MCID: AND001
MIFTS: 44

Anodontia malady

Gastrointestinal, Oral categories

Summaries for Anodontia

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 In dentistry, anodontia, also called anodontia vera, is a rare genetic disorder characterized by the... more...

MalaCards: Anodontia, also known as total anodontia of permanent and deciduous teeth, is related to ectodermal dysplasia and hypohidrotic ectodermal dysplasia, and has symptoms including autosomal recessive inheritanceand anodontia/oligodontia/hypodontia. An important gene associated with Anodontia is AXIN2 (axin 2), and among its related pathways are Pathways in cancer and Endometrial cancer. The compound serine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are limbs/digits/tail and craniofacial.

Description from OMIM:47 206780

Aliases & Classifications for Anodontia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 47OMIM, 57SNOMED-CT, 61UMLS, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Oral


Aliases & Descriptions:

anodontia 8 43 49 47
total anodontia of permanent and deciduous teeth 8
anodontia of permanent dentition 43
developmental absence of tooth 8
absence of permanent teeth 43
complete absence of teeth 8
anodontia nos 8


External Ids:

Disease Ontology8 DOID:13714
ICD9CM27 520.0
OMIM47 206780
MeSH35 D000848
MESH via Orphanet36 D000848
ICD10 via Orphanet26 K00.0
SNOMED-CT via Orphanet58 26624006
ICD1025 K00.0

Related Diseases for Anodontia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Anodontia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1ectodermal dysplasia30.8IKBKG
2hypohidrotic ectodermal dysplasia30.5EDARADD, IKBKG
3aloi tomasini isaia syndrome10.1
4brachymetapody anodontia hypotrichosis albinoidism10.1
5ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant10.1
6epidermolysis bullosa simplex with anodontia/hypodontia10.1
7microphthalmia10.0IKBKG
8oto-palato-digital syndrome type 110.0
9ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive10.0
10tooth agenesis, selective, 1, with or without orofacial cleft10.0
11oculoosteocutaneous syndrome10.0
12tooth agenesis10.0AXIN2, EDARADD
13smith-lemli-opitz syndrome9.8
14johanson-blizzard syndrome9.8
15bloom syndrome9.8
16rothmund-thomson syndrome9.8
17cherubism9.8
18ankylosis9.8
19williams-beuren syndrome9.8
20epidermolysis bullosa simplex9.8
21kbg syndrome9.8
22type i ehlers-danlos syndrome9.8
23autosomal dominant microcephaly9.8
24weaver syndrome9.8
25ladd syndrome9.8
26papillon-lefevre disease9.8
27ellis-van creveld syndrome9.8
28anhidrosis9.8
29wolf-hirschhorn syndrome9.8
30branchiooculofacial syndrome9.8
31focal dermal hypoplasia9.8
32oculocerebrorenal syndrome9.8
33laron syndrome9.8
34waardenburg's syndrome9.8
35tooth ankylosis9.8
36beare-stevenson cutis gyrata syndrome9.8
37progeria9.8
38n syndrome9.8
39bloch-sulzberger syndrome9.8
40coffin-lowry syndrome9.8
41alopecia9.8
42smith magenis syndrome9.8
43ankyloblepharon-ectodermal defects-cleft lip/palate syndrome9.8
44char syndrome9.8
45cohen syndrome9.8
46congenital deafness with labyrinthine aplasia, microtia, and microdontia9.8
47oral-facial-digital syndrome type i9.8
48moebius syndrome9.8
49acrofacial dysostosis catania type9.8
50weyers acrofacial dysostosis9.8

Graphical network of the top 20 diseases related to Anodontia:



Diseases related to anodontia

Clinical Features for Anodontia

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

206780

Clinical synopsis from OMIM:

206780

Symptoms:

49
  • autosomal recessive inheritance
  • anodontia/oligodontia/hypodontia

Drugs & Therapeutics for Anodontia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Anodontia

Drug clinical trials:

Search ClinicalTrials for Anodontia

Search NIH Clinical Center for Anodontia

Search CenterWatch for Anodontia

Genetic Tests for Anodontia

Anatomical Context for Anodontia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anodontia:

33
Skin, Liver, Kidney

Animal Models for Anodontia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Anodontia

Sources:
51PubMed
See all sources

Articles related to Anodontia:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Prosthodontic management of hypohidrotic ectodermal dysplasia with anodontia: a case report in pediatric patient and review of literature. (23919206)
2013
2
PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China. (23857653)
2013
3
Ectodermal dysplasia with true anodontia. (22529591)
2011
4
Prosthetic rehabilitation of a preschooler with induced anodontia - A clinical report. (22090765)
2011
5
Congenital anodontia in ectodermal dysplasia. (19189682)
2008
6
Prosthetic rehabilitation of an adolescent with hypohidrotic ectodermal dysplasia with partial anodontia: case report. (19008629)
2008
7
Prosthodontic treatment of hypohidrotic ectodermal dysplasia with complete anodontia: case report. (17216912)
2007
8
Congenital hypotrichosis with anodontia in cattle: a genetic, clinical and histological analysis. (12464063)
2002
9
Prosthodontic rehabilitation of a patient with partial anodontia: a clinical report. (12397238)
2002
10
Clinical management of hypohidrotic ectodermal dysplasia with anodontia: case report. (12413164)
2002
11
A rare non-syndrome case of concomitant multiple supernumerary teeth and partial anodontia. (11314218)
2001
12
Oxygen, sulphide and nutrient uptake of the mangrove mud clam Anodontia edentula (Family: Lucinidae). (11763226)
2001
13
Craniofacial changes following early prosthetic treatment in a case of hypohidrotic ectodermal dysplasia with complete anodontia. (9617452)
1998
14
Treating severe partial anodontia: a 10-year history of patient treatment. (7798481)
1994
15
Dentocraniofacial structure with complete anodontia of permanent teeth: report of case. (1629447)
1992
16
Anodontia and jaw dysplasia syndrome: an isolated, idiopathic aberration. (2097249)
1990
17
Complete anodontia of the permanent dentition: case report. (2133936)
1990
18
Anodontia as the sole clinical sign of the ectrodactyly-ectodermal dysplasia-cleft lip (EEC) syndrome. (2222925)
1990
19
Prosthetic management of hypohydrotic ectodermal dysplasia with anodontia. Case report. (2346400)
1990
20
Partial anodontia: a case report. (2598201)
1989
21
Ectodermal dysplasia with partial anodontia: prosthetic treatment with implant fixed prosthesis. (3045169)
1988
22
Growth retardation, alopecia, pseudo-anodontia, and optic atrophy--the GAPO syndrome: report of a patient and review of the literature. (6507471)
1984
23
Use of an etched metal resin-bonded retainer in a patient with partial anodontia. (7045752)
1982
24
A genetic study of anodontia in X-linked hypohidrotic ectodermal dysplasia. (7446529)
1980
25
Articulation implications in a case of anhidrotic ectodermal dysplasia and partial anodontia. (283082)
1979
26
The oral rehabilitation of a severe case of partial anodontia. (287684)
1979
27
Dento-facial correction of partial anodontia. (282512)
1979
28
Anodontia vacationala. (298243)
1979
29
Articulation implications in a case of anhidrotic ectodermal dysplasia and partial anodontia. (279567)
1978
30
Unusual partial anodontia. (1062759)
1976
31
Anodontia. (1018144)
1976
32
Familial partial anodontia: report of a case. (4587850)
1974
33
Restorative dentistry applied to partial anodontia--case report. (4530007)
1974
34
Anodontia associated with hypohidrotic ectodermal dysplasia. A case report. (4529381)
1974
35
Anodontia of all bicuspids. (4505971)
1972
36
The form of the dentition in partial anodontia. (5263162)
1970
37
A clinical and genetical investigation of partial anodontia with special reference to anodontia involving upper lateral incisors. (5268841)
1970
38
Anodontia in a cat. (5812902)
1969
39
Dentures for anodontia cases. (4882517)
1968
40
Partial anodontia in incontinentia pigmenti. (5224626)
1966
41
Anodontia in mongolism. (4223451)
1966
42
TOTAL ANODONTIA WITH ECTODERMAL DYSPLASIA. (14300058)
1965
43
Total anodontia with ectodermal dysplasia. (5213145)
1965
44
PARTIAL ANODONTIA VERA. (14292510)
1965
45
Anodontia--two cases of different etiology. (13990061)
1963
46
Anhidrotic ectodermal dysplasia with anodontia: a study of two families. (14888436)
1952
47
Partial anodontia; a brief review and a case report of multiple familial incidence. (15400394)
1950
48
Anodontia in hereditary ectodermal dysplasia. (18129730)
1949
49
Anodontia in a child; report of a case. (18132158)
1949
50
An interesting case of partial anodontia. (18918912)
1947

Genetic Variations for Anodontia

Expression for genes affiliated with Anodontia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anodontia

Search GEO for disease gene expression data for Anodontia.

Pathways for genes affiliated with Anodontia

Sources:
30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Anodontia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3IKBKG, AXIN2
2
Hide members
9.3IKBKG, AXIN2
39.1AXIN2, PITX2

Compounds for genes affiliated with Anodontia

Sources:
45Novoseek
See all sources

Compounds related to Anodontia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1serine458.5IKBKG, AXIN2, PITX2

GO Terms for genes affiliated with Anodontia

Sources:
16Gene Ontology
See all sources

Cellular components related to Anodontia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.0IKBKG, AXIN2, PITX2, EDARADD

Biological processes related to Anodontia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1odontogenesis of dentin-containing toothGO:0424759.1PITX2, EDARADD
2odontogenesisGO:0424768.8AXIN2, PITX2

Molecular functions related to Anodontia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transducer activityGO:0048719.3IKBKG, AXIN2

Products for genes affiliated with Anodontia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anodontia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet