Ankylosing Spondylitis malady

MedlinePlus: Ankylosing spondylitis is a type of arthritis of the spine. it causes swelling between your vertebrae, which are the disks that make up your spine, and in the joints between your spine and pelvis. ankylosing spondylitis is an immune disease. the disease is more common and more severe in men. it often runs in families. early symptoms include back pain and stiffness. these problems often start in late adolescence or early adulthood. over time, ankylosing spondylitis can fuse your vertebrae together, limiting movement. symptoms can worsen or improve or stop altogether. the disease has no cure, but medicines can relieve the pain, swelling and other symptoms. exercise can also help. nih: national institute of arthritis and musculoskeletal and skin disease²³

MalaCards: Ankylosing Spondylitis, also known as spondyloarthritis ankylopoietica, is related to arthritis and rheumatoid arthritis, and has symptoms including pain, stiffness in the spine and stiffness in the neck. An important gene associated with Ankylosing Spondylitis is TAP2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)), and among its related pathways are Immune System and Antigen processing and presentation. The drugs diclofenac and naproxen and the compounds ionomycin and ivig have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, skeletal muscle and colon, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology: A bone inflammation disease that results in inflammation in the joints of the spine and pelvis. the disease has symptom pain, has symptom stiffness in the spine, has symptom stiffness in the neck, has symptom stiffness in the hips, has symptom stiffness in the jaw and has symptom stiffness in the rib cage.⁶

Genetics Home Reference: Ankylosing spondylitis is a form of ongoing joint inflammation (chronic inflammatory arthritis) that primarily affects the spine. This condition is characterized by back pain and stiffness that typically appear in adolescence or early adulthood. Over time, back movement gradually becomes limited as the bones of the spine (vertebrae) fuse together. This progressive bony fusion is called ankylosis.¹⁷

Wikipedia: Ankylosing spondylitis (AS, from Greek ankylos, crooked; spondylos, vertebrae; -itis, inflammation),...⁴⁴ more...

Aliases & Descriptions:

ankylosing spondylitis 6 17 8 23 43 spondyloarthritis ankylopoietica 17 spondylarthritis ankylopoietica 17 spondylitis ankylopoietica 17 marie-struempell disease 17 marie-strumpell disease 6 spondylitis, ankylosing 17 spondylitis ankylosing 32

spondylarthropathies 43 bekhterev's disease 6 bekhterev syndrome 6 bechterew disease 17 spondylarthritis 43 spondylitis 43 as 17

Diseases related to ankylosing spondylitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 3673)

id	Related Disease	Score	Top Affiliating Genes
1	arthritis	37.5	SERPINA1, VIP, MMP3, IL17A, IL1A, IL1B
2	rheumatoid arthritis	37.4	CHI3L1, IL1R1, IL1R2, IL1RN, HLA-DRB1, TNFRSF1A
3	hepatitis	35.1	SERPINA1, GSR, GPT, HLA-A, HLA-DRB1, TNFRSF1A
4	psoriatic arthritis	34.7	IL10, IL1B, IL1RN, IL6, TNF, NOD2
5	reactive arthritis	34.3	BSG, CD79A, HSPD1, HP, HLA-B, CRP
6	colorectal cancer	34.2	VDR, GSTP1, TNF, CYP1A1, CYP2D6, TLR2
7	klebsiella	33.7	MPO, CD79A, CD40LG, INS, IL17A, IL1B
8	sepsis	33.4	CD14, IL10, TNF, LTA
9	asthma	32.9	MPO, CD14, IL12B, IL1B, IL4, CCL2
10	schizophrenia	32.8	CHI3L1, IL1B, IL1RN, IL2, IL4, CCR5
11	spondyloarthropathy	32.2	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
12	multiple sclerosis	31.9	MST1, CD14, MICA, IL1A, IL1B, IL1RN
13	hodgkin's lymphoma	31.7	BSG, JAK2, CD68, IL1RN, IL2, CCR4
14	parkinson's disease	31.6	CHKB, GSR, HSPA8, CAT, CYP1A1, CYP2D6
15	iritis	31.4	MRAP, CD79A, CD40LG, HLA-B
16	spondylarthropathy	31.3	MMP3, IL10, IL1A, IL1B, IL4, IL6
17	behcet's disease	31.3	KIR2DL1, KIR3DL1, LBR, MEFV, APOH, CCR5
18	anterior uveitis	31.2	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
19	immunodeficiency	31.1	PDCD1, KIR3DL1, VIP, CD79A, CD40LG, CD274
20	acute lymphoblastic leukemia	31.1	KIR3DL1, MPO, JAK2, GSTP1, IGH@, HLA-B
21	b-cell lymphomas	31.1	JAK2, CD14, GSTP1, CCL7, IGH@, ALPP
22	tuberculosis	31.0	VDR, IL10, IL12B, IL1B, IL1RN, IL4
23	chronic lymphocytic leukemia	30.9	JAK2, CD40LG, IL2, IL4, CCR5, IGH@
24	ankylosis	30.8	BMP2, ENPP1, ANKH, ERAP1, HLA-B, TNFRSF11B
25	spondylitis	30.8	ZNF365, PDCD1, PDCD1LG2, RELA, KIR2DS3, KIR2DS5
26	crohn's disease	30.7	BMP7, CHI3L1, MPO, IL10, IL12B, IL17A
27	familial mediterranean fever	30.6	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1, KIR2DL1
28	osteomalacia	30.6	GC, VDR, BGLAP, CD36, GSTP1, ENPP1
29	squamous cell carcinoma	30.6	RELA, GC, BSG, VEGFA, BMP2, MMP1
30	hepatitis c	30.5	SERPINA1, CD40LG, MMP1, GSR, IL10, IL12B
31	hepatitis b	30.5	PDCD1, CD274, IL10, IL12B, IL17A, CCR5
32	renal cell carcinoma	30.2	PDCD1, RELA, BSG, VEGFA, BMP7, USO1
33	non-hodgkin lymphoma	30.0	VDR, LBR, JAK2, CD14, IL12B, IL2
34	t-cell leukemia	30.0	RELA, LBR, IL1A, IL2, CCR4, IGH@
35	malaria	29.9	CD36, CD40LG, IL10, IL1A, IL4, IFNG
36	periodontitis	29.9	BSG, VDR, MPO, CD36, CD14, MMP1
37	abdominal aortic aneurysm	29.4	MMP1, MMP3, FBN1, CCL2, TNFRSF11B, TNFRSF1A
38	primary biliary cirrhosis	29.4	PDCD1, VDR, BGLAP, LBR, CD79A, CD40LG
39	atopic dermatitis	29.4	VIP, LBR, CD14, IL10, IL12B, IL17A
40	autonomic dysfunction	29.3	INS, IL6, APOA1, CRP, RPS27A, ADIPOQ
41	ulcerative colitis	29.3	SERPINA1, VIP, BGLAP, CHI3L1, CHKB, MPO
42	septic shock	29.1	VIP, CD14, IL10, IL12B, IL1A, IL1B
43	uveitis	29.1	KIR2DS3, KIR2DS5, KIR2DP1, KIR2DL1, KIR2DL3, KIR3DS1
44	autoimmune hepatitis	29.1	PDCD1, CD14, CD40LG, CD274, GPT, HSPD1
45	celiac disease	29.0	IL6, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, CTLA4
46	retinol binding protein	28.9	LEP, INS, APOA1, CCL2, HSPA5, HP
47	myelodysplastic syndrome	28.8	KIR3DL1, VDR, MPO, JAK2, IL1A, TNFSF10
48	autoimmune thyroiditis	28.7	CHKB, IL12B, IL4, IFNG, ICAM1, CALCA
49	periodic fever	28.7	SAA1, MEFV, IL1B, IL1R1, IL1RN, IFNG
50	burkitt's lymphoma	28.6	CD40LG, IL4, IGH@, ICAM1, HSPD1, TRADD

Symptoms: pain, stiffness in the spine, stiffness in the neck, stiffness in the hips, stiffness in the jaw, stiffness in the rib cage.⁶

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 diclofenac, diclofenac potassium, diclofenac sodium, ibuprofen, naproxen, naproxen sodium, piroxicam

Cell-based therapeutics:

MalaCards organs/tissues related to ankylosing spondylitis:

²²

MGI Mouse Phenotypes related to ankylosing spondylitis:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.2	PDCD1, PDCD1LG2, BMP4, KDM5A, MST1, MSX2
2	respiratory system phenotype	MP:0005388	10.7	CD14, IL12B, FBN1, ANKH, CCR4, ALPL
3	craniofacial phenotype	MP:0005382	10.5	BMP4, LBR, MSX2, FLNB, IL12B, IL17A
4	endocrine/exocrine gland phenotype	MP:0005379	10.1	KDM5A, MSX2, ATG16L1, CDKAL1, CD40LG, IL2
5	embryogenesis phenotype	MP:0005380	10.1	MSX2, ITGB7, FBN1, ALPL, ALPP, HSPA5
6	renal/urinary system phenotype	MP:0005367	9.3	PDCD1, BMP4, BMP7, INS, FBN1, HSPA5
7	integument phenotype	MP:0010771	9.1	RELA, LBR, MSX2, CD274, GSTP1, MEFV
8	immune system phenotype	MP:0005387	9.0	VWF, BSG, VDR, KDM5A, LBR, MST1
9	limbs/digits/tail phenotype	MP:0005371	8.9	RELA, VEGFA, VDR, BMP2, BMP4, BMP7
10	other phenotype	MP:0005395	8.8	JAK2, CD40LG, IL2, FBN1, ENPP1, ANKH
11	hearing/vestibular/ear phenotype	MP:0005377	8.6	VDR, BMP2, BMP4, BMP7, MSX2, IL22
12	growth/size phenotype	MP:0005378	8.0	RELA, BSG, VDR, BMP2, BMP4, BMP7
13	no phenotypic analysis	MP:0003012	8.0	PDCD1LG2, VEGFA, BMP4, LBR, CD79A, CD274
14	nervous system phenotype	MP:0003631	7.9	PDCD1, RELA, VWF, BMP2, BMP4, BMP7
15	liver/biliary system phenotype	MP:0005370	7.7	VEGFA, BMP4, MST1, CD36, INS, MEFV
16	mortality/aging	MP:0010768	6.8	PDCD1, PDCD1LG2, RELA, VWF, BSG, VEGFA
17	digestive/alimentary phenotype	MP:0005381	6.5	VWF, VEGFA, VDR, BMP2, BMP4, BMP7
18	reproductive system phenotype	MP:0005389	6.5	VIP, VEGFA, VDR, BMP2, BMP7, LEP
19	behavior/neurological phenotype	MP:0005386	6.5	VIP, BMP4, KDM5A, LEP, CHKB, LBR
20	skeleton phenotype	MP:0005390	6.4	RELA, GC, VEGFA, VDR, BMP2, BMP4
21	normal phenotype	MP:0002873	6.2	RELA, VIP, VEGFA, BMP2, BMP4, BMP7
22	adipose tissue phenotype	MP:0005375	5.8	LEP, LBR, CD36, CD14, INS, IL1R1
23	vision/eye phenotype	MP:0005391	5.7	PDCD1, RELA, VEGFA, BMP4, BMP7, LEP
24	muscle phenotype	MP:0005369	5.1	PDCD1, RELA, VEGFA, BMP4, LEP, CHKB
25	tumorigenesis	MP:0002006	5.0	PDCD1LG2, KDM5A, LEP, JAK2, GSTP1, IL10
26	cellular phenotype	MP:0005384	3.1	PDCD1, PDCD1LG2, RELA, VWF, VEGFA, VDR
27	homeostasis/metabolism phenotype	MP:0005376	2.6	PDCD1LG2, RELA, VWF, GCKR, GC, VIP
28	cardiovascular system phenotype	MP:0005385	2.6	PDCD1, RELA, VWF, VEGFA, VDR, BMP2

Articles related to ankylosing spondylitis:

(show top 50)    (show all 375)

id	Title	Authors	Year	Affiliating Genes
1	Correlation of HLA B27 subtypes with clinical feature s of ankylosing spondylitis. (22004234)	Chavan H.... Mankeshwar R.	2011	HLA-B
2	Contribution of TNF-I+-308 gene polymorphisms to susce ptibility to the development of uveitis in Korean patients with HLA-B27-positiv e ankylosing spondylitis. (21639826)	Park K.S.... Lee S.H.	2011	TNF
3	Different response to rituximab in tumor necrosis fac tor blocker-naive patients with active ankylosing spondylitis and in patients i n whom tumor necrosis factor blockers have failed: a twenty-four-week clinical trial. (20461780)	Song I.H.... Sieper J.	2010	TNF
4	No association of KIR3DL1 or KIR3DS1 or their alleles with ankylosing spondylitis. (19874556)	McCappin J.... Middleton D.	2010	KIR3DL1, KIR3DS1
5	ERAP1 Is Associated with Ankylosing Spondylitis in Ha n Chinese. (21078719)	Li C.... Gu J.	2010	ERAP1
6	Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients. (21041274)	Bang S.Y.... Inman R.D.	2010	ERAP1, IL1R2, ANTXR2
7	The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1- associated death domain (TRADD). (19854717)	Pointon J.J.... Wordsworth B.P.	2010	TNFRSF1A, TRADD
8	Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population. (19917163)	Pimentel-Santos F.M.... Branco J.C.	2009	ERAP1, IL23R
9	HLA-B27 and HLA-B51 determination in Tunisian healthy subjects and patients with suspected ankylosing spondylitis and BehAset's disea se. (19758200)	Sakly N.... Ghedira I.	2009	HLA-B
10	The immune response to autologous bacteroides in ankylosing spondylitis is characterized by reduced interleukin 10 production. (19228651)	Stebbings S.M.... Highton J.	2009	IL10, IL17A
11	HLA haplotype A33-B58-Cw10 may modulate radiographic development of bamboo spine in Taiwanese patients with primary ankylosing spondylitis. (19407364)	Lu M.C.... Lai N.S.	2009	HLA-DQA1, HLA-A, HLA-DRB1
12	Distribution of HLA-B27 and its alleles in patients with reactive arthritis and with ankylosing spondylitis in Tunisia. (19152094)	Siala M.... Makni H.	2009	HLA-B
13	Human leucocyte antigen-B27 subtypes in Korean patien ts with ankylosing spondylitis: higher B*2705 in the patient group. (20374314)	Park S.H.... Choe J.Y.	2009	HLA-B
14	Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondyl itis. (19731629)	Ziegler A.... Uchanska-Ziegler B.	2009	HLA-B
15	Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis. (18785308)	Maksymowych W.P.... Inman R.D.	2008	MMP3, CRP
16	Anti-nuclear antibodies, anti-DNA and C4 complement evolution in rheumatoid arthritis and ankylosing spondylitis treated with TNF-alpha blockers. (18578960)	Gonnet-Gracia C.... Schaeverbeke T.	2008	TNF
17	Clinical study of etanercept for treating ankylosing spondylitis (18753057)	Liang L.Q.... Yang X.Y.	2008	MMP3, TNF, CRP
18	Biologics in the early treatment of ankylosing spondylitis and related forms of spondyloarthritis (18500471)	Langer H.E.	2008	TNF
19	Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation. (18512784)	Smith J.A.... Colbert R.A.	2008	IFNG
20	Usefulness of human leucocyte antigen-B27 subtypes in predicting ankylosing spondylitis: Taiwan experience. (17908086)	Hou T.Y.... Lai J.H.	2007	HLA-B
21	Changes of clinical response and bone biochemical markers in patients with ankylosing spondylitis taking etanercept. (17610317)	Woo J.H.... Kim T.H.	2007	MMP3, CRP
22	Association of toll-like receptor 4 variants and ankylosing spondylitis: a case-control study. (17143969)	Snelgrove T.... Rahman P.	2007	TLR4
23	Interleukin 1 and nuclear factor-kappaB polymorphisms in ankylosing spondylitis in Canada and Korea. (16206345)	Kim T.H.... Inman R.D.	2005	NFKB1, IL1B, IL1A
24	Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis. (16277694)	Raffeiner B.... Schirmer M.	2005	TLR2, TLR4
25	Validation of the Italian versions of the Bath Ankylosing Spondylitis Functional Index (BASFI) and the Dougados Functional Index (DFI) in patients with ankylosing spondylitis (16258600)	Salaffi F.... Grassi W.	2005	CRP
26	Understanding the role of tumor necrosis factor inhib ition in ankylosing spondylitis. (15692960)	Davis J.C.	2005	TNF
27	Lack of linkage of IL1RN genotypes with ankylosing spondylitis susceptibility. (15457475)	Jin L.... Reveille J.D.	2004	IL1RN
28	Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis. (15517638)	Franck H.... Hofbauer L.C.	2004	TNFRSF11B, TNFSF11
29	Methotrexate for ankylosing spondylitis. (15266537)	Chen J.... Liu C.	2004	CRP
30	Down-regulation of the nonspecific and antigen-specific T cell cytokine response in ankylosing spondylitis during treatment with infliximab. (12632433)	Zou J.... Sieper J.	2003	TNF, IFNG, IL10
31	Vitamin D receptor initiation codon polymorphism, bone density and inflammatory activity of patients with ankylosing spondylitis. (14530911)	Obermayer-Pietsch B.M.... Leb G.	2003	VDR
32	Is fibrillin-1 the link between ankylosing spondylitis and Marfan's syndrome? (12180757)	Fietta P.... Manganelli P.	2002	FBN1
33	Increased osteoprotegerin and decreased pyridinoline levels in patients with ankylosing spondylitis: comment on the article by GratacA^s et al. (12483748)	Golmia R.P.... Scheinberg M.A.	2002	TNFRSF11B
34	Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. (11986408)	Gorman J.D.... Davis J.C.	2002	TNF, TNFRSF1B
35	Serum 25-hydroxyvitamin D and parathyroid hormone in patients with ankylosing spondylitis before and after a three-week rehabilitation treatment at high altitude during winter and spring. (11388078)	Falkenbach A.... Herold M.	2001	PTH
36	TNF-238A promoter polymorphism contributes to susceptibility to ankylosing spondylitis in HLA-B27 negative patients. (11409121)	Gonzalez S.... Lopez-Larrea C.	2001	TNF, HLA-DRB1, HLA-B
37	Impaired expression of IgA Fc receptors (CD89) by blood phagocytic cells in ankylosing spondylitis. (10685807)	Montenegro V.... Monteiro R.C.	2000	CD79A, FCAR
38	Biochemical bone turnover markers in patients with ankylosing spondylitis. (10791618)	Yilmaz N.... Ozaslan J.	2000	ALPP, CRP, BGLAP
39	Interethnic studies of TNF polymorphisms confirm the likely presence of a second MHC susceptibility locus in ankylosing spondylitis. (11196671)	Milicic A.... Brown M.A.	2000	TNF
40	Relative value of erythrocyte sedimentation rate and C-reactive protein in assessment of disease activity in ankylosing spondylitis. (10229432)	Spoorenberg A.... van der Linden S.	1999	CRP
41	Biochemical markers of bone remodeling and bone sialoprotein in ankylosing spondylitis. (10556657)	Acebes C.... Herrero-Beaumont G.	1999	CD36, IBSP
42	Enterobacterial antibodies in Chinese patients with rheumatoid arthritis and ankylosing spondylitis. (9536392)	Chou C.T.... Toivanen P.	1998	CD40LG, CD79A
43	Osteomalacia and osteoporosis in a woman with ankylosing spondylitis. (9157786)	Kohlmeier L.A.... Leboff M.S.	1996	CALCA
44	Coexisting IgA nephropathy and leukocytoclastic cutaneous vasculitis associated with ankylosing spondylitis: a case report. (7712401)	Hsu C.M.... Chang D.M.	1995	CD79A
45	Prevalence of antiphospholipid antibodies in patients with ankylosing spondylitis. (8991987)	Juanola X.... Roig-Escofet D.	1995	APOH
46	IgM, IgA and IgG class serum antibodies against Klebsiella pneumoniae and Escherichia coli lipopolysaccharides in patients with ankylosing spondylitis. (7981989)	MAoki-Ikola O.... Granfors K.	1994	CD40LG
47	Serum antibodies from patients with ankylosing spondylitis and Reiter's syndrome are reactive with HLA-B27 cells transfected with the Mycobacterium tuberculosis hsp60 gene. (7905462)	Kellner H.... Yu D.T.	1994	HSPD1
48	Antibodies to Klebsiella pneumoniae, Escherichia coli , and Proteus mirabilis in ankylosing spondylitis: effect of sulfasalazine trea tment. (7869314)	NissilAo M.... Granfors K.	1994	CD79A
49	Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis. (1352961)	Higgins C.M.... Craig R.K.	1992	HLA-B
50	Systemic and mucosal antibodies to Klebsiella in patients with ankylosing spondylitis and Crohn's disease. (1485810)	O'Mahony S.... Ferguson A.	1992	CD79A

Genes related to ankylosing spondylitis according to GeneCards:

(show top 50)    (show all 203)

id	Symbol	Description	Score	GeneCards Section Context
1	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.1	Publications, Summaries
2	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.1	Summaries, Publications
3	HLA-B	major histocompatibility complex, class I, B	11.1	Aliases & Descriptions, Publications
4	KIR2DP1	killer cell immunoglobulin-like receptor, two domains, pseudogene 1	11.0	Publications
5	IL1F10	interleukin 1 family, member 10 (theta)	11.0	Publications
6	IL37	interleukin 37	11.0	Publications
7	KIR3DS1	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	11.0	Publications
8	ERAP1	endoplasmic reticulum aminopeptidase 1	11.0	Publications
9	IL36A	interleukin 36, alpha	11.0	Publications
10	KIR2DL5A	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A	11.0	Publications
11	KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	11.0	Publications
12	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.0	Publications
13	IRGM	immunity-related GTPase family, M	11.0	Publications
14	IL36G	interleukin 36, gamma	11.0	Publications
15	NKX2-3	NK2 homeobox 3	11.0	Publications
16	MUC19	mucin 19, oligomeric	11.0	Publications
17	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	11.0	Publications
18	ORMDL3	ORM1-like 3 (S. cerevisiae)	11.0	Publications
19	HSPA2	heat shock 70kDa protein 2	11.0	Publications
20	KIR2DS2	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	11.0	Publications
21	IL36B	interleukin 36, beta	11.0	Publications
22	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.0	Publications
23	IL36RN	interleukin 36 receptor antagonist	11.0	Publications
24	KIR2DS5	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5	11.0	Publications
25	OMP	olfactory marker protein	11.0	Publications
26	ITLN1	intelectin 1 (galactofuranose binding)	11.0	Publications
27	ERAP2	endoplasmic reticulum aminopeptidase 2	11.0	Publications
28	CREG1	cellular repressor of E1A-stimulated genes 1	11.0
29	KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	11.0	Publications
30	MRAP	melanocortin 2 receptor accessory protein	11.0
31	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
32	ORAI1	ORAI calcium release-activated calcium modulator 1	11.0	Publications
33	FCRL5	Fc receptor-like 5	11.0	Publications
34	KIR3DL3	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	11.0	Publications
35	CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	11.0	Publications
36	MST1	macrophage stimulating 1 (hepatocyte growth factor-like)	11.0	Publications
37	FCRL3	Fc receptor-like 3	11.0	Publications
38	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
39	IL17D	interleukin 17D	11.0	Publications
40	TAPBP	TAP binding protein (tapasin)	11.0	Publications
41	IL18RAP	interleukin 18 receptor accessory protein	11.0	Publications
42	IL1R2	interleukin 1 receptor, type II	11.0	Publications
43	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	11.0	Publications
44	IL22	interleukin 22	11.0	Publications
45	IL23A	interleukin 23, alpha subunit p19	11.0	Publications
46	TREM1	triggering receptor expressed on myeloid cells 1	11.0	Publications
47	SOST	sclerostin	11.0	Publications
48	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	11.0	Publications
49	CD68	CD68 molecule	11.0	Publications
50	PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	11.0	Publications

Pathways related to ankylosing spondylitis according to GeneDecks:

(show top 50)    (show all 157)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	11.3	PDCD1, PDCD1LG2, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3
2	Antigen processing and presentation20	11.2	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
3	Natural killer cell mediated cytotoxicity20	10.9	KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4
4	Graft-versus-host disease20	10.7	KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5A, KIR2DL2
5	RAR-Gamma-RXR-Alpha Degradation36	10.3	BMP2, BMP4, BMP7, IL2, IL22, IL23A
6	PGC1Alpha Pathway36	10.1	BMP2, BMP4, BMP7, IL12B, IL1A, IL1B
7	Cellular Transformation by HTLV136	10.0	RELA, JAK2, IFNG, HSPA1A, HSPA1B, HSPA8
8	Molecular Mechanisms of Cancer36	10.0	BMP2, BMP4, BMP7, ITGB7, IL12B, IL1R1
9	Intestinal immune network for IgA production20	9.9	CD40LG, ITGB7, IL10, IL2, IL4, IL6
10	Akt Signaling36	9.9	BMP2, BMP4, BMP7, IL10, IL12B, IL2
11	Th17 Differentiation37	9.9	JAK2, IL12B, IL17A, IL1B, IL1R1, IL22
12	IL-6 Pathway36	9.9	BMP2, BMP4, BMP7, IL10, IL12B, IL22
13	Allograft rejection20	9.7	CD40LG, IL10, IL12B, IL2, IL4, IFNG
14	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	IL12B, IL17A, IL1B, IL22, IL23A, IL23R
15	TRAF Pathway36	9.7	IL12B, IL1A, IL1B, IL1R1, TRADD, TNF
16	Cytokine production by Th17 cells in CF41	9.6	RELA, JAK2, CD14, IL12B, IL17A, IL23A
17	Cytokine production by Th17 cells in CF (Mouse model)41	9.6	RELA, JAK2, CD14, IL12B, IL17A, IL23A
18	Endothelin-1 Signaling Pathway36	9.3	BMP2, BMP4, BMP7, IL10, IL12B, IL1A
19	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.2	VDR, BGLAP, IL1A, IL1B, IL6, IGF1
20	Influenza A20	9.2	RELA, JAK2, IL12B, IL1A, IL1B, IL6
21	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.2	VDR, BGLAP, IL1A, IL1B, IL6, IGF1
22	Measles20	9.2	RELA, JAK2, IL12B, IL1A, IL1B, IL2
23	PEDF Induced Signaling36	9.1	RELA, BMP2, BMP4, BMP7, IL10, IL12B
24	STAT3 Pathway36	9.1	BMP2, BMP4, BMP7, JAK2, IL10, IL12B
25	Glucocorticoid Receptor Signaling36	9.0	BMP2, BMP4, BMP7, IL10, IL12B, IL1A
26	Type I diabetes mellitus20	9.0	INS, IL12B, IL1A, IL1B, IL2, IFNG
27	Toxoplasmosis20	8.9	RELA, JAK2, CD40LG, IRGM, IL10, IL12B
28	NF-KappaB (p50-p65) Pathway36	8.9	RELA, BMP2, BMP4, BMP7, IL1A, IL1B
29	NF-KappaB Family Pathway36	8.9	RELA, BMP2, BMP4, BMP7, IL1A, IL1B
30	all-trans-Retinoic Acid Signaling in Brain36	8.9	BMP2, BMP4, BMP7, IL10, IL12B, IL1A
31	Rheumatoid arthritis20	8.8	VEGFA, MMP1, MMP3, IL17A, IL1A, IL1B
32	Tuberculosis20	8.8	RELA, VDR, JAK2, CD14, IL10, IL12B
33	SOCS Pathway36	8.8	BMP2, BMP4, BMP7, JAK2, INS, IL10
34	MAPK Family Pathway36	8.7	BMP2, BMP4, BMP7, IL10, IL12B, IL1A
35	Malaria20	8.7	CD36, CD40LG, IL10, IL1B, IL6, CCL2
36	MIF Regulation of Innate Immune Cells36	8.6	BMP2, BMP4, BMP7, CD14, IL10, IL12B
37	Tec Kinases Signaling36	8.6	BMP2, BMP4, BMP7, JAK2, ITGB7, IL10
38	ERK Signaling36	8.5	BMP2, BMP4, BMP7, ITGB7, IL10, IL12B
39	TGF-Beta Pathway36	8.5	BMP2, BMP4, BMP7, IL10, IL12B, IL1A
40	Immune response MIF-mediated glucocorticoid regulation10	8.5	RELA, MMP1, IL2, IL6, IFNG, ICAM1
41	Immune response_MIF-mediated glucocorticoid regulation41	8.5	RELA, MMP1, IL2, IL6, IFNG, ICAM1
42	MIF Mediated Glucocorticoid Regulation36	8.4	BMP2, BMP4, BMP7, CD14, IL10, IL12B
43	p38 Signaling36	8.4	BMP2, BMP4, BMP7, IL10, IL12B, IL1A
44	Chagas disease (American trypanosomiasis)20	8.4	RELA, IL10, IL12B, IL1B, IL2, IL6
45	PAK Pathway36	8.3	BMP2, BMP4, BMP7, IL10, IL12B, IL1A
46	Leishmaniasis20	8.3	RELA, JAK2, IL10, IL12B, IL1A, IL1B
47	Rho Family GTPases36	8.3	BMP2, BMP4, BMP7, ITGB7, IL10, IL12B
48	Antioxidant Action of Vitamin-C36	8.1	BMP2, BMP4, BMP7, JAK2, FLNB, IL10
49	JAK-STAT Pathway36	8.0	BMP2, BMP4, BMP7, JAK2, IL10, IL12B
50	Cytokine-cytokine receptor interaction20	7.7	VEGFA, BMP2, BMP7, LEP, CD40LG, IL10

Compounds related to ankylosing spondylitis according to GeneDecks:

(show top 50)    (show all 433)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.7	CD274, HSPA5, TNFRSF1A, NFKBIA
2	ivig32	10.4	VWF, CCR5, CRP, LTA, CSF1
3	hyaluronic acid32 18	11.2	CHI3L1, CD36, MMP1, MMP3, FBN1, GPT
4	budesonide32 42 9 9	13.2	BGLAP, CD36, NR3C1, LTF
5	sulfasalazine32 9 9	12.2	MPO, CD79A, CD40LG, MMP3, IL12B, IL1A
6	polyethylene glycol32	10.1	VIP, BMP2, CHKB, MPO, APOA1, ALPP
7	okt332	9.9	LBR, CD79A, CD40LG, IL10, IL2, IL6
8	latex32	9.8	VWF, CHKB, CD14, CD68, IL1RN, APOH
9	tgf beta132	9.8	BMP7, CD36, MMP1, MMP3, IL10, IL1RN
10	fmlp32	9.7	GC, MPO, CD14, IL1A, IL1B, IL1RN
11	zoledronic acid32	9.7	BMP2, BGLAP, CD36, IL2, IBSP, ALPP
12	progesterone32 42 9 18 9	13.7	BSG, BMP2, BMP4, BMP7, FBN1, HSPA1A
13	cysteine32	9.6	KIR2DS4, SERPINA1, VDR, BMP4, BGLAP, CHKB
14	n acetylcysteine32	9.6	VWF, JAK2, CD79A, MMP1, MMP3, IL1R1
15	corticosterone32 18	10.6	VIP, BGLAP, MPO, IL1A, IL1B, IL1R1
16	pamidronate32 9 9	11.6	BGLAP, CD36, MMP1, IL10, IL6, ALPP
17	estradiol32 9 18 9	12.5	GC, CHKB, SAA1, IL1R1, ESR1, TNFRSF11B
18	prostaglandin32	9.3	VIP, MMP1, MMP3, IL17A, IL1A, IL1B
19	polymyxin b32	9.2	CD14, IL10, IL1A, IL1B, IL1RN, IL4
20	ccl332	8.9	IL10, IL1A, IL1B, IL1R1, IL6, CCL7
21	adenylate32	8.9	VWF, GC, VIP, VDR, BMP4, CHKB
22	testosterone32 9 18 9	11.9	RELA, GC, VIP, VDR, BMP2, BGLAP
23	infliximab32 9 9	10.8	VEGFA, BGLAP, LBR, MMP1, MMP3, IL10
24	raloxifene32 9 9	10.8	VWF, VDR, BMP2, BGLAP, CHKB, CD36
25	prednisolone32 9 9	10.7	VWF, VIP, BGLAP, CHKB, MPO, CD79A
26	histamine32 18	9.7	VWF, VIP, BGLAP, LBR, MPO, CD79A
27	nitric oxide32 9 18 9	11.7	SERPINA1, BMP2, BMP4, CHI3L1, CHKB, MST1
28	etanercept32 9 9	10.6	LEP, MMP1, MMP3, IL10, IL17A, IL1B
29	rapamycin32 42	9.3	VEGFA, BMP2, BMP4, JAK2, INS, IL1R1
30	triptolide32	8.0	VEGFA, CD14, MMP3, IL1B, IL2, IL6
31	thalidomide32 42 9 9	11.0	VEGFA, CD36, CD40LG, IL10, IL1B, IL2
32	sb 20358032 42	8.9	BSG, VEGFA, VDR, BMP2, BMP4, BGLAP
33	methotrexate32 34 42 9 9	11.9	LEP, CHKB, CD79A, MMP1, MMP3, GSR
34	rosiglitazone32 9 18 9	10.8	LEP, JAK2, CD36, MMP1, INS, IL1R1
35	tacrolimus32 34 9 9	10.6	VDR, BMP2, CHKB, CD79A, CD36, INS
36	pioglitazone32 9 9	9.6	BSG, VEGFA, LEP, MMP1, INS, GSR
37	tamoxifen32 34 9 9	10.4	VEGFA, VDR, BGLAP, LEP, CHKB, IL2
38	ly29400232	7.3	VEGFA, LEP, IL10, IL17A, IL1B, IL4
39	herbimycin a32 42	8.3	JAK2, CD36, CD14, CD40LG, MMP1, IL1A
40	phosphatidylinositol32	7.2	BMP4, LEP, JAK2, CD14, INS, IL12B
41	paraffin32	7.2	RELA, VWF, SERPINA1, VEGFA, BGLAP, LEP
42	prostacyclin32	7.0	VWF, VIP, VEGFA, LEP, IL10, IL1A
43	hydrocortisone32 9 9	8.9	BGLAP, CD36, CD14, MMP1, INS, IL10
44	cisplatin32 34 9 9	9.5	VEGFA, BGLAP, LEP, LBR, MPO, JAK2
45	tyrosine32	6.4	PDCD1, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, KIR2DL5A
46	lactate32	6.4	VWF, VIP, BSG, BMP2, CHKB, MPO
47	vegf32	5.7	VWF, VIP, BSG, BMP2, BMP4, BMP7
48	serine32	5.4	RELA, VWF, GC, SERPINA1, VIP, BSG
49	actinomycin d32	4.1	VEGFA, VDR, BMP2, BMP4, JAK2, CD40LG
50	dexamethasone32 42 34 9 9	6.6	VWF, VIP, VEGFA, VDR, BMP2, BMP4

Cellular components related to ankylosing spondylitis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.5	TAPBP, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPB1
2	ER to Golgi transport vesicle membrane	GO:012507	10.4	HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C
3	membrane-bounded vesicle	GO:031988	10.3	SPP1, IBSP, BGLAP, BMP4, BMP2
4	integral to plasma membrane	GO:005887	10.3	TNF, HLA-DRB1, HLA-DRA, HLA-DQA1, HLA-C, HLA-B
5	membrane raft	GO:045121	10.1	TLR4, LRRK2, TNFRSF1B, TNFRSF1A, TNF, ITLN1
6	MHC class II protein complex	GO:042613	10.0	HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPB1
7	external side of plasma membrane	GO:009897	9.4	ICOSLG, HLA-DRB1, TNF, TNFRSF11A, CTLA4, TLR2
8	proteinaceous extracellular matrix	GO:005578	9.3	FBN1, TNFRSF11B, ACAN, TGFB1, HAPLN1, MMP3
9	cell surface	GO:009986	9.0	HSPA2, HSPA5, HSPA8, HSPD1, TNF, TNFRSF1A
10	plasma membrane	GO:005886	9.0	HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA
11	secretory granule	GO:030141	8.7	VEGFA, MPO, INS, IL1B, APOA1, HSPD1
12	extracellular region	GO:005576	5.9	MMP1, MMP3, INS, FCAR, IL1A, IL1B
13	extracellular space	GO:005615	5.6	ADM, ADIPOQ, GC, IL17A, IL17D, IL1A

Biological processes related to ankylosing spondylitis according to GeneDecks:

(show top 50)    (show all 102)

id	Name	GO ID	Score	Top Affiliating Genes
1	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	11.1	CD36, PSMD7, HLA-A, HLA-B, HLA-C, RPS27A
2	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO:019885	10.9	TAP2, TAP1, TAPBP, ERAP1, ERAP2
3	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	10.9	CD36, HLA-A, PSMD7, HLA-B, HLA-C, RPS27A
4	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	10.9	PSMD7, HLA-C, HLA-B, HLA-A, CD36, PSMB8
5	regulation of immune response	GO:050776	10.9	KIR2DL3, HLA-A, CD40LG, ICAM1, KIR3DL2, HLA-C
6	positive regulation of osteoclast differentiation	GO:045672	10.8	IL12B, IL17A, IL23A, TNF, TNFSF11, CSF1
7	T cell costimulation	GO:031295	10.7	HLA-DRB1, CTLA4, PDCD1, PDCD1LG2, CD274, ICOSLG
8	positive regulation of interleukin-10 production	GO:032733	10.6	IL23A, NOD2, HSPD1, IL4, CD40LG, IL12B
9	response to mechanical stimulus	GO:009612	10.6	TNF, SOST, CCL2, BGLAP, BMP4, PTGER4
10	positive regulation of interferon-gamma production	GO:032729	10.5	CD40LG, IL12B, IL1B, TLR4, LTA, TNF
11	monocyte chemotaxis	GO:002548	10.4	TNFSF11, IL6, CCL2, TNFRSF11A, CALCA, CCL7
12	humoral immune response	GO:006959	10.4	TREM1, TNF, LTA, LTF, CCL2, IFNG
13	immune response	GO:006955	10.4	PDCD1LG2, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B
14	positive regulation of interleukin-17 production	GO:032740	10.4	IL12B, IL2, IL23A, IL23R, TGFB1, NOD2
15	positive regulation of NF-kappaB import into nucleus	GO:042346	10.4	IL1B, IL23A, TNF, TLR2, IL12B, TLR4
16	positive regulation of interleukin-12 production	GO:032735	10.3	CD36, CD40LG, IL12B, IL23A, IL23R, IFNG
17	positive regulation of interleukin-6 production	GO:032755	10.2	TNF, TLR4, TLR2, NOD2, HSPD1, IL6
18	negative regulation of growth of symbiont in host	GO:044130	10.2	TLR2, IL10, IL12B, TNF, LTA, CD36
19	positive regulation of T cell proliferation	GO:042102	10.2	IFNG, IL4, IL23R, IL1B, IL12B, PDCD1LG2
20	positive regulation of tumor necrosis factor production	GO:032760	10.2	IFNG, TLR4, TLR2, NOD2, TNFRSF1A, IL23A
21	positive regulation of inflammatory response	GO:050729	10.1	TLR4, JAK2, IL12B, TLR2, PTGER4, TNFRSF1A
22	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.1	CD36, IL1A, IL1B, TRADD, TLR4, RPS27A
23	interferon-gamma-mediated signaling pathway	GO:060333	10.1	HLA-C, HLA-A, HLA-B, HLA-DPB1, HLA-DQA1, HLA-DQB1
24	defense response to Gram-negative bacterium	GO:050829	10.1	IL12B, IL23A, IL23R, IL6, TLR4, NOS2
25	positive regulation of activated T cell proliferation	GO:042104	10.0	IL12B, IGF1, IL4, IL23R, IL23A, IL2
26	negative regulation of inflammatory response	GO:050728	10.0	ADIPOQ, TNFRSF1B, APOA1, IL2, MEFV, SAA1
27	lipopolysaccharide-mediated signaling pathway	GO:031663	9.9	CCL2, NFKBIA, TNF, TGFB1, TLR4, TLR2
28	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.8	IL23R, IL2, IL12B, JAK2, IGF1, IL4
29	positive regulation of cytokine secretion	GO:050715	9.8	TNFSF15, SAA1, CD14, INS, IL10, IL1A
30	acute-phase response	GO:006953	9.8	SERPINA1, SAA1, IL1RN, IL22, IL6, INS
31	elevation of cytosolic calcium ion concentration	GO:007204	9.7	EDN1, IL1B, IL2, CCR6, CCR4, CALCA
32	response to lipopolysaccharide	GO:032496	9.7	EDN1, TLR4, TNFRSF1A, IL1A, IL23R, TNFRSF11A
33	skeletal system development	GO:001501	9.6	TNFRSF11B, VDR, ALPL, IGF1, ANKH, FBN1
34	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.6	JAK2, IL10, IL1B, IL4, IL6, ESR1
35	cellular response to interleukin-1	GO:071347	9.4	NFKB1, ICAM1, CCL2, IL17A, CHI3L1, RELA
36	response to glucocorticoid stimulus	GO:051384	9.4	IL1RN, IL1B, IL10, BGLAP, CCL2, ALPL
37	cellular response to lipopolysaccharide	GO:071222	9.4	ICAM1, TNFRSF1B, CD14, NOS2, TLR4, IFNG
38	cytokine-mediated signaling pathway	GO:019221	9.2	IL1B, IL6, CCL2, IFNG, ICAM1, HLA-A
39	inflammatory response	GO:006954	9.2	CCR5, CCR4, CCL2, CCL7, IL6, IL36A
40	cell-cell signaling	GO:007267	9.0	CCL27, ADM, PTH, EDN1, INS, TNFSF10
41	anti-apoptosis	GO:006916	8.7	IL1B, IL10, NFKBIA, NFKB1, NR3C1, TNF
42	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	TNF, TNFRSF11A, TNFSF11, NOD2, RPS27A, NFKB1
43	platelet degranulation	GO:002576	8.6	HSPA5, APOA1, CD36, IGF1, TGFB1, SOD1
44	response to drug	GO:042493	8.5	IL1RN, TNF, ICAM1, TGIF1, IFNG, CCL2
45	platelet activation	GO:030168	8.5	CD40LG, VWF, SERPINA1, VEGFA, TGFB1, SOD1
46	negative regulation of cell proliferation	GO:008285	8.4	ADM, BMP2, VDR, SOD2, BMP4, TGIF1
47	response to hypoxia	GO:001666	8.3	BMP2, CRP, LTA, EDN1, TLR4, TGFB1
48	negative regulation of apoptotic process	GO:043066	7.9	IL1RN, INS, MSX2, LEP, BMP4, VEGFA
49	positive regulation of nitric oxide biosynthetic process	GO:045429	7.9	ESR1, PTGS2, EDN1, IL1B, TLR2, IFNG
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.6	VDR, VEGFA, RELA, TLR4, BMP2, IL2

Molecular functions related to ankylosing spondylitis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-1 receptor antagonist activity	GO:005152	10.9	IL37, IL36RN, IL36G, IL1RN, IL1F10
2	interleukin-1 receptor binding	GO:005149	10.7	IL37, IL36B, IL36A, IL1RN, IL1B, IL1A
3	tumor necrosis factor receptor binding	GO:005164	10.7	LTA, TNFSF15, TNFSF11, TNFSF10, TNF, ERAP1
4	transmembrane signaling receptor activity	GO:004888	10.4	ICAM1, TNFRSF11A, TLR2, TLR4, IL1R1, IL18RAP
5	MHC class II receptor activity	GO:032395	10.3	KRT17, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
6	receptor activity	GO:004872	10.0	TLR4, TLR2, TNFRSF11B, TNFRSF11A, TREM1, ICAM1
7	protease binding	GO:002020	9.6	TNF, HSPA1B, IL1R1, INS, SERPINA1, TNFRSF1A
8	receptor binding	GO:005102	9.3	HLA-B, TNFSF10, TNFSF15, NOS2, LTA, ADM
9	cytokine activity	GO:005125	8.6	ADIPOQ, IL36RN, IL37, IL4, IL6, IFNG
10	hormone activity	GO:005179	7.8	ADIPOQ, ADM, PRL, EDN1, PTH, CALCA
11	growth factor activity	GO:008083	7.8	IL4, IL6, IGF1, TGFB1, CSF1, CSF3
12	protein homodimerization activity	GO:042803	7.2	CRP, NOS2, NFKB1, LRRK2, TGFB1, TAP1
13	protein binding	GO:005515	5.0	PTPN2, SRF, CTLA4, NR3C1, CRP, NOD2