MCID: ANV001
MIFTS: 40

Anovulation malady

Reproductive diseases category
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Summaries for Anovulation

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65Wikipedia, 33MalaCards
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Wikipedia:65 An anovulatory cycle is a menstrual cycle during which the ovaries do not release an oocyte. Therefore,... more...

MalaCards: Anovulation is related to infertility and hyperandrogenism. An important gene associated with Anovulation is CGA (glycoprotein hormones, alpha polypeptide), and among its related pathways are Hormone ligand-binding receptors and Peptide hormone metabolism. The compounds altrenogest and deslorelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and breast.

Aliases & Classifications for Anovulation

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

anovulation 8 10 45 62


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Disease Ontology8 DOID:3781
NCIt40 C34388
SNOMED-CT58 34571000
MeSH35 D000858

Related Diseases for Anovulation

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17GeneCards, 18GeneDecks
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Diseases related to Anovulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1infertility30.7CYP21A2, GNRH1, SHBG, CGA
2hyperandrogenism30.7CGA, SHBG, GNRH1, CYP21A2
3polycystic ovary syndrome30.7CYP21A2, GNRH1, SHBG, GHRL, CGA
4amenorrhea30.7GNRH1, SHBG
5obesity30.4GHRL, SHBG, CYP21A2
6endometriosis30.3CGA, GNRH1
7ovarian disease30.2CGA, SHBG, GNRH1
8hyperprolactinemia30.2GNRH1, SHBG, CGA
9breast cancer30.2GHRL, SHBG, GNRH1
10insulin resistance30.1GHRL, SHBG, CYP21A2
11ovarian cyst30.0GNRH1, CGA
12pregnancy loss30.0CGA, GNRH1
13hypothyroidism29.9SHBG, CGA
14pituitary adenoma29.9CGA, GHRL, GNRH1
15glucose intolerance29.9GHRL, SHBG
16endometrial carcinoma29.9SHBG, GNRH1
17hyperinsulinism29.9GHRL, SHBG, GNRH1
18adenoma29.7CGA, GHRL, SHBG, GNRH1, CYP21A2
19vaginitis10.3
20blindness10.3
21diabetes mellitus10.1
22acne10.1SHBG
23alopecia10.1SHBG
24hypothalamic disease10.1GNRH1, CGA
25penis agenesis10.1CGA, GNRH1
26ovarian hyperstimulation syndrome10.0CGA, GNRH1
27aorta atresia10.0GNRH1, CGA
28oligospermia10.0CGA, GNRH1
29abrikosov's tumor10.0GNRH1, CGA
30kallmann syndrome10.0GNRH1, CGA
31luteoma10.0CGA, CYP21A2
32germinoma10.0CGA, CYP21A2
33prolactinoma10.0GNRH1, CGA
34hypospadias10.0CGA, CYP21A2
35adrenal gland hyperfunction10.0CYP21A2, GHRL
36congenital adrenal hyperplasia10.0GNRH1, CYP21A2
37autoimmune thyroiditis10.0GHRL, CYP21A2
38androgen insensitivity syndrome10.0SHBG, CGA
39pituitary tumors10.0GNRH1, GHRL
40sexual disorder10.0GNRH1, SHBG
41celiac disease10.0GHRL, CYP21A2
42hypoglycemia10.0GHRL, GNRH1
43premature ovarian failure10.0GNRH1, SHBG
44testicular cancer10.0CGA, SHBG
45androgenic alopecia10.0SHBG, CYP21A2
46acanthosis nigricans10.0SHBG, CYP21A2
47anorexia nervosa10.0SHBG, GHRL
48bronchitis10.0GHRL, SHBG
49male infertility10.0SHBG, GNRH1
50leydig cell tumor10.0CYP21A2, GNRH1, CGA

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to anovulation

Symptoms for Anovulation

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Drugs & Therapeutics for Anovulation

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Anovulation

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Anatomical Context for Anovulation

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33MalaCards
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MalaCards organs/tissues related to Anovulation:

33
Ovary, Pituitary, Breast, Testes, Brain

Animal Models for Anovulation or affiliated genes

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Publications for Anovulation

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52PubMed
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Articles related to Anovulation:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
Pregnancy complications and metabolic disease in women with clomiphene citrate-resistant anovulation randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotropins: a 10-year follow-up. (24268702)
2014
2
British Fertility Society. 'Ovulation induction in WHO Type 1 anovulation: Guidelines for practice'. Produced on behalf of the BFS Policy and Practice Committee. (24245485)
2013
3
Progestogens with or without oestrogen for irregular uterine bleeding associated with anovulation. (22972055)
2012
4
Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares. (21571458)
2011
5
Detection of anovulation by heatmount detectors and transrectal ultrasonography before treatment with progesterone in a timed insemination protocol. (18565948)
2008
6
Does metformin modify ovarian responsiveness during exogenous FSH ovulation induction in normogonadotrophic anovulation? A placebo-controlled double-blind assessment. (15817918)
2005
7
Oral anti-oestrogens and medical adjuncts for subfertility associated with anovulation. (15674894)
2005
8
A randomized clinical trial of treatment of clomiphene citrate-resistant anovulation with the use of oral contraceptive pill suppression and repeat clomiphene citrate treatment. (12824973)
2003
9
The effectiveness and safety of recombinant human LH to support follicular development induced by recombinant human FSH in WHO group I anovulation: evidence from a multicentre study in Spain. (11726569)
2001
10
Lactational amenorrhea/anovulation and some of their determinants: a comparison of well-nourished and undernourished women. (11476779)
2001
11
Nutritionally induced anovulation in beef Heifers: ovarian and endocrine function during realimentation and resumption of ovulation. (10775198)
2000
12
New hyperprolactinemia and anovulation model in common marmoset (Callithrix jacchus) and effect of cabergoline. (10096770)
1999
13
Extended clomiphene citrate (CC) and prednisone for the treatment of chronic anovulation resistant to CC alone. (9093187)
1997
14
Women with functional hypothalamic amenorrhea but not other forms of anovulation display amplified cortisol concentrations. (9176439)
1997
15
The effect of alprazolam on serum cortisol and luteinizing hormone pulsatility in normal women and in women with stress-related anovulation. (7883836)
1995
16
Lactational anovulation in non-human primates: restriction of nursing inhibits Prl secretion without precipitating the return of ovulatory menstrual cyclicity in cynomolgus monkeys. (7796594)
1995
17
A comparative prospective study of conventional regimen with chronic low-dose administration of follicle-stimulating hormone for anovulation associated with polycystic ovary syndrome. (7890055)
1995
18
Chronic anovulation due to prolactin hypersecretion. (7900499)
1994
19
Postpartum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. (1619032)
1992
20
Atmospheric temperature & anovulation in south Indian women with primary infertility. (1597328)
1992
21
The association of anovulation and endometriosis in the infertile female. (2619687)
1989
22
The effects of an aromatase inhibitor and a 5 alpha-reductase inhibitor upon the occurrence of polyovular follicles, persistent anovulation, and permanent vaginal stratification in mice treated neonatally with testosterone. (3196799)
1988
23
Endometrial carcinoma following chronic anovulation in a premenopausal woman with systemic lupus erythematosus. (3239388)
1988
24
Changing pituitary reactivity to follicle-stimulating hormone and luteinizing hormone-releasing hormone after induced ovulatory cycles and after anovulation in patients with polycystic ovarian disease. (3119650)
1987
25
Circadian variations of luteinizing hormone can have two different profiles in adolescent anovulation. (3114303)
1987
26
Effects of intermittent injections of LHRH on secretory patterns of LH and FSH and ovarian follicular growth during postpartum anovulation in suckled beef cows. (3087926)
1986
27
Anovulation in postpartum suckled beef cows. II. Associations among binding of 125I-labeled gonadotropins to granulosa and thecal cells, and concentrations of steroids in serum and various sized ovarian follicles. (3009380)
1986
28
Anovulation in postpartum suckled beef cows. I. Associations among size and numbers of ovarian follicles, uterine involution, and hormones in serum and follicular fluid. (3700270)
1986
29
Pulsatile gonadotropin secretion in women with hypothalamic amenorrhea: evidence that reduced frequency of gonadotropin-releasing hormone secretion is the mechanism of persistent anovulation. (3900122)
1985
30
Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase. (6423124)
1984
31
Anovulation in female rats induced by neonatal administration of the catechol estrogens, 2-hydroxy-estradiol and 4-hydroxy-estradiol. (6196675)
1983
32
Prevention of continuous light-induced anovulation in rats by early exposure to continuous light. (6640025)
1983
33
Anovulation and oviductal hyperplasia in rats treated with clomiphene citrate 5 days after birth. (532522)
1979
34
Use of bromocriptine in hyperprolactinaemic anovulation and related disorders. (378649)
1979
35
Etiology of anovulation in the immature alloxan-diabetic rat treated with pregnant mare's serum gonadotropin: absence of the preovulatory luteinizing hormone surge. (744054)
1978
36
Kepone, mirex, dieldrin, and aldrin: estrogenic activity and the induction of persistent vaginal estrus and anovulation in rats following neonatal treatment. (79483)
1978
37
Anovulation and increased androgenic activity as breast cancer risk in women with fibrocystic disease of the breast. (679211)
1978
38
Endometriosis and anovulation: a coexisting problem in the infertile female. (1275031)
1976
39
Serum corticosterone in rats with delayed anovulation. (988105)
1976
40
An assessment of urinary and plasma steroid estimations for monitoring treatment of anovulation with gonadotrophins. (4411958)
1974
41
The effect of intravenous synthetic luteinizing hormone releasing hormone (LHRH) in infertile women with anovulation. (4601472)
1974
42
Results of treatment of longstanding oligomenorrhea and persistent anovulation with clomiphene citrate. (4795075)
1973
43
Anovulation. What price fertility? (5073459)
1972
44
Clinical results with human gonadotrophins in anovulation, using two alternative dosage schemes. (5014975)
1972
45
Treatment of anovulation in the Stein-Leventhal syndrome. Analysis of 90 cases. (5548552)
1971
46
Syndrome of anovulation following the oral contraceptives. (4951888)
1967
47
Clinical effects of clomiphene in anovulation. (5925037)
1966
48
ANOVULATION. (14180863)
1964
49
The problem of anovulation in private practice. (13538780)
1958
50
A survey of general and ovarian sterility with special reference to anovulation. (20250327)
1947

Variations for Anovulation

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Expression for genes affiliated with Anovulation

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anovulation

Search GEO for disease gene expression data for Anovulation.

Pathways for genes affiliated with Anovulation

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Anovulation

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Anovulation according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1altrenogest459.9GNRH1, CGA
2deslorelin459.8GNRH1, CGA
3metrodin459.8CGA, GNRH1
4pergonal459.8CGA, GNRH1
5antarelix45 2910.8GNRH1, CGA
6ganirelix45 2910.7CGA, GNRH1
7d-trp6-lhrh459.6CGA, GNRH1
8epitestosterone459.5CGA, SHBG
9naloxone45 29 51 1112.3CGA, GNRH1, GHRL
10nafarelin45 61 29 1112.3CYP21A2, GNRH1, CGA
11opiate459.3CGA, GHRL, GNRH1
12goserelin45 29 1111.1CGA, GNRH1, SHBG
13flutamide45 61 1111.1GNRH1, SHBG, CGA
14bromocriptine45 29 1111.0CGA, GNRH1, SHBG
15diethylstilbestrol45 29 1111.0GNRH1, SHBG, CGA
16cyproteroneacetate459.0GHRL, SHBG, GNRH1
1717-hydroxypregnenolone459.0SHBG, CYP21A2, CGA
1811 deoxycortisol459.0CYP21A2, SHBG, CGA
19triiodothyronine458.9CGA, SHBG, GHRL
20phenytoin45 51 29 1111.9CGA, SHBG, CYP21A2
21spironolactone45 61 29 51 1112.9CYP21A2, SHBG, GNRH1
22progestin458.9CGA, GNRH1, SHBG
23c-peptide458.8CYP21A2, GHRL, SHBG
24dhea458.8CYP21A2, SHBG, GHRL
25mifepristone45 29 61 1111.8GNRH1, CGA, SHBG
26ribonucleic acid458.7CGA, GNRH1, CYP21A2, GHRL
27metformin45 51 1110.6GHRL, SHBG, CGA, GNRH1
28leuprolide acetate458.5CGA, SHBG, GNRH1, CYP21A2
29clomiphene citrate458.5CGA, SHBG, GNRH1, CYP21A2
3017-hydroxyprogesterone45 249.5CGA, SHBG, GNRH1, CYP21A2
31androstenedione45 249.5CYP21A2, GNRH1, SHBG, CGA
32dihydrotestosterone45 29 24 1111.5SHBG, CGA, CYP21A2, GNRH1
33lactate458.4GHRL, CGA, SHBG, GNRH1
34hydrocortisone45 3 61 1111.4CYP21A2, SHBG, GHRL
35dopamine45 29 24 1111.4SHBG, GNRH1, CGA, GHRL
36acth458.4CYP21A2, SHBG, GHRL, GNRH1
37creatinine458.4CGA, GNRH1, GHRL, SHBG
38adenylate458.3GHRL, CGA, GNRH1, SHBG
39progesterone45 29 61 24 1112.1CGA, GNRH1, SHBG, CYP21A2
40dexamethasone45 51 29 1111.0GHRL, SHBG, GNRH1, CYP21A2
41dehydroepiandrosterone sulfate458.0CGA, GHRL, SHBG, CYP21A2, GNRH1
42thyroxine45 249.0SHBG, GHRL, CGA, GNRH1, CYP21A2
43gnrh458.0GHRL, CYP21A2, GNRH1, CGA, SHBG
44epinephrine45 24 1110.0CGA, SHBG, GHRL, GNRH1, CYP21A2
45norepinephrine45 24 1110.0SHBG, GHRL, CGA, GNRH1, CYP21A2
46estradiol45 24 1110.0CGA, GHRL, SHBG, GNRH1, CYP21A2
47testosterone45 61 24 1110.9GHRL, SHBG, GNRH1, CYP21A2, CGA
48arginine457.9GHRL, CGA, CYP21A2, GNRH1, SHBG
49estrogen457.9CGA, GHRL, GNRH1, SHBG, CYP21A2
50steroid457.8SHBG, GNRH1, CYP21A2, CGA

GO Terms for genes affiliated with Anovulation

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16Gene Ontology
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Cellular components related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2CGA, GHRL, SHBG, GNRH1

Molecular functions related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5CGA, GNRH1

Products for genes affiliated with Anovulation

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Sources for Anovulation

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet