MCID: ANK001
MIFTS: 57

Ankylosis malady

Bone diseases category
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Summaries for Ankylosis

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Disease Ontology:8 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. the rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary: Ankylosis is related to arthropathy and fibrodysplasia ossificans progressiva. An important gene associated with Ankylosis is ANKH (ANKH inorganic pyrophosphate transport regulator), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Basal cell carcinoma. The compounds methylmethacrylate and echinomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spleen, and related mouse phenotypes are limbs/digits/tail and hearing/vestibular/ear.

Wikipedia:65 Ankylosis or anchylosis (from Greek ???????, bent, crooked) is a stiffness of a joint due to abnormal... more...

Aliases & Classifications for Ankylosis

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Ankylosis, Aliases & Descriptions:

Name: Ankylosis 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:227
ICD9CM27 718.50, 718.5
MeSH34 D000844

Related Diseases for Ankylosis

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Diseases related to Ankylosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 502)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy31.0BMP2, TNFRSF11B, ANKH
2fibrodysplasia ossificans progressiva30.7NOG, BMP2
3multiple synostosis syndrome 130.5NOG
4arthritis30.5ANKH, BMP2, GDF5, TNFRSF11B, TGFB1
5otosclerosis30.1TGFB1, TNFRSF11B, NOG
6progressive osseous heteroplasia30.0BMP2, NOG, ENPP1
7root resorption29.8GDF5, TNFRSF11B, HEBP1, BMP2
8osteoarthritis29.0TNFRSF11B, TGFB1, DSPP, ANKH, BMP2, ENPP1
9temporomandibular ankylosis10.6
10auriculocondylar syndrome 110.5GNAI3
11spondylolisthesis10.5BMP2
12degenerative disc disease10.5BMP2
13tooth ankylosis10.5
14rickets10.5HEBP1, DSPP
15dental enamel hypoplasia10.4HEBP1, DSPP
16ankylosing spondylitis10.4
17spondylitis10.4
18brachydactyly type a210.4BMP2, GDF5
19pseudogout10.3ANKH, ENPP1
20brachydactyly10.3GDF5, NOG
21x-linked hypophosphatemia10.3ENPP1, DSPP
22hypophosphatasia10.3ENPP1, DSPP
23osteosclerosis10.3TNFRSF11B, BMP2
24gingivitis10.3TNFRSF11B, DSPP
25arterial calcification of infancy10.3SLC20A2, ENPP1
26gingival overgrowth10.3DSPP, TGFB1
27calcinosis10.3ANKH, ENPP1
28aortic valve stenosis10.3BMP2, TNFRSF11B
29osteogenesis imperfecta10.3DSPP, SP7
30ameloblastoma10.3DSPP, TNFRSF11B
31hyperphosphatemia10.2TNFRSF11B, BMP2
32rheumatoid arthritis10.2
33stapes ankylosis with broad thumb and toes10.2
34retinal ischemia10.2SETD2, HIF1A
35spondyloarthropathy10.2
36erythrocytosis10.2HIF1A, SETD2
37septic arthritis10.1
38congenital temporomandibular joint ankylosis10.1
39factor v leiden thrombophilia10.1DSPP, BMP2, SETD2
40craniosynostosis10.1ENPP1, BMP2, ANKH, NOG
41psoriatic arthritis10.1
42distal arthrogryposis10.1
43laryngitis10.1
44cardiocranial syndrome10.1
45polyarticular onset juvenile idiopathic arthritis10.1
46pulmonary hypertension10.1HIF1A, BMP2, SETD2
47non-small cell lung carcinoma10.0HIF1A, SETD2, BMP2
48diabetic nephropathy10.0ENPP1, BMP2, TGFB1
49mucopolysaccharidosis i10.0
50noma10.0

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to ankylosis

Symptoms for Ankylosis

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Drugs & Therapeutics for Ankylosis

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Drug clinical trials:

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Genetic Tests for Ankylosis

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Anatomical Context for Ankylosis

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MalaCards organs/tissues related to Ankylosis:

32
Bone, Skin, Spleen, Brain, Tonsil, T cells

Animal Models for Ankylosis or affiliated genes

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Publications for Ankylosis

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Articles related to Ankylosis:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Identification of two novel mutations in the NOG gene associated with congenital stapes ankylosis and symphalangism. (25391606)
2014
2
Ankylosis of Temporomandibular Joint caused by Psoriatic Arthritis: A Report of Four Cases with Literature Review. (25028690)
2014
3
Fat metaplasia and backfill are key intermediaries in the development of sacroiliac joint ankylosis in patients with ankylosing spondylitis. (25047851)
2014
4
Temperomandibular joint ankylosis in children. (25210367)
2014
5
Persistent stapedial artery with stapes ankylosis. (25194854)
2014
6
Congenital cheek teratoma with temporo-mandibular joint ankylosis managed with ultra-thin silicone sheet interpositional arthroplasty. (24163567)
2013
7
Axial involvement with facet joint arthropathy and bony ankylosis in a case of camptodactyly, arthropathy, coxa vara, pericarditis (CACP) syndrome. (23931850)
2013
8
Management of recurrent ankylosis in arthrogryposis: new solutions to a rare problem. (22652440)
2013
9
The role of three-dimensional computed tomography in the evaluation of temporomandibular joint ankylosis. (23066255)
2012
10
Selecting reconstruction option for TMJ ankylosis: a surgeon's dilemma. (23147341)
2012
11
Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo. (22121131)
2012
12
Two-stage total prosthetic reconstruction of temporomandibular joint in severe and recurrent ankylosis. (22976729)
2012
13
Overgrowth of costochondral graft in temporomandibular joint ankylosis: An unusual case. (22639507)
2011
14
Subankylotic ostectomy for release of TMJ ankylosis using the transmasseteric anterior parotid approach. (22134263)
2011
15
Ankylosis of permanent first molars: genetics or environment? A case report of a discordant twin pair. (21288789)
2011
16
Versatility of full thickness skin-subcutaneous fat grafts as interpositional material in the management of temporomandibular joint ankylosis. (20952163)
2011
17
Bifid mandibular condyle with ankylosis in a 3-year-old child: A rare presentation and review. (22114377)
2010
18
A new hypothesis of mechanisms of traumatic ankylosis of temporomandibular joint. (19261390)
2009
19
Infliximab in severe active ankylosing spondylitis with spinal ankylosis. (18336538)
2008
20
Minimum 1-year follow-up for patients with vertical shear sacroiliac joint dislocations treated with iliosacral screws: does joint ankylosis or anatomic reduction contribute to functional outcome? (18448980)
2008
21
Random control trial of dermis-fat graft and interposition of temporalis fascia in the management of temporomandibular ankylosis in children. (18420320)
2008
22
Development of temporomandibular joint ankylosis in rats: a preliminary experimental study. (18178382)
2008
23
Temporo mandibular joint ankylosis. (18392499)
2008
24
Surgical management of temporomandibular joint ankylosis. (19098556)
2008
25
Two-stage treatment of TMJ ankylosis by early surgical approach and distraction osteogenesis. (17251865)
2007
26
Video assisted fiberoptic intubation for temporomandibular ankylosis. (16618303)
2006
27
Report of ankylosis of the temporomandibular joint: treatment with a temporalis muscle flap and augmentation genioplasty. (16491155)
2006
28
Ankylosis due to heterotopic ossification following primary total knee arthroplasty. (17009834)
2006
29
Aesthetic veneer restoration of an anterior dentition postorthodontics complicated by ankylosis. (16358806)
2005
30
Formation and resolution of ankylosis under application of recombinant human bone morphogenetic protein-2 (rhBMP-2) to class III furcation defects in cats. (15966907)
2005
31
Ankylosis of traumatized permanent incisors: pathogenesis and current approaches to diagnosis and management. (16324230)
2005
32
The interpositional dermis-fat graft in the management of temporomandibular joint ankylosis. (15556322)
2004
33
Treatment of post-stroke ankylosis by warm-needling. (15688698)
2004
34
Treatment of temporomandibular joint ankylosis by a modified fossa prosthesis. (15262255)
2004
35
Stiffness and ankylosis in primary total knee arthroplasty. (14646741)
2003
36
Navigation-guided resection of temporomandibular joint ankylosis promotes safety in skull base surgery. (12420260)
2002
37
Total knee arthroplasty after spontaneous osseous ankylosis and takedown of formal knee fusion. (10884205)
2000
38
Unusual ankylosis of the jaw due to fibrodysplasia ossificans progressiva. (10560885)
1999
39
Ankylosing spondylitis: time to focus on ankylosis. (10229392)
1999
40
Zygomatico-coronoid ankylosis: a case report. (10416891)
1999
41
Arthroscopic laser debridement of temporomandibular joint fibrous and bony ankylosis: case report. (9734776)
1998
42
Sloppy hinge prosthetic elbow replacement for post-traumatic ankylosis or instability. (9699822)
1998
43
Management of post-traumatic temporomandibular joint ankylosis in children: case report. (7498034)
1995
44
Pagetic vertebral ankylosis and diffuse idiopathic skeletal hyperostosis. (7747229)
1995
45
Treatment of elbow ankylosis by means of transplantation of the entire joint. Preliminary communication. 1908. (8194253)
1994
46
Phosphocitrate prevents disease progression in murine progressive ankylosis. (8240437)
1993
47
Myositis ossificans of medial pterygoid muscle. A cause for temporomandibular joint ankylosis. (1603562)
1992
48
Progressive ankylosis (ank/ank) in mice: an animal model of spondyloarthropathy. III. Proliferative spleen cell response to T cell mitogens. (2805429)
1989
49
Simultaneous total correction of temporomandibular ankylosis and facial asymmetry. (3513227)
1986
50
Surgical release of bilateral, intractable, temporomandibular ankylosis. (472055)
1979

Variations for Ankylosis

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Expression for genes affiliated with Ankylosis

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Expression patterns in normal tissues for genes affiliated with Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for genes affiliated with Ankylosis

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Pathways related to Ankylosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLCB4, GNAI3
2
Show member pathways
9.5GNAI3, BMP2, PLCB4
3
Show member pathways
9.5BMP2, TGFB1, GDF5
49.4BMP2, TGFB1, HIF1A
5
Show member pathways
9.3BMP2, DSPP, TGFB1, GDF5
69.3GDF5, TGFB1, BMP2, NOG
7
Show member pathways
9.3GNAI3, TGFB1, BMP2, NOG
89.0GDF5, GDF7, TGFB1, BMP2
9
Show member pathways
8.9GDF5, GNAI3, HIF1A, TGFB1, BMP2
10
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
11
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
12
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
13
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
14
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
15
Show member pathways
8.8GDF5, GNAI3, TGFB1, BMP2, PLCB4
16
Show member pathways
8.8NOG, BMP2, TGFB1, GDF7, GDF5
17
Show member pathways
8.5GDF5, GNAI3, TNFRSF11B, TGFB1, BMP2, PLCB4
18
Show member pathways
8.5GDF5, GNAI3, HIF1A, TGFB1, BMP2, PLCB4
19
Show member pathways
7.7GNAI3, HIF1A, TGFB1, HEBP1, BMP2, PLCB4

Compounds for genes affiliated with Ankylosis

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Compounds related to Ankylosis according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1methylmethacrylate4410.3BMP2, DSPP
2echinomycin4410.2SETD2, HIF1A
33-(5-hydroxymethyl-2-furyl)-1-benzylindazole4410.2HIF1A, SETD2
4alizarin red s4410.2TGFB1, BMP2
5deferoxamine mesylate4410.1HIF1A, SETD2
6alendronate44 50 1112.1TNFRSF11B, DSPP, BMP2
7alizarin4410.1SP7, BMP2
8pimonidazole4410.0HIF1A, SETD2
9cocl24410.0SETD2, HIF1A
10halothane44 50 28 1112.9HIF1A, SETD2, DSPP
11pmma449.9TNFRSF11B, TGFB1, DSPP
12nitroglycerin44 1110.9TNFRSF11B, HIF1A, SETD2
13bortezomib44 50 1111.8SETD2, HIF1A, TNFRSF11B
14tetracycline44 1110.8TGFB1, BMP2, DSPP
15procollagen449.7BMP2, TGFB1, TNFRSF11B
16ns 39844 6110.7TNFRSF11B, TGFB1, HIF1A
17diphenyleneiodonium449.7SETD2, TGFB1, HIF1A
18heparan sulfate44 2410.7PLCB4, BMP2, TNFRSF11B, NOG
19neomycin449.7PLCB4, TGFB1, BMP2
20pdtc449.6SETD2, TGFB1, HIF1A
21calcitriol44 61 24 1112.6TGFB1, BMP2, DSPP, TNFRSF11B
22hydroxyapatite449.6ANKH, DSPP, ENPP1, TNFRSF11B, BMP2
23azathioprine44 2 50 1112.6TNFRSF11B, NOG, BMP2
24tgf beta1449.6TGFB1, SETD2, BMP2, TNFRSF11B
25vitamin d449.5BMP2, TNFRSF11B, TGFB1, DSPP
26rapamycin449.4ENPP1, HIF1A, SETD2, BMP2
27pyrophosphate44 2410.3ANKH, GUK1, ENPP1, TNFRSF11B
28lactate449.3TGFB1, SETD2, DSPP, BMP2, HIF1A
29genistein44 28 61 2 24 1114.2TNFRSF11B, HIF1A, SETD2, BMP2, PLCB4
30ascorbic acid44 2410.2TNFRSF11B, SP7, HIF1A, SETD2, BMP2, DSPP
31dihydrotestosterone44 28 24 1112.2BMP2, HIF1A, TNFRSF11B, SETD2, TGFB1
32sb 20358044 6110.2TGFB1, SETD2, BMP2, HIF1A, TNFRSF11B
33pge2449.2HIF1A, SETD2, TNFRSF11B, BMP2, TGFB1
34ly294002449.1SETD2, TNFRSF11B, HIF1A, TGFB1
35pd 98,059449.1TGFB1, SETD2, BMP2, PLCB4, HIF1A
36doxorubicin44 50 1111.0TNFRSF11B, HIF1A, TGFB1, SETD2
37cycloheximide449.0TNFRSF11B, NOG, BMP2, SETD2, TGFB1, HIF1A
38arginine449.0SLC20A2, BMP2, DSPP, HIF1A, PLCB4
39estrogen448.9TNFRSF11B, HIF1A, TGFB1, SETD2, BMP2, DSPP
40threonine448.9TGFB1, SETD2, HIF1A, GDF5, ENPP1, BMP2
41retinoic acid44 249.9SETD2, HIF1A, BMP2, NOG, TGFB1, TNFRSF11B
42cysteine448.9HIF1A, GDF5, PLCB4, DSPP, BMP2, NOG
43actinomycin d448.8HIF1A, TGFB1, BMP2, SETD2
44vegf448.8NOG, TNFRSF11B, SP7, HIF1A, BMP2, SETD2
45atp44 289.5GUK1, HIF1A, SETD2, PLCB4, ENPP1, TNFRSF11B
46lipid448.5TNFRSF11B, ENPP1, SETD2, PLCB4, BMP2, GUK1
47dexamethasone44 50 28 1111.1DSPP, NOG, PLCB4, BMP2, ENPP1, TGFB1
48tyrosine447.9GDF5, GUK1, TNFRSF11B, HIF1A, ENPP1, PLCB4
49calcium44 50 24 1110.9BMP2, NOG, ANKH, SP7, DSPP, GUK1
50serine447.2SLC20A2, GUK1, TNFRSF11B, ENPP1, NOG, PLCB4

GO Terms for genes affiliated with Ankylosis

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Cellular components related to Ankylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.5DSPP, TGFB1, TNFRSF11B
2extracellular spaceGO:0056158.0ENPP1, GDF5, GDF7, TNFRSF11B, TGFB1, BMP2
3extracellular regionGO:0055767.6GDF5, TNFRSF11B, TGFB1, HEBP1, DSPP, BMP2

Biological processes related to Ankylosis according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1inorganic diphosphate transportGO:03050510.3ANKH, ENPP1
2cellular response to BMP stimulusGO:07177310.2BMP2, NOG
3pericardium developmentGO:06003910.2BMP2, SETD2
4regulation of bone mineralizationGO:03050010.2ANKH, ENPP1
5negative regulation of mesenchymal cell apoptotic processGO:200105410.2GDF5, HIF1A
6osteoblast differentiationGO:00164910.1NOG, BMP2, SP7
7positive regulation of odontogenesisGO:04248210.1TGFB1, BMP2
8biomineral tissue developmentGO:03121410.1ENPP1, DSPP
9positive regulation of branching involved in ureteric bud morphogenesisGO:09019010.1TGFB1, NOG
10connective tissue replacement involved in inflammatory response wound healingGO:00224810.0HIF1A, TGFB1
11negative regulation of ossificationGO:03027910.0ENPP1, TGFB1
12phosphate-containing compound metabolic processGO:0067969.9TGFB1, ENPP1
13chondrocyte differentiationGO:0020629.9BMP2, TGFB1, GDF5
14positive regulation vascular endothelial growth factor productionGO:0105759.8TGFB1, HIF1A
15positive regulation of epithelial to mesenchymal transitionGO:0107189.8BMP2, TGFB1
16growthGO:0400079.8GDF5, GDF7, BMP2
17BMP signaling pathwayGO:0305099.8GDF7, BMP2, NOG
18face morphogenesisGO:0603259.8NOG, TGFB1
19positive regulation of neuron differentiationGO:0456669.8GDF5, GDF7, BMP2
20skeletal system developmentGO:0015019.7TNFRSF11B, DSPP, ANKH, BMP2, NOG
21pathway-restricted SMAD protein phosphorylationGO:0603899.6GDF7, TGFB1, BMP2
22positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.6BMP2, TGFB1, GDF7
23cartilage developmentGO:0512169.6NOG, DLX2, HIF1A
24response to hypoxiaGO:0016669.6HIF1A, TGFB1, BMP2
25epithelial to mesenchymal transitionGO:0018379.6NOG, BMP2, TGFB1, HIF1A
26embryonic cranial skeleton morphogenesisGO:0487019.6SETD2, DLX2
27positive regulation of bone mineralizationGO:0305019.5BMP2, TGFB1
28extracellular matrix organizationGO:0301989.4GDF5, TNFRSF11B, TGFB1, DSPP, BMP2
29positive regulation of transcription, DNA-templatedGO:0458939.0GDF7, HIF1A, TGFB1, BMP2
30negative regulation of transcription from RNA polymerase II promoterGO:0001228.8NOG, DLX2, BMP2, TGFB1
31positive regulation of transcription from RNA polymerase II promoterGO:0459448.7SP7, HIF1A, TGFB1, BMP2, DLX2, NOG

Molecular functions related to Ankylosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inorganic phosphate transmembrane transporter activityGO:00531510.0SLC20A2, ANKH
2growth factor activityGO:0080838.9BMP2, TGFB1, GDF7, GDF5
3cytokine activityGO:0051258.8GDF5, GDF7, TNFRSF11B, BMP2

Products for genes affiliated with Ankylosis

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Sources for Ankylosis

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25ICD10
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