Aliases & Classifications for Ankylosis

MalaCards integrated aliases for Ankylosis:

Name: Ankylosis 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:227
ICD10 33 M24.6
ICD9CM 35 718.5 718.50
MeSH 42 D000844
UMLS 69 C0003090

Summaries for Ankylosis

Disease Ontology : 12 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary : Ankylosis is related to auriculocondylar syndrome 1 and fibrodysplasia ossificans progressiva, and has symptoms including arthralgia, metatarsalgia and joint stiffness. An important gene associated with Ankylosis is ANKH (ANKH Inorganic Pyrophosphate Transport Regulator), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Pamidronate and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and endothelial, and related phenotypes are Decreased IL-13 protein expression and cardiovascular system

Wikipedia : 72 Ankylosis or anchylosis (from Greek ἀγκύλος, bent, crooked) is a stiffness of a joint due to abnormal... more...

Related Diseases for Ankylosis

Diseases related to Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 auriculocondylar syndrome 1 31.6 GNAI3 PLCB4
2 fibrodysplasia ossificans progressiva 31.6 ACVR1 BMP4 NOG
3 tooth ankylosis 12.4
4 temporomandibular ankylosis 12.2
5 stapes ankylosis with broad thumb and toes 12.2
6 congenital temporomandibular joint ankylosis 11.9
7 glossopalatine ankylosis 11.8
8 craniostenosis, sagittal, with congenital heart disease, mental deficiency, and mandibular ankylosis 11.8
9 glossopalatine ankylosis micrognathia ear anomalies 11.7
10 arthropathy 11.7
11 cardiocranial syndrome 11.3
12 diffuse idiopathic skeletal hyperostosis 11.0
13 craniometaphyseal dysplasia 11.0
14 deafness, progressive, with stapes fixation 10.9
15 pfeiffer syndrome 10.8
16 restrictive dermopathy, lethal 10.8
17 auriculocondylar syndrome 2 10.8
18 piussan lenaerts mathieu syndrome 10.7
19 distal arthrogryposis 10.7
20 johnson hall krous syndrome 10.7
21 spondyloarthropathy 1 10.7
22 symphalangism, distal 10.7
23 symphalangism, proximal, 1a 10.7
24 charlie m syndrome 10.7
25 hypoglossia-hypodactylia 10.7
26 syngnathia 10.7
27 proximal symphalangism 10.7
28 auriculocondylar syndrome 3 10.7
29 multiple synostoses syndrome 10.7
30 autoimmune atrophic gastritis 10.5 GNAI3 PLCB4
31 zika fever 10.4 FGFR2 NOG
32 arthritis 10.2
33 spondylitis 10.2
34 rheumatoid arthritis 10.0
35 short qt syndrome 10.0 BMP2 BMP4 NOG
36 chondrocalcinosis 2 10.0 ACVR1 ANKH SP7
37 humeroradial synostosis 10.0 BMP2 BMP4
38 vaginal carcinosarcoma 9.9 BGLAP RUNX2
39 septic arthritis 9.9
40 spondyloarthropathy 9.9
41 cervicitis 9.9
42 psoriatic arthritis 9.8
43 laryngitis 9.8
44 myositis 9.8
45 hyperostosis 9.8
46 myositis ossificans 9.8
47 otitis media 9.8
48 periodontitis 9.8
49 noma 9.8
50 crohn's disease 9.7 BMP2 FGFR2 NOG RUNX2

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to Ankylosis

Symptoms & Phenotypes for Ankylosis

UMLS symptoms related to Ankylosis:


arthralgia, metatarsalgia, joint stiffness, joint symptom

GenomeRNAi Phenotypes related to Ankylosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased IL-13 protein expression GR00219-A 8.62 ACVR1 FGFR2

MGI Mouse Phenotypes related to Ankylosis:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ACVR1 ANKH BMP2 BMP4 FGFR2 GNAI3
2 cellular MP:0005384 10.16 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
3 growth/size/body region MP:0005378 10.16 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
4 craniofacial MP:0005382 10.1 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
5 limbs/digits/tail MP:0005371 10.02 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
6 hematopoietic system MP:0005397 10.01 ANKH BMP2 BMP4 FGFR2 GNAI3 IBSP
7 hearing/vestibular/ear MP:0005377 9.98 NOG TNFRSF11B ACVR1 ANKH BMP2 BMP4
8 immune system MP:0005387 9.97 ACVR1 ANKH BMP2 FGFR2 GNAI3 IBSP
9 mortality/aging MP:0010768 9.96 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
10 digestive/alimentary MP:0005381 9.95 NOG RUNX2 ACVR1 BMP2 BMP4 FGFR2
11 muscle MP:0005369 9.7 ACVR1 ANKH BMP4 FGFR2 NOG PLCB4
12 respiratory system MP:0005388 9.43 ANKH BMP4 FGFR2 NOG RUNX2 SP7
13 skeleton MP:0005390 9.4 NOG PLCB4 RUNX2 SP7 TNFRSF11B ACVR1

Drugs & Therapeutics for Ankylosis

Drugs for Ankylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 130)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pamidronate Approved Phase 4 40391-99-9 4674
2
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
3
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
4
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
5
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
6
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
7
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
8
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
9
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
10
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
11
Aceclofenac Approved Phase 4 89796-99-6
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
15
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
16 Analgesics Phase 4,Phase 2,Phase 3
17 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
18 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
20 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
25 Natriuretic Agents Phase 4
26 Natriuretic Peptide, Brain Phase 4
27 Antimetabolites Phase 4,Phase 3,Phase 2
28 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
29 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
30 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
31 Vitamin B Complex Phase 4,Phase 3,Phase 2
32 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
33 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
34 Anti-Infective Agents Phase 4,Phase 2,Phase 3
35 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
36 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
37 Vaccines Phase 4,Phase 2
38 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
39 Bone Density Conservation Agents Phase 4
40 Endothelial Growth Factors Phase 4
41 Mitogens Phase 4
42 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
43 Antibiotics, Antitubercular Phase 4
44 Anticholesteremic Agents Phase 4
45 Cholestyramine Resin Phase 4
46 Hypolipidemic Agents Phase 4
47 Lipid Regulating Agents Phase 4
48 Analgesics, Opioid Phase 4
49 Central Nervous System Depressants Phase 4,Phase 3
50 Narcotics Phase 4

Interventional clinical trials:

(show top 50) (show all 291)

id Name Status NCT ID Phase Drugs
1 Gait Analysis of Ankle Arthroplasty and Arthrodesis Unknown status NCT00921076 Phase 4
2 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
3 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
4 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
5 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
6 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
7 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
8 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
9 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
10 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4 Enbrel
11 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
12 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
13 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4 alendronate
14 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
15 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
16 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
17 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
18 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
19 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
20 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4 Infliximab; observational study;Methotrexate; observational study
21 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
22 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
23 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
24 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4 Etanercept
25 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
26 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
27 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
28 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
29 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
30 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
31 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
32 Study Investigating Enbrel Treatment for Ankylosing Spondylitis Completed NCT00195416 Phase 4 Etanercept
33 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
34 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
35 A Randomized, Double-blind, Placebo-controlled Multicenter Study of Secukinumab (AIN457) to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylit Recruiting NCT02763046 Phase 4 AIN457/Secukinumab Placebo
36 NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in Ankylosing Spondylitis Recruiting NCT02758782 Phase 4 Celecoxib
37 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Recruiting NCT02634541 Phase 4 Adalimumab
38 Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA Recruiting NCT02509026 Phase 4
39 Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients Recruiting NCT02492217 Phase 4 Adalimumab
40 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Active, not recruiting NCT02489760 Phase 4
41 Delaying Ossification and Improving Inflammation of Celebrex Plus/or Enbrel Treatment on Active Ankylosing Spondylitis Active, not recruiting NCT01934933 Phase 4 celebrex;Enbrel;Enbrel plus Celebrex
42 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Not yet recruiting NCT03190603 Phase 4 Celecoxib
43 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Not yet recruiting NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
44 Enthesitis With Ultra Sonography Doppler in Spondyloarthropathies Treated With Infliximab (Study P04440) Terminated NCT00686894 Phase 4 Infliximab
45 Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem Terminated NCT01422564 Phase 4
46 Effects of Etanercept on the Heart, Veins and Thickness of Certain Major Arteries In Ankylosing Spondylitis Patients Terminated NCT00910273 Phase 4 etanercept
47 An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs) Terminated NCT00766402 Phase 4 Tramadol /acetaminophen;Diclofenac
48 A Study to Assess the Safety and Effectiveness of Golimumab in Filipino Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Withdrawn NCT01692457 Phase 4 No intervention
49 Effectiveness and Safety of Early Treatment With Infliximab for Hip Arthritis Associated With Ankylosing Spondylitis (AS) (P06451) Withdrawn NCT01148901 Phase 4 Infliximab
50 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate

Search NIH Clinical Center for Ankylosis

Cochrane evidence based reviews: ankylosis

Genetic Tests for Ankylosis

Anatomical Context for Ankylosis

MalaCards organs/tissues related to Ankylosis:

39
Bone, Testes, Endothelial, T Cells, Heart, Skin, Brain

Publications for Ankylosis

Articles related to Ankylosis:

(show top 50) (show all 661)
id Title Authors Year
1
Temporomandibular Joint Ankylosis After Early Mandibular Distraction Osteogenesis: A New Syndrome? ( 28538064 )
2017
2
The role of the progressive ankylosis protein (ANK) in adipogenic/osteogenic fate decision of precursor cells. ( 28286238 )
2017
3
Neocondyle distraction osteogenesis in the management of temporomandibular joint ankylosis: Report of five cases with review of literature. ( 28721990 )
2017
4
Miniscrew-Supported Orthodontic Pseudo-Ankylosis for Mesialization of a Lower Third Molar. ( 28668944 )
2017
5
Re-Assessment of Coronoid as a Graft for Condylar Reconstruction in TMJ Ankylosis Patients: A Prospective Study and Literature Review. ( 28439157 )
2017
6
Application of Bidirectional Distraction Osteogenesis for the Treatment of Mandibular Micriognathia Caused by Temporomandibular Joint Ankylosis. ( 28692514 )
2017
7
Application of a computer-assisted surgical navigation system in temporomandibular joint ankylosis surgery: a retrospective study. ( 27839946 )
2017
8
Proximal interphalangeal joint ankylosis in an early medieval horse from WrocA8aw Cathedral Island, Poland. ( 28521909 )
2017
9
A preliminary study of effects of low-intensity pulsed ultrasound (LIPUS) irradiation on dentoalveolar ankylosis. ( 28904322 )
2017
10
Results and outcome predictors after open release of complete ankylosis of the elbow caused by heterotopic ossification. ( 28083670 )
2017
11
Overgrowth of costochondral graft in temporomandibular joint ankylosis reconstruction: A retrospective study. ( 28611327 )
2017
12
A Case of Glenoid Fossa Fracture, Progressive Ankylosis, Total Joint Reconstruction with Alloplastic Prosthesis to Normalized Function Including Evaluation with F18-PET/CT-a Four Year Follow-up. ( 28210410 )
2017
13
Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis. ( 28743287 )
2017
14
Prophylactic embolisation of the internal maxillary artery in patients with ankylosis of the temporomandibular joint. ( 28372882 )
2017
15
Ankylosis of the knee after septic arthritis following anterior cruciate ligament reconstruction in a 13-year-old male. ( 28342819 )
2017
16
Simultaneous Reconstruction of Both Facial Paralysis and Temporomandibular Joint Ankylosis With a Composite Flap From Dorsum of Foot. ( 28891897 )
2017
17
Ankylosis of temporomandibular joints after mandibular distraction osteogenesis in patients with Nager syndrome: Report of two cases and literature review. ( 28688869 )
2017
18
3-D computed tomography measurement of mandibular growth after costochondral grafting in growing children with temporomandibular joint ankylosis and jaw deformity. ( 28739355 )
2017
19
Ankylosis of the Finger in Erosive Osteoarthritis. ( 28090062 )
2017
20
Simultaneous treatment of temporomandibular joint ankylosis with severe mandibular deficiency by standard TMJ prosthesis. ( 28337986 )
2017
21
Cone-beam computed tomography evaluation of the maxillofacial features of patients with unilateral temporomandibular joint ankylosis undergoing condylar reconstruction with an autogenous coronoid process graft. ( 28257487 )
2017
22
Evaluation of the condyle remodeling after lateral arthroplasty in growing children with temporomandibular joint ankylosis. ( 28855535 )
2017
23
Ankylosis of the Temporomandibular Joint and Reconstruction With a Costochondral Graft in a Patient With Juvenile Idiopathic Arthritis. ( 27930467 )
2017
24
Stapediovestibular ankylosis in an HIV/HCV-copositive patient. ( 26991224 )
2016
25
Temporomandibular joint ankylosis contributing to coronoid process hyperplasia. ( 27173825 )
2016
26
An unusual anterior dislocation of fractured mandibular condyle leading to psuedo-ankylosis in a 8 yr old child-A distinct case report. ( 27448226 )
2016
27
Temporomandibular joint ankylosis as part of the clinical spectrum of Carey-Fineman-Ziter syndrome? ( 27232676 )
2016
28
The progressive ankylosis protein ANK facilitates clathrin- and adaptor-mediated membrane traffic at the trans-Golgi network-to-endosome interface. ( 27466194 )
2016
29
Silicone vs temporalis fascia interposition in TMJ ankylosis: A comparison. ( 27195207 )
2016
30
Re: Agarwal et al. Stylomandibular fusion that complicates recurrent bilateral ankylosis of the temporomandibular joint. ( 27131983 )
2016
31
Role of bilateral mandibular distraction for asymmetry due to unilateral ankylosis. ( 27707606 )
2016
32
Unilateral spontaneous ankylosis of the C1/C2 joint with "crowned dens syndrome": Computed tomography scan is imperative in diagnosis. ( 27695247 )
2016
33
Retrospective evaluation of airway management with blind awake intubation in temporomandibular joint ankylosis patients: A review of 48 cases. ( 27563608 )
2016
34
TMJ replacement utilizing patient-fitted TMJ TJR devices in a re-ankylosis child. ( 26920044 )
2016
35
Ankylosis and pseudoankylosis of the temporomandibular joint in 10 dogs (1993-2015). ( 27439984 )
2016
36
Supracondylar femoral osteotomy and knee joint replacement during the same surgical procedure in a type A haemophiliac patient with knee flexion deformity and ankylosis. ( 27919671 )
2016
37
Bony ankylosis of hydroxyapatite prostheses in the middle ear. ( 26954869 )
2016
38
Surgical correction without bone grafts of maxillofacial asymmetric deformities in patients treated for unilateral temporomandibular joint ankylosis. ( 27614813 )
2016
39
Case 229: Burn-related Global Ankylosis of Interphalangeal Joints with Associated Acroosteolysis. ( 27089192 )
2016
40
Temporomandibular Joint Ankylosis Can Be Successfully Treated With TMJ Concepts Patient-Fitted Total Joint Prosthesis and Autogenous Fat Grafts. ( 26878364 )
2016
41
Distraction osteogenesis in the treatment of temporomandibular joint ankylosis with mandibular micrognathia. ( 27563611 )
2016
42
Stylo-mandibular fusion complicating recurrent bilateral temporomandibular joint ankylosis. ( 26837637 )
2016
43
Minimally Invasive Treatment of Temporomandibular Joint Ankylosis and Fibrosis of Temporalis Muscle. ( 27348948 )
2016
44
Surgical Treatment of Neglected Traumatic Quadriceps Tendon Rupture with Knee Ankylosis. ( 27274474 )
2016
45
Temporomandibular joint ankylosis in ankylosing spondylitis: A case report and review of literature. ( 28217617 )
2016
46
Spontaneous Knee Ankylosis through Heterotopic Ossification after Total Knee Arthroplasty. ( 27119034 )
2016
47
Single-stage temporomandibular joint arthroplasty in a patient with complete bony ankylosis and previous extradural haematoma. ( 28049115 )
2016
48
A comparative study of different surgical methods in the treatment of traumatic temporomandibular joint ankylosis. ( 27658755 )
2016
49
One stage treatment of temporomandibular joint complete bony ankylosis using total joint replacement. ( 26897300 )
2016
50
Total Alloplastic Joint Reconstruction in a Patient With Temporomandibular Joint Ankylosis Following Condylar Dislocation Into the Middle Cranial Fossa. ( 27566458 )
2016

Variations for Ankylosis

Expression for Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for Ankylosis

Pathways related to Ankylosis according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 ACVR1 BMP2 BMP4 FGFR2 GNAI3 PLCB4
2
Show member pathways
13.17 ACVR1 BMP2 BMP4 FGFR2 GNAI3 PLCB4
3
Show member pathways
12.82 BMP2 BMP4 FGFR2 GNAI3 PLCB4
4 12.36 BMP2 BMP4 FGFR2 GNAI3 PLCB4
5
Show member pathways
12.15 BMP2 BMP4 GNAI3 PLCB4
6 11.9 BMP4 FGFR2 TNFRSF11B
7 11.88 ACVR1 BMP4 FGFR2
8
Show member pathways
11.88 ACVR1 BMP2 BMP4 FGFR2 GNAI3 NOG
9 11.55 ACVR1 BMP2 BMP4 NOG
10
Show member pathways
11.54 BMP2 NOG RUNX2
11 11.42 BMP4 NOG RUNX2
12 11.3 BGLAP FGFR2 RUNX2
13 11.26 BGLAP RUNX2 TNFRSF11B
14 11.22 BGLAP IBSP RUNX2
15 11.08 BGLAP BMP2 BMP4 NOG RUNX2 SP7
16 11.05 BGLAP IBSP PLCB4 RUNX2
17 11.04 GNAI3 PLCB4
18 10.98 BMP2 BMP4
19 10.92 BMP2 BMP4
20 10.58 BGLAP IBSP TNFRSF11B

GO Terms for Ankylosis

Cellular components related to Ankylosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 BGLAP BMP2 BMP4 FGFR2 IBSP NOG

Biological processes related to Ankylosis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.95 ACVR1 BMP2 FGFR2 NOG
2 cartilage development GO:0051216 9.86 BMP2 BMP4 NOG
3 positive regulation of epithelial cell proliferation GO:0050679 9.85 BMP4 FGFR2 NOG
4 odontogenesis of dentin-containing tooth GO:0042475 9.83 BMP2 BMP4 RUNX2
5 cell fate commitment GO:0045165 9.83 BMP2 BMP4 FGFR2
6 ossification GO:0001503 9.83 BGLAP BMP2 BMP4 RUNX2
7 bone development GO:0060348 9.82 BGLAP BMP4 FGFR2
8 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.81 ACVR1 BMP2 BMP4
9 positive regulation of osteoblast differentiation GO:0045669 9.8 ACVR1 BMP2 BMP4 RUNX2
10 ureteric bud development GO:0001657 9.79 BMP4 FGFR2 NOG
11 chondrocyte differentiation GO:0002062 9.79 BMP2 BMP4 RUNX2
12 cellular response to growth factor stimulus GO:0071363 9.78 BGLAP BMP2 BMP4 IBSP
13 epithelial to mesenchymal transition GO:0001837 9.77 BMP2 FGFR2 NOG
14 mesoderm formation GO:0001707 9.77 ACVR1 BMP4 NOG
15 embryonic cranial skeleton morphogenesis GO:0048701 9.76 BMP4 FGFR2 RUNX2
16 positive regulation of bone mineralization GO:0030501 9.75 ACVR1 BMP2 BMP4
17 odontogenesis GO:0042476 9.74 BGLAP BMP4 FGFR2
18 endoderm development GO:0007492 9.73 BMP4 NOG
19 pituitary gland development GO:0021983 9.73 BMP4 NOG
20 cardiac muscle cell differentiation GO:0055007 9.73 BMP2 BMP4
21 telencephalon development GO:0021537 9.73 BMP2 BMP4
22 endochondral ossification GO:0001958 9.73 BMP4 RUNX2
23 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.72 BMP2 BMP4
24 lung morphogenesis GO:0060425 9.72 BMP4 NOG
25 regulation of bone mineralization GO:0030500 9.72 ANKH BGLAP
26 anatomical structure formation involved in morphogenesis GO:0048646 9.72 BMP4 NOG
27 osteoblast development GO:0002076 9.71 BGLAP RUNX2
28 positive regulation of cartilage development GO:0061036 9.71 BMP2 BMP4
29 positive regulation of ossification GO:0045778 9.71 BMP2 BMP4
30 response to inorganic substance GO:0010035 9.71 BGLAP TNFRSF11B
31 regulation of osteoblast differentiation GO:0045667 9.71 FGFR2 RUNX2
32 outflow tract septum morphogenesis GO:0003148 9.71 ACVR1 BMP4 FGFR2
33 smooth muscle cell differentiation GO:0051145 9.7 ACVR1 BMP4
34 pathway-restricted SMAD protein phosphorylation GO:0060389 9.7 ACVR1 BMP2
35 regulation of ossification GO:0030278 9.7 ACVR1 RUNX2
36 mesodermal cell differentiation GO:0048333 9.7 BMP4 FGFR2
37 atrioventricular valve morphogenesis GO:0003181 9.69 ACVR1 BMP2
38 embryonic skeletal joint morphogenesis GO:0060272 9.69 BMP4 NOG
39 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.69 BMP2 RUNX2
40 endocardial cushion morphogenesis GO:0003203 9.69 ACVR1 BMP2 NOG
41 regulation of fibroblast growth factor receptor signaling pathway GO:0040036 9.68 FGFR2 RUNX2
42 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.68 BMP4 FGFR2
43 telencephalon regionalization GO:0021978 9.68 BMP2 BMP4
44 pharyngeal arch artery morphogenesis GO:0061626 9.67 BMP4 NOG
45 regulation of smooth muscle cell differentiation GO:0051150 9.67 BMP4 FGFR2
46 bud elongation involved in lung branching GO:0060449 9.66 BMP4 FGFR2
47 BMP signaling pathway GO:0030509 9.65 ACVR1 BMP2 BMP4 NOG RUNX2
48 prostate gland morphogenesis GO:0060512 9.64 BMP4 FGFR2
49 branching involved in prostate gland morphogenesis GO:0060442 9.64 BMP4 FGFR2
50 regulation of cell fate commitment GO:0010453 9.63 BMP4 FGFR2

Molecular functions related to Ankylosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 8.96 BMP2 BMP4
2 BMP receptor binding GO:0070700 8.62 BMP2 BMP4

Sources for Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
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37 KEGG
38 LifeMap
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42 MeSH
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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