MCID: ANH002
MIFTS: 48

Anhidrosis malady

Skin category

Summaries for Anhidrosis

Sources:
47OMIM, 33MalaCards
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MalaCards: Anhidrosis, also known as absence of sweating, is related to autonomic neuropathy and hypohidrosis. An important gene associated with Anhidrosis is NTRK1 (neurotrophic tyrosine kinase, receptor, type 1), and among its related pathways are Thyroid cancer and p75NTR signals via NF-kB. The compounds forskolin and serine have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and lung, and related mouse phenotypes are integument and no phenotypic analysis.

Description from OMIM:47 206600

Aliases & Classifications for Anhidrosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 47OMIM, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

anhidrosis 8 10 45 61
absence of sweating 8
adiaphoresis 8


External Ids:

Disease Ontology8 DOID:11156
MeSH35 D007007
NCIt40 C34385
OMIM47 206600
ICD9CM27 705.0
ICD1025 L74.4

Related Diseases for Anhidrosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Anhidrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1autonomic neuropathy30.4IKBKAP, NGF, NTRK1
2hypohidrosis30.3GLA
3pyruvate kinase deficiency29.8PKLR
4atopic dermatitis29.8NGF, NGFR, BDNF
5hereditary sensory and autonomic neuropathy iv10.6
6horner's syndrome10.2
7alopecia10.2
8pain disorder10.2
9n syndrome10.1
10ectodermal dysplasia10.1
11sialadenitis10.0
12cholinergic urticaria10.0
13fabry disease10.0
14adie syndrome10.0
15urticaria10.0
16vasculitis10.0
17bod syndrome10.0
18harlequin syndrome10.0
19postural hypotension10.0
20congenital horner syndrome10.0
21chagas disease10.0NTRK1
22peripheral neuropathy10.0NTRK1
23phaeochromocytoma10.0NGF
24myocardial infarction10.0GLA
25ependymoma10.0NGFR
26neuroaxonal dystrophy10.0NTRK1, NGF
27acute leukemia10.0MAPK10
28down syndrome10.0MAPK10
29allergic rhinitis10.0NGFR, NGF
30prolactinoma10.0NGF, NGFR
31neuropathy10.0NGF, IKBKAP
32diabetes mellitus10.0PKLR, NGF
33pancreatitis10.0MAPK10
34autosomal recessive congenital ichthyosis10.0ALOXE3, ALOX12B
35hyperglycemia10.0BDNF
36diabetic neuropathy10.0NGF, NGFR, NTRK1
37ganglioneuroma10.0NGF, NGFR, NTRK1
38attention deficit hyperactivity disorder10.0BDNF
39hereditary sensory neuropathy10.0NTRK1, NGF, IKBKAP
40cannabis abuse10.0NGF, BDNF
41gaucher's disease10.0GLA, PKLR
42myopathy10.0IKBKAP, NGF, PKLR
43papillary thyroid carcinoma10.0NTRK1, MAPK10
44congenital ichthyosiform erythroderma10.0ALOXE3, ALOX12B
45toxic encephalopathy10.0NGF, BDNF
46asthma10.0NGFR, NGF, IKBKAP
47sensory peripheral neuropathy10.0NGF, NTRK1, BDNF
48hepatocellular carcinoma10.0BDNF, MAPK1
49rett syndrome10.0NGF, NTRK1, BDNF
50neuroepithelioma10.0MAPK10, MAPK1, NGF

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to anhidrosis

Clinical Features for Anhidrosis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

206600

Drugs & Therapeutics for Anhidrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anhidrosis

Drug clinical trials:

Search ClinicalTrials for Anhidrosis

Search NIH Clinical Center for Anhidrosis

Search CenterWatch for Anhidrosis

Genetic Tests for Anhidrosis

Anatomical Context for Anhidrosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anhidrosis:

33
Skin, Spinal cord, Lung, T cells, B cells

Animal Models for Anhidrosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Anhidrosis

Sources:
51PubMed
See all sources

Articles related to Anhidrosis:

(show top 50)    (show all 248)
idTitleAuthorsYear
1
Old fractures in two patients with congenital insensitivity to pain with anhidrosis: radiological findings. (23478071)
2013
2
Congenital Insensitivity to Pain with Anhidrosis (CIPA): A Case Report. (22737448)
2011
3
Four cases of atopic dermatitis complicated by SjAPgren's syndrome: link between dry skin and autoimmune anhidrosis. (21364310)
2011
4
A case of lung cancer with unilateral anhidrosis and contralateral hyperhidrosis as the first clinical manifestation. (21763575)
2011
5
Risk of aspiration during anesthesia in patients with congenital insensitivity to pain with anhidrosis: case reports and review of the literature. (20632040)
2010
6
An epidemiologic study of anhidrosis in horses in Florida. (20470071)
2010
7
Isolated generalised anhidrosis induced by postganglionic sympathetic skin nerve fibre degeneration: an incomplete Ross syndrome? (18356251)
2008
8
Dental management of oral self-mutilation in neurological patients: a case of congenital insensitivity to pain with anhidrosis. (18830173)
2008
9
Identification of subgroups of acquired idiopathic generalized anhidrosis. (18784603)
2008
10
Equine sweating and anhidrosis Part 2: anhidrosis. (17222233)
2007
11
Equine sweating and anhidrosis Part 1--equine sweating. (17083570)
2006
12
A novel lymphocyte signaling defect: trk A mutation in the syndrome of congenital insensitivity to pain and anhidrosis (CIPA). (15163901)
2004
13
Acquired generalized anhidrosis associated with lymphocytic infundibuloneurohypophysitis. (15534277)
2004
14
Congenital insensitivity to pain with anhidrosis: a case report. (14626720)
2003
15
Post-herpetic neuralgia in a patient with congenital insensitivity to pain and anhidrosis. (14566502)
2002
16
Indolent corneal ulcers in a patient with congenital insensitivity to pain with anhidrosis: a case report and literature review. (11936447)
2002
17
Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome. (12210801)
2002
18
Neurophysiologic studies in congenital insensitivity to pain with anhidrosis. (11744315)
2001
19
Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency. (11668614)
2001
20
Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli- Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. (10861667)
2000
21
Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with congenital insensitivity to pain with anhidrosis. (11071380)
2000
22
Oral prednisolone improved acetylcholine-induced sweating in SjAPgren's syndrome-related anhidrosis. (11055832)
2000
23
Congenital insensitivity to pain with anhidrosis: report of a 68-day-old case. (10094459)
1999
24
Idiopathic acquired anhidrosis: reversible generalized anhidrosis after sunstroke. (10535259)
1999
25
A female patient with the Rothmund-Thomson syndrome associated with anhidrosis and severe infections of the respiratory tract. (9568421)
1998
26
Hereditary insensitivity to pain with anhidrosis. (9806143)
1998
27
Congenital insensitivity to pain and anhidrosis with mitochondrial and axonal abnormalities. (9436803)
1997
28
Skin sympathetic nerve activity in acquired idiopathic generalized anhidrosis. (8170558)
1993
29
Familial generalized anhidrosis. (2401613)
1990
30
Familial generalized anhidrosis. (2401610)
1990
31
Anhidrosis (hypohidrosis) in SjAPgren's syndrome. (3819059)
1987
32
Case report: multiagent chemotherapy of Hodgkin's disease associated with red cell aplasia, acquired ichthyosis and anhidrosis. (3125033)
1987
33
Congenital insensitivity to pain with anhidrosis: morphological and morphometrical studies on the skin and peripheral nerves. (2425284)
1986
34
Chronic idiopathic anhidrosis. (4051460)
1985
35
Permanent local anaesthesia and anhidrosis after clove oil spillage. (6132216)
1983
36
Anhidrosis with anisocoria: clinical and autonomic evaluation. (6303663)
1983
37
Equine anhidrosis: a survey of affected horses in Florida. (7068500)
1982
38
Progressive isolated segmental anhidrosis. (7065936)
1982
39
Studies on the mechanism of topical anhidrosis due to polyvalent cations. (19469924)
1981
40
Anhidrosis manifesting as low grade pyrexia (cas report). (511835)
1979
41
Congenital sensory neuropathy with anhidrosis: a case report. (1250661)
1976
42
Congenital sensory neuropathy with anhidrosis: orthopedic complication and management. (60189)
1976
43
Idiopathic chronic orthostatic hypotension associated with anhidrosis, impotence and changing pulse (cardiac arrhythmia). A case report and review of subject. (4655519)
1972
44
Patchy alopecia, anhidrosis, eccrine gland wall hypertrophy and vasculitis. (5477063)
1970
45
Miliaria and anhidrosis. I. Experimental production in volunteers. (6062874)
1967
46
Observations on experimental anhidrosis. (14441733)
1960
47
Simple methods of testing for hypohidrosis and anhidrosis in leprosy patients in the tropics. (13850409)
1960
48
Anhidrotic ectodermal dysplasia: use of the silver nitrate plate to detect anhidrosis. (13611610)
1959
49
Anhidrosis. An etiologic interpretation. (14779746)
1950
50
Acquired generalized anhidrosis with localized hyperhidrosis. (21013497)
1946

Genetic Variations for Anhidrosis

Expression for genes affiliated with Anhidrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anhidrosis

Search GEO for disease gene expression data for Anhidrosis.

Pathways for genes affiliated with Anhidrosis

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 52QIAGEN, 50PharmGKB, 60Tocris Bioscience, 38NCBI BioSystems Database, 56SinoBiological, 53R&D Systems
See all sources

Pathways related to Anhidrosis according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2NTRK1
2
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10.2NGF
3
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9.9NTRK1, NGF
4
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9.9NTRK1, NGF
59.8NGFR, NGF
6
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9.8NGFR, NGF
7
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9.8NGF, NGFR
89.8NGFR, NGF
9
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9.8ALOX12B, ALOXE3
10
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9.7BDNF
11
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9.4NGF, MAPK1, NTRK1
12
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9.4NTRK1, MAPK1, NGF
13
Hide members
9.4NGF, MAPK1, NTRK1
14
Hide members
9.4NTRK1, MAPK1, NGF
159.3MAPK1, MAPK10
16
Hide members
9.3MAPK1, MAPK10
17
Hide members
9.3MAPK1, MAPK10
18
Hide members
9.2NGFR, MAPK10, NTRK1
19
Hide members
9.2NGFR, MAPK10, NTRK1
209.1MAPK1, BDNF
21
Hide members
9.0MAPK1, MAPK10, PKLR
229.0NGFR, NTRK1, BDNF
23
Hide members
9.0NGF, NGFR, MAPK1, NTRK1
24
Hide members
8.9BDNF, NGFR, NGF
25
Hide members
8.9MAPK10, MAPK1, NGFR
268.9BDNF, NTRK1, MAPK1
27
Hide members
8.8NGF, MAPK1, MAPK10, NTRK1
288.7BDNF, MAPK1, NGFR
298.7NGF, NGFR, NTRK1, BDNF
30
Hide members
8.7NTRK1, MAPK10, MAPK1, NGFR
31
Hide members
8.5BDNF, MAPK10, MAPK1
32
Hide members
8.5BDNF, NTRK1, MAPK1, NGFR
33
Hide members
8.5NGFR, MAPK1, NTRK1, BDNF
34
Hide members
8.5BDNF, NTRK1, MAPK1, NGFR
358.3BDNF, MAPK10, NGFR, NGF
36
Hide members
8.2BDNF, NTRK1, MAPK10, MAPK1
37
Hide members
8.2BDNF, PKLR, MAPK10, MAPK1
388.2BDNF, NTRK1, MAPK1, NGFR, NGF
39
Hide members
8.1BDNF, MAPK10, MAPK1, NGFR
40
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7.9NGF, MAPK1, MAPK10, NTRK1, BDNF
41
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
42
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
43
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
44
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
45
Hide members
7.8BDNF, NTRK1, MAPK10, MAPK1, NGFR
46
Hide members
7.5NGF, NGFR, MAPK1, MAPK10, NTRK1, BDNF
477.5NGF, NGFR, MAPK1, MAPK10, NTRK1, BDNF

Compounds for genes affiliated with Anhidrosis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Anhidrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1forskolin45 50 1112.4NGFR
2serine4510.3PKLR, GLA
3cipa4510.2NTRK1, NGF
412(r)-hpete45 2411.1ALOX12B, ALOXE3
5ag 879459.7NTRK1, NGF, MAPK10
6estradiol valerate459.7NGFR, NGF
7gnrh459.6BDNF, NTRK1
8ganglioside459.6GLA, NGF, NGFR, NTRK1
91,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene459.5MAPK1, MAPK10
10pyridinylimidazole459.5MAPK1, MAPK10
11gw-5074459.4MAPK10, MAPK1
12olomoucine45 1110.4MAPK1, NGF, MAPK10
13thapsigargin45 6010.3MAPK10, BDNF
14hcec459.2NGF, BDNF, MAPK1
15c2ceramide459.2MAPK10, NGF, MAPK1, NTRK1
16rasagiline45 1110.1NGF, MAPK10, BDNF
17gnf 5837609.1NGF, NGFR, NTRK1, BDNF
18tlqp 21609.1NGF, NTRK1, NGFR, BDNF
19nmda45 2910.1MAPK10, NGF, BDNF
20bdnf (human)609.1BDNF, NTRK1, NGF, NGFR
21ana 12609.1NGF, BDNF, NTRK1, NGFR
227,8-dihydroxyflavone45 6010.1BDNF, NGF, NGFR, NTRK1
23capsaicin45 2910.1BDNF, NTRK1, NGF
24phorbol459.0NTRK1, MAPK10, MAPK1, NGFR
25choline45 11 2411.0NTRK1, BDNF, NGF, NGFR
26phenylalanine459.0BDNF, PKLR, NGFR
27bisindolylmaleimide458.8MAPK1, BDNF, MAPK10
28phosphotyrosine458.8NGF, NGFR, NTRK1, MAPK10, MAPK1
2912-o-tetradecanoylphorbol 13-acetate458.8NGFR, NGF, MAPK1, NTRK1, MAPK10
30anisomycin45 119.6MAPK10, NGF, MAPK1, BDNF
31matrigel458.6BDNF, NTRK1, MAPK1, NGFR, NGF
32ceramide458.5MAPK10, GLA, NTRK1, MAPK1, NGFR, NGF
33acetylcholine45 50 29 11 2412.4BDNF, NTRK1, MAPK10, NGFR, NGF
34pd 98,059458.3NGF, MAPK1, MAPK10, NTRK1, BDNF
35ly294002458.3MAPK10, MAPK1, NGF, NTRK1, BDNF
36cyclic amp45 249.3BDNF, NTRK1, NGF, MAPK10, NGFR
37adenylate458.2NTRK1, MAPK1, BDNF, NGF, MAPK10
38glutamate458.2NGF, NGFR, MAPK1, GLA, BDNF, NTRK1
39cycloheximide458.1NGF, MAPK1, BDNF, NTRK1, MAPK10
40thymidine45 249.1MAPK10, NGF, NGFR, MAPK1, BDNF
41arachidonic acid45 29 11 2411.1ALOX12B, MAPK10, BDNF, ALOXE3, NTRK1, NGFR
42k252a458.0NTRK1, MAPK10, MAPK1, NGFR, NGF, BDNF
43threonine458.0GLA, NTRK1, MAPK10, MAPK1, NGFR, NGF
44wortmannin458.0NTRK1, MAPK1, BDNF, MAPK10, NGFR, NGF
45phosphoinositide458.0MAPK10, NTRK1, NGF, NGFR, MAPK1, BDNF
46vegf457.9BDNF, MAPK10, MAPK1, NGFR, NGF, NTRK1
47phosphatidylinositol457.9BDNF, NGFR, MAPK1, MAPK10, NGF, NTRK1
48retinoic acid45 248.8MAPK10, NGF, NGFR, MAPK1, NTRK1, BDNF
49h2o2457.6BDNF, NTRK1, MAPK10, MAPK1, ALOX12B
50tyrosine457.2NGF, NGFR, MAPK1, NTRK1, MAPK10, PKLR

GO Terms for genes affiliated with Anhidrosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Anhidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:0057689.5NGF, NGFR, NTRK1

Biological processes related to Anhidrosis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1establishment of skin barrierGO:06143610.1ALOX12B, ALOXE3
2hepoxilin biosynthetic processGO:05112210.1ALOXE3, ALOX12B
3response to electrical stimulusGO:05160210.0NGF, NTRK1
4linoleic acid metabolic processGO:04365110.0ALOX12B, ALOXE3
5regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:0432819.9NGFR, NGF
6lipoxygenase pathwayGO:0193729.9ALOXE3, ALOX12B
7positive regulation of axonogenesisGO:0507729.8NGF, NGFR
8regulation of axonogenesisGO:0507709.8NGF, NGFR
9sphingolipid metabolic processGO:0066659.7GLA, ALOX12B, ALOXE3
10activation of MAPKK activityGO:0001869.7NGF, MAPK1, NTRK1
11mechanoreceptor differentiationGO:0424909.7NTRK1, BDNF
12Ras protein signal transductionGO:0072659.7NTRK1, MAPK1, NGF
13ceramide biosynthetic processGO:0465139.7ALOX12B, ALOXE3
14response to radiationGO:0093149.6NGF, NTRK1
15sensory perception of painGO:0192339.6ALOXE3, NGF, MAPK1
16nerve developmentGO:0216759.4BDNF, NGFR
17negative regulation of neuron apoptotic processGO:0435249.3NGF, NTRK1, BDNF
18neurotrophin TRK receptor signaling pathwayGO:0480119.2NGF, NGFR, MAPK1, NTRK1
19axon guidanceGO:0074118.7BDNF, NTRK1, MAPK1, NGFR

Molecular functions related to Anhidrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenGO:0167029.8ALOXE3, ALOX12B
2nerve growth factor bindingGO:0484069.5NGFR, NTRK1

Products for genes affiliated with Anhidrosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anhidrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet