MCID: ANV001
MIFTS: 48

Anovulation malady

Summaries for Anovulation

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 An anovulatory cycle is a menstrual cycle during which the ovaries do not release an oocyte. Therefore,... more...

MalaCards: Anovulation is related to polycystic ovary syndrome and infertility. An important gene associated with Anovulation is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are Development Prolactin receptor signaling and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, brain and breast, and related mouse phenotypes are adipose tissue and integument.

Aliases & Classifications for Anovulation

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

anovulation 8 10 45 61


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Disease Ontology8 DOID:3781
NCIt40 C34388
SNOMED-CT57 34571000
MeSH35 D000858

Related Diseases for Anovulation

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anovulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome30.8SRD5A1, FSHR, LEP, INS, CYP21A2, CYP19A1
2infertility30.7SULT2A1, FSHB, FSHR, LEP, INS, CYP21A2
3amenorrhea30.6SULT2A1, FSHR, LEP, INS, TRH, IGF1
4hyperprolactinemia30.2SRD5A1, TRH, IGF1, SHBG, PRL, CGA
5hyperandrogenism30.2SRD5A1, SULT2A1, FSHR, LEP, INS, CYP21A2
6insulin resistance30.1LEP, INS, CYP21A2, IGF1, IGFBP3, IGFBP1
7systemic lupus erythematosus29.9PRL
8diabetes insipidus29.9TRH, PRL
9glucose intolerance29.9LEP, INS, IGF1, IGFBP3, IGFBP1, SHBG
10hyperinsulinism29.9LEP, INS, CYP21A2, IGF1, IGFBP3, IGFBP1
11adenoma29.8SRD5A1, SULT2A1, FSHB, FSHR, INS, CYP21A2
12n syndrome10.2
13mccune albright syndrome10.0GNRH1
14prostatic hypertrophy10.0GNRH1
15acne10.0SHBG
16alopecia10.0SHBG
17down syndrome10.0CGA
18uterine fibroid10.0GNRH1
19prostatitis10.0SRD5A1
20hepatitis10.0IGFBP1
21acute myocardial infarction10.0IGFBP1
22blindness10.0INS
23leukemia10.0IGFBP1
24borderline personality disorder10.0CGA
25aromatase deficiency10.0CYP19A1
26placental insufficiency10.0IGFBP1
27pancreatitis10.0INS
28hypoactive sexual desire disorder10.0SHBG
29hypogonadotropism10.0PRL, GNRH1
30lung cancer10.0IGF1
31hermaphroditism10.0AMH
32ileus10.0GHRL
33cystic fibrosis10.0INS
34testicular cancer10.0SHBG, CGA
35congenital hypothyroidism10.0CYP21A2
36leiomyoma10.0CYP19A1, GNRH1
37conduct disorder10.0CGA
38germinoma10.0CYP21A2, CGA
39myeloma10.0IGF1
40goiter10.0TRH
41acquired generalized lipodystrophy10.0LEP
42dementia10.0TRH
43fibromyalgia10.0CRH
44celiac disease10.0CYP21A2, GHRL
45multiple myeloma10.0IGF1
46marasmus10.0IGFBP3
47panhypopituitarism10.0IGF1, PRL
48penile disease10.0PRL, GNRH1
49arthritis10.0LEP, GHRL
50luteoma10.0CYP21A2, CGA

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to anovulation

Clinical Features for Anovulation

Drugs & Therapeutics for Anovulation

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Anovulation

Drug clinical trials:

Search ClinicalTrials for Anovulation

Search NIH Clinical Center for Anovulation

Search CenterWatch for Anovulation

Genetic Tests for Anovulation

Anatomical Context for Anovulation

Sources:
33MalaCards
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MalaCards organs/tissues related to Anovulation:

33
Ovary, Brain, Breast, T cells, Fetal brain, Pituitary

Animal Models for Anovulation or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Anovulation

Sources:
51PubMed
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Articles related to Anovulation:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
British Fertility Society. 'Ovulation induction in WHO Type 1 anovulation: Guidelines for practice'. Produced on behalf of the BFS Policy and Practice Committee. (24245485)
2013
2
Risk factors and effects of postpartum anovulation in dairy cows. (22459832)
2012
3
Cornual polyps of the fallopian tube are associated with endometriosis and anovulation. (22190955)
2012
4
Anovulation with or without PCO, hyperandrogenaemia and hyperinsulinaemia as promoters of endometrial and breast cancer. (19264556)
2010
5
Body shape and size and insulin resistance as early clinical predictors of hyperandrogenic anovulation in ethnic minority adolescent girls. (18639784)
2008
6
Ovulation disorders: Part II. Anovulation associated with normal estrogen. (17629155)
2007
7
Association of increased total antioxidant capacity and anovulation in nonobese infertile patients with clomiphene citrate-resistant polycystic ovary syndrome. (17303132)
2007
8
The use of a decremental dose regimen in patients treated with a chronic low-dose step-up protocol for WHO Group II anovulation: a prospective randomized multicentre study. (16877376)
2006
9
Anovulation and ovulation induction. (20351807)
2006
10
Does metformin modify ovarian responsiveness during exogenous FSH ovulation induction in normogonadotrophic anovulation? A placebo-controlled double-blind assessment. (15817918)
2005
11
Oral anti-oestrogens and medical adjuncts for subfertility associated with anovulation. (15674894)
2005
12
Anovulation in the prevention of cytotoxic-induced follicular attrition and ovarian failure. (15033951)
2004
13
Anovulation. (12958117)
2003
14
Gonadotropin therapy for the treatment of anovulation and for ovarian hyperstimulation for IVF. (11900890)
2002
15
Anovulation in eumenorrheic, nonobese adolescent girls born small for gestational age: insulin sensitization induces ovulation, increases lean body mass, and reduces abdominal fat excess, dyslipidemia, and subclinical hyperandrogenism. (12466374)
2002
16
Frequency of anovulation and early menopause among women enrolled in selected adult AIDS clinical trials group studies. (11679923)
2001
17
Changes in leptin levels during lactation: implications for lactational hyperphagia and anovulation. (10860679)
2000
18
Twice daily suckling but not milking with calf presence prolongs postpartum anovulation. (10462001)
1999
19
Urinary follicle-stimulating hormone (FSH) versus recombinant FSH in clomiphene citrate-resistant, normogonadotropic,chronic anovulation: a prospective randomized study. (10438995)
1999
20
Extended clomiphene citrate (CC) and prednisone for the treatment of chronic anovulation resistant to CC alone. (9093187)
1997
21
Chronic anovulation due to prolactin hypersecretion. (7900499)
1994
22
Postpartum anovulation in non-nursing monkeys: hypothalamic-pituitary-ovarian refractoriness is not induced by the milieu of early pregnancy. (7932643)
1994
23
Treatment of anovulation with pulsatile gonadotropin-releasing hormone: prognostic factors and clinical results in 600 cycles. (7962297)
1994
24
Testosterone, a follicular regulator: key to anovulation. (8370694)
1993
25
Increased luteinizing hormone and alpha-subunit secretion in women with hyperandrogenic anovulation. (7691863)
1993
26
Atmospheric temperature & anovulation in south Indian women with primary infertility. (1597328)
1992
27
Induced anovulation as treatment of premenstrual tension syndrome. A double-blind cross-over study with GnRH-agonist versus placebo. (3140572)
1988
28
Modern approaches to the diagnosis and management of anovulation. (2904416)
1988
29
Changing pituitary reactivity to follicle-stimulating hormone and luteinizing hormone-releasing hormone after induced ovulatory cycles and after anovulation in patients with polycystic ovarian disease. (3119650)
1987
30
Effects of intermittent injections of LHRH on specific binding of 125I-labeled gonadotropins to granulosa and theca, and concentrations of steroids in serum and ovarian follicles during postpartum anovulation in suckled beef cows. (3522520)
1986
31
Ovarian multifollicularity, high LH and androgen plasma levels, and anovulation are frequent and strongly linked in adolescent irregular cycles. (3515820)
1986
32
Low-dose corticoid therapy for anovulation: effect upon fetal weight. (7121912)
1982
33
Menstrual cycle changes with marathon training: anovulation and short luteal phase. (7127652)
1982
34
Primary hyperprolactinaemia and chronic anovulation: pathophysiology and management. (6226352)
1982
35
Estrogen-androgen balance in anovulation. (7195829)
1981
36
Anovulation and oviductal hyperplasia in rats treated with clomiphene citrate 5 days after birth. (532522)
1979
37
Hypothyroidism and anovulation. (86746)
1979
38
Plasma hormone profile in anovulation. (571358)
1979
39
Hypothalamic chronic anovulation. (147631)
1978
40
Treatment of hyperprolactinemia-anovulation syndrome. (562780)
1977
41
Endometriosis and anovulation: a coexisting problem in the infertile female. (1275031)
1976
42
Treatment of anovulation with human menopausal gonadotrophin. (1265551)
1976
43
Management of anovulation. (4620625)
1974
44
Anovulation. What price fertility? (5073459)
1972
45
A possible process of the secondary sterilization: delayed anovulation syndrome. (5104053)
1971
46
Human menopausal gonadotropins for anovulation and sterility. Results of 7 years of treatment. (6023499)
1967
47
ANOVULATION IN HOSPITALIZED MENTAL PATIENTS. (14329170)
1965
48
The diagnostic and therapeutic use of intravenous estrogen in anovulation. (13501268)
1958
49
Roentgen therapy in anovulation and sterility. (13277540)
1956
50
Diagnosis and treatment of infertility due to anovulation. (21025738)
1946

Genetic Variations for Anovulation

Expression for genes affiliated with Anovulation

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anovulation

Search GEO for disease gene expression data for Anovulation.

Pathways for genes affiliated with Anovulation

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 52QIAGEN
See all sources

Pathways related to Anovulation according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Prolactin receptor signaling
Hide members
10.0PRL, INS
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.8CGA, IGF1, CYP19A1
39.8IGF1, IGFBP3, IGFBP1
49.8IGFBP1, IGFBP3, IGF1
59.8LEP, INS, PRL
6
Hide members
9.7SRD5A1, CYP21A2, CYP19A1
7
Hide members
9.6GNRH1, CGA, FSHR, FSHB
89.6CGA, CYP19A1, FSHR, FSHB
9
Hide members
9.5CGA, GHRL, INS, FSHB
10
Hide members
9.4FSHB, FSHR, CGA, CRH
11
Hide members
9.3INS, IGF1, PRL, BMP15, GNRH1
129.3FSHB, LEP, INS, IGFBP1, CGA
13
Hide members
8.9CGA, GHRL, IGFBP1, IGFBP3, IGF1, INS
148.8FSHB, BMP15, CGA, IGF1, CYP19A1, INS
15
Hide members
8.2GNRH1, CRH, CGA, GHRL, PRL, TRH
16
Hide members
7.9GNRH1, CRH, CGA, GHRL, PRL, IGF1

Compounds for genes affiliated with Anovulation

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
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Compounds related to Anovulation according to GeneCards/GeneDecks:

(show top 50)    (show all 214)
idCompoundScoreTop Affiliating Genes
1estrogen4510.0TRH, SRD5A1
2goserelin45 29 1111.8SRD5A1, GNRH1, CGA
3norepinephrine45 11 2411.8CYP21A2, TRH, PRL, CGA, GNRH1
4oxandrolone45 1110.6SHBG, IGFBP3, IGF1, GHRL, INS
511 deoxycortisol459.5CGA, CRH, SHBG, CYP21A2, PRL
6leuprolide45 60 29 1112.5IGF1, PRL, CGA, GNRH1, SRD5A1
7letrozole45 50 60 1112.5IGFBP3, LEP, CYP19A1, SHBG, IGF1, CGA
8bromocriptine29 45 1111.4SHBG, CGA, PRL, IGFBP3, TRH, GNRH1
9flutamide45 60 1111.4CGA, SRD5A1, CYP19A1, SHBG, PRL, GNRH1
10levonorgestrel45 60 29 1112.3SHBG, PRL, IGFBP1, IGFBP3, SRD5A1, CYP19A1
11ghrp459.3IGF1, PRL, IGFBP3, GHRL, TRH
12cyproteroneacetate459.3SRD5A1, INS, CYP19A1, SHBG, PRL, GHRL
13leuprolide acetate459.3CGA, GNRH1, PRL, SHBG, IGF1, FSHB
14megestrol acetate459.3SHBG, IGFBP3, IGF1, CYP19A1, LEP
15hexarelin45 2910.2IGF1, PRL, GHRL, CRH, IGFBP3
16anastrozole45 1110.2IGFBP3, SHBG, CGA, CYP19A1, IGFBP1
17buserelin45 29 1111.2FSHB, CYP19A1, IGF1, IGFBP3, IGFBP1, PRL
18progestins459.1SHBG, IGFBP1, IGFBP3, CYP19A1, SRD5A1, GNRH1
19c-peptide459.1GHRL, SHBG, CYP21A2, IGFBP1, INS, IGFBP3
20cortisone45 2410.0INS, LEP, SRD5A1, CYP21A2, IGF1, CRH
21metformin45 50 1111.0IGF1, IGFBP1, SHBG, GHRL, CGA, GNRH1
22pyridostigmine45 1110.0TRH, IGF1, IGFBP3, IGFBP1, PRL, GHRL
23mifepristone45 60 29 1112.0AMH, CYP19A1, IGFBP1, CRH, SHBG, PRL
24naloxone45 50 29 1112.0CRH, GNRH1, TRH, GHRL, CGA, PRL
25progestin458.9SRD5A1, CYP19A1, IGF1, IGFBP3, IGFBP1, SHBG
2617-hydroxyprogesterone45 249.8PRL, CGA, CRH, GNRH1, SHBG, IGFBP1
27dopamine45 29 11 2411.7SRD5A1, IGF1, SHBG, GHRL, GNRH1, TRH
28dexamethasone45 50 29 1111.7GNRH1, SULT2A1, INS, CYP21A2, TRH, SHBG
29epinephrine45 11 2410.7CRH, CGA, GHRL, LEP, INS, CYP21A2
30octreotide45 60 29 1111.6INS, TRH, IGF1, IGFBP3, IGFBP1, PRL
31triiodothyronine458.5PRL, GHRL, CGA, SHBG, IGFBP1, IGFBP3
32estrone45 29 11 2411.5SHBG, PRL, GNRH1, IGFBP1, IGFBP3, IGF1
33dihydrotestosterone45 29 11 2411.4IGFBP3, CYP19A1, IGF1, SRD5A1, LEP, CYP21A2
34creatinine458.4IGFBP3, IGF1, INS, LEP, IGFBP1, CRH
35ribonucleic acid458.4FSHB, FSHR, CYP21A2, IGF1, IGFBP3, IGFBP1
36tamoxifen45 50 29 1111.4GNRH1, AMH, SULT2A1, LEP, CYP19A1, IGF1
37hydrocortisone45 2 60 1111.4CRH, GHRL, INS, CYP21A2, CYP19A1, TRH
38dehydroepiandrosterone sulfate458.4SRD5A1, SULT2A1, CYP19A1, IGFBP3, IGFBP1, CYP21A2
39vitamin d458.2CRH, SRD5A1, SULT2A1, CYP19A1, IGF1, IGFBP1
40clomiphene citrate458.2GNRH1, CRH, CGA, PRL, FSHB, INS
41gnrh458.0IGFBP1, SHBG, GHRL, CGA, GNRH1, SRD5A1
42thyroxine45 248.8IGFBP1, SHBG, PRL, GHRL, CGA, CRH
43acth457.8SULT2A1, FSHB, LEP, CYP21A2, TRH, IGF1
44estradiol45 11 249.7PRL, CGA, GNRH1, AMH, SRD5A1, SULT2A1
45dhea457.6IGF1, IGFBP3, IGFBP1, SHBG, PRL, GHRL
46androstenedione45 248.6CGA, CRH, GNRH1, PRL, SHBG, IGFBP1
47arginine457.5LEP, CRH, GNRH1, CGA, GHRL, INS
48steroid457.2LEP, CYP21A2, CYP19A1, IGF1, IGFBP3, IGFBP1
49progesterone45 60 29 11 2410.2SRD5A1, SULT2A1, FSHB, FSHR, LEP, CYP21A2
50testosterone45 60 11 248.9IGFBP1, SHBG, PRL, GHRL, CGA, CRH

GO Terms for genes affiliated with Anovulation

Sources:
16Gene Ontology
See all sources

Cellular components related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.0INS, GHRL
2insulin-like growth factor binding protein complexGO:0169429.7IGF1, IGFBP3
3extracellular spaceGO:0056157.8AMH, GNRH1, BMP15, CRH, GHRL, IGFBP1
4extracellular regionGO:0055766.9FSHB, AMH, GNRH1, CRH, CGA, GHRL

Biological processes related to Anovulation according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1bone mineralization involved in bone maturationGO:03563010.2LEP, IGF1
2ovulation cycleGO:04269810.2PRL, GNRH1
3prostate gland growthGO:06073610.2IGF1, CYP19A1
4follicle-stimulating hormone signaling pathwayGO:04269910.2FSHB, FSHR
5positive regulation of cortisol secretionGO:05146410.2CRH, GHRL
6negative regulation of circadian sleep/wake cycle, REM sleepGO:04232210.2CRH, GHRL
7positive regulation of insulin receptor signaling pathwayGO:04662810.2INS, LEP
8positive regulation of corticotropin secretionGO:05146110.1GHRL, CRH
9negative regulation of glucagon secretionGO:07009310.1CRH, LEP
10glucocorticoid biosynthetic processGO:00670410.1CYP21A2, CRH
11adult feeding behaviorGO:00834310.0LEP, GHRL
12female gamete generationGO:00729210.0BMP15, FSHR, FSHB
13parturitionGO:00756710.0CRH, PRL
14positive regulation of glycogen biosynthetic processGO:04572510.0INS, IGF1
15sex determinationGO:0075309.9SRD5A1, AMH
16positive regulation of glycolysisGO:0458219.9INS, IGF1
17positive regulation of MAPK cascadeGO:0434109.8LEP, INS, IGF1, IGFBP3
18positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.7IGF1, IGFBP3
19steroid metabolic processGO:0082029.7CYP19A1, CYP21A2, SULT2A1, SRD5A1
20response to ethanolGO:0454719.6GNRH1, CRH, PRL, TRH
21female pregnancyGO:0075659.6FSHB, LEP, PRL, CRH, GNRH1
22cell-cell signalingGO:0072679.4INS, TRH, CGA, GNRH1, AMH
23cellular protein metabolic processGO:0442679.2CGA, GHRL, IGFBP1, IGFBP3, IGF1, INS
24positive regulation of cell proliferationGO:0082849.2FSHB, LEP, INS, IGF1, CGA, CRH
25signal transductionGO:0071658.9GNRH1, CRH, CGA, IGFBP1, IGF1, TRH

Molecular functions related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.0IGF1, INS
2growth factor activityGO:0080839.1IGF1, BMP15, LEP, AMH
3hormone activityGO:0051798.1CGA, GNRH1, CRH, PRL, IGF1, INS

Products for genes affiliated with Anovulation

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Sources for Anovulation

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet