MCID: ANK001
MIFTS: 57

Ankylosis malady

Bone diseases category

Summaries for Ankylosis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. the rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards: Ankylosis is related to arthropathy and arthritis. An important gene associated with Ankylosis is ANKH (ANKH inorganic pyrophosphate transport regulator), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Basal cell carcinoma. The compounds methylmethacrylate and echinomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Wikipedia:66 Ankylosis or anchylosis (from Greek ???????, bent, crooked) is a stiffness of a joint due to abnormal... more...

Aliases & Classifications for Ankylosis

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9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

ankylosis 9 11 63


External Ids:

Disease Ontology9 DOID:227
MeSH36 D000844
ICD9CM28 718.50, 718.5

Related Diseases for Ankylosis

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18GeneCards, 19GeneDecks
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Diseases related to Ankylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 506)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy30.7BMP2, ANKH, TNFRSF11B
2arthritis30.6GDF5, TNFRSF11B, TGFB1, ANKH, BMP2
3fibrodysplasia ossificans progressiva30.3NOG, BMP2
4otosclerosis29.9NOG, TGFB1, TNFRSF11B
5multiple synostosis syndrome 129.8NOG
6progressive osseous heteroplasia29.7BMP2, NOG, ENPP1
7root resorption29.7BMP2, HEBP1, TNFRSF11B, GDF5
8osteoarthritis29.5GDF5, TNFRSF11B, TGFB1, DSPP, ANKH, BMP2
9temporomandibular ankylosis10.5
10tooth ankylosis10.4
11ankylosing spondylitis10.4
12spondylitis10.4
13rheumatoid arthritis10.2
14stapes ankylosis with broad thumb and toes10.2
15spondyloarthropathy10.1
16auriculocondylar syndrome 110.1GNAI3
17spondylolisthesis10.1BMP2
18degenerative disc disease10.1BMP2
19septic arthritis10.1
20congenital temporomandibular joint ankylosis10.1
21rickets10.1DSPP, HEBP1
22dental enamel hypoplasia10.1HEBP1, DSPP
23brachydactyly type a210.1GDF5, BMP2
24pseudogout10.1ANKH, ENPP1
25brachydactyly10.1NOG, GDF5
26x-linked hypophosphatemia10.1DSPP, ENPP1
27hypophosphatasia10.1DSPP, ENPP1
28osteosclerosis10.1TNFRSF11B, BMP2
29gingivitis10.1DSPP, TNFRSF11B
30arthrogryposis, distal, type 5d10.1ENPP1, SLC20A2
31gingival overgrowth10.1TGFB1, DSPP
32calcinosis10.1ENPP1, ANKH
33aortic valve stenosis10.1TNFRSF11B, BMP2
34osteogenesis imperfecta10.1DSPP, SP7
35multiple epiphyseal dysplasia10.1
36laryngitis10.1
37cardiocranial syndrome10.1
38polyarticular onset juvenile idiopathic arthritis10.1
39mucopolysaccharidosis ih10.1
40adenoameloblastoma10.1DSPP, TNFRSF11B
41hyperphosphatemia10.1TNFRSF11B, BMP2
42retinal ischemia10.0HIF1A, SETD2
43erythrocytosis10.0HIF1A, SETD2
44craniosynostosis10.0ANKH, BMP2, NOG, ENPP1
45factor v leiden thrombophilia10.0SETD2, DSPP, BMP2
46primary pulmonary hypertension10.0BMP2, SETD2, HIF1A
47non-small cell lung carcinoma10.0BMP2, SETD2, HIF1A
48diabetic nephropathy10.0TGFB1, BMP2, ENPP1
49noma10.0
50psoriatic arthritis10.0

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to ankylosis

Symptoms for Ankylosis

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Drugs & Therapeutics for Ankylosis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ankylosis

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Anatomical Context for Ankylosis

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34MalaCards
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MalaCards organs/tissues related to Ankylosis:

34
Bone, Skin, Brain, Spleen, T cells, Tonsil

Animal Models for Ankylosis or affiliated genes

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38MGI
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Publications for Ankylosis

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53PubMed
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Articles related to Ankylosis:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Congenital cheek teratoma with temporo-mandibular joint ankylosis managed with ultra-thin silicone sheet interpositional arthroplasty. (24163567)
2013
2
Axial involvement with facet joint arthropathy and bony ankylosis in a case of camptodactyly, arthropathy, coxa vara, pericarditis (CACP) syndrome. (23931850)
2013
3
Management of recurrent ankylosis in arthrogryposis: new solutions to a rare problem. (22652440)
2013
4
The role of three-dimensional computed tomography in the evaluation of temporomandibular joint ankylosis. (23066255)
2012
5
Selecting reconstruction option for TMJ ankylosis: a surgeon's dilemma. (23147341)
2012
6
Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo. (22121131)
2012
7
Two-stage total prosthetic reconstruction of temporomandibular joint in severe and recurrent ankylosis. (22976729)
2012
8
Overgrowth of costochondral graft in temporomandibular joint ankylosis: An unusual case. (22639507)
2011
9
Subankylotic ostectomy for release of TMJ ankylosis using the transmasseteric anterior parotid approach. (22134263)
2011
10
Ankylosis of permanent first molars: genetics or environment? A case report of a discordant twin pair. (21288789)
2011
11
Versatility of full thickness skin-subcutaneous fat grafts as interpositional material in the management of temporomandibular joint ankylosis. (20952163)
2011
12
Growth factors, genes, bone proteins and apoptosis in the temporomandibular joint (TMJ) of children with ankylosis and during disease recurrence. (22071418)
2011
13
Intramuscular injection of botulinum toxin as an adjunct to total joint replacement in temporomandibular joint ankylosis: preliminary reports. (21055863)
2011
14
Bifid mandibular condyle with ankylosis in a 3-year-old child: A rare presentation and review. (22114377)
2010
15
A new hypothesis of mechanisms of traumatic ankylosis of temporomandibular joint. (19261390)
2009
16
Long term results of cementless total hip replacement for reversal of hip ankylosis. (19462368)
2009
17
Infliximab in severe active ankylosing spondylitis with spinal ankylosis. (18336538)
2008
18
Minimum 1-year follow-up for patients with vertical shear sacroiliac joint dislocations treated with iliosacral screws: does joint ankylosis or anatomic reduction contribute to functional outcome? (18448980)
2008
19
Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandibular ankylosis in children. (18420320)
2008
20
Development of temporomandibular joint ankylosis in rats: a preliminary experimental study. (18178382)
2008
21
Temporo mandibular joint ankylosis. (18392499)
2008
22
Two-stage treatment of TMJ ankylosis by early surgical approach and distraction osteogenesis. (17251865)
2007
23
Video assisted fiberoptic intubation for temporomandibular ankylosis. (16618303)
2006
24
Report of ankylosis of the temporomandibular joint: treatment with a temporalis muscle flap and augmentation genioplasty. (16491155)
2006
25
Ankylosis due to heterotopic ossification following primary total knee arthroplasty. (17009834)
2006
26
Aesthetic veneer restoration of an anterior dentition postorthodontics complicated by ankylosis. (16358806)
2005
27
Formation and resolution of ankylosis under application of recombinant human bone morphogenetic protein-2 (rhBMP-2) to class III furcation defects in cats. (15966907)
2005
28
Ankylosis of traumatized permanent incisors: pathogenesis and current approaches to diagnosis and management. (16324230)
2005
29
The interpositional dermis-fat graft in the management of temporomandibular joint ankylosis. (15556322)
2004
30
Treatment of post-stroke ankylosis by warm-needling. (15688698)
2004
31
Treatment of temporomandibular joint ankylosis by a modified fossa prosthesis. (15262255)
2004
32
Facilitated ankylosis of the distal interphalangeal joint in a foal. (15181928)
2004
33
Stiffness and ankylosis in primary total knee arthroplasty. (14646741)
2003
34
Navigation-guided resection of temporomandibular joint ankylosis promotes safety in skull base surgery. (12420260)
2002
35
Total knee arthroplasty after spontaneous osseous ankylosis and takedown of formal knee fusion. (10884205)
2000
36
Unusual ankylosis of the jaw due to fibrodysplasia ossificans progressiva. (10560885)
1999
37
Ankylosing spondylitis: time to focus on ankylosis. (10229392)
1999
38
Zygomatico-coronoid ankylosis: a case report. (10416891)
1999
39
Arthroscopic laser debridement of temporomandibular joint fibrous and bony ankylosis: case report. (9734776)
1998
40
Sloppy hinge prosthetic elbow replacement for post-traumatic ankylosis or instability. (9699822)
1998
41
The autosomal dominant syndrome with congenital stapes ankylosis, broad thumbs and hyperopia. (9220188)
1997
42
Management of post-traumatic temporomandibular joint ankylosis in children: case report. (7498034)
1995
43
Pagetic vertebral ankylosis and diffuse idiopathic skeletal hyperostosis. (7747229)
1995
44
Treatment of elbow ankylosis by means of transplantation of the entire joint. Preliminary communication. 1908. (8194253)
1994
45
Phosphocitrate prevents disease progression in murine progressive ankylosis. (8240437)
1993
46
Myositis ossificans of medial pterygoid muscle. A cause for temporomandibular joint ankylosis. (1603562)
1992
47
Progressive ankylosis (ank/ank) in mice: an animal model of spondyloarthropathy. III. Proliferative spleen cell response to T cell mitogens. (2805429)
1989
48
Simultaneous total correction of temporomandibular ankylosis and facial asymmetry. (3513227)
1986
49
Surgical release of bilateral, intractable, temporomandibular ankylosis. (472055)
1979
50
Temporomandibular ankylosis secondary to rheumatoid arthritis. Report of a case. (1059058)
1975

Variations for Ankylosis

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Expression for genes affiliated with Ankylosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for genes affiliated with Ankylosis

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51PathCards, 52PharmGKB, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 58SinoBiological, 54QIAGEN
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Pathways related to Ankylosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLCB4, GNAI3
2
Show member pathways
9.5GNAI3, BMP2, PLCB4
3
Show member pathways
9.5BMP2, TGFB1, GDF5
49.4BMP2, TGFB1, HIF1A
5
Show member pathways
9.3BMP2, DSPP, TGFB1, GDF5
69.3GDF5, TGFB1, BMP2, NOG
7
Show member pathways
9.3GNAI3, TGFB1, BMP2, NOG
89.0GDF5, GDF7, TGFB1, BMP2
9
Show member pathways
8.9GDF5, GNAI3, HIF1A, TGFB1, BMP2
10
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
11
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
12
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
13
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
14
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
15
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
16
Show member pathways
8.8NOG, BMP2, TGFB1, GDF7, GDF5
17
Show member pathways
8.5GDF5, GNAI3, TNFRSF11B, TGFB1, BMP2, PLCB4
18
Show member pathways
8.5GDF5, GNAI3, HIF1A, TGFB1, BMP2, PLCB4
19
Show member pathways
7.7GNAI3, HIF1A, TGFB1, HEBP1, BMP2, PLCB4

Compounds for genes affiliated with Ankylosis

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Ankylosis according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1methylmethacrylate4610.3DSPP, BMP2
2echinomycin4610.2HIF1A, SETD2
33-(5-hydroxymethyl-2-furyl)-1-benzylindazole4610.2SETD2, HIF1A
4alizarin red s4610.2TGFB1, BMP2
5deferoxamine mesylate4610.1SETD2, HIF1A
6alendronate46 52 1212.1TNFRSF11B, DSPP, BMP2
7alizarin4610.1BMP2, SP7
8pimonidazole4610.0SETD2, HIF1A
9cocl24610.0SETD2, HIF1A
10halothane46 52 30 1212.9HIF1A, SETD2, DSPP
11pmma469.9DSPP, TGFB1, TNFRSF11B
12nitroglycerin46 1210.9SETD2, HIF1A, TNFRSF11B
13bortezomib46 52 1211.8TNFRSF11B, HIF1A, SETD2
14tetracycline46 1210.8BMP2, DSPP, TGFB1
15procollagen469.7TNFRSF11B, TGFB1, BMP2
16ns 39846 6210.7TNFRSF11B, HIF1A, TGFB1
17diphenyleneiodonium469.7HIF1A, TGFB1, SETD2
18heparan sulfate46 2510.7NOG, PLCB4, BMP2, TNFRSF11B
19neomycin469.7PLCB4, BMP2, TGFB1
20pdtc469.6HIF1A, TGFB1, SETD2
21calcitriol46 62 25 1212.6TNFRSF11B, TGFB1, DSPP, BMP2
22hydroxyapatite469.6TNFRSF11B, DSPP, ANKH, BMP2, ENPP1
23azathioprine46 3 52 1212.6NOG, BMP2, TNFRSF11B
24tgf beta1469.6BMP2, SETD2, TGFB1, TNFRSF11B
25vitamin d469.5BMP2, DSPP, TGFB1, TNFRSF11B
26rapamycin469.4HIF1A, SETD2, BMP2, ENPP1
27pyrophosphate46 2510.3GUK1, TNFRSF11B, ANKH, ENPP1
28lactate469.3HIF1A, TGFB1, SETD2, DSPP, BMP2
29genistein46 30 62 3 25 1214.2TNFRSF11B, HIF1A, SETD2, BMP2, PLCB4
30ascorbic acid46 2510.2SP7, TNFRSF11B, HIF1A, SETD2, DSPP, BMP2
31dihydrotestosterone46 30 25 1212.2TNFRSF11B, HIF1A, TGFB1, SETD2, BMP2
32sb 20358046 6210.2TNFRSF11B, HIF1A, TGFB1, SETD2, BMP2
33pge2469.2TNFRSF11B, HIF1A, TGFB1, SETD2, BMP2
34ly294002469.1TNFRSF11B, HIF1A, TGFB1, SETD2
35pd 98,059469.1HIF1A, TGFB1, SETD2, BMP2, PLCB4
36doxorubicin46 52 1211.0TNFRSF11B, HIF1A, TGFB1, SETD2
37cycloheximide469.0TNFRSF11B, HIF1A, TGFB1, SETD2, BMP2, NOG
38arginine469.0SLC20A2, PLCB4, BMP2, DSPP, HIF1A
39estrogen468.9TNFRSF11B, HIF1A, TGFB1, SETD2, DSPP, BMP2
40threonine468.9GDF5, HIF1A, TGFB1, SETD2, BMP2, ENPP1
41retinoic acid46 259.9TNFRSF11B, HIF1A, TGFB1, SETD2, BMP2, NOG
42cysteine468.9GDF5, TNFRSF11B, HIF1A, DSPP, BMP2, PLCB4
43actinomycin d468.8HIF1A, TGFB1, SETD2, BMP2
44vegf468.8SP7, TNFRSF11B, HIF1A, TGFB1, SETD2, BMP2
45atp46 309.5GUK1, TNFRSF11B, HIF1A, SETD2, PLCB4, ENPP1
46lipid468.5GUK1, TNFRSF11B, SETD2, BMP2, PLCB4, ENPP1
47dexamethasone46 52 30 1211.1ENPP1, SP7, TNFRSF11B, HIF1A, TGFB1, DSPP
48tyrosine467.9GDF5, GUK1, TNFRSF11B, HIF1A, SETD2, BMP2
49calcium46 52 25 1210.9SP7, GUK1, TNFRSF11B, SETD2, DSPP, ANKH
50serine467.2GUK1, TNFRSF11B, HIF1A, TGFB1, SETD2, DSPP

GO Terms for genes affiliated with Ankylosis

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17Gene Ontology
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Cellular components related to Ankylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.5DSPP, TGFB1, TNFRSF11B
2extracellular spaceGO:0056158.0ENPP1, GDF5, GDF7, TNFRSF11B, TGFB1, BMP2
3extracellular regionGO:0055767.6GDF5, TNFRSF11B, TGFB1, HEBP1, DSPP, BMP2

Biological processes related to Ankylosis according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1inorganic diphosphate transportGO:03050510.3ANKH, ENPP1
2cellular response to BMP stimulusGO:07177310.2BMP2, NOG
3pericardium developmentGO:06003910.2BMP2, SETD2
4regulation of bone mineralizationGO:03050010.2ANKH, ENPP1
5negative regulation of mesenchymal cell apoptotic processGO:200105410.2GDF5, HIF1A
6osteoblast differentiationGO:00164910.1NOG, BMP2, SP7
7positive regulation of odontogenesisGO:04248210.1TGFB1, BMP2
8biomineral tissue developmentGO:03121410.1ENPP1, DSPP
9positive regulation of branching involved in ureteric bud morphogenesisGO:09019010.1TGFB1, NOG
10connective tissue replacement involved in inflammatory response wound healingGO:00224810.0HIF1A, TGFB1
11negative regulation of ossificationGO:03027910.0ENPP1, TGFB1
12phosphate-containing compound metabolic processGO:0067969.9TGFB1, ENPP1
13chondrocyte differentiationGO:0020629.9BMP2, TGFB1, GDF5
14positive regulation vascular endothelial growth factor productionGO:0105759.8TGFB1, HIF1A
15positive regulation of epithelial to mesenchymal transitionGO:0107189.8BMP2, TGFB1
16growthGO:0400079.8GDF5, GDF7, BMP2
17BMP signaling pathwayGO:0305099.8GDF7, BMP2, NOG
18face morphogenesisGO:0603259.8NOG, TGFB1
19positive regulation of neuron differentiationGO:0456669.8GDF5, GDF7, BMP2
20skeletal system developmentGO:0015019.7TNFRSF11B, DSPP, ANKH, BMP2, NOG
21pathway-restricted SMAD protein phosphorylationGO:0603899.6GDF7, TGFB1, BMP2
22positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.6BMP2, TGFB1, GDF7
23cartilage developmentGO:0512169.6NOG, DLX2, HIF1A
24response to hypoxiaGO:0016669.6HIF1A, TGFB1, BMP2
25epithelial to mesenchymal transitionGO:0018379.6NOG, BMP2, TGFB1, HIF1A
26embryonic cranial skeleton morphogenesisGO:0487019.6SETD2, DLX2
27positive regulation of bone mineralizationGO:0305019.5BMP2, TGFB1
28extracellular matrix organizationGO:0301989.4GDF5, TNFRSF11B, TGFB1, DSPP, BMP2
29positive regulation of transcription, DNA-templatedGO:0458939.0GDF7, HIF1A, TGFB1, BMP2
30negative regulation of transcription from RNA polymerase II promoterGO:0001228.8NOG, DLX2, BMP2, TGFB1
31positive regulation of transcription from RNA polymerase II promoterGO:0459448.7SP7, HIF1A, TGFB1, BMP2, DLX2, NOG

Molecular functions related to Ankylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inorganic phosphate transmembrane transporter activityGO:00531510.0SLC20A2, ANKH
2growth factor activityGO:0080838.9BMP2, TGFB1, GDF7, GDF5
3cytokine activityGO:0051258.8GDF5, GDF7, TNFRSF11B, BMP2

Products for genes affiliated with Ankylosis

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Sources for Ankylosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet