Aliases & Classifications for Anhidrosis

MalaCards integrated aliases for Anhidrosis:

Name: Anhidrosis 12 51 14 69
Absence of Sweating 12
Adiaphoresis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11156
ICD10 32 L74.4
ICD9CM 34 705.0
MeSH 41 D007007
NCIt 46 C34385
UMLS 69 C0003028

Summaries for Anhidrosis

MalaCards based summary : Anhidrosis, also known as absence of sweating, is related to hereditary sensory neuropathy and autonomic neuropathy, and has symptoms including increased sweating An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways/superpathways are TGF-Beta Pathway and Phospholipase-C Pathway. The drugs Acetylcholine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil, and related phenotypes are growth/size/body region and behavior/neurological

Wikipedia : 72 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

Related Diseases for Anhidrosis

Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 hereditary sensory neuropathy 31.3 NGF NTRK1
2 autonomic neuropathy 29.9 NGF NTRK1
3 insensitivity to pain, congenital, with anhidrosis 12.5
4 anhidrosis, isolated, with normal sweat glands 12.3
5 anhidrosis, familial generalized, with abnormal or absent sweat glands 11.9
6 harlequin syndrome 11.5
7 van den bosch syndrome 11.4
8 hypohidrosis 11.4
9 horner's syndrome 11.2
10 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 11.1
11 ectodermal dysplasia 1, hypohidrotic, x-linked 11.1
12 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.8
13 horner syndrome, congenital 10.8
14 ichthyosis, congenital, autosomal recessive 2 10.8
15 ichthyosis, congenital, autosomal recessive 1 10.8
16 ichthyosis, congenital, autosomal recessive 4a 10.8
17 ichthyosis, congenital, autosomal recessive 11 10.8
18 ichthyosis, congenital, autosomal recessive 5 10.8
19 ichthyosis, congenital, autosomal recessive 3 10.8
20 ichthyosis, congenital, autosomal recessive 6 10.8
21 immunodeficiency 9 10.8
22 ichthyosis, congenital, autosomal recessive 8 10.8
23 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.8
24 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.8
25 splenomegaly, cytopenia, and vision loss 10.8
26 ichthyosis, congenital, autosomal recessive 7 10.8
27 ichthyosis, congenital, autosomal recessive 9 10.8
28 ichthyosis, congenital, autosomal recessive 10 10.8
29 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 10.8
30 helix syndrome 10.8
31 episodic pain syndrome, familial, 1 10.7
32 neuropathy 10.4
33 neuropathy, hereditary sensory and autonomic, type v 10.3 NGF NTRK1
34 askin's tumor 10.3 NGF NTRK1
35 prolactin producing pituitary tumor 10.3 NGF NTRK1
36 conjunctival nevus 10.3 NGF NTRK1
37 ocular cicatricial pemphigoid 10.2 NGF NTRK1
38 cerebral cavernous malformations 2 10.2 NGF NTRK1
39 prurigo nodularis 10.1 NGF NGFR
40 olfactory neuroblastoma 10.1 NGFR NTRK1
41 ocular dominance 10.1 NGF NGFR
42 peripheral nervous system neoplasm 10.1 NGF NTRK1
43 alopecia 10.0
44 ectodermal dysplasia 10.0
45 miliaria 10.0
46 autonomic nervous system neoplasm 10.0 NGF NTRK1
47 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
48 bladder disease 9.9 CHRM3 NGF
49 sweat gland disease 9.9 GLA NGF NTRK1
50 diabetic neuropathy 9.9 NGF NGFR NTRK1

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to Anhidrosis

Symptoms & Phenotypes for Anhidrosis

UMLS symptoms related to Anhidrosis:


increased sweating

MGI Mouse Phenotypes related to Anhidrosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.01 NGF CHRM3 GLA NGFR IKBKG NTRK1
2 behavior/neurological MP:0005386 10 CHRM3 NGF GLA NGFR IKBKG NTRK1
3 homeostasis/metabolism MP:0005376 9.97 PKLR ORAI1 NGF CHRM3 GLA NGFR
4 cardiovascular system MP:0005385 9.91 ITPR2 CHRM3 NGF GLA NGFR IKBKG
5 mortality/aging MP:0010768 9.86 PKLR ORAI1 NGF GLA NGFR IKBKG
6 integument MP:0010771 9.8 ORAI1 NGF NGFR IKBKG NTRK1 ITPR2
7 muscle MP:0005369 9.55 CHRM3 NGF GLA NGFR NTRK1
8 normal MP:0002873 9.43 PKLR NGF NGFR IKBKG NTRK1 ITPR2
9 vision/eye MP:0005391 9.1 NGF CHRM3 GLA NGFR NTRK1 ORAI1

Drugs & Therapeutics for Anhidrosis

Drugs for Anhidrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved 51-84-3 187
2
Ethanol Approved 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2 Droxidopa (L-DOPS);Placebo
2 Role of Indicator Test (Neuropad) in Detecting Diabetic Neuropathy Completed NCT00895440
3 Assessment of Small Fiber Neuropathy in Rare Diseases Using Sudoscan Recruiting NCT02985710

Search NIH Clinical Center for Anhidrosis

Genetic Tests for Anhidrosis

Anatomical Context for Anhidrosis

MalaCards organs/tissues related to Anhidrosis:

38
Skin, Testes, Neutrophil, T Cells, Lung, Spinal Cord, Kidney

Publications for Anhidrosis

Articles related to Anhidrosis:

(show top 50) (show all 314)
# Title Authors Year
1
NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis. ( 29407522 )
2018
2
Successful treatment of chronic intractable pain with risperidone in a patient with acquired idiopathic generalized anhidrosis. ( 29446147 )
2018
3
Recurrent and novel mutations in the NTRK1 gene lead to rare congenital insensitivity to pain with anhidrosis in two Chinese patients. ( 28192073 )
2017
4
Novel NTRK1 mutations associated with congenital insensitivity to pain with anhidrosis verified by functional studies. ( 28177573 )
2017
5
Observation of water evaporation and stratum corneum hydration and pH during the clinical course of a patient with acquired idiopathic generalized anhidrosis. ( 28677824 )
2017
6
Idiopathic segmental anhidrosis. ( 28541441 )
2017
7
Degranulation and shrinkage of dark cells in eccrine glands and elevated serum carcinoembryonic antigen in patients with acquired idiopathic generalized anhidrosis. ( 28662305 )
2017
8
Unilateral facial and upper truncal anhidrosis and absence of physiological flushing: A case of idiopathic harlequin syndrome. ( 28799533 )
2017
9
Total Hip Arthroplasty in an Inveterate Femoral Neck Fracture in a Patient with Congenital Insensitivity to Pain with Anhidrosis. ( 29270564 )
2017
10
Prognosis of acquired idiopathic generalized anhidrosis. ( 28771990 )
2017
11
Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores. ( 28328088 )
2017
12
Skin Ultrastructural Findings in Acquired Generalized Hypohidrosis/Anhidrosis in a Patient with Subclinical SjAPgren Syndrome. ( 28448095 )
2017
13
Identification of a novel nonsense mutation of the neurotrophic tyrosine kinase receptor type 1 gene in two siblings with congenital insensitivity to pain with anhidrosis. ( 28345382 )
2017
14
Could Congenital Insensitivity to Pain with Anhidrosis Be Misdiagnosed as Papillon-LefA"vre Syndrome? ( 29142767 )
2017
15
Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case. ( 29142185 )
2017
16
An Innovative Cooling Jacket to Combat Heat Intolerance in Children with Anhidrosis. ( 28429544 )
2017
17
Acquired anhidrosis associated with systemic sarcoidosis: Quantification of nerve fibers around eccrine glands by confocal microscopy. ( 28796884 )
2017
18
Case of autoimmune autonomic ganglionopathy manifesting anhidrosis. ( 28620980 )
2017
19
The relevance of anhidrosis in Horner syndrome: Analysis of an image. ( 29277520 )
2017
20
Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. ( 28686597 )
2017
21
Anesthetic management during adenotonsillectomy for twins with congenital insensitivity to pain with anhidrosis: two case reports. ( 28838318 )
2017
22
Congenital Insensitivity to Pain and Anhidrosis. ( 26848454 )
2016
23
Congenital insensitivity to pain with anhidrosis in Sudanese children. ( 28096563 )
2016
24
Unilateral anhidrosis: A rare complication of thoracic epidural analgesia. ( 26612960 )
2016
25
Raeder's Paratrigeminal Syndrome: Headache and Horner's Lacking Anhidrosis. ( 26902244 )
2016
26
Orthopaedic manifestations of congenital indifference to pain with anhidrosis (Hereditary Sensory and Autonomic Neuropathy type IV). ( 27637569 )
2016
27
Mutations in TrkA causing congenital insensitivity to pain with anhidrosis (CIPA) induce misfolding, aggregation and mutation-dependent neurodegeneration by dysfunction of the autophagic flux. ( 27551041 )
2016
28
Congenital insensitivity to pain with anhidrosis: A report of two siblings with a novel mutation in (TrkA) NTRK1 gene in a Saudi family. ( 27772781 )
2016
29
Acquired anhidrosis in a case of autoimmune autonomic ganglionopathy. ( 27774700 )
2016
30
Phenotypes and Genotypes in Five Children with Congenital Insensitivity to Pain with Anhidrosis. ( 27265460 )
2016
31
Genetic Disorders with Dyshidrosis: Ectodermal Dysplasia, Incontinentia Pigmenti, Fabry Disease, and Congenital Insensitivity to Pain with Anhidrosis. ( 27584961 )
2016
32
Clinical Analysis and Management of Acquired Idiopathic Generalized Anhidrosis. ( 27584965 )
2016
33
Congenital insensitivity to pain and anhidrosis: Case report and review of findings along neuro-immune axis in the disorder. ( 27772759 )
2016
34
Harlequin syndrome with contralateral anhidrosis after an upper chest gunshot wound. ( 27535737 )
2016
35
Purple hands in multiple system atrophy: Global anhidrosis with preserved acral sweating. ( 27298449 )
2016
36
Generalised Anhidrosis Secondary to Intracranial Haemorrhage. ( 27125348 )
2016
37
Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction. ( 27859565 )
2016
38
Anesthetic considerations in a parturient with congenital insensitivity to pain with anhidrosis. ( 27884666 )
2016
39
Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan. ( 27774633 )
2016
40
Idiopathic segmental anhidrosis associated with varicella. ( 27206820 )
2016
41
A Girl with No Pain: Congenital Insensitivity To Pain and Anhidrosis (HSAN) Type IV - A Case Report. ( 27042602 )
2016
42
Combined cholinergic urticaria and cold-induced cholinergic urticaria with acquired idiopathic generalized anhidrosis. ( 25838106 )
2015
43
A lady presenting with segmental anhidrosis and heat intolerance. ( 25821738 )
2015
44
Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum CEA level and disease activity. ( 26446433 )
2015
45
Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. ( 25627679 )
2015
46
Acquired Idiopathic Generalized Anhidrosis. ( 26288446 )
2015
47
Congenital Insensitivity to Pain without Anhidrosis: Orodental Problems and Management. ( 26457210 )
2015
48
Congenital insensitivity to pain with anhidrosis. ( 26032179 )
2015
49
Novel and novel de novo mutations in NTRK1 associated with congenital insensitivity to pain with anhidrosis: a case report. ( 25984678 )
2015
50
Therapeutic effects and prevention of recurrence of acquired idiopathic generalized anhidrosis via i.v. immunoglobulin treatment. ( 26508392 )
2015

Variations for Anhidrosis

Expression for Anhidrosis

Search GEO for disease gene expression data for Anhidrosis.

Pathways for Anhidrosis

Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 IKBKG ITPR2 NGF NGFR NTRK1
2
Show member pathways
12.78 ITPR2 NGF NGFR NTRK1
3
Show member pathways
12.68 IKBKG NGF NGFR NTRK1
4
Show member pathways
12.68 IKBKG ITPR2 NGF NGFR NTRK1
5 12.49 IKBKG NGF NGFR NTRK1
6
Show member pathways
12.44 IKBKG NGF NGFR NTRK1
7
Show member pathways
12.36 IKBKG ITPR2 NGF NTRK1
8
Show member pathways
12.34 IKBKG ITPR2 NGF NGFR
9 12.31 NGF NGFR NTRK1
10
Show member pathways
12.26 IKBKG ITPR2 NGF NGFR NTRK1
11
Show member pathways
12.18 IKBKG NGFR NTRK1
12
Show member pathways
12.11 CHRM3 ITPR2 PKLR
13
Show member pathways
11.98 CHRM3 ITPR2 ORAI1
14 11.7 NGF NGFR NTRK1
15
Show member pathways
11.44 IKBKG NGF NGFR NTRK1
16
Show member pathways
11.41 IKBKG NGF NGFR
17
Show member pathways
11.32 IKBKG NGF NGFR
18
Show member pathways
11.22 NGF NGFR NTRK1
19 11.14 IKBKG ORAI1
20 11.08 IKBKG NGF NGFR NTRK1
21 11.05 NGF NGFR
22
Show member pathways
10.47 NGF NTRK1

GO Terms for Anhidrosis

Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron death GO:1901215 9.43 IKBKG NTRK1
2 activation of MAPKK activity GO:0000186 9.4 NGF NTRK1
3 phosphatidylinositol-mediated signaling GO:0048015 9.37 NGF NTRK1
4 positive regulation of axonogenesis GO:0050772 9.32 NGF NGFR
5 cellular response to amyloid-beta GO:1904646 9.26 NGFR NTRK1
6 positive regulation of Ras protein signal transduction GO:0046579 9.16 NGF NTRK1
7 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 8.96 NGF NGFR
8 neurotrophin TRK receptor signaling pathway GO:0048011 8.8 NGF NGFR NTRK1

Molecular functions related to Anhidrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nerve growth factor binding GO:0048406 8.96 NGFR NTRK1
2 neurotrophin binding GO:0043121 8.62 NGFR NTRK1

Sources for Anhidrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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