MCID: ANG020
MIFTS: 58

Angiosarcoma malady

Cancer category

Summaries for Angiosarcoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A malignant vascular tumor that results in rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and derived from the lining of irregular blood-filled spaces.

MalaCards: Angiosarcoma, also known as hemangiosarcoma, is related to hemangioendothelioma and kaposi's sarcoma. An important gene associated with Angiosarcoma is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Tyrosine Kinases / Adaptors and VEGF Signaling Pathway. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are muscle and integument.

Wikipedia:64 Angiosarcoma is a malignant neoplasm (cancer) of endothelial-type cells that line vessel walls. This may... more...

Aliases & Classifications for Angiosarcoma

Sources:
8Disease Ontology, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Characteristics (Orphanet epidemiological data):

49
angiosarcoma:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood


Aliases & Descriptions:

angiosarcoma 8 45 49
hemangiosarcoma 8 61
hemangioendothelioma, malignant 8
malignant hemangioendothelioma 45
primary hemangiosarcoma 8


External Ids:

Disease Ontology8 DOID:0001816
NCIt40 C3088
MeSH35 D006394

Related Diseases for Angiosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Angiosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1hemangioendothelioma30.5CD34, FLT4, FLI1
2kaposi's sarcoma30.4PDPN, FLI1, FLT4, VEGFC, CD34, KDR
3epithelioid hemangioendothelioma30.4FLT4, CD34
4teratoma30.2ACTC1, PDPN
5lymphangiosarcoma30.2PROX1
6squamous cell carcinoma30.2KRT14, KDR, FSCN1, CD34, MUC1, ANGPT2
7thrombocytopenia30.2FLI1, CD34, PECAM1
8pyogenic granuloma30.1FLT4, ANGPT2, CD34, ACTC1, PECAM1
9fibrous histiocytoma29.9CD34
10lymphedema, congenital29.9PDPN, FLT4, VEGFC
11adenoma29.9ACTC1, KRT14, FSCN1, MUC1, ANGPT2, FLT4
12adenocarcinoma29.9VIM, TIE1, CALB2, PDPN, FLI1, PECAM1
13adenosarcoma29.9ACTC1
14cystadenoma29.7VEGFC
15gastrointestinal stromal tumor29.7ACTC1, KDR, CD34, VIM
16papillary carcinoma29.7CALB2, VEGFC, MUC1, KRT14, ACTC1
17lymphangioleiomyomatosis29.7VEGFC
18brain cancer29.7ANGPT2, CDH5, KDR, PECAM1
19cutaneous fibrous histiocytoma29.7CD34
20transitional cell carcinoma29.7KRT14, VEGFC, CALB2
21breast angiosarcoma10.8
22liver angiosarcoma10.6
23ovarian angiosarcoma10.4
24skin angiosarcoma10.4
25spleen angiosarcoma10.4
26thyroid angiosarcoma10.4
27pediatric angiosarcoma10.3
28xeroderma pigmentosum10.3
29aorta angiosarcoma10.3
30prostate angiosarcoma10.3
31cardiac tamponade10.2
32conventional angiosarcoma10.2
33cardiac rupture10.2
34radiation induced angiosarcoma of the breast10.2
35central nervous system angiosarcoma10.2
36gallbladder angiosarcoma10.2
37mediastinum angiosarcoma10.2
38superior vena cava angiosarcoma10.1
39aortic aneurysm10.1
40angiosarcoma of the scalp10.1
41adenoid squamous cell carcinoma10.1
42intravascular papillary endothelial hyperplasia10.1
43diffuse alveolar hemorrhage10.1
44thyroid adenoma10.0
45discoid lupus erythematosus10.0
46peritonitis10.0PECAM1
47kidney cancer10.0PDPN
48histiocytosis10.0FSCN1
49capillary hemangioma10.0CD34
50arthritis10.0PECAM1, SERPINA3

Graphical network of the top 20 diseases related to Angiosarcoma:



Diseases related to angiosarcoma

Clinical Features for Angiosarcoma

Drugs & Therapeutics for Angiosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Angiosarcoma

Drug clinical trials:

Search ClinicalTrials for Angiosarcoma

Search NIH Clinical Center for Angiosarcoma

Search CenterWatch for Angiosarcoma

Genetic Tests for Angiosarcoma

Anatomical Context for Angiosarcoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Angiosarcoma:

33
Skin, Ovary, Liver, Tongue, Brain, Kidney, Lymph node, Lung, Spleen, Uterus, Bone marrow, Heart, Small intestine, Colon, Pancreas, Thyroid, Adrenal gland, Breast, Prostate, Cervix, Tonsil, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Angiosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Angiosarcoma

Sources:
51PubMed
See all sources

Articles related to Angiosarcoma:

(show top 50)    (show all 690)
idTitleAuthorsYear
1
Angiosarcoma of the scalp. (24367872)
2013
2
Rupture of splenic angiosarcoma: a rare cause of spontaneous haemoperitoneum. (23709556)
2013
3
Primary Hepatic Angiosarcoma and Potential Treatment Options. (24372769)
2013
4
Ultrasound challenge: secondary breast angiosarcoma mimicking lipoma. (23701498)
2013
5
ROCK1 &amp; 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression. (22934846)
2013
6
Post-radiation Atypical Vascular Lesion/Angiosarcoma Arising in the Larynx. (24310944)
2013
7
Primary Angiosarcoma of Bone: A Retrospective Analysis of 60 Patients From 2 Institutions. (23466575)
2013
8
Various colour gradations as a dermatoscopic feature of cutaneous angiosarcoma of the scalp. (22458422)
2013
9
CD8(+) tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma. (24243586)
2013
10
Primary pulmonary angiosarcoma, an exceptional neoplasm with a poor prognosis: reports of two cases and review of the literature. (23306901)
2013
11
Colonic angiosarcoma: a rare cause of bleeding. (22507877)
2012
12
MRI findings of large low-grade angiosarcoma of the breast with subsequent bone metastases: a case report. (22807947)
2012
13
Primary de novo angiosarcoma of the pleura. (22365000)
2012
14
Prostate angiosarcoma: is there any association with previous radiation therapy? (22583810)
2012
15
Sorafenib for patients with advanced angiosarcoma: a phase II Trial from the French Sarcoma Group (GSF/GETO). (22285963)
2012
16
Urgent surgery in a Kasabach-Merrit syndrome associated with a giant hepatic angiosarcoma. (23083765)
2012
17
Primary pulmonary epithelioid angiosarcoma presenting as a solitary pulmonary nodule on image. (22612512)
2012
18
Adrenal epithelioid angiosarcoma metastatic to the epicardium: diagnosis by 18F-FDG PET/CT. (22889791)
2012
19
Partial response of angiosarcoma of the scalp to sorafenib: association with decreased expression of vascular endothelial growth factors and their receptors. (22369131)
2012
20
Successful treatment of an angiosarcoma of the nose with radiation therapy. (23185161)
2012
21
Upper gastrointestinal hemorrhage caused by duodenal angiosarcoma. (22546097)
2012
22
Gingival metastasis of a radiotherapy-induced breast angiosarcoma: diagnosis and multidisciplinary treatment achieving a prolonged complete remission. (22890085)
2012
23
Primary breast angiosarcoma: avoiding a common trap. (22611503)
2011
24
Primary angiosarcoma of the thyroid gland in an young Iranian woman. (22693296)
2011
25
Bilateral angiosarcoma of breast in a young lady. (22557784)
2011
26
Incidental identification of right atrial mass using bedside ultrasound: cardiac angiosarcoma. (22224142)
2011
27
Metastatic angiosarcoma arising from the right atrium: unusual presentation and excellent response to treatment in a young patient. (20661090)
2010
28
Angiosarcoma of the eyelid: a clinicopathologic comparison between isolated unilateral tumors and tumors demonstrating extrapalpebral involvement. (20559124)
2010
29
Cardiac angiosarcoma and recurrent pericardial effusion. (20622718)
2010
30
Radiology quiz case 1. Metastatic cutaneous angiosarcoma of the scalp with perineural spread. (20403861)
2010
31
Epithelioid angiosarcoma of the scapula. (20952750)
2010
32
Primary epithelioid angiosarcoma of bone: a case report with immunohistochemical study. (21045426)
2010
33
Primary colonic angiosarcoma as a cause of massive lower gastrointestinal bleeding. (20486756)
2010
34
Microangiopathic haemolytic anaemia and hyposplenism in angiosarcoma. (21029068)
2010
35
Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. (19696615)
2009
36
Paclitaxel-dependent prolonged and persistent complete remission four years from first recurrence of secondary breast angiosarcoma. (20210253)
2009
37
Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. (17720094)
2007
38
Epithelioid angiosarcoma arising in a deep-seated plexiform schwannoma: a case report and literature review. (17574948)
2007
39
Bilateral massive bloody pleurisy complicated by angiosarcoma. (17268128)
2007
40
Expression of human herpesvirus 8 (HHV-8), latent nuclear antigen 1 (LANA1) in angiosarcoma in acquired immunodeficiency syndrome (AIDS) - a report of two cases. (18042074)
2007
41
Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases. (11145248)
2001
42
KIT expression in angiosarcomas and fetal endothelial cells: lack of mutations of exon 11 and exon 17 of C-kit. (10824925)
2000
43
Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. (10854238)
2000
44
VEGF and its receptors are expressed in a pediatric angiosarcoma in a patient with Aicardi's syndrome. (10844570)
2000
45
Oral angiosarcoma misdiagnosed as a pyogenic granuloma. (9580135)
1998
46
Gliosarcoma with angiosarcomatous features: a case report. (10328547)
1998
47
Primary angiosarcoma of the spleen. A clinicopathologic study of 40 cases. (8372948)
1993
48
Intravascular papillary endothelial hyperplasia in the maxillary sinus. A benign lesion that may be mistaken for angiosarcoma. (1910709)
1991
49
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. (1793483)
1991
50
Angiosarcoma: report of three cases of postmastectomy lymphangiosarcoma and one of hemangiosarcoma. (4734252)
1973

Genetic Variations for Angiosarcoma

Expression for genes affiliated with Angiosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Angiosarcoma

Search GEO for disease gene expression data for Angiosarcoma.

Pathways for genes affiliated with Angiosarcoma

Sources:
4Cell Signaling Technology, 50PharmGKB, 56SinoBiological, 54Reactome, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Compounds for genes affiliated with Angiosarcoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1estrogen4510.9CALB2
2dexamethasone45 50 29 1113.9KDR, ANGPT2, VEGFC
3reticulin4510.8VIM, MUC1, CD34, ACTC1
4s 1004510.8VIM, MUC1, ACTC1
5ribonucleic acid4510.8VEGFC, ANGPT2, MUC1, CDH5, ACTC1, PECAM1
6vegfe2910.8FLT4, KDR
7sialic acid4510.8PECAM1
8trastuzumab45 50 1112.8VEGFC, ANGPT2, MUC1, KDR
9mucicarmine4510.8VIM, CALB2, MUC1, KRT14, ACTC1
102-methoxyethanol4510.8ACTC1, KRT14, VIM
11vegfc2910.8FLT4, KDR
12hydrocortisone45 2 60 1113.8VIM, MUC1, CDH5, KDR, KRT14
13b 7234510.8ACTC1, MUC1, PDPN, CALB2, VIM
14matrigel4510.8FLT4, VEGFC, ANGPT2, MUC1, CDH5, KDR
15glucose4510.8VEGFC, ANGPT2, MUC1, CDH5, KRT14, ACTC1
16azd 21714510.8FLT4, KDR
17progestin4510.8KDR, MUC1, ANGPT2, VIM
18serine4510.8PECAM1, SERPINA3, KRT14, SLC6A6, FSCN1
19oxygen45 2411.8FLT4, VEGFC, ANGPT2, MUC1, CDH5, SERPINA3
20thymidine45 2411.8CALB2, VEGFC, ANGPT2, MUC1, CD34, KDR
21agar4510.8VIM, MUC1, CD34, KDR, PECAM1
22hematoxylin4510.8PECAM1, ACTC1, KRT14, CD34, MUC1, PDPN
23nitric oxide45 11 2412.7TIE1, CALB2, VEGFC, ANGPT2, MUC1, CDH5
24polysaccharide4510.7SERPINA3, KDR, CDH5, MUC1, PDPN
25progesterone45 60 29 11 2414.7VIM, CALB2, VEGFC, MUC1, CD34, KRT14
26formaldehyde45 2411.7PECAM1, ACTC1, MUC1, VIM
27orcein4510.7ACTC1, VIM
28folate4510.7SERPINA3, KDR, MUC1, VIM
29estradiol45 11 2412.7VIM, VEGFC, MUC1, CDH5, SERPINA3
30cysteine4510.7VIM, ANGPT2, MUC1, KDR, SLC6A6, KRT14
31retinoic acid45 2411.7PECAM1, VIM, FLT4, VEGFC, ANGPT2, MUC1
32creatinine4510.7ANGPT2, ACTC1, SERPINA3
33vegf4510.7VIM, TIE1, PDPN, FLT4, PECAM1, ACTC1
34eosin4510.7MUC1, VIM
35heparin45 29 11 2413.7PECAM1, SERPINA3
36zd64744510.7FLT4, KDR
37calcium45 50 11 2413.7CALB2, VEGFC, ANGPT2, MUC1, CDH5, FSCN1
38lipid4510.7VIM, VEGFC, MUC1, CDH5, KRT14, SERPINA3
39tyrosine4510.6ANGPT2, VEGFC, FLT4, PDPN, CALB2, TIE1
40paraffin4510.6PECAM1, VIM, CALB2, PDPN, FLT4, VEGFC
41axitinib45 60 1112.6KDR, FLT4
4212-o-tetradecanoylphorbol 13-acetate4510.6FSCN1, CD34, MUC1, VIM
43butyrate4510.6CALB2
44silver4510.5CALB2, CD34, SERPINA3
45tamoxifen45 50 29 1113.5KRT14, KDR, MUC1, VIM
46rapamycin4510.4PECAM1, KDR, FLT4, VIM
47paclitaxel45 50 1112.4CALB2, FLT4, KDR
48fibrinogen4510.3PECAM1, SERPINA3, CDH5, ANGPT2
49testosterone45 60 11 2413.1VIM, CALB2, VEGFC, MUC1, ACTC1

GO Terms for genes affiliated with Angiosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.3SLC6A6, KDR, CD34, MUC1, FLT4, PDPN

Biological processes related to Angiosarcoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor signaling pathwayGO:04801010.7FLT4, VEGFC, KDR
2lymphangiogenesisGO:00194610.7PROX1, FLT4, PDPN
3positive regulation of endothelial cell migrationGO:01059510.7KDR, PROX1, FLT4
4glomerular endothelium developmentGO:07201110.7CD34, PECAM1
5endothelium developmentGO:00315810.6CD34, KDR
6skeletal muscle thin filament assemblyGO:03024010.6ACTC1, PROX1
7positive regulation of endothelial cell proliferationGO:00193810.6KDR, PROX1, FLT4
8angiogenesisGO:00152510.5TIE1, VEGFC, ANGPT2, KDR
9lymph vessel developmentGO:00194510.5KDR, FLT4
10positive regulation of vasculogenesisGO:200121410.4KDR, CD34
11leukocyte migrationGO:05090010.4PECAM1, CD34, ANGPT2
12signal transductionGO:00716510.3TIE1, PDPN, VEGFC, ANGPT2, CD34, PECAM1
13positive regulation of angiogenesisGO:04576610.1KDR, CD34, ANGPT2

Molecular functions related to Angiosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:00502110.4KDR, FLT4
2transmembrane receptor protein tyrosine kinase activityGO:00471410.3KDR, FLT4, TIE1
3protein bindingGO:0055159.9VIM, TIE1, FLT4, PROX1, VEGFC, ANGPT2

Products for genes affiliated with Angiosarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angiosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet