MCID: ANR007
MIFTS: 64

Anorexia Nervosa malady

Neuronal category

Summaries for Anorexia Nervosa

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image.

MalaCards: Anorexia Nervosa, also known as anorexia nervosa, susceptibility to, is related to bulimia nervosa and amenorrhea. An important gene associated with Anorexia Nervosa is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. The compounds acth and dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Wikipedia:64 Anorexia nervosa is an eating disorder characterized by immoderate food restriction and irrational fear... more...

Description from OMIM:47 610269,606788

Aliases & Classifications for Anorexia Nervosa

Sources:
8Disease Ontology, 47OMIM, 45Novoseek, 61UMLS, 9diseasecard, 35MeSH, 27ICD9CM, 40NCIt, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

anorexia nervosa 8 47 45 61
anorexia nervosa, susceptibility to 9


External Ids:

Disease Ontology8 DOID:8689
MeSH35 D000856
ICD9CM27 307.1
NCIt40 C34387
ICD1025 F50.0

Related Diseases for Anorexia Nervosa

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Anorexia Nervosa family:

anorexia nervosa 1

Diseases related to Anorexia Nervosa via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 224)
idRelated DiseaseScoreTop Affiliating Genes
1bulimia nervosa31.6CCK, GHRL, MC4R
2amenorrhea31.2CRH, IGF1, LEP
3obsessive-compulsive disorder30.9SLC6A2, HTR2A, BDNF
4osteoporosis30.6LEP, IGF1, NPY, LSL
5anxiety disorder30.6CRH, BDNF
6hypoglycemia30.5BDNF, LSL, HTR2A, NPY, PPY, CRH
7cushing's syndrome30.5LSL, NPY, CRH, GHSR, GHRL, GHRH
8morbid obesity30.5LEP, PYY, GHRL, MC4R, MC3R
9hyperinsulinism30.4CCK, LSL, NPY, GHRL, GHRH, IGF1
10generalized anxiety disorder30.4HTR2A, SLC6A2
11acute pancreatitis30.4RETN, CCK
12chronic fatigue syndrome30.4CRH
13insulin resistance30.2LSL, HTR2A, NPY, GHRL, IGF1, MC4R
14growth hormone deficiency30.2LSL, CRH, GHSR, GHRL, GHRH, IGF1
15short stature30.2GHSR, GHRL, GHRH, IGF1, LEP
16bipolar disorder30.2BDNF, HTR2A, CRH, SLC6A2
17glucagonoma30.2GHRH, GHRL, CCK
18celiac disease30.2PYY, CCK, GHRL
19seasonal affective disorder30.2CRH, HTR2A
20substance abuse30.2CRH
21asthma30.2GHRL, HTR2A
22ileus30.2GHRL
23diabetes insipidus30.2GHRH
24n syndrome10.9
25anorexia nervosa 110.7
26gastric dilatation10.6
27hypophosphatemia10.6
28central pontine myelinolysis10.5
29superior mesenteric artery syndrome10.5
30body dysmorphic disorder10.5
31cerebral atrophy10.5
32hypoglycemic coma10.4
33acrodermatitis10.4
34obsessive-compulsive personality disorder10.4
35alexithymia10.4
36pellagra10.4
37nephrocalcinosis10.4
38acrodermatitis enteropathica10.4
39enteropathica10.4
40leukopenia10.4
41conversion disorder10.4
42achalasia10.4
43trichotillomania10.4
44pancytopenia10.4
45scurvy10.4
46klinefelter's syndrome10.3
47pulmonary aspergilloma10.3
48kwashiorkor10.3
49borderline personality disorder10.3
50congenital adrenal hyperplasia10.3

Graphical network of the top 20 diseases related to Anorexia Nervosa:



Diseases related to anorexia nervosa

Clinical Features for Anorexia Nervosa

Sources:
47OMIM
See all sources

Clinical features from OMIM:

610269,606788

Drugs & Therapeutics for Anorexia Nervosa

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anorexia Nervosa

Drug clinical trials:

Search ClinicalTrials for Anorexia Nervosa

Search NIH Clinical Center for Anorexia Nervosa

Search CenterWatch for Anorexia Nervosa

Genetic Tests for Anorexia Nervosa

Anatomical Context for Anorexia Nervosa

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anorexia Nervosa:

33
Bone marrow, Whole blood, Brain, Cortex, Heart, Skeletal muscle, Small intestine, Adipocyte, Kidney, Liver, Thyroid, Skin, T cells, B cells, Prefrontal cortex, Cingulate cortex, Temporal lobe, Thalamus, Hypothalamus, Adrenal cortex, Pineal, Pituitary

Animal Models for Anorexia Nervosa or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Anorexia Nervosa

Sources:
51PubMed
See all sources

Articles related to Anorexia Nervosa:

(show top 50)    (show all 1175)
idTitleAuthorsYear
1
Anorexia nervosa: A rogue hibernation? (24373562)
2014
2
HAomatologische VerAonderungen bei Anorexia nervosa im Kindes- und Jugendalter. (24365960)
2014
3
Steroid metabolism and excretion in anorexia nervosa. (23601423)
2013
4
Chronic starvation secondary to anorexia nervosa is associated with an adaptive suppression of resting energy expenditure. (24302748)
2013
5
Normal gray and white matter volume after weight restoration in adolescents with anorexia nervosa. (23904101)
2013
6
Levels of autistic traits in anorexia nervosa: a comparative psychometric study. (24015680)
2013
7
Deep brain stimulation for anorexia nervosa: a step forward. (24115472)
2013
8
Six women pilot deep brain stimulation for intractable anorexia nervosa. (23482980)
2013
9
Family cognitive remediation therapy for anorexia nervosa. (24096368)
2013
10
Anorexia nervosa in children and adolescents: diagnosis, treatment and the role of the pediatrician. (23422570)
2013
11
Long-term effects of enteral feeding on growth and mental health in adolescents with anorexia nervosa-results of a retrospective German cohort study. (24300908)
2013
12
Personality-based subtypes of anorexia nervosa: examining validity and utility using baseline clinical variables and ecological momentary assessment. (23792181)
2013
13
Neuropsychological variables and clinical status in anorexia nervosa: relationship between visuospatial memory and central coherence and eating disorder symptom severity. (24014260)
2013
14
Effect of non-select menus on weight and eating concern in adolescents hospitalized with anorexia nervosa. (22364346)
2012
15
Pulmonary aspergilloma in patient with anorexia nervosa: case report. (22374072)
2012
16
Plasma, salivary, and urinary oxytocin in anorexia nervosa: a pilot study. (22664406)
2012
17
Aberrant somatosensory perception in Anorexia Nervosa. (22648006)
2012
18
Spontaneous gastric perforation in an 11-year-old boy with anorexia nervosa: rare presentation with right iliac fossa pain. (22962391)
2012
19
Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa. (22797368)
2012
20
Increase in energy intake leads to a decrease in obestatin in restricting-type of anorexia nervosa. (21667437)
2011
21
Anorexia nervosa and diabetes insipidus in pregnancy. (21073912)
2011
22
Acute gastric dilatation in a patient with anorexia nervosa binge/purge subtype. (21063567)
2010
23
Brain-derived neurotrophic factor (BDNF) and set-shifting in currently ill and recovered anorexia nervosa (AN) patients. (18752728)
2009
24
Mitochondrial neurogastrointestinal encephalomyopathy mimicking anorexia nervosa. (19339372)
2009
25
Cognitive behavioral approaches in adolescent anorexia and bulimia nervosa. (19014863)
2009
26
Are anorexia nervosa and bulimia nervosa separate disorders? Challenging the 'transdiagnostic' theory of eating disorders. (18781580)
2009
27
Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1A receptor binding in right frontotemporal cortex of both lean and recovered patients: [18F]MPPF PET scan study. (18639866)
2008
28
A Dutch day treatment program for anorexia and bulimia nervosa in comparison with internationally described programs. (17676678)
2007
29
Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa. (17558893)
2007
30
Bioactive insulin-like growth factor (IGF) I and IGF-binding protein-1 in anorexia nervosa. (17389700)
2007
31
The impact of hyperactivity and leptin on recovery from anorexia nervosa. (17530161)
2007
32
Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa. (17356044)
2007
33
Chronic ACTH autoantibodies are a significant pathological factor in the disruption of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome, anorexia nervosa and major depression. (15885924)
2005
34
Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. (15531532)
2004
35
Inhibin B: a potential marker of gonadal activity in patients with anorexia nervosa during weight recovery. (15070953)
2004
36
Indicators of nutritional status in restricting-type anorexia nervosa patients: a 1-year follow-up study. (15556257)
2004
37
Somatostatin infusion withdrawal: studies in the acute and recovery phase of anorexia nervosa, and in obesity. (12590644)
2003
38
Resting energy expenditure and plasma leptin levels in adolescent girls with anorexia nervosa. (12772181)
2003
39
A case of anorexia nervosa with severe hyperlipoproteinemia. (12183941)
2002
40
Ghrelin and anorexia nervosa]. (16737135)
2002
41
Leptin in anorexia nervosa and bulimia nervosa: importance of assay technique and method of interpretation. (11919545)
2002
42
Reduced body fat in long-term followed-up female patients with anorexia nervosa. (10696835)
2000
43
Anorexia nervosa with severe liver dysfunction and subsequent critical complications. (10435364)
1999
44
A case of anorexia nervosa with hyperbilirubinaemia in a patient homozygous for a mutation in the bilirubin UDP-glucuronosyltransferase gene. (10412811)
1999
45
Effects of beta-adrenergic agonists and antagonists on the growth hormone response to growth hormone-releasing hormone in anorexia nervosa. (9494699)
1998
46
Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa. (9080262)
1997
47
Increased cholecystokinin and pancreatic polypeptide responses to a fat-rich meal in patients with restrictive but not bulimic anorexia nervosa. (9129788)
1997
48
Studies of serotonin function in anorexia nervosa. (8739113)
1996
49
Anorexia nervosa: directions for future research. Study Group on Anorexia Nervosa. (7773260)
1995
50
Anorexia nervosa: a follow-up of nutritional, hormonal and psychiatric parameters]. (8684680)
1995

Genetic Variations for Anorexia Nervosa

Expression for genes affiliated with Anorexia Nervosa

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anorexia Nervosa

Search GEO for disease gene expression data for Anorexia Nervosa.

Pathways for genes affiliated with Anorexia Nervosa

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB
See all sources

Compounds for genes affiliated with Anorexia Nervosa

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Anorexia Nervosa according to GeneCards/GeneDecks:

(show top 50)    (show all 194)
idCompoundScoreTop Affiliating Genes
1acth4512.3AGRP, BDNF, PYY, CCK, LSL, NPY
2dopamine45 29 11 2415.2SLC6A2, MC3R, MC4R, HCRT, BDNF, PYY
3cocaine45 1113.0PYY, CCK, NPY, CRH, GHRL, BDNF
4testosterone45 60 11 2415.0HCRT, GHRH, GHRL, GHSR, CRH, IGF1
5glucose4511.9PYY, CCK, SLC6A2, MC3R, HCRT, IGF1
6lipid4511.9HCRT, LSL, PYY, SLC6A2, LEP, RETN
7cholesterol45 29 11 2414.9HCRT, GHRH, RETN, PYY, MC4R, IGF1
8steroid4511.9BDNF, CRH, PYY, SLC6A2, RETN, LSL
9arginine4511.8CRH, GHSR, GHRL, PYY, CCK, LSL
10adenylate4511.8BDNF, GHRH, GHSR, CRH, GHRL, SLC6A2
11corticosterone45 60 2413.8LEP, MC3R, CRH, BDNF, LSL, NPY
12norepinephrine45 11 2413.7HCRT, RETN, SLC6A2, GHRH, NPY, HTR2A
13octreotide45 60 29 1114.7PYY, CCK, LSL, NPY, CRH, GHSR
14thyroxine45 2412.7LSL, CRH, GHRH, IGF1, NPY, GHRL
15gaba4511.7BDNF, PYY, CCK, SLC6A2, CRH, HCRT
16acetylcholine45 50 29 11 2415.7SLC6A2, LEP, HCRT, CRH, GHRL, BDNF
17amphetamine45 1112.7AGRP, HCRT, MC4R, SLC6A2, GHRL, PYY
18c-peptide4511.6CCK, PYY, LSL, GHRL, IGF1, HCRT
19dexamethasone45 50 29 1114.6GHRH, IGF1, HCRT, GHSR, LSL, RETN
20haloperidol45 29 2 50 1115.6SLC6A2, HTR2A, HCRT, MC4R, NPY, LSL
215-hydroxytryptamine4511.6CCK, HTR2A, NPY, CRH, PYY, GHRL
22glutamate4511.6RETN, CCK, CRH, GHRL, GHRH, HCRT
23calcium45 50 11 2414.6BDNF, MC4R, HCRT, GHSR, NPY, HTR2A
24alpha msh4511.5MC4R, AGRP, CRH, NPY, CCK, MC3R
25oxyntomodulin45 6012.5GHRL, NPY, HCRT, AGRP, LEP, CCK
26epinephrine45 11 2413.5LSL, NPY, CRH, GHRL, SLC6A2, LEP
27opiate4511.5GHRL, CRH, NPY, CCK, GHRH, MC4R
28gnrh4511.5PYY, BDNF, MC3R, HCRT, GHRH, GHRL
29fenfluramine29 45 1113.4GHRH, CRH, NPY, HTR2A, CCK, LEP
30orlistat45 60 1113.4CCK, LEP, GHRL, NPY, LSL, PYY
31histamine45 29 2413.4PYY, HCRT, GHRL, CRH, BDNF, NPY
32carbachol45 29 1113.4NPY, GHRL, CRH, PYY, HCRT, BDNF
33forskolin45 50 1113.4RETN, GHSR, CRH, NPY, CCK, GHRH
34enterostatin4511.3LEP, CCK, CRH, NPY, HCRT
35sibutramine45 1112.3LSL, PYY, NPY, LEP, SLC6A2
36tetrodotoxin45 60 2913.3HCRT, CRH, CCK, PYY, BDNF, NPY
37hexarelin45 2912.3GHSR, GHRL, CRH, IGF1, GHRH
38estradiol45 11 2413.3GHSR, HCRT, BDNF, GHRH
39acipimox45 2912.3GHRH, GHRL, LSL, LEP, IGF1
40dhea4511.2LEP, IGF1, CRH, LSL, RETN, GHRL
41intralipid4511.2LEP, GHRL, LSL, CCK, PYY
42atropine45 29 1113.2GHRL, NPY, CCK, PYY, GHRH
43citalopram50 45 11 2414.1SLC6A2, BDNF, HTR2A
44paroxetine45 50 29 1114.1LEP, BDNF, HTR2A, GHRL, SLC6A2
45fatty acid4511.0MC4R, GHRH, AGRP, GHRL, LSL, PYY
46quetiapine45 50 29 11 2415.0BDNF, LEP, GHRL, HTR2A, LSL
47estrogen4511.0SLC6A2
48octadecaneuropeptide4511.0HCRT, CCK, NPY, GHRL
49rimonabant45 29 1112.8CCK, GHRL, LEP, HCRT
50ghrp4510.5GHRL, GHSR, GHRH, IGF1

GO Terms for genes affiliated with Anorexia Nervosa

Sources:
16Gene Ontology
See all sources

Cellular components related to Anorexia Nervosa according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.4CCK, NPY, CRH, GHRL, GHRH, AGRP
2extracellular regionGO:00557611.3LEP, BDNF, PYY, CCK, NPY, PPY

Biological processes related to Anorexia Nervosa according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00763111.4MC4R, AGRP, CRH, NPY, PYY, BDNF
2positive regulation of cell proliferationGO:00828411.4CCK, HTR2A, CRH, GHRH, IGF1, LEP
3adult feeding behaviorGO:00834311.3NPY, GHSR, GHRL, AGRP, LEP
4eating behaviorGO:04275511.2PYY, CCK, HCRT, LEP
5positive regulation of cAMP biosynthetic processGO:03081911.2CRH, GHRH, MC4R, MC3R
6synaptic transmissionGO:00726811.2HTR2A, NPY, CRH, HCRT, SLC6A2
7positive regulation of appetiteGO:03210011.1GHRL, GHSR, NPY
8growth hormone secretionGO:03025211.1GHSR, GHRL, GHRH
9positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356811.1IGF1, GHRH, GHSR
10hormone-mediated signaling pathwayGO:00975511.1GHSR, GHRL, AGRP
11regulation of excitatory postsynaptic membrane potentialGO:06007911.1HCRT, GHRL, BDNF
12positive regulation of multicellular organism growthGO:04001811.1GHSR, GHRL, GHRH
13response to hormone stimulusGO:00972511.1GHRL, GHSR, BDNF
14response to insulin stimulusGO:03286811.0LEP, RETN, MC4R
15negative regulation of circadian sleep/wake cycle, REM sleepGO:04232211.0GHRL, CRH
16positive regulation of cortisol secretionGO:05146411.0GHRL, CRH
17digestionGO:00758611.0PPY, NPY, PYY
18negative regulation of glucagon secretionGO:07009311.0LEP, CRH
19bone mineralization involved in bone maturationGO:03563011.0IGF1, LEP
20regulation of blood pressureGO:00821711.0LEP, MC3R, NPY
21positive regulation of corticotropin secretionGO:05146110.9CRH, GHRL
22negative regulation of tumor necrosis factor biosynthetic processGO:04253610.9GHSR, GHRL
23negative regulation of interleukin-6 biosynthetic processGO:04540910.9GHSR, GHRL
24negative regulation of interleukin-1 beta productionGO:03269110.8GHSR, GHRL
25negative regulation of appetiteGO:03209910.8CCK, LEP
26positive regulation of growth hormone secretionGO:06012410.8GHRH, GHRL
27cellular component movementGO:00692810.7IGF1, NPY, PYY
28response to foodGO:03209410.7GHSR, GHRH
29actin polymerization or depolymerizationGO:00815410.7GHRL, GHSR
30negative regulation of potassium ion transportGO:04326710.6HCRT, HTR2A
31neuropeptide signaling pathwayGO:00721810.5NPY, AGRP, HCRT

Molecular functions related to Anorexia Nervosa according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.3LEP, RETN, IGF1, CRH, PPY, CCK
2neuropeptide hormone activityGO:00518411.1PYY, CCK, NPY, CRH, AGRP
3peptide hormone bindingGO:01704610.9MC3R, MC4R, GHSR
4receptor bindingGO:00510210.8AGRP, CRH, PPY, NPY
5G-protein coupled receptor bindingGO:00166410.8GHRL, PPY, NPY
6growth hormone-releasing hormone activityGO:01660810.8GHRL, GHRH
7melanocyte-stimulating hormone receptor activityGO:00498010.7MC3R, MC4R
8melanocortin receptor activityGO:00497710.6MC4R, MC3R
9neuropeptide bindingGO:04292310.4MC3R, MC4R

Products for genes affiliated with Anorexia Nervosa

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Sources for Anorexia Nervosa

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet