MCID: ANG020
MIFTS: 61

Angiosarcoma malady

Cancer diseases category

Summaries for Angiosarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.

MalaCards: Angiosarcoma, also known as hemangiosarcoma, is related to sarcoma and lymphedema. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Tyrosine Kinases / Adaptors and VEGF Signaling Pathway. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include breast, endothelial and liver, and related mouse phenotypes are muscle and integument.

Wikipedia:63 Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may... more...

Aliases & Classifications for Angiosarcoma

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8Disease Ontology, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
angiosarcoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

angiosarcoma 8 44 48
hemangiosarcoma 8 60
hemangioendothelioma, malignant 8
malignant hemangioendothelioma 44
primary hemangiosarcoma 8


External Ids:

Disease Ontology8 DOID:0001816
NCIt39 C3088
MeSH34 D006394
SNOMED-CT via Orphanet57 403977003, 39000009

Related Diseases for Angiosarcoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Angiosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.5FLI1, CALB2, VIM, FLT4, ANGPT2, MUC1
2lymphedema30.4VEGFC, PROX1, FLT4, PDPN
3hemangioma30.4PECAM1, ACTC1, KDR, CD34, ANGPT2, PROX1
4breast cancer30.3VEGFC, PROX1, FLT4, FLI1, PDPN, TIE1
5kaposi's sarcoma30.2PDPN, FLI1, FLT4, VEGFC, CD34, KDR
6lymphangiosarcoma30.2PROX1
7squamous cell carcinoma30.2KRT14, KDR, FSCN1, CD34, MUC1, ANGPT2
8thrombocytopenia30.1FLI1, CD34, PECAM1
9lipoma30.0CD34
10fibrous histiocytoma29.9CD34
11hemangiopericytoma29.9VIM, MUC1, CD34, ACTC1
12epithelioid sarcoma29.9VIM, CALB2, MUC1, CDH5, CD34
13epithelioid hemangioendothelioma29.9FLT4, CD34
14adenoma29.9ACTC1, KRT14, FSCN1, MUC1, ANGPT2, FLT4
15malignant peripheral nerve sheath tumor29.9VIM, CALB2, CD34
16adenocarcinoma29.9VIM, TIE1, CALB2, PDPN, FLI1, PECAM1
17adenosarcoma29.9ACTC1
18liposarcoma29.8CD34, FLI1, CALB2, VIM
19fibrosarcoma29.8ACTC1, CD34, VIM
20colon cancer29.8CALB2, FLT4, FSCN1, KDR
21peritonitis29.7PECAM1
22cystadenoma29.7VEGFC
23hemangioendothelioma29.7CD34, FLT4, FLI1
24cystadenocarcinoma29.7MUC1
25leiomyoma29.7ACTC1, CD34, VIM
26gastrointestinal stromal tumor29.7ACTC1, KDR, CD34, VIM
27ischemia29.7TIE1, VEGFC, ANGPT2, KDR, PECAM1
28neurofibroma29.7VIM, MUC1, CD34, ACTC1
29peripheral primitive neuroectodermal tumor29.7FLI1
30papillary carcinoma29.7CALB2, VEGFC, MUC1, KRT14, ACTC1
31cervical cancer29.7KRT14, VEGFC, FLT4, PDPN
32malignant mesothelioma29.7VIM, CALB2, PDPN, FLT4, MUC1, KDR
33leiomyosarcoma29.7ACTC1, CD34, MUC1, CALB2, VIM
34malignant pleural mesothelioma29.7CALB2
35chondrosarcoma29.7SERPINA3, MUC1, VIM
36lymphangioleiomyomatosis29.7VEGFC
37ovarian cancer29.7CALB2, FLT4, VEGFC, MUC1, FSCN1, KDR
38brain cancer29.7ANGPT2, CDH5, KDR, PECAM1
39melanoma29.7PECAM1, SERPINA3, ACTC1, FLT4, VEGFC, ANGPT2
40cutaneous fibrous histiocytoma29.7CD34
41transitional cell carcinoma29.7KRT14, VEGFC, CALB2
42pneumonia29.7MUC1, VEGFC
43breast angiosarcoma10.7
44liver angiosarcoma10.6
45hepatitis10.4
46ovarian angiosarcoma10.4
47skin angiosarcoma10.4
48spleen angiosarcoma10.4
49thyroid angiosarcoma10.3
50hepatitis a10.3

Graphical network of the top 20 diseases related to Angiosarcoma:



Diseases related to angiosarcoma

Clinical Features for Angiosarcoma

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Drugs & Therapeutics for Angiosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Angiosarcoma

Drug clinical trials:

Search ClinicalTrials for Angiosarcoma

Search NIH Clinical Center for Angiosarcoma

Search CenterWatch for Angiosarcoma

Genetic Tests for Angiosarcoma

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Anatomical Context for Angiosarcoma

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32MalaCards
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MalaCards organs/tissues related to Angiosarcoma:

32
Breast, Endothelial, Liver, Bone, Lung, Skin, Spleen, Thyroid, Heart, Ovary, Colon, Small intestine, Adrenal gland, Lymph node, Kidney, Prostate, Bone marrow, Uterus, Pancreas, Brain, Tongue, Cervix, Tonsil, T cells

Animal Models for Angiosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiosarcoma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.6TIE1, FLI1, KDR, SLC6A6, ACTC1
2MP:001077110.6TIE1, ANGPT2, CD34, KDR, KRT14
3MP:000537610.6PDPN, PROX1, CD34, SLC6A6, KRT14, ACTC1
4MP:000538510.5PECAM1, VIM, TIE1, PDPN, FLI1, FLT4
5MP:000538110.5TIE1, PDPN, FLT4, PROX1, ANGPT2, MUC1
6MP:000539110.5VIM, PROX1, ANGPT2, MUC1, SLC6A6, KRT14
7MP:000538710.4PROX1, FLT4, FLI1, PDPN, TIE1, VIM
8MP:000537010.4FLT4, PROX1, MUC1, KDR, PECAM1, FLI1
9MP:000538410.3VIM, TIE1, FLI1, PROX1, CDH5, CD34
10MP:000538810.3TIE1, PDPN, PROX1, KDR, KRT14, PECAM1
11MP:001076810.3FLT4, FLI1, PDPN, TIE1, VIM, PROX1
12MP:000537810.0VIM, TIE1, PDPN, FLI1, FLT4, PROX1

Publications for Angiosarcoma

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50PubMed
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Articles related to Angiosarcoma:

(show top 50)    (show all 684)
idTitleAuthorsYear
1
Cardiopulmonary thromboembolism of epithelioid angiosarcoma arising from malignant phyllodes tumour of the breast. (24399035)
2014
2
Metastatic epithelioid angiosarcoma to the mandible: report of a case and review of the literature. (23499149)
2013
3
Angiosarcoma of the humerus presenting with fluid-fluid levels on MRI: a unique imaging presentation. (23722293)
2013
4
Primary cardiac angiosarcoma in a 25-year-old man: excision, adjuvant chemotherapy, and multikinase inhibitor therapy. (23678219)
2013
5
Primary angiosarcoma of the breast: a case report. (23607567)
2013
6
Therapy of radiation-induced angiosarcoma of the breast in an elderly patient. (23008109)
2013
7
Primary angiosarcoma of breast: A case report. (23466684)
2013
8
Cardiac angiosarcoma management and outcomes: 20-year single-institution experience. (22476752)
2012
9
Littoral cell angioma and angiosarcoma of the spleen: report of two cases in siblings and review of the literature. (22068970)
2012
10
Cardiac angiosarcoma: an unusual cause of coronary artery pseudoaneurysm. (21364473)
2012
11
Cutaneous angiosarcoma of the scalp masquerading as a squamous cell carcinoma: case report and literature review. (22713442)
2012
12
A rare angiosarcoma: retiform haemangioendothelioma. (21888747)
2012
13
Cardiac angiosarcoma discovered at a pacemaker implantation procedure. (23391809)
2012
14
Clinical and pharmacologic evaluation of two dose levels of intetumumab (CNTO 95) in patients with melanoma or angiosarcoma. (21331745)
2012
15
Metabolic activity assessment of cardiac angiosarcoma by 18FDG PET-CT. (23047579)
2012
16
Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate. (22308113)
2012
17
Primary tracheal angiosarcoma. (23284129)
2012
18
Breast angiosarcoma secondary to phyllodes tumour. (23208815)
2012
19
Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report. (23134683)
2012
20
Angiosarcoma-like presentation of pacemaker-related vascular proliferation. (22106983)
2012
21
Dermoscopy pattern of cutaneous angiosarcoma. (21300608)
2011
22
A case of angiosarcoma arising on a closed shunt in a patient with chronic renal failure. (21920251)
2011
23
Hispanic with a primary pulmonary angiosarcoma: case report and literature review. (22737828)
2011
24
Angiosarcoma in an obese woman with worsening lymphedema after weight-loss and skin-reduction surgeries. (21763582)
2011
25
Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions. (20949568)
2011
26
Successful treatment of an angiosarcoma of the head - options for systemic therapy. (21122067)
2011
27
Radically resected epithelioid angiosarcoma that originated in the mediastinum. (21751114)
2011
28
A large angiosarcoma of the right atrium: anaesthetic management. (21642079)
2011
29
F18-FDG PET/CT Scanning in Angiosarcoma: Report of Two Cases. (23486298)
2011
30
Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma. (19836053)
2010
31
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
32
Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing to the serous membrane. (20661412)
2010
33
Hepatic angiosarcoma arising in an adult mesenchymal hamartoma. (20551545)
2010
34
Angiosarcoma of the lung: 2 cases report and literature reviewed. (20952087)
2010
35
Primary angiosarcoma of the breast in a postmenopausal patient. (20479566)
2010
36
Primary angiosarcoma of the pulmonary trunk mimicking pulmonary thromboembolism. (20380673)
2010
37
Breast Angiosarcoma: Case Series and Expression of Vascular Endothelial Growth Factor. (20737044)
2009
38
Intraosseous angiosarcoma with secondary aneurysmal bone cysts presenting as an elusive diagnostic challenge. (18492283)
2008
39
Mutation of the PTEN gene in a human hepatic angiosarcoma. (17954274)
2007
40
Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67. (17425381)
2007
41
Angiostatin receptor annexin II in vascular tumors including angiosarcoma. (17239928)
2007
42
Primary ovarian angiosarcoma--review of the literature and report of a case with coexisting chylothorax. (17713094)
2007
43
Clinical and pathologic characteristics of primary angiosarcoma of breast]. (17134567)
2006
44
Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma. (12218574)
2002
45
Cutaneous breast angiosarcoma after conserving treatment of breast cancer. (11701414)
2001
46
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. (10964802)
2000
47
Primary ovarian angiosarcoma: a case report and literature review. (9952341)
1998
48
Two new cases of liver angiosarcoma: history and perspectives of liver angiosarcoma among plastic industry workers. (9284534)
1997
49
Aicardi syndrome, metastatic angiosarcoma of the leg, and scalp lipoma. (8456830)
1993
50
Malignant tumour of skin--angiosarcoma. (7197263)
1981

Genetic Variations for Angiosarcoma

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Expression for genes affiliated with Angiosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiosarcoma

Search GEO for disease gene expression data for Angiosarcoma.

Pathways for genes affiliated with Angiosarcoma

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Sources:
4Cell Signaling Technology, 49PharmGKB, 55SinoBiological, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Angiosarcoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9CALB2
2dexamethasone44 49 28 1113.9VEGFC, KDR, ANGPT2
3reticulin4410.8CD34, MUC1, VIM, ACTC1
4s 1004410.8VIM, ACTC1, MUC1
5ribonucleic acid4410.8MUC1, PECAM1, ACTC1, CDH5, VEGFC, ANGPT2
6vegfc2810.8FLT4, KDR
7sialic acid4410.8PECAM1
8trastuzumab44 49 1112.8VEGFC, ANGPT2, KDR, MUC1
9mucicarmine4410.8KRT14, VIM, MUC1, CALB2, ACTC1
102-methoxyethanol4410.8VIM, KRT14, ACTC1
11vegfe2810.8KDR, FLT4
12hydrocortisone44 2 59 1113.8MUC1, VIM, CDH5, KDR, KRT14
13b 7234410.8VIM, CALB2, PDPN, ACTC1, MUC1
14matrigel4410.8PECAM1, ACTC1, CDH5, MUC1, ANGPT2, VEGFC
15glucose4410.8SERPINA3, ACTC1, KRT14, CDH5, VEGFC, ANGPT2
16azd 21714410.8FLT4, KDR
17progestin4410.8MUC1, ANGPT2, VIM, KDR
18serine4410.8PECAM1, KRT14, SLC6A6, FSCN1, SERPINA3
19oxygen44 2411.8SERPINA3, MUC1, ANGPT2, VEGFC, FLT4, PECAM1
20thymidine44 2411.8KDR, CD34, MUC1, ANGPT2, VEGFC, CALB2
21agar4410.8VIM, CD34, KDR, PECAM1, MUC1
22hematoxylin4410.8PECAM1, ACTC1, KRT14, CD34, MUC1, PDPN
23nitric oxide44 11 2412.7ANGPT2, MUC1, CDH5, TIE1, KDR, CALB2
24polysaccharide4410.7CDH5, PDPN, SERPINA3, KDR, MUC1
25progesterone44 59 28 11 2414.7KRT14, CD34, VEGFC, SERPINA3, CALB2, MUC1
26formaldehyde44 2411.7PECAM1, ACTC1, MUC1, VIM
27orcein4410.7VIM, ACTC1
28folate4410.7SERPINA3, KDR, MUC1, VIM
29estradiol44 11 2412.7VEGFC, CDH5, VIM, SERPINA3, MUC1
30cysteine4410.7PECAM1, SERPINA3, SLC6A6, KDR, MUC1, ANGPT2
31retinoic acid44 2411.7PECAM1, CD34, FSCN1, KDR, MUC1, FLT4
32creatinine4410.7SERPINA3, ACTC1, ANGPT2
33vegf4410.7ANGPT2, VIM, TIE1, VEGFC, PECAM1, ACTC1
34eosin4410.7VIM, MUC1
35heparin44 28 11 2413.7PECAM1, SERPINA3
36zd64744410.7KDR, FLT4
37calcium44 49 11 2413.7PECAM1, SERPINA3, CALB2, VEGFC, ANGPT2, MUC1
38lipid4410.7VIM, VEGFC, MUC1, CDH5, KRT14, SERPINA3
39tyrosine4410.6FSCN1, KDR, TIE1, ACTC1, ANGPT2, KRT14
40paraffin4410.6CD34, PECAM1, SERPINA3, KRT14, FSCN1, ACTC1
41axitinib44 59 1112.6KDR, FLT4
4212-o-tetradecanoylphorbol 13-acetate4410.6FSCN1, VIM, CD34, MUC1
43butyrate4410.6CALB2
44silver4410.5CALB2, CD34, SERPINA3
45tamoxifen44 49 28 1113.5KRT14, KDR, VIM, MUC1
46rapamycin4410.4VIM, PECAM1, FLT4, KDR
47paclitaxel44 49 1112.4KDR, FLT4, CALB2
48fibrinogen4410.3PECAM1, CDH5, ANGPT2, SERPINA3
49testosterone44 59 11 2413.1ACTC1, MUC1, VIM, CALB2, VEGFC

GO Terms for genes affiliated with Angiosarcoma

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16Gene Ontology
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Cellular components related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.3SLC6A6, KDR, CD34, MUC1, FLT4, PDPN

Biological processes related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor signaling pathwayGO:04801010.7KDR, VEGFC, FLT4
2lymphangiogenesisGO:00194610.7PDPN, FLT4, PROX1
3positive regulation of endothelial cell migrationGO:01059510.7PROX1, KDR, FLT4
4glomerular endothelium developmentGO:07201110.7CD34, PECAM1
5endothelium developmentGO:00315810.6KDR, CD34
6skeletal muscle thin filament assemblyGO:03024010.6ACTC1, PROX1
7positive regulation of endothelial cell proliferationGO:00193810.6KDR, PROX1, FLT4
8angiogenesisGO:00152510.5TIE1, VEGFC, ANGPT2, KDR
9positive regulation of vasculogenesisGO:200121410.5KDR, CD34
10lymph vessel developmentGO:00194510.5KDR, FLT4
11leukocyte migrationGO:05090010.4PECAM1, CD34, ANGPT2
12signal transductionGO:00716510.3PECAM1, CD34, ANGPT2, VEGFC, PDPN, TIE1
13positive regulation of angiogenesisGO:04576610.1ANGPT2, CD34, KDR

Molecular functions related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:00502110.4FLT4, KDR
2transmembrane receptor protein tyrosine kinase activityGO:00471410.3KDR, FLT4, TIE1
3protein bindingGO:0055159.9MUC1, ANGPT2, VEGFC, PROX1, FLT4, TIE1

Products for genes affiliated with Angiosarcoma

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  • Antibodies
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Sources for Angiosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet