MCID: ANG002
MIFTS: 44

Angiostrongyliasis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Angiostrongyliasis

MalaCards integrated aliases for Angiostrongyliasis:

Name: Angiostrongyliasis 12 72 49 55 14 69

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050256
Orphanet 55 ORPHA74
MESH via Orphanet 42 C536369
UMLS via Orphanet 70 C0392662
ICD10 via Orphanet 33 B81.3 B83.2
ICD10 32 B83.2
UMLS 69 C0392662

Summaries for Angiostrongyliasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis.

MalaCards based summary : Angiostrongyliasis is related to eosinophilic meningitis and meningitis. An important gene associated with Angiostrongyliasis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and testes, and related phenotypes are digestive/alimentary and hematopoietic system

Wikipedia : 72 Angiostrongyliasis is a zoonotic infection by a nematode from the Angiostrongylus genus of kidney and... more...

Related Diseases for Angiostrongyliasis

Diseases related to Angiostrongyliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 eosinophilic meningitis 28.4 CCL11 IL13 IL4 IL5 MMP9 PLAU
2 meningitis 10.4
3 corneal ulcer 10.3 CCL11 MMP9
4 intratubular embryonal carcinoma 10.3 MMP9 PLAU
5 pemphigoid gestationis 10.2 CCL11 IL5
6 eosinophilic gastroenteritis 10.1 CCL11 IL5
7 chronic eosinophilic pneumonia 10.1 CCL11 IL5
8 tropical spastic paraparesis 10.1 IL2 MMP9
9 cytokine deficiency 10.1 IL13 IL5
10 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL13 IL5
11 respiratory syncytial virus infectious disease 10.1 IL13 IL5
12 paragonimiasis 10.1 IL13 IL5
13 nut allergy 10.1 IL13 IL5
14 night blindness, congenital stationary, type 1a 10.0 IL13 IL5
15 radiation cystitis 10.0 IL13 IL5
16 optic neuritis 10.0
17 neuritis 10.0
18 pollen allergy 10.0 IL13 IL5
19 chromoblastomycosis 10.0 IL4 MMP9
20 blepharoconjunctivitis 10.0 CCL11 IL4
21 wells syndrome 10.0 IL2 IL5
22 papillary conjunctivitis 10.0 CCL11 IL4
23 esophageal disease 10.0 IL13 IL5
24 giant papillary conjunctivitis 10.0 CCL11 IL4
25 mast cell disease 10.0 IL13 IL5
26 meningoencephalitis 10.0
27 gnathomiasis 10.0
28 appendicitis 10.0
29 secondary progressive multiple sclerosis 9.9 IL4 MMP9
30 virus associated hemophagocytic syndrome 9.9 IL2 IL4
31 dermatitis herpetiformis 9.9 CCL11 IL4
32 chronic meningitis 9.9 CCL11 IL5 MMP9
33 penicillin allergy 9.9 IL13 IL4
34 filariasis 9.9 IL2 IL5
35 jak3-deficient severe combined immunodeficiency 9.9 IL2 IL4
36 beta-lactam allergy 9.9 IL13 IL4
37 microscopic colitis 9.9 IL2 IL4
38 vulvovaginal candidiasis 9.9 IL2 IL4
39 coccidiosis 9.9 IL2 IL4
40 severe combined immunodeficiency, x-linked 9.9 IL2 IL4
41 gingivitis 9.9 IL4 MMP9
42 cough variant asthma 9.9 IL4 IL5
43 acute graft versus host disease 9.8 IL2 IL4
44 egg allergy 9.8 IL4 IL5
45 trichinosis 9.8 IL4 IL5
46 non-suppurative otitis media 9.8 IL4 IL5
47 ovarian cancer 1 9.8 IL2 MMP9
48 intrinsic asthma 9.8 IL4 IL5
49 vernal conjunctivitis 9.8 IL2 IL4
50 brucellosis 9.8 IL2 IL4

Graphical network of the top 20 diseases related to Angiostrongyliasis:



Diseases related to Angiostrongyliasis

Symptoms & Phenotypes for Angiostrongyliasis

MGI Mouse Phenotypes related to Angiostrongyliasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.88 IL4 IL5 MMP9 IL13 PLAU IL2
2 hematopoietic system MP:0005397 9.87 IL4 IL5 CCL11 MMP9 IL13 PLAU
3 growth/size/body region MP:0005378 9.85 IL4 IL5 MMP9 IL13 PLAU IL2
4 immune system MP:0005387 9.8 IL4 IL5 CCL11 MMP9 IL13 PLAU
5 neoplasm MP:0002006 9.46 IL5 MMP9 PLAU IL2
6 reproductive system MP:0005389 9.43 IL4 IL5 MMP9 IL13 PLAU IL2
7 respiratory system MP:0005388 9.17 IL5 CCL11 MMP9 IL13 PLAU IL2

Drugs & Therapeutics for Angiostrongyliasis

Drugs for Angiostrongyliasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Not yet recruiting NCT03378882

Search NIH Clinical Center for Angiostrongyliasis

Genetic Tests for Angiostrongyliasis

Anatomical Context for Angiostrongyliasis

MalaCards organs/tissues related to Angiostrongyliasis:

38
Eye, Kidney, Testes, Skin, Liver, Colon, Lung

Publications for Angiostrongyliasis

Articles related to Angiostrongyliasis:

(show top 50) (show all 143)
# Title Authors Year
1
Diagnosing and Understanding Angiostrongyliasis, A Zoonotic Cause of Meningitis. ( 29411969 )
2018
2
High-dose enoxaparin in the treatment of abdominal angiostrongyliasis in Swiss mice. ( 28969719 )
2017
3
Abdominal Angiostrongyliasis: A Presentation of Eosinophilic Granulomatous Colitis. ( 29278974 )
2017
4
First Evidence of Angiostrongyliasis Caused by Angiostrongylus cantonensis in Guadeloupe, Lesser Antilles. ( 28070007 )
2017
5
Angiostrongyliasis (Rat Lungworm Disease): Viewpoints from Hawai'i Island. ( 28820576 )
2017
6
Cloning and expression of a 16-kDa recombinant protein from Angiostrongylus cantonensis for use in immunoblot diagnosis of human angiostrongyliasis. ( 27406573 )
2016
7
Abdominal angiostrongyliasis mimicking acute appendicitis. ( 25928828 )
2015
8
A Case of Ocular Angiostrongyliasis with Molecular Identification of the Species in Vietnam. ( 26797438 )
2015
9
Emergence of neural angiostrongyliasis in eastern australia. ( 25793473 )
2015
10
Follow-up on anterior chamber angiostrongyliasis. ( 25124954 )
2014
11
Acute eosinophilic meningitis and orbital inflammation from presumed angiostrongyliasis. ( 24862785 )
2014
12
PCR for the diagnosis of abdominal angiostrongyliasis in formalin-fixed paraffin-embedded human tissue. ( 24705328 )
2014
13
Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis. ( 23390222 )
2013
14
Endemic angiostrongyliasis in the Brazilian Amazon: natural parasitism of Angiostrongylus cantonensis in Rattus rattus and R. norvegicus, and sympatric giant African land snails, Achatina fulica. ( 23072946 )
2013
15
Subretinal angiostrongyliasis-induced optic neuritis. ( 23818750 )
2013
16
Neuroimaging features in neuro-gnathostomiasis and angiostrongyliasis. ( 22271262 )
2013
17
Comprehensive review of ocular angiostrongyliasis with special reference to optic neuritis. ( 24516263 )
2013
18
Differential diagnosis of CNS angiostrongyliasis: a short review. ( 23901385 )
2013
19
Angiostrongyliasis in Thailand: epidemiology and laboratory investigations. ( 23901379 )
2013
20
Anterior chamber angiostrongyliasis. ( 23846206 )
2013
21
Pathways for transmission of angiostrongyliasis and the risk of disease associated with them. ( 23901388 )
2013
22
The role of eosinophils in angiostrongyliasis: multiple roles for a versatile cell? ( 23901384 )
2013
23
How can clinicians ensure the diagnosis of meningitic angiostrongyliasis? ( 21923259 )
2012
24
A comparative study of neuroimaging features between human neuro-gnathostomiasis and angiostrongyliasis. ( 22124854 )
2012
25
Enzootic angiostrongyliasis in Guangzhou, China, 2008-2010. ( 22556086 )
2012
26
Workshop on research priorities for management and treatment of angiostrongyliasis(1). ( 23171634 )
2012
27
Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban patients with angiostrongyliasis. ( 21363978 )
2011
28
An outbreak of angiostrongyliasis in Guanging, People's Republic of China: migrants vulnerable to an emerging disease. ( 22299428 )
2011
29
Treatment of angiostrongyliasis using a combination of albendazole and dexamethasone: the results of a retrospective and comparative study. ( 21294950 )
2011
30
Human ocular angiostrongyliasis: a literature review. ( 21296846 )
2011
31
Outcomes in mice with abdominal angiostrongyliasis treated with enoxaparin. ( 21400113 )
2011
32
Endemic angiostrongyliasis, Rio de Janeiro, Brazil. ( 21762612 )
2011
33
Development of a double antibody sandwich ELISA assay for the diagnosis of angiostrongyliasis. ( 21506824 )
2011
34
Enzootic angiostrongyliasis, Guangdong, China, 2008-2009. ( 21762614 )
2011
35
Lung CT findings of angiostrongyliasis cantonensis caused by Angiostrongylus cantonensis. ( 21513853 )
2011
36
International symposium on Angiostrongylus and Angiostrongyliasis, 2010. ( 21762566 )
2011
37
Abdominal angiostrongyliasis with involvement of liver histopathologically confirmed: a case report. ( 21915466 )
2011
38
An indirect immunofluorescence antibody test employing whole eggs as the antigen for the diagnosis of abdominal angiostrongyliasis. ( 21739024 )
2011
39
Use of heterologous antigens for the immunodiagnosis of abdominal angiostrongyliasis by an enzyme-linked immunosorbent assay. ( 21120363 )
2010
40
Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals. ( 21120370 )
2010
41
Abdominal angiostrongyliasis caused by Angiostrongylus cantonensis: a possible cause of eosinophilic infiltration in human digestive tract. ( 19545957 )
2010
42
Application of recombinant SMR-domain containing protein of angiostrongylus cantonensis in immunoblot diagnosis of human angiostrongyliasis. ( 21073053 )
2010
43
Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. ( 20584616 )
2010
44
Identification of factors associated with clinically severe angiostrongyliasis. ( 21118948 )
2010
45
Human angiostrongyliasis outbreak in Dali, China. ( 19771154 )
2009
46
Ocular angiostrongyliasis--first case report from Jamaica. ( 20099782 )
2009
47
Immunological diagnosis of human angiostrongyliasis due to Angiostrongylus cantonensis (Nematoda: Angiostrongylidae). ( 19117782 )
2009
48
Abdominal angiostrongyliasis: what does the rheumatologist must know about it? ( 20374358 )
2009
49
Thai koi-hoi snail dish and angiostrongyliasis due to Angiostrongylus cantonensis: Effects of food flavoring and alcoholic drink on the third-stage larvae in infected snail meat. ( 19272010 )
2009
50
Angiostrongyliasis in the Americas. ( 19523320 )
2009

Variations for Angiostrongyliasis

Expression for Angiostrongyliasis

Search GEO for disease gene expression data for Angiostrongyliasis.

Pathways for Angiostrongyliasis

Pathways related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL11 IL13 IL2 IL4 IL5 MMP9
2
Show member pathways
13.4 CCL11 IL13 IL2 IL4 IL5
3
Show member pathways
13.29 CCL11 IL13 IL2 IL4 IL5
4
Show member pathways
13.18 CCL11 IL13 IL2 IL4 IL5
5
Show member pathways
13.16 CCL11 IL13 IL2 IL4 IL5 MMP9
6
Show member pathways
13.09 CCL11 IL13 IL2 IL4 IL5
7 12.67 IL13 IL2 IL4 IL5 MMP9
8
Show member pathways
12.66 CCL11 IL13 IL2 IL4 IL5
9
Show member pathways
12.44 IL13 IL2 IL4 IL5
10
Show member pathways
12.38 IL13 IL4 IL5
11
Show member pathways
12.25 IL13 IL2 IL5
12
Show member pathways
12.24 IL13 IL2 IL4 IL5
13
Show member pathways
12.23 IL2 IL4 IL5
14
Show member pathways
12.1 CCL11 IL13 IL4 IL5 MMP9
15
Show member pathways
12.01 IL13 IL2 IL4 IL5
16
Show member pathways
11.89 IL13 IL2 IL5
17 11.87 IL2 IL4 MMP9
18 11.85 IL2 IL4 IL5
19 11.84 CCL11 IL13 IL4 MMP9
20 11.67 IL13 IL2 IL4 IL5
21
Show member pathways
11.65 IL2 IL4 IL5
22 11.61 IL13 IL2 IL4 IL5
23 11.56 CCL11 IL4 IL5
24 11.5 MMP9 PLAU
25
Show member pathways
11.48 IL2 MMP9
26 11.46 MMP9 PLAU
27 11.36 IL13 IL4
28 11.35 MMP9 PLAU
29 11.34 MMP9 PLAU
30
Show member pathways
11.31 MMP9 PLAU
31 11.23 IL2 IL4 IL5
32 11.19 IL13 IL4 IL5
33 11.17 MMP9 PLAU
34 11.08 IL13 IL2
35 11.03 IL13 IL2 IL4 IL5
36 11.02 CCL11 IL13 IL2 IL4 IL5
37 10.95 CCL11 IL13 IL2 IL4 IL5
38 10.9 CCL11 IL13 IL4 IL5 MMP9 PLAU
39 10.87 CCL11 IL13 IL2 IL4 IL5
40 10.87 IL13 IL2 IL4 IL5
41 10.69 IL13 IL4 IL5

GO Terms for Angiostrongyliasis

Cellular components related to Angiostrongyliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 IL13 IL2 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.17 CCL11 IL13 IL2 IL4 IL5 MMP9

Biological processes related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.69 CCL11 IL13 IL5
2 positive regulation of cell migration GO:0030335 9.63 CCL11 MMP9 PLAU
3 chemotaxis GO:0006935 9.58 CCL11 IL4 PLAU
4 immune response GO:0006955 9.55 CCL11 IL13 IL2 IL4 IL5
5 positive regulation of T cell proliferation GO:0042102 9.49 IL2 IL4
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 IL13 IL4
7 positive regulation of T cell differentiation GO:0045582 9.43 IL2 IL4
8 regulation of receptor activity GO:0010469 9.43 CCL11 IL13 IL2 IL4 IL5 PLAU
9 positive regulation of immunoglobulin secretion GO:0051024 9.37 IL2 IL5
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 IL2 IL4
11 negative regulation of complement-dependent cytotoxicity GO:1903660 9.26 IL13 IL4
12 positive regulation of B cell proliferation GO:0030890 8.92 IL13 IL2 IL4 IL5

Molecular functions related to Angiostrongyliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IL13 IL4
2 growth factor activity GO:0008083 9.13 IL2 IL4 IL5
3 cytokine activity GO:0005125 9.02 CCL11 IL13 IL2 IL4 IL5

Sources for Angiostrongyliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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