Angiosarcoma malady

Disease Ontology: A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.⁶

MalaCards: Angiosarcoma, also known as hemangiosarcoma, is related to kaposiform hemangioendothelioma and angiosarcoma of the scalp. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Sorafenib Pharmacodynamics and Breast Cancer Regulation by Stathmin1. The compounds cyclophosphamide and threonine have been mentioned in the context of this disorder. Affiliated tissues include spleen, kidney and liver, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may...⁴⁴ more...

Aliases & Descriptions:

angiosarcoma 6 8 32 hemangiosarcoma 6 43 hemangioendothelioma, malignant (morphologic abnormality) 6

primary hemangiosarcoma 6 hemangioendothelioma 43 primary angiosarcoma 43

Diseases related to angiosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 820)

id	Related Disease	Score	Top Affiliating Genes
1	kaposiform hemangioendothelioma	33.6	CD34, FLI1, FLT4, IFNA2, PROX1
2	angiosarcoma of the scalp	32.4	VEGFC, KDR, CDH5, PECAM1
3	lymphangiosarcoma	29.6	FLT4, F8, PROX1
4	kaposi's sarcoma	28.8	VEGFA, VEGFC, KDR, CD34, FLI1, FLT4
5	tufted angioma	28.5	FLT4, ENG, IFNA2, TEK, PROX1
6	adenoid squamous cell carcinoma	28.5	VIM, MUC1, CD34
7	malignant peripheral nerve sheath tumor	27.3	KIT, VIM, MUC1, S100B, CDKN2A, CD34
8	hepatitis	27.2	CDH5, IFNA1, IFNA2, KRT8, KRT18, GGT1
9	lymphedema	26.6	VEGFA, VEGFB, VEGFC, MYC, KDR, FLT4
10	hemangioendothelioma	26.5	VWF, VEGFA, KDR, S100B, CD34, FLT1
11	hemangioma of lung	26.2	MUC1, CDKN2A, CDKN3, ERBB2, TP53, PTEN
12	lymphangioleiomyomatosis	26.2	VIM, VEGFA, VEGFC, S100B, FIGF, ESR1
13	hemangiopericytoma	26.0	VIM, VEGFA, KDR, MUC1, S100B, CD34
14	sclerosing hemangioma	25.8	MYC, MUC1, CDKN2A, CDKN3, ERBB2, TP53
15	bilateral breast cancer	25.3	BRCA1, CDKN3, ESR1, ERBB2, TP53, PTEN
16	breast cancer	25.0	BRCA1, VEGFA, KDR, FLT1, MDM2, CCND1
17	thrombocytopenia	24.7	KITLG, VWF, CD34, FLI1, IL2, ANGPT1
18	mediastinitis	24.7	PIK3CG, KIT, VIM, VEGFC, MYC, CD68
19	vasculitis	24.5	VWF, SERPINA3, VEGFA, VEGFC, KDR, CD68
20	liposarcoma	24.3	KIT, VIM, VEGFA, KDR, MUC1, CDKN2A
21	chondrosarcoma	23.4	PIK3CG, SERPINA3, VIM, VEGFA, MYOG, MYOD1
22	hemangioma	22.4	KITLG, VWF, VEGFA, MYC, KDR, MUC1
23	malignant pleural mesothelioma	22.3	KIT, VIM, VEGFA, KDR, MUC1, CDKN2A
24	fibrosarcoma	21.9	PIK3CG, KIT, KITLG, VIM, VEGFA, MYOD1
25	squamous cell carcinoma	21.1	SERPINA3, VIM, VEGFA, VEGFB, VEGFC, MYC
26	rhabdomyosarcoma	20.6	KITLG, VIM, VEGFA, MYC, MYOG, MYOD1
27	adenoiditis	20.5	KIT, SERPINA3, VIM, VEGFA, KDR, MUC1
28	osteosarcoma	16.3	PIK3CG, KIT, VWF, VIM, BRCA1, VEGFA
29	sarcoma	15.5	PIK3CG, KIT, KITLG, VWF, SERPINA3, VIM
30	carcinoma	14.0	PIK3CG, KIT, KITLG, VWF, SERPINA3, VIM
31	lymphedema, congenital	13.9	VEGFC, FLT4, FIGF, PDPN
32	lipodermatosclerosis	13.9	FLT1, ANGPT2, ANGPT1
33	epithelioid leiomyosarcoma	13.9	VIM, ACTC1, DES
34	glomangiomyoma	13.9	VIM, ACTC1, DES
35	infantile myofibromatosis	13.9	VIM, ACTC1, DES
36	pulmonary vein stenosis	13.9	PDGFRA, ACTC1, DES, PECAM1
37	myofibroma	13.9	VIM, ACTC1, DES
38	arteriovenous malformation	13.9	KDR, FLT1, ENG, TEK
39	epithelioid sarcoma	13.9	VIM, MUC1, CDH5, CD34, CALB2, KRT8
40	adenoameloblastoma	13.9	SERPINA3, CALB2, PDPN, KRT8, KRT18, KRT14
41	gallbladder sarcoma	13.9	MYOG, MYOD1, KRT18
42	mesenchymal chondrosarcoma	13.9	VIM, MUC1, DES
43	glomangioma	13.9	TEK, ACTC1, DES
44	ossifying fibroma	13.8	VIM, CD34, CALB2, ACTC1, DES
45	pseudosarcomatous fibromatosis	13.8	VIM, MYOG, ACTC1, DES
46	placental insufficiency	13.8	VWF, FLT1, ANGPT2, CALB2, TEK
47	cutaneous fibrous histiocytoma	13.8	VIM, CD34, CD68, DES
48	syringocystadenoma papilliferum	13.8	VIM, MUC1, S100B, ACTC1
49	malignant giant cell tumor of soft parts	13.8	S100B, ACTC1, DES
50	follicular dendritic cell tumor	13.8	S100B, FSCN1, CD68, PDPN, ACTC1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to angiosarcoma:

²²

MGI Mouse Phenotypes related to angiosarcoma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	TIE1, TP63, BRCA1, MYOG, MYOD1
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	GGT1, PROX1, TKT, KRAS, TP63, IL2
3	craniofacial phenotype	MP:0005382	9.3	CSF1, PDGFRB, PDGFRA, TP73, CDH5, KITLG
4	other phenotype	MP:0005395	9.1	STAT3, PDGFRA, TP73, IL2, MME, CDKN2A
5	hematopoietic system phenotype	MP:0005397	8.7	CD68, FLI1, MDM2, ENG, CCND1, ETS1
6	liver/biliary system phenotype	MP:0005370	8.6	KIT, VEGFA, ATF2, FLI1, IL2, TP53
7	embryogenesis phenotype	MP:0005380	8.6	KIT, VIM, BRCA1, MYC, MYOG, ATF2
8	behavior/neurological phenotype	MP:0005386	8.5	CALB2, TP73, PTEN, PDGFRA, PDPN, ACPP
9	renal/urinary system phenotype	MP:0005367	8.3	PDGFRB, KRAS, HIF1A, TKT, TIE1, PDGFRA
10	normal phenotype	MP:0002873	8.3	FIGF, ENG, CALB2, TP63, PDGFRA, KRAS
11	limbs/digits/tail phenotype	MP:0005371	7.9	GGT1, CSF1, KRAS, PDGFRA, TP63, ERBB2
12	pigmentation phenotype	MP:0001186	7.7	PTEN, PDGFRA, KRAS, KRT14, GGT1, TP53
13	adipose tissue phenotype	MP:0005375	7.4	TP53, PTEN, PDGFRB, TKT, STAT3, PROX1
14	digestive/alimentary phenotype	MP:0005381	6.6	ANGPT2, ESR1, ERBB2, TP63, PTEN, PLG
15	immune system phenotype	MP:0005387	6.6	TP53, TP63, PLG, PDGFRA, PDGFRB, PDPN
16	integument phenotype	MP:0010771	6.2	PIK3CG, KIT, KITLG, BRCA1, PDPN, KRAS
17	mortality/aging	MP:0010768	5.6	KITLG, ANGPT2, ANGPT1, CCND1, F8, ETS1
18	tumorigenesis	MP:0002006	5.3	MDM2, CCND1, ESR1, ERBB2, TP53, TP63
19	skeleton phenotype	MP:0005390	5.0	ESR1, ERBB2, TP53, TP63, TP73, PTEN
20	cellular phenotype	MP:0005384	3.7	PDGFRB, KRAS, KRT14, ACP1, ACTC1, HBA2
21	muscle phenotype	MP:0005369	INF	MYOD1, PDGFRB, PDPN, KRAS, ACTC1, HBA2
22	nervous system phenotype	MP:0003631	INF	TEK, PTEN, PLG, PDGFRA, KRAS, HIF1A
23	growth/size phenotype	MP:0005378	INF	GGT1, , PIK3CG, KIT, KITLG, BRCA1
24	vision/eye phenotype	MP:0005391	INF	PLG, PDGFRB, KRAS, KRT14, HIF1A, TKT
25	reproductive system phenotype	MP:0005389	INF	BRCA1, VEGFA, MYOD1, , CSF1, STAT3
26	homeostasis/metabolism phenotype	MP:0005376	INF	FIGF, PDGFRA, PDGFRB, PDPN, KRAS, KRT14
27	cardiovascular system phenotype	MP:0005385	INF	FLI1, FLT4, FIGF, IL2, MDM2, ENG

Articles related to angiosarcoma:

(show top 50)    (show all 72)

id	Title	Authors	Year	Affiliating Genes
1	Consistent MYC and FLT4 gene amplification in radiati on-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. (20949568)	Guo T.... Antonescu C.R.	2011	FLT4, MYC
2	Contrasting prognostic implications of platelet-deriv ed growth factor receptor-I^ and vascular endothelial growth factor receptor-2 i n patients with angiosarcoma. (21409488)	Yonemori K.... Hasegawa T.	2011	KDR, PDGFRB
3	Autocrine and paracrine roles of VEGF/VEGFR-2 and VEG F-C/VEGFR-3 signaling in angiosarcomas of the scalp and face. (19913279)	Tokuyama W.... Okayasu I.	2010	KDR, VEGFC
4	MYC high level gene amplification is a distinctive fe ature of angiosarcomas after irradiation or chronic lymphedema. (20008140)	Manner J.... StrAPbel P.	2010	MYC
5	Inhibiting the VEGF-VEGFR pathway in angiosarcoma, ep ithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)	Park M.S.... Araujo D.M.	2010	KDR, VEGFA
6	Epithelioid angiosarcoma: a neoplasm with potential d iagnostic challenges. (19813270)	Lin C.F.... Lin X.	2010	MME, ACPP, ALPPL2
7	Cutaneous angiosarcoma after breast conserving treatm ent for bilateral breast cancers in a BRCA-1 gene mutation carrier--a case repo rt and review of the literature. (19736894)	Williams S.B.... Reed M.	2009	BRCA1
8	Dramatic and durable efficacy of imatinib in an advan ced angiosarcoma without detectable KIT and PDGFRA mutations. (19182535)	Kiesel H.... Veelken H.	2009	PDGFRA, KIT, TKT
9	Angiosarcoma of the kidney with minute clear cell car cinomas: a case report. (19147300)	Fukunaga M.	2009	PECAM1
10	The VEGF-system in primary pulmonary angiosarcomas an d haemangioendotheliomas: new potential therapeutic targets? (19100646)	Stacher E.... Popper H.H.	2009	FLT4, KDR, VEGFC
11	Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. (18671846)	Driemel O.... Kosmehl H.	2008	FLI1
12	Pseudolymphomatous cutaneous angiosarcoma: a rare variant of cutaneous angiosarcoma readily mistaken for cutaneous lymphoma. (17667166)	Requena L.... Cerroni L.	2007	PROX1
13	Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. (17720094)	Lin N.... Urabe K.	2007	CCND1, STAT3
14	Mutation of the PTEN gene in a human hepatic angiosarcoma. (17954274)	Tate G.... Mitsuya T.	2007	PTEN, PIK3CG, ACP1
15	Intracranial angiosarcoma arising from a schwannoma. (16995966)	Ito T.... Kitamura K.	2007	CD34
16	A case of cardiac angiosarcoma successfully treated with docetaxel (18030022)	Ishibashi N.... Murakami K.	2007	IL2
17	Bilateral massive bloody pleurisy complicated by angiosarcoma. (17268128)	Moriya Y.... Takahashi H.	2007	VIM
18	Clinical and immunohistochemical findings of intra- and extraoral angiosarcomas (16788797)	Driemel O.... Kosmehl H.	2006	FLII
19	Angiosarcoma involving the gastrointestinal tract: a series of primary and metastatic cases. (15104292)	Allison K.H.... Rubin B.P.	2004	S100B, KRT20
20	Establishment and characterization of an angiosarcoma-derived cell line, AS-M. (14741847)	Krump-Konvalinkova V.... Kirkpatrick C.J.	2003	VWF, ENG, TIE1
21	Angiosarcoma of the larynx. Case report and review of the literature. (14677313)	Sorrentino R.... Castelli M.L.	2003	VIM
22	A clinicopathological study of fifteen epithelioid angiosarcoma (12485481)	Liu M.... Li X.	2002	F8
23	Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma. (12218574)	Folpe A.L.... Weiss S.W.	2002	DES, MYOD1, MYOG
24	Angiosarcoma of the scalp: absence of vascular endothelial cadherin in primary and metastatic lesions. (11251578)	Tanioka M.... Miyachi Y.	2001	CDH5
25	Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases. (11145248)	McMenamin M.E.... Fletcher C.D.	2001	S100B
26	Metastatic angiosarcoma of the spleen. A case report and treatment approach. (11989602)	Rupolo M.... Frustaci S.	2001	CSF3
27	Epithelioid angiosarcoma of the pleura: a case report. (11748365)	Roh M.S.... Hong S.H.	2001	VIM
28	Chromosomal abnormalities and p53 gene mutation in a cardiac angiosarcoma. (11277410)	Zu Y.... Waisman J.	2001	TP53
29	Angiosarcoma of vagina successfully treated with inte rleukin-2 therapy and chemotherapy: a case report. (11721736)	Morimura Y.... Sato A.	2001	IL2
30	Immunohistological distribution of stem cell factor and kit receptor in angiosarcoma. (11243641)	Yamamoto T.... Nishioka K.	2000	KITLG
31	Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)	Folpe A.L.... Weiss S.W.	2000	FLT4, VWF, PECAM1
32	KIT expression in angiosarcomas and fetal endothelial cells: lack of mutations of exon 11 and exon 17 of C-kit. (10824925)	Miettinen M.... Lasota J.	2000	KIT
33	Overexpression of Ets-1 transcription factor in angiosarcoma of the skin. (10707367)	Naito S.... Sekine I.	2000	ETS1
34	Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. (10854238)	Brown L.F.... Yancopoulos G.D.	2000	TEK, ANGPT1, ANGPT2
35	Podoplanin--a specific marker for lymphatic endothelium expressed in angiosarcoma (10714221)	Breiteneder-Geleff S.... Kerjaschki D.	1999	PDPN
36	MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas. (9811333)	Zietz C.... LAPhrs U.	1998	MDM2, TP53, VEGFA
37	Pseudomesotheliomatous angiosarcoma: a pleuropulmonary lesion simulating malignant pleural mesothelioma. (9181362)	Falconieri G.... Zanella M.	1997	VIM
38	Multicentric epithelioid angiosarcoma of the bone. Pitfalls in clinical and morphological diagnosis. (9075571)	Balicki D.... HA1ttner I.	1996	VIM
39	Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma. (8644848)	Brown L.F.... Harrist T.J.	1996	FLT1, KDR, VEGFA
40	Wilson-Jones type angiosarcoma with marked response to intrapleural administration of interleukin-2 (8822000)	Yamada Y.... Kuriyama T.	1995	IL2
41	Expression of vascular endothelial growth factor and its receptor mRNA in angiosarcoma. (8558848)	Hashimoto M.... Aozasa K.	1995	FLT1
42	A case of angiosarcoma with renal failure caused by recombinant interleukin-2 (rIL-2) and non-steroid anti-inflammatory drug (NSAID) (7776536)	Shimizu I.... Maeda T.	1995	MUC1
43	Therapeutic possibilities of recombinant interferon alfa-2b (Intron A) in non-AIDS Kaposi sarcomas and angiosarcomas (7590408)	JeliA8 S.... MarinkoviA8 M.	1994	IFNA2
44	Primary angiosarcoma of the alveolar mucosa in a haem odialysis patient: case report and discussion. (7823305)	Margiotta V.... Giuliana G.	1994	DES
45	Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases. (8372948)	Falk S.... Meis J.M.	1993	CD68
46	A case of angiosarcoma presenting as ill-defined opacities on chest roentgenogram and hemothorax (8351442)	Kumagai M.... Kawana A.	1993	CRP
47	Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. (1599022)	Nappi O.... Swanson P.E.	1992	VIM, MUC1
48	Soft tissue angiosarcoma in a child. Immunohistochemical and ultrastructural features (1580939)	Sastre-Garau X.... Laurent M.	1992	VIM
49	Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. (1793483)	Marion M.J.... Trepo C.	1991	KRAS
50	Primary retroperitoneal angiosarcoma with eosinophilic globules. A combined light-microscopic, immunohistochemical, and ultrastructural study. (1693269)	Vuletin J.C.... Ghali V.	1990	SERPINA3

Genes related to angiosarcoma according to GeneCards:

(show top 50)    (show all 78)

id	Symbol	Description	Score	GeneCards Section Context
1	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
2	CDH5	cadherin 5, type 2 (vascular endothelium)	11.0	Publications
3	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0	Publications
4	VEGFC	vascular endothelial growth factor C	11.0	Publications
5	TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	11.0	Publications
6	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0
7	ANGPT2	angiopoietin 2	11.0	Publications
8	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
9	FLI1	Friend leukemia virus integration 1	11.0	Publications
10	CD34	CD34 molecule	11.0	Publications
11	FLT4	fms-related tyrosine kinase 4	11.0	Publications
12	KRT14	keratin 14	11.0
13	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
14	PDPN	podoplanin	11.0	Publications
15	TEK	TEK tyrosine kinase, endothelial	11.0	Publications
16	KRT8	keratin 8	11.0
17	KRT18	keratin 18	11.0
18	CHAT	choline O-acetyltransferase	11.0
19	CALB2	calbindin 2	11.0
20	VIM	vimentin	11.0	Publications
21	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
22	MUC1	mucin 1, cell surface associated	11.0	Publications
23	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
24	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0	Publications
25	ANGPT1	angiopoietin 1	11.0	Publications
26	VWF	von Willebrand factor	11.0	Publications
27	FLII	flightless I homolog (Drosophila)	11.0	Publications
28	PROX1	prospero homeobox 1	11.0	Publications
29	HARS	histidyl-tRNA synthetase	11.0
30	CD68	CD68 molecule	11.0	Publications
31	VEGFB	vascular endothelial growth factor B	11.0	Publications
32	ALPPL2	alkaline phosphatase, placental-like 2	11.0	Publications
33	MYOG	myogenin (myogenic factor 4)	11.0	Publications
34	ANGPT4	angiopoietin 4	11.0	Publications
35	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	11.0	Publications
36	MYOD1	myogenic differentiation 1	11.0	Publications
37	KRT20	keratin 20	11.0	Publications
38	ATF2	activating transcription factor 2	11.0	Publications
39	ANXA2	annexin A2	11.0	Publications
40	ACPP	acid phosphatase, prostate	11.0	Publications
41	DES	desmin	11.0	Publications
42	ENG	endoglin	11.0	Publications
43	S100B	S100 calcium binding protein B	11.0	Publications
44	ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	11.0	Publications
45	ACP1	acid phosphatase 1, soluble	11.0	Publications
46	THOC2	THO complex 2	11.0
47	PLG	plasminogen	11.0	Publications
48	HBA2	hemoglobin, alpha 2	11.0
49	HBA1	hemoglobin, alpha 1	11.0
50	TP73	tumor protein p73	11.0	Publications

Pathways related to angiosarcoma according to GeneDecks:

(show top 50)    (show all 132)

id	Pathway	Score	Top Affiliating Genes
1	Sorafenib Pharmacodynamics34	10.4	KDR, KRAS, PDGFRB, FLT4, FLT1
2	Breast Cancer Regulation by Stathmin136	10.3	TEK, FIGF, ERBB2, VEGFB
3	Pathway_PA16595942534	10.1	KRAS, FLT4, FLT1, KDR, KIT
4	Pathway_PA16598005034	10.1	PDGFRB, PDGFRA, ETS1, FLT4, FLT1, KDR
5	Renal cell carcinoma20	10.0	ETS1, HIF1A, FIGF
6	Ras Pathway36	9.9	ATF2, KIT, VEGFB, TEK, FIGF, FLT4
7	Angiogenesis3	9.8	ETS1, TEK, PDGFRA, PDGFRB, HIF1A, PECAM1
8	14-3-3 Induced Intracellular Signaling36	9.7	PDGFRA, TEK, FIGF, TP73, VEGFC, FLT4
9	Tyrosine Kinases / Adaptors3	9.6	KITLG, KIT, VEGFB, VEGFC, KDR, PDGFRA
10	P2Y Receptor Signaling36	9.5	TEK, FIGF, FLT4, FLT1, KDR, MYC
11	TGF-Beta Pathway36	9.5	IL2, ANGPT1, FLT1, VEGFC, KITLG, VEGFB
12	DHA Signaling36	9.4	PDGFRA, IL2, FIGF, FLT4, FLT1, KDR
13	ERK5 Signaling36	9.3	KDR, KITLG, KIT, FIGF, VEGFB, IL2
14	Nanog in Mammalian ESC Pluripotency36	9.3	VEGFC, TEK, KDR, FLT1, FLT4, FIGF
15	Renin-Angiotensin Pathway36	9.3	FLT1, STAT3, ATF2, FLT4, FIGF, VEGFB
16	Paxillin Interactions36	9.3	VEGFB, KIT, KITLG, VEGFC, KDR, FLT1
17	PPAR Pathway36	9.3	KIT, IL2, PDGFRB, PDGFRA, FIGF, FLT4
18	ILK Signaling36	9.2	HIF1A, KRT18, PDGFRB, PDGFRA, TEK, ERBB2
19	NFAT in Immune Response36	9.2	ATF2, VEGFC, VEGFB, KIT, KITLG, ERBB2
20	GSK3 Signaling36	9.2	ERBB2, VEGFC, KDR, CDH5, PDGFRB, FLT1
21	eIF2 Pathway36	9.2	PDGFRB, FIGF, FLT4, VEGFC, KITLG, KIT
22	Focal adhesion20	9.1	PDGFRA, VEGFB, PIK3CG, PDGFRB, PTEN, ERBB2
23	GPCR Pathway36	9.0	FLT1, PDGFRB, FLT4, FIGF, IL2, ERBB2
24	PAK Pathway36	9.0	VEGFC, FIGF, IL2, ANGPT2, ANGPT1, ANGPT4
25	eNOS Signaling36	9.0	KITLG, FLT4, FIGF, IL2, KIT, ESR1
26	Antioxidant Action of Vitamin-C36	8.9	KIT, PDGFRA, CSF1, KDR, KITLG, VEGFB
27	Akt Signaling36	8.9	CSF1, PDGFRB, PDGFRA, TEK, CCND1, ANGPT4
28	Apoptotic Pathways in Synovial Fibroblasts36	8.9	VEGFB, KIT, KITLG, VEGFC, KDR, FLT1
29	Endothelin-1 Signaling Pathway36	8.9	CSF3, IL2, ANGPT4, ERBB2, TEK, FLT4
30	JNK Pathway36	8.8	KIT, KITLG, PDGFRB, PDGFRA, TEK, TP53
31	Telomerase Components in Cell Signaling36	8.6	TP53, KIT, KITLG, VEGFB, VEGFC, MYC
32	Activation of PKA through GPCR36	8.6	PDGFRB, FLT1, KIT, KITLG, VEGFB, VEGFC
33	Rho Family GTPases36	8.5	CSF3, CSF1, DES, PDGFRB, PDGFRA, TEK
34	p53 Mediated Apoptosis36	8.5	KIT, FLT4, KDR, VEGFB, FIGF, IL2
35	PTEN Pathway36	8.4	KIT, VEGFC, KDR, FLT4, FLT1, KITLG
36	Mitochondrial Apoptosis36	8.3	FIGF, FLT4, FLT1, CDKN2A, KDR, VEGFC
37	Cellular Apoptosis Pathway36	8.3	PDGFRA, KIT, KITLG, VEGFB, VEGFC, CDKN2A
38	Glioma20	8.2	TP53, PTEN, KRAS, PDGFRB, PDGFRA, CCND1
39	Estrogen Pathway36	8.2	FLT1, KDR, VEGFC, VEGFB, BRCA1, KITLG
40	Prostate cancer20	8.2	PTEN, PDGFRA, PDGFRB, KRAS, TP53, ERBB2
41	Melanoma20	8.2	MDM2, CCND1, PIK3CG, KRAS, TP53, CDKN2A
42	ERK Signaling36	8.0	CSF3, VEGFB, KITLG, KIT, VEGFC, PDGFRB
43	Cytokine-cytokine receptor interaction20	8.0	PDGFRB, FLT1, CSF3, FLT4, KDR, VEGFB
44	MAPK Signaling36	7.9	ERBB2, VEGFC, TP53, TEK, PDGFRB, STAT3
45	Bladder cancer20	7.9	FIGF, VEGFA, VEGFB, VEGFC, MYC, CDKN2A
46	p38 Signaling36	7.8	ANGPT1, ANGPT2, IL2, FIGF, FLT4, FLT1
47	JAK-STAT Pathway36	7.7	KIT, IFNA2, ERBB2, TEK, PDGFRA, PDGFRB
48	Pancreatic Adenocarcinoma36	7.3	FIGF, VEGFB, VEGFC, KDR, CDKN2A, FLT1
49	Pathways in cancer20	7.2	STAT3, PIK3CG, HIF1A, KRAS, PDGFRA, PTEN
50	Molecular Mechanisms of Cancer36	7.1	TP53, CCND1, ANGPT4, ANGPT1, ANGPT2, MDM2

Compounds related to angiosarcoma according to GeneDecks:

(show top 50)    (show all 309)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.7	F8
2	threonine32	10.6	MYOD1, KRT8, KRT14, HBA2
3	mucicarmine32	10.1	VIM, MUC1, S100B, CALB2, TP63, KRT20
4	b 72332	10.0	VIM, MUC1, S100B, CALB2, TP63, PDPN
5	vincristine32 34 9 9	12.7	KIT, IFNA1, F8
6	progestin32	9.4	VIM, VEGFA, KDR, CCND1, F8, DES
7	h2o232	9.4	PIK3CG, KITLG, VWF, BRCA1, ATF2, CDKN3
8	aspartate32	9.1	VIM, CHAT, S100B, CDKN2A, F8, ERBB2
9	heparin32 9 18 9	12.1	PIK3CG, KITLG, VWF, SERPINA3, VIM, BRCA1
10	rapamycin32 42	9.6	PIK3CG, KIT, KITLG, VIM, VEGFA, MYOG
11	hematoxylin32	8.5	KIT, VIM, MUC1, S100B, CDKN2A, CD34
12	bromodeoxyuridine32	8.5	KITLG, VIM, MYC, MYOG, MYOD1, S100B
13	erlotinib32 34 9 9	11.5	KIT, VEGFA, KDR, CDKN3, CCND1, ERBB2
14	trastuzumab32 34 9 9	11.5	PIK3CG, KIT, VEGFC, KDR, MUC1, CDKN3
15	arginine32	8.5	VWF, SERPINA3, MYOD1, S100B, CDH5, MME
16	ly29400232	8.3	PIK3CG, VEGFA, MYOG, CDKN3, ANGPT1, CCND1
17	sunitinib32 9 9	10.2	KIT, VEGFA, KDR, FLT1, FLT4, IL2
18	wortmannin32 42	8.9	PIK3CG, KITLG, VIM, KDR, S100B, CDKN3
19	creatinine32	7.9	KITLG, VWF, SERPINA3, VIM, MYOG, MYOD1
20	oxygen32 18	8.8	KITLG, SERPINA3, BRCA1, VEGFB, MYOG, MYOD1
21	lactate32	7.7	KIT, KITLG, VWF, VIM, KDR, CHAT
22	matrigel32	7.6	PIK3CG, VWF, VIM, VEGFA, VEGFC, KDR
23	etoposide32 42 9 9	10.5	PIK3CG, MYC, S100B, CDKN3, MDM2, IFNA2
24	gefitinib32 34 9 9	10.5	PIK3CG, KIT, VIM, VEGFA, KDR, CDKN3
25	estrogen32	7.4	VWF, SERPINA3, BRCA1, VEGFC, MYOG, MYOD1
26	iron32 18	8.4	KITLG, SERPINA3, VIM, S100B, CDKN2A, MDM2
27	cyclosporin a32 42	8.2	PIK3CG, KITLG, VWF, MYC, KDR, S100B
28	carboplatin32 34 9 9	10.1	KITLG, BRCA1, VEGFA, KDR, MDM2, IFNA2
29	steroid32	7.0	KIT, KITLG, SERPINA3, BRCA1, MYOG, MYOD1
30	cytarabine32 34 9 9	9.9	KIT, KITLG, VIM, MYC, MUC1, CDKN2A
31	phosphatidylinositol32	6.7	PIK3CG, KIT, KITLG, BRCA1, VEGFC, MYC
32	imatinib32 34 9 9	9.7	PIK3CG, KIT, KITLG, VEGFA, MYC, KDR
33	gemcitabine32 34 9 9	9.5	BRCA1, VEGFA, MYC, KDR, MUC1, CCND1
34	progesterone32 42 9 18 9	10.5	KIT, SERPINA3, BRCA1, VEGFC, S100B, CDKN2A
35	arsenite32 18	7.2	PIK3CG, VEGFA, MYC, CDKN2A, CDKN3, MDM2
36	adriamycin32	6.0	VIM, BRCA1, MYC, MUC1, CDKN2A, MME
37	oligonucleotide32	5.8	KIT, VWF, SERPINA3, VIM, BRCA1, VEGFC
38	dexamethasone32 42 34 9 9	9.8	KITLG, VWF, SERPINA3, VIM, VEGFA, VEGFC
39	doxorubicin32 34 9 9	8.6	PIK3CG, KIT, KITLG, VIM, BRCA1, KDR
40	docetaxel32 34 9 9	8.4	KIT, BRCA1, VEGFA, MYC, KDR, CDKN2A
41	alanine32	5.2	KITLG, VWF, SERPINA3, VIM, BRCA1, MYC
42	testosterone32 9 18 9	8.0	KIT, KITLG, VWF, VIM, BRCA1, VEGFC
43	thymidine32 18	5.6	KIT, KITLG, BRCA1, VEGFC, MYC, KDR
44	paclitaxel32 34 9 9	7.4	PIK3CG, KIT, KITLG, VIM, BRCA1, VEGFA
45	5fluorouracil32	4.4	PIK3CG, KIT, KITLG, BRCA1, VEGFA, KDR
46	vegf32	3.4	PIK3CG, KIT, KITLG, VWF, BRCA1, VEGFB
47	cycloheximide32	3.3	PIK3CG, KIT, KITLG, VIM, BRCA1, VEGFA
48	tyrosine32	2.4	PIK3CG, KIT, KITLG, VWF, BRCA1, VEGFA
49	serine32	INF	PIK3CG, KIT, KITLG, VWF, SERPINA3, VIM
50	cysteine32	INF	SERPINA3, BRCA1, MYOG, KDR, MUC1, S100B

Cellular components related to angiosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	10.1	DES, KRT14, KRT20, KRT18, KRT8, VIM
2	platelet alpha granule lumen	GO:031093	9.8	PLG, F8, FIGF, VEGFC, VEGFB, VEGFA
3	nuclear body	GO:016604	8.5	TP53, MDM2, CDKN2A, MYC
4	membrane	GO:016020	8.2	GGT1, CSF1, PDGFRB, ESR1, ALPPL2, CCND1
5	extracellular region	GO:005576	7.9	ANGPT2, ANGPT1, ANGPT4, IFNA2, F8, TEK
6	extracellular space	GO:005615	7.5	KIT, ANGPT4, IFNA2, F8, CRP, PLG
7	nucleoplasm	GO:005654	6.5	ESR1, TP53, TP63, KRT8, HIF1A, STAT3
8	cytoplasm	GO:005737	5.5	KRT8, PDGFRB, PDGFRA, PTEN, TEK, TP63
9	nucleus	GO:005634	4.6	ETS1, ESR1, ERBB2, TP53, TP63, TP73
10	plasma membrane	GO:005886	INF	PDGFRA, PLG, PTEN, TEK, ERBB2, ESR1

Biological processes related to angiosarcoma according to GeneDecks:

(show top 50)    (show all 62)

id	Name	GO ID	Score	Top Affiliating Genes
1	Tie receptor signaling pathway	GO:048014	10.7	TEK, ANGPT1, ANGPT2
2	glomerulus vasculature development	GO:072012	10.6	TEK, ANGPT1, ANGPT2
3	sprouting angiogenesis	GO:002040	10.6	FLT1, FLT4, ANGPT1, TEK
4	cell motility	GO:048870	10.6	CD34, ENG, ETS1, FSCN1
5	leukocyte migration	GO:050900	10.5	PECAM1, KRAS, TEK, ANGPT4, ANGPT1, ANGPT2
6	positive regulation of phospholipase C activity	GO:010863	10.5	KIT, FLT1, PDGFRA, PDGFRB
7	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.4	PDGFRB, PDGFRA, TEK, ANGPT1, FLT4, KDR
8	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.4	PDGFRB, PDGFRA, TEK, FLT1, KIT
9	peptidyl-tyrosine phosphorylation	GO:018108	10.4	PDGFRB, PDGFRA, TEK, FLT4, FLT1, KDR
10	cellular response to vascular endothelial growth factor stimulus	GO:035924	10.4	FLT4, VEGFA, KDR, FLT1
11	positive regulation of mast cell chemotaxis	GO:060754	10.4	FIGF, VEGFC, VEGFB, VEGFA
12	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.3	PDGFRB, PDGFRA, TEK, ANGPT1, FLT1, KDR
13	negative regulation of endothelial cell apoptotic process	GO:2000352	10.3	KDR, ANGPT1, TEK
14	induction of positive chemotaxis	GO:050930	10.3	VEGFA, VEGFB, VEGFC, FIGF
15	cell chemotaxis	GO:060326	10.3	PDGFRB, PDGFRA, ENG, KIT
16	positive regulation of blood vessel endothelial cell migration	GO:043536	10.3	ANGPT4, ANGPT1, VEGFC, VEGFA
17	positive chemotaxis	GO:050918	10.3	ANGPT1, FIGF, VEGFC, VEGFB, VEGFA
18	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.3	PDGFRB, PDGFRA, VEGFA
19	positive regulation of endothelial cell migration	GO:010595	10.2	PROX1, TEK, ANGPT4, ANGPT1, FLT4, KDR
20	transmembrane receptor protein tyrosine kinase signaling pathway	GO:007169	10.2	KDR, FLT1, FLT4, ERBB2, TEK
21	cardiac myofibril assembly	GO:055003	10.2	PDGFRA, PDGFRB, ACTC1
22	retina vasculature development in camera-type eye	GO:061298	10.2	HIF1A, PDGFRB, PDGFRA
23	signal transduction by phosphorylation	GO:023014	10.2	KIT, KDR, ERBB2
24	hemopoiesis	GO:030097	10.1	CSF1, ANGPT1, CD34, KITLG, KIT
25	embryonic hemopoiesis	GO:035162	10.1	KIT, KITLG, KDR, HIF1A
26	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.1	PDGFRB, VEGFA, VEGFB, VEGFC, KDR, FLT1
27	lymphangiogenesis	GO:001946	10.0	FLT4, PDPN, PROX1
28	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	10.0	VEGFA, VEGFB, FLT1, HIF1A
29	protein autophosphorylation	GO:046777	10.0	PDGFRB, PDGFRA, TEK, ERBB2, FLT4, FLT1
30	positive regulation of endothelial cell proliferation	GO:001938	10.0	PROX1, HIF1A, TEK, FLT4, KDR, VEGFB
31	platelet degranulation	GO:002576	10.0	PECAM1, PLG, F8, FIGF, VEGFC, VEGFB
32	positive regulation of cell migration	GO:030335	10.0	CSF1, PDPN, PDGFRB, PDGFRA, ETS1, FLT1
33	positive regulation of angiogenesis	GO:045766	9.9	HIF1A, TEK, ETS1, ANGPT4, ANGPT2, FLT1
34	anti-apoptosis	GO:006916	9.8	TEK, ETS1, ANGPT4, ANGPT1, IL2, MUC1
35	platelet activation	GO:030168	9.7	PECAM1, PLG, F8, FIGF, VEGFC, VEGFB
36	positive regulation of MAP kinase activity	GO:043406	9.6	KRAS, PDGFRB, ERBB2, FLT1, VEGFA, KITLG
37	positive regulation of protein phosphorylation	GO:001934	9.5	KRAS, TEK, ERBB2, CCND1, ENG, FLT4
38	phosphatidylinositol-mediated signaling	GO:048015	9.5	PDGFRB, PDGFRA, PTEN, ERBB2, MDM2
39	angiogenesis	GO:001525	9.4	ANXA2, TEK, PTEN, HIF1A, TIE1, ANGPT4
40	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.3	TP53, ANGPT4, ANGPT1, VEGFB, VEGFA, KITLG
41	response to hypoxia	GO:001666	9.2	HIF1A, CRP, ETS1, ANGPT1, ANGPT2, ENG
42	inflammatory response	GO:006954	9.1	CSF1, PDPN, CRP, TP73, IFNA2, SERPINA3
43	cellular response to hypoxia	GO:071456	8.9	HIF1A, TP53, ANGPT4, MDM2, VEGFA
44	cell proliferation	GO:008283	8.7	CSF1, STAT3, PDPN, PTEN, TP53, ERBB2
45	signal transduction	GO:007165	8.6	PECAM1, STAT3, TIE1, HIF1A, PDPN, PDGFRB
46	negative regulation of apoptotic process	GO:043066	8.6	KRT18, PTEN, TEK, TP53, ANGPT4, ANGPT1
47	blood coagulation	GO:007596	8.4	IFNA2, F8, TP53, TEK, PLG, KRAS
48	positive regulation of cell proliferation	GO:008284	8.3	PROX1, CSF1, CSF3, KRAS, PDGFRB, PDGFRA
49	positive regulation of transcription, DNA-dependent	GO:045893	7.9	PROX1, STAT3, HIF1A, TP73, TP63, TP53
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.7	ESR1, TP53, TP63, TP73, HIF1A, STAT3

Molecular functions related to angiosarcoma according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor binding	GO:038085	10.5	KDR, PDGFRA, PDGFRB
2	vascular endothelial growth factor-activated receptor activity	GO:005021	10.5	PDGFRB, PDGFRA, FLT4, FLT1, KDR
3	chemoattractant activity	GO:042056	10.2	FIGF, VEGFC, VEGFB, VEGFA
4	platelet-derived growth factor receptor binding	GO:005161	10.1	PDGFRB, PDGFRA, FIGF, VEGFA
5	growth factor binding	GO:019838	10.1	ERBB2, FLT4, FLT1, KDR
6	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.1	TIE1, PDGFRA, TEK, ERBB2, FLT4, FLT1
7	choline binding	GO:033265	10.0	ACPP, CRP, CHAT
8	receptor signaling protein tyrosine kinase activity	GO:004716	9.9	KIT, KDR, ERBB2
9	protein tyrosine kinase activity	GO:004713	9.5	PDGFRB, TEK, ERBB2, KDR, KIT
10	growth factor activity	GO:008083	9.3	CSF3, CSF1, IL2, FIGF, VEGFC, VEGFB
11	cytokine activity	GO:005125	8.9	KITLG, VEGFA, IL2, IFNA2, CSF1, CSF3
12	protein homodimerization activity	GO:042803	8.8	CSF1, TKT, PDGFRA, CRP, ENG, FIGF
13	transcription regulatory region DNA binding	GO:044212	8.7	PROX1, STAT3, HIF1A, TP73, TP63, TP53
14	transcription factor binding	GO:008134	8.4	STAT3, HIF1A, TP73, TP53, ETS1, CD34
15	identical protein binding	GO:042802	8.2	TP73, TP63, TP53, ERBB2, ESR1, MDM2
16	protein heterodimerization activity	GO:046982	8.2	HIF1A, TP53, ERBB2, MYOD1, MYOG, MYC
17	protein kinase binding	GO:019901	8.0	STAT3, HIF1A, PTEN, TP73, TP53, CCND1
18	enzyme binding	GO:019899	7.6	CSF3, HIF1A, PTEN, TP53, ESR1, CCND1
19	protein binding	GO:005515	1.7	GGT1, PDGFRA, PLG, CRP, PTEN, TEK