Aliases & Classifications for Ankylosis

MalaCards integrated aliases for Ankylosis:

Name: Ankylosis 12 72 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:227
ICD10 32 M24.6
ICD9CM 34 718.5 718.50
MeSH 41 D000844
UMLS 69 C0003090

Summaries for Ankylosis

Disease Ontology : 12 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary : Ankylosis is related to fibrodysplasia ossificans progressiva and auriculocondylar syndrome 1, and has symptoms including joint symptom, joint stiffness and metatarsalgia. An important gene associated with Ankylosis is ANKH (ANKH Inorganic Pyrophosphate Transport Regulator), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Celecoxib and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and endothelial, and related phenotypes are Decreased IL-13 protein expression and cardiovascular system

Wikipedia : 72 Ankylosis or anchylosis (from Greek ἀγκύλος, bent, crooked) is a stiffness of a joint due to abnormal... more...

Related Diseases for Ankylosis

Diseases related to Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 fibrodysplasia ossificans progressiva 31.8 ACVR1 BMP4 NOG
2 auriculocondylar syndrome 1 31.7 GNAI3 PLCB4
3 spondyloarthropathy 1 31.3 ANKH BGLAP TNFRSF11B
4 proximal symphalangism 31.2 BMP2 BMP4 NOG
5 pfeiffer syndrome 31.1 FGFR2 RUNX2 SP7
6 craniometaphyseal dysplasia, autosomal dominant 29.4 ACVR1 ANKH SP7
7 otosclerosis 28.7 BMP2 BMP4 NOG TNFRSF11B
8 osseous heteroplasia, progressive 28.0 ACVR1 BGLAP BMP2 BMP4 NOG RUNX2
9 osteoporosis 26.9 BGLAP BMP2 IBSP NOG RUNX2 SP7
10 tooth ankylosis 12.4
11 stapes ankylosis with broad thumbs and toes 12.3
12 temporomandibular ankylosis 12.3
13 permanent molars, secondary retention of 12.1
14 congenital temporomandibular joint ankylosis 12.0
15 glossopalatine ankylosis 12.0
16 craniostenosis, sagittal, with congenital heart disease, mental deficiency, and mandibular ankylosis 11.9
17 glossopalatine ankylosis micrognathia ear anomalies 11.8
18 arthropathy 11.8
19 cardiocranial syndrome 11.5
20 deafness, progressive, with stapes fixation 11.0
21 restrictive dermopathy, lethal 11.0
22 auriculocondylar syndrome 2 11.0
23 pseudoarthrogryposis 10.8
24 distal arthrogryposis 10.8
25 johnson hall krous syndrome 10.8
26 piussan lenaerts mathieu syndrome 10.8
27 hypoglossia-hypodactylia 10.8
28 syngnathia 10.8
29 symphalangism, distal 10.8
30 symphalangism, proximal, 1a 10.8
31 auriculocondylar syndrome 3 10.8
32 multiple synostoses syndrome 10.8
33 charlie m syndrome 10.8
34 humeroradial synostosis 10.3 FGFR2 NOG
35 auriculo-condylar syndrome 10.3 GNAI3 PLCB4
36 arthritis 10.3
37 inflammatory spondylopathy 10.3
38 spondylitis 10.3
39 rheumatoid arthritis 10.1
40 spondyloarthropathy 10.0
41 septic arthritis 10.0
42 alveolar periostitis 10.0 BGLAP RUNX2
43 cervicitis 10.0
44 brachydactyly 9.9 BMP2 NOG RUNX2
45 blood group, i system 9.9
46 psoriatic arthritis 9.9
47 sleep apnea 9.9
48 laryngitis 9.9
49 apnea, obstructive sleep 9.9
50 myositis 9.9

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to Ankylosis

Symptoms & Phenotypes for Ankylosis

UMLS symptoms related to Ankylosis:


joint symptom, joint stiffness, metatarsalgia, arthralgia

GenomeRNAi Phenotypes related to Ankylosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased IL-13 protein expression GR00219-A 8.62 ACVR1 FGFR2

MGI Mouse Phenotypes related to Ankylosis:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 GNAI3 RUNX2 NOG FGFR2 BMP2 ACVR1
2 cellular MP:0005384 10.18 FGFR2 RUNX2 SP7 NOG BMP2 ACVR1
3 growth/size/body region MP:0005378 10.18 PLCB4 RUNX2 IBSP NOG FGFR2 BMP2
4 craniofacial MP:0005382 10.16 RUNX2 IBSP NOG BMP2 ACVR1 BMP4
5 homeostasis/metabolism MP:0005376 10.06 NOG FGFR2 GNAI3 RUNX2 SP7 BMP2
6 digestive/alimentary MP:0005381 10.04 RUNX2 IBSP NOG FGFR2 BMP2 ACVR1
7 hematopoietic system MP:0005397 10.03 FGFR2 GNAI3 RUNX2 IBSP BMP2 BMP4
8 limbs/digits/tail MP:0005371 10.02 RUNX2 IBSP NOG SP7 BMP2 ACVR1
9 hearing/vestibular/ear MP:0005377 10 NOG FGFR2 BMP2 ACVR1 BMP4 ANKH
10 immune system MP:0005387 9.97 FGFR2 GNAI3 RUNX2 IBSP BMP2 ACVR1
11 mortality/aging MP:0010768 9.96 FGFR2 PLCB4 RUNX2 SP7 NOG BMP2
12 muscle MP:0005369 9.7 PLCB4 RUNX2 NOG FGFR2 ACVR1 BMP4
13 respiratory system MP:0005388 9.43 NOG FGFR2 RUNX2 SP7 BMP4 ANKH
14 skeleton MP:0005390 9.4 PLCB4 RUNX2 GNAI3 IBSP NOG SP7

Drugs & Therapeutics for Ankylosis

Drugs for Ankylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
2
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
3
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5359476 5353980
4
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
5
Pamidronate Approved Phase 4 40391-99-9 4674
6
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
7
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
8
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
9
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
10
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
11
Aceclofenac Approved, Investigational Phase 4 89796-99-6
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Hydroxychloroquine Approved Phase 4 118-42-3 3652
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
16
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
17 Analgesics Phase 4,Phase 2,Phase 3
18 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
19 Anti-Infective Agents Phase 4,Phase 2,Phase 3
20 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
21 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
22 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
24 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
25 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
26 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
28 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Natriuretic Agents Phase 4
30 Natriuretic Peptide, Brain Phase 4
31 Antimetabolites Phase 4,Phase 3,Phase 2
32 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
33 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
34 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
35 Vitamin B Complex Phase 4,Phase 3,Phase 2
36 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
37 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
38 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
39 Vaccines Phase 4,Phase 2
40 Bone Density Conservation Agents Phase 4
41 Endothelial Growth Factors Phase 4
42 Mitogens Phase 4
43 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
44 Antibiotics, Antitubercular Phase 4
45 Anticholesteremic Agents Phase 4
46 Cholestyramine Resin Phase 4
47 Hypolipidemic Agents Phase 4
48 Lipid Regulating Agents Phase 4
49 Analgesics, Opioid Phase 4
50 Central Nervous System Depressants Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 299)

# Name Status NCT ID Phase Drugs
1 Gait Analysis of Ankle Arthroplasty and Arthrodesis Unknown status NCT00921076 Phase 4
2 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
3 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
4 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
5 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
6 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
7 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
8 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
9 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
10 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
11 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
12 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4 Enbrel
13 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
14 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
15 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4 alendronate
16 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
17 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
18 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
19 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
20 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
21 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
22 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4 Infliximab; observational study;Methotrexate; observational study
23 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
24 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
25 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
26 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4 Etanercept
27 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
28 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
29 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
30 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
31 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
32 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
33 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
34 Study Investigating Enbrel Treatment for Ankylosing Spondylitis Completed NCT00195416 Phase 4 Etanercept
35 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
36 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
37 Sequential Application of Yisaipu® and DMARDs in Treating Mild-to-Moderate AS Recruiting NCT03411798 Phase 4 Yisaipu®
38 A Randomized, Double-blind, Placebo-controlled Multicenter Study of Secukinumab (AIN457) to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylit Recruiting NCT02763046 Phase 4 AIN457/Secukinumab Placebo
39 NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in Ankylosing Spondylitis Recruiting NCT02758782 Phase 4 Celecoxib
40 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Recruiting NCT02634541 Phase 4 Adalimumab
41 Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA Recruiting NCT02509026 Phase 4
42 Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients Recruiting NCT02492217 Phase 4 Adalimumab
43 Delaying Ossification and Improving Inflammation of Celebrex Plus/or Enbrel Treatment on Active Ankylosing Spondylitis Active, not recruiting NCT01934933 Phase 4 celebrex;Enbrel;Enbrel plus Celebrex
44 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Not yet recruiting NCT03190603 Phase 4 Celecoxib
45 Study Estimating the Clinical Difference Between 300 mg and 150 mg of Secukinumab Following Dose Escalation to 300 mg in Patients With Ankylosing Spondylitis Not yet recruiting NCT03350815 Phase 4 150 mg open-label secukinumab;150 mg double-blinded secukinumab;300 mg double-blinded secukinumab
46 Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem Terminated NCT01422564 Phase 4
47 Effects of Etanercept on the Heart, Veins and Thickness of Certain Major Arteries In Ankylosing Spondylitis Patients Terminated NCT00910273 Phase 4 etanercept
48 Enthesitis With Ultra Sonography Doppler in Spondyloarthropathies Treated With Infliximab (Study P04440) Terminated NCT00686894 Phase 4 Infliximab
49 An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs) Terminated NCT00766402 Phase 4 Tramadol /acetaminophen;Diclofenac
50 A Study to Assess the Safety and Effectiveness of Golimumab in Filipino Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Withdrawn NCT01692457 Phase 4 No intervention

Search NIH Clinical Center for Ankylosis

Cochrane evidence based reviews: ankylosis

Genetic Tests for Ankylosis

Anatomical Context for Ankylosis

MalaCards organs/tissues related to Ankylosis:

38
Bone, Testes, Endothelial, T Cells, Heart, Skin, Brain

Publications for Ankylosis

Articles related to Ankylosis:

(show top 50) (show all 682)
# Title Authors Year
1
Cricoarytenoid Joint Ankylosis: Classification and Transoral Laser Microsurgical Treatment. ( 29306525 )
2018
2
Monitoring of incremental changes in maximum interincisal opening after gap arthroplasty omits the risk of Re-ankylosis. ( 29037918 )
2018
3
Evaluation of Hemoglobin Concentration and Hematocrit Values in Temporomandibular Joint Ankylosis Patients in Comparison to Nonankylosed Patients. ( 29422472 )
2018
4
Orthognathic treatment of facial asymmetry due to temporomandibular joint ankylosis. ( 29076326 )
2018
5
Interpositional Arthroplasty by Temporalis Fascia Flap and Galea Aponeurotica Combined With Distraction Osteogenesis: a Modified Method in Treatment of Adult Patients With Temporomandibular Joint Ankylosis and Mandibular Dysplasia. ( 29303852 )
2018
6
Management of Temporomandibular Joint Ankylosis With Dentofacial Deformities in Children. ( 29381640 )
2018
7
Double non-contiguous fractures in a patient with spondylo-epiphyseal dysplasia with spinal ankylosis treated with open and percutaneous spinal fixation technique: a case report. ( 29415765 )
2018
8
Augmentation surgery on the cartilaginous portion of the vocal fold in a patient with cricoarytenoid joint ankylosis. ( 29307442 )
2018
9
The First Record of Incidences of Ankylosis in Seven Triplefin Fishes (Pisces: Tripterygiidae) from New Zealand. ( 29059718 )
2018
10
A Bone Conduction Implantable Device as a Functional Treatment Option in Unilateral Microtia with Bilateral Stapes Ankylosis: A Report of Two Cases. ( 29358571 )
2018
11
Grafts of autogenous coronoid process to reconstruct the mandibular condyle in children with unilateral ankylosis of the temporomandibular joint: long-term effects on mandibular growth. ( 29254874 )
2018
12
Use of Kerrison Rongeur for safe and effective removal of bone in temporomandibular joint ankylosis. ( 29340886 )
2018
13
A Case of Glenoid Fossa Fracture, Progressive Ankylosis, Total Joint Reconstruction with Alloplastic Prosthesis to Normalized Function Including Evaluation with F18-PET/CT-a Four Year Follow-up. ( 28210410 )
2017
14
Airway management of a paediatric patient with temporomandibular joint ankylosis with extra hepatic portal vein obstruction, splenomegaly, hypersplenism, and obstructive sleep apnoea for shunt surgery: A unique challenge. ( 29217866 )
2017
15
Formation of Condyle-Like Structure after Treatment of Temporomandibular Joint Ankylosis: Literature Review and Long-Term Follow-Up of Two Patients. ( 29098006 )
2017
16
Simultaneous treatment of temporomandibular joint ankylosis with severe mandibular deficiency by standard TMJ prosthesis. ( 28337986 )
2017
17
3-D computed tomography measurement of mandibular growth after costochondral grafting in growing children with temporomandibular joint ankylosis and jaw deformity. ( 28739355 )
2017
18
Ankylosis of the Temporomandibular Joint and Reconstruction With a Costochondral Graft in a Patient With Juvenile Idiopathic Arthritis. ( 27930467 )
2017
19
Three-dimensional reconstructions of CT scans and cone beam CT of impacted maxillary canines in order to locate areas of ankylosis before orthodontic traction. ( 29108751 )
2017
20
Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis. ( 28743287 )
2017
21
Application of a computer-assisted surgical navigation system in temporomandibular joint ankylosis surgery: a retrospective study. ( 27839946 )
2017
22
Results and outcome predictors after open release of complete ankylosis of the elbow caused by heterotopic ossification. ( 28083670 )
2017
23
A preliminary study of effects of low-intensity pulsed ultrasound (LIPUS) irradiation on dentoalveolar ankylosis. ( 28904322 )
2017
24
Simultaneous Reconstruction of Both Facial Paralysis and Temporomandibular Joint Ankylosis With a Composite Flap From Dorsum of Foot. ( 28891897 )
2017
25
Temporomandibular Joint Ankylosis After Early Mandibular Distraction Osteogenesis: A New Syndrome? ( 28538064 )
2017
26
Re-Assessment of Coronoid as a Graft for Condylar Reconstruction in TMJ Ankylosis Patients: A Prospective Study and Literature Review. ( 28439157 )
2017
27
Prophylactic embolisation of the internal maxillary artery in patients with ankylosis of the temporomandibular joint. ( 28372882 )
2017
28
Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study. ( 29016762 )
2017
29
Ankylosis of the Finger in Erosive Osteoarthritis. ( 28090062 )
2017
30
Bilateral pediatric mandibular distraction for micrognathia with temporomandibular joint ankylosis and sleep apnea. ( 29072225 )
2017
31
Ankylosis of temporomandibular joints after mandibular distraction osteogenesis in patients with Nager syndrome: Report of two cases and literature review. ( 28688869 )
2017
32
Ankylosis of the knee after septic arthritis following anterior cruciate ligament reconstruction in a 13-year-old male. ( 28342819 )
2017
33
Miniscrew-Supported Orthodontic Pseudo-Ankylosis for Mesialization of a Lower Third Molar. ( 28668944 )
2017
34
Use of Temporalis Fascia Flap in the Treatment of Temporomandibular Joint Ankylosis: A Clinical Audit of 5 Years. ( 29042715 )
2017
35
Food Choking in a Patient with Congenital Temporomandibular Joint Ankylosis. ( 29359080 )
2017
36
Micrognathia with temporomandibular joint ankylosis and obstructive sleep apnea treated with mandibular distraction osteogenesis using skeletal anchorage: a case report. ( 29126455 )
2017
37
Cone-beam computed tomography evaluation of the maxillofacial features of patients with unilateral temporomandibular joint ankylosis undergoing condylar reconstruction with an autogenous coronoid process graft. ( 28257487 )
2017
38
Neocondyle distraction osteogenesis in the management of temporomandibular joint ankylosis: Report of five cases with review of literature. ( 28721990 )
2017
39
Evaluation of the condyle remodeling after lateral arthroplasty in growing children with temporomandibular joint ankylosis. ( 28855535 )
2017
40
Overgrowth of costochondral graft in temporomandibular joint ankylosis reconstruction: A retrospective study. ( 28611327 )
2017
41
Multidisciplinary management of post-ankylosis malocclusion and mandibular deformity. ( 29364827 )
2017
42
Proximal interphalangeal joint ankylosis in an early medieval horse from WrocA8aw Cathedral Island, Poland. ( 28521909 )
2017
43
Application of Bidirectional Distraction Osteogenesis for the Treatment of Mandibular Micriognathia Caused by Temporomandibular Joint Ankylosis. ( 28692514 )
2017
44
The role of the progressive ankylosis protein (ANK) in adipogenic/osteogenic fate decision of precursor cells. ( 28286238 )
2017
45
Congenital Stapes Ankylosis in Children: Surgical Findings and Results in 35 Cases. ( 26945311 )
2016
46
Improvement in the airway after mandibular distraction osteogenesis surgery in children with temporomandibular joint ankylosis and mandibular hypoplasia. ( 26909508 )
2016
47
Bony ankylosis of hydroxyapatite prostheses in the middle ear. ( 26954869 )
2016
48
An unusual anterior dislocation of fractured mandibular condyle leading to psuedo-ankylosis in a 8 yr old child-A distinct case report. ( 27448226 )
2016
49
Conservative gap arthroplasty in temporomandibular ankylosis not involving the sigmoid notch: a selected age group study. ( 26972420 )
2016
50
Supracondylar femoral osteotomy and knee joint replacement during the same surgical procedure in a type A haemophiliac patient with knee flexion deformity and ankylosis. ( 27919671 )
2016

Variations for Ankylosis

Expression for Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for Ankylosis

Pathways related to Ankylosis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 ACVR1 BMP2 BMP4 FGFR2 GNAI3 PLCB4
2
Show member pathways
13.17 ACVR1 BMP2 BMP4 FGFR2 GNAI3 PLCB4
3
Show member pathways
12.82 BMP2 BMP4 FGFR2 GNAI3 PLCB4
4 12.62 BMP2 BMP4 FGFR2 GNAI3 PLCB4
5
Show member pathways
12.14 BMP2 BMP4 GNAI3 PLCB4
6 11.9 BMP4 FGFR2 TNFRSF11B
7 11.88 ACVR1 BMP4 FGFR2
8
Show member pathways
11.88 ACVR1 BMP2 BMP4 FGFR2 GNAI3 NOG
9 11.55 ACVR1 BMP2 BMP4 NOG
10
Show member pathways
11.54 BMP2 NOG RUNX2
11 11.4 BMP4 NOG RUNX2
12 11.28 BGLAP FGFR2 RUNX2
13 11.23 BGLAP RUNX2 TNFRSF11B
14 11.19 BGLAP IBSP RUNX2
15 11.08 BGLAP BMP2 BMP4 NOG RUNX2 SP7
16 11.05 BGLAP IBSP PLCB4 RUNX2
17 11.04 GNAI3 PLCB4
18 10.98 BMP2 BMP4
19 10.92 BMP2 BMP4
20 10.58 BGLAP IBSP TNFRSF11B

GO Terms for Ankylosis

Cellular components related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 BGLAP BMP2 BMP4 FGFR2 IBSP NOG

Biological processes related to Ankylosis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.95 ACVR1 BMP2 FGFR2 NOG
2 cartilage development GO:0051216 9.86 BMP2 BMP4 NOG
3 positive regulation of epithelial cell proliferation GO:0050679 9.84 BMP4 FGFR2 NOG
4 cell fate commitment GO:0045165 9.83 BMP2 BMP4 FGFR2
5 odontogenesis of dentin-containing tooth GO:0042475 9.83 BMP2 BMP4 RUNX2
6 bone development GO:0060348 9.83 BGLAP BMP4 FGFR2
7 ossification GO:0001503 9.83 BGLAP BMP2 BMP4 RUNX2
8 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.81 ACVR1 BMP2 BMP4
9 positive regulation of osteoblast differentiation GO:0045669 9.8 ACVR1 BMP2 BMP4 RUNX2
10 ureteric bud development GO:0001657 9.79 BMP4 FGFR2 NOG
11 chondrocyte differentiation GO:0002062 9.79 BMP2 BMP4 RUNX2
12 epithelial to mesenchymal transition GO:0001837 9.78 BMP2 FGFR2 NOG
13 cellular response to growth factor stimulus GO:0071363 9.78 BGLAP BMP2 BMP4 IBSP
14 embryonic cranial skeleton morphogenesis GO:0048701 9.77 BMP4 FGFR2 RUNX2
15 mesoderm formation GO:0001707 9.76 ACVR1 BMP4 NOG
16 positive regulation of bone mineralization GO:0030501 9.75 ACVR1 BMP2 BMP4
17 odontogenesis GO:0042476 9.74 BGLAP BMP4 FGFR2
18 endoderm development GO:0007492 9.73 BMP4 NOG
19 pituitary gland development GO:0021983 9.73 BMP4 NOG
20 cardiac muscle cell differentiation GO:0055007 9.73 BMP2 BMP4
21 telencephalon development GO:0021537 9.73 BMP2 BMP4
22 endochondral ossification GO:0001958 9.73 BMP4 RUNX2
23 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.72 BMP2 BMP4
24 regulation of bone mineralization GO:0030500 9.72 ANKH BGLAP
25 lung morphogenesis GO:0060425 9.72 BMP4 NOG
26 anatomical structure formation involved in morphogenesis GO:0048646 9.72 BMP4 NOG
27 osteoblast development GO:0002076 9.71 BGLAP RUNX2
28 positive regulation of cartilage development GO:0061036 9.71 BMP2 BMP4
29 positive regulation of ossification GO:0045778 9.71 BMP2 BMP4
30 response to inorganic substance GO:0010035 9.71 BGLAP TNFRSF11B
31 regulation of osteoblast differentiation GO:0045667 9.71 FGFR2 RUNX2
32 outflow tract septum morphogenesis GO:0003148 9.71 ACVR1 BMP4 FGFR2
33 smooth muscle cell differentiation GO:0051145 9.7 ACVR1 BMP4
34 pathway-restricted SMAD protein phosphorylation GO:0060389 9.7 ACVR1 BMP2
35 regulation of ossification GO:0030278 9.7 ACVR1 RUNX2
36 mesodermal cell differentiation GO:0048333 9.7 BMP4 FGFR2
37 atrioventricular valve morphogenesis GO:0003181 9.69 ACVR1 BMP2
38 embryonic skeletal joint morphogenesis GO:0060272 9.69 BMP4 NOG
39 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.69 BMP2 RUNX2
40 endocardial cushion morphogenesis GO:0003203 9.69 ACVR1 BMP2 NOG
41 regulation of fibroblast growth factor receptor signaling pathway GO:0040036 9.68 FGFR2 RUNX2
42 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.68 BMP4 FGFR2
43 bud elongation involved in lung branching GO:0060449 9.68 BMP4 FGFR2
44 telencephalon regionalization GO:0021978 9.67 BMP2 BMP4
45 pharyngeal arch artery morphogenesis GO:0061626 9.67 BMP4 NOG
46 regulation of smooth muscle cell differentiation GO:0051150 9.66 BMP4 FGFR2
47 BMP signaling pathway GO:0030509 9.65 ACVR1 BMP2 BMP4 NOG RUNX2
48 prostate gland morphogenesis GO:0060512 9.64 BMP4 FGFR2
49 branching involved in prostate gland morphogenesis GO:0060442 9.64 BMP4 FGFR2
50 regulation of cell fate commitment GO:0010453 9.63 BMP4 FGFR2

Molecular functions related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 8.96 BMP2 BMP4
2 BMP receptor binding GO:0070700 8.62 BMP2 BMP4

Sources for Ankylosis

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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