Aliases & Classifications for Anhidrosis

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Aliases & Descriptions for Anhidrosis:

Name: Anhidrosis 11 49 13 67
Absence of Sweating 11
 
Adiaphoresis 11

Classifications:



External Ids:

Disease Ontology11 DOID:11156
ICD1029 L74.4
ICD9CM31 705.0
MeSH38 D007007
NCIt44 C34385

Summaries for Anhidrosis

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Wikipedia:70 Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a... more...

MalaCards based summary: Anhidrosis, also known as absence of sweating, is related to pyruvate kinase deficiency and insensitivity to pain, congenital, with anhidrosis, and has symptoms including increased sweating, cold sweat and night sweats. An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways are Activation of TRKA receptors and 14-3-3 and Regulation of BAD Activity. Affiliated tissues include skin, testes and t cells, and related mouse phenotypes are integument and muscle.

Related Diseases for Anhidrosis

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Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1pyruvate kinase deficiency29.5NTRK1, PKLR
2insensitivity to pain, congenital, with anhidrosis12.3
3anhidrosis, isolated, with normal sweat glands12.1
4isolated generalized anhidrosis with normal sweat glands11.8
5harlequin syndrome11.4
6hypohidrosis11.3
7horner's syndrome11.0
8van den bosch syndrome10.8
9ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive10.7
10ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant10.7
11ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.7
12ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.7
13ichthyosis, congenital, autosomal recessive 4a10.7
14ichthyosis, congenital, autosomal recessive 610.7
15ichthyosis, congenital, autosomal recessive 1010.7
16ichthyosis, congenital, autosomal recessive 810.7
17ichthyosis, congenital, autosomal recessive 1110.7
18ichthyosis, congenital, autosomal recessive 710.7
19immunodeficiency 910.7
20ichthyosis, congenital, autosomal recessive 110.7
21ichthyosis, congenital, autosomal recessive 910.7
22ichthyosis, congenital, autosomal recessive 210.7
23ichthyosis, congenital, autosomal recessive 310.7
24ichthyosis, congenital, autosomal recessive 510.7
25ectodermal dysplasia 1, hypohidrotic, x-linked10.7
26splenomegaly, cytopenia, and vision loss10.7
27horner syndrome, congenital10.7
28neuropathy, hereditary sensory and autonomic, type v10.3NGF, NTRK1
29pharynx carcinoma in situ10.3NGF, NTRK1
30c5 deficiency10.3NGF, NTRK1
31neuropathy10.3
32pseudoainhum10.2NGF, NGFR
33anal colloid adenocarcinoma10.2NGFR, NTRK1
34scleroperikeratitis10.2GLA, NTRK1
35epidermolysis bullosa simplex superficialis10.1NGF, NTRK1
36diffuse large b-cell lymphoma10.1NGF, NTRK1
37rumination disorder10.0NGF, NTRK1
38autonomic neuropathy10.0
39esophagitis10.0NGF, NGFR, NTRK1
40alopecia9.9
41ectodermal dysplasia9.9
42miliaria9.9
43pheochromocytoma9.9NGF, NGFR, NTRK1
44papillary serous adenocarcinoma9.9NGF, NTRK1
45adenosquamous cell lung carcinoma9.9NTRK1, NTRK3
46lung large cell carcinoma9.8NGFR, NTRK3
47multiple system atrophy9.8
48cholinergic urticaria9.8
49urticaria9.8
50dermatitis9.8

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to anhidrosis

Symptoms for Anhidrosis

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UMLS symptoms related to Anhidrosis:


increased sweating, cold sweat, night sweats

Drugs & Therapeutics for Anhidrosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and AnhidrosisWithdrawnNCT02624310Phase 2

Search NIH Clinical Center for Anhidrosis

Genetic Tests for Anhidrosis

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Anatomical Context for Anhidrosis

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MalaCards organs/tissues related to Anhidrosis:

35
Skin, Testes, T cells, Neutrophil, Bone, Lung, Spinal cord

Animal Models for Anhidrosis or affiliated genes

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MGI Mouse Phenotypes related to Anhidrosis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.4IKBKG, ITPR2, NGF, NGFR, NTRK1
2MP:00053698.7CHRM3, GLA, NGF, NGFR, NTRK1
3MP:00028738.3IKBKG, ITPR2, NGF, NGFR, NTRK1, NTRK3
4MP:00053857.8CHRM3, GLA, IKBKG, ITPR2, NGF, NGFR
5MP:00053767.8CHRM3, GLA, IKBKG, ITPR2, NGF, NGFR
6MP:00107687.5GLA, IKBKG, ITPR2, NGF, NGFR, NTRK1
7MP:00053867.5CHRM3, GLA, IKBKG, ITPR2, NGF, NGFR
8MP:00053787.4CHRM3, GLA, IKBKG, ITPR2, NGF, NGFR
9MP:00053917.4CHRM3, GLA, NGF, NGFR, NTRK1, NTRK3

Publications for Anhidrosis

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Articles related to Anhidrosis:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Harlequin syndrome with contralateral anhidrosis after an upper chest gunshot wound. (27535737)
2016
2
Raeder's Paratrigeminal Syndrome: Headache and Horner's Lacking Anhidrosis. (26902244)
2016
3
Purple hands in multiple system atrophy: Global anhidrosis with preserved acral sweating. (27298449)
2016
4
Unilateral anhidrosis: A rare complication of thoracic epidural analgesia. (26612960)
2016
5
Anesthetic Management of Patients with Congenital Insensitivity to Pain with Anhidrosis: A Retrospective Analysis of 358 Procedures Performed Under General Anesthesia. (26484462)
2015
6
Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis. (25060903)
2014
7
A case of congenital insensitivity to pain with anhidrosis. (26078659)
2014
8
Investigation of antimuscarinic receptor autoantibodies in patients with acquired idiopathic generalized anhidrosis. (24334576)
2013
9
Oral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosis. (23799134)
2013
10
Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis. (22653642)
2012
11
Right ptosis, anhidrosis, and miosis developed in a 49-year-old man with chronic dry cough for 2 months. (22796847)
2012
12
Congenital Insensitivity to Pain with Anhidrosis (HSAN Type IV), Extremely Rare Syndrome that Can Be Easily Missed by Bone and Joint Surgeons: A Case Report. (23429452)
2012
13
Syringolymphoid hyperplasia with alopecia and anhidrosis in a 12-year-old boy: a case report from rural south India. (21623775)
2011
14
Evaluation of nonnociceptive sensation in patients with congenital insensitivity to pain with anhidrosis. (20013280)
2010
15
Risk of aspiration during anesthesia in patients with congenital insensitivity to pain with anhidrosis: case reports and review of the literature. (20632040)
2010
16
Poikilodermia, anhidrosis, hairless body, neurogenic muscle atrophy, and recurrent hematuria: a new syndrome? (20179583)
2010
17
Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction? (18361470)
2008
18
Dental management of oral self-mutilation in neurological patients: a case of congenital insensitivity to pain with anhidrosis. (18830173)
2008
19
Spinal anesthesia in a patient with congenital insensitivity to pain with anhidrosis. (17513658)
2007
20
Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosis. (16279365)
2005
21
Congenital insensitivity to pain with Anhidrosis (NTRK1 mutation) and early onset renal disease: clinical report on three sibs with a 25-year follow-up in one of them. (16138253)
2005
22
Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission. (15505168)
2004
23
Intrasinus wood foreign body causing orbital cellulitis in congenital insensitivity to pain with anhidrosis syndrome. (14752319)
2004
24
Desflurane used in a patient with congenital insensitivity to pain with anhidrosis during septic shock. (15366409)
2004
25
Congenital insensitivity of pain with anhidrosis. (12619965)
2003
26
Post-herpetic neuralgia in a patient with congenital insensitivity to pain and anhidrosis. (14566502)
2002
27
Congenital insensitivity to pain with anhidrosis: an NGF/TrkA-related disorder. (11241480)
2001
28
Congenital insensitivity to pain with anhidrosis. (11483399)
2001
29
Congenital insensitivity to pain with anhidrosis: ocular and systemic manifestations. (10088743)
1999
30
A female patient with the Rothmund-Thomson syndrome associated with anhidrosis and severe infections of the respiratory tract. (9568421)
1998
31
Oral manifestations of hereditary sensory and autonomic neuropathy type IV. Congenital insensitivity to pain with anhidrosis. (9798226)
1998
32
Decreased CSF levels of substance P in patients with congenital sensory neuropathy with anhidrosis. (9109918)
1997
33
Possible mechanism of anhidrosis in a symptomatic female carrier of Fabry's disease: an assessment by skin sympathetic nerve activity and sympathetic skin response. (8726095)
1996
34
Unilateral loss of facial flushing and sweating with contralateral anhidrosis: harlequin syndrome or Adie's syndrome? (8292878)
1993
35
Tonic pupil, areflexia, and segmental anhidrosis: two additional cases of Ross syndrome and review of the literature. (1597691)
1992
36
Familial generalized anhidrosis. (2401613)
1990
37
Idiopathic acquired generalized anhidrosis: electron-microscopic and immunohistochemical studies and analysis of lectin-binding pattern of the cell membrane. (2721803)
1989
38
Hereditary sensory neuropathy with anhidrosis. A new family with a study of the sensory conduction velocity. (92176)
1978
39
Congenital sensory neuropathy with anhidrosis: a case report. (1250661)
1976
40
Pruritus and acquired anhidrosis. Two unusual cases. (5822371)
1969
41
Primary anhidrosis partialis. A case report. (5791208)
1969
42
Congenital sensory neuropathy with anhidrosis. (4171106)
1968
43
Diabetic anhidrosis. (5922894)
1966
44
Anhidrosis following intravenous bacterial pyrogen. (13796464)
1960
45
Anhidrotic ectodermal dysplasia: use of the silver nitrate plate to detect anhidrosis. (13611610)
1959
46
A form of ectodermal dysplasia; hypotrichosis with anhidrosis and anodontia]. (13023176)
1952
47
Orthostatic hypotension, anhidrosis, and impotence. (14936198)
1952
48
Clinical effects of exposure to heat and sunlight. II. Heat hyperpyrexia and thermogenic anhidrosis. (14935259)
1952
49
Unilateral frontal anhidrosis and miosis occurring after petrous apicectomy, Ramadier technic; report of a case. (18111208)
1948
50
A study of miliaria rubra, tropical anhidrosis and anhidrotic asthenia. (20242508)
1947

Variations for Anhidrosis

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Expression for genes affiliated with Anhidrosis

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Search GEO for disease gene expression data for Anhidrosis.

Pathways for genes affiliated with Anhidrosis

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Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8NGF, NTRK1
29.6NGF, NGFR
39.6NTRK1, NTRK3
4
Show member pathways
9.2IKBKG, NGF, NGFR
5
Show member pathways
9.2IKBKG, NGF, NGFR
6
Show member pathways
9.0IKBKG, ITPR2, NGF, NTRK1
7
Show member pathways
9.0IKBKG, ITPR2, NGF, NTRK1
8
Show member pathways
9.0CHRM3, ITPR2, PKLR
9
Show member pathways
8.9IKBKG, NGF, NGFR, NTRK1
108.9ITPR2, NGF, NTRK1, NTRK3
11
Show member pathways
8.9IKBKG, ITPR2, NGF, NGFR
12
Show member pathways
8.9IKBKG, ITPR2, NTRK1, NTRK3
13
Show member pathways
8.8NGF, NGFR, NTRK1, NTRK3
14
Show member pathways
8.8NGF, NGFR, NTRK1, NTRK3
158.8NGF, NGFR, NTRK1, NTRK3
168.8NGF, NGFR, NTRK1, NTRK3
178.8NGF, NGFR, NTRK1, NTRK3
18
Show member pathways
8.8NGF, NGFR, NTRK1, NTRK3
19
Show member pathways
8.8IKBKG, NGFR, NTRK1, NTRK3
20
Show member pathways
8.5ITPR2, NGF, NGFR, NTRK1, NTRK3
21
Show member pathways
8.5ITPR2, NGF, NGFR, NTRK1, NTRK3
22
Show member pathways
8.4IKBKG, NGF, NGFR, NTRK1, NTRK3
23
Show member pathways
8.4IKBKG, NGF, NGFR, NTRK1, NTRK3
24
Show member pathways
8.4IKBKG, NGF, NGFR, NTRK1, NTRK3
25
Show member pathways
8.0IKBKG, ITPR2, NGF, NGFR, NTRK1, NTRK3
26
Show member pathways
8.0IKBKG, ITPR2, NGF, NGFR, NTRK1, NTRK3

GO Terms for genes affiliated with Anhidrosis

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Cellular components related to Anhidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor complexGO:00432359.6ITPR2, NTRK1, NTRK3
2endosomeGO:00057689.3NGF, NGFR, NTRK1

Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1mechanoreceptor differentiationGO:004249010.2NTRK1, NTRK3
2activation of MAPKK activityGO:000018610.2NGF, NTRK1
3regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004328110.2NGF, NGFR
4positive regulation of axonogenesisGO:005077210.1NGF, NGFR
5negative regulation of neuron deathGO:190121510.1IKBKG, NTRK1
6positive regulation of synapse assemblyGO:005196510.0NTRK1, NTRK3
7positive regulation of Ras protein signal transductionGO:004657910.0NGF, NTRK1
8neurotrophin TRK receptor signaling pathwayGO:00480119.7NGF, NGFR, NTRK1
9response to axon injuryGO:00486789.6NTRK1, NTRK3
10positive regulation of synaptic transmission, glutamatergicGO:00519689.6NGFR, NTRK1
11negative regulation of neuron apoptotic processGO:00435249.3NGF, NGFR, NTRK1
12positive regulation of apoptotic processGO:00430659.2NGF, NGFR, NTRK3

Molecular functions related to Anhidrosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nerve growth factor bindingGO:00484069.7NGFR, NTRK1
2neurotrophin bindingGO:00431219.5NTRK1, NTRK3
3GPI-linked ephrin receptor activityGO:00050049.3NTRK1, NTRK3

Sources for Anhidrosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet