Aliases & Classifications for Ankylosis

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Ankylosis, Aliases & Descriptions:

Name: Ankylosis 9 11 60


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Disease Ontology9 DOID:227
ICD9CM27 718.50, 718.5
MeSH33 D000844

Summaries for Ankylosis

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Disease Ontology:9 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. the rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary: Ankylosis is related to arthropathy and fibrodysplasia ossificans progressiva. An important gene associated with Ankylosis is ANKH (ANKH inorganic pyrophosphate transport regulator), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Basal cell carcinoma. The compounds methylmethacrylate and echinomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spleen, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Wikipedia:63 Ankylosis or anchylosis (from Greek ???????, bent, crooked) is a stiffness of a joint due to abnormal... more...

Related Diseases for Ankylosis

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Diseases related to Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 487)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy31.0BMP2, TNFRSF11B, ANKH
2fibrodysplasia ossificans progressiva30.8NOG, BMP2
3arthritis30.5ANKH, BMP2, GDF5, TNFRSF11B, TGFB1
4otosclerosis30.1TGFB1, TNFRSF11B, NOG
5osteogenesis imperfecta30.1DSPP, SP7
6osseous heteroplasia, progressive30.0BMP2, NOG, ENPP1
7root resorption29.8GDF5, TNFRSF11B, HEBP1, BMP2
8osteoarthritis29.0TNFRSF11B, TGFB1, DSPP, ANKH, BMP2, ENPP1
9temporomandibular ankylosis10.6
10auriculocondylar syndrome 110.5GNAI3
11spondylolisthesis10.5BMP2
12degenerative disc disease10.5BMP2
13rickets10.4HEBP1, DSPP
14tooth ankylosis10.4
15dental enamel hypoplasia10.4HEBP1, DSPP
16spondylitis10.4
17brachydactyly, type a210.4BMP2, GDF5
18chondrocalcinosis10.3ANKH, ENPP1
19brachydactyly10.3GDF5, NOG
20hypophosphatemic rickets, x-linked dominant10.3ENPP1, DSPP
21hypophosphatasia10.3ENPP1, DSPP
22stapes ankylosis with broad thumb and toes10.3
23hyperostosis, endosteal10.3TNFRSF11B, BMP2
24gingivitis10.3TNFRSF11B, DSPP
25arterial calcification of infancy10.3SLC20A2, ENPP1
26gingival overgrowth10.3DSPP, TGFB1
27calcinosis10.3ANKH, ENPP1
28aortic valve disease 210.3BMP2, TNFRSF11B
29ameloblastoma10.3DSPP, TNFRSF11B
30hyperphosphatemia10.2TNFRSF11B, BMP2
31rheumatoid arthritis10.2
32retinal ischemia10.2SETD2, HIF1A
33spondyloarthropathy10.2
34septic arthritis10.1
35cardiocranial syndrome10.1
36congenital temporomandibular joint ankylosis10.1
37factor v leiden thrombophilia10.1DSPP, BMP2, SETD2
38craniosynostosis10.1ENPP1, BMP2, ANKH, NOG
39mandibuloacral dysplasia10.1
40psoriatic arthritis10.1
41distal arthrogryposis10.1
42laryngitis10.1
43glossopalatine ankylosis micrognathia ear anomalies10.1
44polyarticular onset juvenile idiopathic arthritis10.1
45glossopalatine ankylosis10.1
46pulmonary hypertension10.1HIF1A, BMP2, SETD2
47lung cancer10.0HIF1A, SETD2, BMP2
48microvascular complications of diabetes 310.0ENPP1, BMP2, TGFB1
49symphalangism, proximal10.0
50mucopolysaccharidosis is10.0

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to ankylosis

Symptoms for Ankylosis

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Drugs & Therapeutics for Ankylosis

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Drug clinical trials:

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Search NIH Clinical Center for Ankylosis

Genetic Tests for Ankylosis

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Anatomical Context for Ankylosis

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MalaCards organs/tissues related to Ankylosis:

31
Bone, Skin, Spleen, Brain, Tonsil, T cells

Animal Models for Ankylosis or affiliated genes

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Publications for Ankylosis

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Articles related to Ankylosis:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Factors Influencing Treatment Plan and Post Operative Compliance in TMJ Ankylosis Patients: A Retrospective Analysis of Long Term Post Surgical Evaluation. (25729222)
2015
2
Identification of two novel mutations in the NOG gene associated with congenital stapes ankylosis and symphalangism. (25391606)
2014
3
Functional Outcomes of Gap and Interposition Arthroplasty in the Treatment of Temporomandibular Joint Ankylosis. (25315308)
2014
4
Ankylosis of Temporomandibular Joint caused by Psoriatic Arthritis: A Report of Four Cases with Literature Review. (25028690)
2014
5
Fat metaplasia and backfill are key intermediaries in the development of sacroiliac joint ankylosis in patients with ankylosing spondylitis. (25047851)
2014
6
Temperomandibular joint ankylosis in children. (25210367)
2014
7
Congenital cheek teratoma with temporo-mandibular joint ankylosis managed with ultra-thin silicone sheet interpositional arthroplasty. (24163567)
2013
8
Axial involvement with facet joint arthropathy and bony ankylosis in a case of camptodactyly, arthropathy, coxa vara, pericarditis (CACP) syndrome. (23931850)
2013
9
Management of recurrent ankylosis in arthrogryposis: new solutions to a rare problem. (22652440)
2013
10
The role of three-dimensional computed tomography in the evaluation of temporomandibular joint ankylosis. (23066255)
2012
11
Selecting reconstruction option for TMJ ankylosis: a surgeon's dilemma. (23147341)
2012
12
Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo. (22121131)
2012
13
Two-stage total prosthetic reconstruction of temporomandibular joint in severe and recurrent ankylosis. (22976729)
2012
14
Overgrowth of costochondral graft in temporomandibular joint ankylosis: An unusual case. (22639507)
2011
15
Subankylotic ostectomy for release of TMJ ankylosis using the transmasseteric anterior parotid approach. (22134263)
2011
16
Ankylosis of permanent first molars: genetics or environment? A case report of a discordant twin pair. (21288789)
2011
17
Versatility of full thickness skin-subcutaneous fat grafts as interpositional material in the management of temporomandibular joint ankylosis. (20952163)
2011
18
Bifid mandibular condyle with ankylosis in a 3-year-old child: A rare presentation and review. (22114377)
2010
19
A new hypothesis of mechanisms of traumatic ankylosis of temporomandibular joint. (19261390)
2009
20
Infliximab in severe active ankylosing spondylitis with spinal ankylosis. (18336538)
2008
21
Minimum 1-year follow-up for patients with vertical shear sacroiliac joint dislocations treated with iliosacral screws: does joint ankylosis or anatomic reduction contribute to functional outcome? (18448980)
2008
22
Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandibular ankylosis in children. (18420320)
2008
23
Development of temporomandibular joint ankylosis in rats: a preliminary experimental study. (18178382)
2008
24
Temporo mandibular joint ankylosis. (18392499)
2008
25
Two-stage treatment of TMJ ankylosis by early surgical approach and distraction osteogenesis. (17251865)
2007
26
Video assisted fiberoptic intubation for temporomandibular ankylosis. (16618303)
2006
27
Report of ankylosis of the temporomandibular joint: treatment with a temporalis muscle flap and augmentation genioplasty. (16491155)
2006
28
Ankylosis due to heterotopic ossification following primary total knee arthroplasty. (17009834)
2006
29
Aesthetic veneer restoration of an anterior dentition postorthodontics complicated by ankylosis. (16358806)
2005
30
Formation and resolution of ankylosis under application of recombinant human bone morphogenetic protein-2 (rhBMP-2) to class III furcation defects in cats. (15966907)
2005
31
Ankylosis of traumatized permanent incisors: pathogenesis and current approaches to diagnosis and management. (16324230)
2005
32
The interpositional dermis-fat graft in the management of temporomandibular joint ankylosis. (15556322)
2004
33
Treatment of post-stroke ankylosis by warm-needling. (15688698)
2004
34
Treatment of temporomandibular joint ankylosis by a modified fossa prosthesis. (15262255)
2004
35
Stiffness and ankylosis in primary total knee arthroplasty. (14646741)
2003
36
Navigation-guided resection of temporomandibular joint ankylosis promotes safety in skull base surgery. (12420260)
2002
37
Total knee arthroplasty after spontaneous osseous ankylosis and takedown of formal knee fusion. (10884205)
2000
38
Unusual ankylosis of the jaw due to fibrodysplasia ossificans progressiva. (10560885)
1999
39
Ankylosing spondylitis: time to focus on ankylosis. (10229392)
1999
40
Zygomatico-coronoid ankylosis: a case report. (10416891)
1999
41
Arthroscopic laser debridement of temporomandibular joint fibrous and bony ankylosis: case report. (9734776)
1998
42
Sloppy hinge prosthetic elbow replacement for post-traumatic ankylosis or instability. (9699822)
1998
43
Management of post-traumatic temporomandibular joint ankylosis in children: case report. (7498034)
1995
44
Pagetic vertebral ankylosis and diffuse idiopathic skeletal hyperostosis. (7747229)
1995
45
Treatment of elbow ankylosis by means of transplantation of the entire joint. Preliminary communication. 1908. (8194253)
1994
46
Phosphocitrate prevents disease progression in murine progressive ankylosis. (8240437)
1993
47
Myositis ossificans of medial pterygoid muscle. A cause for temporomandibular joint ankylosis. (1603562)
1992
48
Progressive ankylosis (ank/ank) in mice: an animal model of spondyloarthropathy. III. Proliferative spleen cell response to T cell mitogens. (2805429)
1989
49
Simultaneous total correction of temporomandibular ankylosis and facial asymmetry. (3513227)
1986
50
Surgical release of bilateral, intractable, temporomandibular ankylosis. (472055)
1979

Variations for Ankylosis

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Expression for genes affiliated with Ankylosis

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Search GEO for disease gene expression data for Ankylosis.

Pathways for genes affiliated with Ankylosis

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Pathways related to Ankylosis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLCB4, GNAI3
2
Show member pathways
9.5GNAI3, PLCB4, BMP2
3
Show member pathways
9.5GDF5, TGFB1, BMP2
49.4TGFB1, HIF1A, BMP2
5
Show member pathways
9.3GDF5, TGFB1, BMP2, DSPP
69.3BMP2, NOG, TGFB1, GDF5
7
Show member pathways
9.3GNAI3, TGFB1, BMP2, NOG
89.0BMP2, GDF7, TGFB1, GDF5
9
Show member pathways
8.9BMP2, TGFB1, GDF5, HIF1A, GNAI3
10
Show member pathways
8.8PLCB4, BMP2, GDF5, GNAI3, TGFB1
11
Show member pathways
8.8PLCB4, BMP2, TGFB1, GNAI3, GDF5
12
Show member pathways
8.8GDF5, TGFB1, BMP2, PLCB4, GNAI3
13
Show member pathways
8.8BMP2, TGFB1, GNAI3, PLCB4, GDF5
14
Show member pathways
8.8GNAI3, TGFB1, BMP2, PLCB4, GDF5
15
Show member pathways
8.8GDF5, PLCB4, GNAI3, TGFB1, BMP2
16
Show member pathways
8.8GDF7, TGFB1, BMP2, NOG, GDF5
17
Show member pathways
8.5TNFRSF11B, TGFB1, BMP2, PLCB4, GNAI3, GDF5
18
Show member pathways
8.5GDF5, BMP2, PLCB4, TGFB1, HIF1A, GNAI3
19
Show member pathways
7.7HEBP1, HIF1A, PLCB4, GNAI3, NOG, BMP2

Compounds for genes affiliated with Ankylosis

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Compounds related to Ankylosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1methylmethacrylate4310.3BMP2, DSPP
2echinomycin4310.2SETD2, HIF1A
33-(5-hydroxymethyl-2-furyl)-1-benzylindazole4310.2HIF1A, SETD2
4alizarin red s4310.2TGFB1, BMP2
5deferoxamine mesylate4310.1HIF1A, SETD2
6alendronate43 49 1212.1TNFRSF11B, DSPP, BMP2
7alizarin4310.1SP7, BMP2
8pimonidazole4310.0HIF1A, SETD2
9cocl24310.0SETD2, HIF1A
10halothane43 49 28 1212.9HIF1A, SETD2, DSPP
11pmma439.9TNFRSF11B, TGFB1, DSPP
12nitroglycerin43 1210.9TNFRSF11B, HIF1A, SETD2
13bortezomib43 49 1211.8SETD2, HIF1A, TNFRSF11B
14tetracycline43 1210.8TGFB1, BMP2, DSPP
15procollagen439.7BMP2, TGFB1, TNFRSF11B
16ns 39843 5910.7TNFRSF11B, TGFB1, HIF1A
17diphenyleneiodonium439.7SETD2, TGFB1, HIF1A
18heparan sulfate43 2410.7PLCB4, BMP2, TNFRSF11B, NOG
19neomycin439.7PLCB4, TGFB1, BMP2
20pdtc439.6SETD2, TGFB1, HIF1A
21calcitriol43 59 24 1212.6TGFB1, BMP2, DSPP, TNFRSF11B
22hydroxyapatite439.6ANKH, DSPP, ENPP1, TNFRSF11B, BMP2
23azathioprine43 2 49 1212.6TNFRSF11B, NOG, BMP2
24tgf beta1439.6TGFB1, SETD2, BMP2, TNFRSF11B
25vitamin d439.5BMP2, TNFRSF11B, TGFB1, DSPP
26rapamycin439.4ENPP1, HIF1A, SETD2, BMP2
27pyrophosphate43 2410.3ANKH, GUK1, ENPP1, TNFRSF11B
28lactate439.3TGFB1, SETD2, DSPP, BMP2, HIF1A
29genistein43 28 59 2 24 1214.2TNFRSF11B, HIF1A, SETD2, BMP2, PLCB4
30ascorbic acid43 2410.2TNFRSF11B, SP7, HIF1A, SETD2, BMP2, DSPP
31dihydrotestosterone43 28 24 1212.2BMP2, HIF1A, TNFRSF11B, SETD2, TGFB1
32sb 20358043 5910.2TGFB1, SETD2, BMP2, HIF1A, TNFRSF11B
33pge2439.2HIF1A, SETD2, TNFRSF11B, BMP2, TGFB1
34ly294002439.1SETD2, TNFRSF11B, HIF1A, TGFB1
35pd 98,059439.1TGFB1, SETD2, BMP2, PLCB4, HIF1A
36doxorubicin43 49 1211.0TNFRSF11B, HIF1A, TGFB1, SETD2
37cycloheximide439.0TNFRSF11B, NOG, BMP2, SETD2, TGFB1, HIF1A
38arginine439.0SLC20A2, BMP2, DSPP, HIF1A, PLCB4
39estrogen438.9TNFRSF11B, HIF1A, TGFB1, SETD2, BMP2, DSPP
40threonine438.9TGFB1, SETD2, HIF1A, GDF5, ENPP1, BMP2
41retinoic acid43 249.9SETD2, HIF1A, BMP2, NOG, TGFB1, TNFRSF11B
42cysteine438.9HIF1A, GDF5, PLCB4, DSPP, BMP2, NOG
43actinomycin d438.8HIF1A, TGFB1, BMP2, SETD2
44vegf438.8NOG, TNFRSF11B, SP7, HIF1A, BMP2, SETD2
45atp43 289.5GUK1, HIF1A, SETD2, PLCB4, ENPP1, TNFRSF11B
46lipid438.5TNFRSF11B, ENPP1, SETD2, PLCB4, BMP2, GUK1
47dexamethasone43 49 28 1211.1DSPP, NOG, PLCB4, BMP2, ENPP1, TGFB1
48tyrosine437.9GDF5, GUK1, TNFRSF11B, HIF1A, ENPP1, PLCB4
49calcium43 49 24 1210.9BMP2, NOG, ANKH, SP7, DSPP, GUK1
50serine437.2SLC20A2, GUK1, TNFRSF11B, ENPP1, NOG, PLCB4

GO Terms for genes affiliated with Ankylosis

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Cellular components related to Ankylosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.5DSPP, TNFRSF11B, TGFB1
2extracellular spaceGO:00056158.0GDF5, GDF7, TNFRSF11B, TGFB1, BMP2, NOG
3extracellular regionGO:00055767.6NOG, GDF5, TNFRSF11B, TGFB1, HEBP1, DSPP

Biological processes related to Ankylosis according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1inorganic diphosphate transportGO:003050510.3ANKH, ENPP1
2cellular response to BMP stimulusGO:007177310.2BMP2, NOG
3pericardium developmentGO:006003910.2BMP2, SETD2
4regulation of bone mineralizationGO:003050010.2ANKH, ENPP1
5negative regulation of mesenchymal cell apoptotic processGO:0200105410.2GDF5, HIF1A
6osteoblast differentiationGO:000164910.1NOG, BMP2, SP7
7positive regulation of odontogenesisGO:004248210.1TGFB1, BMP2
8biomineral tissue developmentGO:003121410.1ENPP1, DSPP
9positive regulation of branching involved in ureteric bud morphogenesisGO:009019010.1TGFB1, NOG
10connective tissue replacement involved in inflammatory response wound healingGO:000224810.0HIF1A, TGFB1
11negative regulation of ossificationGO:003027910.0ENPP1, TGFB1
12phosphate-containing compound metabolic processGO:00067969.9TGFB1, ENPP1
13chondrocyte differentiationGO:00020629.9BMP2, TGFB1, GDF5
14positive regulation vascular endothelial growth factor productionGO:00105759.8TGFB1, HIF1A
15positive regulation of epithelial to mesenchymal transitionGO:00107189.8BMP2, TGFB1
16growthGO:00400079.8GDF5, GDF7, BMP2
17BMP signaling pathwayGO:00305099.8GDF7, BMP2, NOG
18face morphogenesisGO:00603259.8NOG, TGFB1
19positive regulation of neuron differentiationGO:00456669.8GDF5, GDF7, BMP2
20skeletal system developmentGO:00015019.7TNFRSF11B, DSPP, ANKH, BMP2, NOG
21pathway-restricted SMAD protein phosphorylationGO:00603899.6GDF7, TGFB1, BMP2
22positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.6BMP2, TGFB1, GDF7
23cartilage developmentGO:00512169.6NOG, DLX2, HIF1A
24response to hypoxiaGO:00016669.6HIF1A, TGFB1, BMP2
25epithelial to mesenchymal transitionGO:00018379.6NOG, BMP2, TGFB1, HIF1A
26embryonic cranial skeleton morphogenesisGO:00487019.6SETD2, DLX2
27positive regulation of bone mineralizationGO:00305019.5BMP2, TGFB1
28extracellular matrix organizationGO:00301989.4GDF5, TNFRSF11B, TGFB1, DSPP, BMP2
29positive regulation of transcription, DNA-templatedGO:00458939.0GDF7, HIF1A, TGFB1, BMP2
30negative regulation of transcription from RNA polymerase II promoterGO:00001228.8NOG, DLX2, BMP2, TGFB1
31positive regulation of transcription from RNA polymerase II promoterGO:00459448.7SP7, HIF1A, TGFB1, BMP2, DLX2, NOG

Molecular functions related to Ankylosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inorganic phosphate transmembrane transporter activityGO:000531510.0SLC20A2, ANKH
2growth factor activityGO:00080838.9BMP2, TGFB1, GDF7, GDF5
3cytokine activityGO:00051258.8GDF5, GDF7, TNFRSF11B, BMP2

Products for genes affiliated with Ankylosis

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