Aliases & Classifications for Anhidrosis

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 29ICD9CM, 36MeSH, 59SNOMED-CT, 42NCIt, 27ICD10
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Aliases & Descriptions for Anhidrosis:

Name: Anhidrosis 10 47 12 65
Absence of Sweating 10
 
Adiaphoresis 10


Classifications:



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Disease Ontology10 DOID:11156
ICD9CM29 705.0
MeSH36 D007007
NCIt42 C34385
ICD1027 L74.4

Summaries for Anhidrosis

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Wikipedia:68 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards based summary: Anhidrosis, also known as absence of sweating, is related to neuropathy, hereditary sensory and autonomic, type v and pyruvate kinase deficiency. An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Tyrosine Kinase, Receptor, Type 1), and among its related pathways are Activation of TRKA receptors and 14-3-3 and Regulation of BAD Activity. Affiliated tissues include skin, testes and t cells, and related mouse phenotypes are integument and normal.

Related Diseases for Anhidrosis

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Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy, hereditary sensory and autonomic, type v30.4NGF, NTRK1
2pyruvate kinase deficiency29.9NTRK1, PKLR
3insensitivity to pain, congenital, with anhidrosis10.7
4neuropathy10.6
5anhidrosis, isolated, with normal sweat glands10.4
6hypohidrosis10.3
7autonomic neuropathy10.3
8alopecia10.3
9miliaria10.3
10horner's syndrome10.2
11ectodermal dysplasia10.2
12cholinergic urticaria10.2
13urticaria10.2
14harlequin syndrome10.2
15parasitic conjunctivitis10.1NGF, NTRK1
16thrombotic thrombocytopenic purpura, familial10.1NGF, NTRK1
17ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive10.1
18ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant10.1
19ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.1
20multiple system atrophy10.1
21leprosy10.1
22ectodermal dysplasia 1, hypohidrotic, x-linked10.1
23sialadenitis10.1
24dermatitis10.1
25hereditary sensory neuropathy10.1
26impotence10.1
27ptosis10.1
28vasculitis10.1
29van den bosch syndrome10.1
30postural hypotension10.1
31ectodermal dysplasia, hypohidrotic, with immune deficiency10.1
32pruritic urticarial papules plaques of pregnancy10.1NGF, NGFR
33syndactyly10.1GLA, NTRK1
34imperforate anus10.1NGFR, NTRK1
35autosomal dominant disease10.0NGF, NTRK1
36leukocyte disease10.0NGF, NGFR
37intermittent squint10.0NGFR, NTRK1
38diamond-blackfan anemia9.9NGF, NGFR, NTRK1
39fucosidosis9.9
40lung cancer9.9
41ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant9.9
42bjornstad syndrome9.9
43ichthyosis, congenital, autosomal recessive 4a9.9
44cockayne syndrome, type a9.9
45ichthyosis, congenital, autosomal recessive 69.9
46ichthyosis, congenital, autosomal recessive 109.9
47shwachman-diamond syndrome9.9
48rothmund-thomson syndrome9.9
49cockayne syndrome, type b9.9
50ichthyosis, congenital, autosomal recessive 89.9

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to anhidrosis

Symptoms for Anhidrosis

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Drugs & Therapeutics for Anhidrosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and AnhidrosisNot yet recruitingNCT02624310Phase 2

Search NIH Clinical Center for Anhidrosis

Genetic Tests for Anhidrosis

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Anatomical Context for Anhidrosis

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MalaCards organs/tissues related to Anhidrosis:

33
Skin, Testes, T cells, Neutrophil, Bone, Lung, Spinal cord

Animal Models for Anhidrosis or affiliated genes

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MGI Mouse Phenotypes related to Anhidrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1IKBKG, NGF, NGFR, NTRK1, ORAI1
2MP:00028737.9IKBKG, ITPR2, NGF, NGFR, NTRK1, PKLR
3MP:00053787.8IKBKG, ITPR2, NGF, NGFR, NTRK1, ORAI1
4MP:00053867.5GLA, IKBKG, ITPR2, NGF, NGFR, NTRK1
5MP:00053877.2GLA, IKBKG, NGFR, NTRK1, ORAI1, PKLR
6MP:00107687.0IKBKG, ITPR2, NGF, NGFR, NTRK1, ORAI1

Publications for Anhidrosis

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Articles related to Anhidrosis:

(show top 50)    (show all 269)
idTitleAuthorsYear
1
Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. (25627679)
2015
2
Anesthetic Management of Patients with Congenital Insensitivity to Pain with Anhidrosis: A Retrospective Analysis of 358 Procedures Performed Under General Anesthesia. (26484462)
2015
3
Congenital insensitivity to pain and anhidrosis syndrome: two cases involving a brother and sister. (25421205)
2014
4
Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis. (25060903)
2014
5
Old fractures in two patients with congenital insensitivity to pain with anhidrosis: radiological findings. (23478071)
2013
6
Acquired generalized anhidrosis: review of the literature and report of a case with lymphocytic hidradenitis and sialadenitis successfully treated with cyclosporine. (24191980)
2013
7
Nerve growth factor and the physiology ofA pain: lessons from congenital insensitivity to pain with anhidrosis. (22882139)
2012
8
Unilateral anhidrosis: a rare presentation of atrial myxoma? (23230264)
2012
9
Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis. (22653642)
2012
10
Right ptosis, anhidrosis, and miosis developed in a 49-year-old man with chronic dry cough for 2 months. (22796847)
2012
11
Anhidrosis after anterior retroperitoneal approach for L4-L5 artificial disc replacement. (21570302)
2011
12
A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis. (21708027)
2011
13
Evaluation of nonnociceptive sensation in patients with congenital insensitivity to pain with anhidrosis. (20013280)
2010
14
Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis. (20977328)
2010
15
Clinical and genetic analysis of Korean patients with congenital insensitivity to pain with anhidrosis. (19618435)
2009
16
Nerve growth factor, interoception, and sympathetic neuron: lesson from congenital insensitivity to pain with anhidrosis. (19201660)
2009
17
Isolated generalised anhidrosis induced by postganglionic sympathetic skin nerve fibre degeneration: an incomplete Ross syndrome? (18356251)
2008
18
Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. (18077166)
2008
19
Idiopathic generalized anhidrosis: a feature of panautonomic failure. (18797081)
2008
20
Clinical and genetic aspects of congenital insensitivity to pain with anhidrosis]. (15999564)
2005
21
A novel lymphocyte signaling defect: trk A mutation in the syndrome of congenital insensitivity to pain and anhidrosis (CIPA). (15163901)
2004
22
Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission. (15505168)
2004
23
Intrasinus wood foreign body causing orbital cellulitis in congenital insensitivity to pain with anhidrosis syndrome. (14752319)
2004
24
Congenital insensitivity of pain with anhidrosis. (12619965)
2003
25
Post-herpetic neuralgia in a patient with congenital insensitivity to pain and anhidrosis. (14566502)
2002
26
Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (12102460)
2002
27
Congenital insensitivity to pain with anhidrosis (CIPA): the spectrum of radiological findings. (11685437)
2001
28
Congenital insensitivity to pain with anhidrosis: an NGF/TrkA-related disorder. (11241480)
2001
29
Two novel mutant alleles of the gene encoding neurotrophic tyrosine kinase receptor type 1 (NTRK1) in a patient with congenital insensitivity to pain with anhidrosis: a splice junction mutation in intron 5 and cluster of four mutations in exon 15. (11139246)
2001
30
Neurophysiologic studies in congenital insensitivity to pain with anhidrosis. (11744315)
2001
31
Congenital insensitivity to pain with anhidrosis. (11483399)
2001
32
Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli- Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. (10861667)
2000
33
The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor. (10567924)
2000
34
Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with congenital insensitivity to pain with anhidrosis. (11071380)
2000
35
Congenital insensitivity to pain with anhidrosis. Report of a case and review of the literature. (10842874)
2000
36
Congenital insensitivity to pain with anhidrosis: ocular and systemic manifestations. (10088743)
1999
37
Traumatic Horner syndrome without anhidrosis. (10380140)
1999
38
Unilateral loss of facial flushing and sweating with contralateral anhidrosis: harlequin syndrome or Adie's syndrome? (8292878)
1993
39
Axonal degeneration of the peripheral nerves and postganglionic anhidrosis in a patient with multiple sclerosis. (1965353)
1990
40
Familial generalized anhidrosis. (2401613)
1990
41
Idiopathic acquired generalized anhidrosis: electron-microscopic and immunohistochemical studies and analysis of lectin-binding pattern of the cell membrane. (2721803)
1989
42
Equine anhidrosis: a survey of affected horses in Florida. (7068500)
1982
43
Studies on the mechanism of topical anhidrosis due to polyvalent cations. (19469924)
1981
44
The role of bacteria in anhidrosis. (4750804)
1973
45
Miliaria and anhidrosis. 3. Multiple small patches and the effects of different periods of occlusion. (5030233)
1972
46
Pruritus and acquired anhidrosis. Two unusual cases. (5822371)
1969
47
Congenital sensory neuropathy with anhidrosis. (4171106)
1968
48
Miliaria and anhidrosis. I. Experimental production in volunteers. (6062874)
1967
49
A form of ectodermal dysplasia; hypotrichosis with anhidrosis and anodontia]. (13023176)
1952
50
Tropical anidrotic asthenia (thermogenic anhidrosis) and its relationship to prickly heat. (20244419)
1946

Variations for Anhidrosis

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Expression for genes affiliated with Anhidrosis

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Search GEO for disease gene expression data for Anhidrosis.

Pathways for genes affiliated with Anhidrosis

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Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7NGF, NTRK1
29.6NGF, NGFR
39.5ITPR2, ORAI1
49.3IKBKG, ORAI1
59.3NGF, NGFR, NTRK1
69.3NGF, NGFR, NTRK1
79.3NGF, NGFR, NTRK1
8
Show member pathways
9.3NGF, NGFR, NTRK1
9
Show member pathways
9.3NGF, NGFR, NTRK1
10
Apoptosis (KEGG)
Show member pathways
9.2NGF, NGFR, NTRK1
11
Show member pathways
9.2IKBKG, NGFR, NTRK1
12
Show member pathways
9.1IKBKG, NGF, NGFR
13
Show member pathways
9.1IKBKG, NGF, NGFR
14
Show member pathways
9.1IKBKG, NGF, NGFR
159.1IKBKG, NGF, NGFR
16
Show member pathways
8.9ITPR2, NGF, NGFR, NTRK1
17
Show member pathways
8.7IKBKG, NGF, NGFR, NTRK1
18
Show member pathways
8.4IKBKG, ITPR2, NGF, NGFR, NTRK1

GO Terms for genes affiliated with Anhidrosis

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Cellular components related to Anhidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:00057689.3NGF, NGFR, NTRK1

Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004328110.2NGF, NGFR
2positive regulation of synaptic transmission, glutamatergicGO:005196810.2NGFR, NTRK1
3positive regulation of axonogenesisGO:005077210.1NGF, NGFR
4nerve growth factor signaling pathwayGO:003818010.0NGF, NTRK1
5regulation of axonogenesisGO:005077010.0NGF, NGFR
6negative regulation of cell cycleGO:00457869.9NGF, NGFR
7negative regulation of neuron deathGO:19012159.8IKBKG, NTRK1
8activation of phospholipase C activityGO:00072029.7ITPR2, NGF, NTRK1
9sensory perception of painGO:00192339.5NGF, NGFR, NTRK1
10negative regulation of neuron apoptotic processGO:00435249.3NGF, NGFR, NTRK1
11neurotrophin TRK receptor signaling pathwayGO:00480118.9ITPR2, NGF, NGFR, NTRK1

Molecular functions related to Anhidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neurotrophin bindingGO:00431219.7NGFR, NTRK1
2nerve growth factor bindingGO:00484069.4NGFR, NTRK1

Sources for Anhidrosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet