MCID: ANK001
MIFTS: 51

Ankylosis malady

Summaries for Ankylosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. the rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards: Ankylosis is related to arthropathy and arthritis. An important gene associated with Ankylosis is ANKH (ANKH inorganic pyrophosphate transport regulator), and among its related pathways are Osteoblast Signaling and TGF-beta Signaling Pathway. The compounds methylmethacrylate and alizarin have been mentioned in the context of this disorder. Affiliated tissues include spleen, brain and spinal cord, and related mouse phenotypes are hearing/vestibular/ear and limbs/digits/tail.

Wikipedia:64 Ankylosis or anchylosis (from Greek ἀγκύλος, bent, crooked) is a stiffness of a joint due to... more...

Aliases & Classifications for Ankylosis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

ankylosis 8 10 61


External Ids:

Disease Ontology8 DOID:227
ICD9CM27 718.50, 718.5
MeSH35 D000844

Related Diseases for Ankylosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Ankylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 465)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy30.6ANKH, BMP2, TNFRSF11B
2arthritis30.5TNFRSF11B, BMP2, ANKH, GDF5
3ankylosing spondylitis30.5ERAP1
4fibrodysplasia ossificans progressiva30.1NOG, BMP2
5proximal symphalangism29.8NOG, GDF5
6otosclerosis29.8TNFRSF11B, NOG
7hypophosphatemia29.6DSPP
8cleft palate29.6BMP2, DSPP
9progressive osseous heteroplasia29.6BMP2, NOG
10root resorption29.6GDF5, BMP2, TNFRSF11B, HEBP1
11osteoarthritis29.6TNFRSF11B, BMP2, DSPP, ANKH, GDF5
12temporomandibular ankylosis11.0
13tooth ankylosis10.4
14spondylitis10.3
15congenital temporomandibular joint ankylosis10.3
16spondyloarthropathy10.1
17stapes ankylosis with broad thumb and toes10.1
18septic arthritis10.1
19multiple epiphyseal dysplasia10.0
20cardiocranial syndrome10.0
21polyarticular onset juvenile idiopathic arthritis10.0
22mucopolysaccharidosis ih10.0
23synostosis10.0NOG
24periodontitis10.0TNFRSF11B
25syndactyly10.0NOG, GDF5
26osteonecrosis10.0BMP2
27brachydactyly10.0NOG, GDF5
28dental enamel hypoplasia10.0HEBP1, DSPP
29osteosclerosis10.0TNFRSF11B, BMP2
30hyperphosphatemia10.0TNFRSF11B, BMP2
31osteogenesis imperfecta10.0DSPP, PTH1R, SP7
32metaphyseal dysplasia10.0PTH1R
33hypophosphatasia10.0DSPP
34craniosynostosis10.0NOG, ANKH, BMP2
35secondary syphilis10.0PTH1R, BMP2, TNFRSF11B
36aortic valve stenosis10.0BMP2, TNFRSF11B
37spondylolisthesis10.0BMP2
38osteoporosis10.0SP7, PTH1R, NOG, BMP2, TNFRSF11B
39hypertrophy of breast10.0BMP2, GDF5, NOG, PTH1R, SETD2
40breast cancer10.0TNFRSF11B, BMP2, PTH1R, SETD2
41osteosarcoma10.0TNFRSF11B, BMP2, PTH1R, SETD2, SP7
42psoriatic arthritis10.0
43noma10.0
44glossopalatine ankylosis micrognathia ear anomalies10.0
45hyperopia10.0
46glossopalatine ankylosis10.0
47marfan syndrome9.9
48diffuse idiopathic skeletal hyperostosis9.9
49williams-beuren syndrome9.9
50sapho syndrome9.9

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to ankylosis

Clinical Features for Ankylosis

Drugs & Therapeutics for Ankylosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Ankylosis

Drug clinical trials:

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Search CenterWatch for Ankylosis

Genetic Tests for Ankylosis

Anatomical Context for Ankylosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Ankylosis:

33
Spleen, Brain, Spinal cord, Skeletal muscle, Skin, Tonsil, T cells, B cells

Animal Models for Ankylosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Ankylosis

Sources:
51PubMed
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Articles related to Ankylosis:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Management of recurrent ankylosis in arthrogryposis: new solutions to a rare problem. (22652440)
2013
2
Ankylosis of temporomandibular joint after the traumatic brain injury: a report of two cases. (22008514)
2013
3
Posttraumatic bifid and trifid mandibular condyle with bilateral temporomandibular joint ankylosis. (23524825)
2013
4
Pathologic thoracic spine fracture in presence of Parkinson's disease and diffuse ankylosis: successful management of a challenging condition. (23394219)
2013
5
Fibrodysplasia ossificans progressiva (FOP): report of a case with extra-articular ankylosis of the mandible. (23510591)
2013
6
The role of three-dimensional computed tomography in the evaluation of temporomandibular joint ankylosis. (23066255)
2012
7
Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo. (22121131)
2012
8
Complete ankylosis in longterm HLA-B27-negative psoriatic arthritis. (23118280)
2012
9
Aetiology and presentation of ankylosis of the temporomandibular joint: report of 23 cases from Abuja, Nigeria. (21255886)
2012
10
The laryngeal mask airway for difficult airway in temporomandibular joint ankylosis--a case report. (23327041)
2012
11
Spontaneous re-eruption of a permanent maxillary central incisor after 15 years of ankylosis--a case report. (21790990)
2012
12
Use of the suture anchor in interpositional arthroplasty of temporomandibular joint ankylosis. (21710146)
2012
13
Alcohol-facilitated ankylosis of the distal intertarsal and tarsometatarsal joints in horses with osteoarthritis. (22217029)
2012
14
Inappropriate use of foreign materials in temporomandibular joint ankylosis surgery: report of two cases. (21303319)
2011
15
Treatment of ankylosis of the mandibular first molar with orthodontic traction immediately after surgical luxation. (21889085)
2011
16
Retrospective analysis of use of buccal fat pad as an interpositional graft in temporomandibular joint ankylosis: preliminary study. (21664741)
2011
17
First descriptions of the ankylosis of the stapes. (20634772)
2010
18
A Retrospective Study of Temporalis Muscle and Fascia Flap in Treatment of TMJ Ankylosis. (22190825)
2010
19
Long term results of cementless total hip replacement for reversal of hip ankylosis. (19462368)
2009
20
Induction of traumatic temporomandibular joint ankylosis in growing rats: a preliminary experimental study. (19208027)
2009
21
Decoronation as an approach to treat ankylosis in growing children. (19455930)
2009
22
From ankylosis to pencil-in-cup deformity in psoriatic arthritis: a case report. (19772803)
2009
23
SAPHO syndrome with temporomandibular joint ankylosis: clinical, radiological, histopathological, and therapeutical correlations. (18280950)
2008
24
Small joint ankylosis in rheumatoid arthritis: a vanishing phenomenon or a pathogenetic clue, or both? (19005157)
2008
25
Video assisted fiberoptic intubation for temporomandibular ankylosis. (16618303)
2006
26
Bilateral fibrous ankylosis of temporomandibular joint associated with ankylosing spondylitis: a case report. (16626998)
2006
27
Anaesthesia for a patient with congenital methaemoglobinaemia and temporomandibular joint ankylosis. (16494156)
2006
28
Severe proliferative congenital temporomandibular joint ankylosis: a proposed treatment protocol utilizing distraction osteogenesis. (16770209)
2006
29
Ankylosis of traumatized permanent incisors: pathogenesis and current approaches to diagnosis and management. (16324230)
2005
30
Difficult intubation related to ankylosis of temporomandibular joint after craniotomy. (16037743)
2005
31
Facilitated ankylosis of the distal interphalangeal joint in a foal. (15181928)
2004
32
Case report: severe infraocclusion ankylosis occurring in siblings. (15471527)
2004
33
Atlantoaxial rotatory subluxation with ankylosis in an 11-year-old girl: a case report. (15014285)
2004
34
Denervation resulting in dento-alveolar ankylosis associated with decreased Malassez epithelium. (15271971)
2004
35
Temporomandibular joint ankylosis: report of 14 cases. (12653228)
2003
36
Ankylosis of the jaw in a patient with fibrodysplasia ossificans progressiva. (14676758)
2003
37
Extra-articular ankylosis of the mandible caused by possible migration of bone grafts. (14520077)
2003
38
Airway management of a child with temporomandibular joint ankylosis following otitis media 2. (12437736)
2002
39
Preserved costal cartilage homograft application for the treatment of temporomandibular joint ankylosis. (11420503)
2001
40
Polypeptide growth factors and phorbol ester induce progressive ankylosis (ank) gene expression in murine and human fibroblasts. (11746513)
2001
41
Total knee arthroplasty after spontaneous osseous ankylosis and takedown of formal knee fusion. (10884205)
2000
42
Extra-articular ankylosis of the mandible after failed orthognathic surgery: report of a case. (11117701)
2000
43
Bone dynamics of osseointegration, ankylosis, and tooth movement. (11992943)
1999
44
Bird face deformity secondary to bilateral temporomandibular joint ankylosis. (8773891)
1996
45
An analytic study of surgical management of the temporomandibular joint ankylosis: an experience in Bangladesh. (9037844)
1996
46
Primary tooth ankylosis: report of case with histological analysis. (7560370)
1995
47
Modified functional distraction appliance. An appliance for chronic lock and ankylosis. (8697501)
1995
48
Treatment of TMJ ankylosis. (8310044)
1994
49
Experimental tooth ankylosis and horizontal tooth movement in the pig. (7025810)
1981
50
Measurement of space loss resulting from tooth ankylosis. (4879576)
1968

Genetic Variations for Ankylosis

Expression for genes affiliated with Ankylosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for genes affiliated with Ankylosis

Sources:
38NCBI BioSystems Database, 56SinoBiological, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Ankylosis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB, 2BitterDB, 29IUPHAR
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Compounds related to Ankylosis according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1methylmethacrylate4510.4DSPP, BMP2
2alizarin4510.4BMP2, SP7
3teriparatide45 1111.3PTH1R, TNFRSF11B
4alendronate45 50 1112.3DSPP, BMP2, TNFRSF11B
5hydroxyapatite4510.2ANKH, DSPP, BMP2, TNFRSF11B
6polyglycolic acid4510.1BMP2, DSPP
7calcitriol45 60 11 2413.1TNFRSF11B, BMP2, DSPP, PTH1R
8azathioprine45 50 2 1113.1NOG, BMP2, TNFRSF11B
9vitamin d4510.0PTH1R, DSPP, BMP2, TNFRSF11B
10ascorbic acid45 2410.9TNFRSF11B, BMP2, DSPP, SETD2, SP7
111,25 dihydroxy vitamin d3459.9PTH1R, BMP2, TNFRSF11B
12tgf beta1459.9SETD2, BMP2, TNFRSF11B
13pyrophosphate45 2410.9TNFRSF11B, GUK1, ANKH, MARS2
14dexamethasone45 50 29 1112.8TNFRSF11B, BMP2, DSPP, NOG, PTH1R, SP7
15vegf459.7TNFRSF11B, BMP2, NOG, ERAP1, SETD2, SP7
16dihydrotestosterone45 29 11 2412.6SETD2, BMP2, TNFRSF11B
17serine459.5TNFRSF11B, BMP2, GUK1, TAF1, SLC20A2, NOG
18calcium45 50 11 2412.2TNFRSF11B, BMP2, GUK1, DSPP, ANKH, NOG

GO Terms for genes affiliated with Ankylosis

Sources:
16Gene Ontology
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Biological processes related to Ankylosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1osteoblast differentiationGO:00164910.2SP7, NOG, BMP2
2pericardium developmentGO:06003910.2SETD2, BMP2
3growthGO:04000710.1BMP2, GDF5, GDF7
4BMP signaling pathwayGO:03050910.1NOG, GDF7, BMP2
5cartilage developmentGO:05121610.1GDF5, DLX2, NOG
6pathway-restricted SMAD protein phosphorylationGO:06038910.0BMP2, GDF7
7cellular response to BMP stimulusGO:0717739.9NOG, BMP2
8skeletal system developmentGO:0015019.8PTH1R, NOG, ANKH, DSPP, BMP2, TNFRSF11B
9extracellular matrix organizationGO:0301989.8GDF5, TRAPPC4, BMP2, TNFRSF11B
10positive regulation of transcription from RNA polymerase II promoterGO:0459449.6SP7, NOG, TAF1, DLX2, BMP2

Molecular functions related to Ankylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inorganic phosphate transmembrane transporter activityGO:0053159.9SLC20A2, ANKH
2cytokine activityGO:0051259.8GDF7, GDF5, BMP2, TNFRSF11B

Products for genes affiliated with Ankylosis

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Sources for Ankylosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet