MCID: AND001
MIFTS: 43

Anodontia malady

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Anodontia

Aliases & Descriptions for Anodontia:

Name: Anodontia 12 50 29 14
Total Anodontia of Permanent and Deciduous Teeth 12
Anodontia of Permanent Dentition 50
Developmental Absence of Tooth 12
Absence of Permanent Teeth 50
Complete Absence of Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13714
ICD10 33 K00.0
ICD9CM 35 520.0
MeSH 42 D000848
UMLS 69 C0399352

Summaries for Anodontia

NIH Rare Diseases : 50 anodontia is a dental condition characterized by complete absence of teeth. the primary (baby) or permanent (adult) teeth may be involved. anodontia is extremely rare when present in a pure form (without associated abnormalities). in most cases, the phenomenon is associated with a group of conditions called the ectodermal dysplasias. in these cases, abnormalities are also noted in the hair, nails, and sweat glands. anodontia is an autosomal recessive condition. a specific gene has not yet been identified. treatment involves replacement of the teeth with dentures or implants. last updated: 10/7/2015

MalaCards based summary : Anodontia, also known as total anodontia of permanent and deciduous teeth, is related to anodontia of permanent dentition and brachymetapody-anodontia-hypotrichosis-albinoidism. An important gene associated with Anodontia is PAX9 (Paired Box 9), and among its related pathways/superpathways are Neural Crest Differentiation and Wnt / Hedgehog / Notch. The drugs Ibuprofen and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related phenotypes are craniofacial and endocrine/exocrine gland

Wikipedia : 71 In dentistry, anodontia, also called anodontia vera, is a rare genetic disorder characterized by the... more...

Related Diseases for Anodontia

Diseases related to Anodontia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
id Related Disease Score Top Affiliating Genes
1 anodontia of permanent dentition 11.9
2 brachymetapody-anodontia-hypotrichosis-albinoidism 11.8
3 epidermolysis bullosa simplex with anodontia/hypodontia 11.8
4 tooth agenesis 11.3
5 aloi tomasini isaia syndrome 11.0
6 epidermolysis bullosa, late-onset localized junctional, with mental retardation 10.8
7 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.8
8 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 10.8
9 tooth agenesis, selective, 1, with or without orofacial cleft 10.8
10 cleft lip/palate-ectodermal dysplasia syndrome 10.8
11 ectodermal dysplasia 1, hypohidrotic, x-linked 10.8
12 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.8
13 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.8
14 ectodermal dysplasia 10.4
15 hypotrichosis 10.0
16 chronic ethmoiditis 10.0 MSX1 PAX9
17 cleft palate with ankyloglossia 10.0 EDA EDARADD
18 neonatal respiratory failure 9.9 EDA EDARADD
19 scleroperikeratitis 9.9 EDA EDARADD
20 fungal gastritis 9.9 MSX1 PAX9
21 end stage renal failure 9.9 EDA EDARADD
22 dementia, familial british 9.8 ANTXR1 EDA EDARADD
23 gapo syndrome 9.7
24 ankylosis 9.7
25 epidermolysis bullosa 9.7
26 epidermolysis bullosa simplex 9.7
27 rothmund-thomson syndrome 9.7
28 waardenburg's syndrome 9.7
29 cleft lip 9.7
30 incontinentia pigmenti 9.7
31 medullary sponge kidney 9.7
32 alopecia 9.7
33 eec syndrome 9.7
34 anhidrosis 9.7
35 nanophthalmos 3 9.6 EDA EDARADD MSX1 PAX9
36 taeniasis 9.3 AXIN2 EDA EDARADD MSX1 PAX9
37 beriberi 9.1 ANTXR1 AXIN2 EDA EDARADD MSX1 PAX9

Graphical network of the top 20 diseases related to Anodontia:



Diseases related to Anodontia

Symptoms & Phenotypes for Anodontia

Human phenotypes related to Anodontia:

32
id Description HPO Frequency HPO Source Accession
1 anodontia 32 HP:0000674

MGI Mouse Phenotypes related to Anodontia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.72 ANTXR1 AXIN2 EDARADD MSX1 PAX9
2 endocrine/exocrine gland MP:0005379 9.65 ANTXR1 AXIN2 EDARADD MSX1 PAX9
3 hearing/vestibular/ear MP:0005377 9.33 EDARADD MSX1 PAX9
4 limbs/digits/tail MP:0005371 9.26 AXIN2 EDARADD MSX1 PAX9
5 skeleton MP:0005390 9.02 PAX9 ANTXR1 AXIN2 EDARADD MSX1

Drugs & Therapeutics for Anodontia

Drugs for Anodontia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 4 15687-27-1 3672
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Menthol Approved Phase 4 2216-51-5 16666
4 Calcium, Dietary Phase 4
5 Acetaminophen, hydrocodone drug combination Phase 4
6 Pharmaceutical Solutions Phase 4
7
Cobalt Phase 1, Phase 2 7440-48-4 104729
8 Trace Elements Phase 1, Phase 2
9 Micronutrients Phase 1, Phase 2
10 Tea Nutraceutical Phase 2
11
Salicylic acid Approved, Vet_approved 69-72-7 338
12
Flurbiprofen Approved, Investigational Early Phase 1 5104-49-4 3394
13
Cimetidine Approved 51481-61-9 2756
14
Histamine Approved, Investigational 75614-87-8, 51-45-6 774
15 Mitogens
16 Analgesics Early Phase 1
17 Analgesics, Non-Narcotic Early Phase 1
18 Peripheral Nervous System Agents Early Phase 1
19 Anti-Infective Agents
20 Anti-Infective Agents, Local
21 Anti-Inflammatory Agents Early Phase 1
22 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
23 Antirheumatic Agents Early Phase 1
24 Carbon fiber
25 Lithium carbonate 554-13-2
26 Tranquilizing Agents
27 Antidepressive Agents
28 Psychotropic Drugs
29 Antimanic Agents
30 Central Nervous System Depressants
31 Cyclooxygenase Inhibitors Early Phase 1
32
Histamine Phosphate 51-74-1 65513
33 Gastrointestinal Agents
34 Neurotransmitter Agents
35 Cytochrome P-450 CYP1A2 Inhibitors
36 Cytochrome P-450 Enzyme Inhibitors
37 Histamine Antagonists
38 Histamine H2 Antagonists
39 Antacids
40 Anti-Ulcer Agents

Interventional clinical trials:

(show top 50) (show all 56)
id Name Status NCT ID Phase
1 Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement Unknown status NCT01603693 Phase 4
2 Guided Bone Regeneration Around Immediate Implants Completed NCT01628367 Phase 4
3 The Influence of Dimensional Anatomic Variables on the Outcomes of Maxillary Sinus Grafting Procedures Completed NCT00868777 Phase 4
4 The Effect of Platform-Matching Versus Platform-Switching Dental Implants on Peri-implant Hard and Soft Tissue Healing Recruiting NCT02536716 Phase 4
5 Peri-implant Bone Changes in Post-menopausal Osteoporotic Women Recruiting NCT02884401 Phase 4
6 TM vs TSV Implants Loaded Early vs Conventional in Anterior and Posterior Areas Recruiting NCT02158377 Phase 4
7 Survival and Success of MIS C1 Implants- a Field Study Recruiting NCT01707108 Phase 4
8 Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3
9 Alveolar Ridge Preservation With Polycaprolactone Scaffold for Implant Site Development Unknown status NCT00466414 Phase 2
10 Risk Factors for Implant Bone Loss in Patients With Diabetes Mellitus Completed NCT00933491 Phase 2
11 Interventions for Patients With a Shortened Dental Arch Completed NCT01597206 Phase 1, Phase 2
12 Clinical and Radiographic Evaluation of Crestal Bone Loss Around Implant With or Without Platform Switching Design Completed NCT02761226 Phase 2
13 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2
14 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
15 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
16 Hypodontia and Ovarian Cancer Unknown status NCT01470235
17 Clinical Study on Zirconia Bridges Unknown status NCT01835834
18 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
19 Randomized Controlled Clinical Trial of CAD/CAM and Conventionally Fabricated Singl Implant Abutments. Unknown status NCT01229995
20 Vertical Augmentation With Osteon at Dental Implant Placement Unknown status NCT01162629
21 Stability of Implants With Different Surface Treatment: Randomized Clinical Trial Unknown status NCT01699568
22 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420
23 Effect of Implant Thread Design on Implant Stability Quotient (ISQ) in Early Healing Period Completed NCT02701387
24 Chewing Side Preference and Hemispheric Laterality in Healthy Adults Completed NCT03054246
25 An Assessment of Bone Augmentation in Post-Extraction Sockets Completed NCT00641316
26 Longitudinal Efficacy of Dental Implants in Anterior Areas Completed NCT00641277
27 Clinical Study of Oral Endosseous Titanium Implants in Edentulous Subjects Completed NCT00001211
28 Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft Completed NCT01924390
29 Evaluation of the ACE Dental Implant Completed NCT00641576
30 Oral Health and People With Systemic Sclerosis Completed NCT01817361
31 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Recruiting NCT02239718
32 One-Tooth One-Time (1T1T) A Straightforward Approach to Replace Missing Teeth in the Posterior Region: a Case Series Recruiting NCT02898311
33 The Clinical Performance of Inlay Zirconia Bridges Recruiting NCT02995876
34 Long Term Dental Effects in Adolescents Who Were Treated for Cancer in Childhood Recruiting NCT02742363
35 Efficacy of Er:YAG Laser in Decontamination of Dental Implants: An In-Vitro Study Recruiting NCT03100435
36 Oral Health for Healthy Cognitive Aging Recruiting NCT02986386
37 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
38 Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries Recruiting NCT02056262
39 OHQoL With Removable Partial Dentures; a Pilot Study Active, not recruiting NCT01953991
40 Lithium Disilicate (CAD/CAM) Fixed Partial Dentures (FPD) Clinical Study Active, not recruiting NCT03036566
41 "Prospective Evaluation of Immediate & Early Loading of Zimmer Hydroxyapatite Coated Dental Implants" Active, not recruiting NCT02397044
42 Esthetic Outcomes of Immediately Placed Implants Receiving Immediate Provisionalization and Delayed Restoration Active, not recruiting NCT01925339
43 Clinical Assessment of Dental Implant Active, not recruiting NCT02591706
44 Guided Surgery Versus Sinus Graft Active, not recruiting NCT01988480
45 A Proof of Concept for All-ceramic Zirconia Resin Bonded Bridges for Canine, Premolar and Short Span Posterior Teeth Enrolling by invitation NCT02793037
46 No-preparation Resin Bonded Bridges for the Replacement of Single Missing Teeth Not yet recruiting NCT03029637
47 Clinical Trial of Zirconia and Metal Adhesive Bridges Not yet recruiting NCT01347177
48 A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials. Not yet recruiting NCT03059914
49 Influence of Superstructure Material on Crestal Bone Resorption and Esthetic Outcome of Dental Implants Not yet recruiting NCT02937220
50 Perception of Early Childhood Caries Not yet recruiting NCT02899273

Search NIH Clinical Center for Anodontia

Genetic Tests for Anodontia

Genetic tests related to Anodontia:

id Genetic test Affiliating Genes
1 Anodontia 29

Anatomical Context for Anodontia

MalaCards organs/tissues related to Anodontia:

39
Skin, Bone, Liver, Kidney

Publications for Anodontia

Articles related to Anodontia:

(show top 50) (show all 113)
id Title Authors Year
1
Early functional, esthetic, and psychological rehabilitation of preschool child with nonsyndromic oligodontia and anodontia in mixed dentition stage through conservative systematic approach: A case report with 5-year follow-up. ( 27307674 )
2016
2
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. ( 26759063 )
2016
3
Dental management of Rothmund-Thomson syndrome with partial anodontia. ( 26032705 )
2015
4
Prosthodontic management of hypohidrotic ectodermal dysplasia with anodontia: a case report in pediatric patient and review of literature. ( 23919206 )
2013
5
PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China. ( 23857653 )
2013
6
Prosthetic rehabilitation of a child suffering from hypohidrotic ectodermal dysplasia with complete anodontia. ( 25206157 )
2012
7
Total anodontia in patient with hypohidrotic ectodermal dysplasia. Report of rare case of Christ-Siemens Touraine syndrome. ( 21417166 )
2011
8
Prosthetic rehabilitation of a preschooler with induced anodontia - A clinical report. ( 22090765 )
2011
9
Ectodermal dysplasia with true anodontia. ( 22529591 )
2011
10
Prosthodontic rehabilitation of a patient with true partial anodontia - A case report. ( 23204727 )
2010
11
Ectodermal dysplasia with anodontia: a report of two cases. ( 20396456 )
2010
12
Congenital oligodontia of the deciduous teeth and anodontia of the permanent teeth in a cat. ( 18835802 )
2009
13
Congenital anodontia in ectodermal dysplasia. ( 19189682 )
2008
14
Prosthetic rehabilitation of an adolescent with hypohidrotic ectodermal dysplasia with partial anodontia: case report. ( 19008629 )
2008
15
Hypohidrotic ectodermal dysplasia with true anodontia of the primary dentition. ( 18197325 )
2007
16
Congenital hypotrichosis and partial anodontia in a crossbred beef calf. ( 17616058 )
2007
17
Prosthodontic treatment of hypohidrotic ectodermal dysplasia with complete anodontia: case report. ( 17216912 )
2007
18
Coexistent partial anodontia and supernumerary tooth in the mandibular arch: a rare case. ( 16891749 )
2006
19
Congenital hypotrichosis with anodontia in cattle: a genetic, clinical and histological analysis. ( 12464063 )
2002
20
Prosthodontic rehabilitation of a patient with partial anodontia: a clinical report. ( 12397238 )
2002
21
Clinical management of hypohidrotic ectodermal dysplasia with anodontia: case report. ( 12413164 )
2002
22
Ectodermal dysplasia with total anodontia: rehabilitation of a seven year old child. ( 12435010 )
2002
23
A rare non-syndrome case of concomitant multiple supernumerary teeth and partial anodontia. ( 11314218 )
2001
24
Oxygen, sulphide and nutrient uptake of the mangrove mud clam Anodontia edentula (Family: Lucinidae). ( 11763226 )
2001
25
Anodontia with hypohidrotic ectodermal dysplasia in a young female: a case report. ( 10730287 )
2000
26
The use of colored elastomeric "O"s as a motivational instrument for patients with anodontia: report of case. ( 10431618 )
1999
27
Partial anodontia in a case of Waardenburg's syndrome. ( 10605569 )
1999
28
Implant-supported prosthesis in a child with hereditary mandibular anodontia: the use of ball attachments. ( 9558550 )
1998
29
Primary tuberculous liver abscess associated with progressive symmetric erythrokeratodermia, anodontia and ectodermal dysplasias. ( 9828554 )
1998
30
Craniofacial changes following early prosthetic treatment in a case of hypohidrotic ectodermal dysplasia with complete anodontia. ( 9617452 )
1998
31
The use of magnets in the comprehensive treatment of congenital partial anodontia: a case report. ( 9477872 )
1997
32
Prosthetic rehabilitation of a child with induced anodontia. ( 8634197 )
1995
33
Oral rehabilitation of a patient with congenital partial anodontia using a rotational path removable partial denture: report of a case. ( 7568733 )
1995
34
Treating severe partial anodontia: a 10-year history of patient treatment. ( 7798481 )
1994
35
Anodontia associated with hypohidrotic ectodermal dysplasia. ( 1344283 )
1992
36
Dentocraniofacial structure with complete anodontia of permanent teeth: report of case. ( 1629447 )
1992
37
Overdentures in partial anodontia: simple solutions for complex problems. ( 1860126 )
1991
38
Anodontia of the permanent dentition: fourteen years after initial diagnosis. ( 2319058 )
1990
39
Anodontia as the sole clinical sign of the ectrodactyly-ectodermal dysplasia-cleft lip (EEC) syndrome. ( 2222925 )
1990
40
Complete anodontia of the permanent dentition: case report. ( 2133936 )
1990
41
Prosthetic management of hypohydrotic ectodermal dysplasia with anodontia. Case report. ( 2346400 )
1990
42
Anodontia and jaw dysplasia syndrome: an isolated, idiopathic aberration. ( 2097249 )
1990
43
Unilateral linear basal cell nevus associated with diffuse osteoma cutis, unilateral anodontia, and abnormal bone mineralization. ( 2715453 )
1989
44
Partial anodontia: a case report. ( 2598201 )
1989
45
Congenital partial anodontia: prosthodontic considerations. ( 3250573 )
1988
46
A genetic, pathological and virological study of congenital hypotrichosis and incisor anodontia in cattle. ( 2836985 )
1988
47
Familial medullary sponge kidney in association with congenital absence of teeth (anodontia). ( 3352850 )
1988
48
Ectodermal dysplasia with partial anodontia: prosthetic treatment with implant fixed prosthesis. ( 3045169 )
1988
49
Anodontia totalis fetalis in a trisomy 13 mosaic. ( 3272969 )
1988
50
Epidermolysis bullosa simplex localisata associated with anodontia, hair and nail disorders: a new syndrome. ( 2420118 )
1985

Variations for Anodontia

Expression for Anodontia

Search GEO for disease gene expression data for Anodontia.

Pathways for Anodontia

Pathways related to Anodontia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.16 AXIN2 MSX1
2 11.06 AXIN2 MSX1 PAX9
3
Show member pathways
10.89 EDA EDARADD

GO Terms for Anodontia

Biological processes related to Anodontia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.55 AXIN2 EDA EDARADD MSX1 PAX9
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.4 EDA EDARADD
3 positive regulation of canonical Wnt signaling pathway GO:0090263 9.37 AXIN2 EDA
4 odontogenesis of dentin-containing tooth GO:0042475 9.32 EDA MSX1
5 face morphogenesis GO:0060325 9.26 MSX1 PAX9
6 regulation of odontogenesis GO:0042481 8.96 MSX1 PAX9
7 odontogenesis GO:0042476 8.8 AXIN2 MSX1 PAX9

Molecular functions related to Anodontia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 8.62 MSX1 PAX9

Sources for Anodontia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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