MCID: AND001
MIFTS: 48

Anodontia malady

Gastrointestinal diseases, Oral diseases categories

Summaries for Anodontia

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Sources:
63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 In dentistry, anodontia, also called anodontia vera, is a rare genetic disorder characterized by the... more...

MalaCards: Anodontia, also known as total anodontia of permanent and deciduous teeth, is related to hypohidrotic ectodermal dysplasia and hypotrichosis, and has symptoms including autosomal recessive inheritanceand anodontia/oligodontia/hypodontia. An important gene associated with Anodontia is AXIN2 (axin 2), and among its related pathways are Pathways in cancer and Endometrial cancer. The compound serine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Description from OMIM:46 206780

Aliases & Classifications for Anodontia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 46OMIM, 56SNOMED-CT, 60UMLS, 27ICD9CM, 34MeSH, 57SNOMED-CT via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Oral diseases


Aliases & Descriptions:

anodontia 8 42 48 46
total anodontia of permanent and deciduous teeth 8
anodontia of permanent dentition 42
developmental absence of tooth 8
absence of permanent teeth 42
complete absence of teeth 8
anodontia nos 8


External Ids:

Disease Ontology8 DOID:13714
ICD9CM27 520.0
OMIM46 206780
MeSH34 D000848
SNOMED-CT via Orphanet57 16958000, 26624006
MESH via Orphanet35 D000848
ICD10 via Orphanet26 K00.0
ICD1025 K00.0

Related Diseases for Anodontia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anodontia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1hypohidrotic ectodermal dysplasia30.4IKBKG, EDARADD
2hypotrichosis10.2
3aloi tomasini isaia syndrome10.1
4brachymetapody anodontia hypotrichosis albinoidism10.1
5epidermolysis bullosa simplex with anodontia/hypodontia10.1
6ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.0
7tooth agenesis, selective, 1, with or without orofacial cleft10.0
8microphthalmia10.0IKBKG
9ectodermal dysplasia10.0IKBKG
10tooth agenesis10.0AXIN2, EDARADD
11pol iii-related leukodystrophies10.0
12oto-palato-digital syndrome type 110.0
13ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.0
14oculoosteocutaneous syndrome10.0
15smith-lemli-opitz syndrome9.8
16johanson-blizzard syndrome9.8
17bloom syndrome9.8
18rothmund-thomson syndrome9.8
19cherubism9.8
20ankylosis9.8
21williams-beuren syndrome9.8
22epidermolysis bullosa simplex9.8
23kbg syndrome9.8
24type i ehlers-danlos syndrome9.8
25autosomal dominant microcephaly9.8
26weaver syndrome9.8
27ladd syndrome9.8
28papillon-lefevre disease9.8
29ellis-van creveld syndrome9.8
30anhidrosis9.8
31wolf-hirschhorn syndrome9.8
32branchiooculofacial syndrome9.8
33focal dermal hypoplasia9.8
34oculocerebrorenal syndrome9.8
35laron syndrome9.8
36cleft lip9.8
37waardenburg's syndrome9.8
38tooth ankylosis9.8
39beare-stevenson cutis gyrata syndrome9.8
40progeria9.8
41bloch-sulzberger syndrome9.8
42coffin-lowry syndrome9.8
43alopecia9.8
44epidermolysis bullosa9.8
45optic atrophy9.8
46smith magenis syndrome9.8
47ankyloblepharon-ectodermal defects-cleft lip/palate syndrome9.8
48char syndrome9.8
49cohen syndrome9.8
50congenital deafness with labyrinthine aplasia, microtia, and microdontia9.8

Graphical network of the top 20 diseases related to Anodontia:



Diseases related to anodontia

Clinical Features for Anodontia

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

206780

Clinical synopsis from OMIM:

206780

Symptoms:

48
  • autosomal recessive inheritance
  • anodontia/oligodontia/hypodontia

Drugs & Therapeutics for Anodontia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Anodontia

Search NIH Clinical Center for Anodontia

Search CenterWatch for Anodontia

Genetic Tests for Anodontia

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Anatomical Context for Anodontia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Anodontia:

32
Skin, Bone, Liver, Kidney

Animal Models for Anodontia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Anodontia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7AXIN2, PITX2, EDARADD
2MP:00053828.6AXIN2, PITX2, EDARADD
3MP:00028738.5PITX2, AXIN2, IKBKG
4MP:00053918.5EDARADD, PITX2, AXIN2
5MP:00053798.1EDARADD, PITX2, AXIN2, IKBKG
6MP:00053898.1AXIN2, IKBKG, PITX2, EDARADD
7MP:00107687.7IKBKG, AXIN2, PITX2, EDARADD

Publications for Anodontia

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Sources:
50PubMed
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Articles related to Anodontia:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Prosthetic rehabilitation of a preschooler with induced anodontia - A clinical report. (22090765)
2011
2
Prosthodontic rehabilitation of a patient with true partial anodontia - A case report. (23204727)
2010
3
Ectodermal dysplasia with anodontia: a report of two cases. (20396456)
2010
4
Congenital anodontia in ectodermal dysplasia. (19189682)
2008
5
Prosthodontic treatment of hypohidrotic ectodermal dysplasia with complete anodontia: case report. (17216912)
2007
6
Coexistent partial anodontia and supernumerary tooth in the mandibular arch: a rare case. (16891749)
2006
7
The use of colored elastomeric "O"s as a motivational instrument for patients with anodontia: report of case. (10431618)
1999
8
Craniofacial changes following early prosthetic treatment in a case of hypohidrotic ectodermal dysplasia with complete anodontia. (9617452)
1998
9
The use of magnets in the comprehensive treatment of congenital partial anodontia: a case report. (9477872)
1997
10
Oral rehabilitation of a patient with congenital partial anodontia using a rotational path removable partial denture: report of a case. (7568733)
1995
11
Prosthetic rehabilitation of a child with induced anodontia. (8634197)
1995
12
Anodontia associated with hypohidrotic ectodermal dysplasia. (1344283)
1992
13
Overdentures in partial anodontia: simple solutions for complex problems. (1860126)
1991
14
Anodontia and jaw dysplasia syndrome: an isolated, idiopathic aberration. (2097249)
1990
15
Anodontia as the sole clinical sign of the ectrodactyly-ectodermal dysplasia-cleft lip (EEC) syndrome. (2222925)
1990
16
Prosthetic management of hypohydrotic ectodermal dysplasia with anodontia. Case report. (2346400)
1990
17
Familial medullary sponge kidney in association with congenital absence of teeth (anodontia). (3352850)
1988
18
Ectodermal dysplasia with partial anodontia: prosthetic treatment with implant fixed prosthesis. (3045169)
1988
19
Use of an etched metal resin-bonded retainer in a patient with partial anodontia. (7045752)
1982
20
Case history on anodontia. (6962306)
1982
21
A genetic study of anodontia in X-linked hypohidrotic ectodermal dysplasia. (7446529)
1980
22
Articulation implications in a case of anhidrotic ectodermal dysplasia and partial anodontia. (283082)
1979
23
The oral rehabilitation of a severe case of partial anodontia. (287684)
1979
24
Anodontia vacationala. (298243)
1979
25
Is partial anodontia a syndrome of Black Americans? (272136)
1978
26
Unusual partial anodontia. (1062759)
1976
27
Anodontia. (1018144)
1976
28
Familial partial anodontia: report of a case. (4587850)
1974
29
Anodontia. A case report. (4531314)
1974
30
Restorative dentistry applied to partial anodontia--case report. (4530007)
1974
31
Anodontia associated with hypohidrotic ectodermal dysplasia. A case report. (4529381)
1974
32
Multiple anodontia. (4529246)
1974
33
A case of partial anodontia in a dog. (5035031)
1972
34
Anodontia of all bicuspids. (4505971)
1972
35
The form of the dentition in partial anodontia. (5263162)
1970
36
A clinical and genetical investigation of partial anodontia with special reference to anodontia involving upper lateral incisors. (5268841)
1970
37
Anodontia in a cat. (5812902)
1969
38
Dentures for anodontia cases. (4882517)
1968
39
Anodontia in mongolism. (4223451)
1966
40
OCCLUSAL REHABILITATION OF A CASE EXHIBITING MARKED ATTRITION, PARTIAL ANODONTIA, AND EXCESSIVE MANDIBULAR CLOSURE. (14280358)
1965
41
PARTIAL ANODONTIA VERA. (14292510)
1965
42
Muscle and skull developmental changes in dogs with induced unilateral anodontia. (5213237)
1965
43
Anodontia--two cases of different etiology. (13990061)
1963
44
Fourteen-year report of facial growth in case of complete anodontia with ectodermal dysplasia. (13079284)
1953
45
Partial anodontia; a brief review and a case report of multiple familial incidence. (15400394)
1950
46
A pedigree of partial anodontia. (18137065)
1949
47
Anodontia in a child; report of a case. (18132158)
1949
48
An interesting case of partial anodontia. (18918912)
1947
49
Partial anodontia; congenital absence of permanent canines. (20253257)
1947
50
Case report of complete anodontia of the permanent teeth. (20272163)
1947

Genetic Variations for Anodontia

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Expression for genes affiliated with Anodontia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anodontia

Search GEO for disease gene expression data for Anodontia.

Pathways for genes affiliated with Anodontia

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Sources:
29KEGG, 37NCBI BioSystems Database
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Pathways related to Anodontia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3IKBKG, AXIN2
2
Hide members
9.3IKBKG, AXIN2
39.1AXIN2, PITX2

Compounds for genes affiliated with Anodontia

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44Novoseek
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Compounds related to Anodontia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine448.5IKBKG, AXIN2, PITX2

GO Terms for genes affiliated with Anodontia

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16Gene Ontology
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Cellular components related to Anodontia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.0IKBKG, AXIN2, PITX2, EDARADD

Biological processes related to Anodontia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1odontogenesis of dentin-containing toothGO:0424759.1PITX2, EDARADD
2odontogenesisGO:0424768.8AXIN2, PITX2

Molecular functions related to Anodontia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transducer activityGO:0048719.3IKBKG, AXIN2

Products for genes affiliated with Anodontia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anodontia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet