MCID: ANV001
MIFTS: 51

Anovulation malady

Summaries for Anovulation

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63Wikipedia, 32MalaCards
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Wikipedia:63 An anovulatory cycle is a menstrual cycle during which the ovaries do not release an oocyte. Therefore,... more...

MalaCards: Anovulation is related to polycystic ovary syndrome and infertility. An important gene associated with Anovulation is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are Development Prolactin receptor signaling and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and breast, and related mouse phenotypes are adipose tissue and integument.

Aliases & Classifications for Anovulation

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

anovulation 8 10 44 60


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Disease Ontology8 DOID:3781
NCIt39 C34388
SNOMED-CT56 34571000
MeSH34 D000858

Related Diseases for Anovulation

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17GeneCards, 18GeneDecks
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Diseases related to Anovulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome30.8SRD5A1, FSHR, LEP, INS, CYP21A2, CYP19A1
2infertility30.7SULT2A1, FSHB, FSHR, LEP, INS, CYP21A2
3hyperandrogenism30.7SRD5A1, SULT2A1, FSHR, LEP, INS, CYP21A2
4amenorrhea30.5SULT2A1, FSHR, LEP, INS, TRH, IGF1
5obesity30.3SRD5A1, FSHR, LEP, INS, CYP21A2, TRH
6endometriosis30.2FSHR, CYP19A1, IGFBP1, CGA, GNRH1
7ovarian disease30.2FSHR, CYP19A1, IGFBP1, SHBG, PRL, CGA
8breast cancer30.2SRD5A1, CYP19A1, IGFBP3, SHBG, GHRL, GNRH1
9hyperprolactinemia30.2SRD5A1, TRH, IGF1, SHBG, PRL, CGA
10down syndrome30.1CGA
11diabetes mellitus30.0LEP, INS, IGF1, IGFBP3, IGFBP1, SHBG
12systemic lupus erythematosus29.8PRL
13diabetes insipidus29.8TRH, PRL
14ovarian cyst29.8CYP19A1, CGA, GNRH1
15endometrial carcinoma29.8CYP19A1, IGFBP1, GNRH1
16ovarian cancer29.8FSHR, CYP19A1, IGFBP3, GNRH1
17hypothyroidism29.8FSHR, TRH, SHBG, CGA
18glucose intolerance29.8LEP, INS, IGF1, IGFBP3, IGFBP1, SHBG
19hyperinsulinism29.8LEP, INS, CYP21A2, IGF1, IGFBP3, IGFBP1
20pituitary adenoma29.8FSHB, FSHR, LEP, TRH, IGF1, PRL
21adenoma29.8SRD5A1, SULT2A1, FSHB, FSHR, INS, CYP21A2
22vaginitis10.2
23mccune albright syndrome10.0GNRH1
24prostatic hypertrophy10.0GNRH1
25acne10.0SHBG
26alopecia10.0SHBG
27uterine fibroid10.0GNRH1
28prostatitis10.0SRD5A1
29hepatitis10.0IGFBP1
30acute myocardial infarction10.0IGFBP1
31blindness10.0INS
32leukemia10.0IGFBP1
33borderline personality disorder10.0CGA
34aromatase deficiency10.0CYP19A1
35placental insufficiency10.0IGFBP1
36pancreatitis10.0INS
37hypoactive sexual desire disorder10.0SHBG
38hypogonadotropism10.0PRL, GNRH1
39lung cancer10.0IGF1
40hermaphroditism10.0AMH
41ileus10.0GHRL
42cystic fibrosis10.0INS
43testicular cancer10.0SHBG, CGA
44congenital hypothyroidism10.0CYP21A2
45leiomyoma10.0CYP19A1, GNRH1
46conduct disorder10.0CGA
47germinoma10.0CYP21A2, CGA
48myeloma10.0IGF1
49goiter10.0TRH
50acquired generalized lipodystrophy10.0LEP

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to anovulation

Clinical Features for Anovulation

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Drugs & Therapeutics for Anovulation

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Anovulation

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Anatomical Context for Anovulation

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32MalaCards
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MalaCards organs/tissues related to Anovulation:

32
Ovary, Pituitary, Breast, Testes, Brain

Animal Models for Anovulation or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anovulation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.0IGFBP3, CYP19A1, FSHR
2MP:00107719.5GNRH1, CRH, INS, FSHR
3MP:00053799.2SRD5A1, FSHB, FSHR, BMP15, AMH
4MP:00053709.1GNRH1, PRL, IGFBP1, IGFBP3, CYP19A1, INS
5MP:00020068.8AMH, GNRH1, PRL, IGF1, LEP, FSHR
6MP:00053898.6AMH, GNRH1, BMP15, CGA, PRL, FSHR
7MP:00053878.4CRH, PRL, IGFBP1, IGF1, CYP19A1, INS
8MP:00036317.9GNRH1, CRH, CGA, PRL, IGF1, TRH
9MP:00053787.8IGFBP3, CGA, CRH, GNRH1, IGF1, TRH
10MP:00053767.1PRL, GHRL, CGA, CRH, GNRH1, AMH

Publications for Anovulation

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50PubMed
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Articles related to Anovulation:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Pregnancy complications and metabolic disease in women with clomiphene citrate-resistant anovulation randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotropins: a 10-year follow-up. (24268702)
2014
2
Efficacy of different gonadotropin combinations to support ovulation induction in WHO type I anovulation infertility: clinical evidences of human recombinant FSH/human recombinant LH in a 2:1 ratio and highly purified human menopausal gonadotropin stimulation protocols. (23095369)
2012
3
Clomifene citrate or low-dose FSH for the first-line treatment of infertile women with anovulation associated with polycystic ovary syndrome: a prospective randomized multinational study. (22128296)
2012
4
Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares. (21571458)
2011
5
The subcutaneous abdominal fat and not the intraabdominal fat compartment is associated with anovulation in women with obesity and infertility. (20200335)
2010
6
Genetic parameters for anovulation and pregnancy loss in dairy cattle. (19841234)
2009
7
Detection of anovulation by heatmount detectors and transrectal ultrasonography before treatment with progesterone in a timed insemination protocol. (18565948)
2008
8
Ovarian interstitial YAG-laser: an effective new method to manage anovulation in women with polycystic ovary syndrome. (16890553)
2006
9
Effect of anovulation factors on pre- and postmenopausal ovarian cancer risk: revisiting the incessant ovulation hypothesis. (15692075)
2005
10
Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype. (15713728)
2005
11
Metformin versus sibutramine in the treatment of hyperinsulinemia in chronically anovulating women. (15535111)
2004
12
Reproductive adaptations to a large-brained fetus open a vulnerability to anovulation similar to polycystic ovary syndrome. (12704707)
2003
13
Influence of exogenous gonadotropin-releasing hormone on ovarian function in beef cows after short- and long-term nutritionally induced anovulation. (12542168)
2002
14
The administration of cortisone to female B6A mice during their immune adaptive period causes anovulation and the formation of ovarian cysts. (12443030)
2002
15
Comparison of the effectiveness of recombinant and urinary FSH preparations in the achievement of follicular selection in chronic anovulation. (12513854)
2001
16
Anovulation in non-reproductive female Damaraland mole-rats (Cryptomys damarensis). (10864811)
2000
17
New hyperprolactinemia and anovulation model in common marmoset (Callithrix jacchus) and effect of cabergoline. (10096770)
1999
18
Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure. (10342846)
1999
19
Nutritionally induced anovulation in beef heifers: ovarian and endocrine function preceding cessation of ovulation. (10375231)
1999
20
On the mechanism of lactational anovulation in the rhesus monkey. (9575828)
1998
21
Ovulation induction with pulsatile GnRH in a patient with anovulation of hypothalamic origin and central diabetes insipidus. (9675568)
1998
22
Estimated prevalence of undiagnosed glucose intolerance from hyperandrogenic anovulation among women requesting electrolysis. (9309459)
1997
23
Ad libitum suckling by an unrelated calf in the presence or absence of a cow's own calf prolongs postpartum anovulation. (9331882)
1997
24
Anovulation and monophasic cycles. (9238267)
1997
25
The effect of alprazolam on serum cortisol and luteinizing hormone pulsatility in normal women and in women with stress-related anovulation. (7883836)
1995
26
Sensory and behavioural control of gonadotrophin secretion during suckling-mediated anovulation in cows. (7623335)
1995
27
Evidence for maternal behavior as a requisite link in suckling-mediated anovulation in cows. (8286616)
1993
28
Enhanced ovarian inhibin subunit gene expression in aging rats is due to chronic anovulation. (8286603)
1993
29
Prolonged postpartum anovulation in mastectomized cows requires tactile stimulation by the calf. (8478299)
1993
30
Gonadotropin releasing hormone loading test with bromocryptin therapy: a new possibility in the differential diagnosis of normo-prolactinaemic anovulation]. (1625857)
1992
31
Lactational [correction of Lacational] anovulation in rats and its dependency on progesterone. (1984246)
1991
32
The mechanism of the effect of combination treatment with clomiphene and bromocriptine in patients with normoprolactinemic anovulation. (2121818)
1990
33
Incidence of anovulation in cyclic menstruating infertile women. (12315540)
1987
34
Use of LHRH agonists in the treatment of anovulation in women with polycystic ovary syndrome. (3136067)
1987
35
Effects of intermittent injections of LHRH on secretory patterns of LH and FSH and ovarian follicular growth during postpartum anovulation in suckled beef cows. (3087926)
1986
36
Anovulation in postpartum suckled beef cows. I. Associations among size and numbers of ovarian follicles, uterine involution, and hormones in serum and follicular fluid. (3700270)
1986
37
Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase. (6423124)
1984
38
Anovulation presumably due to the gonadotrophin-resistant ovary syndrome. (6705963)
1984
39
Nature of the light stimulus producing Aschoff's intensity effect and anovulation. (6465345)
1984
40
Chronic anovulation. (6241119)
1984
41
Prevention of continuous light-induced anovulation in rats by early exposure to continuous light. (6640025)
1983
42
Combined medical and surgical treatment for transverse vaginal septum associated with anovulation. (7075804)
1982
43
Estrogen provocation test: lack of correlation between LH and 17-beta-estradiol basal levels and LH peak response in hypothalamic chronic anovulation. (6764580)
1982
44
Treatment of chronic anovulation and corpus luteum deficiency with epimestrol. (7250485)
1981
45
Anovulation: etiology, investigation and treatment. (271235)
1978
46
Anovulation in adult female rats after neonatal intracerebral implantation of oestrogen. (1222740)
1975
47
Induction of ovulation with synthetic gonadotrophin-releasing hormone in women with constant anovulation induced by contraceptive steroids. (4132247)
1974
48
Clinical results with human gonadotrophins in anovulation, using two alternative dosage schemes. (5014975)
1972
49
Treatment of infertility due to anovulation. (5195464)
1969
50
Treatment of anovulation with menotropins. (5694897)
1968

Genetic Variations for Anovulation

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Expression for genes affiliated with Anovulation

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anovulation

Search GEO for disease gene expression data for Anovulation.

Pathways for genes affiliated with Anovulation

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN
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Pathways related to Anovulation according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Prolactin receptor signaling
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10.0PRL, INS
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.8CGA, IGF1, CYP19A1
39.8IGF1, IGFBP3, IGFBP1
49.8IGFBP1, IGFBP3, IGF1
59.8LEP, INS, PRL
6
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9.7SRD5A1, CYP21A2, CYP19A1
7
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9.6GNRH1, CGA, FSHR, FSHB
89.6CGA, CYP19A1, FSHR, FSHB
9
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9.5CGA, GHRL, INS, FSHB
10
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9.4FSHB, FSHR, CGA, CRH
11
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9.3INS, IGF1, PRL, BMP15, GNRH1
129.3FSHB, LEP, INS, IGFBP1, CGA
13
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8.9CGA, GHRL, IGFBP1, IGFBP3, IGF1, INS
148.8FSHB, BMP15, CGA, IGF1, CYP19A1, INS
15
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8.2GNRH1, CRH, CGA, GHRL, PRL, TRH
16
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7.9GNRH1, CRH, CGA, GHRL, PRL, IGF1

Compounds for genes affiliated with Anovulation

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Anovulation according to GeneCards/GeneDecks:

(show top 50)    (show all 214)
idCompoundScoreTop Affiliating Genes
1estrogen4410.0TRH, SRD5A1
2goserelin44 28 1111.8SRD5A1, GNRH1, CGA
3norepinephrine44 11 2411.8CYP21A2, TRH, PRL, CGA, GNRH1
4oxandrolone44 1110.6SHBG, IGFBP3, IGF1, GHRL, INS
511 deoxycortisol449.5CGA, CRH, SHBG, CYP21A2, PRL
6leuprolide44 59 28 1112.5IGF1, PRL, CGA, GNRH1, SRD5A1
7letrozole44 49 59 1112.5IGFBP3, LEP, CYP19A1, SHBG, IGF1, CGA
8bromocriptine28 44 1111.4SHBG, CGA, PRL, IGFBP3, TRH, GNRH1
9flutamide44 59 1111.4CGA, SRD5A1, CYP19A1, SHBG, PRL, GNRH1
10levonorgestrel44 59 28 1112.3SHBG, PRL, IGFBP1, IGFBP3, SRD5A1, CYP19A1
11ghrp449.3IGF1, PRL, IGFBP3, GHRL, TRH
12cyproteroneacetate449.3SRD5A1, INS, CYP19A1, SHBG, PRL, GHRL
13leuprolide acetate449.3CGA, GNRH1, PRL, SHBG, IGF1, FSHB
14megestrol acetate449.3SHBG, IGFBP3, IGF1, CYP19A1, LEP
15hexarelin44 2810.2IGF1, PRL, GHRL, CRH, IGFBP3
16anastrozole44 1110.2IGFBP3, SHBG, CGA, CYP19A1, IGFBP1
17buserelin44 28 1111.2FSHB, CYP19A1, IGF1, IGFBP3, IGFBP1, PRL
18progestins449.1SHBG, IGFBP1, IGFBP3, CYP19A1, SRD5A1, GNRH1
19c-peptide449.1GHRL, SHBG, CYP21A2, IGFBP1, INS, IGFBP3
20cortisone44 2410.0INS, LEP, SRD5A1, CYP21A2, IGF1, CRH
21metformin44 49 1111.0IGF1, IGFBP1, SHBG, GHRL, CGA, GNRH1
22pyridostigmine44 1110.0TRH, IGF1, IGFBP3, IGFBP1, PRL, GHRL
23mifepristone44 59 28 1112.0AMH, CYP19A1, IGFBP1, CRH, SHBG, PRL
24naloxone44 49 28 1112.0CRH, GNRH1, TRH, GHRL, CGA, PRL
25progestin448.9SRD5A1, CYP19A1, IGF1, IGFBP3, IGFBP1, SHBG
2617-hydroxyprogesterone44 249.8PRL, CGA, CRH, GNRH1, SHBG, IGFBP1
27dopamine44 28 11 2411.7SRD5A1, IGF1, SHBG, GHRL, GNRH1, TRH
28dexamethasone44 49 28 1111.7GNRH1, SULT2A1, INS, CYP21A2, TRH, SHBG
29epinephrine44 11 2410.7CRH, CGA, GHRL, LEP, INS, CYP21A2
30octreotide44 59 28 1111.6INS, TRH, IGF1, IGFBP3, IGFBP1, PRL
31triiodothyronine448.5PRL, GHRL, CGA, SHBG, IGFBP1, IGFBP3
32estrone44 28 11 2411.5SHBG, PRL, GNRH1, IGFBP1, IGFBP3, IGF1
33dihydrotestosterone44 28 11 2411.4IGFBP3, CYP19A1, IGF1, SRD5A1, LEP, CYP21A2
34creatinine448.4IGFBP3, IGF1, INS, LEP, IGFBP1, CRH
35ribonucleic acid448.4FSHB, FSHR, CYP21A2, IGF1, IGFBP3, IGFBP1
36tamoxifen44 49 28 1111.4GNRH1, AMH, SULT2A1, LEP, CYP19A1, IGF1
37hydrocortisone44 2 59 1111.4CRH, GHRL, INS, CYP21A2, CYP19A1, TRH
38dehydroepiandrosterone sulfate448.4SRD5A1, SULT2A1, CYP19A1, IGFBP3, IGFBP1, CYP21A2
39vitamin d448.2CRH, SRD5A1, SULT2A1, CYP19A1, IGF1, IGFBP1
40clomiphene citrate448.2GNRH1, CRH, CGA, PRL, FSHB, INS
41gnrh448.0IGFBP1, SHBG, GHRL, CGA, GNRH1, SRD5A1
42thyroxine44 248.8IGFBP1, SHBG, PRL, GHRL, CGA, CRH
43acth447.8SULT2A1, FSHB, LEP, CYP21A2, TRH, IGF1
44estradiol44 11 249.7PRL, CGA, GNRH1, AMH, SRD5A1, SULT2A1
45dhea447.6IGF1, IGFBP3, IGFBP1, SHBG, PRL, GHRL
46androstenedione44 248.6CGA, CRH, GNRH1, PRL, SHBG, IGFBP1
47arginine447.5LEP, CRH, GNRH1, CGA, GHRL, INS
48steroid447.2LEP, CYP21A2, CYP19A1, IGF1, IGFBP3, IGFBP1
49progesterone44 59 28 11 2410.2SRD5A1, SULT2A1, FSHB, FSHR, LEP, CYP21A2
50testosterone44 59 11 248.9IGFBP1, SHBG, PRL, GHRL, CGA, CRH

GO Terms for genes affiliated with Anovulation

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16Gene Ontology
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Cellular components related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.0INS, GHRL
2insulin-like growth factor binding protein complexGO:0169429.7IGF1, IGFBP3
3extracellular spaceGO:0056157.8AMH, GNRH1, BMP15, CRH, GHRL, IGFBP1
4extracellular regionGO:0055766.9FSHB, AMH, GNRH1, CRH, CGA, GHRL

Biological processes related to Anovulation according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1bone mineralization involved in bone maturationGO:03563010.2LEP, IGF1
2ovulation cycleGO:04269810.2PRL, GNRH1
3prostate gland growthGO:06073610.2IGF1, CYP19A1
4follicle-stimulating hormone signaling pathwayGO:04269910.2FSHB, FSHR
5positive regulation of cortisol secretionGO:05146410.2CRH, GHRL
6negative regulation of circadian sleep/wake cycle, REM sleepGO:04232210.2CRH, GHRL
7positive regulation of insulin receptor signaling pathwayGO:04662810.2INS, LEP
8positive regulation of corticotropin secretionGO:05146110.1GHRL, CRH
9negative regulation of glucagon secretionGO:07009310.1CRH, LEP
10glucocorticoid biosynthetic processGO:00670410.1CYP21A2, CRH
11adult feeding behaviorGO:00834310.0LEP, GHRL
12female gamete generationGO:00729210.0BMP15, FSHR, FSHB
13parturitionGO:00756710.0CRH, PRL
14positive regulation of glycogen biosynthetic processGO:04572510.0INS, IGF1
15sex determinationGO:0075309.9SRD5A1, AMH
16positive regulation of glycolysisGO:0458219.9INS, IGF1
17positive regulation of MAPK cascadeGO:0434109.8LEP, INS, IGF1, IGFBP3
18positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.7IGF1, IGFBP3
19steroid metabolic processGO:0082029.7CYP19A1, CYP21A2, SULT2A1, SRD5A1
20response to ethanolGO:0454719.6GNRH1, CRH, PRL, TRH
21female pregnancyGO:0075659.6FSHB, LEP, PRL, CRH, GNRH1
22cell-cell signalingGO:0072679.4INS, TRH, CGA, GNRH1, AMH
23cellular protein metabolic processGO:0442679.2CGA, GHRL, IGFBP1, IGFBP3, IGF1, INS
24positive regulation of cell proliferationGO:0082849.2FSHB, LEP, INS, IGF1, CGA, CRH
25signal transductionGO:0071658.9GNRH1, CRH, CGA, IGFBP1, IGF1, TRH

Molecular functions related to Anovulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.0INS, IGF1
2growth factor activityGO:0080839.1AMH, BMP15, IGF1, LEP
3hormone activityGO:0051798.1FSHB, AMH, GNRH1, CRH, CGA, PRL

Products for genes affiliated with Anovulation

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  • Antibodies
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Sources for Anovulation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet