MCID: ANR007
MIFTS: 67

Anorexia Nervosa malady

Neuronal diseases category

Summaries for Anorexia Nervosa

About this section
Sources:
8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image.

MalaCards: Anorexia Nervosa, also known as anorexia nervosa, susceptibility to, is related to bulimia nervosa and eating disorder. An important gene associated with Anorexia Nervosa is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The compounds acth and dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and pituitary, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:63 Anorexia nervosa is an eating disorder characterized by immoderate food restriction, inappropriate... more...

Description from OMIM:46 610269,606788

Aliases & Classifications for Anorexia Nervosa

About this section
Sources:
8Disease Ontology, 46OMIM, 44Novoseek, 60UMLS, 9diseasecard, 34MeSH, 27ICD9CM, 39NCIt, 56SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

anorexia nervosa 8 46 44 60
anorexia nervosa, susceptibility to 9


External Ids:

Disease Ontology8 DOID:8689
MeSH34 D000856
ICD9CM27 307.1
NCIt39 C34387
ICD1025 F50.0

Related Diseases for Anorexia Nervosa

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Anorexia Nervosa family:

Anorexia Nervosa 1

Diseases related to Anorexia Nervosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1bulimia nervosa31.6CCK, GHRL, MC4R
2eating disorder31.3PYY, GHRL, LEP
3obesity31.3PYY, CCK, LSL, HTR2A, NPY, CRH
4amenorrhea31.1CRH, IGF1, LEP
5obsessive-compulsive disorder30.8SLC6A2, HTR2A, BDNF
6pancreatitis30.7PPY, CCK
7osteoporosis30.6LEP, IGF1, NPY, LSL
8anxiety disorder30.6CRH, BDNF
9hypoglycemia30.5BDNF, LSL, HTR2A, NPY, PPY, CRH
10cushing's syndrome30.5LSL, NPY, CRH, GHSR, GHRL, GHRH
11morbid obesity30.5LEP, PYY, GHRL, MC4R, MC3R
12hyperinsulinism30.4CCK, LSL, NPY, GHRL, GHRH, IGF1
13schizophrenia30.4BDNF, CCK, HTR2A, NPY, HCRT, SLC6A2
14generalized anxiety disorder30.4HTR2A, SLC6A2
15acute pancreatitis30.4RETN, CCK
16chronic fatigue syndrome30.4CRH
17hyperthyroidism30.1LSL, GHRL, GHRH, IGF1, RETN, LEP
18hypopituitarism30.1CRH, GHRL, GHRH, IGF1, LEP
19protein-energy malnutrition30.1CCK, LSL, IGF1, LEP
20bipolar disorder30.1BDNF, HTR2A, NPY, CRH
21dementia30.1HCRT, HTR2A, BDNF
22celiac disease30.1PYY, CCK, GHRL
23craniopharyngioma30.1IGF1, HCRT
24seasonal affective disorder30.1CRH, HTR2A
25substance abuse30.1CRH
26asthma30.1GHRL, HTR2A
27endogenous depression30.1BDNF, CRH
28diabetes insipidus30.1GHRH
29gastric dilatation10.6
30hypophosphatemia10.6
31cerebritis10.5
32central pontine myelinolysis10.5
33gonadal dysgenesis10.5
34personality disorder10.5
35superior mesenteric artery syndrome10.5
36body dysmorphic disorder10.4
37delusional disorder10.4
38hypoglycemic coma10.4
39acrodermatitis10.4
40obsessive-compulsive personality disorder10.4
41alexithymia10.4
42pellagra10.4
43nephrocalcinosis10.4
44acrodermatitis enteropathica10.4
45conversion disorder10.3
46achalasia10.3
47trichotillomania10.3
48pancytopenia10.3
49scurvy10.3
50addison's disease10.3

Graphical network of the top 20 diseases related to Anorexia Nervosa:



Diseases related to anorexia nervosa

Clinical Features for Anorexia Nervosa

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

610269,606788

Drugs & Therapeutics for Anorexia Nervosa

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anorexia Nervosa

Drug clinical trials:

Search ClinicalTrials for Anorexia Nervosa

Search NIH Clinical Center for Anorexia Nervosa

Search CenterWatch for Anorexia Nervosa

Genetic Tests for Anorexia Nervosa

About this section

Anatomical Context for Anorexia Nervosa

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Anorexia Nervosa:

32
Bone, Brain, Pituitary, Testes, Liver, Heart, Cortex, Thyroid, Bone marrow, Kidney, Adipocyte, Hypothalamus, Eye, Thalamus, Pineal, Skin, Whole blood, Cingulate cortex

Animal Models for Anorexia Nervosa or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Anorexia Nervosa:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.1SLC6A2, BDNF, PYY, CCK, NPY, CRH
2MP:000538611.9CRH, PPY, NPY, HTR2A, PYY, BDNF
3MP:000537811.8GHSR, CRH, PPY, NPY, PYY, BDNF
4MP:000363111.6BDNF, PYY, CCK, NPY, CRH, GHRH
5MP:000537511.5PYY, NPY, GHSR, GHRL, AGRP, IGF1
6MP:000539011.2PYY, HTR2A, NPY, PPY, GHSR, IGF1
7MP:000537911.1HTR2A, CRH, GHRL, GHRH, IGF1, LEP
8MP:000287310.9BDNF, PYY, NPY, CRH, GHRL, AGRP

Publications for Anorexia Nervosa

About this section
Sources:
50PubMed
See all sources

Articles related to Anorexia Nervosa:

(show top 50)    (show all 1175)
idTitleAuthorsYear
1
Primary amenorrhea in anorexia nervosa: impact on characteristic masculine and feminine traits. (24123541)
2014
2
Increased resting state functional connectivity in the default mode network in recovered anorexia nervosa. (23033154)
2014
3
Body weight as a prognostic factor for day hospital success in adolescents with anorexia nervosa. (24365528)
2014
4
Follow-up of bone mineral density and body composition in adolescents with restrictive anorexia nervosa: role of dual-energy X-ray absorptiometry. (24346474)
2013
5
Treating severe and enduring anorexia nervosa: a randomized controlled trial. (23642330)
2013
6
Association between a common CYP17A1 haplotype and anxiety in female anorexia nervosa. (23775394)
2013
7
Season of birth bias and anorexia nervosa: results from an international collaboration. (23070973)
2013
8
Tandospirone, a 5-HT1A partial agonist is effective in treating anorexia nervosa: a case series. (23497393)
2013
9
Plasma klotho levels decrease in both anorexia nervosa and obesity. (23790542)
2013
10
Severely elevated transaminases in an adolescent male with anorexia nervosa. (23881604)
2013
11
Impact of physiologic estrogen replacement on anxiety symptoms, body shape perception, and eating attitudes in adolescent girls with anorexia nervosa: data from a randomized controlled trial. (24021517)
2013
12
Prognostic value of early therapeutic alliance in weight recovery: a prospective cohort of 108 adolescents with anorexia nervosa. (23299014)
2013
13
Pregnancy outcomes of women with and without a history of anorexia nervosa. (22440333)
2012
14
Emotional intelligence in anorexia nervosa: is anxiety a missing piece of the puzzle? (22703722)
2012
15
Ophthalmic changes in severe anorexia nervosa: a case series. (22407894)
2012
16
Theory of mind and the brain in anorexia nervosa: relation to treatment outcome. (22840554)
2012
17
Recovery from anorexia nervosa includes neural compensation for negative body image. (22729811)
2012
18
Convalescent resting tachycardia predicts unfavorable outcome of anorexia nervosa. (22823590)
2012
19
Predictive factors of change in BMD at 1 and 2 years in women with anorexia nervosa: a study of 146 cases. (22349911)
2012
20
Psychotropic medication use in anorexia nervosa between 1997 and 2009. (22733643)
2012
21
Changes of plasma obestatin, ghrelin and NPY in anorexia and bulimia nervosa patients before and after a high-carbohydrate breakfast. (20945961)
2011
22
Gene-environment interaction in anorexia nervosa: relevance of non-shared environment and the serotonin transporter gene. (21135854)
2011
23
Characteristics of suicide attempts in anorexia and bulimia nervosa: a case-control study. (21858173)
2011
24
Reversible vision loss secondary to malnutrition in a woman with severe anorexia nervosa, purging type, and alcohol abuse. (20186722)
2011
25
Decreased nocturnal oxytocin levels in anorexia nervosa are associated with low bone mineral density and fat mass. (21903023)
2011
26
Exercise electrocardiography extinguishes persistent junctional rhythm in a patient with severe anorexia nervosa. (22343463)
2011
27
Understanding the relation between anorexia nervosa and bulimia nervosa in a Swedish national twin sample. (19828139)
2010
28
Alexithymia and emotional awareness in anorexia nervosa: time for a shift in the measurement of the concept? (20850053)
2010
29
Genetic findings in anorexia and bulimia nervosa. (21036328)
2010
30
Deranged secretion of ghrelin and obestatin in the cephalic phase of vagal stimulation in women with anorexia nervosa. (18474361)
2008
31
Ehlersa89Danlos syndrome and anorexia nervosa: a dangerous combination? (17509113)
2007
32
Is anorexia nervosa a delusional disorder? An assessment of eating beliefs in anorexia nervosa. (17414681)
2007
33
Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea. (17284620)
2007
34
Etiology of hypercholesterolemia in patients with anorexia nervosa. (16791856)
2006
35
Letter to the Editor: Similar fasting ghrelin levels in binge eating/purging anorexia nervosa and restrictive anorexia nervosa. (15041090)
2004
36
Gender identity disorder and anorexia nervosa in male monozygotic twins. (14994364)
2004
37
Soluble leptin receptor levels in patients with anorexia nervosa. (12489569)
2002
38
The changes in serum ghrelin levels and their relationship to IGF-I, its binding proteins and leptin in women patients with anorexia nervosa]. (16737142)
2002
39
Plasma leptin, neuropeptide Y (NPY) and galanin concentrations in bulimia nervosa and in anorexia nervosa. (11600878)
2001
40
Basal metabolic rate in anorexia nervosa: relation to body composition and leptin concentrations. (10837290)
2000
41
Effects of recombinant human insulin-like growth factor I administration on spontaneous and growth hormone (GH)-releasing hormone-stimulated GH secretion in anorexia nervosa. (10946886)
2000
42
Osteomalacia in a patient with severe anorexia nervosa. (10567980)
1999
43
Addison's disease mimicking anorexia nervosa. (9793734)
1998
44
Leptin in relation to resumption of menses in women with anorexia nervosa. (9857982)
1998
45
Systemic pseudovasculitis from scurvy in anorexia nervosa. (8607903)
1996
46
Serum insulin-like growth factor-I concentrations in the recovery of patients with anorexia nervosa. (8409110)
1993
47
Effects of the glucocorticoid antagonist RU 486 on pituitary-adrenal function in patients with anorexia nervosa and healthy volunteers: enhancement of plasma ACTH and cortisol secretion in underweight patients. (8232766)
1993
48
Anorexia nervosa/bulimia and central pontine myelinolysis. (1521793)
1992
49
Anorexia nervosa associated with Klinefelter's syndrome. (1935020)
1991
50
Anorexia nervosa complicated by Mycobacterium xenopi pulmonary infection. (3655773)
1987

Genetic Variations for Anorexia Nervosa

About this section

Expression for genes affiliated with Anorexia Nervosa

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anorexia Nervosa

Search GEO for disease gene expression data for Anorexia Nervosa.

Pathways for genes affiliated with Anorexia Nervosa

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB
See all sources

Compounds for genes affiliated with Anorexia Nervosa

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Anorexia Nervosa according to GeneCards/GeneDecks:

(show top 50)    (show all 194)
idCompoundScoreTop Affiliating Genes
1acth4412.3AGRP, BDNF, PYY, CCK, LSL, NPY
2dopamine44 28 11 2415.2SLC6A2, MC3R, MC4R, HCRT, BDNF, PYY
3cocaine44 1113.0PYY, CCK, NPY, CRH, GHRL, BDNF
4testosterone44 59 11 2415.0HCRT, GHRH, GHRL, GHSR, CRH, IGF1
5glucose4411.9PYY, CCK, SLC6A2, MC3R, HCRT, IGF1
6lipid4411.9HCRT, LSL, PYY, SLC6A2, LEP, RETN
7cholesterol44 28 11 2414.9HCRT, GHRH, RETN, PYY, MC4R, IGF1
8steroid4411.9BDNF, CRH, PYY, SLC6A2, RETN, LSL
9arginine4411.8CRH, GHSR, GHRL, PYY, CCK, LSL
10adenylate4411.8BDNF, GHRH, GHSR, CRH, GHRL, SLC6A2
11corticosterone44 59 2413.8LEP, MC3R, CRH, BDNF, LSL, NPY
12norepinephrine44 11 2413.7HCRT, RETN, SLC6A2, GHRH, NPY, HTR2A
13octreotide44 59 28 1114.7PYY, CCK, LSL, NPY, CRH, GHSR
14thyroxine44 2412.7LSL, CRH, GHRH, IGF1, NPY, GHRL
15gaba4411.7BDNF, PYY, CCK, SLC6A2, CRH, HCRT
16acetylcholine44 49 28 11 2415.7SLC6A2, LEP, HCRT, CRH, GHRL, BDNF
17amphetamine44 1112.7AGRP, HCRT, MC4R, SLC6A2, GHRL, PYY
18c-peptide4411.6CCK, PYY, LSL, GHRL, IGF1, HCRT
19dexamethasone44 49 28 1114.6GHRH, IGF1, HCRT, GHSR, LSL, RETN
20haloperidol44 28 2 49 1115.6SLC6A2, HTR2A, HCRT, MC4R, NPY, LSL
215-hydroxytryptamine4411.6CCK, HTR2A, NPY, CRH, PYY, GHRL
22glutamate4411.6RETN, CCK, CRH, GHRL, GHRH, HCRT
23calcium44 49 11 2414.6BDNF, MC4R, HCRT, GHSR, NPY, HTR2A
24alpha msh4411.5MC4R, AGRP, CRH, NPY, CCK, MC3R
25oxyntomodulin44 5912.5GHRL, NPY, HCRT, AGRP, LEP, CCK
26epinephrine44 11 2413.5LSL, NPY, CRH, GHRL, SLC6A2, LEP
27opiate4411.5GHRL, CRH, NPY, CCK, GHRH, MC4R
28gnrh4411.5PYY, BDNF, MC3R, HCRT, GHRH, GHRL
29fenfluramine28 44 1113.4GHRH, CRH, NPY, HTR2A, CCK, LEP
30orlistat44 59 1113.4CCK, LEP, GHRL, NPY, LSL, PYY
31histamine44 28 2413.4PYY, HCRT, GHRL, CRH, BDNF, NPY
32carbachol44 28 1113.4NPY, GHRL, CRH, PYY, HCRT, BDNF
33forskolin44 49 1113.4RETN, GHSR, CRH, NPY, CCK, GHRH
34enterostatin4411.3LEP, CCK, CRH, NPY, HCRT
35sibutramine44 1112.3LSL, PYY, NPY, LEP, SLC6A2
36tetrodotoxin44 59 2813.3HCRT, CRH, CCK, PYY, BDNF, NPY
37hexarelin44 2812.3GHSR, GHRL, CRH, IGF1, GHRH
38estradiol44 11 2413.3GHSR, HCRT, BDNF, GHRH
39acipimox44 2812.3GHRH, GHRL, LSL, LEP, IGF1
40dhea4411.2LEP, IGF1, CRH, LSL, RETN, GHRL
41intralipid4411.2LEP, GHRL, LSL, CCK, PYY
42atropine44 28 1113.2GHRL, NPY, CCK, PYY, GHRH
43citalopram49 44 11 2414.1SLC6A2, BDNF, HTR2A
44paroxetine44 49 28 1114.1LEP, BDNF, HTR2A, GHRL, SLC6A2
45fatty acid4411.0MC4R, GHRH, AGRP, GHRL, LSL, PYY
46quetiapine44 49 28 11 2415.0BDNF, LEP, GHRL, HTR2A, LSL
47estrogen4411.0SLC6A2
48octadecaneuropeptide4411.0HCRT, CCK, NPY, GHRL
49rimonabant44 28 1112.8CCK, GHRL, LEP, HCRT
50ghrp4410.5GHRL, GHSR, GHRH, IGF1

GO Terms for genes affiliated with Anorexia Nervosa

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Anorexia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.4CCK, NPY, CRH, GHRL, GHRH, AGRP
2extracellular regionGO:00557611.3LEP, BDNF, PYY, CCK, NPY, PPY

Biological processes related to Anorexia Nervosa according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00763111.4MC4R, AGRP, CRH, NPY, PYY, BDNF
2positive regulation of cell proliferationGO:00828411.4CCK, HTR2A, CRH, GHRH, IGF1, LEP
3adult feeding behaviorGO:00834311.3NPY, GHSR, GHRL, AGRP, LEP
4eating behaviorGO:04275511.2PYY, CCK, HCRT, LEP
5positive regulation of cAMP biosynthetic processGO:03081911.2CRH, GHRH, MC4R, MC3R
6synaptic transmissionGO:00726811.2HTR2A, NPY, CRH, HCRT, SLC6A2
7positive regulation of appetiteGO:03210011.1GHRL, GHSR, NPY
8growth hormone secretionGO:03025211.1GHSR, GHRL, GHRH
9positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356811.1IGF1, GHRH, GHSR
10hormone-mediated signaling pathwayGO:00975511.1GHSR, GHRL, AGRP
11regulation of excitatory postsynaptic membrane potentialGO:06007911.1HCRT, GHRL, BDNF
12positive regulation of multicellular organism growthGO:04001811.1GHSR, GHRL, GHRH
13response to hormone stimulusGO:00972511.1GHRL, GHSR, BDNF
14response to insulin stimulusGO:03286811.0LEP, RETN, MC4R
15negative regulation of circadian sleep/wake cycle, REM sleepGO:04232211.0GHRL, CRH
16positive regulation of cortisol secretionGO:05146411.0GHRL, CRH
17digestionGO:00758611.0PPY, NPY, PYY
18negative regulation of glucagon secretionGO:07009311.0LEP, CRH
19bone mineralization involved in bone maturationGO:03563011.0IGF1, LEP
20regulation of blood pressureGO:00821711.0LEP, MC3R, NPY
21positive regulation of corticotropin secretionGO:05146110.9CRH, GHRL
22negative regulation of tumor necrosis factor biosynthetic processGO:04253610.9GHSR, GHRL
23negative regulation of interleukin-6 biosynthetic processGO:04540910.9GHSR, GHRL
24negative regulation of interleukin-1 beta productionGO:03269110.8GHSR, GHRL
25negative regulation of appetiteGO:03209910.8CCK, LEP
26positive regulation of growth hormone secretionGO:06012410.8GHRH, GHRL
27cellular component movementGO:00692810.7IGF1, NPY, PYY
28response to foodGO:03209410.7GHSR, GHRH
29actin polymerization or depolymerizationGO:00815410.7GHRL, GHSR
30negative regulation of potassium ion transportGO:04326710.6HCRT, HTR2A
31neuropeptide signaling pathwayGO:00721810.5NPY, AGRP, HCRT

Molecular functions related to Anorexia Nervosa according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.3LEP, RETN, IGF1, CRH, PPY, CCK
2neuropeptide hormone activityGO:00518411.1PYY, CCK, NPY, CRH, AGRP
3peptide hormone bindingGO:01704610.9MC3R, MC4R, GHSR
4receptor bindingGO:00510210.8AGRP, CRH, PPY, NPY
5G-protein coupled receptor bindingGO:00166410.8GHRL, PPY, NPY
6growth hormone-releasing hormone activityGO:01660810.8GHRL, GHRH
7melanocyte-stimulating hormone receptor activityGO:00498010.7MC3R, MC4R
8melanocortin receptor activityGO:00497710.6MC4R, MC3R
9neuropeptide bindingGO:04292310.4MC3R, MC4R

Products for genes affiliated with Anorexia Nervosa

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anorexia Nervosa

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet