MCID: ANR007
MIFTS: 62

Anorexia Nervosa malady

Genetic diseases (common), Mental diseases, Neuronal diseases categories

Summaries for Anorexia Nervosa

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OMIM:45 Eating disorders are characterized by severe disturbances in eating behavior that typically have onset during late... (606788) more...

MalaCards based summary: Anorexia Nervosa, also known as bulimia nervosa 2, is related to bulimia nervosa and eating disorder. An important gene associated with Anorexia Nervosa is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are Syndecan-3-mediated signaling events and Adipocytokine signaling pathway. The compounds octadecaneuropeptide and rimonabant have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and pituitary, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Disease Ontology:9 An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image.

Wikipedia:63 Anorexia nervosa is an eating disorder characterized by food restriction, inappropriate eating habits or... more...

Description from OMIM:45 610269

Aliases & Classifications for Anorexia Nervosa

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Sources:
45OMIM, 9Disease Ontology, 10diseasecard, 43Novoseek, 22GTR, 60UMLS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 33MeSH, 25ICD10
See all sources

Anorexia Nervosa, Aliases & Descriptions:

Name: Anorexia Nervosa 45 9 43 60
Bulimia Nervosa 2 45 22
 
Anorexia Nervosa, Susceptibility to, 1 10
Anorexia Nervosa, Susceptibility to 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology9 DOID:8689
ICD9CM27 307.1
NCIt38 C34387
MeSH33 D000856
ICD1025 F50.0

Related Diseases for Anorexia Nervosa

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Diseases related to Anorexia Nervosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1bulimia nervosa32.1CCK, MC4R, GHRL
2eating disorder32.1PYY, LEP, GHRL
3amenorrhea31.7CRH, LEP
4obsessive-compulsive disorder31.4HTR2A, BDNF, SLC6A2
5anxiety disorder31.2CRH, BDNF
6cushing's syndrome31.2CRH, GHRH
7generalized anxiety disorder31.1HTR2A, SLC6A2
8exocrine pancreatic insufficiency30.9PPY, CCK
9protein-energy malnutrition30.8CCK, LEP
10glucagonoma30.8GHRH, CCK, GHRL
11celiac disease30.7GHRL, CCK, PYY
12hyperthyroidism30.7LEP, RETN, GHRH, GHRL
13schizophrenia30.6SLC6A2, BDNF, NPY, HTR2A, HCRT, CCK
14substance abuse30.6CRH
15hypopituitarism30.6CRH, LEP, GHRH, GHRL
16dementia30.6BDNF, HTR2A, HCRT
17hyperinsulinism30.6MC4R, LEP, GHRL, RETN, NPY
18bipolar disorder30.5CRH, SLC6A2, BDNF, HTR2A
19growth hormone deficiency30.5GHSR, CRH, GHRL, GHRH, LEP
20hypoglycemia30.4GHRH, HTR2A, HCRT, CRH, GHRL, BDNF
21ischemia30.4UCN, GHRL, HCRT, BDNF, SLC6A2
22morbid obesity30.4MC3R, MC4R, RETN, CCK, GHRL, PYY
23obesity29.5AGRP, SLC6A2, NPY, CRH, UCN, GHSR
24gastric dilatation10.7
25hypophosphatemia10.7
26body dysmorphic disorder10.6
27personality disorder10.6
28central pontine myelinolysis10.6
29cerebritis10.6
30superior mesenteric artery syndrome10.6
31gonadal dysgenesis10.6
32insulin-like growth factor i10.5
33pancreatitis10.5
34duodenogastric reflux10.5CCK
35alexithymia10.5
36cerebral atrophy10.5
37neuroendocrine tumor10.5PPY, GHRH
38dysthymic disorder10.5HTR2A, HCRT
39nutritional deficiency disease10.5GHRL, LEP
40osteoporosis10.4
41hypoglycemic coma10.4
42obsessive-compulsive personality disorder10.4
43pellagra10.4
44nephrocalcinosis10.4
45leukopenia10.4
46acquired generalized lipodystrophy10.4RETN, LEP
47neuroblastoma10.4BDNF, SLC6A2
48anovulation10.4GHRL, LEP
49obstructive sleep apnea10.4HTR2A, LEP, HCRT
50gastroparesis10.4GHRL, GHSR, CCK

Graphical network of the top 20 diseases related to Anorexia Nervosa:



Diseases related to anorexia nervosa

Symptoms for Anorexia Nervosa

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Clinical features from OMIM:

606788,610269

Drugs & Therapeutics for Anorexia Nervosa

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Drug clinical trials:

Search ClinicalTrials for Anorexia Nervosa

Search NIH Clinical Center for Anorexia Nervosa

Genetic Tests for Anorexia Nervosa

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Genetic tests related to Anorexia Nervosa:

id Genetic test Affiliating Genes
1 Bulimia Nervosa 222

Anatomical Context for Anorexia Nervosa

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MalaCards organs/tissues related to Anorexia Nervosa:

31
Bone, Brain, Pituitary, Testes, Liver, Cortex, Heart, Thyroid, Bone marrow, Adipocyte, Kidney, Hypothalamus, Eye, Whole blood, Skin, Cingulate cortex, Thalamus, Pineal

Animal Models for Anorexia Nervosa or affiliated genes

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MGI Mouse Phenotypes related to Anorexia Nervosa:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.2CRH, GHRL, GHRH, HTR2A, CCK, LEP
2MP:00053709.1LEP, MC4R, RETN, GHRH, NPY, AGRP
3MP:00053819.1LEP, HTR2A, GHRL, GHSR, NPY, BDNF
4MP:00028738.7PYY, MC4R, GHRL, CRH, NPY, BDNF
5MP:00053758.7PYY, LEP, MC3R, MC4R, RETN, GHRL
6MP:00053908.7PPY, PYY, LEP, MC3R, MC4R, HTR2A
7MP:00036317.6CCK, MC4R, LEP, HCRT, PYY, GHRH
8MP:00053787.6MC3R, LEP, HCRT, PYY, PPY, MC4R
9MP:00053867.1AGRP, PPY, PYY, HCRT, LEP, MC3R
10MP:00053766.9CCK, RETN, MC4R, MC3R, LEP, HCRT

Publications for Anorexia Nervosa

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Articles related to Anorexia Nervosa:

(show top 50)    (show all 1171)
idTitleAuthorsYear
1
Salience network and olanzapine in schizophrenia: implications for treatment in anorexia nervosa. (25886678)
2015
2
Structural hippocampal alterations, perceived stress, and coping deficiencies in patients with anorexia nervosa. (25864963)
2015
3
Irisin Levels are Not Affected by Physical Activity in Patients with Anorexia Nervosa. (24432013)
2014
4
Perfectionism in anorexia nervosa: novel performance based evidence. (25360690)
2014
5
Chicken or the Egg: Anorexia Nervosa and Systemic Lupus Erythematosus in Children and Adolescents. (24394681)
2014
6
Is there a family profile of addictive behaviors? Family functioning in anorexia nervosa and drug dependence disorder. (23794317)
2014
7
Treatment Refusal in Anorexia Nervosa: The Hardest of Cases : Commentary on "Anorexia Nervosa: The Diagnosis: A Postmodern Ethics Contribution to the Bioethics Debate on Involuntary Treatment for Anorexia Nervosa" by Sacha Kendall. (24415127)
2014
8
Diagnosing and managing anorexia nervosa in UK primary care: a focus group study. (23603747)
2013
9
Decreased whole-blood global DNA methylation is related to serum hormones in anorexia nervosa adolescents. (24286295)
2013
10
Higher calorie diets increase rate of weight gain and shorten hospital stay in hospitalized adolescents with anorexia nervosa. (24054812)
2013
11
A qualitative exploration of influences on the process of recovery from personal written accounts of people with anorexia nervosa. (24093452)
2013
12
The MOSAIC study - comparison of the Maudsley Model of Treatment for Adults with Anorexia Nervosa (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with anorexia nervosa or eating disorder not otherwise specified, anorexia nervosa type: study protocol for a randomized controlled trial. (23721562)
2013
13
Neuropsychological functioning in adolescents with anorexia nervosa before and after cognitive remediation therapy: a feasibility trial. (23828636)
2013
14
Impact of speed and magnitude of weight loss on the development of brain trophic changes in adolescents with anorexia nervosa: a case control study. (23418915)
2013
15
The relationship between obsessive-compulsive personality disorder traits, obsessive-compulsive disorder and excessive exercise in patients with anorexia nervosa: a systematic review. (24999397)
2013
16
Patients with anorexia nervosa receiving acupuncture or acupressure; their view of the therapeutic encounter. (24280477)
2013
17
How much should I eat? Estimation of meal portions in anorexia nervosa. (23276722)
2013
18
Psychosomatic syndromes and anorexia nervosa. (23302180)
2013
19
Follow-up of bone mineral density and body composition in adolescents with restrictive anorexia nervosa: role of dual-energy X-ray absorptiometry. (24346474)
2013
20
The role of affect in the maintenance of anorexia nervosa: evidence from a naturalistic assessment of momentary behaviors and emotion. (24016011)
2013
21
Estrogen and leptin regulation of endocrinological features of anorexia nervosa. (23147480)
2013
22
Leg swelling a patient with anorexia nervosa. (23162930)
2012
23
Anorexia nervosa--a noradrenergic dysregulation hypothesis. (22326200)
2012
24
Assessment of serum levels resistin in girls with anorexia nervosa. Part II. Relationships between serum levels of resistin and thyroid, adrenal and gonadal hormones. (22167129)
2011
25
Aripiprazole in anorexia nervosa and low-weight bulimia nervosa: case reports. (20186719)
2011
26
Increase in energy intake leads to a decrease in obestatin in restricting-type of anorexia nervosa. (21667437)
2011
27
Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa. (19931436)
2010
28
Dialectical behaviour therapy and an added cognitive behavioural treatment module for eating disorders in women with borderline personality disorder and anorexia nervosa or bulimia nervosa who failed to respond to previous treatments. An open trial with a 15-month follow-up. (20444442)
2010
29
Brain-derived neurotrophic factor (BDNF) and set-shifting in currently ill and recovered anorexia nervosa (AN) patients. (18752728)
2009
30
Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers. (19680270)
2009
31
Polymorphisms in serotonin-related genes in anorexia nervosa. The first study in Czech population and metaanalyses with previously performed studies. (19863848)
2009
32
Somatic and psychological factors related to the body mass index of patients with anorexia nervosa. (19169076)
2008
33
Severe hypoglycemia in a patient with anorexia nervosa. (18319628)
2008
34
The role of leptin and orexins in the dysfunction of hypothalamo-pituitary-gonadal regulation and in the mechanism of hyperactivity in patients with anorexia nervosa. (18283238)
2008
35
Increased insulin sensitivity in patients with anorexia nervosa: the role of adipocytokines. (17184143)
2007
36
Anorexia nervosa patients with a prior history of bulimia nervosa. (17067877)
2006
37
The transcript expression profile of the leptin receptor-coding gene assayed with the oligonucleotide microarray technique--could this be an anorexia nervosa marker? (16847749)
2006
38
Severe hypophosphatemia in a patient with anorexia nervosa during enteral refeeding. (15819381)
2004
39
Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. (15026526)
2004
40
Leptin levels in female patients with restrictive and purgative types of anorexia nervosa]. (12920794)
2003
41
Rectal prolapse: a possibly underrecognized complication of anorexia nervosa amenable to surgical correction. (11841132)
2001
42
5-HT2A gene promoter polymorphism and anorexia nervosa. (10094013)
1999
43
Changes in plasma concentrations of leptin and body fat composition during weight restoration in anorexia nervosa. (10372743)
1999
44
No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. (10088048)
1999
45
Addison's disease mimicking anorexia nervosa. (9793734)
1998
46
Association between 5-HT2A gene promoter polymorphism and anorexia nervosa. (9259661)
1997
47
Anorexia nervosa: directions for future research. Study Group on Anorexia Nervosa. (7773260)
1995
48
Serum insulin-like growth factor-I concentrations in the recovery of patients with anorexia nervosa. (8409110)
1993
49
A possible direct precursor of thyrotropin-releasing hormone, pGlu-His-Pro-Gly, stimulates prolactin secretion in anorexia nervosa. (2115046)
1990
50
Acute gastric dilatation in anorexia nervosa. (4834098)
1974

Variations for Anorexia Nervosa

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Expression for genes affiliated with Anorexia Nervosa

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Search GEO for disease gene expression data for Anorexia Nervosa.

Pathways for genes affiliated with Anorexia Nervosa

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Compounds for genes affiliated with Anorexia Nervosa

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Compounds related to Anorexia Nervosa according to GeneCards Suite gene sharing:

(show top 50)    (show all 211)
idCompoundScoreTop Affiliating Genes
1octadecaneuropeptide439.9CCK, GHRL, NPY, HCRT
2rimonabant43 28 1211.8HCRT, LEP, CCK, GHRL
3paroxetine43 49 28 1212.8LEP, HTR2A, SLC6A2, BDNF, GHRL
4enterostatin439.7HCRT, LEP, CCK, CRH, NPY
5orlistat43 59 1211.7CCK, LEP, GHRL, PYY, NPY
6pramlintide43 1210.7GHRL, PYY, LEP, CCK
7sibutramine43 1210.6LEP, SLC6A2, NPY, PYY
8fenfluramine43 28 1211.6LEP, NPY, CRH, HTR2A, CCK, GHRH
9c-peptide439.5GHRL, PYY, LEP, HCRT, CCK, RETN
10naloxone43 28 49 1212.5CCK, CRH, GHRL, GHRH, LEP
11oxyntomodulin43 5910.5HCRT, NPY, GHRL, CCK, LEP, PYY
12mhpg439.5SLC6A2, BDNF, NPY, CRH
13tetrodotoxin43 59 2811.4CCK, NPY, PYY, BDNF, HCRT, CRH
14atropine43 28 1211.4PYY, CCK, CRH, GHRL, GHRH, NPY
15nifedipine43 28 49 1212.4BDNF, GHRH, CRH, NPY, GHRL, LEP
16hexarelin43 2810.3GHRL, GHSR, CRH, GHRH
17octreotide43 59 28 1212.3CRH, GHSR, GHRL, GHRH, CCK, PYY
18citalopram43 49 24 1212.3CRH, LEP, SLC6A2, BDNF, HTR2A
19carbachol43 28 1211.3CRH, GHRL, NPY, CCK, HCRT, PYY
20haloperidol43 49 28 2 1213.2BDNF, MC4R, HCRT, HTR2A, SLC6A2, NPY
21alpha msh439.2CCK, LEP, AGRP, NPY, CRH, MC4R
22thyroxine43 2410.2HCRT, LEP, NPY, GHRH, RETN, GHRL
23opiate439.2GHRH, HCRT, MC4R, CCK, NPY, CRH
24epinephrine43 24 1211.1HCRT, LEP, GHRL, CRH, NPY, SLC6A2
255-hydroxytryptamine439.0HCRT, NPY, CRH, GHRL, HTR2A, CCK
26amphetamine43 49 1211.0PYY, HCRT, MC4R, CCK, GHRL, NPY
27estradiol43 24 1211.0GHRL, CRH, RETN, HCRT, PYY, GHRH
28gnrh439.0BDNF, PYY, HCRT, LEP, MC3R, GHRL
29fatty acid438.9MC4R, RETN, PYY, AGRP, GHRL, GHRH
30gaba438.9SLC6A2, NPY, PYY, HCRT, CRH, LEP
31cholesterol43 28 24 1211.8BDNF, GHRL, CCK, RETN, MC4R, HCRT
32testosterone43 59 24 1211.7NPY, RETN, HCRT, LEP, CCK, GHRL
33corticosterone43 59 2410.7CRH, NPY, BDNF, UCN, GHRL, MC4R
34cyclic amp43 249.6BDNF, NPY, PYY, HCRT, MC3R, GHRH
35histamine43 28 2410.6CRH, UCN, GHRL, SLC6A2, PYY, BDNF
36glutamate438.5GHRL, CRH, CCK, RETN, LEP, NPY
37acetylcholine43 49 28 24 1212.5SLC6A2, BDNF, HCRT, NPY, CRH, PYY
38dexamethasone43 49 28 1211.5GHSR, CCK, GHRL, GHRH, RETN, LEP
39forskolin43 49 1210.5CCK, BDNF, SLC6A2, NPY, CRH, RETN
40arginine438.3GHSR, UCN, CRH, NPY, GHRL, GHRH
41steroid438.3LEP, BDNF, MC4R, SLC6A2, UCN, GHSR
42lipid438.2GHRH, PYY, GHSR, GHRL, CFD, MC4R
43adenylate438.2GHSR, SLC6A2, NPY, CRH, UCN, GHRL
44estrogen438.1PYY, NPY, CRH, GHSR, UCN, GHRL
45norepinephrine43 24 129.9CRH, NPY, BDNF, SLC6A2, UCN, GHRL
46cocaine43 128.8MC4R, CCK, GHRL, UCN, CRH, NPY
47acth437.7BDNF, AGRP, MC3R, MC4R, NPY, CRH
48dopamine43 28 24 1210.6CRH, NPY, BDNF, SLC6A2, UCN, PYY
49calcium43 49 24 1210.5BDNF, HCRT, CFD, MC3R, SLC6A2, PYY
50glucose437.2AGRP, SLC6A2, BDNF, NPY, UCN, GHRL

GO Terms for genes affiliated with Anorexia Nervosa

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Cellular components related to Anorexia Nervosa according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304249.9CCK, GHRL, HTR2A
2varicosityGO:00431969.5CRH, UCN
3perikaryonGO:00432049.4UCN, CRH, CCK
4extracellular spaceGO:00056158.2RETN, LEP, CFD, PYY, CCK, GHRH
5extracellular regionGO:00055767.6BDNF, PPY, PYY, HCRT, CFD, LEP

Biological processes related to Anorexia Nervosa according to GeneCards Suite gene sharing:

(show all 41)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of tumor necrosis factor biosynthetic processGO:004253610.5GHSR, GHRL
2negative regulation of interleukin-6 biosynthetic processGO:004540910.4GHRL, GHSR
3negative regulation of interleukin-1 beta productionGO:003269110.4GHSR, GHRL
4positive regulation of cortisol secretionGO:005146410.4GHRL, CRH
5negative regulation of circadian sleep/wake cycle, REM sleepGO:004232210.4GHRL, CRH
6positive regulation of growth hormone secretionGO:006012410.4GHRL, GHRH
7hormone-mediated signaling pathwayGO:000975510.3AGRP, GHSR, GHRL
8negative regulation of glucagon secretionGO:007009310.3CRH, LEP
9response to hormoneGO:000972510.3BDNF, GHSR, GHRL
10growth hormone secretionGO:003025210.3GHSR, GHRL, GHRH
11regulation of excitatory postsynaptic membrane potentialGO:006007910.3BDNF, GHRL, HCRT
12positive regulation of insulin-like growth factor receptor signaling pathwayGO:004356810.3GHRH, GHSR
13negative regulation of potassium ion transportGO:004326710.3HCRT, HTR2A
14actin polymerization or depolymerizationGO:000815410.3GHRL, GHSR
15positive regulation of multicellular organism growthGO:004001810.3GHSR, GHRL, GHRH
16positive regulation of appetiteGO:003210010.3GHRL, GHSR, NPY
17response to foodGO:003209410.2GHRH, GHSR
18decidualizationGO:004669710.2GHSR, GHRL
19regulation of blood pressureGO:000821710.1NPY, MC3R, LEP
20negative regulation of insulin secretionGO:004667610.1GHSR, GHRL
21central nervous system neuron developmentGO:002195410.1LEP, NPY
22positive regulation of behavioral fear responseGO:0200098710.1CRH, UCN
23negative regulation of appetiteGO:003209910.1UCN, CCK, LEP
24positive regulation of synapse assemblyGO:005196510.0GHRL, BDNF
25positive regulation of corticotropin secretionGO:005146110.0CRH, UCN, GHRL
26positive regulation of calcium ion importGO:009028010.0UCN, CRH
27digestionGO:000758610.0PPY, PYY, NPY
28response to insulinGO:00328689.9AGRP, RETN, MC4R, LEP
29adult feeding behaviorGO:00083439.9AGRP, NPY, GHSR, GHRL, LEP
30negative regulation of feeding behaviorGO:020002529.9MC4R, RETN, UCN
31eating behaviorGO:00427559.9PYY, HCRT, LEP, CCK, AGRP
32response to painGO:00482659.9UCN, CRH, SLC6A2
33female pregnancyGO:00075659.8LEP, UCN, CRH
34neuropeptide signaling pathwayGO:00072189.8HCRT, UCN, NPY, AGRP
35behavioral fear responseGO:00016629.8CCK, BDNF
36associative learningGO:00083069.8CRH, UCN
37G-protein coupled receptor signaling pathwayGO:00071869.8UCN, GHSR, GHRL, PYY
38positive regulation of cell proliferationGO:00082849.7LEP, CCK, HTR2A, GHRH, CRH
39synaptic transmissionGO:00072689.6HCRT, HTR2A, CRH, NPY, SLC6A2
40positive regulation of cAMP biosynthetic processGO:00308199.5CRH, UCN, GHRH, MC4R, MC3R
41feeding behaviorGO:00076319.4PYY, MC4R, CRH, NPY, BDNF, AGRP

Molecular functions related to Anorexia Nervosa according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1growth hormone-releasing hormone activityGO:001660810.2GHRL, GHRH
2melanocyte-stimulating hormone receptor activityGO:000498010.1MC4R, MC3R
3peptide hormone bindingGO:001704610.0GHSR, MC4R, MC3R
4G-protein coupled receptor bindingGO:00016649.9PPY, GHRL, NPY
5melanocortin receptor activityGO:00049779.9MC4R, MC3R
6corticotropin-releasing hormone receptor 1 bindingGO:00514309.8CRH, UCN
7corticotropin-releasing hormone receptor 2 bindingGO:00514319.8UCN, CRH
8neuropeptide bindingGO:00429239.7MC4R, MC3R
9receptor bindingGO:00051029.4AGRP, NPY, CRH, PPY
10hormone activityGO:00051799.2PPY, PYY, LEP, RETN, CCK, CRH
11neuropeptide hormone activityGO:00051849.1AGRP, NPY, CRH, UCN, CCK, PYY

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Sources for Anorexia Nervosa

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3CDC
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