MCID: ANH002
MIFTS: 52

Anhidrosis malady

Skin diseases category

Summaries for Anhidrosis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards: Anhidrosis, also known as absence of sweating, is related to neuropathy and autonomic neuropathy. An important gene associated with Anhidrosis is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are Thyroid cancer and p75NTR signals via NF-kB. The compounds forskolin and serine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related mouse phenotypes are integument and no phenotypic analysis.

Description from OMIM:46 206600

Aliases & Classifications for Anhidrosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

anhidrosis 8 10 44 60
absence of sweating 8
adiaphoresis 8


External Ids:

Disease Ontology8 DOID:11156
MeSH34 D007007
NCIt39 C34385
OMIM46 206600
ICD9CM27 705.0
ICD1025 L74.4

Related Diseases for Anhidrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anhidrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy30.8NGF, IKBKAP
2autonomic neuropathy30.3IKBKAP, NGF, NTRK1
3hereditary sensory neuropathy30.3NTRK1, NGF, IKBKAP
4hypohidrosis30.3GLA
5diabetic neuropathy29.8NGF, NGFR, NTRK1
6atopic dermatitis29.7NGF, NGFR, BDNF
7skin disease29.7ALOX12B, NGFR, BDNF
8multiple sclerosis29.7BDNF, MAPK10, NGFR, NGF
9hereditary sensory and autonomic neuropathy iv10.6
10alopecia10.2
11miliaria10.2
12pain disorder10.2
13horner's syndrome10.2
14dermatitis10.1
15sialadenitis10.0
16cholinergic urticaria10.0
17impotence10.0
18leprosy10.0
19urticaria10.0
20vasculitis10.0
21chagas disease10.0NTRK1
22peripheral neuropathy10.0NTRK1
23phaeochromocytoma10.0NGF
24myocardial infarction10.0GLA
25pyruvate kinase deficiency10.0PKLR
26ependymoma10.0NGFR
27neuroaxonal dystrophy10.0NTRK1, NGF
28acute leukemia10.0MAPK10
29down syndrome10.0MAPK10
30allergic rhinitis10.0NGFR, NGF
31prolactinoma10.0NGF, NGFR
32diabetes mellitus10.0PKLR, NGF
33pancreatitis10.0MAPK10
34autosomal recessive congenital ichthyosis10.0ALOXE3, ALOX12B
35hyperglycemia10.0BDNF
36ganglioneuroma10.0NGF, NGFR, NTRK1
37attention deficit hyperactivity disorder10.0BDNF
38cannabis abuse10.0NGF, BDNF
39gaucher's disease10.0GLA, PKLR
40myopathy10.0IKBKAP, NGF, PKLR
41papillary thyroid carcinoma10.0NTRK1, MAPK10
42congenital ichthyosiform erythroderma10.0ALOXE3, ALOX12B
43toxic encephalopathy10.0NGF, BDNF
44asthma10.0NGFR, NGF, IKBKAP
45sensory peripheral neuropathy10.0NGF, NTRK1, BDNF
46hepatocellular carcinoma10.0BDNF, MAPK1
47rett syndrome10.0NGF, NTRK1, BDNF
48neuroepithelioma10.0MAPK10, MAPK1, NGF
49prion disease10.0BDNF, NTRK1, NGF
50allergic asthma10.0NGF, NTRK1, BDNF

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to anhidrosis

Clinical Features for Anhidrosis

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46OMIM
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Clinical features from OMIM:

206600

Drugs & Therapeutics for Anhidrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Anhidrosis

Drug clinical trials:

Search ClinicalTrials for Anhidrosis

Search NIH Clinical Center for Anhidrosis

Search CenterWatch for Anhidrosis

Genetic Tests for Anhidrosis

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Anatomical Context for Anhidrosis

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32MalaCards
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MalaCards organs/tissues related to Anhidrosis:

32
Skin, Testes, Bone, Spinal cord, Lung, T cells

Animal Models for Anhidrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Anhidrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6ALOXE3, ALOX12B, IKBKAP, BDNF
2MP:00030128.3BDNF, NTRK1, NGF, ALOX12B, ALOXE3
3MP:00053698.2NTRK1, MAPK1, NGFR, NGF, GLA, IKBKAP
4MP:00053857.5MAPK10, MAPK1, NGFR, NGF, GLA, IKBKAP
5MP:00053787.3NTRK1, MAPK1, NGFR, NGF, IKBKAP, ALOXE3
6MP:00036317.0BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
7MP:00053866.9BDNF, NTRK1, MAPK10, MAPK1, NGFR, NGF
8MP:00107686.7BDNF, PKLR, NTRK1, MAPK1, NGFR, NGF
9MP:00053766.4BDNF, PKLR, MAPK10, MAPK1, NGFR, NGF

Publications for Anhidrosis

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50PubMed
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Articles related to Anhidrosis:

(show top 50)    (show all 246)
idTitleAuthorsYear
1
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. (23748235)
2014
2
Acquired generalized anhidrosis: review of the literature and report of a case with lymphocytic hidradenitis and sialadenitis successfully treated with cyclosporine. (24191980)
2013
3
360A^ fusion for Charcot spine caused by congenital insensitivity to pain with anhidrosis. (24157171)
2013
4
Variation of muscular structure in congenital insensitivity to pain and anhidrosis. (23498566)
2013
5
Generalized anhidrosis in a child following presumptive H1N1 influenza. (21892655)
2012
6
Virilizing para-adrenocortical adenoma associated with idiopathic-acquired generalized anhidrosis in an adolescent girl. (21648301)
2011
7
Nerve growth factor, pain, itch and inflammation: lessons from congenital insensitivity to pain with anhidrosis. (20977328)
2010
8
Poikilodermia, anhidrosis, hairless body, neurogenic muscle atrophy, and recurrent hematuria: a new syndrome? (20179583)
2010
9
Assessment of cognitive and adaptive behaviour among individuals with congenital insensitivity to pain and anhidrosis. (20089052)
2010
10
Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor. (18955016)
2009
11
Ross syndrome with generalized anhidrosis and localized disabling compensatory hyperhidrosis. (18299650)
2008
12
Successful treatment of acquired idiopathic generalized anhidrosis. (17296922)
2007
13
Use of BIS monitor in a child with congenital insensitivity to pain with anhidrosis. (16618305)
2006
14
Ocular manifestations of congenital insensitivity to pain with anhidrosis. (16490492)
2006
15
Clinical and genetic aspects of congenital insensitivity to pain with anhidrosis]. (15999564)
2005
16
Generalised anhidrosis: different lesion sites demonstrated by microneurography and skin biopsy. (15774454)
2005
17
Desflurane used in a patient with congenital insensitivity to pain with anhidrosis during septic shock. (15366409)
2004
18
Segmental anhidrosis with hyporeflexia associated with congenital spinal deformity: a Ross's syndrome variant or inverse Horner's syndrome? (17642554)
2004
19
Congenital insensitivity of pain with anhidrosis. (12619965)
2003
20
Symptomatic cluster headache in internal carotid artery dissection--consider anhidrosis. (12940812)
2003
21
Acquired idiopathic generalized anhidrosis: a rare cause of heat intolerance. (12780708)
2003
22
Orofacial manifestations of congenital insensitivity to pain with anhidrosis: a report of 24 cases. (12613315)
2002
23
Congenital insensitivity to pain with anhidrosis: an NGF/TrkA-related disorder. (11241480)
2001
24
Two novel mutant alleles of the gene encoding neurotrophic tyrosine kinase receptor type 1 (NTRK1) in a patient with congenital insensitivity to pain with anhidrosis: a splice junction mutation in intron 5 and cluster of four mutations in exon 15. (11139246)
2001
25
Localized syringolymphoid hyperplasia with alopecia and anhidrosis. (11423848)
2001
26
The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor. (10567924)
2000
27
Multisystem involvement in congenital insensitivity to pain with anhidrosis (CIPA), a nerve growth factor receptor(Trk A)-related disorder. (10774995)
2000
28
Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families. (10982191)
2000
29
Unsuccessful surgical treatment of hip dislocation in congenital sensory neuropathy with anhidrosis. A case report. (10068014)
1999
30
Acquired idiopathic generalized anhidrosis with isolated sudomotor neuropathy. (9749605)
1998
31
Congenital insensitivity to pain with anhidrosis. (9347232)
1997
32
Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. (8696348)
1996
33
Serial magnetic resonance images in a patient with congenital sensory neuropathy with anhidrosis and complications resembling heat stroke. (8902724)
1996
34
Acquired generalized hypohidrosis/anhidrosis with subclinical SjAPgren's syndrome: report of a case with diffuse syringolymphoid hyperplasia and lymphocytic sialadenitis. (8698925)
1996
35
Acquired idiopathic generalized anhidrosis: clinical manifestations and histochemical studies. (8523036)
1995
36
Unilateral loss of facial flushing and sweating with contralateral anhidrosis: harlequin syndrome or Adie's syndrome? (8292878)
1993
37
Osteoarthropathy in congenital sensory neuropathy with anhidrosis. (2394050)
1990
38
Congenital insensitivity to pain with anhidrosis. A case report. (1689315)
1990
39
Generalized anhidrosis associated with Fabry's disease. (3119682)
1987
40
Anhidrosis and absence of sweat glands in mice hemizygous for the Tabby gene: supportive evidence for the hypothesis of homology between Tabby and human anhidrotic (hypohidrotic) ectodermal dysplasia (Christ-Siemens-Touraine syndrome). (3782855)
1986
41
Orthopaedic complications in congenital sensory neuropathy with anhidrosis (congenital absence of pain). Report of two cases. (3857834)
1985
42
Autoimmune anhidrosis. (6693589)
1984
43
Anhidrosis in a thoroughbred. (6913312)
1981
44
The role of bacteria in anhidrosis. (4750804)
1973
45
Miliaria and anhidrosis. II. The relationships between miliaria and anhidrosis in man. (6058498)
1967
46
Congenital familial sensory neuropathy with anhidrosis. (4158991)
1966
47
The significance of temporary and alternating ptosis, miosis and anhidrosis. (13272050)
1955
48
A form of ectodermal dysplasia; hypotrichosis with anhidrosis and anodontia]. (13023176)
1952
49
A study of miliaria rubra, tropical anhidrosis and anhidrotic asthenia. (20242508)
1947
50
Tropical anidrotic asthenia (thermogenic anhidrosis) and its relationship to prickly heat. (20244419)
1946

Genetic Variations for Anhidrosis

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Expression for genes affiliated with Anhidrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anhidrosis

Search GEO for disease gene expression data for Anhidrosis.

Pathways for genes affiliated with Anhidrosis

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 51QIAGEN, 49PharmGKB, 59Tocris Bioscience, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems
See all sources

Pathways related to Anhidrosis according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2NTRK1
2
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10.2NGF
3
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9.9NTRK1, NGF
4
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9.9NTRK1, NGF
59.8NGFR, NGF
6
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9.8NGFR, NGF
7
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9.8NGF, NGFR
89.8NGFR, NGF
9
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9.8ALOX12B, ALOXE3
10
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9.7BDNF
11
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9.4NGF, MAPK1, NTRK1
12
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9.4NTRK1, MAPK1, NGF
13
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9.4NGF, MAPK1, NTRK1
14
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9.4NTRK1, MAPK1, NGF
159.3MAPK1, MAPK10
16
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9.3MAPK1, MAPK10
17
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9.3MAPK1, MAPK10
18
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9.2NGFR, MAPK10, NTRK1
19
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9.2NGFR, MAPK10, NTRK1
209.1MAPK1, BDNF
21
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9.0MAPK1, MAPK10, PKLR
229.0NGFR, NTRK1, BDNF
23
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9.0NGF, NGFR, MAPK1, NTRK1
24
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8.9BDNF, NGFR, NGF
25
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8.9MAPK10, MAPK1, NGFR
268.9BDNF, NTRK1, MAPK1
27
Hide members
8.8NGF, MAPK1, MAPK10, NTRK1
288.7BDNF, MAPK1, NGFR
298.7NGF, NGFR, NTRK1, BDNF
30
Hide members
8.7NTRK1, MAPK10, MAPK1, NGFR
31
Hide members
8.5BDNF, MAPK10, MAPK1
32
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8.5BDNF, NTRK1, MAPK1, NGFR
33
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8.5NGFR, MAPK1, NTRK1, BDNF
34
Hide members
8.5BDNF, NTRK1, MAPK1, NGFR
358.3BDNF, MAPK10, NGFR, NGF
36
Hide members
8.2BDNF, NTRK1, MAPK10, MAPK1
37
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8.2BDNF, PKLR, MAPK10, MAPK1
388.2BDNF, NTRK1, MAPK1, NGFR, NGF
39
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8.1BDNF, MAPK10, MAPK1, NGFR
40
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7.9NGF, MAPK1, MAPK10, NTRK1, BDNF
41
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7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
42
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7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
43
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7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
44
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7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
45
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
46
Hide members
7.5NGF, NGFR, MAPK1, MAPK10, NTRK1, BDNF
477.5NGF, NGFR, MAPK1, MAPK10, NTRK1, BDNF

Compounds for genes affiliated with Anhidrosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Anhidrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1forskolin44 49 1112.4NGFR
2serine4410.3PKLR, GLA
3cipa4410.2NTRK1, NGF
412(r)-hpete44 2411.1ALOX12B, ALOXE3
5ag 879449.7NTRK1, NGF, MAPK10
6estradiol valerate449.7NGFR, NGF
7gnrh449.6BDNF, NTRK1
8ganglioside449.6GLA, NGF, NGFR, NTRK1
91,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene449.5MAPK1, MAPK10
10pyridinylimidazole449.5MAPK1, MAPK10
11gw-5074449.4MAPK10, MAPK1
12olomoucine44 1110.4MAPK1, NGF, MAPK10
13thapsigargin44 5910.3MAPK10, BDNF
14hcec449.2NGF, BDNF, MAPK1
15c2ceramide449.2MAPK10, NGF, MAPK1, NTRK1
16rasagiline44 1110.1NGF, MAPK10, BDNF
17gnf 5837599.1NGF, NGFR, NTRK1, BDNF
18tlqp 21599.1NGF, NTRK1, NGFR, BDNF
19nmda44 2810.1MAPK10, NGF, BDNF
20bdnf (human)599.1BDNF, NTRK1, NGF, NGFR
21ana 12599.1NGF, BDNF, NTRK1, NGFR
227,8-dihydroxyflavone44 5910.1BDNF, NGF, NGFR, NTRK1
23capsaicin44 2810.1BDNF, NTRK1, NGF
24phorbol449.0NTRK1, MAPK10, MAPK1, NGFR
25choline44 11 2411.0NTRK1, BDNF, NGF, NGFR
26phenylalanine449.0BDNF, PKLR, NGFR
27bisindolylmaleimide448.8MAPK1, BDNF, MAPK10
28phosphotyrosine448.8NGF, NGFR, NTRK1, MAPK10, MAPK1
2912-o-tetradecanoylphorbol 13-acetate448.8NGFR, NGF, MAPK1, NTRK1, MAPK10
30anisomycin44 119.6MAPK10, NGF, MAPK1, BDNF
31matrigel448.6BDNF, NTRK1, MAPK1, NGFR, NGF
32ceramide448.5MAPK10, GLA, NTRK1, MAPK1, NGFR, NGF
33acetylcholine44 49 28 11 2412.4BDNF, NTRK1, MAPK10, NGFR, NGF
34pd 98,059448.3NGF, MAPK1, MAPK10, NTRK1, BDNF
35ly294002448.3MAPK10, MAPK1, NGF, NTRK1, BDNF
36cyclic amp44 249.3BDNF, NTRK1, NGF, MAPK10, NGFR
37adenylate448.2NTRK1, MAPK1, BDNF, NGF, MAPK10
38glutamate448.2NGF, NGFR, MAPK1, GLA, BDNF, NTRK1
39cycloheximide448.1NGF, MAPK1, BDNF, NTRK1, MAPK10
40thymidine44 249.1MAPK10, NGF, NGFR, MAPK1, BDNF
41arachidonic acid44 28 11 2411.1ALOX12B, MAPK10, BDNF, ALOXE3, NTRK1, NGFR
42k252a448.0NTRK1, MAPK10, MAPK1, NGFR, NGF, BDNF
43threonine448.0GLA, NTRK1, MAPK10, MAPK1, NGFR, NGF
44wortmannin448.0NTRK1, MAPK1, BDNF, MAPK10, NGFR, NGF
45phosphoinositide448.0MAPK10, NTRK1, NGF, NGFR, MAPK1, BDNF
46vegf447.9BDNF, MAPK10, MAPK1, NGFR, NGF, NTRK1
47phosphatidylinositol447.9BDNF, NGFR, MAPK1, MAPK10, NGF, NTRK1
48retinoic acid44 248.8MAPK10, NGF, NGFR, MAPK1, NTRK1, BDNF
49h2o2447.6BDNF, NTRK1, MAPK10, MAPK1, ALOX12B
50tyrosine447.2NGF, NGFR, MAPK1, NTRK1, MAPK10, PKLR

GO Terms for genes affiliated with Anhidrosis

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Sources:
16Gene Ontology
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Cellular components related to Anhidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:0057689.5NGF, NGFR, NTRK1

Biological processes related to Anhidrosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1establishment of skin barrierGO:06143610.1ALOX12B, ALOXE3
2hepoxilin biosynthetic processGO:05112210.1ALOXE3, ALOX12B
3response to electrical stimulusGO:05160210.0NGF, NTRK1
4linoleic acid metabolic processGO:04365110.0ALOX12B, ALOXE3
5regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432819.9NGFR, NGF
6lipoxygenase pathwayGO:0193729.9ALOXE3, ALOX12B
7positive regulation of axonogenesisGO:0507729.8NGF, NGFR
8regulation of axonogenesisGO:0507709.8NGF, NGFR
9sphingolipid metabolic processGO:0066659.7GLA, ALOX12B, ALOXE3
10activation of MAPKK activityGO:0001869.7NGF, MAPK1, NTRK1
11mechanoreceptor differentiationGO:0424909.7NTRK1, BDNF
12Ras protein signal transductionGO:0072659.7NTRK1, MAPK1, NGF
13ceramide biosynthetic processGO:0465139.7ALOX12B, ALOXE3
14response to radiationGO:0093149.6NGF, NTRK1
15sensory perception of painGO:0192339.6ALOXE3, NGF, MAPK1
16nerve developmentGO:0216759.4BDNF, NGFR
17negative regulation of neuron apoptotic processGO:0435249.3NGF, NTRK1, BDNF
18neurotrophin TRK receptor signaling pathwayGO:0480119.2NGF, NGFR, MAPK1, NTRK1
19axon guidanceGO:0074118.7BDNF, NTRK1, MAPK1, NGFR

Molecular functions related to Anhidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenGO:0167029.8ALOXE3, ALOX12B
2nerve growth factor bindingGO:0484069.5NGFR, NTRK1

Products for genes affiliated with Anhidrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anhidrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet