Aliases & Classifications for Ankylosis

Aliases & Descriptions for Ankylosis:

Name: Ankylosis 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:227
ICD10 33 M24.6
ICD9CM 35 718.5 718.50
MeSH 42 D000844
UMLS 69 C0003090

Summaries for Ankylosis

Disease Ontology : 12 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary : Ankylosis is related to multiple synostoses syndrome and tooth ankylosis, and has symptoms including arthralgia, metatarsalgia and joint stiffness. An important gene associated with Ankylosis is ANKH (ANKH Inorganic Pyrophosphate Transport Regulator), and among its related pathways/superpathways are Pathways in cancer and Human Embryonic Stem Cell Pluripotency. The drugs Adalimumab and Certolizumab pegol have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and t cells, and related phenotypes are Decreased IL-13 protein expression and growth/size/body region

Wikipedia : 71 Ankylosis or anchylosis (from Greek ἀγκύλος, bent, crooked) is a stiffness of a joint due to... more...

Related Diseases for Ankylosis

Diseases related to Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
id Related Disease Score Top Affiliating Genes
1 multiple synostoses syndrome 31.2 BMP2 BMP4 NOG
2 tooth ankylosis 12.4
3 temporomandibular ankylosis 12.2
4 stapes ankylosis with broad thumb and toes 12.2
5 congenital temporomandibular joint ankylosis 11.9
6 glossopalatine ankylosis 11.8
7 craniostenosis, sagittal, with congenital heart disease, mental deficiency, and mandibular ankylosis 11.8
8 glossopalatine ankylosis micrognathia ear anomalies 11.7
9 arthropathy 11.7
10 fibrodysplasia ossificans progressiva 11.1
11 diffuse idiopathic skeletal hyperostosis 11.0
12 craniometaphyseal dysplasia 11.0
13 deafness, progressive, with stapes fixation 10.9
14 pfeiffer syndrome 10.8
15 restrictive dermopathy, lethal 10.8
16 auriculocondylar syndrome 2 10.8
17 johnson hall krous syndrome 10.7
18 distal arthrogryposis 10.7
19 piussan lenaerts mathieu syndrome 10.7
20 cardiocranial syndrome 10.7
21 auriculocondylar syndrome 1 10.7
22 hypoglossia-hypodactylia 10.7
23 syngnathia 10.7
24 proximal symphalangism 10.7
25 auriculocondylar syndrome 3 10.7
26 spondyloarthropathy 1 10.7
27 symphalangism, distal 10.7
28 symphalangism, proximal, 1a 10.7
29 arthritis 10.2
30 spondylitis 10.2
31 vaginal carcinosarcoma 10.1 BGLAP RUNX2
32 tarsal-carpal coalition syndrome 10.1 BMP2 BMP4 NOG
33 exudative vitreoretinopathy 4 10.1 ANKH BMP2 TNFRSF11B
34 muscular dystrophy-dystroglycanopathy 10.1 BMP2 NOG RUNX2
35 maroteaux stanescu cousin syndrome 10.1 BGLAP RUNX2 TNFRSF11B
36 acrorenal syndrome 10.1 BGLAP RUNX2 TNFRSF11B
37 celiac disease 10.1 ANKH BGLAP TNFRSF11B
38 rheumatoid arthritis 10.0
39 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.0 BMP2 IBSP TNFRSF11B
40 intrahepatic cholestasis 10.0 BGLAP RUNX2 TNFRSF11B
41 binocular vision disease 10.0 BMP2 PTH1R
42 malignant adult ependymoma 10.0 BGLAP PTH1R RUNX2
43 t cell immunodeficiency primary 10.0 BMP2 BMP4 NOG RUNX2
44 aneurysm, intracranial berry, 4 10.0 ACVR1 ANKH SP7
45 bladder papillary transitional cell neoplasm 10.0 BGLAP IBSP TNFRSF11B
46 chromosomal disease 10.0 BGLAP BMP2 RUNX2 TNFRSF11B
47 pancreas adenocarcinoma 10.0 BGLAP BMP2 RUNX2 TNFRSF11B
48 juvenile onset parkinson disease 19a 10.0 BGLAP BMP2 BMP4 RUNX2
49 splenic flexure cancer 10.0 BMP2 BMP4 NOG TNFRSF11B
50 epilepsy, idiopathic generalized 14 9.9 BGLAP TNFRSF11B

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to Ankylosis

Symptoms & Phenotypes for Ankylosis

UMLS symptoms related to Ankylosis:


arthralgia, metatarsalgia, joint stiffness, joint symptom

GenomeRNAi Phenotypes related to Ankylosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased IL-13 protein expression GR00219-A 8.62 FGFR2 ACVR1

MGI Mouse Phenotypes related to Ankylosis:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
2 cellular MP:0005384 10.15 ANKH BMP2 BMP4 FGFR2 NOG RUNX2
3 craniofacial MP:0005382 10.13 RUNX2 TNFRSF11B ACVR1 ANKH BMP2 BMP4
4 cardiovascular system MP:0005385 10.11 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
5 limbs/digits/tail MP:0005371 10.06 ANKH BMP2 BMP4 FGFR2 IBSP NOG
6 homeostasis/metabolism MP:0005376 10.02 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
7 digestive/alimentary MP:0005381 10 ACVR1 BMP2 BMP4 FGFR2 NOG PTH1R
8 mortality/aging MP:0010768 10 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
9 hearing/vestibular/ear MP:0005377 9.95 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
10 muscle MP:0005369 9.7 ACVR1 ANKH BMP4 FGFR2 NOG PLCB4
11 respiratory system MP:0005388 9.5 ANKH BMP4 FGFR2 NOG PTH1R RUNX2
12 skeleton MP:0005390 9.4 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP

Drugs & Therapeutics for Ankylosis

Drugs for Ankylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 2,Phase 3 331731-18-1 16219006
2
Certolizumab pegol Approved Phase 4,Phase 3,Phase 1 428863-50-7
3
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2 185243-69-0
4
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1 170277-31-3
5
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
6
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
7
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
8
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
9
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
10
Aceclofenac Approved Phase 4 89796-99-6
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
13
Pamidronate Approved Phase 4 40391-99-9 4674
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
15
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
16 Analgesics Phase 4,Phase 2,Phase 3
17 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
18 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
20 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
21 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
25 Natriuretic Agents Phase 4
26 Natriuretic Peptide, Brain Phase 4
27 Antimetabolites Phase 4,Phase 3,Phase 2
28 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
29 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
30 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
31 Vitamin B Complex Phase 4,Phase 3,Phase 2
32 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
33 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
34 Anti-Infective Agents Phase 4,Phase 2,Phase 3
35 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
36 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
37 Vaccines Phase 4,Phase 2
38 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
39 Bone Density Conservation Agents Phase 4
40 Endothelial Growth Factors Phase 4
41 Mitogens Phase 4
42 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
43 Antibiotics, Antitubercular Phase 4
44 Anticholesteremic Agents Phase 4
45 Cholestyramine Resin Phase 4
46 Hypolipidemic Agents Phase 4
47 Lipid Regulating Agents Phase 4
48 Analgesics, Opioid Phase 4
49 Central Nervous System Depressants Phase 4,Phase 3
50 Narcotics Phase 4

Interventional clinical trials:

(show top 50) (show all 282)
id Name Status NCT ID Phase
1 Investigation of Sacroiliac Fusion Treatment (INSITE) Unknown status NCT01681004 Phase 4
2 Gait Analysis of Ankle Arthroplasty and Arthrodesis Unknown status NCT00921076 Phase 4
3 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4
4 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4
5 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4
6 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4
7 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4
8 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
9 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4
10 Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel. Completed NCT01421303 Phase 4
11 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4
12 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4
13 Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS) Completed NCT01104987 Phase 4
14 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4
15 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4
16 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4
17 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
18 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
19 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
20 An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants Completed NCT00760669 Phase 4
21 Post Marketing Surveillance of Remicade Completed NCT00724529 Phase 4
22 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4
23 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4
24 Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis Completed NCT00544557 Phase 4
25 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4
26 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4
27 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4
28 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4
29 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4
30 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4
31 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4
32 Study Investigating Enbrel Treatment for Ankylosing Spondylitis Completed NCT00195416 Phase 4
33 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4
34 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
35 A Randomized, Double-blind, Placebo-controlled Multicenter Study of Secukinumab (AIN457) to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylit Recruiting NCT02763046 Phase 4
36 NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in the Spine in Ankylosing Spondylitis Recruiting NCT02758782 Phase 4
37 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Recruiting NCT02634541 Phase 4
38 Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA Recruiting NCT02509026 Phase 4
39 Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients Recruiting NCT02492217 Phase 4
40 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Active, not recruiting NCT02489760 Phase 4
41 Delaying Ossification and Improving Inflammation of Celebrex Plus/or Enbrel Treatment on Active Ankylosing Spondylitis Active, not recruiting NCT01934933 Phase 4
42 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Not yet recruiting NCT02638896 Phase 4
43 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Not yet recruiting NCT02313727 Phase 4
44 Enthesitis With Ultra Sonography Doppler in Spondyloarthropathies Treated With Infliximab (Study P04440) Terminated NCT00686894 Phase 4
45 Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem Terminated NCT01422564 Phase 4
46 Effects of Etanercept on the Heart, Veins and Thickness of Certain Major Arteries In Ankylosing Spondylitis Patients Terminated NCT00910273 Phase 4
47 An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs) Terminated NCT00766402 Phase 4
48 A Study to Assess the Safety and Effectiveness of Golimumab in Filipino Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Withdrawn NCT01692457 Phase 4
49 Effectiveness and Safety of Early Treatment With Infliximab for Hip Arthritis Associated With Ankylosing Spondylitis (AS) (P06451) Withdrawn NCT01148901 Phase 4
50 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4

Search NIH Clinical Center for Ankylosis

Cochrane evidence based reviews: ankylosis

Genetic Tests for Ankylosis

Anatomical Context for Ankylosis

MalaCards organs/tissues related to Ankylosis:

39
Bone, Skin, T Cells, Brain, Spleen, Tonsil

Publications for Ankylosis

Articles related to Ankylosis:

(show top 50) (show all 639)
id Title Authors Year
1
Application of a computer-assisted surgical navigation system in temporomandibular joint ankylosis surgery: a retrospective study. ( 27839946 )
2017
2
Ankylosis of the Temporomandibular Joint and Reconstruction With a Costochondral Graft in a Patient With Juvenile Idiopathic Arthritis. ( 27930467 )
2017
3
Ankylosis of the Finger in Erosive Osteoarthritis. ( 28090062 )
2017
4
Results and outcome predictors after open release of complete ankylosis of the elbow caused by heterotopic ossification. ( 28083670 )
2017
5
Simultaneous gap arthroplasty and intraoral distraction and secondary contouring surgery for unilateral temporomandibular joint ankylosis. ( 27014663 )
2016
6
Silicone vs temporalis fascia interposition in TMJ ankylosis: A comparison. ( 27195207 )
2016
7
A comparative study of different surgical methods in the treatment of traumatic temporomandibular joint ankylosis. ( 27658755 )
2016
8
Distraction osteogenesis in the treatment of temporomandibular joint ankylosis with mandibular micrognathia. ( 27563611 )
2016
9
Temporomandibular joint ankylosis contributing to coronoid process hyperplasia. ( 27173825 )
2016
10
Interpositional Gap Arthroplasty by Versatile Pedicled Temporalis Myofascial Flap in the Management of Temporomandibular Joint Ankylosis- A Case Series Study. ( 27891496 )
2016
11
Ankylosis of the temporomandibular joint secondary to neonatal group B streptococcal sepsis. ( 27678002 )
2016
12
Intraoperative mandibular nerve block with peripheral nerve stimulator for temporomandibular joint ankylosis. ( 27871523 )
2016
13
An unusual anterior dislocation of fractured mandibular condyle leading to psuedo-ankylosis in a 8 yr old child-A distinct case report. ( 27448226 )
2016
14
Heterotopic Ossification producing ankylosis should be considered when comparing arthroplasty to anterior cervical fusion. ( 26909828 )
2016
15
Role of bilateral mandibular distraction for asymmetry due to unilateral ankylosis. ( 27707606 )
2016
16
Single-stage temporomandibular joint arthroplasty in a patient with complete bony ankylosis and previous extradural haematoma. ( 28049115 )
2016
17
Temporomandibular Joint Ankylosis Can Be Successfully Treated With TMJ Concepts Patient-Fitted Total Joint Prosthesis and Autogenous Fat Grafts. ( 26878364 )
2016
18
Unilateral spontaneous ankylosis of the C1/C2 joint with "crowned dens syndrome": Computed tomography scan is imperative in diagnosis. ( 27695247 )
2016
19
Total Alloplastic Joint Reconstruction in a Patient With Temporomandibular Joint Ankylosis Following Condylar Dislocation Into the Middle Cranial Fossa. ( 27566458 )
2016
20
The sequential management of recurrent temporomandibular joint ankylosis in a growing child: a case report. ( 27774442 )
2016
21
Minimally Invasive Treatment of Temporomandibular Joint Ankylosis and Fibrosis of Temporalis Muscle. ( 27348948 )
2016
22
Bony ankylosis of hydroxyapatite prostheses in the middle ear. ( 26954869 )
2016
23
TMJ replacement utilizing patient-fitted TMJ TJR devices in a re-ankylosis child. ( 26920044 )
2016
24
Retrospective evaluation of airway management with blind awake intubation in temporomandibular joint ankylosis patients: A review of 48 cases. ( 27563608 )
2016
25
Improvement in the airway after mandibular distraction osteogenesis surgery in children with temporomandibular joint ankylosis and mandibular hypoplasia. ( 26909508 )
2016
26
Congenital Stapes Ankylosis in Children: Surgical Findings and Results in 35 Cases. ( 26945311 )
2016
27
Stapediovestibular ankylosis in an HIV/HCV-copositive patient. ( 26991224 )
2016
28
Conservative gap arthroplasty in temporomandibular ankylosis not involving the sigmoid notch: a selected age group study. ( 26972420 )
2016
29
Bilateral Scapulohumeral Ankylosis after Prolonged Mechanical Ventilation. ( 27583120 )
2016
30
Zurich pediatric distractor for ramal condylar unit distraction in temporomandibular joint ankylosis. ( 27563617 )
2016
31
Silicone Arthroplasty After Ankylosis of Proximal Interphalangeal Joints in Rheumatoid Arthritis: A Case Report. ( 27327930 )
2016
32
Influence of Dentoalveolar Ankylosis on the Biomechanical Response of a Single-rooted Tooth and Surrounding Alveolar Bone: AA 3-dimensional Finite Element Analysis. ( 27614415 )
2016
33
Case 229: Burn-related Global Ankylosis of Interphalangeal Joints with Associated Acroosteolysis. ( 27089192 )
2016
34
Supracondylar femoral osteotomy and knee joint replacement during the same surgical procedure in a type A haemophiliac patient with knee flexion deformity and ankylosis. ( 27919671 )
2016
35
Surgical Treatment of Neglected Traumatic Quadriceps Tendon Rupture with Knee Ankylosis. ( 27274474 )
2016
36
Stylo-mandibular fusion complicating recurrent bilateral temporomandibular joint ankylosis. ( 26837637 )
2016
37
Bony ankylosis of the facet joint of the cervical spine in rheumatoid arthritis: Its characteristics and relationship to the clinical findings. ( 27919200 )
2016
38
One stage treatment of temporomandibular joint complete bony ankylosis using total joint replacement. ( 26897300 )
2016
39
Ankylosis and pseudoankylosis of the temporomandibular joint in 10 dogs (1993-2015). ( 27439984 )
2016
40
Coronoid process and residual ankylotic mass as an autograft in the management of ankylosis of the temporomandibular joint in young adolescent patients: a retrospective clinical investigation. ( 26851147 )
2016
41
Re: Agarwal et al. Stylomandibular fusion that complicates recurrent bilateral ankylosis of the temporomandibular joint. ( 27131983 )
2016
42
Bilaterally Primary Cementless Total Hip Arthroplasty for Severe Hip Ankylosis with Ankylosing Spondylitis. ( 27627719 )
2016
43
Total Ankylosis of the Upper Left Limb: A Case of Progressive Osseous Heteroplasia. ( 27517079 )
2016
44
Spontaneous Knee Ankylosis through Heterotopic Ossification after Total Knee Arthroplasty. ( 27119034 )
2016
45
Temporomandibular joint ankylosis after condylar dislocation into the middle cranial fossa: A case report. ( 27473929 )
2016
46
A multidisciplinary approach to the management of temporomandibular joint ankylosis in a sickle-cell anemia patient in a resource-limited setting. ( 27563622 )
2016
47
Congenital Temporomandibular Joint Ankylosis: Case Report and Literature Review. ( 27190665 )
2016
48
Surgical correction without bone grafts of maxillofacial asymmetric deformities in patients treated for unilateral temporomandibular joint ankylosis. ( 27614813 )
2016
49
The progressive ankylosis protein ANK facilitates clathrin- and adaptor-mediated membrane traffic at the trans-Golgi network-to-endosome interface. ( 27466194 )
2016
50
Use of Ultrasonography for Assessing Treatment Efficacy in a Case With Ankylosis of the Temporomandibular Joint. ( 26928737 )
2016

Variations for Ankylosis

Expression for Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for Ankylosis

GO Terms for Ankylosis

Cellular components related to Ankylosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 BGLAP BMP2 BMP4 FGFR2 IBSP NOG
2 extracellular space GO:0005615 9.1 BGLAP BMP2 BMP4 IBSP NOG TNFRSF11B

Biological processes related to Ankylosis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.96 ACVR1 BMP2 FGFR2 NOG
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 BMP2 BMP4 FGFR2
3 positive regulation of cell migration GO:0030335 9.91 ACVR1 BMP2 BMP4
4 negative regulation of gene expression GO:0010629 9.9 BMP2 BMP4 NOG
5 cartilage development GO:0051216 9.86 BMP2 BMP4 NOG
6 positive regulation of epithelial cell proliferation GO:0050679 9.85 BMP4 FGFR2 NOG
7 odontogenesis of dentin-containing tooth GO:0042475 9.84 BMP2 BMP4 RUNX2
8 cell fate commitment GO:0045165 9.83 BMP2 BMP4 FGFR2
9 cellular response to growth factor stimulus GO:0071363 9.83 BGLAP BMP2 BMP4 IBSP
10 bone development GO:0060348 9.82 BGLAP BMP4 FGFR2
11 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.81 ACVR1 BMP2 BMP4
12 positive regulation of osteoblast differentiation GO:0045669 9.81 ACVR1 BMP2 BMP4 RUNX2
13 ureteric bud development GO:0001657 9.8 BMP4 FGFR2 NOG
14 epithelial to mesenchymal transition GO:0001837 9.79 BMP2 FGFR2 NOG
15 mesoderm formation GO:0001707 9.78 ACVR1 BMP4 NOG
16 positive regulation of bone mineralization GO:0030501 9.77 ACVR1 BMP2 BMP4
17 embryonic cranial skeleton morphogenesis GO:0048701 9.77 BMP4 FGFR2 RUNX2
18 ossification GO:0001503 9.77 BGLAP BMP2 BMP4 PTH1R RUNX2
19 odontogenesis GO:0042476 9.76 BGLAP BMP4 FGFR2
20 chondrocyte differentiation GO:0002062 9.76 BMP2 BMP4 PTH1R RUNX2
21 ventricular septum morphogenesis GO:0060412 9.74 ACVR1 NOG
22 endoderm development GO:0007492 9.73 BMP4 NOG
23 cardiac muscle cell differentiation GO:0055007 9.73 BMP2 BMP4
24 telencephalon development GO:0021537 9.73 BMP2 BMP4
25 endochondral ossification GO:0001958 9.73 BMP4 RUNX2
26 outflow tract septum morphogenesis GO:0003148 9.73 ACVR1 BMP4 FGFR2
27 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 9.72 BMP2 BMP4
28 lung morphogenesis GO:0060425 9.72 BMP4 NOG
29 regulation of bone mineralization GO:0030500 9.72 ANKH BGLAP
30 anatomical structure formation involved in morphogenesis GO:0048646 9.72 BMP4 NOG
31 positive regulation of cartilage development GO:0061036 9.72 BMP2 BMP4
32 osteoblast development GO:0002076 9.72 BGLAP PTH1R RUNX2
33 BMP signaling pathway GO:0030509 9.72 ACVR1 BMP2 BMP4 NOG RUNX2
34 positive regulation of ossification GO:0045778 9.71 BMP2 BMP4
35 response to inorganic substance GO:0010035 9.71 BGLAP TNFRSF11B
36 regulation of ossification GO:0030278 9.71 ACVR1 RUNX2
37 smooth muscle cell differentiation GO:0051145 9.71 ACVR1 BMP4
38 endocardial cushion morphogenesis GO:0003203 9.71 ACVR1 BMP2 NOG
39 regulation of osteoblast differentiation GO:0045667 9.7 FGFR2 RUNX2
40 pathway-restricted SMAD protein phosphorylation GO:0060389 9.7 ACVR1 BMP2
41 mesodermal cell differentiation GO:0048333 9.7 BMP4 FGFR2
42 atrioventricular valve morphogenesis GO:0003181 9.7 ACVR1 BMP2
43 embryonic skeletal joint morphogenesis GO:0060272 9.69 BMP4 NOG
44 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.69 BMP2 RUNX2
45 regulation of fibroblast growth factor receptor signaling pathway GO:0040036 9.69 FGFR2 RUNX2
46 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.68 BMP4 FGFR2
47 bud elongation involved in lung branching GO:0060449 9.68 BMP4 FGFR2
48 telencephalon regionalization GO:0021978 9.68 BMP2 BMP4
49 pharyngeal arch artery morphogenesis GO:0061626 9.67 BMP4 NOG
50 regulation of smooth muscle cell differentiation GO:0051150 9.67 BMP4 FGFR2

Molecular functions related to Ankylosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide hormone binding GO:0017046 9.16 ACVR1 PTH1R
2 co-receptor binding GO:0039706 8.96 BMP2 BMP4
3 BMP receptor binding GO:0070700 8.62 BMP2 BMP4

Sources for Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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