Anhidrosis malady

Wikipedia: Anhidrosis means lack of sweating. It is also known by a number of other names including...⁴⁴ more...

MalaCards: Anhidrosis, also known as absence of sweating (finding), is related to insensitivity to pain and pyruvate kinase deficiency. An important gene associated with Anhidrosis is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are PAK Pathway and Prostaglandin 2 biosynthesis and metabolism FM. The compounds ly294002 and cipa have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are taste/olfaction and integument.

Aliases & Descriptions:

anhidrosis 6 8 32 43 absence of sweating (finding) 6

anhidrosis (disorder) 6 adiaphoresis 6

Diseases related to anhidrosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 101)

id	Related Disease	Score	Top Affiliating Genes
1	insensitivity to pain	31.7	NGFR, NGF, PKLR, NTRK1, MAPK1, MAPK10
2	pyruvate kinase deficiency	28.0	PKLR, NTRK1
3	autonomic neuropathy	26.2	NGFR, NGF, NTRK1, IKBKAP, CCT5
4	neuropathy	24.1	NGFR, NGF, NTRK1, GLA, IKBKAP, CCT5
5	askin's tumor	13.4	NGF, NTRK1
6	congenital ichthyosiform erythroderma	13.3	ALOXE3, ALOX12B
7	neuroaxonal dystrophy	13.2	NGF, NTRK1
8	autosomal recessive congenital ichthyosis	13.1	ALOX12B, ALOXE3
9	olfactory neuroblastoma	13.0	NGFR, NTRK1
10	cannabis abuse	13.0	BDNF, NGF
11	ewing's family of tumors	13.0	NGF, NGFR
12	anxiety-related personality traits	13.0	BDNF, NGF
13	hereditary sensory and autonomic neuropathy type v	13.0	NTRK1, NGF, NGFR
14	ganglioneuroma	12.9	NGFR, NGF, NTRK1
15	hypohidrosis	12.9	IKBKAP, GLA, NTRK1
16	hereditary sensory neuropathy	12.9	NGF, NTRK1, IKBKAP
17	adenomyosis	12.9	NTRK1, NGF, NGFR
18	ependymoma	12.8	NGFR, NGF, NTRK1
19	sensory peripheral neuropathy	12.8	BDNF, NTRK1, NGF
20	rett syndrome	12.7	NGF, NTRK1, BDNF
21	prion disease	12.7	BDNF, NTRK1, NGF
22	botulism	12.7	IKBKAP, NGF
23	allergic asthma	12.6	BDNF, NTRK1, NGF
24	prolactinoma	12.6	NGFR, NGF, MAPK1
25	dry eye syndrome	12.6	BDNF, NGF
26	hirschsprung's disease	12.6	NGFR, NTRK1, IKBKAP
27	riley-day syndrome	12.6	BDNF, IKBKAP, NTRK1
28	drug addiction	12.6	BDNF, MAPK1
29	cerebral artery occlusion	12.5	BDNF, MAPK1, NGF
30	huntington's disease	12.5	BDNF, NGF, NGFR
31	diabetic neuropathy	12.4	NGFR, NGF, NTRK1, MAPK1
32	tonsillitis	12.4	BDNF, ALOX12B, NTRK1, NGF
33	adenoid cystic carcinoma	12.4	MAPK1, NTRK1, NGF
34	toxic encephalopathy	12.4	NGF, MAPK1, BDNF
35	neuroma	12.4	MAPK10, NGF, NGFR
36	eating disorder	12.3	NGFR, NGF, NTRK1, BDNF
37	atopic dermatitis	12.3	NGFR, NGF, BDNF
38	polyneuropathy	12.3	NGF, IKBKAP, MAPK1
39	neuroepithelioma	12.3	NGF, MAPK1, MAPK10
40	temporal lobe epilepsy	12.3	NGFR, NGF, NTRK1, BDNF
41	papillary thyroid carcinoma	12.3	NTRK1, MAPK1, MAPK10
42	parkinson's disease	12.3	NGFR, NGF, NTRK1, BDNF
43	dysautonomia	12.3	NGF, NTRK1, IKBKAP, BDNF
44	attention deficit hyperactivity disorder	12.2	NGFR, NGF, BDNF
45	epithelial ovarian cancer	12.2	NGF, NTRK1, ALOXE3, ALOX12B, MAPK1
46	traumatic brain injury	12.2	BDNF, MAPK1, NGF
47	cerebral primitive neuroectodermal tumor	12.1	NGFR, NGF, NTRK1, MAPK10
48	neuroectodermal tumors	12.1	NGFR, NGF, NTRK1, MAPK10
49	bronchiolitis	12.1	NGFR, NGF, IKBKAP, MAPK1
50	allergic rhinitis	12.0	NGFR, NGF, MAPK1, BDNF

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to anhidrosis:

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MGI Mouse Phenotypes related to anhidrosis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	8.6	NGFR, MAPK1, BDNF
2	integument phenotype	MP:0010771	7.9	BDNF, IKBKAP, ALOX12B, NTRK1, NGF, NGFR
3	behavior/neurological phenotype	MP:0005386	7.2	BDNF, MAPK10, MAPK1, GLA, NTRK1, NGF

Articles related to anhidrosis:

(show all 31)

id	Title	Authors	Year	Affiliating Genes
1	Skoura - a genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene. (19250380)	Suriu C.... Falik-Zaccai T.C.	2009	NTRK1
2	Clinical and genetic analysis of Korean patients with congenital insensitivity to pain with anhidrosis. (19618435)	Lee S.T.... Ki C.S.	2009	NTRK1
3	Nerve growth factor, interoception, and sympathetic neuron: lesson from congenital insensitivity to pain with anhidrosis. (19201660)	Indo Y.	2009	NTRK1, NGF
4	Humoral immunodeficiency in congenital insensitivity to pain with anhidrosis. (19089473)	Kilic S.S.... Timmerman V.	2009	NTRK1
5	Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor. (18955016)	Beigelman A.... Levy R.	2009	NTRK1, MAPK1, MAPK10
6	Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. (18077166)	Huehne K.... Rautenstrauss B.	2008	NTRK1
7	Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosis. (16279365)	Schreiber R.... Hershkovitz E.	2005	NTRK1, NGF
8	Congenital insensitivity to pain with Anhidrosis (NTRK1 mutation) and early onset renal disease: clinical report on three sibs with a 25-year follow-up in one of them. (16138253)	Barone R.... Pavone P.	2005	NTRK1, NGF
9	Clinical and genetic aspects of congenital insensitivity to pain with anhidrosis (15999564)	Schwarzkopf R.... Gorzak Y.	2005	NTRK1, NGF
10	Anti-apoptotic effect of nerve growth factor is lost in congenital insensitivity to pain with anhidrosis (CIPA) B lymphocytes. (15114061)	Sato Y.... Eguchi M.	2004	NTRK1, NGF
11	The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis. (15078381)	Rozentsveig V.... Gurman G.M.	2004	NTRK1
12	A novel lymphocyte signaling defect: trk A mutation in the syndrome of congenital insensitivity to pain and anhidrosis (CIPA). (15163901)	Melamed I.... Gelfand E.W.	2004	NTRK1, NGFR
13	Congenital insensitivity to pain with anhidrosis in Taiwan: a morphometric and genetic study. (15159601)	Guo Y.C.... Lin K.P.	2004	NTRK1
14	An infant with primary tooth loss and palmar hyperkeratosis: a novel mutation in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis. (12949319)	Bonkowsky J.L.... Swoboda K.J.	2003	NTRK1
15	Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (12102460)	Indo Y.	2002	NTRK1
16	The M581V mutation, associated with a mild form of congenital insensitivity to pain with anhidrosis, causes partial inactivation of the NTRK1 receptor. (12406349)	Miranda C.... Greco A.	2002	NTRK1
17	Novel pathogenic mechanisms of congenital insensitivity to pain with anhidrosis genetic disorder unveiled by functional analysis of neurotrophic tyrosine receptor kinase type 1/nerve growth factor receptor mutations. (11719521)	Miranda C.... Greco A.	2002	NTRK1
18	Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (11748840)	Indo Y.	2001	NTRK1, NGF
19	Two novel mutant alleles of the gene encoding neurotrophic tyrosine kinase receptor type 1 (NTRK1) in a patient with congenital insensitivity to pain with anhidrosis: a splice junction mutation in intron 5 and cluster of four mutations in exon 15. (11139246)	Bodzioch M.... Schmitz G.	2001	NTRK1
20	Neurophysiologic studies in congenital insensitivity to pain with anhidrosis. (11744315)	Shorer Z.... Levy J.	2001	NTRK1
21	Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency. (11668614)	Indo Y.... Matsuda I.	2001	NTRK1, PKLR
22	Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. (11159935)	Mardy S.... Indo Y.	2001	NTRK1, NGF
23	Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families. (10982191)	Miura Y.... Indo Y.	2000	NTRK1
24	Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli- Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. (10861667)	Shatzky S.... Parvari R.	2000	NTRK1
25	The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor. (10567924)	Greco A.... Pierotti M.A.	2000	NTRK1, NGF
26	Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with congenital insensitivity to pain with anhidrosis. (11071380)	Miura Y.... Indo Y.	2000	NTRK1
27	A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis. (10233776)	Yotsumoto S.... Kanzaki T.	1999	NTRK1
28	A novel NTRK1 mutation associated with congenital insensitivity to pain with anhidrosis. (10090906)	Greco A.... Pierotti M.A.	1999	NTRK1
29	Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. (10330344)	Mardy S.... Indo Y.	1999	NTRK1
30	Possible mechanism of anhidrosis in a symptomatic female carrier of Fabry's disease: an assessment by skin sympathetic nerve activity and sympathetic skin response. (8726095)	Yamamoto K.... Mano T.	1996	GLA
31	Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. (8696348)	Indo Y.... Matsuda I.	1996	NTRK1, NGF

Genes related to anhidrosis according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.1	Summaries, Publications
2	GLA	galactosidase, alpha	11.0	Publications
3	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
4	ALOX12B	arachidonate 12-lipoxygenase, 12R type	11.0
5	PKLR	pyruvate kinase, liver and RBC	11.0	Publications
6	ALOXE3	arachidonate lipoxygenase 3	11.0
7	NGFR	nerve growth factor receptor	11.0	Publications
8	CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	11.0
9	IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	11.0
10	BDNF	brain-derived neurotrophic factor	11.0
11	MAPK10	mitogen-activated protein kinase 10	11.0	Publications
12	MAPK1	mitogen-activated protein kinase 1	11.0	Publications

Pathways related to anhidrosis according to GeneDecks:

(show all 47)

id	Pathway	Score	Top Affiliating Genes
1	PAK Pathway36	10.0	MAPK10
2	Prostaglandin 2 biosynthesis and metabolism FM41	9.8	ALOXE3, ALOX12B
3	Prostaglandin 2 biosynthesis and metabolism FM10	9.8	ALOXE3, ALOX12B
4	NGF Pathway36	9.7	MAPK1, NTRK1, NGFR
5	Molecular Mechanisms of Cancer36	9.6	MAPK1, BDNF
6	Ras Pathway36	9.5	MAPK1, MAPK10
7	Guidance Cues and Growth Cone Motility36	9.5	BDNF, NTRK1, NGFR
8	Apoptotic Pathways in Synovial Fibroblasts36	9.4	BDNF, NTRK1, NGFR
9	p53 Mediated Apoptosis36	9.3	NGFR, NTRK1, BDNF
10	Development MAG-dependent inhibition of neurite outgrowth10	9.3	BDNF, NTRK1, NGF, NGFR
11	Development_MAG-dependent inhibition of neurite outgrowth41	9.3	NGFR, NGF, NTRK1, BDNF
12	JNK Pathway36	9.3	MAPK10, NTRK1, NGFR
13	TRKA Signaling36	9.2	NTRK1, MAPK1, MAPK10
14	IL-2 Gene Expression in Activated and Quiescent T-Cells36	9.2	MAPK10, MAPK1
15	Type II diabetes mellitus20	9.2	MAPK10, MAPK1, PKLR
16	TLR-TRIF Pathway36	9.1	MAPK10, MAPK1
17	PPAR Pathway36	9.1	BDNF, MAPK1, NTRK1, NGFR
18	eIF2 Pathway36	9.0	NGFR, NTRK1, MAPK1, BDNF
19	Rac1 Pathway36	9.0	NGFR, NTRK1, MAPK1, BDNF
20	Activation of PKC through GPCR36	9.0	BDNF, MAPK1, NTRK1, NGFR
21	CREB Pathway36	9.0	BDNF, MAPK1, NTRK1, NGFR
22	Insulin signaling pathway20	9.0	MAPK10, MAPK1, PKLR
23	PTEN Pathway36	9.0	NGFR, NTRK1, MAPK1, BDNF
24	JAK-STAT Pathway36	8.9	NGFR, NTRK1, MAPK1, BDNF
25	Phospholipase-C Pathway36	8.9	NGFR, NTRK1, MAPK1, BDNF
26	Telomerase Components in Cell Signaling36	8.9	NGFR, NTRK1, BDNF
27	14-3-3 Induced Intracellular Signaling36	8.6	BDNF, MAPK10, MAPK1, NTRK1
28	Tec Kinases Signaling36	8.6	NGFR, NTRK1, MAPK10, BDNF
29	NFAT in Immune Response36	8.6	NTRK1, MAPK1, MAPK10, BDNF
30	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	8.6	MAPK1, NTRK1, NGF, NGFR, MAPK10
31	Apoptosis and survival Role of CDK5 in neuronal death and survival10	8.6	NGFR, NGF, NTRK1, MAPK1, MAPK10
32	Estrogen Pathway36	8.6	BDNF, MAPK10, MAPK1, NTRK1
33	GPCR Pathway36	8.6	NTRK1, MAPK1, MAPK10, BDNF
34	GSK3 Signaling36	8.6	NTRK1, MAPK1, MAPK10, BDNF
35	TGF-Beta Pathway36	8.5	NGFR, MAPK1, MAPK10, BDNF
36	ILK Signaling36	8.4	NTRK1, MAPK1, MAPK10, BDNF
37	Glioma Invasiveness36	8.4	BDNF, MAPK10, MAPK1
38	MAPK Family Pathway36	8.4	BDNF, MAPK10, MAPK1, NGFR
39	MAPK signaling pathway20	8.4	BDNF, MAPK10, MAPK1, NTRK1, NGF
40	p70S6K Signaling36	8.3	NGFR, NTRK1, MAPK1, MAPK10, BDNF
41	Renin-Angiotensin Pathway36	8.3	NGFR, NTRK1, MAPK1, MAPK10, BDNF
42	Breast Cancer Regulation by Stathmin136	8.2	NGFR, NTRK1, MAPK1, MAPK10, BDNF
43	Antioxidant Action of Vitamin-C36	8.2	NGFR, NTRK1, MAPK1, MAPK10, BDNF
44	MAPK Signaling36	8.2	NGFR, NTRK1, MAPK1, MAPK10, BDNF
45	Development Neurotrophin family signaling10	8.0	BDNF, NGFR, NGF, NTRK1, MAPK1, MAPK10
46	Development_Neurotrophin family signaling41	8.0	NGFR, NGF, NTRK1, MAPK1, MAPK10, BDNF
47	Neurotrophin signaling pathway20	8.0	NGFR, NGF, NTRK1, MAPK1, MAPK10, BDNF

Compounds related to anhidrosis according to GeneDecks:

(show top 50)    (show all 78)

id	Compound	Score	Top Affiliating Genes
1	ly29400232	10.3	MAPK1
2	cipa32	10.2	NTRK1, NGF
3	12(r)-hpete32 18	11.2	ALOX12B, ALOXE3
4	ntr 36842	10.1	NGF, NGFR
5	estradiol valerate32	10.0	NGF, NGFR
6	ro 08-275042	9.9	NGFR, NGF, NTRK1
7	ganglioside32	9.9	GLA, NTRK1, NGFR
8	bdnf (human)42	9.6	NGFR, NGF, BDNF
9	cerebrolysin32	9.6	NGF, BDNF
10	ag 87932 42	10.5	NGF, NTRK1, MAPK10
11	hcec32	9.4	BDNF, MAPK1, NGF
12	pyridinylimidazole32	9.4	MAPK1, MAPK10
13	1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene32	9.4	MAPK1, MAPK10
14	gw-507432	9.4	MAPK1, MAPK10
15	capsaicin32	9.4	BDNF, NTRK1, NGF
16	glutamate32	9.3	NGFR, NTRK1, GLA, MAPK1
17	h2o232	9.2	BDNF, ALOX12B
18	olomoucine32 42 9 9	12.2	MAPK10, MAPK1, NGF
19	choline32 9 18 9	12.2	BDNF, NTRK1, NGF, NGFR
20	rasagiline32 9 9	11.1	BDNF, MAPK10, NGF
21	farnesylthiosalicylic acid32	9.1	MAPK10, MAPK1
22	gnrh32	9.0	NGF, NTRK1, MAPK1, BDNF
23	phenylalanine32	9.0	NGFR, PKLR, NTRK1, BDNF
24	c2ceramide32	9.0	NGF, NTRK1, MAPK1, MAPK10
25	phorbol32	8.8	NGFR, NTRK1, MAPK1, MAPK10
26	bisindolylmaleimide32	8.8	MAPK1, MAPK10, BDNF
27	matrigel32	8.8	NGFR, NGF, NTRK1, MAPK1, BDNF
28	anisomycin32 42 9 9	11.6	NGF, MAPK1, MAPK10, BDNF
29	phosphotyrosine32	8.6	NGFR, NGF, NTRK1, MAPK1, MAPK10
30	12-o-tetradecanoylphorbol 13-acetate32	8.6	NGFR, NGF, NTRK1, MAPK1, MAPK10
31	thapsigargin32 42	9.5	BDNF, MAPK10, MAPK1, NGF
32	acetylcholine32 9 18 9	11.4	NGFR, NGF, NTRK1, MAPK10, BDNF
33	pd 98,05932	8.3	BDNF, MAPK10, MAPK1, NTRK1, NGF
34	ceramide32	8.3	NGFR, NGF, NTRK1, GLA, MAPK1, MAPK10
35	cyclic amp32 18	9.2	NGFR, NGF, NTRK1, MAPK10, BDNF
36	nmda32 42	9.2	NGFR, NGF, MAPK1, MAPK10, BDNF
37	adenylate32	8.2	NGF, NTRK1, MAPK1, MAPK10, BDNF
38	forskolin32 42 9 9	11.2	NGFR, NGF, MAPK1, MAPK10, BDNF
39	thymidine32 18	9.1	NGFR, NGF, MAPK1, MAPK10, BDNF
40	arachidonic acid32 9 18 9	11.1	NGFR, NTRK1, ALOXE3, ALOX12B, MAPK10, BDNF
41	cycloheximide32	8.1	NGF, NTRK1, MAPK1, MAPK10, BDNF
42	k252a32	8.0	BDNF, MAPK10, MAPK1, NTRK1, NGF, NGFR
43	wortmannin32 42	9.0	NGFR, NGF, NTRK1, MAPK1, MAPK10, BDNF
44	phosphoinositide32	8.0	NGFR, NGF, NTRK1, MAPK1, MAPK10, BDNF
45	vegf32	7.9	NGFR, NGF, NTRK1, MAPK1, MAPK10, BDNF
46	phosphatidylinositol32	7.9	NGFR, NGF, NTRK1, MAPK1, MAPK10, BDNF
47	threonine32	7.8	NGFR, NGF, NTRK1, GLA, IKBKAP, MAPK1
48	retinoic acid32 42 18	9.8	NGFR, NGF, NTRK1, MAPK1, MAPK10, BDNF
49	tyrosine32	7.1	NGFR, NGF, PKLR, NTRK1, MAPK1, MAPK10
50	serine32	6.8	NGFR, NGF, PKLR, NTRK1, GLA, IKBKAP

Cellular components related to anhidrosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endosome	GO:005768	9.5	NTRK1, NGF, NGFR

Biological processes related to anhidrosis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of axonogenesis	GO:050770	9.8	NGF, NGFR
2	mechanoreceptor differentiation	GO:042490	9.7	BDNF, NTRK1
3	positive regulation of axonogenesis	GO:050772	9.7	NGFR, NGF
4	activation of MAPKK activity	GO:000186	9.6	MAPK1, NTRK1, NGF
5	Ras protein signal transduction	GO:007265	9.5	NGF, NTRK1, MAPK1
6	nerve development	GO:021675	9.4	BDNF, NGFR
7	negative regulation of neuron apoptotic process	GO:043524	9.4	BDNF, NTRK1, NGF
8	nerve growth factor receptor signaling pathway	GO:048011	9.2	NGFR, NGF, NTRK1, MAPK1
9	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	8.8	MAPK10, MAPK1

Molecular functions related to anhidrosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lipoxygenase activity	GO:016165	9.7	ALOX12B, ALOXE3
2	nerve growth factor binding	GO:048406	9.5	NTRK1, NGFR
3	ATP binding	GO:005524	7.5	NTRK1, IKBKAP, CCT5, MAPK1, MAPK10, PKLR