MCID: AND001
MIFTS: 46

Anodontia

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Anodontia

MalaCards integrated aliases for Anodontia:

Name: Anodontia 12 72 49 28 14
Total Anodontia of Permanent and Deciduous Teeth 12
Anodontia of Permanent Dentition 49
Developmental Absence of Tooth 12
Absence of Permanent Teeth 49
Complete Absence of Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13714
ICD10 32 K00.0
ICD9CM 34 520.0
MeSH 41 D000848
UMLS 69 C0399352

Summaries for Anodontia

NIH Rare Diseases : 49 Anodontia is a dental condition characterized by complete absence of teeth. The primary (baby) or permanent (adult) teeth may be involved. Anodontia is extremely rare when present in a pure form (without associated abnormalities). In most cases, the phenomenon is associated with a group of conditions called the ectodermal dysplasias. In these cases, abnormalities are also noted in the hair, nails, and sweat glands. Anodontia is an autosomal recessive condition. A specific gene has not yet been identified. Treatment involves replacement of the teeth with dentures or implants. Last updated: 10/7/2015

MalaCards based summary : Anodontia, also known as total anodontia of permanent and deciduous teeth, is related to ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive and ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive. An important gene associated with Anodontia is PAX9 (Paired Box 9), and among its related pathways/superpathways are Neural Crest Differentiation and Wnt / Hedgehog / Notch. The drugs Ibuprofen and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and kidney, and related phenotypes are craniofacial and endocrine/exocrine gland

Wikipedia : 72 In dentistry, anodontia, also called anodontia vera, is a rare genetic disorder characterized by the... more...

Related Diseases for Anodontia

Diseases related to Anodontia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 31.2 EDA EDARADD
2 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 30.8 EDA EDARADD MSX1 PAX9
3 ectodermal dysplasia 30.5 EDA EDARADD
4 tooth agenesis 30.2 AXIN2 EDA EDARADD MSX1 PAX9
5 hypotrichosis 29.7 EDA EDARADD
6 cleft lip 29.5 MSX1 PAX9
7 anodontia of permanent dentition 12.3
8 brachymetapody-anodontia-hypotrichosis-albinoidism 12.0
9 epidermolysis bullosa simplex with anodontia/hypodontia 11.9
10 aloi tomasini isaia syndrome 11.5
11 late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 11.2
12 ectodermal dysplasia 1, hypohidrotic, x-linked 11.2
13 tooth agenesis, selective, 1 10.9
14 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.9
15 cleft lip/palate-ectodermal dysplasia syndrome 10.9
16 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.9
17 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 10.9
18 zlotogora syndrome 10.9
19 tooth size 10.1 MSX1 PAX9
20 mouth disease 10.0 MSX1 PAX9
21 cleft palate, isolated 9.9 MSX1 PAX9
22 hypohidrosis 9.9 EDA EDARADD
23 sweat gland disease 9.9 EDA EDARADD
24 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 9.8
25 teeth, supernumerary 9.8
26 gapo syndrome 9.8
27 rothmund-thomson syndrome 9.8
28 incontinentia pigmenti 9.8
29 erythrokeratodermia variabilis et progressiva 5 9.8
30 alopecia 9.8
31 anhidrosis 9.8
32 ankylosis 9.8
33 epidermolysis bullosa 9.8
34 epidermolysis bullosa simplex 9.8
35 waardenburg's syndrome 9.8
36 medullary sponge kidney 9.8
37 orofacial cleft 9.7 MSX1 PAX9
38 clouston syndrome 9.6 ANTXR1 EDA EDARADD
39 fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly 9.0 AXIN2 EDARADD MSX1 PAX9

Graphical network of the top 20 diseases related to Anodontia:



Diseases related to Anodontia

Symptoms & Phenotypes for Anodontia

Human phenotypes related to Anodontia:

31
# Description HPO Frequency HPO Source Accession
1 anodontia 31 hallmark (90%) HP:0000674

MGI Mouse Phenotypes related to Anodontia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.65 ANTXR1 AXIN2 EDARADD MSX1 PAX9
2 endocrine/exocrine gland MP:0005379 9.55 ANTXR1 AXIN2 EDARADD MSX1 PAX9
3 limbs/digits/tail MP:0005371 9.26 AXIN2 EDARADD MSX1 PAX9
4 skeleton MP:0005390 9.02 ANTXR1 AXIN2 EDARADD MSX1 PAX9

Drugs & Therapeutics for Anodontia

Drugs for Anodontia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 4 15687-27-1 3672
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Menthol Approved Phase 4 2216-51-5 16666
4 Acetaminophen, hydrocodone drug combination Phase 4
5 Pharmaceutical Solutions Phase 4
6
Cobalt Phase 1, Phase 2 7440-48-4 104729
7 Micronutrients Phase 1, Phase 2
8 Trace Elements Phase 1, Phase 2
9 Tea Nutraceutical Phase 2
10
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
11
Flurbiprofen Approved, Investigational Early Phase 1 5104-49-4 3394
12
Cimetidine Approved, Investigational 51481-61-9 2756
13
Histamine Approved, Investigational 51-45-6, 75614-87-8 774
14 Mitogens
15 Calcium, Dietary
16 Analgesics Early Phase 1
17 Analgesics, Non-Narcotic Early Phase 1
18 Peripheral Nervous System Agents Early Phase 1
19 Anti-Infective Agents
20 Anti-Infective Agents, Local
21 Anti-Inflammatory Agents Early Phase 1
22 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
23 Antirheumatic Agents Early Phase 1
24 Carbon fiber
25 Lithium carbonate 554-13-2
26 Central Nervous System Depressants
27 Tranquilizing Agents
28 Antidepressive Agents
29 Antimanic Agents
30 Psychotropic Drugs
31 Cyclooxygenase Inhibitors Early Phase 1
32
Histamine Phosphate 51-74-1 65513
33 Gastrointestinal Agents
34 Neurotransmitter Agents
35 Histamine Antagonists
36 Histamine H2 Antagonists
37 Cytochrome P-450 CYP1A2 Inhibitors
38 Cytochrome P-450 Enzyme Inhibitors
39 Antacids
40 Anti-Ulcer Agents

Interventional clinical trials:

(show top 50) (show all 63)

# Name Status NCT ID Phase Drugs
1 Guided Bone Regeneration Around Immediate Implants Completed NCT01628367 Phase 4 Medications
2 The Influence of Dimensional Anatomic Variables on the Outcomes of Maxillary Sinus Grafting Procedures Completed NCT00868777 Phase 4
3 Peri-implant Bone Changes in Post-menopausal Osteoporotic Women Recruiting NCT02884401 Phase 4
4 TM vs TSV Implants Loaded Early vs Conventional in Anterior and Posterior Areas Recruiting NCT02158377 Phase 4
5 Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3 InductOs
6 Alveolar Ridge Preservation With Polycaprolactone Scaffold for Implant Site Development Unknown status NCT00466414 Phase 2
7 Risk Factors for Implant Bone Loss in Patients With Diabetes Mellitus Completed NCT00933491 Phase 2
8 Interventions for Patients With a Shortened Dental Arch Completed NCT01597206 Phase 1, Phase 2
9 Clinical and Radiographic Evaluation of Crestal Bone Loss Around Implant With or Without Platform Switching Design Completed NCT02761226 Phase 2
10 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2 Lozenge Intake
11 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
12 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
13 Hypodontia and Ovarian Cancer Unknown status NCT01470235
14 "Prospective Evaluation of Immediate & Early Loading of Zimmer Hydroxyapatite Coated Dental Implants" Unknown status NCT02397044
15 Clinical Study on Zirconia Bridges Unknown status NCT01835834
16 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
17 Randomized Controlled Clinical Trial of CAD/CAM and Conventionally Fabricated Singl Implant Abutments. Unknown status NCT01229995
18 Vertical Augmentation With Osteon at Dental Implant Placement Unknown status NCT01162629
19 Stability of Implants With Different Surface Treatment: Randomized Clinical Trial Unknown status NCT01699568
20 Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries Unknown status NCT02056262
21 OHQoL With Removable Partial Dentures; a Pilot Study Completed NCT01953991
22 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420
23 Radiographic and the Esthetic Outcome of Two Different Bone Grafting Techniques in Early Implant Placement Completed NCT03302143
24 Effect of Implant Thread Design on Implant Stability Quotient (ISQ) in Early Healing Period Completed NCT02701387
25 Chewing Side Preference and Hemispheric Laterality in Healthy Adults Completed NCT03054246
26 An Assessment of Bone Augmentation in Post-Extraction Sockets Completed NCT00641316
27 Longitudinal Efficacy of Dental Implants in Anterior Areas Completed NCT00641277
28 Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement Completed NCT01603693
29 Clinical Study of Oral Endosseous Titanium Implants in Edentulous Subjects Completed NCT00001211
30 Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft Completed NCT01924390
31 Evaluation of the ACE Dental Implant Completed NCT00641576
32 Electromyographic Estimation of Neuro-muscular Coordination of Masticatory Muscles in Patients Treated With Implants (D-2012-057) Completed NCT03415971
33 Oral Health and People With Systemic Sclerosis Completed NCT01817361
34 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Recruiting NCT02239718
35 One-Tooth One-Time (1T1T) A Straightforward Approach to Replace Missing Teeth in the Posterior Region: a Case Series Recruiting NCT02898311
36 A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials. Recruiting NCT03059914
37 REFRAME RPD Post-Market Clinical Study Recruiting NCT03198520
38 Long Term Dental Effects in Adolescents Who Were Treated for Cancer in Childhood Recruiting NCT02742363
39 Frequency of Hypodontia After Chemotherapy in Childhood Cancer Survivors Study Recruiting NCT03445026
40 Temporary Anchorage Devices for Ridge Preservation Recruiting NCT03205800
41 Efficacy of Er:YAG Laser in Decontamination of Dental Implants: An In-Vitro Study Recruiting NCT03100435
42 Oral Health for Healthy Cognitive Aging Recruiting NCT02986386
43 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
44 The Effect of Platform-Matching Versus Platform-Switching Dental Implants on Peri-implant Hard and Soft Tissue Healing Active, not recruiting NCT02536716
45 Lithium Disilicate (CAD/CAM) Fixed Partial Dentures (FPD) Clinical Study Active, not recruiting NCT03036566
46 The Clinical Performance of Inlay Zirconia Bridges Active, not recruiting NCT02995876
47 Esthetic Outcomes of Immediately Placed Implants Receiving Immediate Provisionalization and Delayed Restoration Active, not recruiting NCT01925339
48 Survival and Success of MIS C1 Implants- a Field Study Active, not recruiting NCT01707108
49 Clinical Assessment of Dental Implant Active, not recruiting NCT02591706
50 Guided Surgery Versus Sinus Graft Active, not recruiting NCT01988480

Search NIH Clinical Center for Anodontia

Genetic Tests for Anodontia

Genetic tests related to Anodontia:

# Genetic test Affiliating Genes
1 Anodontia 28

Anatomical Context for Anodontia

MalaCards organs/tissues related to Anodontia:

38
Bone, Skin, Kidney, Liver

Publications for Anodontia

Articles related to Anodontia:

(show top 50) (show all 114)
# Title Authors Year
1
"Maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin. ( 29364376 )
2017
2
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. ( 26759063 )
2016
3
Early functional, esthetic, and psychological rehabilitation of preschool child with nonsyndromic oligodontia and anodontia in mixed dentition stage through conservative systematic approach: A case report with 5-year follow-up. ( 27307674 )
2016
4
Dental management of Rothmund-Thomson syndrome with partial anodontia. ( 26032705 )
2015
5
Prosthodontic management of hypohidrotic ectodermal dysplasia with anodontia: a case report in pediatric patient and review of literature. ( 23919206 )
2013
6
PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China. ( 23857653 )
2013
7
Prosthetic rehabilitation of a child suffering from hypohidrotic ectodermal dysplasia with complete anodontia. ( 25206157 )
2012
8
Prosthetic rehabilitation of a preschooler with induced anodontia - A clinical report. ( 22090765 )
2011
9
Total anodontia in patient with hypohidrotic ectodermal dysplasia. Report of rare case of Christ-Siemens Touraine syndrome. ( 21417166 )
2011
10
Ectodermal dysplasia with true anodontia. ( 22529591 )
2011
11
Prosthodontic rehabilitation of a patient with true partial anodontia - A case report. ( 23204727 )
2010
12
Ectodermal dysplasia with anodontia: a report of two cases. ( 20396456 )
2010
13
Congenital oligodontia of the deciduous teeth and anodontia of the permanent teeth in a cat. ( 18835802 )
2009
14
Congenital anodontia in ectodermal dysplasia. ( 19189682 )
2008
15
Prosthetic rehabilitation of an adolescent with hypohidrotic ectodermal dysplasia with partial anodontia: case report. ( 19008629 )
2008
16
Congenital hypotrichosis and partial anodontia in a crossbred beef calf. ( 17616058 )
2007
17
Prosthodontic treatment of hypohidrotic ectodermal dysplasia with complete anodontia: case report. ( 17216912 )
2007
18
Hypohidrotic ectodermal dysplasia with true anodontia of the primary dentition. ( 18197325 )
2007
19
Coexistent partial anodontia and supernumerary tooth in the mandibular arch: a rare case. ( 16891749 )
2006
20
Ectodermal dysplasia with total anodontia: rehabilitation of a seven year old child. ( 12435010 )
2002
21
Congenital hypotrichosis with anodontia in cattle: a genetic, clinical and histological analysis. ( 12464063 )
2002
22
Prosthodontic rehabilitation of a patient with partial anodontia: a clinical report. ( 12397238 )
2002
23
Clinical management of hypohidrotic ectodermal dysplasia with anodontia: case report. ( 12413164 )
2002
24
A rare non-syndrome case of concomitant multiple supernumerary teeth and partial anodontia. ( 11314218 )
2001
25
Oxygen, sulphide and nutrient uptake of the mangrove mud clam Anodontia edentula (Family: Lucinidae). ( 11763226 )
2001
26
Anodontia with hypohidrotic ectodermal dysplasia in a young female: a case report. ( 10730287 )
2000
27
Partial anodontia in a case of Waardenburg's syndrome. ( 10605569 )
1999
28
The use of colored elastomeric "O"s as a motivational instrument for patients with anodontia: report of case. ( 10431618 )
1999
29
Implant-supported prosthesis in a child with hereditary mandibular anodontia: the use of ball attachments. ( 9558550 )
1998
30
Craniofacial changes following early prosthetic treatment in a case of hypohidrotic ectodermal dysplasia with complete anodontia. ( 9617452 )
1998
31
Primary tuberculous liver abscess associated with progressive symmetric erythrokeratodermia, anodontia and ectodermal dysplasias. ( 9828554 )
1998
32
The use of magnets in the comprehensive treatment of congenital partial anodontia: a case report. ( 9477872 )
1997
33
Oral rehabilitation of a patient with congenital partial anodontia using a rotational path removable partial denture: report of a case. ( 7568733 )
1995
34
Prosthetic rehabilitation of a child with induced anodontia. ( 8634197 )
1995
35
Treating severe partial anodontia: a 10-year history of patient treatment. ( 7798481 )
1994
36
Anodontia associated with hypohidrotic ectodermal dysplasia. ( 1344283 )
1992
37
Dentocraniofacial structure with complete anodontia of permanent teeth: report of case. ( 1629447 )
1992
38
Overdentures in partial anodontia: simple solutions for complex problems. ( 1860126 )
1991
39
Complete anodontia of the permanent dentition: case report. ( 2133936 )
1990
40
Anodontia and jaw dysplasia syndrome: an isolated, idiopathic aberration. ( 2097249 )
1990
41
Anodontia of the permanent dentition: fourteen years after initial diagnosis. ( 2319058 )
1990
42
Prosthetic management of hypohydrotic ectodermal dysplasia with anodontia. Case report. ( 2346400 )
1990
43
Anodontia as the sole clinical sign of the ectrodactyly-ectodermal dysplasia-cleft lip (EEC) syndrome. ( 2222925 )
1990
44
Partial anodontia: a case report. ( 2598201 )
1989
45
Unilateral linear basal cell nevus associated with diffuse osteoma cutis, unilateral anodontia, and abnormal bone mineralization. ( 2715453 )
1989
46
Congenital partial anodontia: prosthodontic considerations. ( 3250573 )
1988
47
A genetic, pathological and virological study of congenital hypotrichosis and incisor anodontia in cattle. ( 2836985 )
1988
48
Ectodermal dysplasia with partial anodontia: prosthetic treatment with implant fixed prosthesis. ( 3045169 )
1988
49
Anodontia totalis fetalis in a trisomy 13 mosaic. ( 3272969 )
1988
50
Familial medullary sponge kidney in association with congenital absence of teeth (anodontia). ( 3352850 )
1988

Variations for Anodontia

Expression for Anodontia

Search GEO for disease gene expression data for Anodontia.

Pathways for Anodontia

Pathways related to Anodontia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 AXIN2 MSX1
2 11.06 AXIN2 MSX1 PAX9
3
Show member pathways
10.87 EDA EDARADD

GO Terms for Anodontia

Biological processes related to Anodontia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.55 AXIN2 EDA EDARADD MSX1 PAX9
2 positive regulation of canonical Wnt signaling pathway GO:0090263 9.4 AXIN2 EDA
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.37 EDA EDARADD
4 odontogenesis of dentin-containing tooth GO:0042475 9.32 EDA MSX1
5 face morphogenesis GO:0060325 9.26 MSX1 PAX9
6 regulation of odontogenesis GO:0042481 8.96 MSX1 PAX9
7 odontogenesis GO:0042476 8.8 AXIN2 MSX1 PAX9

Molecular functions related to Anodontia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 8.62 MSX1 PAX9

Sources for Anodontia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....