MCID: ANR007
MIFTS: 60

Anorexia Nervosa

Categories: Genetic diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Anorexia Nervosa

MalaCards integrated aliases for Anorexia Nervosa:

Name: Anorexia Nervosa 54 12 52 42 14 69
Bulimia Nervosa 2 71 29
Bulimia Nervosa 42 69
Anorexia Nervosa, Susceptibility to 13
Anorexia Nervosa 2 71
Anon2 71
Buln2 71

Classifications:



External Ids:

OMIM 54 610269
Disease Ontology 12 DOID:8689
ICD10 33 F50.0 F50.00
ICD9CM 35 307.1
NCIt 47 C34387
UMLS 69 C0003125

Summaries for Anorexia Nervosa

UniProtKB/Swiss-Prot : 71 Anorexia nervosa 2: An eating disorder characterized by the lack or loss of appetite, excess fear of becoming overweight, body image disturbance, significant weight loss, refusal to maintain minimal normal weight, and amenorrhea. Bulimia nervosa 2: A psychiatric disorder characterized by eating an unusually large amount of food in a short period of time, followed by inappropriate acts (purging) to avert weight gain. Compensatory behavior includes self-induced vomiting, laxative abuse, and excessive exercise.

MalaCards based summary : Anorexia Nervosa, also known as bulimia nervosa 2, is related to obsessive-compulsive personality disorder and hypoglycemic coma. An important gene associated with Anorexia Nervosa is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are Peptide ligand-binding receptors and Prolactin Signaling Pathway. The drugs Aripiprazole and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and heart, and related phenotypes are behavior/neurological and homeostasis/metabolism

OMIM : 54
For a phenotypic description and a discussion of heterogeneity of susceptibility to bulimia nervosa, see 607499. For a phenotypic description and a discussion of heterogeneity of susceptibility to anorexia nervosa, see 606788. (610269)

Disease Ontology : 12 An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image.

Wikipedia : 72 Anorexia nervosa, often referred to simply as anorexia, is an eating disorder characterized by low... more...

Related Diseases for Anorexia Nervosa

Diseases in the Anorexia Nervosa family:

Anorexia Nervosa 1

Diseases related to Anorexia Nervosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
id Related Disease Score Top Affiliating Genes
1 obsessive-compulsive personality disorder 30.1 BDNF COMT HTR2A SLC6A4
2 hypoglycemic coma 29.9 BDNF CRH HTR2A SLC6A4
3 pervasive developmental disorder 28.8 BDNF CCK COMT GHRL POMC SLC6A4
4 schizophrenia 28.7 BDNF CCK COMT HTR2A NPY PRL
5 personality disorder 28.5 BDNF CCK COMT CRH HTR2A POMC
6 anorexia nervosa 1 12.4
7 eating disorder 11.6
8 body dysmorphic disorder 11.4
9 pili torti 11.3
10 g6pc3 deficiency 10.8 GH1 PRL
11 prolactin producing pituitary tumor 10.8 IGF1 POMC
12 cleft lip and palate malrotation cardiopathy 10.8 LEP POMC
13 bulimia nervosa 10.7
14 porokeratosis 10.7 IGF1 LEP PRL
15 combined t cell and b cell immunodeficiency 10.7 GH1 PRL
16 african histoplasmosis 10.7 POMC PRL
17 adamantinous craniopharyngioma 10.6 GHRL IGF1 PRL
18 pituitary adenoma, prolactin-secreting 10.6 GH1 IGF1 PRL
19 osseous heteroplasia, progressive 10.6 GH1 IGF1 PRL
20 immune system organ benign neoplasm 10.6 IGF1 POMC PRL
21 worth's syndrome 10.6 GH1 IGF1 PRL
22 lymphoma, gastric non hodgkins type 10.6 GH1 POMC
23 aortic valve atresia 10.6 GH1 POMC PRL
24 luxation of globe 10.6 NPY PRL SLC6A4
25 lactic acidosis 10.6 GH1 POMC PRL
26 fibrolamellar carcinoma 10.6 IGF1 POMC PRL
27 complement component 8 deficiency 10.6 IGF1 LEP
28 tropical sprue 10.6 CCK IGF1 PYY
29 dyspepsia 10.6 CCK NPY PRL
30 retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities 10.5 CCK GHRL PYY
31 pelvic muscle wasting 10.5 IGF1 POMC PRL
32 male reproductive organ benign neoplasm 10.5 IGF1 POMC PRL
33 suppurative periapical periodontitis 10.5 IGF1 POMC SLC6A4
34 precursor b lymphoblastic lymphoma/leukemia 10.5 GHRL IGF1 LEP PRL
35 lymphoepithelioma-like carcinoma 10.5 POMC PRL
36 exostosis 10.5 GHRL IGF1 LEP
37 postencephalitic parkinson disease 10.5 BDNF HTR2A SLC6A4
38 obesity 10.5
39 skin meningioma 10.5 GH1 GHRL LEP PRL
40 ornithosis 10.5 CCK PRL SLC6A4
41 acute female pelvic peritonitis 10.5 POMC PRL SLC6A4
42 mandibular cancer 10.5 CCK GHRL SLC6A4
43 lipase deficiency, combined 10.5 GH1 IGF1
44 alcoholic liver cirrhosis 10.4 BDNF PRL SLC6A4
45 sweat gland cancer 10.4 CCK PYY SLC6A4
46 hypothyroidism, congenital, nongoitrous 4 10.4 GH1 IGF1 POMC PRL
47 exophthalmic ophthalmoplegia 10.4 ADIPOQ LEP LEPR
48 psychogenic movement 10.4 GH1 IGF1 POMC PRL
49 amenorrhea 10.4
50 alpha-methylacyl-coa racemase deficiency 10.4 GH1 IGF1 POMC PRL

Comorbidity relations with Anorexia Nervosa via Phenotypic Disease Network (PDN):


Acute Cystitis Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Anorexia Nervosa:



Diseases related to Anorexia Nervosa

Symptoms & Phenotypes for Anorexia Nervosa

Clinical features from OMIM:

610269

MGI Mouse Phenotypes related to Anorexia Nervosa:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.43 ADIPOQ AGRP BDNF CCK COMT CRH
2 homeostasis/metabolism MP:0005376 10.43 LEPR NPY POMC PRL PYY RETN
3 endocrine/exocrine gland MP:0005379 10.39 ADIPOQ BDNF CCK COMT CRH GHR
4 adipose tissue MP:0005375 10.31 PYY RETN ADIPOQ AGRP CRH GHR
5 growth/size/body region MP:0005378 10.31 ADIPOQ AGRP BDNF CRH GHR GHRH
6 nervous system MP:0003631 10.24 AGRP BDNF CCK COMT CRH GHR
7 immune system MP:0005387 10.2 ADIPOQ COMT CRH GHR GHRH IGF1
8 liver/biliary system MP:0005370 10.14 POMC PRL RETN ADIPOQ AGRP CRH
9 integument MP:0010771 10.13 BDNF CRH GHR IGF1 LEP LEPR
10 normal MP:0002873 9.97 PYY SLC6A4 AGRP BDNF CRH GHRL
11 renal/urinary system MP:0005367 9.91 ADIPOQ COMT CRH GHR IGF1 LEP
12 reproductive system MP:0005389 9.81 AGRP BDNF COMT GHR GHRH IGF1
13 respiratory system MP:0005388 9.5 ADIPOQ BDNF COMT CRH IGF1 LEP
14 skeleton MP:0005390 9.28 LEPR NPY PYY ADIPOQ CRH GHR

Drugs & Therapeutics for Anorexia Nervosa

Drugs for Anorexia Nervosa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 169)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 2 132539-06-1 4585
4
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
5
Amphetamine Approved, Illicit Phase 4 300-62-9 5826 3007
6
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
7
Dextroamphetamine Approved, Illicit Phase 4 51-64-9 5826
8 Raclopride Investigational Phase 4 84225-95-6
9 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
10 Tranquilizing Agents Phase 4,Phase 3,Phase 2
11 Psychotropic Drugs Phase 4,Phase 3,Phase 2
12 Antipsychotic Agents Phase 4,Phase 3,Phase 2
13
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
14 Adrenergic Agents Phase 4
15 Central Nervous System Stimulants Phase 4
16 Serotonin Agents Phase 4,Phase 3,Phase 2
17 Serotonin Antagonists Phase 4
18 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
20 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
21 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
22 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
23 Cytochrome P-450 Enzyme Inhibitors Phase 4
24 Dopamine Agents Phase 4
25 Dopamine Antagonists Phase 4
26 Dopamine Uptake Inhibitors Phase 4
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
28 Antidepressive Agents Phase 4
29 Antidepressive Agents, Second-Generation Phase 4
30 Antiemetics Phase 4,Phase 3,Phase 2
31 Autonomic Agents Phase 4,Phase 3,Phase 2
32
Teriparatide Approved, Investigational Phase 3,Phase 2 52232-67-4 16133850
33
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
34
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
35
Estradiol Approved, Investigational, Vet_approved Phase 2, Phase 3, Phase 1 50-28-2 5757
36
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
37
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078 2978
38
Etidronic acid Approved Phase 2, Phase 3 7414-83-7, 2809-21-4 3305
39
Levonorgestrel Approved, Investigational Phase 2, Phase 3 797-63-7, 17489-40-6 13109
40
Ethinyl Estradiol Approved Phase 2, Phase 3 57-63-6 5991
41
Medroxyprogesterone acetate Approved, Investigational Phase 2, Phase 3,Phase 1 71-58-9
42
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
43 Racepinephrine Approved Phase 2, Phase 3
44
Denosumab Approved Phase 3,Early Phase 1 615258-40-7
45
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
46
Dehydroepiandrosterone Approved, Nutraceutical Phase 2, Phase 3 53-43-0 9860744
47
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
48 tannic acid Approved, Nutraceutical Phase 3
49 Vitamins Phase 3
50 Bone Density Conservation Agents Phase 3,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 199)

id Name Status NCT ID Phase Drugs
1 A Double-blind, Placebo Controlled Trial of Risperidone for the Treatment of Anorexia Nervosa Completed NCT00140426 Phase 4 Risperidone;Placebo
2 Olanzapine in the Treatment of Anorexia Nervosa Completed NCT00592930 Phase 4 olanzapine;placebo
3 Fluoxetine to Prevent Relapse and Enhance Psychological Recovery in Women With Anorexia Nervosa Completed NCT00288574 Phase 4 Fluoxetine;Placebo
4 Effectiveness of Atypical Antipsychotic Medication for Outpatients With Anorexia Nervosa Completed NCT00685334 Phase 4 Olanzapine;Aripiprazole
5 Monoamine Contributions to Neurocircuitry in Eating Disorders Completed NCT02020408 Phase 4 [11C]raclopride;[11C]DASB;amphetamine
6 Does Hydroxyzine Decrease Anxiety in Underweight Patients Diagnosed With an Eating Disorder Withdrawn NCT01372670 Phase 4 Hydroxyzine;hydroxyzine HCL
7 ARIpiprazole in Anorexia NErvosa Unknown status NCT01082848 Phase 3 aripiprazole;placebo
8 The Efficacy of Readiness and Motivation Therapy in Individuals With Anorexia Nervosa and Bulimia Nervosa Unknown status NCT00220662 Phase 3
9 A Pilot Study to Evaluate the Effect of Forsteo (Teriparatide, 1-34-rh-PTH) in Anorexia Nervosa Patients With Low Bone Mineral Density and Increased Bone Fagility (FAN-Trial) Unknown status NCT01801397 Phase 3 osteoanabolic therapy
10 Effects of Anorexia Nervosa on Bone Mass in Adolescents Completed NCT00088153 Phase 2, Phase 3 Physiologic Estrogen/progesterone
11 Comparison of Two Types of Family Therapy in the Treatment of Adolescent Anorexia Nervosa Completed NCT00610753 Phase 3
12 Influence of Protein Supplements on Serum Insulin-like Growth Factor-I Levels in Women With Anorexia Nervosa Completed NCT01823822 Phase 2, Phase 3
13 Adrenal and Gonadal Hormone Replacement in Anorexia Nervosa Completed NCT00310791 Phase 2, Phase 3 Hormone replacement therapy (estrogen/progestin);Dehydroepiandrosterone (DHEA)
14 Bone Loss in Women With Anorexia Nervosa Completed NCT00089843 Phase 2, Phase 3 Testosterone;Actonel (risedronate);Placebo Actonel (risedronate);Placebo testosterone
15 The Role of Lactobacillus Reuteri in Children and Adolescents With Anorexia Nervosa Completed NCT02004288 Phase 2, Phase 3
16 Cannabinoid Receptor (CB1) Agonist Treatment in Severe Chronic Anorexia Nervosa Completed NCT00760695 Phase 3 dronabinol;placebo
17 Hormonal Therapy for Teens With Anorexia Nervosa Completed NCT01343771 Phase 3 DHEA (Prasterone) + ERT (Aviane)
18 Effects of Anorexia Nervosa on Peak Bone Mass Recruiting NCT01301183 Phase 3 RhIGF-1 with transdermal 17-beta estradiol;Placebo and transdermal 17-beta estradiol
19 Impact of Denosumab in the Prevention of Bone Loss in Non-menopausal Women With Anorexia Nervosa Recruiting NCT02567279 Phase 3 Denosumab subcutaneous injections;Placebo subcutaneous injections
20 Severe Decrease of Growth Velocity in Children With Anorexia Nervosa.Therapeutic Trial of Growth Hormone Recruiting NCT01626833 Phase 2, Phase 3 SOMATROPINE* : Norditropine® simplexx®
21 Evaluation of the Efficacy and Safety of Olanzapine for Anorexia Nervosa in Children and Adolescents Terminated NCT01184443 Phase 3 Olanzapine
22 Fatty Acids Omega -3 Diet Supplementation Efficiency and Safety Evaluation in Anorexia Nervosa Unknown status NCT01761942 Phase 2
23 Therapeutic Effects of Neurofeedback in Anorexia Nervosa Completed NCT01390493 Phase 1, Phase 2
24 A Relapse Prevention Program for Reducing Relapse and Fear of Food in People With Anorexia Nervosa Completed NCT00627341 Phase 1, Phase 2
25 Phase 2 Pilot Study to Evaluate the Safety and Efficacy of RM-131 Administered to Females With Anorexia Nervosa Completed NCT01642550 Phase 2 RM-131;Placebo
26 Treatment for Young Adults With Anorexia Nervosa Completed NCT01190423 Phase 1, Phase 2
27 Olanzapine in the Treatment of Patients With Anorexia Nervosa Completed NCT00260962 Phase 2 Olanzapine
28 The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa Completed NCT00759772 Phase 2 Placebo;Teriparatide
29 Effectiveness of Olanzapine Versus Placebo in Treating Outpatients With Anorexia Nervosa Completed NCT00692185 Phase 2 Olanzapine;Placebo
30 Effects of rhIGF-1 on Bone Metabolism in Adolescent Girls With Anorexia Nervosa Completed NCT00720122 Phase 2 Recombinant human insulin like growth factor-1 (rhIGF-1)
31 Comparing the Effectiveness of Three Types of Therapy for the Treatment of Anorexia Nervosa in Adolescents Completed NCT00183586 Phase 2
32 Effect of Growth Hormone on Bone Metabolism in Anorexia Nervosa Completed NCT00283595 Phase 2 Recombinant Human Growth Hormone;Placebo for Recombinant Human Growth Hormone
33 Hormonal Factors in the Treatment of Anorexia Nervosa Completed NCT01121211 Phase 2 Testosterone;Placebo
34 The Effect of Norgestimate/Ethinyl Estradiol on Bone Density in Pediatric Subjects With Anorexia Nervosa Completed NCT00320567 Phase 2 norgestimate/ethinyl estradiol
35 Safety Profile of Insulin Like Growth Factor-1 (IGF-I) Administration in Adolescents Completed NCT00516386 Phase 1, Phase 2 RhIGF-1
36 Amino Acids, Serotonin, and Body Weight Regulation Completed NCT00343928 Phase 2
37 Dissonance Inpatient Relapse Prevention Program for Anorexia Nervosa Recruiting NCT01611220 Phase 2
38 Treatment of Anxiety and Anorexia Nervosa in Adolescents Recruiting NCT01933243 Phase 2 Fish oil;Placebo pill
39 Transdermal Estrogen in Older Premenopausal Women With Anorexia Nervosa Recruiting NCT02475265 Phase 2 estradiol 0.045 mg/levonorgestrel 0.015mg
40 Estrogen Replacement in Anorexia Nervosa Recruiting NCT03172533 Phase 2 ethinyl estradiol 0.03mg and dienogest 2 mg (combination);Placebo oral capsule
41 A Double Blind, Placebo Controlled Trial of Quetiapine in Anorexia Nervosa, a Dual Site Study Terminated NCT00584688 Phase 2 quetiapine
42 The Effect of Testosterone Replacement on Bone Mineral Density in Boys and Men With Anorexia Nervosa Withdrawn NCT00853502 Phase 2 testosterone cypionate
43 Look at Food and Lose Your Fear - Evaluation of a Computerized Attention Training (CAT) for Anorexia Nervosa Patients Unknown status NCT02484599 Phase 1
44 Deep Brain Stimulation for the Treatment of Refractory Anorexia Nervosa Unknown status NCT01476540 Phase 1
45 Funen Anorexia Nervosa Study - Retrospective Cohort Study and 10 Year Follow-up Study Unknown status NCT00267228 Phase 1
46 Deep Brain Stimulation and Capsulotomy for the Treatment of Refractory Anorexia Nervosa Unknown status NCT01678014 Phase 1
47 Yoga in Treatment of Eating Disorders Unknown status NCT00870753 Phase 1
48 Effectiveness of Cognitive Remediation Therapy in Improving Treatment Retention in People With Anorexia Nervosa Completed NCT00601822 Phase 1
49 Family Treatment for Adolescents With Anorexia Nervosa Completed NCT01280799 Phase 1
50 Effectiveness of Family-Based Versus Individual Psychotherapy in Treating Adolescents With Anorexia Nervosa Completed NCT00149786 Phase 1

Search NIH Clinical Center for Anorexia Nervosa

Cochrane evidence based reviews: anorexia nervosa

Genetic Tests for Anorexia Nervosa

Genetic tests related to Anorexia Nervosa:

id Genetic test Affiliating Genes
1 Bulimia Nervosa 2 29

Anatomical Context for Anorexia Nervosa

MalaCards organs/tissues related to Anorexia Nervosa:

39
Bone, Brain, Heart, Testes, Liver, Pituitary, Lung

Publications for Anorexia Nervosa

Articles related to Anorexia Nervosa:

(show top 50) (show all 1362)
id Title Authors Year
1
Treatment of Anorexia Nervosa: The Importance of Disease Progression in the Prognosis. ( 28926324 )
2017
2
Food portion size area mediates energy effects on expected anxiety in anorexia nervosa. ( 28089925 )
2017
3
Anorexia nervosa and childhood sexual abuse: Treatment outcomes of intensive enhanced cognitive behavioural therapy. ( 28927864 )
2017
4
A Pilot, Multicentre Pragmatic Randomised Trial to Explore the Impact of Carer Skills Training on Carer and Patient Behaviours: Testing the Cognitive Interpersonal Model in Adolescent Anorexia Nervosa. ( 28948663 )
2017
5
Deep brain stimulation in the bed nucleus of the stria terminalis and medial forebrain bundle in a patient with major depressive disorder and anorexia nervosa. ( 28469875 )
2017
6
Effects of Anorexia Nervosa on the Endocrine System. ( 28508601 )
2017
7
Genetics of Anorexia Nervosa. ( 28940168 )
2017
8
Geriatric Anorexia Nervosa. ( 28923819 )
2017
9
Reexamining the Role of Electroconvulsive Therapy in Anorexia Nervosa in Adolescents. ( 28471772 )
2017
10
Advances in the treatment of anorexia nervosa: a review of established and emerging interventions. ( 28889819 )
2017
11
Heightened Olfactory Sensitivity in Young Females with Recent-Onset Anorexia Nervosa and Recovered Individuals. ( 28060877 )
2017
12
Commentary on Phillipou et al. (2017), Anorexia nervosa: Eating disorder or body image disorder? ( 28876079 )
2017
13
A focus on reward in anorexia nervosa through the lens of the activity-based anorexia (ABA) rodent model. ( 28475260 )
2017
14
Membranous tracheal stenosis in a patient with anorexia nervosa and self-induced vomiting- challenges in securing the airway. ( 28377879 )
2017
15
Anxiolytic effect of warmth in anorexia nervosa. ( 28043086 )
2017
16
A choroid plexus papilloma manifesting as anorexia nervosa in an adult. ( 28765434 )
2017
17
Low body mass index correlates with low left ventricular mass index in patients with severe anorexia nervosa. ( 28887668 )
2017
18
Adequacy of nutrient intake in women with restrictive anorexia nervosa. ( 28526387 )
2017
19
Affective temperaments in anorexia nervosa: The relevance of depressive and anxious traits. ( 28456073 )
2017
20
Outcomes of an inpatient refeeding protocol in youth with anorexia nervosa: Rady Children's Hospital San Diego/University of California, San Diego. ( 28053702 )
2017
21
The association between symptoms of autism and neuropsychological performance in females with Anorexia Nervosa. ( 28923433 )
2017
22
Symptom trajectories throughout two family therapy treatments for adolescent anorexia nervosa. ( 28913833 )
2017
23
A dark past, a restrained present, and an apocalyptic future: time perspective, personality, and life satisfaction among anorexia nervosa patients. ( 28929023 )
2017
24
Acute retropharyngeal abscess in a patient with anorexia nervosa. ( 28058633 )
2017
25
A comparison of the metabolic complications and hospital course of severe anorexia nervosa by binge-purge and restricting subtypes. ( 28060579 )
2017
26
Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: shedding light on the darkness. ( 28762842 )
2017
27
Nephrocalcinosis in a young male with anorexia nervosa. ( 28669007 )
2017
28
Assessment of Sex Differences in Body Composition Among Adolescents With Anorexia Nervosa. ( 28087266 )
2017
29
Transition Care in Anorexia Nervosa Through Guidance Online from Peer and Carer Expertise (TRIANGLE): Study Protocol for a Randomised Controlled Trial. ( 28944595 )
2017
30
Depictive and metric body size estimation in anorexia nervosa and bulimia nervosa: A systematic review and meta-analysis. ( 28818670 )
2017
31
Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. ( 28494655 )
2017
32
Serum kisspeptin concentrations are negatively correlated with body mass index in adolescents with anorexia nervosa and amenorrhea. ( 28500826 )
2017
33
Hepatic Complications of Anorexia Nervosa. ( 28932925 )
2017
34
Anorexia nervosa and bulimia nervosa: A meta-analysis of executive functioning. ( 28851577 )
2017
35
Plasma BDNF levels and anxiety in women with recovery from anorexia nervosa. ( 28522315 )
2017
36
Relationship of body weight with gastrointestinal motor and sensory function: studies in anorexia nervosa and obesity. ( 28056812 )
2017
37
Lesson of the month 2: A choroid plexus papilloma manifesting as anorexia nervosa in an adult. ( 28365635 )
2017
38
Influence of visceral interoceptive experience on the brain's response to food images in anorexia nervosa. ( 28498277 )
2017
39
Treatment with granulocyte colony-stimulating factor in the refeeding phase of anorexia nervosa complicated with severe neutropenia and sepsis: a case report. ( 28871553 )
2017
40
Comparing effects: a reanalysis of two studies on season of birth bias in anorexia nervosa. ( 28078085 )
2017
41
Long-Term Follow-up Study of MRI-Guided Bilateral Anterior Capsulotomy in Patients With Refractory Anorexia Nervosa. ( 28945886 )
2017
42
Body composition in men with anorexia nervosa: Longitudinal study. ( 28457012 )
2017
43
Computerized assessment of body image in anorexia nervosa and bulimia nervosa: comparison with standardized body image assessment tool. ( 27796596 )
2017
44
The role of pride in women with anorexia nervosa: A grounded theory study. ( 28467686 )
2017
45
Differences in Neural Responses to Reward and Punishment Processing between Anorexia Nervosa Subtypes: An fMRI Study. ( 28459134 )
2017
46
Risk of being convicted of theft and other crimes in anorexia nervosa and bulimia nervosa: A prospective cohort study in a Swedish female population. ( 28791709 )
2017
47
An Adolescent Male With Anorexia Nervosa Favorably Responded to Mirtazapine. ( 28504977 )
2017
48
Themes arising in clinical consultation for therapists implementing family-based treatment for adolescents with anorexia nervosa: a qualitative study. ( 28878927 )
2017
49
A child with anorexia nervosa presenting with severe infection with cytopenia and hemophagocytosis: a case report. ( 28878816 )
2017
50
Metasynthesis of the Views about Treatment of Anorexia Nervosa in Adolescents: Perspectives of Adolescents, Parents, and Professionals. ( 28056106 )
2017

Variations for Anorexia Nervosa

ClinVar genetic disease variations for Anorexia Nervosa:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 BDNF NM_170735.5(BDNF): c.196G> A (p.Val66Met) single nucleotide variant protective,risk factor rs6265 GRCh37 Chromosome 11, 27679916: 27679916

Expression for Anorexia Nervosa

Search GEO for disease gene expression data for Anorexia Nervosa.

Pathways for Anorexia Nervosa

Pathways related to Anorexia Nervosa according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CCK CRH GH1 GHR GHRH GHRL
2
Show member pathways
12.29 GH1 LEP LEPR PRL
3
Show member pathways
12.23 ADIPOQ IGF1 LEP LEPR
4
Show member pathways
12.03 GH1 GHRL IGF1 LEP POMC
6
Show member pathways
11.96 GH1 GHR LEP LEPR PRL
7 11.78 ADIPOQ GH1 IGF1 LEP RETN
8 11.68 ADIPOQ IGF1 LEP
9 11.48 GH1 GHR IGF1
10 11.33 LEP LEPR PRL
11
Show member pathways
11.22 GH1 GHR PRL
12
Show member pathways
11.06 LEP LEPR POMC
13 10.94 ADIPOQ AGRP LEP LEPR NPY POMC
14 10.78 AGRP POMC
15 10.32 CRH POMC

GO Terms for Anorexia Nervosa

Cellular components related to Anorexia Nervosa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ADIPOQ AGRP CCK CRH GH1 GHR
2 neuronal cell body GO:0043025 9.65 AGRP CCK CRH GHR HTR2A
3 extracellular region GO:0005576 9.55 ADIPOQ AGRP BDNF CCK CRH GH1
4 endosome lumen GO:0031904 9.32 GH1 PRL
5 growth hormone receptor complex GO:0070195 9.16 GH1 GHR

Biological processes related to Anorexia Nervosa according to GeneCards Suite gene sharing:

(show all 47)
id Name GO ID Score Top Affiliating Genes
1 response to estradiol GO:0032355 9.88 GH1 LEP SLC6A4
2 response to nutrient GO:0007584 9.86 ADIPOQ LEP SLC6A4
3 movement of cell or subcellular component GO:0006928 9.86 IGF1 NPY PYY
4 response to insulin GO:0032868 9.85 AGRP LEP RETN
5 regulation of blood pressure GO:0008217 9.85 LEP NPY POMC
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.83 GH1 IGF1 LEP
7 glucose metabolic process GO:0006006 9.83 ADIPOQ GHRL LEP
8 neuropeptide signaling pathway GO:0007218 9.83 AGRP NPY POMC PYY
9 feeding behavior GO:0007631 9.79 AGRP NPY PYY
10 female pregnancy GO:0007565 9.78 COMT CRH LEP PRL
11 circadian rhythm GO:0007623 9.76 ADIPOQ AGRP LEP SLC6A4
12 hormone-mediated signaling pathway GO:0009755 9.74 AGRP GHR GHRL
13 glucose homeostasis GO:0042593 9.73 ADIPOQ LEP LEPR
14 regulation of multicellular organism growth GO:0040014 9.72 GHR IGF1 PRL
15 eating behavior GO:0042755 9.71 AGRP CCK LEP
16 energy reserve metabolic process GO:0006112 9.7 LEP LEPR
17 negative regulation of gluconeogenesis GO:0045721 9.7 ADIPOQ LEPR
18 insulin-like growth factor receptor signaling pathway GO:0048009 9.69 GHR IGF1
19 central nervous system neuron development GO:0021954 9.69 LEP NPY
20 behavior GO:0007610 9.69 HTR2A NPY
21 sexual reproduction GO:0019953 9.68 LEP LEPR
22 regulation of feeding behavior GO:0060259 9.68 AGRP LEPR
23 leptin-mediated signaling pathway GO:0033210 9.67 LEP LEPR
24 positive regulation of growth hormone secretion GO:0060124 9.66 GHRH GHRL
25 negative regulation of appetite GO:0032099 9.66 CCK LEP
26 growth hormone receptor signaling pathway GO:0060396 9.65 GH1 GHR
27 response to nutrient levels GO:0031667 9.64 ADIPOQ LEP
28 growth hormone secretion GO:0030252 9.64 GHRH GHRL
29 regulation of bone remodeling GO:0046850 9.63 LEP LEPR
30 positive regulation of corticotropin secretion GO:0051461 9.62 CRH GHRL
31 bone mineralization involved in bone maturation GO:0035630 9.62 IGF1 LEP
32 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.61 GH1 GHR PRL
33 positive regulation of appetite GO:0032100 9.6 GHRL NPY
34 positive regulation of cortisol secretion GO:0051464 9.59 CRH GHRL
35 negative regulation of glucagon secretion GO:0070093 9.58 CRH LEP
36 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 GH1 GHR IGF1
37 positive regulation of multicellular organism growth GO:0040018 9.56 GH1 GHR GHRH GHRL
38 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.54 GH1 GHRH IGF1
39 negative regulation of circadian sleep/wake cycle, REM sleep GO:0042322 9.51 CRH GHRL
40 regulation of appetite GO:0032098 9.5 NPY POMC PYY
41 bone growth GO:0098868 9.49 LEP LEPR
42 positive regulation of JAK-STAT cascade GO:0046427 9.46 GH1 GHR LEP PRL
43 positive regulation of feeding behavior GO:2000253 9.33 AGRP
44 adult feeding behavior GO:0008343 9.26 AGRP GHRL LEP NPY
45 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.1 ADIPOQ CCK GH1 GHR HTR2A IGF1
46 positive regulation of cell proliferation GO:0008284 10.06 CCK CRH GHRH HTR2A IGF1 LEP
47 response to drug GO:0042493 10 ADIPOQ COMT CRH HTR2A SLC6A4

Molecular functions related to Anorexia Nervosa according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.73 ADIPOQ AGRP CRH LEP NPY POMC
2 growth factor activity GO:0008083 9.71 BDNF GH1 IGF1 LEP
3 G-protein coupled receptor binding GO:0001664 9.46 GHRL NPY POMC PYY
4 hormone activity GO:0005179 9.4 ADIPOQ CCK CRH GH1 GHRL IGF1
5 prolactin receptor binding GO:0005148 9.37 GH1 PRL
6 neuropeptide hormone activity GO:0005184 9.35 AGRP CCK CRH NPY PYY
7 growth hormone-releasing hormone activity GO:0016608 9.32 GHRH GHRL

Sources for Anorexia Nervosa

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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