AS
MCID: ANK002
MIFTS: 75

Ankylosing Spondylitis (AS) malady

Summaries for Ankylosing Spondylitis

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 21Genetics Home Reference, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Ankylosing spondylitis is a type of arthritis of the spine. it causes swelling between the vertebrae and in the joints between the spine and pelvis. this autoimmune disease is more common and more severe in men than in women. it is likely caused by a combination of genetic and environmental factors, most of which have not yet been identified. researchers have found variations in several genes that influence the risk of developing this disorder. these genes include hla-b, erap1, il1a, and il23r. early symptoms of ankylosing spondylitis include back pain and stiffness. these problems often start in late adolescence or early adulthood. over time, ankylosing spondylitis can fuse the vertebrae together, limiting movement. symptoms can worsen, improve, or stop altogether. the disease has no cure, but medicines can relieve the pain, swelling and other symptoms. exercise can also help. last updated: 11/25/2009

MalaCards: Ankylosing Spondylitis, also known as spondyloarthritis ankylopoietica, is related to arthritis and rheumatoid arthritis, and has symptoms including stiffness in the spine, stiffness in the neck and stiffness in the hips. An important gene associated with Ankylosing Spondylitis is TAP1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)), and among its related pathways are Allograft rejection and Immune response Fc epsilon RI pathway. The drugs diclofenac and ibuprofen and the compound rofecoxib have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and t cells.

Disease Ontology:8 A bone inflammation disease that results in inflammation in the joints of the spine and pelvis. the disease has symptom pain, has symptom stiffness in the spine, has symptom stiffness in the neck, has symptom stiffness in the hips, has symptom stiffness in the jaw and has symptom stiffness in the rib cage.

MedlinePlus:33 Ankylosing spondylitis is a type of arthritis of the spine. it causes swelling between your vertebrae, which are the disks that make up your spine, and in the joints between your spine and pelvis. ankylosing spondylitis is an immune disease. the disease is more common and more severe in men. it often runs in families. early symptoms include back pain and stiffness. these problems often start in late adolescence or early adulthood. over time, ankylosing spondylitis can fuse your vertebrae together, limiting movement. symptoms can worsen or improve or stop altogether. the disease has no cure, but medicines can relieve the pain, swelling and other symptoms. exercise can also help. nih: national institute of arthritis and musculoskeletal and skin disease

Genetics Home Reference:21 Ankylosing spondylitis is a form of ongoing joint inflammation (chronic inflammatory arthritis) that primarily affects the spine. This condition is characterized by back pain and stiffness that typically appear in adolescence or early adulthood. Over time, back movement gradually becomes limited as the bones of the spine (vertebrae) fuse together. This progressive bony fusion is called ankylosis.

Wikipedia:63 Ankylosing spondylitis (AS, from Greek ankylos, fused; spondylos, vertebra; -itis, inflammation),... more...

Aliases & Classifications for Ankylosing Spondylitis

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 44Novoseek, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:



Aliases & Descriptions:

ankylosing spondylitis 8 42 22 21 10 33 30 60
spondyloarthritis ankylopoietica 21
spondylarthritis ankylopoietica 21
ankylosing spondyloarthritis 42
spondylitis ankylopoietica 21
marie-struempell disease 21
spondylitis, ankylosing 21
marie-strumpell disease 8
spondylitis ankylosing 44
spondylarthropathies 60
bekhterev's disease 8
bekhterev syndrome 8
bechterew disease 21
as 21


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Disease Ontology8 DOID:7147
ICD9CM27 720.0
MeSH34 D013167
SNOMED-CT56 9631008, 156619005
NCIt39 C84564
ICD1025 M45

Related Diseases for Ankylosing Spondylitis

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17GeneCards, 18GeneDecks
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Diseases related to Ankylosing Spondylitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 5205)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.6PSMB9, HLA-B, CRP, TAP2, MMP3
2rheumatoid arthritis31.4CRP, IL23R, TAP2, MMP3, KIR3DL1
3uveitis31.2HLA-B
4psoriatic arthritis31.2CRP
5hepatitis31.2HLA-B
6lung cancer31.1PSMB9, TAP1, TAP2, MMP3
7hypertension31.1CRP
8melanoma31.0PSMB9, HLA-B, TAP1, TAP2, KIR3DL1
9reactive arthritis31.0HLA-B, CRP, TAP2
10hepatocellular carcinoma30.9KIR3DL1, TAP2, TAP1, PSMB9
11ovarian cancer30.9TAP2
12crohn's disease30.9IL23R, CRP
13diabetes mellitus30.8MMP3, TAP1, CRP, HLA-B
14psoriasis30.8ERAP1, KIR3DL1, KIR2DS1, TAP2, TAP1, IL23R
15hepatitis c30.8KIR3DL1, TAP2
16inflammatory bowel disease30.8MMP3, IL23R, CRP, HLA-B
17tuberculosis30.7CRP
18influenza30.6PSMB9, HLA-B, TAP1, TAP2, KIR2DL2
19cervical cancer30.6TAP2, TAP1
20familial mediterranean fever30.6CRP
21hepatitis b30.6KIR3DL1, MMP3, HLA-B
22ulcerative colitis30.5HLA-B, CRP, IL23R, MMP3
23systemic lupus erythematosus30.5CRP, TAP1, TAP2, MMP3
24sarcoidosis30.5TAP2, TAP1
25arthropathy30.5CRP, MMP3
26graves' disease30.4TAP2, TAP1, HLA-B, PSMB9
27acquired immunodeficiency syndrome30.4KIR3DL1, KIR2DL2, HLA-B
28endometriosis30.4KIR3DL1, MMP3
29kawasaki disease30.4MMP3, CRP
30leukemia30.3HLA-B, TAP1, TAP2, KIR3DL1
31multiple sclerosis30.3TAP2, TAP1, HLA-B
32myeloid leukemia30.3KIR3DL1
33burkitt's lymphoma30.3HLA-B, TAP2, MMP3, KIR3DL2, KIR3DL1
34vaccinia30.2HLA-B
35behcet's disease30.1HLA-B, CRP, KIR3DL1
36kidney cancer30.0TAP2, TAP1, HLA-B, PSMB9
37sjogren's syndrome30.0TAP2, TAP1
38bronchiectasis29.7TAP2
39viral infectious disease29.4HLA-B, TAP1, TAP2, MMP3, KIR3DL1
40nasopharynx carcinoma29.1MMP3, TAP1, HLA-B, PSMB9
41spondylitis11.6
42cauda equina syndrome10.9
43prostatitis10.8
44pancreatitis10.8
45adenocarcinoma10.8
46prostate cancer10.8
47hyperostosis10.7
48diffuse idiopathic skeletal hyperostosis10.7
49colorectal cancer10.7
50cerebritis10.7

Graphical network of the top 20 diseases related to Ankylosing Spondylitis:



Diseases related to ankylosing spondylitis

Clinical Features for Ankylosing Spondylitis

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8Disease Ontology
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Symptoms:

8
  • stiffness in the spine
  • stiffness in the neck
  • stiffness in the hips
  • stiffness in the jaw
  • stiffness in the rib cage
  • pain

Drugs & Therapeutics for Ankylosing Spondylitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ankylosing Spondylitis

Drug clinical trials:

Search ClinicalTrials for Ankylosing Spondylitis

Search NIH Clinical Center for Ankylosing Spondylitis

Search CenterWatch for Ankylosing Spondylitis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ankylosing Spondylitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ankylosing Spondylitis:
Umbilical cord-derived mesenchymal stem cells to treat ankylosing spondylitis
Embryonic/Adult Cultured Cells Related to Ankylosing Spondylitis:
Umbilical cord-derived mesenchymal stem cells (family)
Placenta-derived mesenchymal stem cells (family)

Genetic Tests for Ankylosing Spondylitis

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22GTR
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Genetic tests related to Ankylosing Spondylitis:

id Genetic test Affiliating Genes
1 Ankylosing Spondylitis22

Anatomical Context for Ankylosing Spondylitis

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Ankylosing Spondylitis:

32
Bone, Skin, T cells, Endothelial, Testes, Myeloid, Eye, Heart, Whole blood, Thyroid, Pituitary, Monocytes, Liver, Colon, Bone marrow, Lung, Brain, Breast, B cells, Nk cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ankylosing Spondylitis:
id TissueAnatomical CompartmentCell Relevance
1 PlacentaChorionic VillusChorionic Mesenchymal Stromal Cells Potential therapeutic candidate
2 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
3 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Ankylosing Spondylitis or affiliated genes

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Publications for Ankylosing Spondylitis

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50PubMed
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Articles related to Ankylosing Spondylitis:

(show top 50)    (show all 1232)
idTitleAuthorsYear
1
Modifiable cardiovascular risk factors in patients with ankylosing spondylitis. (24135890)
2014
2
Safe Re-administration of Tumor Necrosis Factor-alpha (TNFI+) Inhibitors in Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Who Developed Active Tuberculosis on Previous Anti-TNFI+ Therapy. (24431903)
2014
3
Association between ED in ankylosing spondylitis: a population-based study. (23552581)
2013
4
Correlation between insulin resistance and serum ghrelin in non-diabetic ankylosing spondylitis patients undergoing anti-TNF-I+ therapy. (23981480)
2013
5
Aspects of validity of the self-administered comorbidity questionnaire in patients with ankylosing spondylitis. (24249034)
2013
6
Fatigue and correlation with disease-specific variables, spinal mobility measures, and health-related quality of life in ankylosing spondylitis. (23224065)
2013
7
Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene polymorphism and plasma homocysteine levels. (23247802)
2013
8
Concurrent rheumatoid arthritis and ankylosing spondylitis in one patient: the importance of new classification criteria. (23588521)
2013
9
Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis. (23054009)
2013
10
A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis. (23928854)
2013
11
Infliximab dose reduction sustains the clinical treatment effect in active HLAB27 positive ankylosing spondylitis: a two-year pilot study. (24089587)
2013
12
Supervised training and home-based rehabilitation in patients with stabilized ankylosing spondylitis on TNF inhibitor treatment: a controlled clinical trial with a 12-month follow-up. (24285801)
2013
13
Consensus of Chinese orthopaedic experts on diagnosis and treatment of ankylosing spondylitis. (23420739)
2013
14
Precise Bending Rod Technique a Novel Method for Precise Correction of Ankylosing Spondylitis Kyphosis. (23429324)
2013
15
Which spinal lesions are associated with new bone formation in patients with ankylosing spondylitis treated with anti-TNF agents? A long-term observational study using MRI and conventional radiography. (23852807)
2013
16
Comparison of three enthesitis indices in a multicentre, randomized, placebo-controlled trial of golimumab in ankylosing spondylitis (GO-RAISE). (23024015)
2013
17
Serum prolidase activity in ankylosing spondylitis and rheumatoid arthritis. (23966806)
2013
18
IL-8 but not other biomarkers of endothelial damage is associated with disease activity in patients with ankylosing spondylitis without treatment with anti-TNF agents. (23297014)
2013
19
Fatigue in ankylosing spondylitis: causes, consequences and self-management. (22825963)
2013
20
High bone turnover assessed by 18F-fluoride PET/CT in the spine and sacroiliac joints of patients with ankylosing spondylitis: comparison with inflammatory lesions detected by whole body MRI. (22788874)
2012
21
ANKH and renal stone formation in ankylosing spondylitis. (22859534)
2012
22
Elevated liver enzymes in patients with ankylosing spondylitis treated with etanercept. (22941219)
2012
23
Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis. (23025387)
2012
24
Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis. (22213179)
2012
25
Hypoparathyroidism mimicking ankylosing spondylitis and myopathy: a case report. (21876989)
2011
26
Reproducibility of the Bath Ankylosing Spondylitis Indices of disease activity (BASDAI), functional status (BASFI) and overall well-being (BAS-G) in anti-tumour necrosis factor-treated spondyloarthropathy patients. (20306214)
2010
27
More night than day--circadian rhythms in polymyalgia rheumatica and ankylosing spondylitis. (20360185)
2010
28
Expressions of CD147 in peripheral monocytes and T lymphocytes of patients with ankylosing spondylitis]. (21211394)
2010
29
ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis. (19060001)
2009
30
Central nervous system Aspergillus fumigatus presenting as cranial nerve palsy in a patient with ankylosing spondylitis on anti-TNF therapy. (18381385)
2008
31
No differences of carotid intima-media thickness between young patients with ankylosing spondylitis and healthy controls. (18487068)
2008
32
Body composition, insulin, and leptin levels in patients with ankylosing spondylitis. (17260105)
2007
33
Bilateral fibrous ankylosis of temporomandibular joint associated with ankylosing spondylitis: a case report. (16626998)
2006
34
Radiographic progression in patients with ankylosing spondylitis after 2 years of treatment with the tumour necrosis factor alpha antibody infliximab. (15778240)
2005
35
Pathogenesis of ankylosing spondylitis and reactive arthritis. (15956835)
2005
36
Interleukin 1 and nuclear factor-kappaB polymorphisms in ankylosing spondylitis in Canada and Korea. (16206345)
2005
37
Laryngocele in association with ankylosing spondylitis. (16416373)
2005
38
Efficacy of anakinra in active ankylosing spondylitis: a clinical and magnetic resonance imaging study. (15066864)
2004
39
Prolactin and growth hormone responses to hypoglycemia in patients with rheumatoid arthritis and ankylosing spondylitis. (15570644)
2004
40
Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumatoid arthritis. (12730543)
2003
41
Decrease in serum nucleotide pyrophosphatase activity in ankylosing spondylitis. (12509614)
2003
42
Recommendations for starting anti TNF-alpha in patients with ankylosing spondylitis]. (14872220)
2003
43
Cellular immune response to Klebsiella pneumoniae antigens in patients with HLA-B27+ ankylosing spondylitis. (10852270)
2000
44
Coexisting IgA nephropathy and leukocytoclastic cutaneous vasculitis associated with ankylosing spondylitis: a case report. (7712401)
1995
45
Epidemiologic, clinical, and therapeutic aspects of reactive arthritis and ankylosing spondylitis. (7547104)
1995
46
Serum cytokines (IL-6, TNF-alpha, IL-1 beta and IFN-gamma) in ankylosing spondylitis: a close correlation between serum IL-6 and disease activity and severity. (7921752)
1994
47
Serum osteocalcin and vitamin D metabolites in patients with ankylosing spondylitis. (8323382)
1993
48
Differences in HLA-B27 positive and negative patients with ankylosing spondylitis: study of clinical disease activity and concentrations of serum IgA, C reactive protein, and haptoglobin. (2015008)
1991
49
The coexistence of ochronosis and ankylosing spondylitis. (1795348)
1991
50
Atlantoaxial subluxation in juvenile ankylosing spondylitis. (690785)
1978

Genetic Variations for Ankylosing Spondylitis

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Expression for genes affiliated with Ankylosing Spondylitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ankylosing Spondylitis

Search GEO for disease gene expression data for Ankylosing Spondylitis.

Pathways for genes affiliated with Ankylosing Spondylitis

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29KEGG, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Ankylosing Spondylitis

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank
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Compounds related to Ankylosing Spondylitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rofecoxib44 49 28 1113.6MMP3, CRP

GO Terms for genes affiliated with Ankylosing Spondylitis

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16Gene Ontology
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Cellular components related to Ankylosing Spondylitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.5KIR2DS5, HLA-B, CRP, TAP1, TAP2, KIR3DL2
2integral to plasma membraneGO:00588710.7HLA-B, KIR3DL2, KIR2DS3, KIR3DS1, KIR2DL4, KIR3DL1
3TAP complexGO:04282510.6TAP2, TAP1

Biological processes related to Ankylosing Spondylitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:05077611.3KIR3DL1, HLA-B, KIR3DL2, KIR2DL2, KIR2DS2, KIR2DL4
2immune responseGO:00695511.1HLA-B, KIR2DS2, KIR3DS1, KIR2DS1, KIR3DL1, KIR2DS5
3antigen processing and presentation of peptide antigen via MHC class IGO:00247411.1PSMB9, HLA-B, TAP1, TAP2, ERAP1
4positive regulation of T cell mediated cytotoxicityGO:00191611.0TAP2, TAP1, IL23R, HLA-B
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00247910.9PSMB9, HLA-B, TAP1, TAP2
6antigen processing and presentation of endogenous peptide antigen via MHC class IGO:01988510.9ERAP1, TAP2, TAP1
7antigen processing and presentation of exogenous peptide antigen via MHC class IGO:04259010.9TAP2, TAP1, HLA-B, PSMB9
8innate immune responseGO:04508710.9KIR2DS5, KIR2DS1, KIR3DS1, KIR2DS2, HLA-B
9cytosol to ER transportGO:04696710.7TAP1, TAP2
10intracellular transport of viral proteins in host cellGO:01906010.6TAP2, TAP1
11peptide transportGO:01583310.5TAP2, TAP1
12cellular defense responseGO:00696810.4KIR3DL2, KIR2DS3, KIR2DL4

Molecular functions related to Ankylosing Spondylitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:04260510.9TAP2, TAP1, HLA-B
2tapasin bindingGO:04698010.8TAP1, TAP2
3peptide transporter activityGO:01519710.8TAP1, TAP2
4transmembrane signaling receptor activityGO:00488810.7KIR2DS1, KIR2DL4, KIR2DS2
5TAP2 bindingGO:04697910.7TAP1, TAP2
6TAP1 bindingGO:04697810.6TAP1, TAP2
7oligopeptide-transporting ATPase activityGO:01542110.5TAP1, TAP2
8MHC class I protein bindingGO:04228810.3TAP2, TAP1

Products for genes affiliated with Ankylosing Spondylitis

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Sources for Ankylosing Spondylitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet