MCID: ANV001
MIFTS: 51

Anovulation malady

Summaries for Anovulation

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63Wikipedia, 32MalaCards
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Wikipedia:63 An anovulatory cycle is a menstrual cycle during which the ovaries do not release an oocyte. Therefore,... more...

MalaCards: Anovulation is related to polycystic ovary syndrome and infertility. An important gene associated with Anovulation is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are Development Prolactin receptor signaling and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and testes, and related mouse phenotypes are adipose tissue and integument.

Aliases & Classifications for Anovulation

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

anovulation 8 10 44 60


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Disease Ontology8 DOID:3781
NCIt39 C34388
SNOMED-CT56 34571000
MeSH34 D000858

Related Diseases for Anovulation

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17GeneCards, 18GeneDecks
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Diseases related to Anovulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome30.8SRD5A1, FSHR, LEP, INS, CYP21A2, CYP19A1
2infertility30.7SULT2A1, FSHB, FSHR, LEP, INS, CYP21A2
3hyperandrogenism30.7SRD5A1, SULT2A1, FSHR, LEP, INS, CYP21A2
4amenorrhea30.5SULT2A1, FSHR, LEP, INS, TRH, IGF1
5obesity30.3SRD5A1, FSHR, LEP, INS, CYP21A2, TRH
6endometriosis30.2FSHR, CYP19A1, IGFBP1, CGA, GNRH1
7ovarian disease30.2FSHR, CYP19A1, IGFBP1, SHBG, PRL, CGA
8breast cancer30.2SRD5A1, CYP19A1, IGFBP3, SHBG, GHRL, GNRH1
9hyperprolactinemia30.2SRD5A1, TRH, IGF1, SHBG, PRL, CGA
10down syndrome30.1CGA
11diabetes mellitus30.0LEP, INS, IGF1, IGFBP3, IGFBP1, SHBG
12systemic lupus erythematosus29.8PRL
13diabetes insipidus29.8TRH, PRL
14ovarian cyst29.8CYP19A1, CGA, GNRH1
15endometrial carcinoma29.8CYP19A1, IGFBP1, GNRH1
16ovarian cancer29.8FSHR, CYP19A1, IGFBP3, GNRH1
17hypothyroidism29.8FSHR, TRH, SHBG, CGA
18glucose intolerance29.8LEP, INS, IGF1, IGFBP3, IGFBP1, SHBG
19hyperinsulinism29.8LEP, INS, CYP21A2, IGF1, IGFBP3, IGFBP1
20pituitary adenoma29.8FSHB, FSHR, LEP, TRH, IGF1, PRL
21adenoma29.8SRD5A1, SULT2A1, FSHB, FSHR, INS, CYP21A2
22vaginitis10.2
23mccune albright syndrome10.0GNRH1
24prostatic hypertrophy10.0GNRH1
25acne10.0SHBG
26alopecia10.0SHBG
27uterine fibroid10.0GNRH1
28prostatitis10.0SRD5A1
29hepatitis10.0IGFBP1
30acute myocardial infarction10.0IGFBP1
31blindness10.0INS
32leukemia10.0IGFBP1
33borderline personality disorder10.0CGA
34aromatase deficiency10.0CYP19A1
35placental insufficiency10.0IGFBP1
36pancreatitis10.0INS
37hypoactive sexual desire disorder10.0SHBG
38hypogonadotropism10.0PRL, GNRH1
39lung cancer10.0IGF1
40hermaphroditism10.0AMH
41ileus10.0GHRL
42cystic fibrosis10.0INS
43testicular cancer10.0SHBG, CGA
44congenital hypothyroidism10.0CYP21A2
45leiomyoma10.0CYP19A1, GNRH1
46conduct disorder10.0CGA
47germinoma10.0CYP21A2, CGA
48myeloma10.0IGF1
49goiter10.0TRH
50acquired generalized lipodystrophy10.0LEP

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to anovulation

Clinical Features for Anovulation

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Drugs & Therapeutics for Anovulation

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Anovulation

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Anatomical Context for Anovulation

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32MalaCards
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MalaCards organs/tissues related to Anovulation:

32
Ovary, Pituitary, Testes, Breast, Brain

Animal Models for Anovulation or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anovulation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.0FSHR, CYP19A1, IGFBP3
2MP:00107719.5INS, GNRH1, CRH, FSHR
3MP:00053799.2AMH, BMP15, FSHR, FSHB, SRD5A1
4MP:00053709.1CYP19A1, IGFBP3, INS, LEP, PRL, GNRH1
5MP:00020068.8AMH, FSHR, LEP, IGF1, PRL, GNRH1
6MP:00053898.6CGA, PRL, FSHR, FSHB, SRD5A1, BMP15
7MP:00053878.4GNRH1, CRH, PRL, IGFBP1, IGF1, FSHR
8MP:00036317.9GNRH1, IGF1, FSHR, LEP, INS, CRH
9MP:00053787.8GNRH1, CGA, IGFBP3, IGF1, TRH, CYP19A1
10MP:00053767.1FSHR, FSHB, INS, TRH, CGA, GHRL

Publications for Anovulation

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50PubMed
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Articles related to Anovulation:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Loss of LH-induced down-regulation of anti-MA1llerian hormone receptor expression may contribute to anovulation in women with polycystic ovary syndrome. (23321213)
2013
2
Progestogens with or without oestrogen for irregular uterine bleeding associated with anovulation. (22972055)
2012
3
Aberrant follicle development and anovulation in polycystic ovary syndrome. (20362969)
2010
4
Association of genetic markers within the BMP15 gene with anovulation and infertility in women with polycystic ovary syndrome. (17905236)
2008
5
Continuous administration of low-dose GnRH in mares I. Control of persistent anovulation during the ovulatory season. (17482671)
2007
6
Progestogens versus oestrogens and progestogens for irregular uterine bleeding associated with anovulation. (17943761)
2007
7
PCOS according to the Rotterdam consensus criteria: Change in prevalence among WHO-II anovulation and association with metabolic factors. (16972863)
2006
8
Bayesian analysis of risk factors for anovulation. (15195323)
2004
9
Follicular development and hormone concentrations following recombinant FSH administration for anovulation associated with polycystic ovarian syndrome: prospective, randomized comparison between low-dose step-up and modified step-down regimens. (11278212)
2001
10
Does anovulation induced by oral contraceptives favor pregnancy during the following two menstrual cycles? (10731535)
2000
11
Changes in leptin levels during lactation: implications for lactational hyperphagia and anovulation. (10860679)
2000
12
Treatment of hyperprolactinemic anovulation with the dopamin-agonist quinagolide]. (10962898)
2000
13
Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant). (9022598)
1997
14
Laparoscopic surgery of chronic hyperandrogenic anovulation. (7791504)
1995
15
ACOG technical bulletin. Hyperandrogenic chronic anovulation. Number 202--February 1995. Committee on Technical Bulletins of the American College of Obstetricians and Gynecologists. (7649333)
1995
16
Hyperandrogenic anovulation (PCOS): a unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus. (7825639)
1995
17
Evidence that androgens are involved in atresia and anovulation induced by antiprogesterone RU486 in rats. (8283435)
1993
18
Post-partum anovulation in nursing mothers. (1791646)
1991
19
Spontaneous anovulation causing disappearance of cyclical symptoms in women with the premenstrual syndrome. (1897330)
1991
20
Pituitary gonadotropin responsiveness to repeated gonadotropin releasing hormone (GnRH) stimulations in patients with chronic anovulation. (1776504)
1991
21
Daily measurements of salivary progesterone reveal a high rate of anovulation in healthy students. (2740829)
1989
22
The effects of an aromatase inhibitor and a 5 alpha-reductase inhibitor upon the occurrence of polyovular follicles, persistent anovulation, and permanent vaginal stratification in mice treated neonatally with testosterone. (3196799)
1988
23
Endometrial carcinoma following chronic anovulation in a premenopausal woman with systemic lupus erythematosus. (3239388)
1988
24
Induced anovulation as treatment of premenstrual tension syndrome. A double-blind cross-over study with GnRH-agonist versus placebo. (3140572)
1988
25
Circadian variations of luteinizing hormone can have two different profiles in adolescent anovulation. (3114303)
1987
26
Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. (3094734)
1986
27
Influence of the frequency of gonadotropin-releasing hormone (GnRH) administration on ovulatory responses in women with anovulation. (3891425)
1985
28
Depressed prolactin levels in diabetic women with anovulation. (6818826)
1982
29
Incremental clomiphene therapy: a new method for treating persistent anovulation. (6795551)
1981
30
Altered neuroendocrine status of middle-aged rats prior to the onset of senescent anovulation. (514454)
1979
31
Anovulation treated with clomiphene. (437174)
1979
32
Etiology of anovulation in the immature alloxan-diabetic rat treated with pregnant mare's serum gonadotropin: absence of the preovulatory luteinizing hormone surge. (744054)
1978
33
Kepone, mirex, dieldrin, and aldrin: estrogenic activity and the induction of persistent vaginal estrus and anovulation in rats following neonatal treatment. (79483)
1978
34
Anovulation. (354866)
1978
35
Stimulation of follicular growth with "pure" FSH in patients with anovulation and elevated LH levels. (628528)
1978
36
The delayed anovulation syndrome: influence of hormones and correlation with behaviour. (925583)
1977
37
Bromocriptine for induction of ovulation in normoprolactinaemic post-pill anovulation. (65607)
1977
38
Post-pill anovulation. (1263979)
1976
39
Treatment of anovulation with human menopausal gonadotrophin. (1265551)
1976
40
Endocrine aspects of anovulation. (1197149)
1975
41
An assessment of urinary and plasma steroid estimations for monitoring treatment of anovulation with gonadotrophins. (4411958)
1974
42
The effect of intravenous synthetic luteinizing hormone releasing hormone (LHRH) in infertile women with anovulation. (4601472)
1974
43
Treatment of anovulation with synthetic luteinizing hormone-releasing hormone. (4576558)
1973
44
Anovulation or oligoovulation. Treatment--hazards and precautions. (5019105)
1972
45
Treatment of anovulation in the Stein-Leventhal syndrome. Analysis of 90 cases. (5548552)
1971
46
Metabolism of ovarian steroids in a patient with chronic familial anovulation. (4249817)
1970
47
Progress in the investigation and treatment of anovulation. (4885438)
1969
48
Pathogenesis of psychogenic amenorrhea and anovulation. (5842642)
1965
49
THE TREATMENT OF ANOVULATION BY HUMAN PITUITARY GONADOTROPHIN. (14157875)
1964
50
Irradiation in the treatment of anovulation. (13476950)
1957

Genetic Variations for Anovulation

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Expression for genes affiliated with Anovulation

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anovulation

Search GEO for disease gene expression data for Anovulation.

Pathways for genes affiliated with Anovulation

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN
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Pathways related to Anovulation according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Prolactin receptor signaling
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10.0INS, PRL
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.8CGA, IGF1, CYP19A1
39.8IGFBP1, IGF1, IGFBP3
49.8IGFBP3, IGFBP1, IGF1
59.8INS, LEP, PRL
6
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9.7CYP21A2, CYP19A1, SRD5A1
7
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9.6FSHB, FSHR, CGA, GNRH1
89.6CYP19A1, FSHR, FSHB, CGA
9
Hide members
9.5FSHB, INS, GHRL, CGA
10
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9.4FSHB, CGA, FSHR, CRH
11
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9.3GNRH1, PRL, IGF1, BMP15, INS
129.3LEP, IGFBP1, CGA, INS, FSHB
13
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8.9FSHB, CGA, GHRL, IGFBP1, IGFBP3, IGF1
148.8FSHR, INS, BMP15, CYP19A1, IGF1, CGA
15
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8.2PRL, GNRH1, TRH, FSHB, GHRL, CGA
16
Hide members
7.9GNRH1, CRH, CGA, GHRL, PRL, IGF1

Compounds for genes affiliated with Anovulation

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Anovulation according to GeneCards/GeneDecks:

(show top 50)    (show all 214)
idCompoundScoreTop Affiliating Genes
1estrogen4410.0TRH, SRD5A1
2goserelin44 28 1111.8SRD5A1, GNRH1, CGA
3norepinephrine44 11 2411.8CYP21A2, TRH, PRL, CGA, GNRH1
4oxandrolone44 1110.6SHBG, IGFBP3, IGF1, GHRL, INS
511 deoxycortisol449.5CGA, CRH, SHBG, CYP21A2, PRL
6leuprolide44 59 28 1112.5IGF1, PRL, CGA, GNRH1, SRD5A1
7letrozole44 49 59 1112.5IGFBP3, LEP, CYP19A1, SHBG, IGF1, CGA
8bromocriptine28 44 1111.4SHBG, CGA, PRL, IGFBP3, TRH, GNRH1
9flutamide44 59 1111.4CGA, SRD5A1, CYP19A1, SHBG, PRL, GNRH1
10levonorgestrel44 59 28 1112.3SHBG, PRL, IGFBP1, IGFBP3, SRD5A1, CYP19A1
11ghrp449.3IGF1, PRL, IGFBP3, GHRL, TRH
12cyproteroneacetate449.3SRD5A1, INS, CYP19A1, SHBG, PRL, GHRL
13leuprolide acetate449.3CGA, GNRH1, PRL, SHBG, IGF1, FSHB
14megestrol acetate449.3SHBG, IGFBP3, IGF1, CYP19A1, LEP
15hexarelin44 2810.2IGF1, PRL, GHRL, CRH, IGFBP3
16anastrozole44 1110.2IGFBP3, SHBG, CGA, CYP19A1, IGFBP1
17buserelin44 28 1111.2FSHB, CYP19A1, IGF1, IGFBP3, IGFBP1, PRL
18progestins449.1SHBG, IGFBP1, IGFBP3, CYP19A1, SRD5A1, GNRH1
19c-peptide449.1GHRL, SHBG, CYP21A2, IGFBP1, INS, IGFBP3
20cortisone44 2410.0INS, LEP, SRD5A1, CYP21A2, IGF1, CRH
21metformin44 49 1111.0IGF1, IGFBP1, SHBG, GHRL, CGA, GNRH1
22pyridostigmine44 1110.0TRH, IGF1, IGFBP3, IGFBP1, PRL, GHRL
23mifepristone44 59 28 1112.0AMH, CYP19A1, IGFBP1, CRH, SHBG, PRL
24naloxone44 49 28 1112.0CRH, GNRH1, TRH, GHRL, CGA, PRL
25progestin448.9SRD5A1, CYP19A1, IGF1, IGFBP3, IGFBP1, SHBG
2617-hydroxyprogesterone44 249.8PRL, CGA, CRH, GNRH1, SHBG, IGFBP1
27dopamine44 28 11 2411.7SRD5A1, IGF1, SHBG, GHRL, GNRH1, TRH
28dexamethasone44 49 28 1111.7GNRH1, SULT2A1, INS, CYP21A2, TRH, SHBG
29epinephrine44 11 2410.7CRH, CGA, GHRL, LEP, INS, CYP21A2
30octreotide44 59 28 1111.6INS, TRH, IGF1, IGFBP3, IGFBP1, PRL
31triiodothyronine448.5PRL, GHRL, CGA, SHBG, IGFBP1, IGFBP3
32estrone44 28 11 2411.5SHBG, PRL, GNRH1, IGFBP1, IGFBP3, IGF1
33dihydrotestosterone44 28 11 2411.4IGFBP3, CYP19A1, IGF1, SRD5A1, LEP, CYP21A2
34creatinine448.4IGFBP3, IGF1, INS, LEP, IGFBP1, CRH
35ribonucleic acid448.4FSHB, FSHR, CYP21A2, IGF1, IGFBP3, IGFBP1
36tamoxifen44 49 28 1111.4GNRH1, AMH, SULT2A1, LEP, CYP19A1, IGF1
37hydrocortisone44 2 59 1111.4CRH, GHRL, INS, CYP21A2, CYP19A1, TRH
38dehydroepiandrosterone sulfate448.4SRD5A1, SULT2A1, CYP19A1, IGFBP3, IGFBP1, CYP21A2
39vitamin d448.2CRH, SRD5A1, SULT2A1, CYP19A1, IGF1, IGFBP1
40clomiphene citrate448.2GNRH1, CRH, CGA, PRL, FSHB, INS
41gnrh448.0IGFBP1, SHBG, GHRL, CGA, GNRH1, SRD5A1
42thyroxine44 248.8IGFBP1, SHBG, PRL, GHRL, CGA, CRH
43acth447.8SULT2A1, FSHB, LEP, CYP21A2, TRH, IGF1
44estradiol44 11 249.7PRL, CGA, GNRH1, AMH, SRD5A1, SULT2A1
45dhea447.6IGF1, IGFBP3, IGFBP1, SHBG, PRL, GHRL
46androstenedione44 248.6CGA, CRH, GNRH1, PRL, SHBG, IGFBP1
47arginine447.5LEP, CRH, GNRH1, CGA, GHRL, INS
48steroid447.2LEP, CYP21A2, CYP19A1, IGF1, IGFBP3, IGFBP1
49progesterone44 59 28 11 2410.2SRD5A1, SULT2A1, FSHB, FSHR, LEP, CYP21A2
50testosterone44 59 11 248.9IGFBP1, SHBG, PRL, GHRL, CGA, CRH

GO Terms for genes affiliated with Anovulation

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16Gene Ontology
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Cellular components related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.0INS, GHRL
2insulin-like growth factor binding protein complexGO:0169429.7IGF1, IGFBP3
3extracellular spaceGO:0056157.8AMH, GNRH1, BMP15, CRH, GHRL, IGFBP1
4extracellular regionGO:0055766.9FSHB, AMH, GNRH1, CRH, CGA, GHRL

Biological processes related to Anovulation according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1bone mineralization involved in bone maturationGO:03563010.2LEP, IGF1
2ovulation cycleGO:04269810.2GNRH1, PRL
3prostate gland growthGO:06073610.2CYP19A1, IGF1
4follicle-stimulating hormone signaling pathwayGO:04269910.2FSHR, FSHB
5positive regulation of cortisol secretionGO:05146410.2GHRL, CRH
6negative regulation of circadian sleep/wake cycle, REM sleepGO:04232210.2CRH, GHRL
7positive regulation of insulin receptor signaling pathwayGO:04662810.2INS, LEP
8positive regulation of corticotropin secretionGO:05146110.1GHRL, CRH
9negative regulation of glucagon secretionGO:07009310.1LEP, CRH
10glucocorticoid biosynthetic processGO:00670410.1CYP21A2, CRH
11adult feeding behaviorGO:00834310.0LEP, GHRL
12female gamete generationGO:00729210.0BMP15, FSHR, FSHB
13parturitionGO:00756710.0PRL, CRH
14positive regulation of glycogen biosynthetic processGO:04572510.0IGF1, INS
15sex determinationGO:0075309.9AMH, SRD5A1
16positive regulation of glycolysisGO:0458219.9IGF1, INS
17positive regulation of MAPK cascadeGO:0434109.8IGF1, IGFBP3, INS, LEP
18positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.7IGF1, IGFBP3
19steroid metabolic processGO:0082029.7SULT2A1, CYP19A1, CYP21A2, SRD5A1
20response to ethanolGO:0454719.6GNRH1, CRH, PRL, TRH
21female pregnancyGO:0075659.6GNRH1, LEP, PRL, CRH, FSHB
22cell-cell signalingGO:0072679.4INS, TRH, GNRH1, CGA, AMH
23cellular protein metabolic processGO:0442679.2IGF1, FSHB, CGA, IGFBP3, INS, GHRL
24positive regulation of cell proliferationGO:0082849.2FSHB, CRH, CGA, IGF1, LEP, INS
25signal transductionGO:0071658.9CRH, GNRH1, IGFBP1, IGF1, TRH, FSHB

Molecular functions related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.0IGF1, INS
2growth factor activityGO:0080839.1IGF1, BMP15, LEP, AMH
3hormone activityGO:0051798.1CGA, GNRH1, CRH, PRL, IGF1, INS

Products for genes affiliated with Anovulation

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  • Antibodies
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Sources for Anovulation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet