Aliases & Classifications for Anhidrosis

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Aliases & Descriptions for Anhidrosis:

Name: Anhidrosis 11 13 48 66
Absence of Sweating 11
 
Adiaphoresis 11

Classifications:



External Ids:

Disease Ontology11 DOID:11156
ICD1028 L74.4
ICD9CM30 705.0
MeSH37 D007007
NCIt43 C34385

Summaries for Anhidrosis

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Wikipedia:69 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards based summary: Anhidrosis, also known as absence of sweating, is related to pyruvate kinase deficiency and insensitivity to pain, congenital, with anhidrosis, and has symptoms including night sweats, cold sweat and increased sweating. An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways are Activation of TRKA receptors and 14-3-3 and Regulation of BAD Activity. Affiliated tissues include skin, testes and t cells, and related mouse phenotypes are integument and vision/eye.

Related Diseases for Anhidrosis

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Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1pyruvate kinase deficiency29.6NTRK1, PKLR
2insensitivity to pain, congenital, with anhidrosis12.3
3anhidrosis, isolated, with normal sweat glands12.1
4harlequin syndrome11.4
5van den bosch syndrome10.9
6hypohidrosis10.9
7horner's syndrome10.5
8neuropathy10.4
9neuropathy, hereditary sensory and autonomic, type v10.3NGF, NTRK1
10pharynx carcinoma in situ10.3NGF, NTRK1
11c5 deficiency10.2NGF, NTRK1
12autonomic neuropathy10.1
13epidermolysis bullosa simplex superficialis10.1NGF, NTRK1
14diffuse large b-cell lymphoma10.1NGF, NTRK1
15alopecia10.0
16ectodermal dysplasia10.0
17miliaria10.0
18rumination disorder10.0NGF, NTRK1
19cholinergic urticaria9.9
20urticaria9.9
21dermatitis9.9
22pseudoainhum9.9NGF, NGFR
23multiple system atrophy9.8
24leprosy9.8
25hereditary sensory neuropathy9.8
26ptosis9.8
27sialadenitis9.8
28impotence9.8
29vasculitis9.8
30headache9.8
31postural hypotension9.8
32papillary serous adenocarcinoma9.8NGF, NTRK1
33anal colloid adenocarcinoma9.8NGFR, NTRK1
34ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive9.8
35ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant9.8
36ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant9.8
37ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive9.8
38ichthyosis, congenital, autosomal recessive 4a9.8
39ichthyosis, congenital, autosomal recessive 69.8
40ichthyosis, congenital, autosomal recessive 109.8
41ichthyosis, congenital, autosomal recessive 89.8
42ichthyosis, congenital, autosomal recessive 119.8
43ichthyosis, congenital, autosomal recessive 79.8
44immunodeficiency 99.8
45ichthyosis, congenital, autosomal recessive 19.8
46ichthyosis, congenital, autosomal recessive 99.8
47ichthyosis, congenital, autosomal recessive 29.8
48ichthyosis, congenital, autosomal recessive 39.8
49ichthyosis, congenital, autosomal recessive 59.8
50ectodermal dysplasia 1, hypohidrotic, x-linked9.8

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to anhidrosis

Symptoms for Anhidrosis

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UMLS symptoms related to Anhidrosis:


night sweats, cold sweat, increased sweating

Drugs & Therapeutics for Anhidrosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and AnhidrosisWithdrawnNCT02624310Phase 2

Search NIH Clinical Center for Anhidrosis

Genetic Tests for Anhidrosis

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Anatomical Context for Anhidrosis

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MalaCards organs/tissues related to Anhidrosis:

34
Skin, Testes, T cells, Neutrophil, Bone, Lung, Spinal cord

Animal Models for Anhidrosis or affiliated genes

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MGI Mouse Phenotypes related to Anhidrosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0IKBKG, ITPR2, NGF, NGFR, NTRK1, ORAI1
2MP:00053917.9CHRM3, NGF, NGFR, NTRK1, ORAI1
3MP:00028737.8IKBKG, ITPR2, NGF, NGFR, NTRK1, PKLR
4MP:00053867.5CHRM3, IKBKG, ITPR2, NGF, NGFR, NTRK1
5MP:00107687.1IKBKG, ITPR2, NGF, NGFR, NTRK1, ORAI1
6MP:00053786.9CHRM3, IKBKG, ITPR2, NGF, NGFR, NTRK1
7MP:00053766.7CHRM3, IKBKG, ITPR2, NGF, NGFR, ORAI1

Publications for Anhidrosis

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Articles related to Anhidrosis:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
Harlequin syndrome with contralateral anhidrosis after an upper chest gunshot wound. (27535737)
2016
2
Raeder's Paratrigeminal Syndrome: Headache and Horner's Lacking Anhidrosis. (26902244)
2016
3
Purple hands in multiple system atrophy: Global anhidrosis with preserved acral sweating. (27298449)
2016
4
Unilateral anhidrosis: A rare complication of thoracic epidural analgesia. (26612960)
2016
5
Anesthetic Management of Patients with Congenital Insensitivity to Pain with Anhidrosis: A Retrospective Analysis of 358 Procedures Performed Under General Anesthesia. (26484462)
2015
6
Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis. (25060903)
2014
7
A case of congenital insensitivity to pain with anhidrosis. (26078659)
2014
8
Investigation of antimuscarinic receptor autoantibodies in patients with acquired idiopathic generalized anhidrosis. (24334576)
2013
9
Oral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosis. (23799134)
2013
10
Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis. (22653642)
2012
11
Right ptosis, anhidrosis, and miosis developed in a 49-year-old man with chronic dry cough for 2 months. (22796847)
2012
12
Congenital Insensitivity to Pain with Anhidrosis (HSAN Type IV), Extremely Rare Syndrome that Can Be Easily Missed by Bone and Joint Surgeons: A Case Report. (23429452)
2012
13
Syringolymphoid hyperplasia with alopecia and anhidrosis in a 12-year-old boy: a case report from rural south India. (21623775)
2011
14
Evaluation of nonnociceptive sensation in patients with congenital insensitivity to pain with anhidrosis. (20013280)
2010
15
Risk of aspiration during anesthesia in patients with congenital insensitivity to pain with anhidrosis: case reports and review of the literature. (20632040)
2010
16
Poikilodermia, anhidrosis, hairless body, neurogenic muscle atrophy, and recurrent hematuria: a new syndrome? (20179583)
2010
17
Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction? (18361470)
2008
18
Dental management of oral self-mutilation in neurological patients: a case of congenital insensitivity to pain with anhidrosis. (18830173)
2008
19
Spinal anesthesia in a patient with congenital insensitivity to pain with anhidrosis. (17513658)
2007
20
Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosis. (16279365)
2005
21
Congenital insensitivity to pain with Anhidrosis (NTRK1 mutation) and early onset renal disease: clinical report on three sibs with a 25-year follow-up in one of them. (16138253)
2005
22
Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission. (15505168)
2004
23
Intrasinus wood foreign body causing orbital cellulitis in congenital insensitivity to pain with anhidrosis syndrome. (14752319)
2004
24
Desflurane used in a patient with congenital insensitivity to pain with anhidrosis during septic shock. (15366409)
2004
25
Congenital insensitivity of pain with anhidrosis. (12619965)
2003
26
Post-herpetic neuralgia in a patient with congenital insensitivity to pain and anhidrosis. (14566502)
2002
27
Congenital insensitivity to pain with anhidrosis: an NGF/TrkA-related disorder. (11241480)
2001
28
Congenital insensitivity to pain with anhidrosis. (11483399)
2001
29
Congenital insensitivity to pain with anhidrosis: ocular and systemic manifestations. (10088743)
1999
30
A female patient with the Rothmund-Thomson syndrome associated with anhidrosis and severe infections of the respiratory tract. (9568421)
1998
31
Oral manifestations of hereditary sensory and autonomic neuropathy type IV. Congenital insensitivity to pain with anhidrosis. (9798226)
1998
32
Decreased CSF levels of substance P in patients with congenital sensory neuropathy with anhidrosis. (9109918)
1997
33
Possible mechanism of anhidrosis in a symptomatic female carrier of Fabry's disease: an assessment by skin sympathetic nerve activity and sympathetic skin response. (8726095)
1996
34
Unilateral loss of facial flushing and sweating with contralateral anhidrosis: harlequin syndrome or Adie's syndrome? (8292878)
1993
35
Tonic pupil, areflexia, and segmental anhidrosis: two additional cases of Ross syndrome and review of the literature. (1597691)
1992
36
Familial generalized anhidrosis. (2401613)
1990
37
Idiopathic acquired generalized anhidrosis: electron-microscopic and immunohistochemical studies and analysis of lectin-binding pattern of the cell membrane. (2721803)
1989
38
Hereditary sensory neuropathy with anhidrosis. A new family with a study of the sensory conduction velocity. (92176)
1978
39
Congenital sensory neuropathy with anhidrosis: a case report. (1250661)
1976
40
Pruritus and acquired anhidrosis. Two unusual cases. (5822371)
1969
41
Primary anhidrosis partialis. A case report. (5791208)
1969
42
Congenital sensory neuropathy with anhidrosis. (4171106)
1968
43
Diabetic anhidrosis. (5922894)
1966
44
Anhidrosis following intravenous bacterial pyrogen. (13796464)
1960
45
Anhidrotic ectodermal dysplasia: use of the silver nitrate plate to detect anhidrosis. (13611610)
1959
46
A form of ectodermal dysplasia; hypotrichosis with anhidrosis and anodontia]. (13023176)
1952
47
Orthostatic hypotension, anhidrosis, and impotence. (14936198)
1952
48
Clinical effects of exposure to heat and sunlight. II. Heat hyperpyrexia and thermogenic anhidrosis. (14935259)
1952
49
Unilateral frontal anhidrosis and miosis occurring after petrous apicectomy, Ramadier technic; report of a case. (18111208)
1948
50
A study of miliaria rubra, tropical anhidrosis and anhidrotic asthenia. (20242508)
1947

Variations for Anhidrosis

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Expression for genes affiliated with Anhidrosis

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Search GEO for disease gene expression data for Anhidrosis.

Pathways for genes affiliated with Anhidrosis

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Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7NGF, NTRK1
29.5NGF, NGFR
39.3ITPR2, NGF, NTRK1
49.3ITPR2, ORAI1
59.2NGF, NGFR, NTRK1
69.2NGF, NGFR, NTRK1
79.2NGF, NGFR, NTRK1
8
Show member pathways
9.2NGF, NGFR, NTRK1
9
Show member pathways
9.2NGF, NGFR, NTRK1
109.2IKBKG, ORAI1
11
Show member pathways
9.2ITPR2, NGF, NGFR
12
Show member pathways
9.2IKBKG, NGFR, NTRK1
13
Show member pathways
9.1IKBKG, NGF, NGFR
149.1IKBKG, NGF, NGFR
15
Show member pathways
9.1IKBKG, NGF, NGFR
16
Show member pathways
9.0CHRM3, ITPR2, PKLR
17
Show member pathways
8.9IKBKG, ITPR2, NGF, NTRK1
18
Show member pathways
8.9IKBKG, ITPR2, NGF, NTRK1
19
Show member pathways
8.8ITPR2, NGF, NGFR, NTRK1
208.8CHRM3, ITPR2, ORAI1
21
Show member pathways
8.8CHRM3, ITPR2, ORAI1
22
Show member pathways
8.7IKBKG, NGF, NGFR, NTRK1
23
Show member pathways
8.7IKBKG, ITPR2, NGF, NGFR
24
Show member pathways
8.7IKBKG, ITPR2, NGF, NGFR
25
Show member pathways
8.4IKBKG, ITPR2, NGF, NGFR, NTRK1

GO Terms for genes affiliated with Anhidrosis

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Cellular components related to Anhidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:00057689.2NGF, NGFR, NTRK1

Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:000018610.0NGF, NTRK1
2regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004328110.0NGF, NGFR
3positive regulation of axonogenesisGO:005077210.0NGF, NGFR
4negative regulation of neuron deathGO:19012159.9IKBKG, NTRK1
5positive regulation of Ras protein signal transductionGO:00465799.9NGF, NTRK1
6sensory perception of painGO:00192339.7NGFR, NTRK1
7negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.5NGF, NGFR
8neurotrophin TRK receptor signaling pathwayGO:00480119.4NGF, NGFR, NTRK1
9positive regulation of synaptic transmission, glutamatergicGO:00519689.3NGFR, NTRK1
10negative regulation of neuron apoptotic processGO:00435249.1NGF, NGFR, NTRK1

Molecular functions related to Anhidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nerve growth factor bindingGO:00484069.6NGFR, NTRK1

Sources for Anhidrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet