MCID: ANH002
MIFTS: 52

Anhidrosis malady

Skin diseases category

Summaries for Anhidrosis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards: Anhidrosis, also known as absence of sweating, is related to neuropathy and autonomic neuropathy. An important gene associated with Anhidrosis is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are Thyroid cancer and p75NTR signals via NF-kB. The compounds forskolin and serine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related mouse phenotypes are integument and no phenotypic analysis.

Description from OMIM:46 206600

Aliases & Classifications for Anhidrosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

anhidrosis 8 10 44 60
absence of sweating 8
adiaphoresis 8


External Ids:

Disease Ontology8 DOID:11156
MeSH34 D007007
NCIt39 C34385
OMIM46 206600
ICD9CM27 705.0
ICD1025 L74.4

Related Diseases for Anhidrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anhidrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy30.8NGF, IKBKAP
2autonomic neuropathy30.3IKBKAP, NGF, NTRK1
3hereditary sensory neuropathy30.3NTRK1, NGF, IKBKAP
4hypohidrosis30.3GLA
5diabetic neuropathy29.8NGF, NGFR, NTRK1
6atopic dermatitis29.7NGF, NGFR, BDNF
7skin disease29.7ALOX12B, NGFR, BDNF
8multiple sclerosis29.7BDNF, MAPK10, NGFR, NGF
9hereditary sensory and autonomic neuropathy iv10.6
10alopecia10.2
11miliaria10.2
12pain disorder10.2
13horner's syndrome10.2
14dermatitis10.1
15sialadenitis10.0
16cholinergic urticaria10.0
17impotence10.0
18leprosy10.0
19urticaria10.0
20vasculitis10.0
21chagas disease10.0NTRK1
22peripheral neuropathy10.0NTRK1
23phaeochromocytoma10.0NGF
24myocardial infarction10.0GLA
25pyruvate kinase deficiency10.0PKLR
26ependymoma10.0NGFR
27neuroaxonal dystrophy10.0NTRK1, NGF
28acute leukemia10.0MAPK10
29down syndrome10.0MAPK10
30allergic rhinitis10.0NGFR, NGF
31prolactinoma10.0NGF, NGFR
32diabetes mellitus10.0PKLR, NGF
33pancreatitis10.0MAPK10
34autosomal recessive congenital ichthyosis10.0ALOXE3, ALOX12B
35hyperglycemia10.0BDNF
36ganglioneuroma10.0NGF, NGFR, NTRK1
37attention deficit hyperactivity disorder10.0BDNF
38cannabis abuse10.0NGF, BDNF
39gaucher's disease10.0GLA, PKLR
40myopathy10.0IKBKAP, NGF, PKLR
41papillary thyroid carcinoma10.0NTRK1, MAPK10
42congenital ichthyosiform erythroderma10.0ALOXE3, ALOX12B
43toxic encephalopathy10.0NGF, BDNF
44asthma10.0NGFR, NGF, IKBKAP
45sensory peripheral neuropathy10.0NGF, NTRK1, BDNF
46hepatocellular carcinoma10.0BDNF, MAPK1
47rett syndrome10.0NGF, NTRK1, BDNF
48neuroepithelioma10.0MAPK10, MAPK1, NGF
49prion disease10.0BDNF, NTRK1, NGF
50allergic asthma10.0NGF, NTRK1, BDNF

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to anhidrosis

Clinical Features for Anhidrosis

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46OMIM
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Clinical features from OMIM:

206600

Drugs & Therapeutics for Anhidrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anhidrosis

Drug clinical trials:

Search ClinicalTrials for Anhidrosis

Search NIH Clinical Center for Anhidrosis

Search CenterWatch for Anhidrosis

Genetic Tests for Anhidrosis

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Anatomical Context for Anhidrosis

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32MalaCards
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MalaCards organs/tissues related to Anhidrosis:

32
Skin, Testes, Bone, Spinal cord, Lung, T cells

Animal Models for Anhidrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Anhidrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6ALOXE3, ALOX12B, IKBKAP, BDNF
2MP:00030128.3BDNF, NTRK1, NGF, ALOX12B, ALOXE3
3MP:00053698.2NTRK1, MAPK1, NGFR, NGF, GLA, IKBKAP
4MP:00053857.5MAPK10, MAPK1, NGFR, NGF, GLA, IKBKAP
5MP:00053787.3NTRK1, MAPK1, NGFR, NGF, IKBKAP, ALOXE3
6MP:00036317.0BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
7MP:00053866.9BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
8MP:00107686.7BDNF, PKLR, NTRK1, MAPK1, NGFR, NGF
9MP:00053766.4BDNF, PKLR, MAPK10, MAPK1, NGFR, NGF

Publications for Anhidrosis

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Sources:
50PubMed
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Articles related to Anhidrosis:

(show top 50)    (show all 246)
idTitleAuthorsYear
1
Old fractures in two patients with congenital insensitivity to pain with anhidrosis: radiological findings. (23478071)
2013
2
Investigation of antimuscarinic receptor autoantibodies in patients with acquired idiopathic generalized anhidrosis. (24334576)
2013
3
Holocord syrinx presenting as hemi anhidrosis. (23741667)
2013
4
Congenital insensitivity to pain with anhidrosis presenting with palmoplantar keratoderma. (22957891)
2013
5
Severe complications in wound healing and fracture treatment in two brothers with congenital insensitivity to pain with anhidrosis. (22814739)
2013
6
Seeing is not always believing: congenital insensitivity to pain with anhidrosis mimicking leprosy. (24290131)
2013
7
Nerve growth factor and the physiology ofA pain: lessons from congenital insensitivity to pain with anhidrosis. (22882139)
2012
8
Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis. (22653642)
2012
9
Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation. (22032467)
2012
10
Congenital insensitivity to pain with anhidrosis. (23248706)
2012
11
Anhidrosis after anterior retroperitoneal approach for L4-L5 artificial disc replacement. (21570302)
2011
12
A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis. (21708027)
2011
13
Syringolymphoid hyperplasia with alopecia and anhidrosis in a 12-year-old boy: a case report from rural south India. (21623775)
2011
14
Neurotrophic keratitis and congenital insensitivity to pain with anhidrosis--a case report with 10-year follow-up. (20847675)
2011
15
Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. (21233059)
2011
16
Novel neurotrophic tyrosine kinase receptor type 1 gene mutation associated with congenital insensitivity to pain with anhidrosis. (20647579)
2010
17
Nerve growth factor, interoception, and sympathetic neuron: lesson from congenital insensitivity to pain with anhidrosis. (19201660)
2009
18
Humoral immunodeficiency in congenital insensitivity to pain with anhidrosis. (19089473)
2009
19
Unilateral hyperhidrosis with accompanying contralateral anhidrosis. (19222501)
2009
20
Traumatic lesions from congenital insensitivity to pain with anhidrosis in a pediatric patient: dental management. (19754700)
2009
21
Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. (18077166)
2008
22
A case of herpes zoster in a child with congenital insensitivity to pain with anhidrosis. (17381455)
2007
23
Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosis. (16279365)
2005
24
Thermogram of idiopathic segmental anhidrosis. (15985577)
2005
25
Anti-apoptotic effect of nerve growth factor is lost in congenital insensitivity to pain with anhidrosis (CIPA) B lymphocytes. (15114061)
2004
26
The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis. (15078381)
2004
27
Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (12102460)
2002
28
Congenital insensitivity to pain with anhidrosis (CIPA): the spectrum of radiological findings. (11685437)
2001
29
Congenital insensitivity to pain with anhidrosis. (11483399)
2001
30
Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. (11159935)
2001
31
Absent innervation of skin and sweat glands in congenital insensitivity to pain with anhidrosis. (10964070)
2000
32
Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. (10330344)
1999
33
Oral manifestations of hereditary sensory and autonomic neuropathy type IV. Congenital insensitivity to pain with anhidrosis. (9798226)
1998
34
Congenital insensitivity to pain with anhidrosis: lack of eccrine sweat gland innervation confirmed. (9620018)
1998
35
Congenital insensitivity to pain with anhidrosis. A case report. (9651783)
1998
36
Two unusual cases of anhidrosis. (7805410)
1994
37
Congenital sensory neuropathy with anhidrosis (hereditary sensory neuropathy type IV). (1284106)
1992
38
Spelling of anhidrosis. (2913819)
1989
39
Congenital sensory neuropathy with anhidrosis. (3281596)
1988
40
Bilateral Adie's tonic pupil with anhidrosis and hyperthermia. (6696660)
1984
41
Autonomic neuropathy in the skin: a histological study of the sympathetic nerve fibres in diabetic anhidrosis. (7060854)
1982
42
Pruritus and acquired anhidrosis. Two unusual cases. (5822371)
1969
43
Patchy alopecia, anhidrosis, eccrine gland wall hypertrophy and vasculitis. (5775232)
1969
44
Percutaneous steroid absorption in anhidrosis. (5361579)
1969
45
Adhesive tape anhidrosis. (5358104)
1969
46
Eccrine anhidrosis due to glutaraldehyde, formaldehyde, and iontophoresis. (5361575)
1969
47
Congenital sensory neuropathy with anhidrosis. (4171106)
1968
48
Diabetic anhidrosis. (5922894)
1966
49
Acquired generalized anhidrosis. (4285915)
1966
50
Anhidrosis following intravenous bacterial pyrogen. (13796464)
1960

Genetic Variations for Anhidrosis

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Expression for genes affiliated with Anhidrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anhidrosis

Search GEO for disease gene expression data for Anhidrosis.

Pathways for genes affiliated with Anhidrosis

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 51QIAGEN, 49PharmGKB, 59Tocris Bioscience, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems
See all sources

Pathways related to Anhidrosis according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2NTRK1
2
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10.2NGF
3
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9.9NTRK1, NGF
4
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9.9NTRK1, NGF
59.8NGFR, NGF
6
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9.8NGFR, NGF
7
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9.8NGF, NGFR
89.8NGFR, NGF
9
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9.8ALOX12B, ALOXE3
10
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9.7BDNF
11
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9.4NGF, MAPK1, NTRK1
12
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9.4NTRK1, MAPK1, NGF
13
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9.4NGF, MAPK1, NTRK1
14
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9.4NTRK1, MAPK1, NGF
159.3MAPK1, MAPK10
16
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9.3MAPK1, MAPK10
17
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9.3MAPK1, MAPK10
18
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9.2NGFR, MAPK10, NTRK1
19
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9.2NGFR, MAPK10, NTRK1
209.1MAPK1, BDNF
21
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9.0MAPK1, MAPK10, PKLR
229.0NGFR, NTRK1, BDNF
23
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9.0NGF, NGFR, MAPK1, NTRK1
24
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8.9BDNF, NGFR, NGF
25
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8.9MAPK10, MAPK1, NGFR
268.9BDNF, NTRK1, MAPK1
27
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8.8NGF, MAPK1, MAPK10, NTRK1
288.7BDNF, MAPK1, NGFR
298.7NGF, NGFR, NTRK1, BDNF
30
Hide members
8.7NTRK1, MAPK10, MAPK1, NGFR
31
Hide members
8.5BDNF, MAPK10, MAPK1
32
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8.5BDNF, NTRK1, MAPK1, NGFR
33
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8.5NGFR, MAPK1, NTRK1, BDNF
34
Hide members
8.5BDNF, NTRK1, MAPK1, NGFR
358.3BDNF, MAPK10, NGFR, NGF
36
Hide members
8.2BDNF, NTRK1, MAPK10, MAPK1
37
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8.2BDNF, PKLR, MAPK10, MAPK1
388.2BDNF, NTRK1, MAPK1, NGFR, NGF
39
Hide members
8.1BDNF, MAPK10, MAPK1, NGFR
40
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7.9NGF, MAPK1, MAPK10, NTRK1, BDNF
41
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7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
42
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7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
43
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
44
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
45
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
46
Hide members
7.5NGF, NGFR, MAPK1, MAPK10, NTRK1, BDNF
477.5NGF, NGFR, MAPK1, MAPK10, NTRK1, BDNF

Compounds for genes affiliated with Anhidrosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Anhidrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1forskolin44 49 1112.4NGFR
2serine4410.3GLA, PKLR
3cipa4410.2NTRK1, NGF
412(r)-hpete44 2411.1ALOXE3, ALOX12B
5ag 879449.7NTRK1, MAPK10, NGF
6estradiol valerate449.7NGF, NGFR
7gnrh449.6BDNF, NTRK1
8ganglioside449.6GLA, NGF, NGFR, NTRK1
9pyridinylimidazole449.5MAPK10, MAPK1
101,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene449.5MAPK10, MAPK1
11gw-5074449.4MAPK10, MAPK1
12olomoucine44 1110.4MAPK10, MAPK1, NGF
13thapsigargin44 5910.3MAPK10, BDNF
14hcec449.2BDNF, MAPK1, NGF
15c2ceramide449.2NTRK1, MAPK10, MAPK1, NGF
16rasagiline44 1110.1BDNF, MAPK10, NGF
17tlqp 21599.1NGFR, NTRK1, BDNF, NGF
18ana 12599.1NGF, NGFR, NTRK1, BDNF
19nmda44 2810.1NGF, MAPK10, BDNF
20bdnf (human)599.1BDNF, NGF, NGFR, NTRK1
21gnf 5837599.1NGF, NGFR, NTRK1, BDNF
227,8-dihydroxyflavone44 5910.1BDNF, NTRK1, NGFR, NGF
23capsaicin44 2810.1NGF, NTRK1, BDNF
24phorbol449.0NTRK1, MAPK10, MAPK1, NGFR
25choline44 11 2411.0BDNF, NTRK1, NGFR, NGF
26phenylalanine449.0NGFR, PKLR, BDNF
27bisindolylmaleimide448.8MAPK1, MAPK10, BDNF
28phosphotyrosine448.8NTRK1, MAPK10, MAPK1, NGFR, NGF
2912-o-tetradecanoylphorbol 13-acetate448.8NTRK1, MAPK10, MAPK1, NGFR, NGF
30anisomycin44 119.6NGF, MAPK1, MAPK10, BDNF
31matrigel448.6BDNF, NTRK1, MAPK1, NGFR, NGF
32ceramide448.5NTRK1, MAPK10, MAPK1, NGFR, NGF, GLA
33acetylcholine44 49 28 11 2412.4NGF, NGFR, MAPK10, NTRK1, BDNF
34pd 98,059448.3NGF, MAPK1, MAPK10, NTRK1, BDNF
35ly294002448.3BDNF, NTRK1, MAPK10, MAPK1, NGF
36cyclic amp44 249.3NGF, NGFR, MAPK10, NTRK1, BDNF
37adenylate448.2NGF, MAPK1, MAPK10, NTRK1, BDNF
38glutamate448.2BDNF, NTRK1, MAPK1, NGFR, NGF, GLA
39cycloheximide448.1BDNF, NTRK1, MAPK10, MAPK1, NGF
40thymidine44 249.1BDNF, MAPK10, MAPK1, NGFR, NGF
41arachidonic acid44 28 11 2411.1BDNF, NTRK1, MAPK10, NGFR, ALOX12B, ALOXE3
42k252a448.0NGF, NGFR, MAPK1, MAPK10, NTRK1, BDNF
43threonine448.0NTRK1, MAPK10, MAPK1, NGFR, NGF, GLA
44wortmannin448.0BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
45phosphoinositide448.0BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
46vegf447.9BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
47phosphatidylinositol447.9BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
48retinoic acid44 248.8BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
49h2o2447.6BDNF, NTRK1, MAPK10, MAPK1, ALOX12B
50tyrosine447.2BDNF, PKLR, NTRK1, MAPK10, MAPK1, NGFR

GO Terms for genes affiliated with Anhidrosis

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Sources:
16Gene Ontology
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Cellular components related to Anhidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:0057689.5NGF, NGFR, NTRK1

Biological processes related to Anhidrosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1establishment of skin barrierGO:06143610.1ALOX12B, ALOXE3
2hepoxilin biosynthetic processGO:05112210.1ALOXE3, ALOX12B
3response to electrical stimulusGO:05160210.0NGF, NTRK1
4linoleic acid metabolic processGO:04365110.0ALOX12B, ALOXE3
5regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432819.9NGFR, NGF
6lipoxygenase pathwayGO:0193729.9ALOXE3, ALOX12B
7positive regulation of axonogenesisGO:0507729.8NGF, NGFR
8regulation of axonogenesisGO:0507709.8NGF, NGFR
9sphingolipid metabolic processGO:0066659.7GLA, ALOX12B, ALOXE3
10activation of MAPKK activityGO:0001869.7NGF, MAPK1, NTRK1
11mechanoreceptor differentiationGO:0424909.7NTRK1, BDNF
12Ras protein signal transductionGO:0072659.7NTRK1, MAPK1, NGF
13ceramide biosynthetic processGO:0465139.7ALOX12B, ALOXE3
14response to radiationGO:0093149.6NGF, NTRK1
15sensory perception of painGO:0192339.6ALOXE3, NGF, MAPK1
16nerve developmentGO:0216759.4BDNF, NGFR
17negative regulation of neuron apoptotic processGO:0435249.3NGF, NTRK1, BDNF
18neurotrophin TRK receptor signaling pathwayGO:0480119.2NGF, NGFR, MAPK1, NTRK1
19axon guidanceGO:0074118.7BDNF, NTRK1, MAPK1, NGFR

Molecular functions related to Anhidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenGO:0167029.8ALOXE3, ALOX12B
2nerve growth factor bindingGO:0484069.5NGFR, NTRK1

Products for genes affiliated with Anhidrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anhidrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet