MCID: ANG002
MIFTS: 44

Angiostrongyliasis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Angiostrongyliasis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 60UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Angiostrongyliasis, Aliases & Descriptions:

Name: Angiostrongyliasis 9 41 11 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


External Ids:

Disease Ontology9 DOID:0050256
Orphanet47 74
MESH via Orphanet34 C536369
ICD10 via Orphanet26 B81.3, B83.2
UMLS via Orphanet61 C0392662
ICD1025 B83.2

Summaries for Angiostrongyliasis

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Disease Ontology:9 A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by angiostrongylus cantonensis or angiostrongylus costaricensis.

MalaCards based summary: Angiostrongyliasis is related to eosinophilia and meningitis. An important gene associated with Angiostrongyliasis is IL13 (interleukin 13), and among its related pathways are Selected targets of GCR alpha and Hematopoietic cell lineage. The compounds omalizumab and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and testes, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Wikipedia:63 Angiostrongyliasis is an infection by a nematode from the Angiostrongylus genus of kidney and alimentary... more...

Related Diseases for Angiostrongyliasis

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Diseases related to Angiostrongyliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia29.5CCL24, IL4, IL2, IL5, IL13
2meningitis10.5
3eosinophilic meningitis10.5
4kimura disease10.5IL5
5esophagitis, eosinophilic, 110.5IL5
6sinusitis10.4IL5
7leprosy10.4IL2
8periapical granuloma10.4IL4
9keratoconjunctivitis10.3IL5, IL13
10schistosomiasis10.3IL5, IL13
11parasitic helminthiasis infectious disease10.3IL5, IL13
12eosinophilic pneumonia10.3IL13, IL5
13filariasis10.3IL5, IL13
14neuritis10.3
15optic neuritis10.3
16esophagitis10.3IL13, IL5
17mastocytosis10.2IL5, IL13
18bronchiolitis10.2IL5, IL13
19egg allergy10.2IL4, IL5
20dermatitis10.2IL4, IL13
21intrinsic asthma10.2IL4, IL5
22allergic bronchopulmonary aspergillosis10.2IL4, IL5
23meningoencephalitis10.2
24omenn syndrome10.2IL4, IL5
25mycosis fungoides10.2IL5, IL2
26lepromatous leprosy10.2IL4, IL2
27agammaglobulinemia10.2IL4, IL2
28diphtheria10.1IL13, IL2
29acute graft versus host disease10.1IL2, IL4
30atopic dermatitis10.1IL4, IL13
31common variable immunodeficiency10.1IL2, IL4
32pulmonary tuberculosis10.1IL4, IL2
33lymphopenia10.1IL4, IL2
34myasthenia gravis10.1IL4, IL2
35bullous pemphigoid10.1IL5, IL13, PLAU
36conjunctivochalasis10.1MMP9, PLAU
37tropical spastic paraparesis10.1IL2, MMP9
38connective tissue disease10.0IL4, IL2
39abdominal aortic aneurysm10.0MMP9, PLAU
40allergic conjunctivitis10.0IL13, IL5, IL4
41ulcerative colitis10.0IL13, IL4, CCL24
42cutaneous leishmaniasis10.0IL13, IL5, IL4
43anisakiasis10.0
44meckel's diverticulum10.0
45appendicitis10.0
46pulmonary eosinophilia10.0IL4, IL5, IL13
47bone cancer10.0PLAU, MMP9
48allergic rhinitis10.0IL4, IL5, IL13
49food allergy10.0IL4, IL5, IL13
50leishmaniasis10.0IL13, IL5, IL4

Graphical network of the top 20 diseases related to Angiostrongyliasis:



Diseases related to angiostrongyliasis

Symptoms for Angiostrongyliasis

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Drugs & Therapeutics for Angiostrongyliasis

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Drug clinical trials:

Search ClinicalTrials for Angiostrongyliasis

Search NIH Clinical Center for Angiostrongyliasis

Genetic Tests for Angiostrongyliasis

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Anatomical Context for Angiostrongyliasis

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MalaCards organs/tissues related to Angiostrongyliasis:

31
Eye, Kidney, Testes, Colon, Liver, Lung, Skin

Animal Models for Angiostrongyliasis or affiliated genes

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MGI Mouse Phenotypes related to Angiostrongyliasis:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3PLAU, IL13, IL2, IL4
2MP:00020068.2MMP9, IL2, IL5, PLAU
3MP:00053708.2PLAU, IL5, IL2, IL4
4MP:00053817.5MMP9, IL4, IL2, IL5, IL13, PLAU
5MP:00053897.4MMP9, IL4, IL2, IL5, IL13, PLAU
6MP:00053787.4MMP9, IL4, IL2, IL5, IL13, PLAU
7MP:00053847.4MMP9, IL4, IL2, IL13, PLAU
8MP:00053767.3MMP9, IL4, IL2, IL5, IL13, PLAU
9MP:00053887.0PLAU, MMP9, CCL24, IL4, IL2, IL5
10MP:00053977.0MMP9, CCL24, IL4, IL2, IL5, IL13
11MP:00053876.9MMP9, CCL24, IL4, IL2, IL5, IL13

Publications for Angiostrongyliasis

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Articles related to Angiostrongyliasis:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Follow-up on anterior chamber angiostrongyliasis. (25124954)
2014
2
Angiostrongyliasis in Thailand: epidemiology and laboratory investigations. (23901379)
2013
3
Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis. (23390222)
2013
4
Workshop on research priorities for management and treatment of angiostrongyliasis(1). (23171634)
2012
5
Lung CT findings of angiostrongyliasis cantonensis caused by Angiostrongylus cantonensis. (21513853)
2011
6
An outbreak of angiostrongyliasis in Guanging, People's Republic of China: migrants vulnerable to an emerging disease. (22299428)
2011
7
Treatment of angiostrongyliasis using a combination of albendazole and dexamethasone: the results of a retrospective and comparative study. (21294950)
2011
8
Human ocular angiostrongyliasis: a literature review. (21296846)
2011
9
Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban patients with angiostrongyliasis. (21363978)
2011
10
Outcomes in mice with abdominal angiostrongyliasis treated with enoxaparin. (21400113)
2011
11
Application of recombinant SMR-domain containing protein of angiostrongylus cantonensis in immunoblot diagnosis of human angiostrongyliasis. (21073053)
2010
12
Abdominal angiostrongyliasis caused by Angiostrongylus cantonensis: a possible cause of eosinophilic infiltration in human digestive tract. (19545957)
2010
13
Human angiostrongyliasis outbreak in Dali, China. (19771154)
2009
14
Immunological diagnosis of human angiostrongyliasis due to Angiostrongylus cantonensis (Nematoda: Angiostrongylidae). (19117782)
2009
15
Individual serological follow-up of patients with suspected or confirmed abdominal angiostrongyliasis. (18327506)
2008
16
Abdominal angiostrongyliasis in rodent experimental infection: evidence for systemic circulation of first stage larvae. (17561438)
2007
17
Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. (17703945)
2007
18
Ocular angiostrongyliasis in a child--first case report from India. (16186138)
2006
19
Abdominal angiostrongyliasis: a case with severe evolution. (16553328)
2005
20
Ocular Angiostrongyliasis: removal of a live nematode from the anterior chamber. (15232595)
2005
21
Angiostrongyliasis, Mainland China. (16355510)
2005
22
Ocular parastrongyliasis (=angiostrongyliasis): probable first report of human infection from a patient in Ceylon (Sri Lanka). (15828436)
2004
23
Diagnosis of abdominal angiostrongyliasis by PCR from sera of patients. (14743672)
2003
24
First report of human angiostrongyliasis acquired in Sydney. (14558868)
2003
25
Evaluation of human IgG subclass antibodies in the serodiagnosis of angiostrongyliasis. (12658452)
2003
26
Ocular angiostrongyliasis without meningitis symptoms in Okinawa, Japan. (12053973)
2002
27
Angiostrongyliasis: analysis of antigens of Angiostrongylus costaricensis adult worms versus IgG from infected patients with Angiostrongylus cantonensis. (11414459)
2000
28
Jejunal perforation caused by abdominal angiostrongyliasis. (10602548)
1999
29
Seroepidemiology of abdominal angiostrongyliasis: the standardization of an immunoenzymatic assay and prevalence of antibodies in two localities in southern Brazil. (9491104)
1997
30
Detection of circulating antigen by monoclonal antibodies for immunodiagnosis of angiostrongyliasis. (9158049)
1997
31
Angiostrongyliasis in a European patient: a rare cause of gangrenous ischemic enterocolitis. (8224660)
1993
32
Human anisakiasis misdiagnosed as abdominal angiostrongyliasis. (8443320)
1993
33
Clinical studies on angiostrongyliasis cantonensis among children in Taiwan. (1822885)
1991
34
Clinical and epidemiological aspects of abdominal angiostrongyliasis in southern Brazil. (1844964)
1991
35
Immunodiagnosis of angiostrongyliasis with monoclonal antibodies recognizing a circulating antigen of mol. wt 91,000 from Angiostrongylus cantonensis. (1869351)
1991
36
Histopathological criteria for the diagnosis of abdominal angiostrongyliasis. (1792232)
1991
37
Serological investigations of a suspected case of human angiostrongyliasis. (3235133)
1988
38
Abdominal angiostrongyliasis: a problem of public health. (15275575)
1985
39
ELISA testing in cases of clinical angiostrongyliasis in Thailand. (4023800)
1985
40
Eosinophilic radiculomyeloencephalitis: an angiostrongyliasis outbreak in American Samoa related to ingestion of Achatina fulica snails. (7149098)
1982
41
Three cases of worm proven human angiostrongyliasis in Taiwan. (7343202)
1981
42
Angiostrongyliasis in Australia. (6930222)
1980
43
Clinical observations and immunodiagnosis of angiostrongyliasis in North Taiwan. (7219318)
1980
44
Angiostrongyliasis cantonensis. (287448)
1979
45
Pathological findings in four cases of human angiostrongyliasis. (725653)
1978
46
Angiostrongyliasis in Indonesia: additional geographic and host occurrence records. (751218)
1978
47
Ocular angiostrongyliasis in Semarang, Central Java. (842785)
1977
48
Case of ocular angiostrongyliasis associated with eosinophilic meningitis. (5102754)
1971
49
Eosinophilic meningoencephalitis caused by angiostrongyliasis in Thailand. Autopsy report. (4952148)
1967
50
Second case of ocular angiostrongyliasis in Thailand. (5901630)
1966

Variations for Angiostrongyliasis

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Expression for genes affiliated with Angiostrongyliasis

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Search GEO for disease gene expression data for Angiostrongyliasis.

Pathways for genes affiliated with Angiostrongyliasis

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Pathways related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL5, IL4
29.5IL4, IL5
39.4MMP9, PLAU
49.4PLAU, MMP9
59.4PLAU, MMP9
6
Show member pathways
Metalloproteases in connective tissue degradation
9.4PLAU, MMP9
79.4MMP9, PLAU
89.4PLAU, MMP9
99.4MMP9, PLAU
109.3IL13, IL2
11
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.2IL13, IL5, IL4
129.2IL13, IL5, IL4
13
Show member pathways
IL2 signaling events mediated by STAT536
9.1IL2, IL4
14
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.1IL2, IL4
15
Show member pathways
8.9MMP9, CCL24, PLAU
16
Show member pathways
8.9IL2, IL5, IL13
17
Show member pathways
8.9IL13, IL5, IL2
18
Show member pathways
8.8IL13, IL2, IL4
198.7IL4, IL2, IL5
20
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.7IL4, IL2, IL5
21
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.7IL4, IL2, IL5
228.5IL2, IL4, MMP9
238.3IL4, IL2, IL5, IL13
24
Show member pathways
Type III interferon signaling36
8.3IL4, IL2, IL5, IL13
258.3IL4, IL2, IL5, IL13
268.3IL13, IL5, IL2, IL4
278.3IL13, IL5, IL2, IL4
28
Show member pathways
8.3IL13, IL5, IL2, IL4
29
Show member pathways
8.3IL13, IL5, IL2, IL4
30
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
31
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
32
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
33
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
34
Show member pathways
7.8IL13, IL5, IL2, IL4, CCL24

Compounds for genes affiliated with Angiostrongyliasis

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Compounds related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1omalizumab43 1210.6IL13, IL4, IL5
2ovomucoid439.6IL4, IL5, IL13
3praziquantel43 1210.5IL5, IL4, IL13
4amphotericin b439.5IL4, IL5, IL13
5mip 1alpha439.5PLAU, IL13, IL4
6montelukast43 49 28 1212.5IL13, IL5, IL4
7budesonide43 49 1211.3IL5, IL13, IL4
8git 27599.2IL2, IL5, IL13
9rolipram43 59 2811.2IL5, IL4, IL13
104-ipp599.2IL5, IL13, IL2
11pirfenidone43 5910.2IL13, IL5, IL2
12as 10143 5910.2IL2, IL13, IL5
13alpha-galactosylceramide439.1IL4, IL2, IL13
14tdac439.1IL2, IL4
15c-d4t439.1IL4, IL5, IL2
16methacholine43 49 1211.1IL13, IL5, IL4
17erythromycin43 2 49 1212.1MMP9, IL5, IL13
18tarc439.1IL5, IL13, IL4, CCL24
19doxycycline43 1210.0IL5, IL13, PLAU, MMP9
20fluticasone propionate43 49 59 1212.0IL4, IL5, IL13, MMP9
21con a438.9IL4, IL2, IL5
22bleomycin43 129.9IL4, MMP9, IL5, IL13
23polyinosinic-polycytidylic acid438.8IL5, IL2, IL4
24glatiramer acetate43 129.8IL5, IL2, IL13, IL4
25salmeterol43 49 28 1211.8IL13, IL4, IL5, IL2
26il-12438.8IL2, IL5, IL13, IL4
27gm-csf43 289.8IL13, IL4, IL5, IL2
28il 10438.8IL13, IL4, IL2, IL5
29ionomycin438.6IL2, IL5, IL13, IL4
30ivig438.6IL4, IL5, MMP9
31tacrolimus43 49 1210.6IL2, IL4, IL5, IL13
32thapsigargin43 599.6IL4, IL13, PLAU, IL2
33calcitriol43 59 24 1211.5IL2, PLAU, IL4, IL13
34sb 20358043 599.5IL13, IL4, IL5, MMP9, PLAU
35ly294002438.5IL4, IL5, IL13, PLAU, MMP9
36cyclophosphamide43 49 1210.4MMP9, IL4, IL2, IL13
37adenylate438.4IL4, PLAU, IL13, IL5, MMP9
38hydrocortisone43 2 59 1211.3IL4, IL2, PLAU, IL5, IL13
39indomethacin43 28 59 1211.3IL5, PLAU, IL13, IL2, IL4
40thymidine43 249.2IL2, PLAU, IL13, IL4, IL5
41cyclosporin a43 28 5910.1MMP9, IL4, IL2, IL13, IL5
42herbimycin a43 599.1MMP9, IL5, IL2, IL4, PLAU
43dexamethasone43 49 28 1210.9IL13, IL5, MMP9, IL2, IL4
44histamine43 28 249.8IL2, CCL24, IL4, IL5, IL13, PLAU
45pge2437.7MMP9, IL2, IL5, PLAU, IL13, IL4
46cycloheximide437.7MMP9, IL2, PLAU, IL13, IL5, IL4
47vegf437.7IL13, PLAU, IL2, IL4, MMP9, IL5
48rantes437.7IL5, IL2, IL4, CCL24, MMP9, IL13
49actinomycin d437.6IL2, IL4, MMP9, PLAU, CCL24, IL13
50tyrosine437.4MMP9, IL4, IL2, IL5, IL13, PLAU

GO Terms for genes affiliated with Angiostrongyliasis

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Cellular components related to Angiostrongyliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.8PLAU, IL13, IL5, IL2, MMP9
2extracellular spaceGO:00056156.4PLAU, MMP9, CCL24, IL4, IL2, IL5

Biological processes related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:00101559.8IL4, IL13
2positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL5, IL4
3positive regulation of immunoglobulin secretionGO:00510249.5IL5, IL2
4positive regulation of isotype switching to IgG isotypesGO:00483049.4IL2, IL4
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.3IL4, IL2
6response to ethanolGO:00454719.3IL13, IL4
7positive regulation of activated T cell proliferationGO:00421049.3IL2, IL4
8inflammatory responseGO:00069549.2CCL24, IL5, IL13
9chemotaxisGO:00069359.2PLAU, IL4, CCL24
10extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.1IL2, IL4
11positive regulation of inflammatory responseGO:00507299.0IL2, CCL24
12cell-cell signalingGO:00072678.9IL13, IL2, CCL24
13positive regulation of B cell proliferationGO:00308908.6IL13, IL5, IL2, IL4
14immune responseGO:00069558.1CCL24, IL4, IL2, IL5, IL13

Molecular functions related to Angiostrongyliasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080838.7IL5, IL2, IL4
2cytokine activityGO:00051258.0IL13, IL5, IL2, IL4

Products for genes affiliated with Angiostrongyliasis

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  • Antibodies
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Sources for Angiostrongyliasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet