Aliases & Classifications for Anhidrosis

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Aliases & Descriptions for Anhidrosis:

Name: Anhidrosis 10 47 12 65
Absence of Sweating 10
 
Adiaphoresis 10

Classifications:



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Disease Ontology10 DOID:11156
ICD1027 L74.4
ICD9CM29 705.0
MeSH36 D007007
NCIt42 C34385
UMLS65 C0003028

Summaries for Anhidrosis

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Wikipedia:68 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards based summary: Anhidrosis, also known as absence of sweating, is related to pyruvate kinase deficiency and insensitivity to pain, congenital, with anhidrosis, and has symptoms including increased sweating, cold sweat and night sweats. An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways are Activation of TRKA receptors and 14-3-3 and Regulation of BAD Activity. Affiliated tissues include skin, heart and lung, and related mouse phenotypes are integument and vision/eye.

Related Diseases for Anhidrosis

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Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1pyruvate kinase deficiency29.9NTRK1, PKLR
2insensitivity to pain, congenital, with anhidrosis12.3
3anhidrosis, isolated, with normal sweat glands12.1
4harlequin syndrome11.4
5van den bosch syndrome10.9
6hypohidrosis10.9
7horner's syndrome10.5
8neuropathy, hereditary sensory and autonomic, type v10.4NGF, NTRK1
9oral cavity carcinoma in situ10.4NGF, NTRK1
10neuropathy10.4
11thrombotic thrombocytopenic purpura, familial10.3NGF, NTRK1
12patent ductus arteriosus10.2GLA, NTRK1
13jmp syndrome10.2NGF, NTRK1
14pruritic urticarial papules plaques of pregnancy10.1NGF, NGFR
15brachial plexus neuropathy10.1NGFR, NTRK1
16autonomic neuropathy10.1
17kidney cancer10.1NGF, NTRK1
18alopecia10.0
19miliaria10.0
20trichomoniasis10.0NGFR, NTRK1
21ectodermal dysplasia10.0
22tibial nerve palsy9.9NGF, NGFR
23cholinergic urticaria9.9
24urticaria9.9
25dermatitis9.9
26ovarian large-cell neuroendocrine carcinoma9.9NGFR, NTRK1
27suppurative otitis media9.9NGF, NTRK1
28leprosy9.8
29hereditary sensory neuropathy9.8
30ptosis9.8
31sialadenitis9.8
32impotence9.8
33vasculitis9.8
34headache9.8
35postural hypotension9.8
36ischemic neuropathy9.8NGF, NGFR, NTRK1
37pheochromocytoma9.8NGF, NGFR, NTRK1
38ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive9.8
39ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant9.8
40ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant9.8
41ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive9.8
42ichthyosis, congenital, autosomal recessive 4a9.8
43ichthyosis, congenital, autosomal recessive 69.8
44ichthyosis, congenital, autosomal recessive 109.8
45ichthyosis, congenital, autosomal recessive 89.8
46ichthyosis, congenital, autosomal recessive 119.8
47ichthyosis, congenital, autosomal recessive 79.8
48immunodeficiency 99.8
49ichthyosis, congenital, autosomal recessive 19.8
50ichthyosis, congenital, autosomal recessive 99.8

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to anhidrosis

Symptoms for Anhidrosis

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UMLS symptoms related to Anhidrosis:


increased sweating, cold sweat, night sweats

Drugs & Therapeutics for Anhidrosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and AnhidrosisWithdrawnNCT02624310Phase 2

Search NIH Clinical Center for Anhidrosis

Genetic Tests for Anhidrosis

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Anatomical Context for Anhidrosis

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MalaCards organs/tissues related to Anhidrosis:

33
Skin, Heart, Lung, Brain, Kidney, Prostate, Breast

Animal Models for Anhidrosis or affiliated genes

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MGI Mouse Phenotypes related to Anhidrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.4IKBKG, ITPR2, NGF, NGFR, NTRK1, ORAI1
2MP:00053918.3GLA, NGF, NGFR, NTRK1, ORAI1
3MP:00028738.3IKBKG, ITPR2, NGF, NGFR, NTRK1, PKLR
4MP:00053877.3GLA, IKBKG, NGFR, NTRK1, ORAI1, PKLR
5MP:00053766.9GLA, IKBKG, ITPR2, NGF, NGFR, ORAI1
6MP:00053786.9GLA, IKBKG, ITPR2, NGF, NGFR, NTRK1
7MP:00107686.5GLA, IKBKG, ITPR2, NGF, NGFR, NTRK1

Publications for Anhidrosis

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Articles related to Anhidrosis:

(show top 50)    (show all 279)
idTitleAuthorsYear
1
Raeder's Paratrigeminal Syndrome: Headache and Horner's Lacking Anhidrosis. (26902244)
2016
2
Idiopathic segmental anhidrosis associated with varicella. (27206820)
2016
3
Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. (25627679)
2015
4
Anesthetic Management of Patients with Congenital Insensitivity to Pain with Anhidrosis: A Retrospective Analysis of 358 Procedures Performed Under General Anesthesia. (26484462)
2015
5
Congenital insensitivity to pain and anhidrosis syndrome: two cases involving a brother and sister. (25421205)
2014
6
Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis. (25060903)
2014
7
Old fractures in two patients with congenital insensitivity to pain with anhidrosis: radiological findings. (23478071)
2013
8
Acquired generalized anhidrosis: review of the literature and report of a case with lymphocytic hidradenitis and sialadenitis successfully treated with cyclosporine. (24191980)
2013
9
Nerve growth factor and the physiology ofA pain: lessons from congenital insensitivity to pain with anhidrosis. (22882139)
2012
10
Unilateral anhidrosis: a rare presentation of atrial myxoma? (23230264)
2012
11
Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis. (22653642)
2012
12
Right ptosis, anhidrosis, and miosis developed in a 49-year-old man with chronic dry cough for 2 months. (22796847)
2012
13
Anhidrosis after anterior retroperitoneal approach for L4-L5 artificial disc replacement. (21570302)
2011
14
A short in-frame deletion in NTRK1 tyrosine kinase domain caused by a novel splice site mutation in a patient with congenital insensitivity to pain with anhidrosis. (21708027)
2011
15
Evaluation of nonnociceptive sensation in patients with congenital insensitivity to pain with anhidrosis. (20013280)
2010
16
Clinical and genetic analysis of Korean patients with congenital insensitivity to pain with anhidrosis. (19618435)
2009
17
Nerve growth factor, interoception, and sympathetic neuron: lesson from congenital insensitivity to pain with anhidrosis. (19201660)
2009
18
Isolated generalised anhidrosis induced by postganglionic sympathetic skin nerve fibre degeneration: an incomplete Ross syndrome? (18356251)
2008
19
Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. (18077166)
2008
20
Idiopathic generalized anhidrosis: a feature of panautonomic failure. (18797081)
2008
21
Clinical and genetic aspects of congenital insensitivity to pain with anhidrosis]. (15999564)
2005
22
A novel lymphocyte signaling defect: trk A mutation in the syndrome of congenital insensitivity to pain and anhidrosis (CIPA). (15163901)
2004
23
Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission. (15505168)
2004
24
Intrasinus wood foreign body causing orbital cellulitis in congenital insensitivity to pain with anhidrosis syndrome. (14752319)
2004
25
Congenital insensitivity of pain with anhidrosis. (12619965)
2003
26
Post-herpetic neuralgia in a patient with congenital insensitivity to pain and anhidrosis. (14566502)
2002
27
Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (12102460)
2002
28
Congenital insensitivity to pain with anhidrosis (CIPA): the spectrum of radiological findings. (11685437)
2001
29
Congenital insensitivity to pain with anhidrosis: an NGF/TrkA-related disorder. (11241480)
2001
30
Two novel mutant alleles of the gene encoding neurotrophic tyrosine kinase receptor type 1 (NTRK1) in a patient with congenital insensitivity to pain with anhidrosis: a splice junction mutation in intron 5 and cluster of four mutations in exon 15. (11139246)
2001
31
Neurophysiologic studies in congenital insensitivity to pain with anhidrosis. (11744315)
2001
32
Congenital insensitivity to pain with anhidrosis. (11483399)
2001
33
Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli- Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. (10861667)
2000
34
The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor. (10567924)
2000
35
Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with congenital insensitivity to pain with anhidrosis. (11071380)
2000
36
Congenital insensitivity to pain with anhidrosis. Report of a case and review of the literature. (10842874)
2000
37
Congenital insensitivity to pain with anhidrosis: ocular and systemic manifestations. (10088743)
1999
38
Traumatic Horner syndrome without anhidrosis. (10380140)
1999
39
Unilateral loss of facial flushing and sweating with contralateral anhidrosis: harlequin syndrome or Adie's syndrome? (8292878)
1993
40
Axonal degeneration of the peripheral nerves and postganglionic anhidrosis in a patient with multiple sclerosis. (1965353)
1990
41
Familial generalized anhidrosis. (2401613)
1990
42
Idiopathic acquired generalized anhidrosis: electron-microscopic and immunohistochemical studies and analysis of lectin-binding pattern of the cell membrane. (2721803)
1989
43
Equine anhidrosis: a survey of affected horses in Florida. (7068500)
1982
44
Studies on the mechanism of topical anhidrosis due to polyvalent cations. (19469924)
1981
45
The role of bacteria in anhidrosis. (4750804)
1973
46
Miliaria and anhidrosis. 3. Multiple small patches and the effects of different periods of occlusion. (5030233)
1972
47
Pruritus and acquired anhidrosis. Two unusual cases. (5822371)
1969
48
Congenital sensory neuropathy with anhidrosis. (4171106)
1968
49
Miliaria and anhidrosis. I. Experimental production in volunteers. (6062874)
1967
50
A form of ectodermal dysplasia; hypotrichosis with anhidrosis and anodontia]. (13023176)
1952

Variations for Anhidrosis

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Expression for genes affiliated with Anhidrosis

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Search GEO for disease gene expression data for Anhidrosis.

Pathways for genes affiliated with Anhidrosis

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Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8NGF, NTRK1
29.7NGF, NGFR
39.6ITPR2, ORAI1
49.5IKBKG, ORAI1
59.4NGF, NGFR, NTRK1
69.4NGF, NGFR, NTRK1
7
Show member pathways
9.4NGF, NGFR, NTRK1
8
Show member pathways
9.3IKBKG, NGFR, NTRK1
99.2IKBKG, NGF, NGFR
10
Show member pathways
9.2IKBKG, NGF, NGFR
11
Show member pathways
9.2IKBKG, NGF, NGFR
12
Show member pathways
9.2IKBKG, NGF, NGFR
13
Show member pathways
9.0ITPR2, NGF, NGFR, NTRK1
14
Show member pathways
9.0IKBKG, ITPR2, NGF, NTRK1
15
Show member pathways
8.9IKBKG, NGF, NGFR, NTRK1
16
Show member pathways
8.6IKBKG, ITPR2, NGF, NGFR, NTRK1

GO Terms for genes affiliated with Anhidrosis

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Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004328110.1NGF, NGFR
2transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.9NGF, NTRK1
3negative regulation of cell cycleGO:00457869.8NGF, NGFR
4negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.7NGF, NGFR
5sensory perception of painGO:00192339.6NGFR, NTRK1
6activation of phospholipase C activityGO:00072029.4ITPR2, NGF, NTRK1
7activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.4NGF, NGFR

Sources for Anhidrosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet