MCID: ANG002
MIFTS: 52

Angiostrongyliasis malady

Rare diseases, Infectious diseases categories
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Summaries for Angiostrongyliasis

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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by angiostrongylus cantonensis or angiostrongylus costaricensis.

MalaCards based summary: Angiostrongyliasis is related to eosinophilia and eosinophilic meningitis. An important gene associated with Angiostrongyliasis is IL13 (interleukin 13), and among its related pathways are Selected targets of GCR alpha and Hematopoietic cell lineage. The compounds omalizumab and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and testes, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Wikipedia:65 Angiostrongyliasis is an infection by a nematode from the Angiostrongylus genus of kidney and alimentary... more...

Aliases & Classifications for Angiostrongyliasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Angiostrongyliasis, Aliases & Descriptions:

Name: Angiostrongyliasis 8 42 10 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


External Ids:

Disease Ontology8 DOID:0050256
MESH via Orphanet35 C536369
ICD10 via Orphanet26 B81.3, B83.2
UMLS via Orphanet63 C0392662
ICD1025 B83.2

Related Diseases for Angiostrongyliasis

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Diseases related to Angiostrongyliasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia29.5IL2, IL4, CCL24, IL5, IL13
2eosinophilic meningitis10.5
3meningitis10.5
4kimura disease10.5IL5
5eosinophilic esophagitis10.5IL5
6sinusitis10.4IL5
7leprosy10.4IL2
8periapical granuloma10.4IL4
9keratoconjunctivitis10.3IL5, IL13
10helminthiasis10.3IL5, IL13
11eosinophilic pneumonia10.3IL5, IL13
12filariasis10.3IL13, IL5
13neuritis10.3
14optic neuritis10.3
15esophagitis10.3IL13, IL5
16mastocytosis10.3IL13, IL5
17bronchiolitis10.3IL5, IL13
18egg allergy10.2IL4, IL5
19intrinsic asthma10.2IL5, IL4
20allergic bronchopulmonary aspergillosis10.2IL5, IL4
21omenn syndrome10.2IL4, IL5
22meningoencephalitis10.2
23mycosis fungoides10.2IL2, IL5
24lepromatous leprosy10.2IL2, IL4
25bruton-type agammaglobulinemia10.2IL4, IL2
26diphtheria10.2IL2, IL13
27acute graft versus host disease10.1IL2, IL4
28atopic dermatitis10.1IL13, IL4
29common variable immunodeficiency10.1IL4, IL2
30pulmonary tuberculosis10.1IL4, IL2
31lymphopenia10.1IL4, IL2
32myasthenia gravis10.1IL2, IL4
33bullous pemphigoid10.1IL13, IL5, PLAU
34conjunctivochalasis10.1MMP9, PLAU
35tropical spastic paraparesis10.1MMP9, IL2
36connective tissue disease10.1IL4, IL2
37abdominal aortic aneurysm10.0PLAU, MMP9
38allergic conjunctivitis10.0IL13, IL5, IL4
39ulcerative colitis10.0CCL24, IL13, IL4
40cutaneous leishmaniasis10.0IL5, IL4, IL13
41bone cancer10.0PLAU, MMP9
42pulmonary eosinophilia10.0IL4, IL5, IL13
43allergic rhinitis10.0IL13, IL5, IL4
44food allergy10.0IL4, IL5, IL13
45leishmaniasis10.0IL4, IL5, IL13
46schistosomiasis10.0IL13, IL5, IL4
47skin disease10.0IL2, MMP9
48anisakiasis10.0
49meckel's diverticulum10.0
50appendicitis10.0

Graphical network of the top 20 diseases related to Angiostrongyliasis:



Diseases related to angiostrongyliasis

Symptoms for Angiostrongyliasis

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Drugs & Therapeutics for Angiostrongyliasis

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Drug clinical trials:

Search ClinicalTrials for Angiostrongyliasis

Search NIH Clinical Center for Angiostrongyliasis

Genetic Tests for Angiostrongyliasis

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Anatomical Context for Angiostrongyliasis

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MalaCards organs/tissues related to Angiostrongyliasis:

32
Eye, Kidney, Testes, Colon, Liver, Lung, Skin

Animal Models for Angiostrongyliasis or affiliated genes

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MGI Mouse Phenotypes related to Angiostrongyliasis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3PLAU, IL13, IL2, IL4
2MP:00020068.2MMP9, IL2, IL5, PLAU
3MP:00053708.2PLAU, IL5, IL2, IL4
4MP:00053817.5MMP9, IL4, IL2, IL5, IL13, PLAU
5MP:00053897.4MMP9, IL4, IL2, IL5, IL13, PLAU
6MP:00053787.4MMP9, IL4, IL2, IL5, IL13, PLAU
7MP:00053847.4MMP9, IL4, IL2, IL13, PLAU
8MP:00053767.3MMP9, IL4, IL2, IL5, IL13, PLAU
9MP:00053887.0PLAU, MMP9, CCL24, IL4, IL2, IL5
10MP:00053977.0MMP9, CCL24, IL4, IL2, IL5, IL13
11MP:00053876.9MMP9, CCL24, IL4, IL2, IL5, IL13

Publications for Angiostrongyliasis

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Articles related to Angiostrongyliasis:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Follow-up on anterior chamber angiostrongyliasis. (25124954)
2014
2
Angiostrongyliasis in Thailand: epidemiology and laboratory investigations. (23901379)
2013
3
Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis. (23390222)
2013
4
Anterior chamber angiostrongyliasis. (23846206)
2013
5
Workshop on research priorities for management and treatment of angiostrongyliasis(1). (23171634)
2012
6
Lung CT findings of angiostrongyliasis cantonensis caused by Angiostrongylus cantonensis. (21513853)
2011
7
An outbreak of angiostrongyliasis in Guanging, People's Republic of China: migrants vulnerable to an emerging disease. (22299428)
2011
8
Treatment of angiostrongyliasis using a combination of albendazole and dexamethasone: the results of a retrospective and comparative study. (21294950)
2011
9
Human ocular angiostrongyliasis: a literature review. (21296846)
2011
10
Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban patients with angiostrongyliasis. (21363978)
2011
11
Outcomes in mice with abdominal angiostrongyliasis treated with enoxaparin. (21400113)
2011
12
Application of recombinant SMR-domain containing protein of angiostrongylus cantonensis in immunoblot diagnosis of human angiostrongyliasis. (21073053)
2010
13
Abdominal angiostrongyliasis caused by Angiostrongylus cantonensis: a possible cause of eosinophilic infiltration in human digestive tract. (19545957)
2010
14
Human angiostrongyliasis outbreak in Dali, China. (19771154)
2009
15
Immunological diagnosis of human angiostrongyliasis due to Angiostrongylus cantonensis (Nematoda: Angiostrongylidae). (19117782)
2009
16
Individual serological follow-up of patients with suspected or confirmed abdominal angiostrongyliasis. (18327506)
2008
17
Abdominal angiostrongyliasis in rodent experimental infection: evidence for systemic circulation of first stage larvae. (17561438)
2007
18
Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. (17703945)
2007
19
Ocular angiostrongyliasis in a child--first case report from India. (16186138)
2006
20
Abdominal angiostrongyliasis: a case with severe evolution. (16553328)
2005
21
Ocular Angiostrongyliasis: removal of a live nematode from the anterior chamber. (15232595)
2005
22
Angiostrongyliasis, Mainland China. (16355510)
2005
23
Ocular parastrongyliasis (=angiostrongyliasis): probable first report of human infection from a patient in Ceylon (Sri Lanka). (15828436)
2004
24
Diagnosis of abdominal angiostrongyliasis by PCR from sera of patients. (14743672)
2003
25
First report of human angiostrongyliasis acquired in Sydney. (14558868)
2003
26
Evaluation of human IgG subclass antibodies in the serodiagnosis of angiostrongyliasis. (12658452)
2003
27
Angiostrongyliasis: analysis of antigens of Angiostrongylus costaricensis adult worms versus IgG from infected patients with Angiostrongylus cantonensis. (11414459)
2000
28
Jejunal perforation caused by abdominal angiostrongyliasis. (10602548)
1999
29
Seroepidemiology of abdominal angiostrongyliasis: the standardization of an immunoenzymatic assay and prevalence of antibodies in two localities in southern Brazil. (9491104)
1997
30
Detection of circulating antigen by monoclonal antibodies for immunodiagnosis of angiostrongyliasis. (9158049)
1997
31
Angiostrongyliasis in a European patient: a rare cause of gangrenous ischemic enterocolitis. (8224660)
1993
32
Human anisakiasis misdiagnosed as abdominal angiostrongyliasis. (8443320)
1993
33
Clinical studies on angiostrongyliasis cantonensis among children in Taiwan. (1822885)
1991
34
Clinical and epidemiological aspects of abdominal angiostrongyliasis in southern Brazil. (1844964)
1991
35
Immunodiagnosis of angiostrongyliasis with monoclonal antibodies recognizing a circulating antigen of mol. wt 91,000 from Angiostrongylus cantonensis. (1869351)
1991
36
Histopathological criteria for the diagnosis of abdominal angiostrongyliasis. (1792232)
1991
37
Serological investigations of a suspected case of human angiostrongyliasis. (3235133)
1988
38
Abdominal angiostrongyliasis: a problem of public health. (15275575)
1985
39
ELISA testing in cases of clinical angiostrongyliasis in Thailand. (4023800)
1985
40
Eosinophilic radiculomyeloencephalitis: an angiostrongyliasis outbreak in American Samoa related to ingestion of Achatina fulica snails. (7149098)
1982
41
Three cases of worm proven human angiostrongyliasis in Taiwan. (7343202)
1981
42
Angiostrongyliasis in Australia. (6930222)
1980
43
Clinical observations and immunodiagnosis of angiostrongyliasis in North Taiwan. (7219318)
1980
44
Angiostrongyliasis cantonensis. (287448)
1979
45
Pathological findings in four cases of human angiostrongyliasis. (725653)
1978
46
Angiostrongyliasis in Indonesia: additional geographic and host occurrence records. (751218)
1978
47
Ocular angiostrongyliasis in Semarang, Central Java. (842785)
1977
48
Case of ocular angiostrongyliasis associated with eosinophilic meningitis. (5102754)
1971
49
Eosinophilic meningoencephalitis caused by angiostrongyliasis in Thailand. Autopsy report. (4952148)
1967
50
Second case of ocular angiostrongyliasis in Thailand. (5901630)
1966

Variations for Angiostrongyliasis

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Expression for genes affiliated with Angiostrongyliasis

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Expression patterns in normal tissues for genes affiliated with Angiostrongyliasis

Search GEO for disease gene expression data for Angiostrongyliasis.

Pathways for genes affiliated with Angiostrongyliasis

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Pathways related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL4, IL5
29.5IL5, IL4
39.5IL4, IL5
49.4MMP9, PLAU
59.4PLAU, MMP9
69.4PLAU, MMP9
7
Show member pathways
9.4PLAU, MMP9
89.4MMP9, PLAU
99.4PLAU, MMP9
109.4MMP9, PLAU
119.3IL13, IL2
12
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.2IL13, IL5, IL4
139.2IL13, IL5, IL4
14
Show member pathways
IL2 signaling events mediated by STAT537
9.1IL2, IL4
15
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1IL2, IL4
16
Show member pathways
8.9MMP9, CCL24, PLAU
17
Show member pathways
8.9IL2, IL5, IL13
18
Show member pathways
8.9IL13, IL5, IL2
19
Show member pathways
8.8IL13, IL2, IL4
208.7IL4, IL2, IL5
21
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.7IL4, IL2, IL5
22
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.7IL4, IL2, IL5
238.5IL2, IL4, MMP9
248.3IL4, IL2, IL5, IL13
25
Show member pathways
Type III interferon signaling37
8.3IL4, IL2, IL5, IL13
268.3IL4, IL2, IL5, IL13
278.3IL13, IL5, IL2, IL4
288.3IL13, IL5, IL2, IL4
29
Show member pathways
8.3IL13, IL5, IL2, IL4
30
Show member pathways
8.3IL13, IL5, IL2, IL4
31
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
32
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
33
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
34
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
35
Show member pathways
7.8IL13, IL5, IL2, IL4, CCL24

Compounds for genes affiliated with Angiostrongyliasis

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Compounds related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1omalizumab44 1110.6IL13, IL4, IL5
2ovomucoid449.6IL4, IL5, IL13
3praziquantel44 1110.5IL5, IL4, IL13
4amphotericin b449.5IL4, IL5, IL13
5mip 1alpha449.5PLAU, IL13, IL4
6montelukast44 50 28 1112.5IL13, IL5, IL4
7budesonide44 50 1111.3IL5, IL13, IL4
8git 27619.2IL2, IL5, IL13
9rolipram44 61 2811.2IL5, IL4, IL13
104-ipp619.2IL5, IL13, IL2
11pirfenidone44 6110.2IL13, IL5, IL2
12as 10144 6110.2IL2, IL13, IL5
13alpha-galactosylceramide449.1IL4, IL2, IL13
14tdac449.1IL2, IL4
15c-d4t449.1IL4, IL5, IL2
16methacholine44 50 1111.1IL13, IL5, IL4
17erythromycin44 2 50 1112.1MMP9, IL5, IL13
18tarc449.1IL5, IL13, IL4, CCL24
19doxycycline44 1110.0IL5, IL13, PLAU, MMP9
20fluticasone propionate44 50 61 1112.0IL4, IL5, IL13, MMP9
21con a448.9IL4, IL2, IL5
22bleomycin44 119.9IL4, MMP9, IL5, IL13
23polyinosinic-polycytidylic acid448.8IL5, IL2, IL4
24glatiramer acetate44 119.8IL5, IL2, IL13, IL4
25salmeterol44 50 28 1111.8IL13, IL4, IL5, IL2
26il-12448.8IL2, IL5, IL13, IL4
27gm-csf44 289.8IL13, IL4, IL5, IL2
28il 10448.8IL13, IL4, IL2, IL5
29ionomycin448.6IL2, IL5, IL13, IL4
30ivig448.6IL4, IL5, MMP9
31tacrolimus44 50 1110.6IL2, IL4, IL5, IL13
32thapsigargin44 619.6IL4, IL13, PLAU, IL2
33calcitriol44 61 24 1111.5IL2, PLAU, IL4, IL13
34sb 20358044 619.5IL13, IL4, IL5, MMP9, PLAU
35ly294002448.5IL4, IL5, IL13, PLAU, MMP9
36cyclophosphamide44 50 1110.4MMP9, IL4, IL2, IL13
37adenylate448.4IL4, PLAU, IL13, IL5, MMP9
38hydrocortisone44 2 61 1111.3IL4, IL2, PLAU, IL5, IL13
39indomethacin44 28 61 1111.3IL5, PLAU, IL13, IL2, IL4
40thymidine44 249.2IL2, PLAU, IL13, IL4, IL5
41cyclosporin a44 28 6110.1MMP9, IL4, IL2, IL13, IL5
42herbimycin a44 619.1MMP9, IL5, IL2, IL4, PLAU
43dexamethasone44 50 28 1110.9IL13, IL5, MMP9, IL2, IL4
44histamine44 28 249.8IL2, CCL24, IL4, IL5, IL13, PLAU
45pge2447.7MMP9, IL2, IL5, PLAU, IL13, IL4
46cycloheximide447.7MMP9, IL2, PLAU, IL13, IL5, IL4
47vegf447.7IL13, PLAU, IL2, IL4, MMP9, IL5
48rantes447.7IL5, IL2, IL4, CCL24, MMP9, IL13
49actinomycin d447.6IL2, IL4, MMP9, PLAU, CCL24, IL13
50tyrosine447.4MMP9, IL4, IL2, IL5, IL13, PLAU

GO Terms for genes affiliated with Angiostrongyliasis

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Cellular components related to Angiostrongyliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8PLAU, IL13, IL5, IL2, MMP9
2extracellular spaceGO:0056156.4PLAU, MMP9, CCL24, IL4, IL2, IL5

Biological processes related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:0101559.8IL4, IL13
2positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5IL5, IL4
3positive regulation of immunoglobulin secretionGO:0510249.5IL5, IL2
4positive regulation of isotype switching to IgG isotypesGO:0483049.4IL2, IL4
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.3IL4, IL2
6response to ethanolGO:0454719.3IL13, IL4
7positive regulation of activated T cell proliferationGO:0421049.3IL2, IL4
8inflammatory responseGO:0069549.2CCL24, IL5, IL13
9chemotaxisGO:0069359.2PLAU, IL4, CCL24
10extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.1IL2, IL4
11positive regulation of inflammatory responseGO:0507299.0IL2, CCL24
12cell-cell signalingGO:0072678.9IL13, IL2, CCL24
13positive regulation of B cell proliferationGO:0308908.6IL13, IL5, IL2, IL4
14immune responseGO:0069558.1CCL24, IL4, IL2, IL5, IL13

Molecular functions related to Angiostrongyliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.7IL5, IL2, IL4
2cytokine activityGO:0051258.0IL13, IL5, IL2, IL4

Products for genes affiliated with Angiostrongyliasis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Angiostrongyliasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet