MCID: ANG002
MIFTS: 50

Angiostrongyliasis malady

Infectious diseases category

Summaries for Angiostrongyliasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by angiostrongylus cantonensis or angiostrongylus costaricensis.

MalaCards: Angiostrongyliasis is related to meningitis and eosinophilia. An important gene associated with Angiostrongyliasis is SNAI2 (snail family zinc finger 2), and among its related pathways are Leishmaniasis and IL12 signaling mediated by STAT4. The compounds amphotericin b and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and testes, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Wikipedia:63 Angiostrongyliasis is an infection by a nematode from the Angiostrongylus genus of kidney and alimentary... more...

Aliases & Classifications for Angiostrongyliasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

angiostrongyliasis 8 42 10 48 60


External Ids:

Disease Ontology8 DOID:0050256
MESH via Orphanet35 C536369
ICD10 via Orphanet26 B81.3, B83.2
SNOMED-CT via Orphanet57 61750000
UMLS via Orphanet61 C0392662
ICD1025 B83.2

Related Diseases for Angiostrongyliasis

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17GeneCards, 18GeneDecks
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Diseases related to Angiostrongyliasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis30.7MMP9
2eosinophilia29.9IL2, IL4, IL5, IL13, CCL24
3eosinophilic meningitis10.5
4meningoencephalitis10.1
5neuritis10.1
6optic neuritis10.1
7gnathomiasis10.0ANGPTL6
8sinusitis10.0IL5
9churg-strauss syndrome10.0IL5
10malignant mesothelioma10.0SNAI2
11kimura disease10.0IL5
12eosinophilic esophagitis10.0IL5
13onchocerciasis10.0IL5
14hypereosinophilic syndrome10.0IL5
15pemphigus vulgaris10.0PLAU
16pemphigus10.0PLAU
17endometriosis10.0PLAU
18interstitial lung disease10.0MMP9
19pulmonary disease, chronic obstructive10.0MMP9
20dermatitis herpetiformis10.0PLAU
21laryngeal benign neoplasm10.0PLAU
22diabetes mellitus10.0MMP9
23periodontitis10.0MMP9
24paragonimiasis10.0IL5
25uveitis10.0IL4
26inflammatory bowel disease10.0IL2
27keratoconjunctivitis10.0IL13, IL5
28hepatitis b10.0IL2
29bronchiolitis10.0IL13, IL5
30filariasis10.0IL13, IL5
31esophagitis10.0IL5, IL13
32pneumonia10.0IL5, IL13
33leprosy10.0IL2
34periapical granuloma10.0IL4
35toxic shock syndrome10.0IL2
36diarrhea10.0IL2
37sarcoma10.0IL2
38helminthiasis10.0IL5, IL13
39kawasaki disease10.0MMP9
40osteoarthritis10.0PLAU, MMP9
41eosinophilic pneumonia10.0IL5, IL13
42adenocarcinoma10.0PLAU, MMP9
43atherosclerosis10.0MMP9, PLAU
44graves' disease10.0IL4, IL13
45egg allergy10.0IL5, IL4
46colon cancer10.0PLAU, MMP9
47allergic bronchopulmonary aspergillosis10.0IL5, IL4
48oral cancer10.0PLAU, MMP9
49prostate cancer10.0PLAU, MMP9
50intrinsic asthma10.0IL5, IL4

Graphical network of the top 20 diseases related to Angiostrongyliasis:



Diseases related to angiostrongyliasis

Clinical Features for Angiostrongyliasis

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Drugs & Therapeutics for Angiostrongyliasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Angiostrongyliasis

Drug clinical trials:

Search ClinicalTrials for Angiostrongyliasis

Search NIH Clinical Center for Angiostrongyliasis

Search CenterWatch for Angiostrongyliasis

Genetic Tests for Angiostrongyliasis

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Anatomical Context for Angiostrongyliasis

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32MalaCards
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MalaCards organs/tissues related to Angiostrongyliasis:

32
Eye, Kidney, Testes, Colon, Liver, Lung, Skin

Animal Models for Angiostrongyliasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Angiostrongyliasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.3IL13, MMP9, PLAU
2MP:00053799.3IL2, IL4
3MP:00053889.3PLAU, MMP9, CCL24
4MP:00053817.9SNAI2, IL13, IL5, IL4, IL2, MMP9
5MP:00107687.5ANGPTL6, IL13, IL4, IL2, MMP9, PLAU
6MP:00053977.4CCL24, SNAI2, IL13, IL5, IL4, IL2
7MP:00053877.3CCL24, SNAI2, IL13, IL5, IL4, IL2
8MP:00053767.3ANGPTL6, IL13, IL5, IL4, IL2, MMP9
9MP:00053787.1SNAI2, ANGPTL6, IL13, IL5, IL4, IL2

Publications for Angiostrongyliasis

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Sources:
50PubMed
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Articles related to Angiostrongyliasis:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Angiostrongyliasis in Thailand: epidemiology and laboratory investigations. (23901379)
2013
2
Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis. (23390222)
2013
3
The role of eosinophils in angiostrongyliasis: multiple roles for a versatile cell? (23901384)
2013
4
A comparative study of neuroimaging features between human neuro-gnathostomiasis and angiostrongyliasis. (22124854)
2012
5
Treatment of angiostrongyliasis using a combination of albendazole and dexamethasone: the results of a retrospective and comparative study. (21294950)
2011
6
Outcomes in mice with abdominal angiostrongyliasis treated with enoxaparin. (21400113)
2011
7
An indirect immunofluorescence antibody test employing whole eggs as the antigen for the diagnosis of abdominal angiostrongyliasis. (21739024)
2011
8
International symposium on Angiostrongylus and Angiostrongyliasis, 2010. (21762566)
2011
9
Abdominal angiostrongyliasis with involvement of liver histopathologically confirmed: a case report. (21915466)
2011
10
Application of recombinant SMR-domain containing protein of angiostrongylus cantonensis in immunoblot diagnosis of human angiostrongyliasis. (21073053)
2010
11
Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. (20584616)
2010
12
Use of heterologous antigens for the immunodiagnosis of abdominal angiostrongyliasis by an enzyme-linked immunosorbent assay. (21120363)
2010
13
Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals. (21120370)
2010
14
Human angiostrongyliasis outbreak in Dali, China. (19771154)
2009
15
Immunological diagnosis of human angiostrongyliasis due to Angiostrongylus cantonensis (Nematoda: Angiostrongylidae). (19117782)
2009
16
Ocular angiostrongyliasis: clinical study of three cases. (18535614)
2008
17
Optic neuritis caused by intraocular angiostrongyliasis. (19062688)
2008
18
Angiostrongylus costaricensis egg antigen for the immunodiagnosis of abdominal angiostrongyliasis. (18462556)
2008
19
Treatment of angiostrongyliasis. (18501934)
2008
20
Abdominal angiostrongyliasis in rodent experimental infection: evidence for systemic circulation of first stage larvae. (17561438)
2007
21
Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. (17703945)
2007
22
Intraocular angiostrongyliasis: clinical findings, treatments and outcomes. (17064748)
2007
23
Ocular angiostrongyliasis in a child--first case report from India. (16186138)
2006
24
Chemo-paralysis for the removal of a live intraocular worm in ocular angiostrongyliasis. (16872350)
2006
25
Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis. (16623755)
2006
26
Evaluation of human IgG subclass antibodies in the serodiagnosis of angiostrongyliasis. (12658452)
2003
27
A clinical study of eosinophilic meningoencephalitis caused by angiostrongyliasis. (12411101)
2002
28
Specific IgG antibody subclasses to Angiostrongylus cantonensis in patients with angiostrongyliasis. (12744624)
2002
29
Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay. (11391424)
2001
30
Genetic analysis of mortality in murine angiostrongyliasis costaricensis using SMXA recombinant inbred mouse strains. (11077268)
2000
31
Neuro-angiostrongyliasis: unresolved issues. (11113256)
2000
32
Cerebrospinal angiostrongyliasis in five captive tamarins (Sanguinus spp). (9578750)
1998
33
Clinical studies on angiostrongyliasis cantonensis among children in Taiwan. (1822885)
1991
34
Clinical and epidemiological aspects of abdominal angiostrongyliasis in southern Brazil. (1844964)
1991
35
Snail borne parasitic zoonoses: angiostrongyliasis. (1822884)
1991
36
Abdominal angiostrongyliasis in Nicaragua: a clinico-pathological study on a series of 12 cases reports. (1822656)
1991
37
Historical summary of angiostrongyliasis cantonensis as a new parasitic disease of man. (3064944)
1988
38
First report of human angiostrongyliasis in Hong Kong diagnosed by computerized axial topography (CAT) and enzyme linked immunosorbent assay. (6464132)
1984
39
Studies on suspected clinical and experimental angiostrongyliasis: serological responses. (6443362)
1984
40
Eosinophilic radiculomyeloencephalitis: an angiostrongyliasis outbreak in American Samoa related to ingestion of Achatina fulica snails. (7149098)
1982
41
Three cases of worm proven human angiostrongyliasis in Taiwan. (7343202)
1981
42
Clinical observations and immunodiagnosis of angiostrongyliasis in North Taiwan. (7219318)
1980
43
Angiostrongyliasis cantonensis. (287448)
1979
44
Pathological findings in four cases of human angiostrongyliasis. (725653)
1978
45
Clinical manifestations and laboratory diagnosis of eosinophilic meningitis syndrome associated with angiostrongyliasis. (725650)
1978
46
Ocular angiostrongyliasis in Semarang, Central Java. (842785)
1977
47
Studies on immunodiagnosis of angiostrongyliasis. 5. Double immunodiffusion and counterelectrophoresis for detection of antibody in infected rat and human sera. (4218158)
1974
48
Studies on immunodiagnosis of angiostrongyliasis. 1. Detection of antigen and antibody in serum and cerebrospinal fluid. (4634134)
1973
49
Second case of ocular angiostrongyliasis in Thailand. (5901630)
1966
50
Human angiostrongyliasis of the eye in Bangkok. (13986349)
1962

Genetic Variations for Angiostrongyliasis

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Expression for genes affiliated with Angiostrongyliasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiostrongyliasis

Search GEO for disease gene expression data for Angiostrongyliasis.

Pathways for genes affiliated with Angiostrongyliasis

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Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems, 59Tocris Bioscience, 12EMD Millipore
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Pathways related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8IL5, IL13
29.7IL2, IL13
39.6PLAU, MMP9
49.6PLAU, MMP9
59.6PLAU, MMP9
6
Hide members
9.4IL4, IL5, IL13
79.4IL13, IL5, IL4
8
Hide members
9.4IL2, IL5, IL13
9
Hide members
9.4IL13, IL5, IL2
10
Hide members
9.3IL5, IL4, IL2
11
Hide members
9.3IL2, IL4, IL5
129.3IL2, IL4, IL5
139.2IL4, IL2, MMP9
14
Hide members
9.0ANGPTL6, MMP9, PLAU
158.9IL2, IL4, IL5, IL13
168.9IL2, IL4, IL5, IL13
178.9IL13, IL5, IL4, IL2
188.9IL13, IL5, IL4, IL2
19
Hide members
8.9IL13, IL5, IL4, IL2
20
Hide members
8.7IL5, ANGPTL6, SNAI2, CCL24
21
Hide members
8.4CCL24, IL13, IL5, IL4, IL2
22
Hide members
8.2CCL24, ANGPTL6, IL13, IL5, IL2
23
Hide members
7.8CCL24, ANGPTL6, IL13, IL5, IL4, IL2
24
Hide members
7.5CCL24, SNAI2, ANGPTL6, IL13, IL5, IL4

Compounds for genes affiliated with Angiostrongyliasis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1amphotericin b4410.5IL13
2hydrocortisone44 2 59 1113.4PLAU
3cyclophosphamide44 49 1112.4IL2
4erythromycin44 49 2 1113.1MMP9
5rantes4410.1IL2, IL4
6oxazolone449.9IL13, IL4
7loteprednol44 1110.9IL4, IL5
8tdac449.9IL2, IL4
9thapsigargin44 5910.9IL13, PLAU
10tolnaftate449.9IL4, IL5
11mometasone44 1110.8IL5, IL4
12omalizumab44 1110.8IL4, IL5, IL13
13praziquantel44 1110.8IL5, IL13, IL4
14montelukast44 49 28 1112.8IL13, IL5, IL4
15git 27599.7IL2, IL5, IL13
164-ipp599.7IL2, IL5, IL13
17as 10159 4410.7IL13, IL2, IL5
18alpha-galactosylceramide449.7IL2, IL4, IL13
19budesonide44 49 1111.7IL5, IL13, IL4
20c-d4t449.7IL2, IL4, IL5
21mip 1alpha449.6PLAU, IL4, IL13
22con a449.6IL4, IL2, IL5
23pge2449.6PLAU, MMP9, IL2
24methacholine44 1110.5IL4, IL13, IL5
25polyinosinic-polycytidylic acid449.5IL2, IL5, IL4
26fluticasone propionate44 49 59 1112.5MMP9, IL13, IL5, IL4
27bleomycin44 1110.4MMP9, IL5, IL13, IL4
28glatiramer acetate44 1110.4IL13, IL5, IL4, IL2
29salmeterol44 49 28 1112.4IL5, IL2, IL4, IL13
30il-12449.4IL5, IL4, IL13, IL2
31il 10449.4IL13, IL2, IL4, IL5
32doxycycline44 1110.3PLAU, MMP9, IL5, IL13
33ribavirin44 49 1111.3IL2, IL4, MMP9
34tarc449.3CCL24, IL13, IL5, IL4
35ionomycin449.3IL5, IL13, IL2, IL4
36tacrolimus44 49 1111.2IL4, IL2, IL5, IL13
37pentoxifylline44 1110.2IL4, IL13, IL2
38calcitriol44 59 11 2412.0IL2, PLAU, IL4, IL13
39ccl344 2810.0CCL24, IL13, MMP9
40sb 20358044 599.9PLAU, MMP9, IL5, IL13, IL4
41ly294002448.9MMP9, IL13, IL5, IL4, PLAU
42indomethacin44 59 28 1111.8PLAU, IL4, IL5, IL13, IL2
43herbimycin a44 599.8IL4, IL2, PLAU, MMP9, IL5
44adenylate448.8PLAU, IL5, IL13, IL4, MMP9
45thymidine44 249.8IL2, IL5, IL4, PLAU, IL13
46dexamethasone44 49 28 1111.6IL2, MMP9, IL4, IL5, IL13
47vegf448.4MMP9, IL4, IL5, IL2, IL13, PLAU
48histamine44 28 2410.3CCL24, IL5, IL13, PLAU, IL2, IL4
49actinomycin d448.3IL13, MMP9, IL2, IL4, CCL24, PLAU
50tyrosine448.1SNAI2, IL13, IL5, PLAU, IL4, IL2

GO Terms for genes affiliated with Angiostrongyliasis

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16Gene Ontology
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Cellular components related to Angiostrongyliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8PLAU, MMP9, IL2, IL5, IL13, ANGPTL6
2extracellular spaceGO:0056157.2PLAU, CCL24, IL13, IL5, IL4, IL2

Biological processes related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:0101559.9IL4, IL13
2positive regulation of immunoglobulin secretionGO:0510249.7IL2, IL5
3positive regulation of isotype switching to IgG isotypesGO:0483049.7IL4, IL2
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.5IL4, IL2
5positive regulation of activated T cell proliferationGO:0421049.3IL2, IL4
6cell-cell signalingGO:0072679.2IL2, IL13, CCL24
7positive regulation of B cell proliferationGO:0308909.1IL2, IL4, IL5, IL13
8chemotaxisGO:0069359.0PLAU, IL4, CCL24
9immune responseGO:0069558.6CCL24, IL13, IL5, IL4, IL2

Molecular functions related to Angiostrongyliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3IL2, IL4, IL5
2cytokine activityGO:0051258.6IL2, IL4, IL5, IL13

Products for genes affiliated with Angiostrongyliasis

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  • Antibodies
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Sources for Angiostrongyliasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet