PDPN, PROX1, CD34, SLC6A6, KRT14, ACTC1
4MP:000538510.5PECAM1, VIM, TIE1, PDPN, FLI1, FLT4
5MP:000538110.5TIE1, PDPN, FLT4, PROX1, ANGPT2, MUC1
6MP:000539110.5VIM, PROX1, ANGPT2, MUC1, SLC6A6, KRT14
7MP:000538710.4PROX1, FLT4, FLI1, PDPN, TIE1, VIM
8MP:000537010.4FLT4, PROX1, MUC1, KDR, PECAM1, FLI1
9MP:000538410.3VIM, TIE1, FLI1, PROX1, CDH5, CD34
10MP:000538810.3TIE1, PDPN, PROX1, KDR, KRT14, PECAM1
11MP:001076810.3FLT4, FLI1, PDPN, TIE1, VIM, PROX1
12MP:000537810.0VIM, TIE1, PDPN, FLI1, FLT4, PROX1

Publications for Angiosarcoma

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50PubMed
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Articles related to Angiosarcoma:

(show top 50)    (show all 684)
idTitleAuthorsYear
1
Postradiation cutaneous angiosarcoma of the breast: a diagnosis to keep in mind. (24237660)
2014
2
Expression of angiopoietin-TIE system components in angiosarcoma. (23558570)
2013
3
A Rare Case of Primary Pulmonary Epithelioid Angiosarcoma Detected by 18F-FDG PET/CT. (23657141)
2013
4
Angiosarcoma with extensive pulmonary metastases, presenting with spontaneous bilateral pneumothoraces. (24032383)
2013
5
Radiology-pathology conference: cutaneous angiosarcoma of the leg. (23601777)
2013
6
MYC amplification and overexpression in primary cutaneous angiosarcoma: a fluorescence in-situ hybridization and immunohistochemical study. (24091875)
2013
7
Angiosarcoma associated with a Kasabach-Merritt syndrome: report of two cases treated with paclitaxel. (23980686)
2013
8
Colonic angiosarcoma: A case report and review of literature. (23279809)
2013
9
Application of helical tomotherapy for the treatment of a right atrium angiosarcoma: a case report. (24362876)
2013
10
Ultrasound challenge: secondary breast angiosarcoma mimicking lipoma. (23701498)
2013
11
ROCK1 &amp; 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression. (22934846)
2013
12
Cutaneous angiosarcoma clinically presenting as progressive solid facial edema in a 43-year-old male. (24314784)
2013
13
Primary angiosarcoma of the esophagus. (23272886)
2013
14
Angiosarcoma originating from an ovarian mature teratoma, a rare disease with complex treatment modalities. (24371690)
2013
15
Single institutional experience of the treatment of angiosarcoma of the face and scalp. (24014066)
2013
16
Angiosarcoma of the scalp successfully treated with a single therapy of sorafenib. (22710450)
2012
17
Cardiac angiosarcoma on the right atrium: two cases. (22500283)
2012
18
Adrenal epithelioid angiosarcoma metastatic to the epicardium: diagnosis by 18F-FDG PET/CT. (22889791)
2012
19
Partial response of angiosarcoma of the scalp to sorafenib: association with decreased expression of vascular endothelial growth factors and their receptors. (22369131)
2012
20
Epithelioid angiosarcoma of the kidney: a diagnostic dilemma in fine-needle aspiration cytology. (21698784)
2012
21
Mixed angiosarcoma, clear cell adenocarcinoma and mature teratoma elements in an ovarian tumor: a case report and literature review. (22827762)
2012
22
Angiosarcoma presenting as subdural hematoma. (22406811)
2012
23
Angiosarcoma of the mandibular gingiva. (22135727)
2011
24
Primary jejunal angiosarcoma: an extremely rare tumor diagnosed by means of anterograde spiral enteroscopy. (21590614)
2011
25
Atrial angiosarcoma imaged by F-18 FDG PET/CT. (21592927)
2011
26
Diagnostic dilemma; report of a bizarre case of advanced scalp and face angiosarcoma and literature review. (23754910)
2011
27
Cutaneous angiosarcoma is a rare aggressive malignant vascular tumour of the skin. (21108661)
2011
28
A fatal case of cutaneous multicentric epithelioid angiosarcoma. (21920236)
2011
29
Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity. (20196675)
2010
30
Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas. (20459536)
2010
31
Lifesaving kissing stent for pulmonary trunk stenosis due to primary angiosarcoma. (21035708)
2010
32
Angiosarcoma of the eyelid: a clinicopathologic comparison between isolated unilateral tumors and tumors demonstrating extrapalpebral involvement. (20559124)
2010
33
Cardiac angiosarcoma and recurrent pericardial effusion. (20622718)
2010
34
Radiology quiz case 1. Metastatic cutaneous angiosarcoma of the scalp with perineural spread. (20403861)
2010
35
Epithelioid angiosarcoma of the scapula. (20952750)
2010
36
Primary epithelioid angiosarcoma of bone: a case report with immunohistochemical study. (21045426)
2010
37
Cardiac angiosarcoma diagnosed by transvenous endomyocardial biopsy with the aid of transesophageal echocardiography and intra-procedural consultation. (20966612)
2010
38
Angiosarcoma in an area of lipodermatosclerosis. (18634723)
2008
39
Spontaneous regression of pulmonary metastases from breast angiosarcoma. (19081840)
2008
40
Epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma: a case report and literature review. (17574948)
2007
41
Bilateral massive bloody pleurisy complicated by angiosarcoma. (17268128)
2007
42
Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases. (11145248)
2001
43
Cytologic evaluation of primary malignant vascular tumors of the liver. One case each of angiosarcoma and epithelioid hemangioendothelioma. (9305386)
1997
44
Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma. (8163270)
1994
45
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. (1793483)
1991
46
Epithelioid sarcoma mimicking angiosarcoma: the value of immunohistochemistry in the differential diagnosis. (1900974)
1991
47
Primary angiosarcoma of the heart causing cardiac rupture. (2741790)
1989
48
Canine angiosarcoma (lymphangiosarcoma). (7467082)
1981
49
Intravascular papillary endothelial hyperplasia. A benign lesion mimicking angiosarcoma. (565619)
1978
50
Angiosarcoma with pulmonary siderosis and persistent reticulocytosis. Steroid responsiveness suggests an immune basis. (568458)
1978

Genetic Variations for Angiosarcoma

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Expression for genes affiliated with Angiosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiosarcoma

Search GEO for disease gene expression data for Angiosarcoma.

Pathways for genes affiliated with Angiosarcoma

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4Cell Signaling Technology, 49PharmGKB, 55SinoBiological, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Angiosarcoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9CALB2
2dexamethasone44 49 28 1113.9KDR, ANGPT2, VEGFC
3reticulin4410.8VIM, MUC1, CD34, ACTC1
4s 1004410.8VIM, MUC1, ACTC1
5ribonucleic acid4410.8VEGFC, ANGPT2, MUC1, CDH5, ACTC1, PECAM1
6vegfe2810.8FLT4, KDR
7sialic acid4410.8PECAM1
8trastuzumab44 49 1112.8VEGFC, ANGPT2, MUC1, KDR
9mucicarmine4410.8VIM, CALB2, MUC1, KRT14, ACTC1
102-methoxyethanol4410.8ACTC1, KRT14, VIM
11vegfc2810.8FLT4, KDR
12hydrocortisone44 2 59 1113.8VIM, MUC1, CDH5, KDR, KRT14
13b 7234410.8ACTC1, MUC1, PDPN, CALB2, VIM
14matrigel4410.8FLT4, VEGFC, ANGPT2, MUC1, CDH5, KDR
15glucose4410.8VEGFC, ANGPT2, MUC1, CDH5, KRT14, ACTC1
16azd 21714410.8FLT4, KDR
17progestin4410.8KDR, MUC1, ANGPT2, VIM
18serine4410.8PECAM1, SERPINA3, KRT14, SLC6A6, FSCN1
19oxygen44 2411.8FLT4, VEGFC, ANGPT2, MUC1, CDH5, SERPINA3
20thymidine44 2411.8CALB2, VEGFC, ANGPT2, MUC1, CD34, KDR
21agar4410.8VIM, MUC1, CD34, KDR, PECAM1
22hematoxylin4410.8PECAM1, ACTC1, KRT14, CD34, MUC1, PDPN
23nitric oxide44 11 2412.7TIE1, CALB2, VEGFC, ANGPT2, MUC1, CDH5
24polysaccharide4410.7SERPINA3, KDR, CDH5, MUC1, PDPN
25progesterone44 59 28 11 2414.7VIM, CALB2, VEGFC, MUC1, CD34, KRT14
26formaldehyde44 2411.7PECAM1, ACTC1, MUC1, VIM
27orcein4410.7ACTC1, VIM
28folate4410.7SERPINA3, KDR, MUC1, VIM
29estradiol44 11 2412.7VIM, VEGFC, MUC1, CDH5, SERPINA3
30cysteine4410.7VIM, ANGPT2, MUC1, KDR, SLC6A6, KRT14
31retinoic acid44 2411.7PECAM1, VIM, FLT4, VEGFC, ANGPT2, MUC1
32creatinine4410.7ANGPT2, ACTC1, SERPINA3
33vegf4410.7VIM, TIE1, PDPN, FLT4, PECAM1, ACTC1
34eosin4410.7MUC1, VIM
35heparin44 28 11 2413.7PECAM1, SERPINA3
36zd64744410.7FLT4, KDR
37calcium44 49 11 2413.7CALB2, VEGFC, ANGPT2, MUC1, CDH5, FSCN1
38lipid4410.7VIM, VEGFC, MUC1, CDH5, KRT14, SERPINA3
39tyrosine4410.6ANGPT2, VEGFC, FLT4, PDPN, CALB2, TIE1
40paraffin4410.6PECAM1, VIM, CALB2, PDPN, FLT4, VEGFC
41axitinib44 59 1112.6KDR, FLT4
4212-o-tetradecanoylphorbol 13-acetate4410.6FSCN1, CD34, MUC1, VIM
43butyrate4410.6CALB2
44silver4410.5CALB2, CD34, SERPINA3
45tamoxifen44 49 28 1113.5KRT14, KDR, MUC1, VIM
46rapamycin4410.4PECAM1, KDR, FLT4, VIM
47paclitaxel44 49 1112.4CALB2, FLT4, KDR
48fibrinogen4410.3PECAM1, SERPINA3, CDH5, ANGPT2
49testosterone44 59 11 2413.1VIM, CALB2, VEGFC, MUC1, ACTC1

GO Terms for genes affiliated with Angiosarcoma

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16Gene Ontology
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Cellular components related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.3SLC6A6, KDR, CD34, MUC1, FLT4, PDPN

Biological processes related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor signaling pathwayGO:04801010.7FLT4, VEGFC, KDR
2lymphangiogenesisGO:00194610.7PROX1, FLT4, PDPN
3positive regulation of endothelial cell migrationGO:01059510.7KDR, PROX1, FLT4
4glomerular endothelium developmentGO:07201110.7CD34, PECAM1
5endothelium developmentGO:00315810.6CD34, KDR
6skeletal muscle thin filament assemblyGO:03024010.6ACTC1, PROX1
7positive regulation of endothelial cell proliferationGO:00193810.6KDR, PROX1, FLT4
8angiogenesisGO:00152510.5TIE1, VEGFC, ANGPT2, KDR
9lymph vessel developmentGO:00194510.5KDR, FLT4
10positive regulation of vasculogenesisGO:200121410.4KDR, CD34
11leukocyte migrationGO:05090010.4PECAM1, CD34, ANGPT2
12signal transductionGO:00716510.3TIE1, PDPN, VEGFC, ANGPT2, CD34, PECAM1
13positive regulation of angiogenesisGO:04576610.1KDR, CD34, ANGPT2

Molecular functions related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:00502110.4KDR, FLT4
2transmembrane receptor protein tyrosine kinase activityGO:00471410.3KDR, FLT4, TIE1
3protein bindingGO:0055159.9VIM, TIE1, FLT4, PROX1, VEGFC, ANGPT2

Products for genes affiliated with Angiosarcoma

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  • Antibodies
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Sources for Angiosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet