MCID: ANG002
MIFTS: 52

Angiostrongyliasis malady

Rare diseases, Infectious diseases categories
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Summaries for Angiostrongyliasis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by angiostrongylus cantonensis or angiostrongylus costaricensis.

MalaCards: Angiostrongyliasis is related to eosinophilia and meningitis. An important gene associated with Angiostrongyliasis is IL13 (interleukin 13), and among its related pathways are Selected targets of GCR alpha and Hematopoietic cell lineage. The compounds omalizumab and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and testes, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Wikipedia:65 Angiostrongyliasis is an infection by a nematode from the Angiostrongylus genus of kidney and alimentary... more...

Aliases & Classifications for Angiostrongyliasis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Aliases & Descriptions:

angiostrongyliasis 8 43 10 49 62


External Ids:

Disease Ontology8 DOID:0050256
MESH via Orphanet36 C536369
ICD10 via Orphanet26 B81.3, B83.2
SNOMED-CT via Orphanet59 61750000
UMLS via Orphanet63 C0392662
ICD1025 B83.2

Related Diseases for Angiostrongyliasis

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17GeneCards, 18GeneDecks
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Diseases related to Angiostrongyliasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia29.9IL2, IL4, CCL24, IL5, IL13
2meningitis10.5
3eosinophilic meningitis10.5
4meningoencephalitis10.2
5neuritis10.2
6optic neuritis10.2
7kimura disease10.1IL5
8eosinophilic esophagitis10.1IL5
9sinusitis10.1IL5
10leprosy10.1IL2
11periapical granuloma10.1IL4
12keratoconjunctivitis10.1IL5, IL13
13helminthiasis10.1IL5, IL13
14eosinophilic pneumonia10.1IL5, IL13
15filariasis10.1IL13, IL5
16esophagitis10.1IL13, IL5
17mastocytosis10.1IL13, IL5
18bronchiolitis10.1IL5, IL13
19egg allergy10.0IL4, IL5
20intrinsic asthma10.0IL5, IL4
21allergic bronchopulmonary aspergillosis10.0IL5, IL4
22omenn syndrome10.0IL4, IL5
23mycosis fungoides10.0IL2, IL5
24lepromatous leprosy10.0IL2, IL4
25diphtheria10.0IL2, IL13
26agammaglobulinemia10.0IL4, IL2
27acute graft versus host disease10.0IL2, IL4
28atopic dermatitis10.0IL13, IL4
29common variable immune deficiency10.0IL4, IL2
30pulmonary tuberculosis10.0IL4, IL2
31lymphopenia10.0IL4, IL2
32myasthenia gravis10.0IL2, IL4
33bullous pemphigoid10.0IL13, IL5, PLAU
34conjunctivochalasis10.0MMP9, PLAU
35tropical spastic paraparesis10.0MMP9, IL2
36connective tissue disease10.0IL4, IL2
37anisakiasis10.0
38meckel's diverticulum10.0
39appendicitis10.0
40abdominal aortic aneurysm10.0PLAU, MMP9
41allergic conjunctivitis10.0IL13, IL5, IL4
42ulcerative colitis10.0CCL24, IL13, IL4
43cutaneous leishmaniasis10.0IL5, IL4, IL13
44bone carcinoma10.0PLAU, MMP9
45pulmonary eosinophilia10.0IL4, IL5, IL13
46allergic rhinitis10.0IL13, IL5, IL4
47food allergy10.0IL4, IL5, IL13
48hypersensitivity reaction type ii disease10.0IL4, IL2
49skin disease10.0IL2, MMP9
50leishmaniasis10.0IL4, IL5, IL13

Graphical network of the top 20 diseases related to Angiostrongyliasis:



Diseases related to angiostrongyliasis

Symptoms for Angiostrongyliasis

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Drugs & Therapeutics for Angiostrongyliasis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Angiostrongyliasis

Search NIH Clinical Center for Angiostrongyliasis

Genetic Tests for Angiostrongyliasis

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Anatomical Context for Angiostrongyliasis

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33MalaCards
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MalaCards organs/tissues related to Angiostrongyliasis:

33
Eye, Kidney, Testes, Skin, Liver, Lung, Colon

Animal Models for Angiostrongyliasis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Angiostrongyliasis:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3PLAU, IL13, IL2, IL4
2MP:00020068.2MMP9, IL2, IL5, PLAU
3MP:00053708.2PLAU, IL5, IL2, IL4
4MP:00053817.5MMP9, IL4, IL2, IL5, IL13, PLAU
5MP:00053897.4MMP9, IL4, IL2, IL5, IL13, PLAU
6MP:00053787.4MMP9, IL4, IL2, IL5, IL13, PLAU
7MP:00053847.4MMP9, IL4, IL2, IL13, PLAU
8MP:00053767.3MMP9, IL4, IL2, IL5, IL13, PLAU
9MP:00053887.0PLAU, MMP9, CCL24, IL4, IL2, IL5
10MP:00053977.0MMP9, CCL24, IL4, IL2, IL5, IL13
11MP:00053876.9MMP9, CCL24, IL4, IL2, IL5, IL13

Publications for Angiostrongyliasis

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52PubMed
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Articles related to Angiostrongyliasis:

(show top 50)    (show all 128)
idTitleAuthorsYear
1
Angiostrongyliasis in Thailand: epidemiology and laboratory investigations. (23901379)
2013
2
Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis. (23390222)
2013
3
Anterior chamber angiostrongyliasis. (23846206)
2013
4
Lung CT findings of angiostrongyliasis cantonensis caused by Angiostrongylus cantonensis. (21513853)
2011
5
An outbreak of angiostrongyliasis in Guanging, People's Republic of China: migrants vulnerable to an emerging disease. (22299428)
2011
6
Treatment of angiostrongyliasis using a combination of albendazole and dexamethasone: the results of a retrospective and comparative study. (21294950)
2011
7
Human ocular angiostrongyliasis: a literature review. (21296846)
2011
8
Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban patients with angiostrongyliasis. (21363978)
2011
9
Outcomes in mice with abdominal angiostrongyliasis treated with enoxaparin. (21400113)
2011
10
Application of recombinant SMR-domain containing protein of angiostrongylus cantonensis in immunoblot diagnosis of human angiostrongyliasis. (21073053)
2010
11
Abdominal angiostrongyliasis caused by Angiostrongylus cantonensis: a possible cause of eosinophilic infiltration in human digestive tract. (19545957)
2010
12
Human angiostrongyliasis outbreak in Dali, China. (19771154)
2009
13
Immunological diagnosis of human angiostrongyliasis due to Angiostrongylus cantonensis (Nematoda: Angiostrongylidae). (19117782)
2009
14
Abdominal angiostrongyliasis: what does the rheumatologist must know about it? (20374358)
2009
15
Individual serological follow-up of patients with suspected or confirmed abdominal angiostrongyliasis. (18327506)
2008
16
Abdominal angiostrongyliasis in rodent experimental infection: evidence for systemic circulation of first stage larvae. (17561438)
2007
17
Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. (17703945)
2007
18
Ocular angiostrongyliasis in a child--first case report from India. (16186138)
2006
19
Abdominal angiostrongyliasis: a case with severe evolution. (16553328)
2005
20
Ocular Angiostrongyliasis: removal of a live nematode from the anterior chamber. (15232595)
2005
21
Angiostrongyliasis, Mainland China. (16355510)
2005
22
Ocular parastrongyliasis (=angiostrongyliasis): probable first report of human infection from a patient in Ceylon (Sri Lanka). (15828436)
2004
23
Diagnosis of abdominal angiostrongyliasis by PCR from sera of patients. (14743672)
2003
24
First report of human angiostrongyliasis acquired in Sydney. (14558868)
2003
25
Evaluation of human IgG subclass antibodies in the serodiagnosis of angiostrongyliasis. (12658452)
2003
26
Ocular angiostrongyliasis without meningitis symptoms in Okinawa, Japan. (12053973)
2002
27
Angiostrongyliasis: analysis of antigens of Angiostrongylus costaricensis adult worms versus IgG from infected patients with Angiostrongylus cantonensis. (11414459)
2000
28
Jejunal perforation caused by abdominal angiostrongyliasis. (10602548)
1999
29
Seroepidemiology of abdominal angiostrongyliasis: the standardization of an immunoenzymatic assay and prevalence of antibodies in two localities in southern Brazil. (9491104)
1997
30
Detection of circulating antigen by monoclonal antibodies for immunodiagnosis of angiostrongyliasis. (9158049)
1997
31
Angiostrongyliasis in a European patient: a rare cause of gangrenous ischemic enterocolitis. (8224660)
1993
32
Human anisakiasis misdiagnosed as abdominal angiostrongyliasis. (8443320)
1993
33
Clinical studies on angiostrongyliasis cantonensis among children in Taiwan. (1822885)
1991
34
Clinical and epidemiological aspects of abdominal angiostrongyliasis in southern Brazil. (1844964)
1991
35
Immunodiagnosis of angiostrongyliasis with monoclonal antibodies recognizing a circulating antigen of mol. wt 91,000 from Angiostrongylus cantonensis. (1869351)
1991
36
Histopathological criteria for the diagnosis of abdominal angiostrongyliasis. (1792232)
1991
37
Serological investigations of a suspected case of human angiostrongyliasis. (3235133)
1988
38
Abdominal angiostrongyliasis: a problem of public health. (15275575)
1985
39
ELISA testing in cases of clinical angiostrongyliasis in Thailand. (4023800)
1985
40
Eosinophilic radiculomyeloencephalitis: an angiostrongyliasis outbreak in American Samoa related to ingestion of Achatina fulica snails. (7149098)
1982
41
Three cases of worm proven human angiostrongyliasis in Taiwan. (7343202)
1981
42
Angiostrongyliasis in Australia. (6930222)
1980
43
Clinical observations and immunodiagnosis of angiostrongyliasis in North Taiwan. (7219318)
1980
44
Angiostrongyliasis cantonensis. (287448)
1979
45
Pathological findings in four cases of human angiostrongyliasis. (725653)
1978
46
Angiostrongyliasis in Indonesia: additional geographic and host occurrence records. (751218)
1978
47
Ocular angiostrongyliasis in Semarang, Central Java. (842785)
1977
48
Case of ocular angiostrongyliasis associated with eosinophilic meningitis. (5102754)
1971
49
Eosinophilic meningoencephalitis caused by angiostrongyliasis in Thailand. Autopsy report. (4952148)
1967
50
Second case of ocular angiostrongyliasis in Thailand. (5901630)
1966

Variations for Angiostrongyliasis

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Expression for genes affiliated with Angiostrongyliasis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Angiostrongyliasis

Search GEO for disease gene expression data for Angiostrongyliasis.

Pathways for genes affiliated with Angiostrongyliasis

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Sources:
50PathCards, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 54R&D Systems, 53QIAGEN, 61Tocris Bioscience
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Pathways related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL4, IL5
29.5IL5, IL4
39.5IL4, IL5
49.4MMP9, PLAU
59.4PLAU, MMP9
69.4PLAU, MMP9
7
Show member pathways
9.4PLAU, MMP9
89.4MMP9, PLAU
99.4PLAU, MMP9
109.4MMP9, PLAU
119.3IL13, IL2
12
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.2IL13, IL5, IL4
139.2IL13, IL5, IL4
14
Show member pathways
IL2 signaling events mediated by STAT538
9.1IL2, IL4
15
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1IL2, IL4
16
Show member pathways
8.9MMP9, CCL24, PLAU
17
Show member pathways
8.9IL2, IL5, IL13
18
Show member pathways
8.9IL13, IL5, IL2
19
Show member pathways
8.8IL13, IL2, IL4
208.7IL4, IL2, IL5
21
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.7IL4, IL2, IL5
22
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.7IL4, IL2, IL5
238.5IL2, IL4, MMP9
248.3IL4, IL2, IL5, IL13
25
Show member pathways
Type III interferon signaling38
8.3IL4, IL2, IL5, IL13
268.3IL4, IL2, IL5, IL13
278.3IL13, IL5, IL2, IL4
288.3IL13, IL5, IL2, IL4
29
Show member pathways
8.3IL13, IL5, IL2, IL4
30
Show member pathways
8.3IL13, IL5, IL2, IL4
31
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
32
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
33
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
34
Show member pathways
7.8CCL24, IL4, IL2, IL5, IL13
35
Show member pathways
7.8IL13, IL5, IL2, IL4, CCL24

Compounds for genes affiliated with Angiostrongyliasis

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1omalizumab45 1110.6IL13, IL4, IL5
2ovomucoid459.6IL4, IL5, IL13
3praziquantel45 1110.5IL5, IL4, IL13
4amphotericin b459.5IL4, IL5, IL13
5mip 1alpha459.5PLAU, IL13, IL4
6montelukast45 51 29 1112.5IL13, IL5, IL4
7budesonide45 51 1111.3IL5, IL13, IL4
8git 27619.2IL2, IL5, IL13
9rolipram45 61 2911.2IL5, IL4, IL13
104-ipp619.2IL5, IL13, IL2
11pirfenidone45 6110.2IL13, IL5, IL2
12as 10145 6110.2IL2, IL13, IL5
13alpha-galactosylceramide459.1IL4, IL2, IL13
14tdac459.1IL2, IL4
15c-d4t459.1IL4, IL5, IL2
16methacholine45 51 1111.1IL13, IL5, IL4
17erythromycin45 3 51 1112.1MMP9, IL5, IL13
18tarc459.1IL5, IL13, IL4, CCL24
19doxycycline45 1110.0IL5, IL13, PLAU, MMP9
20fluticasone propionate45 51 61 1112.0IL4, IL5, IL13, MMP9
21con a458.9IL4, IL2, IL5
22bleomycin45 119.9IL4, MMP9, IL5, IL13
23polyinosinic-polycytidylic acid458.8IL5, IL2, IL4
24glatiramer acetate45 119.8IL5, IL2, IL13, IL4
25salmeterol45 51 29 1111.8IL13, IL4, IL5, IL2
26il-12458.8IL2, IL5, IL13, IL4
27gm-csf45 299.8IL13, IL4, IL5, IL2
28il 10458.8IL13, IL4, IL2, IL5
29ionomycin458.6IL2, IL5, IL13, IL4
30ivig458.6IL4, IL5, MMP9
31tacrolimus45 51 1110.6IL2, IL4, IL5, IL13
32thapsigargin45 619.6IL4, IL13, PLAU, IL2
33calcitriol45 61 24 1111.5IL2, PLAU, IL4, IL13
34sb 20358045 619.5IL13, IL4, IL5, MMP9, PLAU
35ly294002458.5IL4, IL5, IL13, PLAU, MMP9
36cyclophosphamide45 51 1110.4MMP9, IL4, IL2, IL13
37adenylate458.4IL4, PLAU, IL13, IL5, MMP9
38hydrocortisone45 3 61 1111.3IL4, IL2, PLAU, IL5, IL13
39indomethacin45 29 61 1111.3IL5, PLAU, IL13, IL2, IL4
40thymidine45 249.2IL2, PLAU, IL13, IL4, IL5
41cyclosporin a45 29 6110.1MMP9, IL4, IL2, IL13, IL5
42herbimycin a45 619.1MMP9, IL5, IL2, IL4, PLAU
43dexamethasone45 51 29 1110.9IL13, IL5, MMP9, IL2, IL4
44histamine45 29 249.8IL2, CCL24, IL4, IL5, IL13, PLAU
45pge2457.7MMP9, IL2, IL5, PLAU, IL13, IL4
46cycloheximide457.7MMP9, IL2, PLAU, IL13, IL5, IL4
47vegf457.7IL13, PLAU, IL2, IL4, MMP9, IL5
48rantes457.7IL5, IL2, IL4, CCL24, MMP9, IL13
49actinomycin d457.6IL2, IL4, MMP9, PLAU, CCL24, IL13
50tyrosine457.4MMP9, IL4, IL2, IL5, IL13, PLAU

GO Terms for genes affiliated with Angiostrongyliasis

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16Gene Ontology
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Cellular components related to Angiostrongyliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8MMP9, IL2, IL5, IL13, PLAU
2extracellular spaceGO:0056156.4MMP9, CCL24, IL4, IL2, IL5, IL13

Biological processes related to Angiostrongyliasis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:0101559.8IL13, IL4
2positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5IL5, IL4
3positive regulation of immunoglobulin secretionGO:0510249.5IL5, IL2
4positive regulation of isotype switching to IgG isotypesGO:0483049.4IL2, IL4
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.3IL4, IL2
6response to ethanolGO:0454719.3IL4, IL13
7positive regulation of activated T cell proliferationGO:0421049.3IL4, IL2
8inflammatory responseGO:0069549.2IL13, IL5, CCL24
9chemotaxisGO:0069359.2PLAU, CCL24, IL4
10extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.1IL2, IL4
11positive regulation of inflammatory responseGO:0507299.0IL2, CCL24
12cell-cell signalingGO:0072678.9CCL24, IL13, IL2
13positive regulation of B cell proliferationGO:0308908.6IL2, IL13, IL5, IL4
14immune responseGO:0069558.1CCL24, IL4, IL2, IL5, IL13

Molecular functions related to Angiostrongyliasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080838.7IL5, IL2, IL4
2cytokine activityGO:0051258.0IL13, IL5, IL2, IL4

Products for genes affiliated with Angiostrongyliasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Angiostrongyliasis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet