Aliases & Classifications for Anhidrosis

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Aliases & Descriptions for Anhidrosis:

Name: Anhidrosis 11 50 13 68
Absence of Sweating 11
 
Adiaphoresis 11

Classifications:



External Ids:

Disease Ontology11 DOID:11156
ICD1030 L74.4
ICD9CM32 705.0
MeSH39 D007007
NCIt45 C34385

Summaries for Anhidrosis

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Wikipedia:71 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards based summary: Anhidrosis, also known as absence of sweating, is related to pyruvate kinase deficiency and insensitivity to pain, congenital, with anhidrosis, and has symptoms including increased sweating, cold sweat and night sweats. An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways are Activation of TRKA receptors and 14-3-3 and Regulation of BAD Activity. Affiliated tissues include skin, testes and t cells, and related mouse phenotypes are integument and muscle.

Related Diseases for Anhidrosis

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Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1pyruvate kinase deficiency29.5NTRK1, PKLR
2insensitivity to pain, congenital, with anhidrosis12.3
3anhidrosis, isolated, with normal sweat glands12.1
4isolated generalized anhidrosis with normal sweat glands11.8
5harlequin syndrome11.4
6hypohidrosis11.3
7horner's syndrome11.0
8van den bosch syndrome10.8
9ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive10.7
10ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant10.7
11ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.7
12ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.7
13ichthyosis, congenital, autosomal recessive 4a10.7
14ichthyosis, congenital, autosomal recessive 610.7
15ichthyosis, congenital, autosomal recessive 1010.7
16ichthyosis, congenital, autosomal recessive 810.7
17ichthyosis, congenital, autosomal recessive 1110.7
18ichthyosis, congenital, autosomal recessive 710.7
19immunodeficiency 910.7
20ichthyosis, congenital, autosomal recessive 110.7
21ichthyosis, congenital, autosomal recessive 910.7
22ichthyosis, congenital, autosomal recessive 210.7
23ichthyosis, congenital, autosomal recessive 310.7
24ichthyosis, congenital, autosomal recessive 510.7
25ectodermal dysplasia 1, hypohidrotic, x-linked10.7
26splenomegaly, cytopenia, and vision loss10.7
27horner syndrome, congenital10.7
28neuropathy, hereditary sensory and autonomic, type v10.3NGF, NTRK1
29pharynx carcinoma in situ10.3NGF, NTRK1
30c5 deficiency10.3NGF, NTRK1
31neuropathy10.3
32pseudoainhum10.2NGF, NGFR
33anal colloid adenocarcinoma10.2NGFR, NTRK1
34scleroperikeratitis10.2GLA, NTRK1
35epidermolysis bullosa simplex superficialis10.1NGF, NTRK1
36diffuse large b-cell lymphoma10.1NGF, NTRK1
37rumination disorder10.0NGF, NTRK1
38autonomic neuropathy10.0
39esophagitis10.0NGF, NGFR, NTRK1
40alopecia9.9
41ectodermal dysplasia9.9
42miliaria9.9
43pheochromocytoma9.9NGF, NGFR, NTRK1
44papillary serous adenocarcinoma9.9NGF, NTRK1
45adenosquamous cell lung carcinoma9.9NTRK1, NTRK3
46lung large cell carcinoma9.8NGFR, NTRK3
47multiple system atrophy9.8
48cholinergic urticaria9.8
49urticaria9.8
50dermatitis9.8

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to anhidrosis

Symptoms & Phenotypes for Anhidrosis

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UMLS symptoms related to Anhidrosis:


increased sweating, cold sweat, night sweats

MGI Mouse Phenotypes related to Anhidrosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.4IKBKG, ITPR2, NGF, NGFR, NTRK1
2MP:00053698.7CHRM3, GLA, NGF, NGFR, NTRK1
3MP:00028738.3IKBKG, ITPR2, NGF, NGFR, NTRK1, NTRK3
4MP:00053857.8CHRM3, GLA, IKBKG, ITPR2, NGF, NGFR
5MP:00053767.8CHRM3, GLA, IKBKG, ITPR2, NGF, NGFR
6MP:00107687.5GLA, IKBKG, ITPR2, NGF, NGFR, NTRK1
7MP:00053867.5CHRM3, GLA, IKBKG, ITPR2, NGF, NGFR
8MP:00053787.4CHRM3, GLA, IKBKG, ITPR2, NGF, NGFR
9MP:00053917.4CHRM3, GLA, NGF, NGFR, NTRK1, NTRK3

Drugs & Therapeutics for Anhidrosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and AnhidrosisWithdrawnNCT02624310Phase 2

Search NIH Clinical Center for Anhidrosis

Genetic Tests for Anhidrosis

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Anatomical Context for Anhidrosis

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MalaCards organs/tissues related to Anhidrosis:

36
Skin, Testes, T cells, Neutrophil, Bone, Lung, Spinal cord

Publications for Anhidrosis

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Articles related to Anhidrosis:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Harlequin syndrome with contralateral anhidrosis after an upper chest gunshot wound. (27535737)
2016
2
Raeder's Paratrigeminal Syndrome: Headache and Horner's Lacking Anhidrosis. (26902244)
2016
3
Purple hands in multiple system atrophy: Global anhidrosis with preserved acral sweating. (27298449)
2016
4
Unilateral anhidrosis: A rare complication of thoracic epidural analgesia. (26612960)
2016
5
Generalised Anhidrosis Secondary to Intracranial Haemorrhage. (27125348)
2016
6
Genetic Disorders with Dyshidrosis: Ectodermal Dysplasia, Incontinentia Pigmenti, Fabry Disease, and Congenital Insensitivity to Pain with Anhidrosis. (27584961)
2016
7
Orthopaedic manifestations of congenital indifference to pain with anhidrosis (Hereditary Sensory and Autonomic Neuropathy type IV). (27637569)
2016
8
A Girl with No Pain: Congenital Insensitivity To Pain and Anhidrosis (HSAN) Type IV - A Case Report. (27042602)
2016
9
Congenital Insensitivity to Pain and Anhidrosis. (26848454)
2016
10
Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction. (27859565)
2016
11
Idiopathic segmental anhidrosis associated with varicella. (27206820)
2016
12
Mutations in TrkA causing congenital insensitivity to pain with anhidrosis (CIPA) induce misfolding, aggregation and mutation-dependent neurodegeneration by dysfunction of the autophagic flux. (27551041)
2016
13
Anesthetic considerations in a parturient with congenital insensitivity to pain with anhidrosis. (27884666)
2016
14
Acquired anhidrosis in a case of autoimmune autonomic ganglionopathy. (27774700)
2016
15
Congenital insensitivity to pain with anhidrosis: A report of two siblings with a novel mutation in (TrkA) NTRK1 gene in a Saudi family. (27772781)
2016
16
Congenital insensitivity to pain and anhidrosis: Case report and review of findings along neuro-immune axis in the disorder. (27772759)
2016
17
Phenotypes and Genotypes in Five Children with Congenital Insensitivity to Pain with Anhidrosis. (27265460)
2016
18
Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan. (27774633)
2016
19
Clinical Analysis and Management of Acquired Idiopathic Generalized Anhidrosis. (27584965)
2016
20
Anesthetic Management of Patients with Congenital Insensitivity to Pain with Anhidrosis: A Retrospective Analysis of 358 Procedures Performed Under General Anesthesia. (26484462)
2015
21
A lady presenting with segmental anhidrosis and heat intolerance. (25821738)
2015
22
Update Review and Clinical Presentation in Congenital Insensitivity to Pain and Anhidrosis. (26579324)
2015
23
Acquired Idiopathic Generalized Anhidrosis. (26288446)
2015
24
Therapeutic effects and prevention of recurrence of acquired idiopathic generalized anhidrosis via i.v. immunoglobulin treatment. (26508392)
2015
25
Congenital Insensitivity to Pain with Anhidrosis in Twin Sisters with Sensorineural Deafness. (25776000)
2015
26
Correlation of disease activity and serum level of carcinoembryonic antigen in acquired idiopathic generalized anhidrosis: A case report. (25958966)
2015
27
Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. (25627679)
2015
28
Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum CEA level and disease activity. (26446433)
2015
29
Congenital insensitivity to pain with anhidrosis. (26032179)
2015
30
Combined cholinergic urticaria and cold-induced cholinergic urticaria with acquired idiopathic generalized anhidrosis. (25838106)
2015
31
Congenital Insensitivity to Pain without Anhidrosis: Orodental Problems and Management. (26457210)
2015
32
Novel and novel de novo mutations in NTRK1 associated with congenital insensitivity to pain with anhidrosis: a case report. (25984678)
2015
33
Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis. (25060903)
2014
34
A case of congenital insensitivity to pain with anhidrosis. (26078659)
2014
35
Acquired idiopathic anhidrosis: a diagnosis often missed. (24856478)
2014
36
Skeletal complications in congenital insensitivity to pain with anhidrosis: a case series of 14 patients and review of articles published in Japanese. (24953503)
2014
37
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. (23748235)
2014
38
Novel NTRK1 Frameshift Mutation in Congenital Insensitivity to Pain With Anhidrosis. (25316729)
2014
39
Congenital insensitivity to pain and anhidrosis syndrome: two cases involving a brother and sister. (25421205)
2014
40
A case of acquired idiopathic generalized anhidrosis in a 2-year-old infant. (24698553)
2014
41
Correlating interleukin-12 stimulated interferon-I^ production and the absence of ectodermal dysplasia and anhidrosis (EDA) in patients with mutations in NF-I_B essential modulator (NEMO). (24682681)
2014
42
Photoletter to the editor: Acquired idiopathic generalized anhidrosis. (25621094)
2014
43
A novel NTRK1 mutation in a patient with congenital insensitivity to pain with anhidrosis. (25519000)
2014
44
Acquired Idiopathic Generalized Anhidrosis: An Immunohistopathological Investigation of Peri-glands Infiltrated with Immunoreactive Cells. (25519938)
2014
45
Two cases of acquired idiopathic generalized anhidrosis successfully treated by steroid pulse therapy. (24801920)
2014
46
Partial anhidrosis demonstrated by Q-SART in a patient with a novel mutation in the EDARADD gene. (24666190)
2014
47
Investigation of antimuscarinic receptor autoantibodies in patients with acquired idiopathic generalized anhidrosis. (24334576)
2013
48
Oral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosis. (23799134)
2013
49
Acquired generalised anhidrosis presenting with heat retention after carboplatin and paclitaxel treatment. (24192525)
2013
50
Congenital insensitivity to pain with anhidrosis in an Iranian patient. (25337332)
2013

Variations for Anhidrosis

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Expression for genes affiliated with Anhidrosis

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Search GEO for disease gene expression data for Anhidrosis.

Pathways for genes affiliated with Anhidrosis

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Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8NGF, NTRK1
29.6NGF, NGFR
39.6NTRK1, NTRK3
4
Show member pathways
9.2IKBKG, NGF, NGFR
5
Show member pathways
9.2IKBKG, NGF, NGFR
6
Show member pathways
9.0IKBKG, ITPR2, NGF, NTRK1
7
Show member pathways
9.0IKBKG, ITPR2, NGF, NTRK1
8
Show member pathways
9.0CHRM3, ITPR2, PKLR
9
Show member pathways
8.9IKBKG, NGF, NGFR, NTRK1
108.9ITPR2, NGF, NTRK1, NTRK3
11
Show member pathways
8.9IKBKG, ITPR2, NGF, NGFR
12
Show member pathways
8.9IKBKG, ITPR2, NTRK1, NTRK3
13
Show member pathways
8.8NGF, NGFR, NTRK1, NTRK3
14
Show member pathways
8.8NGF, NGFR, NTRK1, NTRK3
158.8NGF, NGFR, NTRK1, NTRK3
168.8NGF, NGFR, NTRK1, NTRK3
178.8NGF, NGFR, NTRK1, NTRK3
18
Show member pathways
8.8NGF, NGFR, NTRK1, NTRK3
19
Show member pathways
8.8IKBKG, NGFR, NTRK1, NTRK3
20
Show member pathways
8.5ITPR2, NGF, NGFR, NTRK1, NTRK3
21
Show member pathways
8.5ITPR2, NGF, NGFR, NTRK1, NTRK3
22
Show member pathways
8.4IKBKG, NGF, NGFR, NTRK1, NTRK3
23
Show member pathways
8.4IKBKG, NGF, NGFR, NTRK1, NTRK3
24
Show member pathways
8.4IKBKG, NGF, NGFR, NTRK1, NTRK3
25
Show member pathways
8.0IKBKG, ITPR2, NGF, NGFR, NTRK1, NTRK3
26
Show member pathways
8.0IKBKG, ITPR2, NGF, NGFR, NTRK1, NTRK3

GO Terms for genes affiliated with Anhidrosis

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Cellular components related to Anhidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:00057689.9NGF, NGFR, NTRK1
2receptor complexGO:00432359.3ITPR2, NTRK1, NTRK3

Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:000018610.5NGF, NTRK1
2negative regulation of neuron deathGO:190121510.4IKBKG, NTRK1
3positive regulation of Ras protein signal transductionGO:004657910.3NGF, NTRK1
4mechanoreceptor differentiationGO:004249010.3NTRK1, NTRK3
5positive regulation of axonogenesisGO:005077210.2NGF, NGFR
6positive regulation of synaptic transmission, glutamatergicGO:005196810.1NGFR, NTRK1
7positive regulation of synapse assemblyGO:005196510.1NTRK1, NTRK3
8regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004328110.0NGF, NGFR
9negative regulation of neuron apoptotic processGO:004352410.0NGF, NGFR, NTRK1
10neurotrophin TRK receptor signaling pathwayGO:004801110.0NGF, NGFR, NTRK1
11positive regulation of apoptotic processGO:00430659.7NGF, NGFR, NTRK3
12response to axon injuryGO:00486789.6NTRK1, NTRK3

Molecular functions related to Anhidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1GPI-linked ephrin receptor activityGO:00050049.8NTRK1, NTRK3
2nerve growth factor bindingGO:00484069.7NGFR, NTRK1
3neurotrophin bindingGO:00431219.6NTRK1, NTRK3

Sources for Anhidrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet