MCID: ANK001
MIFTS: 50

Ankylosis malady

Summaries for Ankylosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. the rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards: Ankylosis is related to arthropathy and arthritis. An important gene associated with Ankylosis is ANKH (ANKH inorganic pyrophosphate transport regulator), and among its related pathways are Osteoblast Signaling and TGF-beta Signaling Pathway. The compounds methylmethacrylate and alizarin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Wikipedia:63 Ankylosis or anchylosis (from Greek ἀγκύλος, bent, crooked) is a stiffness of a joint due to... more...

Aliases & Classifications for Ankylosis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

ankylosis 8 10 60


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Disease Ontology8 DOID:227
ICD9CM27 718.50, 718.5
MeSH34 D000844

Related Diseases for Ankylosis

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17GeneCards, 18GeneDecks
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Diseases related to Ankylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 467)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy30.6ANKH, BMP2, TNFRSF11B
2arthritis30.5TNFRSF11B, BMP2, ANKH, GDF5
3ankylosing spondylitis30.5ERAP1
4fibrodysplasia ossificans progressiva30.1NOG, BMP2
5periodontitis29.9TNFRSF11B
6proximal symphalangism29.8NOG, GDF5
7otosclerosis29.8TNFRSF11B, NOG
8hypophosphatemia29.5DSPP
9cleft palate29.5BMP2, DSPP
10progressive osseous heteroplasia29.5BMP2, NOG
11root resorption29.5GDF5, BMP2, TNFRSF11B, HEBP1
12osteoarthritis29.5TNFRSF11B, BMP2, DSPP, ANKH, GDF5
13tooth ankylosis10.4
14spondylitis10.3
15temporomandibular ankylosis10.2
16rheumatoid arthritis10.1
17spondyloarthropathy10.1
18stapes ankylosis with broad thumb and toes10.1
19septic arthritis10.1
20multiple epiphyseal dysplasia10.0
21laryngitis10.0
22cardiocranial syndrome10.0
23polyarticular onset juvenile idiopathic arthritis10.0
24mucopolysaccharidosis ih10.0
25synostosis10.0NOG
26syndactyly10.0NOG, GDF5
27osteonecrosis10.0BMP2
28brachydactyly10.0NOG, GDF5
29dental enamel hypoplasia10.0HEBP1, DSPP
30osteosclerosis10.0TNFRSF11B, BMP2
31hyperphosphatemia10.0TNFRSF11B, BMP2
32osteogenesis imperfecta10.0DSPP, PTH1R, SP7
33metaphyseal dysplasia10.0PTH1R
34hypophosphatasia10.0DSPP
35craniosynostosis10.0NOG, ANKH, BMP2
36secondary syphilis10.0PTH1R, BMP2, TNFRSF11B
37aortic valve stenosis10.0BMP2, TNFRSF11B
38spondylolisthesis10.0BMP2
39osteoporosis10.0SP7, PTH1R, NOG, BMP2, TNFRSF11B
40hypertrophy of breast10.0BMP2, GDF5, NOG, PTH1R, SETD2
41breast cancer10.0TNFRSF11B, BMP2, PTH1R, SETD2
42osteosarcoma10.0TNFRSF11B, BMP2, PTH1R, SETD2, SP7
43psoriatic arthritis10.0
44noma10.0
45cervicitis10.0
46otitis media10.0
47glossopalatine ankylosis micrognathia ear anomalies10.0
48marfan syndrome9.9
49diffuse idiopathic skeletal hyperostosis9.9
50williams-beuren syndrome9.9

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to ankylosis

Clinical Features for Ankylosis

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Drugs & Therapeutics for Ankylosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ankylosis

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Anatomical Context for Ankylosis

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32MalaCards
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MalaCards organs/tissues related to Ankylosis:

32
Bone, Skin, Brain, Spleen, T cells, Tonsil

Animal Models for Ankylosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ankylosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.5TNFRSF11B, BMP2, ANKH, DLX2, NOG
2MP:00053719.4TNFRSF11B, BMP2, ANKH, GDF5, NOG, PTH1R
3MP:00053829.1SETD2, TNFRSF11B, BMP2, DSPP, ANKH, DLX2
4MP:00053908.9GNAI3, TNFRSF11B, BMP2, ANKH, GDF5, DLX2
5MP:00107688.7BMP2, ANKH, GDF5, GDF7, DLX2, NOG
6MP:00053788.6TNFRSF11B, BMP2, ANKH, GDF5, DLX2, SLC20A2

Publications for Ankylosis

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50PubMed
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Articles related to Ankylosis:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
2000 years temporomandibular joint ankylosis in ancient Rome. (23714953)
2013
2
Is aggressive gap arthroplasty essential in the management of temporomandibular joint ankylosis?-a prospective clinical study of 15 cases. (23219020)
2013
3
Two-stage total prosthetic reconstruction of temporomandibular joint in severe and recurrent ankylosis. (22976729)
2012
4
The long-term fate of pedicled buccal pad fat used for interpositional arthroplasty in TMJ ankylosis. (22695714)
2012
5
Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression. (22437419)
2012
6
Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis. (22410100)
2012
7
The development of traumatic temporomandibular joint bony ankylosis: a course similar to the hypertrophic nonunion? (22115694)
2012
8
TMJ Ankylosis: Multidisciplinary Approach of Treatment for Dentofacial Enhancement-A Case Report. (22567429)
2011
9
A modified laryngoplasty approach promoting ankylosis of the cricoarytenoid joint. (21204857)
2011
10
Management of temporomandibular joint ankylosis associated with mandibular asymmetry in infancy. (21772189)
2011
11
Management of temporomandibular ankylosis with temporal fascia inter-positional arthroplasty and distraction osteogenesis: report of 30 cases. (20666713)
2009
12
Bifid mandibular condyle with associated temporomandibular joint ankylosis: a computed tomography study of the patterns and morphological variations. (19372112)
2009
13
One stage management of ankylosis of the temporomandibular joint with a custom-made total joint replacement system. (19482389)
2009
14
Transport distraction versus costochondral graft for reconstruction of temporomandibular joint ankylosis: which is better? (19451010)
2009
15
Minimum 1-year follow-up for patients with vertical shear sacroiliac joint dislocations treated with iliosacral screws: does joint ankylosis or anatomic reduction contribute to functional outcome? (18448980)
2008
16
Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandibular ankylosis in children. (18420320)
2008
17
Use of vascularised cartilage as an additional interposition in temporomandibular ankylosis surgery: Rationale, advantages and potential benefits. (19753248)
2008
18
Treatment of temporomandibular joint ankylosis and facial asymmetry with bidirectional transport distraction osteogenesis technique. (18520391)
2008
19
Autogenous auricular cartilage graft in temporomandibular joint ankylosis--an evaluation. (18820957)
2008
20
The role of muscle grafts in temporomandibular joint ankylosis: short-term experimental study in sheep. (16730161)
2006
21
Clinical investigation of early post-traumatic temporomandibular joint ankylosis and the role of repositioning discs in treatment. (17092690)
2006
22
Intraoral distraction osteogenesis for the correction of facial deformities following temporomandibular joint ankylosis: a modified technique. (16513319)
2006
23
Treatment of TMJ ankylosis in Jordanian children - a comparison of two surgical techniques. (15694147)
2005
24
Temporomandibular joint ankylosis after condylar fracture with penetration of the condyle in the medium cranial fossa. (16297701)
2005
25
Temporomandibular joint ankylosis. A possible complication in juvenile psoriatic rheumatism. (16607767)
2005
26
Facilitated blind nasotracheal intubation in paralysed patients with temporomandibular joint ankylosis. (15670514)
2005
27
Management of temporo-mandibular joint ankylosis in growing children. (15858305)
2005
28
Cephalometric craniofacial characteristics in patients with temporomandibular joint ankylosis. (16231529)
2005
29
Treatment of post-stroke ankylosis by warm-needling. (15688698)
2004
30
The role of simultaneous gap arthroplasty and distraction osteogenesis in the management of temporo-mandibular joint ankylosis with mandibular deformity in children. (14729049)
2004
31
Operative release of complete ankylosis of the elbow due to heterotopic bone in patients without severe injury of the central nervous system. (12728035)
2003
32
Osteogenic distraction and orthognathic surgery to correct sequelae of ankylosis of the temporomandibular joint: a case report. (12593001)
2002
33
Airway management of a child with temporomandibular joint ankylosis following otitis media. (11879227)
2002
34
Treatment of temporomandibular joint ankylosis: a case report. (11841743)
2001
35
Effect of partial immobilization on reconstruction of ankylosis of the temporomandibular joint with an autogenous costochondral graft:an experimental study in sheep. (11384116)
2001
36
Bilateral cricoarytenoid joint ankylosis in scleroderma. (11391267)
2001
37
A review of anaesthetic technique in 15 paediatric patients with temporomandibular joint ankylosis. (11240886)
2001
38
Unusual ankylosis of the jaw due to fibrodysplasia ossificans progressiva. (10560885)
1999
39
Functional restoration by gap arthroplasty in temporomandibular joint ankylosis: a report of 50 cases. (10052370)
1999
40
Malleus ankylosis: a clinical, audiometric, histologic, and surgical study of 123 cases. (10565714)
1999
41
Temporomandibular joint ankylosis: review of thirty-two cases. (10371317)
1999
42
Temporomandibular joint ankylosis: the Egyptian experience. (10325678)
1999
43
Effects of occlusal loading on ankylosis, bone, and cementum formation during bone morphogenetic protein-2-stimulated periodontal regeneration in vivo. (10534065)
1999
44
Soft and hard tissue correction of facial deformity associated with bilateral temporomandibular joint ankylosis. (9869279)
1998
45
Management of post-traumatic temporomandibular joint ankylosis in children: case report. (7498034)
1995
46
Surgical management of temporomandibular joint ankylosis in the pediatric population. (8460181)
1993
47
Ankylosis of the distal interphalangeal joint in a horse after septic arthritis and septic navicular bursitis. (1577652)
1992
48
Spondyloarthropathy in progressive ankylosis mice: ultrastructural features of the intervertebral disk. (1659102)
1991
49
Atypical nemaline myopathy with temporomandibular ankylosis. (7191540)
1980
50
Temporomandibular ankylosis. (14779228)
1950

Genetic Variations for Ankylosis

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Expression for genes affiliated with Ankylosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for genes affiliated with Ankylosis

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37NCBI BioSystems Database, 55SinoBiological, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Ankylosis

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB, 28IUPHAR
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Compounds related to Ankylosis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1methylmethacrylate4410.4DSPP, BMP2
2alizarin4410.4BMP2, SP7
3teriparatide44 1111.3PTH1R, TNFRSF11B
4alendronate44 49 1112.3DSPP, BMP2, TNFRSF11B
5hydroxyapatite4410.2ANKH, DSPP, BMP2, TNFRSF11B
6polyglycolic acid4410.1BMP2, DSPP
7calcitriol44 59 11 2413.1TNFRSF11B, BMP2, DSPP, PTH1R
8azathioprine44 49 2 1113.1NOG, BMP2, TNFRSF11B
9vitamin d4410.0PTH1R, DSPP, BMP2, TNFRSF11B
10ascorbic acid44 2410.9TNFRSF11B, BMP2, DSPP, SETD2, SP7
111,25 dihydroxy vitamin d3449.9PTH1R, BMP2, TNFRSF11B
12tgf beta1449.9SETD2, BMP2, TNFRSF11B
13pyrophosphate44 2410.9TNFRSF11B, GUK1, ANKH, MARS2
14dexamethasone44 49 28 1112.8TNFRSF11B, BMP2, DSPP, NOG, PTH1R, SP7
15vegf449.7TNFRSF11B, BMP2, NOG, ERAP1, SETD2, SP7
16dihydrotestosterone44 28 11 2412.6SETD2, BMP2, TNFRSF11B
17serine449.5TNFRSF11B, BMP2, GUK1, TAF1, SLC20A2, NOG
18calcium44 49 11 2412.2TNFRSF11B, BMP2, GUK1, DSPP, ANKH, NOG

GO Terms for genes affiliated with Ankylosis

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16Gene Ontology
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Biological processes related to Ankylosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1osteoblast differentiationGO:00164910.2SP7, NOG, BMP2
2pericardium developmentGO:06003910.2SETD2, BMP2
3growthGO:04000710.1BMP2, GDF5, GDF7
4BMP signaling pathwayGO:03050910.1NOG, GDF7, BMP2
5cartilage developmentGO:05121610.1GDF5, DLX2, NOG
6pathway-restricted SMAD protein phosphorylationGO:06038910.0BMP2, GDF7
7cellular response to BMP stimulusGO:0717739.9NOG, BMP2
8skeletal system developmentGO:0015019.8PTH1R, NOG, ANKH, DSPP, BMP2, TNFRSF11B
9extracellular matrix organizationGO:0301989.8GDF5, TRAPPC4, BMP2, TNFRSF11B
10positive regulation of transcription from RNA polymerase II promoterGO:0459449.6SP7, NOG, TAF1, DLX2, BMP2

Molecular functions related to Ankylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inorganic phosphate transmembrane transporter activityGO:0053159.9SLC20A2, ANKH
2cytokine activityGO:0051259.8GDF7, GDF5, BMP2, TNFRSF11B

Products for genes affiliated with Ankylosis

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Sources for Ankylosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet