Ankylosis malady

Disease Ontology: Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. the rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.⁶

MalaCards: Ankylosis is related to arthropathy and ankylosing spondylitis. An important gene associated with Ankylosis is ANKH (ankylosis, progressive homolog (mouse)), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Human Embryonic Stem Cell Pluripotency. The compounds methylmethacrylate and alizarin have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and craniofacial.

Wikipedia: Ankylosis or anchylosis (from Greek ἀγκύλος, bent, crooked) is a stiffness of a joint due to...⁴⁴ more...

Aliases & Descriptions:

ankylosis 6 8 43

Diseases related to ankylosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 197)

id	Related Disease	Score	Top Affiliating Genes
1	arthropathy	33.0	BMP2, ANKH, HLA-B, TNFRSF11B
2	ankylosing spondylitis	27.5	ANKH, HLA-B, TNFRSF11B, TNFRSF1A
3	otosclerosis	26.1	BMP2, TNFRSF11B, PTH1R, NOG, NOTCH1, TGFB1
4	spondylitis	23.6	BMP2, ENPP1, ANKH, ERAP1, HLA-B, TNFRSF11B
5	periodontitis	22.0	BMP2, FGFR2, HLA-B, TNFRSF11B, TNFRSF1A, SP7
6	rheumatoid arthritis	21.2	SETD2, BMP2, FGFR1, FGFR2, ENPP1, HLA-B
7	cushing's symphalangism	13.6	NOG, GDF5
8	synostoses syndrome	13.5	NOG, GDF5
9	hypophosphatasia	13.4	ENPP1, ANKH, DSPP
10	brachydactyly type a2	13.4	BMP2, GDF5
11	dentin dysplasia, type ii	13.4	SPP1, DSPP
12	jackson-weiss syndrome	13.3	FGFR1, FGFR2
13	fgfr-related craniosynostosis syndromes	13.3	FGFR1, FGFR2
14	osteoglophonic dysplasia	13.3	FGFR1, FGFR2
15	tooth agenesis	13.3	FGFR1, DLX2, DSPP
16	muenke syndrome	13.3	FGFR1, FGFR2
17	plagiocephaly	13.2	FGFR1, FGFR2
18	dentinogenesis imperfecta	13.2	SP7, SPP1, DSPP
19	pseudogout	13.2	ENPP1, ANKH
20	tympanosclerosis	13.2	BMP2, SPP1
21	osteochondroma	13.2	BMP2, FGFR1, ACVR1
22	infectious mononucleosis	13.2	FGFR1, FGFR2, SP7
23	fibrodysplasia ossificans progressiva	13.2	BMP2, FGFR1OP, NOG, ACVR1
24	osteogenesis imperfecta	13.2	BMP2, PTH1R, SP7, DSPP
25	dysostosis	13.1	FGFR2, NOTCH1, DSPP
26	progressive osseous heteroplasia	13.1	BMP2, ENPP1, NOG, ACVR1
27	chst3-related skeletal dysplasia	13.1	FGFR1, FGFR2, PTH1R
28	achondroplasia	13.1	FGFR1, FGFR2, PTH1R
29	osteosclerosis	13.1	BMP2, TNFRSF11B, SP7
30	calcinosis	13.1	ENPP1, ANKH, SPP1, DSPP
31	hypophosphatemia	13.0	ENPP1, ANKH, PTH1R, DSPP, SLC20A2
32	craniosynostosis, syndromic	13.0	FGFR1, FGFR2, ENPP1, ANKH
33	hypodontia	13.0	FGFR2, DSPP, TGFB1
34	dwarfism	12.9	FGFR1, FGFR2, PTH1R, GDF5
35	syndactyly	12.9	FGFR1, FGFR2, DLX2, NOG, GDF5
36	chondrodysplasia	12.9	FGFR1, FGFR2, PTH1R, GDF5
37	aortic valve stenosis	12.9	BMP2, TNFRSF11B, SPP1
38	adenoameloblastoma	12.9	TNFRSF11B, TNFRSF1A, DSPP
39	synostosis	12.8	BMP2, FGFR1, FGFR2, NOG, GDF5
40	ossification of posterior longitudinal ligament of spine	12.7	BMP2, ENPP1, PTH1R, TGFB1
41	endolymphatic sac tumor	12.7	SETD2, HIF1A
42	hyperphosphatemia	12.7	BMP2, TNFRSF11B, SPP1, SLC20A2
43	root resorption	12.6	BMP2, TNFRSF11B, HEBP1, DSPP, GDF5, GDF7
44	secondary syphilis	12.6	BMP2, TNFRSF11B, PTH1R, SPP1
45	craniosynostosis	12.6	BMP2, FGFR1, FGFR2, ENPP1, ANKH, NOG
46	hyperostosis	12.6	TNFRSF11B, SPP1, TGFB1
47	arterial calcification	12.6	BMP2, ENPP1, TNFRSF11B, SPP1
48	hepatocellular cancer	12.5	FGFR1, SPP1, TGFB1
49	pleomorphic adenoma	12.5	BMP2, FGFR1, FGFR2, SPP1, GDF5
50	uremia	12.5	ENPP1, TNFRSF11B, PTH1R, SPP1

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to ankylosis:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.8	NOG, SP7, DLX2, PTH1R, ANKH
2	craniofacial phenotype	MP:0005382	8.8	DSPP, ACVR1, NOTCH1, NOG, DLX2, PTH1R
3	integument phenotype	MP:0010771	8.6	FGFR1, FGFR2, TNFRSF1A, NOG, NOTCH1
4	reproductive system phenotype	MP:0005389	8.3	GDF7, GDF5, TGFB1, NOG, SPP1, TNFRSF1A
5	limbs/digits/tail phenotype	MP:0005371	8.2	GDF5, NOG, SP7, TNFRSF1A, TNFRSF11B, ANKH
6	embryogenesis phenotype	MP:0005380	8.0	GDF7, NOTCH1, NOG, PTH1R, TNFRSF1A, FGFR2
7	renal/urinary system phenotype	MP:0005367	7.9	HIF1A, NOTCH1, NOG, ERAP1, FGFR2, FGFR1
8	hearing/vestibular/ear phenotype	MP:0005377	7.8	ACVR1, NOTCH1, NOG, DLX2, TNFRSF11B, ANKH
9	mortality/aging	MP:0010768	7.5	SP7, NOG, ACVR1, GDF5, GDF7, DLX2
10	muscle phenotype	MP:0005369	6.6	NOG, NOTCH1, HIF1A, TGFB1, SPP1, DLX2
11	digestive/alimentary phenotype	MP:0005381	6.5	TGFB1, HIF1A, ACVR1, NOTCH1, NOG, DLX2
12	skeleton phenotype	MP:0005390	6.1	BMP2, GDF5, HIF1A, NOTCH1, NOG, SPP1
13	homeostasis/metabolism phenotype	MP:0005376	5.7	SP7, SPP1, NOG, NOTCH1, HIF1A, TGFB1
14	cellular phenotype	MP:0005384	5.6	SPP1, NOG, NOTCH1, ACVR1, HIF1A, TGFB1
15	nervous system phenotype	MP:0003631	5.6	NOG, NOTCH1, ACVR1, HIF1A, TGFB1, GDF7
16	cardiovascular system phenotype	MP:0005385	5.5	SPP1, NOG, NOTCH1, ACVR1, HIF1A, TGFB1
17	growth/size phenotype	MP:0005378	5.0	SPP1, NOG, NOTCH1, ACVR1, HIF1A, TGFB1

Articles related to ankylosis:

(show all 18)

id	Title	Authors	Year	Affiliating Genes
1	Association of ARTS1 gene polymorphisms with ankylosi ng spondylitis in the Hungarian population: the rs27044 variant is associated w ith HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis. (20032103)	PazA!r B.... PoA^r G.	2010	TNFRSF1A, ERAP1, HLA-B
2	Otosclerosis or congenital stapes ankylosis? The diag nostic role of genetic analysis. (19471170)	Emery S.B.... Lesperance M.M.	2009	NOG
3	Oxygen tension regulates the expression of ANK (progr essive ankylosis) in an HIF-1-dependent manner in growth plate chondrocytes. (19419319)	Zaka R.... Williams C.J.	2009	HIF1A, SETD2, ANKH
4	Progressive ankylosis gene (ank) regulates osteoblast differentiation. (18728347)	Kirsch T.... Winkles J.A.	2009	ANKH, SP7
5	Osteoprotegerin plasma levels are strongly associated with polymorphisms in human homologue of the mouse progressive ankylosis (ANKH) gene. (17147692)	Vistoropsky Y.... Livshits G.	2007	TNFRSF11B, ANKH
6	Role of the progressive ankylosis gene in cartilage mineralization. (16462526)	Zaka R.... Williams C.J.	2006	ANKH
7	Stapes ankylosis in a family with a novel NOG mutation: otologic features of the facioaudiosymphalangism syndrome. (16151340)	Declau F.... Mattelaer P.	2005	NOG
8	Formation and resolution of ankylosis under application of recombinant human bone morphogenetic protein-2 (rhBMP-2) to class III furcation defects in cats. (15966907)	Takahashi D.... Kato H.	2005	BMP2
9	Role of the progressive ankylosis gene (ank) in cartilage mineralization. (15601852)	Wang W.... Kirsch T.	2005	SLC20A2, ANKH
10	Characterization of a stapes ankylosis family with a NOG mutation. (12621334)	Brown D.J.... Lesperance M.M.	2003	NOG
11	Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. (12089654)	Brown D.J.... Lesperance M.M.	2002	NOG
12	Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. (11326272)	Nuernberg P.... Tinschert S.	2001	ANKH
13	Polypeptide growth factors and phorbol ester induce progressive ankylosis (ank) gene expression in murine and human fibroblasts. (11746513)	Guo Y.... Winkles J.A.	2001	ANKH
14	HLA-B27 has no effect on the phenotypic expression of progressive ankylosis in ank/ank mice. (10813297)	Krug H.E.... Taurog J.D.	2000	ANKH
15	Effects of occlusal loading on ankylosis, bone, and cementum formation during bone morphogenetic protein-2-stimulated periodontal regeneration in vivo. (10534065)	King G.N.... Hughes F.J.	1999	BMP2
16	A recessive mutation leading to vertebral ankylosis in zebrafish is associated with amino acid alterations in the homologue of the human membrane-associated guanylate kinase DLG3. (10446262)	Konig C.... Campos-Ortega J.A.	1999	GUK1
17	Fibroblasts from mice with progessive ankylosis proliferate excessively in response to transforming growth factor-beta 1. (9635372)	Krug H.E.	1998	TGFB1, ANKH
18	Primary tooth ankylosis: report of case with histolog ical analysis. (7560370)	Mancini G.... Romagnoli P.	1995	DSPP

Genes related to ankylosis according to GeneCards:

(show all 29)

id	Symbol	Description	Score	GeneCards Section Context
1	ANKH	ankylosis, progressive homolog (mouse)	11.1	Proteins, Summaries, Orthologs, Domains & Families (show all 7 sections) Aliases & Descriptions, Transcripts, Publications
2	DSPP	dentin sialophosphoprotein	11.0	Publications
3	NOG	noggin	11.0	Publications
4	MARS2	methionyl-tRNA synthetase 2, mitochondrial	11.0	Disorders
5	GDF7	growth differentiation factor 7	11.0
6	TRAPPC4	trafficking protein particle complex 4	11.0
7	DLX2	distal-less homeobox 2	11.0
8	SP7	Sp7 transcription factor	11.0	Publications
9	GUK1	guanylate kinase 1	11.0	Publications
10	HEBP1	heme binding protein 1	11.0
11	ERAP1	endoplasmic reticulum aminopeptidase 1	11.0	Publications
12	GDF5	growth differentiation factor 5	11.0
13	FGFR1OP	FGFR1 oncogene partner	11.0
14	SLC20A2	solute carrier family 20 (phosphate transporter), member 2	11.0	Publications
15	TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	11.0
16	ACVR1	activin A receptor, type I	11.0
17	PTH1R	parathyroid hormone 1 receptor	11.0
18	BMP2	bone morphogenetic protein 2	11.0	Publications
19	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	11.0
20	SPP1	secreted phosphoprotein 1	11.0
21	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
22	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
23	SETD2	SET domain containing 2	11.0	Publications
24	NOTCH1	notch 1	11.0
25	FGFR2	fibroblast growth factor receptor 2	11.0
26	FGFR1	fibroblast growth factor receptor 1	11.0
27	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
28	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
29	TGFB1	transforming growth factor, beta 1	11.0	Publications

Pathways related to ankylosis according to GeneDecks:

(show top 50)    (show all 53)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.6	GDF5
2	Human Embryonic Stem Cell Pluripotency36	9.8	BMP2, FGFR2, NOG
3	eIF2 Pathway36	9.6	GDF5, FGFR2, FGFR1
4	Factors Promoting Cardiogenesis in Vertebrates36	9.5	BMP2, NOG, ACVR1, TGFB1
5	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.5	TNFRSF11B, PTH1R, SPP1
6	PTEN Pathway36	9.4	BMP2, FGFR1, FGFR2, GDF5
7	TGF-beta signaling pathway20	9.4	BMP2, GDF7, GDF5, TGFB1, ACVR1, NOG
8	PPAR Pathway36	9.1	GDF5, TNFRSF1A, FGFR2, FGFR1, BMP2
9	Cytokine-cytokine receptor interaction20	9.0	GDF5, TGFB1, ACVR1, TNFRSF1A, TNFRSF11B, BMP2
10	p53 Mediated Apoptosis36	8.9	GDF5, TGFB1, FGFR2, FGFR1, BMP2
11	Telomerase Components in Cell Signaling36	8.9	GDF5, TGFB1, FGFR2, FGFR1, BMP2
12	Mitochondrial Apoptosis36	8.9	GDF5, TGFB1, FGFR2, FGFR1, BMP2
13	DHA Signaling36	8.9	GDF5, TGFB1, FGFR2, FGFR1, BMP2
14	ERK5 Signaling36	8.9	BMP2, FGFR1, FGFR2, TGFB1, GDF5
15	Nanog in Mammalian ESC Pluripotency36	8.8	BMP2, FGFR1, FGFR2, TGFB1, GDF5
16	Rac1 Pathway36	8.8	GDF5, TGFB1, FGFR2, FGFR1, BMP2
17	p70S6K Signaling36	8.8	GDF5, TGFB1, FGFR2, FGFR1, BMP2
18	IP3 Pathway36	8.8	GDF5, TGFB1, FGFR2, FGFR1, BMP2
19	Activation of PKC through GPCR36	8.8	BMP2, FGFR1, FGFR2, TGFB1, GDF5
20	Paxillin Interactions36	8.8	GDF5, TGFB1, FGFR2, FGFR1, BMP2
21	Renin-Angiotensin Pathway36	8.8	BMP2, FGFR1, FGFR2, TGFB1, GDF5
22	Rap1 Pathway36	8.7	GDF5, TGFB1, FGFR2, FGFR1, BMP2
23	Ras Pathway36	8.7	GDF5, TGFB1, FGFR2, FGFR1, BMP2
24	Nuclear Receptor Activation by Vitamin-A36	8.7	GDF5, TAF1, TGFB1, FGFR2, FGFR1, BMP2
25	Estrogen Pathway36	8.7	GDF5, TAF1, TGFB1, FGFR2, FGFR1, BMP2
26	eNOS Signaling36	8.7	GDF5, TGFB1, FGFR2, FGFR1, BMP2
27	Apoptotic Pathways in Synovial Fibroblasts36	8.6	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
28	NF-KappaB (p50-p65) Pathway36	8.6	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
29	NF-KappaB Family Pathway36	8.6	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
30	Cellular Apoptosis Pathway36	8.6	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
31	CREB Pathway36	8.6	BMP2, FGFR1, FGFR2, TGFB1, GDF5
32	14-3-3 Induced Intracellular Signaling36	8.6	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
33	TGF-Beta Pathway36	8.6	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
34	NFAT in Immune Response36	8.6	GDF5, TGFB1, FGFR2, FGFR1, BMP2
35	JNK Pathway36	8.6	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
36	MAPK Family Pathway36	8.6	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
37	JAK-STAT Pathway36	8.5	GDF5, TGFB1, TNFRSF1A, FGFR2, FGFR1, BMP2
38	Phospholipase-C Pathway36	8.5	GDF5, TGFB1, SPP1, FGFR2, FGFR1, BMP2
39	Pancreatic Adenocarcinoma36	8.5	GDF5, TGFB1, NOTCH1, FGFR2, FGFR1, BMP2
40	GPCR Pathway36	8.5	BMP2, FGFR1, FGFR2, TGFB1, GDF5
41	Tec Kinases Signaling36	8.4	GDF5, TGFB1, ACVR1, TNFRSF1A, FGFR2, FGFR1
42	Antioxidant Action of Vitamin-C36	8.4	GDF5, TGFB1, ACVR1, TNFRSF1A, FGFR2, FGFR1
43	p38 Signaling36	8.3	GDF5, TGFB1, ACVR1, TNFRSF1A, FGFR2, FGFR1
44	Akt Signaling36	8.3	GDF5, TGFB1, ACVR1, TNFRSF1A, FGFR2, FGFR1
45	ILK Signaling36	8.3	GDF5, HIF1A, TNFRSF1A, FGFR2, FGFR1, BMP2
46	MAPK Signaling36	8.3	GDF5, TGFB1, SPP1, TNFRSF1A, FGFR2, FGFR1
47	Epithelial Adherens Junctions36	8.3	GDF5, TGFB1, NOTCH1, FGFR1, BMP2
48	Rho Family GTPases36	8.2	GDF5, TGFB1, SPP1, FGFR2, FGFR1, BMP2
49	Angiogenesis3	8.2	TGFB1, HIF1A, NOTCH1, FGFR2, FGFR1
50	Molecular Mechanisms of Cancer36	6.9	GDF5, TGFB1, HIF1A, ACVR1, NOTCH1, SPP1

Compounds related to ankylosis according to GeneDecks:

(show top 50)    (show all 86)

id	Compound	Score	Top Affiliating Genes
1	methylmethacrylate32	10.1	DSPP, SPP1, BMP2
2	alizarin32	10.0	SPP1, SP7, BMP2
3	rapamycin32 42	10.8	ENPP1, BMP2
4	lysine32	9.8	ENPP1, TNFRSF11B, TAF1
5	h2o232	9.8	DSPP, TNFRSF1A, FGFR2
6	hydroxyapatite32	9.4	DSPP, SPP1, TNFRSF11B, ANKH, ENPP1, BMP2
7	ly29400232	9.2	TGFB1, NOTCH1, SPP1, TNFRSF11B
8	pyrophosphate32 18	10.2	SPP1, TNFRSF11B, MARS2, ANKH, ENPP1, GUK1
9	threonine32	9.2	ACVR1, PTH1R, FGFR2, FGFR1, BMP2
10	1,25 dihydroxy vitamin d332	9.1	TGFB1, SPP1, PTH1R, TNFRSF11B, BMP2
11	procollagen32	9.0	BMP2, TNFRSF11B, SPP1, TGFB1
12	heparan sulfate32 18	9.8	NOG, SPP1, TNFRSF11B, FGFR2, FGFR1, BMP2
13	pge232	8.8	HIF1A, SPP1, TNFRSF11B, BMP2, SETD2
14	ns 39832 42	9.8	TGFB1, HIF1A, TNFRSF1A, TNFRSF11B
15	tgf beta132	8.8	TGFB1, SPP1, TNFRSF1A, TNFRSF11B, BMP2, SETD2
16	calcitriol32 42 9 18 9	12.7	TGFB1, DSPP, SPP1, PTH1R, TNFRSF1A, TNFRSF11B
17	estrogen32	8.6	DSPP, HIF1A, PTH1R, FGFR2, BMP2, SETD2
18	vitamin d32	8.6	TGFB1, DSPP, SPP1, PTH1R, TNFRSF11B, FGFR2
19	ascorbic acid32 18	9.5	DSPP, HIF1A, SPP1, SP7, TNFRSF11B, BMP2
20	dihydrotestosterone32 9 18 9	11.3	TGFB1, HIF1A, TNFRSF11B, BMP2, SETD2
21	matrigel32	8.1	BMP2, PTH1R, SPP1, NOTCH1, HIF1A, TGFB1
22	heparin32 9 18 9	11.1	NOG, SPP1, TNFRSF1A, TNFRSF11B, FGFR2, FGFR1
23	creatinine32	8.0	TGFB1, SPP1, TNFRSF1A, TNFRSF11B, HLA-B, GUK1
24	cycloheximide32	7.7	TGFB1, HIF1A, NOG, SPP1, TNFRSF1A, TNFRSF11B
25	alanine32	7.7	SLC20A2, TAF1, TGFB1, DSPP, HIF1A, SPP1
26	tacrolimus32 34 9 9	10.6	TGFB1, HIF1A, SPP1, HLA-B, BMP2
27	paclitaxel32 34 9 9	10.6	TGFB1, HIF1A, TNFRSF1A, FGFR2, FGFR1, SETD2
28	paraffin32	7.6	TGFB1, DSPP, HIF1A, SPP1, TNFRSF1A, HLA-B
29	doxorubicin32 34 9 9	10.6	TGFB1, HIF1A, NOTCH1, TNFRSF1A, TNFRSF11B, FGFR2
30	pd 98,05932	7.6	TGFB1, HIF1A, SPP1, FGFR2, FGFR1, BMP2
31	cyclosporin a32 42	8.6	BMP2, HLA-B, TNFRSF11B, TNFRSF1A, SPP1, HIF1A
32	ribonucleic acid32	7.5	TGFB1, NOG, SPP1, PTH1R, TNFRSF1A, HLA-B
33	sb 20358032 42	8.4	TGFB1, HIF1A, SPP1, TNFRSF1A, TNFRSF11B, FGFR1
34	proline32	7.4	TAF1, HIF1A, NOTCH1, SPP1, PTH1R, HLA-B
35	genistein32 9 18 9	10.4	HIF1A, NOTCH1, SPP1, TNFRSF11B, FGFR2, FGFR1
36	lactate32	7.3	TGFB1, DSPP, HIF1A, SPP1, HLA-B, FGFR1
37	cysteine32	7.3	GDF5, DSPP, HIF1A, NOG, SPP1, TNFRSF1A
38	phosphatidylinositol32	7.0	HIF1A, NOTCH1, SPP1, TNFRSF1A, TNFRSF11B, ENPP1
39	testosterone32 9 18 9	9.8	HIF1A, SPP1, TNFRSF1A, TNFRSF11B, HLA-B, FGFR2
40	lipid32	6.8	NOTCH1, SPP1, TNFRSF1A, TNFRSF11B, HLA-B, ENPP1
41	oligonucleotide32	6.7	TGFB1, HIF1A, ACVR1, SPP1, HLA-B, FGFR2
42	atp32	6.6	TNFRSF11B, TNFRSF1A, SPP1, HIF1A, HLA-B, ENPP1
43	glucose32	6.5	TNFRSF11B, TNFRSF1A, SPP1, HIF1A, HLA-B, ENPP1
44	nitric oxide32 9 18 9	9.5	HIF1A, NOTCH1, PTH1R, TNFRSF1A, TNFRSF11B, HLA-B
45	dexamethasone32 42 34 9 9	10.3	NOG, NOTCH1, HIF1A, DSPP, TGFB1, SPP1
46	vegf32	6.1	SPP1, NOG, NOTCH1, HIF1A, TGFB1, SP7
47	calcium32 9 18 9	8.7	PTH1R, SP7, SPP1, NOG, NOTCH1, ACVR1
48	tyrosine32	5.6	GDF5, HIF1A, NOTCH1, NOG, SPP1, TNFRSF1A
49	retinoic acid32 42 18	7.6	SPP1, NOG, NOTCH1, HIF1A, TGFB1, PTH1R
50	serine32	4.3	SETD2, NOG, NOTCH1, ACVR1, HIF1A, DSPP

Cellular components related to ankylosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane-bounded vesicle	GO:031988	9.9	BMP2, SPP1
2	cell surface	GO:009986	8.3	TGFB1, TNFRSF1A, ENPP1, FGFR2, BMP2
3	extracellular space	GO:005615	8.0	BMP2, GDF7, GDF5, TGFB1, NOG, SPP1
4	integral to plasma membrane	GO:005887	7.6	SLC20A2, ACVR1, PTH1R, TNFRSF1A, HLA-B, ANKH
5	extracellular region	GO:005576	6.8	TGFB1, HEBP1, NOTCH1, NOG, SPP1, TNFRSF1A

Biological processes related to ankylosis according to GeneDecks:

(show all 42)

id	Name	GO ID	Score	Top Affiliating Genes
1	osteoblast differentiation	GO:001649	10.6	SP7, NOG
2	growth	GO:040007	10.2	GDF7, GDF5, BMP2
3	biomineral tissue development	GO:031214	10.1	ENPP1, SPP1, DSPP
4	branching morphogenesis of a nerve	GO:048755	10.1	DLX2, FGFR2
5	reproductive structure development	GO:048608	10.1	GDF7, FGFR2
6	BMP signaling pathway	GO:030509	10.1	GDF7, ACVR1, NOG, BMP2
7	gland morphogenesis	GO:022612	10.1	FGFR2, GDF7
8	cell fate commitment	GO:045165	9.9	GDF7, FGFR2, BMP2
9	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	GO:035607	9.9	FGFR1, FGFR2
10	positive regulation of odontogenesis	GO:042482	9.9	BMP2, TGFB1
11	bone mineralization	GO:030282	9.9	PTH1R, FGFR2, BMP2
12	ventricular zone neuroblast division	GO:021847	9.8	FGFR2, FGFR1
13	positive regulation of bone mineralization	GO:030501	9.8	TGFB1, ACVR1, BMP2
14	pathway-restricted SMAD protein phosphorylation	GO:060389	9.7	GDF7, TGFB1, ACVR1, BMP2
15	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	9.7	BMP2, ACVR1, TGFB1, GDF7
16	atrioventricular valve morphogenesis	GO:003181	9.7	NOTCH1, BMP2
17	midbrain development	GO:030901	9.7	GDF7, FGFR2, FGFR1
18	negative regulation of osteoblast differentiation	GO:045668	9.7	NOTCH1, NOG, FGFR1
19	positive regulation of epithelial to mesenchymal transition	GO:010718	9.7	TGFB1, NOTCH1, BMP2
20	negative regulation of ossification	GO:030279	9.7	TGFB1, NOTCH1, ENPP1
21	mesenchymal cell differentiation	GO:048762	9.6	FGFR2, FGFR1, BMP2
22	positive regulation of phospholipase activity	GO:010518	9.6	FGFR1, FGFR2
23	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061419	9.6	HIF1A, NOTCH1
24	chondrocyte differentiation	GO:002062	9.5	FGFR1, PTH1R, TGFB1
25	positive regulation of epithelial cell proliferation	GO:050679	9.5	TGFB1, NOG, FGFR2
26	lung-associated mesenchyme development	GO:060484	9.5	FGFR2, FGFR1
27	positive regulation of cardiac muscle cell proliferation	GO:060045	9.5	NOTCH1, FGFR2, FGFR1
28	connective tissue replacement involved in inflammatory response wound healing	GO:002248	9.4	TGFB1, HIF1A
29	positive regulation of cell migration	GO:030335	9.4	BMP2, FGFR1OP, NOTCH1, TGFB1
30	cartilage development	GO:051216	9.3	GDF5, HIF1A, NOG, DLX2, BMP2
31	ureteric bud development	GO:001657	9.2	FGFR1, FGFR2, TGFB1
32	in utero embryonic development	GO:001701	9.2	BMP2, FGFR1, FGFR2, NOG, ACVR1
33	positive regulation of neuron differentiation	GO:045666	9.2	BMP2, FGFR1, GDF7
34	skeletal system development	GO:001501	9.1	BMP2, FGFR1, ANKH, TNFRSF11B, PTH1R, NOG
35	epithelial to mesenchymal transition	GO:001837	8.7	TGFB1, HIF1A, NOTCH1, NOG, BMP2
36	virus-host interaction	GO:019048	8.6	SLC20A2, TAF1, TGFB1, TNFRSF1A, HLA-B
37	response to hypoxia	GO:001666	8.5	BMP2, TNFRSF1A, HIF1A, TGFB1
38	angiogenesis	GO:001525	8.5	SETD2, FGFR1, FGFR2, ERAP1, HIF1A
39	positive regulation of cell proliferation	GO:008284	8.5	TGFB1, NOTCH1, PTH1R, FGFR2, FGFR1OP, FGFR1
40	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.4	TGFB1, NOTCH1, NOG, DLX2, FGFR2, FGFR1
41	positive regulation of transcription, DNA-dependent	GO:045893	8.3	GDF7, TGFB1, HIF1A, ACVR1, NOTCH1, BMP2
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.3	TAF1, TGFB1, HIF1A, ACVR1, NOTCH1, NOG

Molecular functions related to ankylosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	inorganic phosphate transmembrane transporter activity	GO:005315	10.0	ANKH, SLC20A2
2	growth factor activity	GO:008083	9.3	BMP2, TGFB1, GDF5, GDF7
3	cytokine activity	GO:005125	9.2	GDF7, GDF5, SPP1, TNFRSF11B, BMP2
4	fibroblast growth factor-activated receptor activity	GO:005007	9.2	FGFR2, FGFR1
5	protein homodimerization activity	GO:042803	7.7	BMP2, GDF7, TGFB1, ACVR1, NOG, ENPP1