Anosmia malady

Wikipedia: Anosmia (pronounced /ænˈɒzmiə/) is the inability to perceive odor, or in other words a lack of...⁴⁴ more...

MalaCards: Anosmia is related to kallmann syndrome and kallmann syndrome 1. An important gene associated with Anosmia is ANIC (Anosmia, isolated congenital), and among its related pathways is G alpha (q) signalling events. The compound forskolin have been mentioned in the context of this disorder. Affiliated tissues include temporal lobe, and related mouse phenotypes are vision/eye and endocrine/exocrine gland.

anosmia 7

Diseases related to anosmia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 52)

id	Related Disease	Score	Top Affiliating Genes
1	kallmann syndrome	28.9	PROKR2, GNRHR, XG, FGFR1, FGF8, KAL1
2	kallmann syndrome 1	27.6	KAL1, FGFR1
3	delayed puberty	26.8	GNRHR, FGFR1
4	x-linked ichthyosis	26.6	XG, KAL1
5	hypogonadotropism	26.5	FGFR1, GNRHR, PROKR2, XG, KAL1, FGF8
6	hypogonadism	26.5	FGF8, KAL1, XG, PROKR2, CHD7, FGFR1
7	ichthyosis	25.8	PHYH, KAL1, PEX7, XG
8	neuronitis	20.6	IFNA1, GNRHR, PROKR2, PHYH, PROK2, FGFR1
9	charge syndrome	13.2	KAL1, CHD7
10	infectious mononucleosis	13.1	FGFR1, FGF8
11	joubert syndrome and related disorders	13.1	CEP290, NPHP1
12	rhizomelic chondrodysplasia punctata type 2	13.1	PHYH, PEX7
13	rhizomelic chondrodysplasia punctata	13.1	PHYH, PEX7
14	peroxisomal disease	12.9	PHYH, PEX7
15	aorta atresia	12.8	CHD7, GNRHR
16	klinefelter's syndrome	12.8	GNRHR, FGFR1, CHD7
17	early-onset ataxia with oculomotor apraxia and hypoalbuminemia	12.8	NPHP1, CEP290
18	coloboma	12.7	CHD7, NPHP1, CEP290
19	polydactyly	12.7	FGF8, NPHP1, CEP290
20	cryptorchidism	12.6	GNRHR, FGFR1, KAL1, PROKR2
21	infantile refsum disease	12.4	PEX7, PHYH
22	gonadotropin deficiency	12.4	KAL1, FGFR1, PROKR2, PROK2, GNRHR
23	cerebellar ataxia	12.3	PHYH, PEX7, NPHP1
24	rhyns syndrome	12.3	PEX7, NPHP1, CEP290, PHYH
25	chondrodysplasia punctata	12.3	XG, PHYH, PEX7
26	tooth agenesis	12.2	FGFR1, PROKR2, FGF8, CHD7, PROK2, KAL1
27	renal agenesis	12.2	FGF8, FGFR1, PROK2, CHD7, KAL1, PROKR2
28	stickler syndrome	12.2	PROKR2, KAL1, FGFR1, PROK2, FGF8, CHD7
29	cleft lip	12.2	PROK2, FGFR1, KAL1, CHD7, PROKR2, FGF8
30	hyperparathyroidism	12.2	NPHP1, KAL1, FGFR1, SDHB
31	chondrodysplasia	11.7	PEX7, XG, PHYH, FGFR1, ADCY4
32	neuropathy	11.4	SCN9A, IFNA1, PHYH, PEX7, FGFR1
33	retinitis	10.9	CEP290, IFNA1, PEX7, NPHP1, FGFR1, PHYH
34	thyroiditis	10.9	PROKR2, NPHP1, SDHB, FGFR1, IFNA1, FGF8
35	congenital anosmia	8.1
36	hypogonadotropic hypogonadism without anosmia, x-linked	6.1
37	hypogonadotropic hypogonadism 13 with or without anosmia	6.1
38	hypogonadotropic hypogonadism 9 with or without anosmia	6.1
39	kallmann syndrome 4	6.1
40	refsum disease	6.1
41	cerebritis	5.2
42	hepatitis c	5.2
43	hepatitis	5.2
44	hereditary sensory neuropathy	5.2
45	isolated gonadotropin-releasing hormone (gnrh) deficiency	5.2
46	johnson neuroectodermal syndrome	5.2
47	kallmann syndrome 2	5.2
48	kallmann syndrome 3	5.2
49	kallmann syndrome 5	5.2
50	kallmann syndrome 6	5.2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to anosmia:

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MGI Mouse Phenotypes related to anosmia:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	vision/eye phenotype	MP:0005391	8.4	NPHP1, FGFR1, FGF8, CEP290, CHD7, PEX7
2	endocrine/exocrine gland phenotype	MP:0005379	8.0	PEX7, NPHP1, PROKR2, GNRHR, FGFR1, FGF8
3	reproductive system phenotype	MP:0005389	7.8	CHD7, PEX7, NPHP1, PROKR2, PHYH, GNRHR
4	nervous system phenotype	MP:0003631	7.1	PEX7, PROKR2, PROK2, PHYH, FGFR1, FGF8

Articles related to anosmia:

(show all 11)

id	Title	Authors	Year	Affiliating Genes
1	Loss-of-function mutations in sodium channel Nav1.7 c ause anosmia. (21441906)	Weiss J.... Zufall F.	2011	SCN9A
2	Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the selective loss of G proteins in cilia of olfactory sensory neurons. (17898177)	McEwen D.P.... Martens J.R.	2007	NPHP1, CEP290
3	Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia. (16882753)	Trarbach E.B.... Latronico A.C.	2006	FGFR1, KAL1
4	Isolated gonadotropic deficiency with and without anosmia: a developmental defect or a neuroendocrine regulation abnormality of the gonadotropic axis. (16286771)	de Roux N.	2005	FGFR1, GNRHR, KAL1
5	Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene. (15613419)	Pitteloud N.... Crowley W.F.	2005	FGFR1
6	Isolated congenital anosmia locus maps to 18p11.23-q12.2. (15060109)	Ghadami M.... Yoshiura K.	2004	ANIC
7	Zinc sulphate-induced anosmia decreases the nerve fib re density in the anterior cerebral artery of the rat. (11775698)	van Denderen J.C.... Bleys R.L.	2001	SDHB
8	Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. (11055432)	Wong S.T.... Storm D.R.	2000	ADCY4
9	Interferon-induced anosmia in a patient with chronic hepatitis C. (9448193)	Maruyama S.... Nakamoto M.	1998	IFNA1
10	Definitive localization of X-linked Kallman syndrome (hypogonadotropic hypogonadism and anosmia) to Xp22.3: close linkage to the hypervariable repeat sequence CRI-S232. (1977309)	Meitinger T.... Ballabio A.	1990	KAL1
11	X-linked ichthyosis, due to steroid sulphatase deficiency, associated with Kallmann syndrome (hypogonadotropic hypogonadism and anosmia): linkage relationships with Xg and cloned DNA sequences from the distal short arm of the X chromosome. (3007328)	Ballabio A.... Andria G.	1986	XG

Genes related to anosmia according to GeneCards:

(show all 17)

id	Symbol	Description	Score	GeneCards Section Context
1	ANIC	Anosmia, isolated congenital	11.1	Publications, Aliases & Descriptions
2	PROK2	prokineticin 2	11.0
3	ADCY4	adenylate cyclase 4	11.0	Publications
4	PROKR2	prokineticin receptor 2	11.0
5	KAL1	Kallmann syndrome 1 sequence	11.0	Publications
6	PHYH	phytanoyl-CoA 2-hydroxylase	11.0
7	FGF8	fibroblast growth factor 8 (androgen-induced)	11.0
8	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
9	PEX7	peroxisomal biogenesis factor 7	11.0
10	NPHP1	nephronophthisis 1 (juvenile)	11.0	Publications
11	CEP290	centrosomal protein 290kDa	11.0	Publications
12	CHD7	chromodomain helicase DNA binding protein 7	11.0
13	GNRHR	gonadotropin-releasing hormone receptor	11.0	Publications
14	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0	Publications
15	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	11.0	Publications
16	XG	Xg blood group	11.0	Publications
17	IFNA1	interferon, alpha 1	11.0	Publications

Pathways related to anosmia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	G alpha (q) signalling events38	9.6	GNRHR, PROK2, PROKR2

Compounds related to anosmia according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	forskolin32 42 9 9	12.2	FGF8, FGFR1, GNRHR, ADCY4

Cellular components related to anosmia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	photoreceptor connecting cilium	GO:032391	9.8	CEP290, NPHP1

Biological processes related to anosmia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	otic vesicle formation	GO:030916	9.8	CEP290, FGF8
2	branching involved in salivary gland morphogenesis	GO:060445	9.8	FGFR1, FGF8
3	fibroblast growth factor receptor signaling pathway	GO:008543	9.7	FGF8, FGFR1, ADCY4
4	organ induction	GO:001759	9.6	FGF8, FGFR1
5	retina development in camera-type eye	GO:060041	9.4	CHD7, CEP290, NPHP1