Aliases & Classifications for Anhidrosis

Aliases & Descriptions for Anhidrosis:

Name: Anhidrosis 12 52 14 69
Absence of Sweating 12
Adiaphoresis 12

Classifications:



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Disease Ontology 12 DOID:11156
ICD10 33 L74.4
ICD9CM 35 705.0
MeSH 42 D007007
NCIt 47 C34385
UMLS 69 C0003028

Summaries for Anhidrosis

MalaCards based summary : Anhidrosis, also known as absence of sweating, is related to insensitivity to pain, congenital, with anhidrosis and anhidrosis, isolated, with normal sweat glands, and has symptoms including increased sweating An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways/superpathways are GPCR Pathway and TGF-Beta Pathway. Affiliated tissues include skin, testes and lung, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 71 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

Related Diseases for Anhidrosis

Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
id Related Disease Score Top Affiliating Genes
1 insensitivity to pain, congenital, with anhidrosis 12.3
2 anhidrosis, isolated, with normal sweat glands 12.2
3 harlequin syndrome 11.4
4 hypohidrosis 11.3
5 horner's syndrome 11.1
6 van den bosch syndrome 10.8
7 ichthyosis, congenital, autosomal recessive 11 10.7
8 ichthyosis, congenital, autosomal recessive 7 10.7
9 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.7
10 immunodeficiency 9 10.7
11 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.7
12 ichthyosis, congenital, autosomal recessive 1 10.7
13 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.7
14 ichthyosis, congenital, autosomal recessive 9 10.7
15 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 10.7
16 ichthyosis, congenital, autosomal recessive 2 10.7
17 ichthyosis, congenital, autosomal recessive 4a 10.7
18 ichthyosis, congenital, autosomal recessive 3 10.7
19 ichthyosis, congenital, autosomal recessive 5 10.7
20 ectodermal dysplasia 1, hypohidrotic, x-linked 10.7
21 ichthyosis, congenital, autosomal recessive 6 10.7
22 ichthyosis, congenital, autosomal recessive 10 10.7
23 splenomegaly, cytopenia, and vision loss 10.7
24 ichthyosis, congenital, autosomal recessive 8 10.7
25 horner syndrome, congenital 10.7
26 neuropathy 10.3
27 gall bladder carcinoma in situ 10.2 NGF NTRK1
28 lung occult small cell carcinoma 10.2 NGF NTRK1
29 hypermobility of coccyx 10.1 NGF NGFR
30 appendix carcinoid tumor 10.1 NGF NTRK1
31 pseudoinflammatory fundus dystrophy 10.1 NGF NGFR
32 auriculocondylar syndrome 1 10.1 NGF NTRK1
33 ampulla of vater mucinous adenocarcinoma 10.1 NGFR NTRK1
34 walker-warburg syndrome 10.1 NGF NTRK1
35 dilated cardiomyopathy 10.0 NGF NGFR NTRK1
36 scleroperikeratitis 10.0 GLA NGF NTRK1
37 autonomic neuropathy 10.0
38 pheochromocytoma 10.0 NGF NGFR NTRK1
39 ascariasis 10.0 NGFR NTRK3
40 gaucher disease, type ii 10.0 GLA PKLR
41 adenosine triphosphate, elevated, of erythrocytes 9.9 NTRK1 PKLR
42 alopecia 9.9
43 ectodermal dysplasia 9.9
44 miliaria 9.9
45 pallister-hall syndrome 9.9 NGF NTRK1 NTRK3
46 cholinergic urticaria 9.8
47 urticaria 9.8
48 dermatitis 9.8
49 headache 9.8
50 multiple system atrophy 9.8

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to Anhidrosis

Symptoms & Phenotypes for Anhidrosis

UMLS symptoms related to Anhidrosis:


increased sweating

MGI Mouse Phenotypes related to Anhidrosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.01 CHRM3 GLA IKBKG ITPR2 NGF NGFR
2 growth/size/body region MP:0005378 9.92 NTRK1 NTRK3 CHRM3 GLA IKBKG ITPR2
3 cardiovascular system MP:0005385 9.91 CHRM3 GLA IKBKG ITPR2 NGF NGFR
4 mortality/aging MP:0010768 9.86 GLA IKBKG ITPR2 NGF NGFR NTRK1
5 muscle MP:0005369 9.55 CHRM3 GLA NGF NGFR NTRK1
6 normal MP:0002873 9.5 IKBKG ITPR2 NGF NGFR NTRK1 NTRK3
7 vision/eye MP:0005391 9.1 CHRM3 GLA NGF NGFR NTRK1 NTRK3

Drugs & Therapeutics for Anhidrosis

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2

Search NIH Clinical Center for Anhidrosis

Genetic Tests for Anhidrosis

Anatomical Context for Anhidrosis

MalaCards organs/tissues related to Anhidrosis:

39
Skin, Testes, Lung, T Cells, Neutrophil, Bone, Spinal Cord

Publications for Anhidrosis

Articles related to Anhidrosis:

(show top 50) (show all 292)
id Title Authors Year
1
Mutations in TrkA causing congenital insensitivity to pain with anhidrosis (CIPA) induce misfolding, aggregation and mutation-dependent neurodegeneration by dysfunction of the autophagic flux. ( 27551041 )
2016
2
Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction. ( 27859565 )
2016
3
Raeder's Paratrigeminal Syndrome: Headache and Horner's Lacking Anhidrosis. ( 26902244 )
2016
4
Orthopaedic manifestations of congenital indifference to pain with anhidrosis (Hereditary Sensory and Autonomic Neuropathy type IV). ( 27637569 )
2016
5
Unilateral anhidrosis: A rare complication of thoracic epidural analgesia. ( 26612960 )
2016
6
Congenital insensitivity to pain with anhidrosis: A report of two siblings with a novel mutation in (TrkA) NTRK1 gene in a Saudi family. ( 27772781 )
2016
7
Generalised Anhidrosis Secondary to Intracranial Haemorrhage. ( 27125348 )
2016
8
Harlequin syndrome with contralateral anhidrosis after an upper chest gunshot wound. ( 27535737 )
2016
9
Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan. ( 27774633 )
2016
10
Idiopathic segmental anhidrosis associated with varicella. ( 27206820 )
2016
11
Anesthetic considerations in a parturient with congenital insensitivity to pain with anhidrosis. ( 27884666 )
2016
12
Clinical Analysis and Management of Acquired Idiopathic Generalized Anhidrosis. ( 27584965 )
2016
13
Congenital Insensitivity to Pain and Anhidrosis. ( 26848454 )
2016
14
Congenital insensitivity to pain and anhidrosis: Case report and review of findings along neuro-immune axis in the disorder. ( 27772759 )
2016
15
Phenotypes and Genotypes in Five Children with Congenital Insensitivity to Pain with Anhidrosis. ( 27265460 )
2016
16
A Girl with No Pain: Congenital Insensitivity To Pain and Anhidrosis (HSAN) Type IV - A Case Report. ( 27042602 )
2016
17
Purple hands in multiple system atrophy: Global anhidrosis with preserved acral sweating. ( 27298449 )
2016
18
Genetic Disorders with Dyshidrosis: Ectodermal Dysplasia, Incontinentia Pigmenti, Fabry Disease, and Congenital Insensitivity to Pain with Anhidrosis. ( 27584961 )
2016
19
Acquired anhidrosis in a case of autoimmune autonomic ganglionopathy. ( 27774700 )
2016
20
Update Review and Clinical Presentation in Congenital Insensitivity to Pain and Anhidrosis. ( 26579324 )
2015
21
Anesthetic Management of Patients with Congenital Insensitivity to Pain with Anhidrosis: A Retrospective Analysis of 358 Procedures Performed Under General Anesthesia. ( 26484462 )
2015
22
Norepinephrine deficiency with normal blood pressure control in congenital insensitivity to pain with anhidrosis. ( 25627679 )
2015
23
Novel and novel de novo mutations in NTRK1 associated with congenital insensitivity to pain with anhidrosis: a case report. ( 25984678 )
2015
24
A lady presenting with segmental anhidrosis and heat intolerance. ( 25821738 )
2015
25
Correlation of disease activity and serum level of carcinoembryonic antigen in acquired idiopathic generalized anhidrosis: A case report. ( 25958966 )
2015
26
Congenital insensitivity to pain with anhidrosis. ( 26032179 )
2015
27
Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum CEA level and disease activity. ( 26446433 )
2015
28
Acquired Idiopathic Generalized Anhidrosis. ( 26288446 )
2015
29
Congenital Insensitivity to Pain with Anhidrosis in Twin Sisters with Sensorineural Deafness. ( 25776000 )
2015
30
Therapeutic effects and prevention of recurrence of acquired idiopathic generalized anhidrosis via i.v. immunoglobulin treatment. ( 26508392 )
2015
31
Combined cholinergic urticaria and cold-induced cholinergic urticaria with acquired idiopathic generalized anhidrosis. ( 25838106 )
2015
32
Congenital Insensitivity to Pain without Anhidrosis: Orodental Problems and Management. ( 26457210 )
2015
33
Decreased expression of acetylcholine esterase in cholinergic urticaria with hypohidrosis or anhidrosis. ( 23748235 )
2014
34
Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis. ( 25060903 )
2014
35
Congenital insensitivity to pain and anhidrosis syndrome: two cases involving a brother and sister. ( 25421205 )
2014
36
A novel NTRK1 mutation in a patient with congenital insensitivity to pain with anhidrosis. ( 25519000 )
2014
37
A case of congenital insensitivity to pain with anhidrosis. ( 26078659 )
2014
38
Acquired idiopathic anhidrosis: a diagnosis often missed. ( 24856478 )
2014
39
Skeletal complications in congenital insensitivity to pain with anhidrosis: a case series of 14 patients and review of articles published in Japanese. ( 24953503 )
2014
40
Correlating interleukin-12 stimulated interferon-I^ production and the absence of ectodermal dysplasia and anhidrosis (EDA) in patients with mutations in NF-I_B essential modulator (NEMO). ( 24682681 )
2014
41
A case of acquired idiopathic generalized anhidrosis in a 2-year-old infant. ( 24698553 )
2014
42
Partial anhidrosis demonstrated by Q-SART in a patient with a novel mutation in the EDARADD gene. ( 24666190 )
2014
43
Novel NTRK1 Frameshift Mutation in Congenital Insensitivity to Pain With Anhidrosis. ( 25316729 )
2014
44
Photoletter to the editor: Acquired idiopathic generalized anhidrosis. ( 25621094 )
2014
45
Two cases of acquired idiopathic generalized anhidrosis successfully treated by steroid pulse therapy. ( 24801920 )
2014
46
Acquired Idiopathic Generalized Anhidrosis: An Immunohistopathological Investigation of Peri-glands Infiltrated with Immunoreactive Cells. ( 25519938 )
2014
47
Holocord syrinx presenting as hemi anhidrosis. ( 23741667 )
2013
48
Oral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosis. ( 23799134 )
2013
49
Variation of muscular structure in congenital insensitivity to pain and anhidrosis. ( 23498566 )
2013
50
Generalized anhidrosis. ( 23545621 )
2013

Variations for Anhidrosis

Expression for Anhidrosis

Search GEO for disease gene expression data for Anhidrosis.

Pathways for Anhidrosis

Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 IKBKG ITPR2 NGF NGFR NTRK1 NTRK3
2
Show member pathways
13.26 IKBKG ITPR2 NGF NGFR NTRK1 NTRK3
3
Show member pathways
13.17 IKBKG NGF NGFR NTRK1 NTRK3
4
Show member pathways
13.07 ITPR2 NGF NGFR NTRK1 NTRK3
5
Show member pathways
13.05 IKBKG NGF NGFR NTRK1 NTRK3
6
Show member pathways
12.8 ITPR2 NGF NGFR NTRK1 NTRK3
7
Show member pathways
12.64 IKBKG ITPR2 NTRK1 NTRK3
8
Show member pathways
12.61 IKBKG ITPR2 NGF NGFR NTRK1 NTRK3
9
Show member pathways
12.56 IKBKG ITPR2 NGF NTRK1
10
Show member pathways
12.56 NGF NGFR NTRK1 NTRK3
11
Show member pathways
12.47 IKBKG ITPR2 NGF NGFR NTRK1
12
Show member pathways
12.39 IKBKG ITPR2 NGF NGFR
13
Show member pathways
12.39 NGF NGFR NTRK1 NTRK3
14 12.31 NGF NGFR NTRK1 NTRK3
15
Show member pathways
12.16 CHRM3 ITPR2 PKLR
16
Show member pathways
12.16 IKBKG NGFR NTRK1 NTRK3
18
Show member pathways
11.8 IKBKG NGF NGFR NTRK1
19 11.52 NGF NGFR NTRK1 NTRK3
20
Show member pathways
11.5 IKBKG NGF NGFR
21 11.47 ITPR2 NGF NTRK1 NTRK3
22
Show member pathways
11.4 IKBKG NGF NGFR
23 11.29 NTRK1 NTRK3
24 11.18 IKBKG NGF NGFR NTRK1 NTRK3
25 11.12 NGF NGFR
26
Show member pathways
11.04 NGF NGFR NTRK1 NTRK3
27
Show member pathways
10.57 NGF NTRK1

GO Terms for Anhidrosis

Cellular components related to Anhidrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 ITPR2 NTRK1 NTRK3

Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.71 CHRM3 NGFR NTRK1 NTRK3
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.5 NGF NTRK1 NTRK3
3 negative regulation of neuron death GO:1901215 9.49 IKBKG NTRK1
4 activation of MAPKK activity GO:0000186 9.48 NGF NTRK1
5 response to axon injury GO:0048678 9.46 NTRK1 NTRK3
6 positive regulation of axonogenesis GO:0050772 9.43 NGF NGFR
7 positive regulation of Ras protein signal transduction GO:0046579 9.37 NGF NTRK1
8 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.26 NGF NGFR
9 mechanoreceptor differentiation GO:0042490 9.16 NTRK1 NTRK3
10 neurotrophin signaling pathway GO:0038179 8.96 NTRK1 NTRK3
11 neurotrophin TRK receptor signaling pathway GO:0048011 8.8 NGF NGFR NTRK1

Molecular functions related to Anhidrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.32 NTRK1 NTRK3
2 GPI-linked ephrin receptor activity GO:0005004 9.26 NTRK1 NTRK3
3 nerve growth factor binding GO:0048406 9.16 NGFR NTRK1
4 neurotrophin receptor activity GO:0005030 8.96 NTRK1 NTRK3
5 neurotrophin binding GO:0043121 8.8 NGFR NTRK1 NTRK3

Sources for Anhidrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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