MCID: ANV001
MIFTS: 40

Anovulation malady

Reproductive diseases category
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Summaries for Anovulation

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Wikipedia:65 An anovulatory cycle is a menstrual cycle during which the ovaries do not release an oocyte. Therefore,... more...

MalaCards based summary: Anovulation is related to amenorrhea and endometriosis. An important gene associated with Anovulation is CGA (glycoprotein hormones, alpha polypeptide), and among its related pathways are Hormone ligand-binding receptors and Peptide hormone metabolism. The compounds altrenogest and deslorelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and breast.

Aliases & Classifications for Anovulation

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
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Anovulation, Aliases & Descriptions:

Name: Anovulation 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:3781
MeSH34 D000858
SNOMED-CT57 34571000
NCIt39 C34388

Related Diseases for Anovulation

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Diseases related to Anovulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1amenorrhea30.7GNRH1, SHBG
2endometriosis30.4GNRH1, CGA
3hyperandrogenism30.3CGA, GNRH1, CYP21A2, SHBG
4infertility30.3GNRH1, CYP21A2, SHBG, CGA
5ovarian cyst30.3GNRH1, CGA
6pregnancy loss30.2CGA, GNRH1
7ovarian disease30.1SHBG, GNRH1, CGA
8hyperprolactinemia30.1GNRH1, SHBG, CGA
9obesity30.1CYP21A2, SHBG, GHRL
10polycystic ovary syndrome30.1GHRL, CGA, SHBG, GNRH1, CYP21A2
11hypothyroidism30.0SHBG, CGA
12insulin resistance29.9CYP21A2, SHBG, GHRL
13pituitary adenoma29.9CGA, GHRL, GNRH1
14breast cancer29.9GNRH1, SHBG, GHRL
15glucose intolerance29.9GHRL, SHBG
16endometrial carcinoma29.8GNRH1, SHBG
17hyperinsulinism29.7GHRL, SHBG, GNRH1
18hypogonadism29.4GHRL, GNRH1, SHBG, CGA
19adenoma29.0CYP21A2, GNRH1, SHBG, GHRL, CGA
20vaginitis10.3
21acne10.3SHBG
22blindness10.3
23alopecia10.3SHBG
24hypothalamic disease10.2GNRH1, CGA
25penis agenesis10.2CGA, GNRH1
26ovarian hyperstimulation syndrome10.2CGA, GNRH1
27aorta atresia10.2GNRH1, CGA
28oligospermia10.2CGA, GNRH1
29abrikosov's tumor10.2GNRH1, CGA
30kallmann syndrome10.2CGA, GNRH1
31luteoma10.2CGA, CYP21A2
32germinoma10.2CYP21A2, CGA
33prolactinoma10.2CGA, GNRH1
34hypospadias10.1CGA, CYP21A2
35adrenal gland hyperfunction10.1GHRL, CYP21A2
36congenital adrenal hyperplasia10.1CYP21A2, GNRH1
37diabetes mellitus10.1
38autoimmune thyroiditis10.1GHRL, CYP21A2
39androgen insensitivity syndrome10.1SHBG, CGA
40pituitary tumors10.1GNRH1, GHRL
41sexual disorder10.1GNRH1, SHBG
42celiac disease10.1GHRL, CYP21A2
43hypoglycemia10.1GHRL, GNRH1
44premature ovarian failure10.1SHBG, GNRH1
45testicular cancer10.0CGA, SHBG
46androgenetic alopecia10.0CYP21A2, SHBG
47acanthosis nigricans10.0CYP21A2, SHBG
48anorexia nervosa10.0SHBG, GHRL
49non-suppurative otitis media10.0SHBG, GHRL
50male infertility10.0SHBG, GNRH1

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to anovulation

Symptoms for Anovulation

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Drugs & Therapeutics for Anovulation

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Drug clinical trials:

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Genetic Tests for Anovulation

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Anatomical Context for Anovulation

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MalaCards organs/tissues related to Anovulation:

32
Ovary, Pituitary, Breast, Testes, Brain

Animal Models for Anovulation or affiliated genes

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Publications for Anovulation

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Articles related to Anovulation:

(show top 50)    (show all 301)
idTitleAuthorsYear
1
Accounting for Anovulation and Vaginal Thinning During Depot Medroxyprogesterone Acetate Use. (25217405)
2014
2
British Fertility Society. 'Ovulation induction in WHO Type 1 anovulation: Guidelines for practice'. Produced on behalf of the BFS Policy and Practice Committee. (24245485)
2013
3
Progestogens with or without oestrogen for irregular uterine bleeding associated with anovulation. (22972055)
2012
4
Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares. (21571458)
2011
5
Detection of anovulation by heatmount detectors and transrectal ultrasonography before treatment with progesterone in a timed insemination protocol. (18565948)
2008
6
Does metformin modify ovarian responsiveness during exogenous FSH ovulation induction in normogonadotrophic anovulation? A placebo-controlled double-blind assessment. (15817918)
2005
7
Oral anti-oestrogens and medical adjuncts for subfertility associated with anovulation. (15674894)
2005
8
A randomized clinical trial of treatment of clomiphene citrate-resistant anovulation with the use of oral contraceptive pill suppression and repeat clomiphene citrate treatment. (12824973)
2003
9
The effectiveness and safety of recombinant human LH to support follicular development induced by recombinant human FSH in WHO group I anovulation: evidence from a multicentre study in Spain. (11726569)
2001
10
Lactational amenorrhea/anovulation and some of their determinants: a comparison of well-nourished and undernourished women. (11476779)
2001
11
Nutritionally induced anovulation in beef Heifers: ovarian and endocrine function during realimentation and resumption of ovulation. (10775198)
2000
12
New hyperprolactinemia and anovulation model in common marmoset (Callithrix jacchus) and effect of cabergoline. (10096770)
1999
13
Extended clomiphene citrate (CC) and prednisone for the treatment of chronic anovulation resistant to CC alone. (9093187)
1997
14
Women with functional hypothalamic amenorrhea but not other forms of anovulation display amplified cortisol concentrations. (9176439)
1997
15
The effect of alprazolam on serum cortisol and luteinizing hormone pulsatility in normal women and in women with stress-related anovulation. (7883836)
1995
16
Lactational anovulation in non-human primates: restriction of nursing inhibits Prl secretion without precipitating the return of ovulatory menstrual cyclicity in cynomolgus monkeys. (7796594)
1995
17
A comparative prospective study of conventional regimen with chronic low-dose administration of follicle-stimulating hormone for anovulation associated with polycystic ovary syndrome. (7890055)
1995
18
Postpartum lactational anovulation in a nonhuman primate (Macaca fascicularis): endogenous opiate mediation of suckling-induced hyperprolactinemia. (1619032)
1992
19
Gonadotropin releasing hormone loading test with bromocryptin therapy: a new possibility in the differential diagnosis of normo-prolactinaemic anovulation]. (1625857)
1992
20
Atmospheric temperature & anovulation in south Indian women with primary infertility. (1597328)
1992
21
The association of anovulation and endometriosis in the infertile female. (2619687)
1989
22
The effects of an aromatase inhibitor and a 5 alpha-reductase inhibitor upon the occurrence of polyovular follicles, persistent anovulation, and permanent vaginal stratification in mice treated neonatally with testosterone. (3196799)
1988
23
Endometrial carcinoma following chronic anovulation in a premenopausal woman with systemic lupus erythematosus. (3239388)
1988
24
Changing pituitary reactivity to follicle-stimulating hormone and luteinizing hormone-releasing hormone after induced ovulatory cycles and after anovulation in patients with polycystic ovarian disease. (3119650)
1987
25
Circadian variations of luteinizing hormone can have two different profiles in adolescent anovulation. (3114303)
1987
26
Effects of intermittent injections of LHRH on secretory patterns of LH and FSH and ovarian follicular growth during postpartum anovulation in suckled beef cows. (3087926)
1986
27
Anovulation in postpartum suckled beef cows. II. Associations among binding of 125I-labeled gonadotropins to granulosa and thecal cells, and concentrations of steroids in serum and various sized ovarian follicles. (3009380)
1986
28
Anovulation in postpartum suckled beef cows. I. Associations among size and numbers of ovarian follicles, uterine involution, and hormones in serum and follicular fluid. (3700270)
1986
29
Pulsatile gonadotropin secretion in women with hypothalamic amenorrhea: evidence that reduced frequency of gonadotropin-releasing hormone secretion is the mechanism of persistent anovulation. (3900122)
1985
30
Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase. (6423124)
1984
31
Anovulation in female rats induced by neonatal administration of the catechol estrogens, 2-hydroxy-estradiol and 4-hydroxy-estradiol. (6196675)
1983
32
Prevention of continuous light-induced anovulation in rats by early exposure to continuous light. (6640025)
1983
33
Anovulation and oviductal hyperplasia in rats treated with clomiphene citrate 5 days after birth. (532522)
1979
34
Use of bromocriptine in hyperprolactinaemic anovulation and related disorders. (378649)
1979
35
Etiology of anovulation in the immature alloxan-diabetic rat treated with pregnant mare's serum gonadotropin: absence of the preovulatory luteinizing hormone surge. (744054)
1978
36
Kepone, mirex, dieldrin, and aldrin: estrogenic activity and the induction of persistent vaginal estrus and anovulation in rats following neonatal treatment. (79483)
1978
37
Anovulation and increased androgenic activity as breast cancer risk in women with fibrocystic disease of the breast. (679211)
1978
38
Endometriosis and anovulation: a coexisting problem in the infertile female. (1275031)
1976
39
Serum corticosterone in rats with delayed anovulation. (988105)
1976
40
An assessment of urinary and plasma steroid estimations for monitoring treatment of anovulation with gonadotrophins. (4411958)
1974
41
The effect of intravenous synthetic luteinizing hormone releasing hormone (LHRH) in infertile women with anovulation. (4601472)
1974
42
Results of treatment of longstanding oligomenorrhea and persistent anovulation with clomiphene citrate. (4795075)
1973
43
Anovulation. What price fertility? (5073459)
1972
44
Clinical results with human gonadotrophins in anovulation, using two alternative dosage schemes. (5014975)
1972
45
Treatment of anovulation in the Stein-Leventhal syndrome. Analysis of 90 cases. (5548552)
1971
46
Syndrome of anovulation following the oral contraceptives. (4951888)
1967
47
Clinical effects of clomiphene in anovulation. (5925037)
1966
48
ANOVULATION. (14180863)
1964
49
The problem of anovulation in private practice. (13538780)
1958
50
A survey of general and ovarian sterility with special reference to anovulation. (20250327)
1947

Variations for Anovulation

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Expression for genes affiliated with Anovulation

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Expression patterns in normal tissues for genes affiliated with Anovulation

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Pathways for genes affiliated with Anovulation

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Compounds for genes affiliated with Anovulation

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Compounds related to Anovulation according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1altrenogest449.9GNRH1, CGA
2deslorelin449.8GNRH1, CGA
3metrodin449.8CGA, GNRH1
4pergonal449.8CGA, GNRH1
5antarelix44 2810.8GNRH1, CGA
6ganirelix44 2810.7CGA, GNRH1
7d-trp6-lhrh449.6CGA, GNRH1
8epitestosterone449.5CGA, SHBG
9naloxone44 28 50 1112.3CGA, GNRH1, GHRL
10nafarelin44 61 28 1112.3CYP21A2, GNRH1, CGA
11opiate449.3CGA, GHRL, GNRH1
12goserelin44 28 1111.1CGA, GNRH1, SHBG
13flutamide44 61 1111.1GNRH1, SHBG, CGA
14bromocriptine44 28 1111.0CGA, GNRH1, SHBG
15diethylstilbestrol44 28 1111.0GNRH1, SHBG, CGA
16cyproteroneacetate449.0GHRL, SHBG, GNRH1
1717-hydroxypregnenolone449.0SHBG, CYP21A2, CGA
1811 deoxycortisol449.0CYP21A2, SHBG, CGA
19triiodothyronine448.9CGA, SHBG, GHRL
20phenytoin44 50 28 1111.9CGA, SHBG, CYP21A2
21spironolactone44 61 28 50 1112.9CYP21A2, SHBG, GNRH1
22progestin448.9CGA, GNRH1, SHBG
23c-peptide448.8CYP21A2, GHRL, SHBG
24dhea448.8CYP21A2, SHBG, GHRL
25mifepristone44 28 61 1111.8GNRH1, CGA, SHBG
26ribonucleic acid448.7CGA, GNRH1, CYP21A2, GHRL
27metformin44 50 1110.6GHRL, SHBG, CGA, GNRH1
28leuprolide acetate448.5CGA, SHBG, GNRH1, CYP21A2
29clomiphene citrate448.5CGA, SHBG, GNRH1, CYP21A2
3017-hydroxyprogesterone44 249.5CGA, SHBG, GNRH1, CYP21A2
31androstenedione44 249.5CYP21A2, GNRH1, SHBG, CGA
32dihydrotestosterone44 28 24 1111.5SHBG, CGA, CYP21A2, GNRH1
33lactate448.4GHRL, CGA, SHBG, GNRH1
34hydrocortisone44 2 61 1111.4CYP21A2, SHBG, GHRL
35dopamine44 28 24 1111.4SHBG, GNRH1, CGA, GHRL
36acth448.4CYP21A2, SHBG, GHRL, GNRH1
37creatinine448.4CGA, GNRH1, GHRL, SHBG
38adenylate448.3GHRL, CGA, GNRH1, SHBG
39progesterone44 28 61 24 1112.1CGA, GNRH1, SHBG, CYP21A2
40dexamethasone44 50 28 1111.0GHRL, SHBG, GNRH1, CYP21A2
41dehydroepiandrosterone sulfate448.0CGA, GHRL, SHBG, CYP21A2, GNRH1
42thyroxine44 249.0SHBG, GHRL, CGA, GNRH1, CYP21A2
43gnrh448.0GHRL, CYP21A2, GNRH1, CGA, SHBG
44epinephrine44 24 1110.0CGA, SHBG, GHRL, GNRH1, CYP21A2
45norepinephrine44 24 1110.0SHBG, GHRL, CGA, GNRH1, CYP21A2
46estradiol44 24 1110.0CGA, GHRL, SHBG, GNRH1, CYP21A2
47testosterone44 61 24 1110.9GHRL, SHBG, GNRH1, CYP21A2, CGA
48arginine447.9GHRL, CGA, CYP21A2, GNRH1, SHBG
49estrogen447.9CGA, GHRL, GNRH1, SHBG, CYP21A2
50steroid447.8SHBG, GNRH1, CYP21A2, CGA

GO Terms for genes affiliated with Anovulation

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Cellular components related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2CGA, GHRL, SHBG, GNRH1

Molecular functions related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5CGA, GNRH1

Products for genes affiliated with Anovulation

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Sources for Anovulation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet