MCID: ANV001
MIFTS: 44

Anovulation malady

Categories: Reproductive diseases

Aliases & Classifications for Anovulation

Aliases & Descriptions for Anovulation:

Name: Anovulation 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3781
MeSH 42 D000858
NCIt 47 C34388
SNOMED-CT 64 34571000
UMLS 69 C0003128

Summaries for Anovulation

MalaCards based summary : Anovulation is related to endometriosis and polycystic ovary syndrome. An important gene associated with Anovulation is SHBG (Sex Hormone Binding Globulin), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and Prolactin Signaling Pathway. The drugs Cyproterone Acetate and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and endocrine/exocrine gland

Wikipedia : 71 Anovulation is when the ovaries do not release an oocyte during a menstrual cycle. Therefore, ovulation... more...

Related Diseases for Anovulation

Diseases related to Anovulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
id Related Disease Score Top Affiliating Genes
1 endometriosis 30.1 GNRH1 PRL
2 polycystic ovary syndrome 11.2
3 resistance to lh 10.8
4 hyperandrogenism 10.3
5 african histoplasmosis 10.3 GNRH1 PRL
6 polyneuropathy 10.2 CYP19A1 SHBG
7 diabetes mellitus, insulin-dependent, 2 10.2 INS SHBG
8 diverticulitis 10.2 GNRH1 PRL
9 dystonia-parkinsonism, x-linked 10.2 CYP19A1 SHBG
10 infertility 10.2
11 intraventricular meningioma 10.2 CGA SHBG
12 intermittent squint 10.2 GNRH1 PRL
13 extragonadal nonseminomatous germ cell tumor 10.2 GNRH1 PRL
14 cervical spinal canal and spinal cord meningioma 10.2 CGA CYP19A1
15 periodic fever, aphthous stomatitis, pharyngitis and adenitis 10.2 CGA GNRH1
16 seow najjar syndrome 10.2 IGF1 INS
17 critical congenital heart disease 10.2 GNRH1 IGF1
18 cockayne syndrome type i 10.2 INS PRL
19 astroblastoma 10.2 GNRH1 PRL SHBG
20 trachea carcinoma in situ 10.2 CGA SHBG
21 vertebral artery occlusion 10.2 GNRH1 INS PRL
22 olfactory nerve neoplasm 10.2 GNRH1 INS PRL
23 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.2 CGA GNRH1 SHBG
24 congenital articular rigidity 10.2 CGA CYP19A1 SHBG
25 diarrhea 3, secretory sodium, congenital, syndromic 10.2 IGF1 INS
26 emery-dreifuss muscular dystrophy 3, ar 10.2 INS LEP
27 hypospadias 1, x-linked 10.2 CGA CYP19A1 SHBG
28 diencephalic neoplasm 10.2 GNRH1 INS PRL
29 adrenal cortical adenocarcinoma 10.2 GNRH1 INS PRL
30 leydig cell hypoplasia with pseudohermaphroditism 10.2 CYP19A1 FSHR
31 glioblastoma mesenchymal subtype 10.1 CYP19A1 PRL SHBG
32 leukoencephalopathy with ataxia 10.1 CYP19A1 SHBG
33 adams-oliver syndrome 6 10.1 CYP19A1 GNRH1 INS
34 renal-hepatic-pancreatic dysplasia 10.1 CGA GNRH1 IGF1
35 transient neonatal thrombocytopenia 10.1 PRL SHBG
36 autosomal recessive congenital ichthyosis 10.1 INS LEP
37 dacryoadenitis 10.1 IGF1 INS PRL
38 8p23.1 duplication syndrome 10.1 BMP15 FSHR
39 adult medulloblastoma 10.1 GNRH1 IGF1 SHBG
40 leg dermatosis 10.1 INS LEP SHBG
41 protein s deficiency 10.1 IGF1 INS PRL
42 necrobiosis lipoidica 10.1 IGF1 PRL SHBG
43 intramuscular hemangioma 10.1 BMP15 GNRH1
44 pituitary adenoma, acth-secreting 10.1 IGF1 PRL
45 cervix squamous papilloma 10.1 IGF1 INS PRL
46 vestibular gland benign neoplasm 10.1 IGF1 INS PRL
47 bile acid synthesis defect, congenital, 4 10.1 GNRH1 IGF1 PRL
48 antidepressant type abuse 10.1 INS LEP SHBG
49 thrombophilia 10.1 IGF1 INS PRL
50 amenorrhea 10.1

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to Anovulation

Symptoms & Phenotypes for Anovulation

GenomeRNAi Phenotypes related to Anovulation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.62 IGF1 LEP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.62 LEP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.62 IGF1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.62 IGF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.62 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.62 IGF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.62 SHBG
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.62 IGF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.62 BMP15
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.62 IGF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.62 LEP SHBG BMP15 IGF1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.62 LEP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.62 IGF1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.62 LEP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.62 IGF1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.62 BMP15

MGI Mouse Phenotypes related to Anovulation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.17 CYP19A1 FSHB FSHR GNRH1 IGF1 INS
2 homeostasis/metabolism MP:0005376 10.1 AMHR2 CGA CYP19A1 FSHB FSHR GNRH1
3 immune system MP:0005387 9.97 IGF1 INS LEP PRL AMHR2 CYP19A1
4 integument MP:0010771 9.92 AMHR2 CYP19A1 FSHR GNRH1 IGF1 INS
5 adipose tissue MP:0005375 9.85 CYP19A1 FSHR IGF1 INS LEP
6 nervous system MP:0003631 9.76 PRL CGA CYP19A1 FSHR GNRH1 IGF1
7 neoplasm MP:0002006 9.73 GNRH1 IGF1 LEP PRL AMHR2 FSHR
8 renal/urinary system MP:0005367 9.43 AMHR2 CYP19A1 GNRH1 IGF1 INS LEP
9 reproductive system MP:0005389 9.36 AMHR2 BMP15 CGA CYP19A1 FSHB FSHR

Drugs & Therapeutics for Anovulation

Drugs for Anovulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
2
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
3
Metformin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 657-24-9 14219 4091
4
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 50-28-2 5757 53477783
5
Letrozole Approved, Investigational Phase 4,Phase 2,Early Phase 1 112809-51-5 3902
6
Menotropins Approved Phase 4,Phase 1,Phase 2 61489-71-2 5360545
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
8
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3 71-58-9
9
Drospirenone Approved Phase 4 67392-87-4 68873
10
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
12
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
13
Enclomiphene Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 15690-57-0
14 Androgen Antagonists Phase 4,Phase 2
15 Androgens Phase 4,Phase 2,Early Phase 1
16 Contraceptive Agents Phase 4,Phase 3
17 Contraceptive Agents, Male Phase 4,Phase 3
18 Contraceptives, Oral Phase 4,Phase 3
19
Cyproterone Phase 4 2098-66-0 5284537
20 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
24 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Chelating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Clomiphene Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Fertility Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Selective Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Zuclomiphene Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Tin Fluorides Phase 4,Phase 3
35 Estradiol 17 beta-cypionate Phase 4,Phase 3,Early Phase 1
36 Estradiol 3-benzoate Phase 4,Phase 3,Early Phase 1
37 Estradiol valerate Phase 4,Phase 3,Early Phase 1 979-32-8
38 Polyestradiol phosphate Phase 4,Phase 3,Early Phase 1
39 insulin Phase 4,Phase 3,Phase 2,Early Phase 1
40 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Early Phase 1
41 Aromatase Inhibitors Phase 4,Phase 2,Early Phase 1
42 Steroid Synthesis Inhibitors Phase 4,Phase 2,Early Phase 1
43 Contraceptives, Oral, Combined Phase 4
44 Follicle Stimulating Hormone Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Hematinics Phase 4
46 Micronutrients Phase 4
47 Trace Elements Phase 4
48 Vitamin B Complex Phase 4
49 Vitamins Phase 4
50 Pharmaceutical Solutions Phase 4,Phase 1

Interventional clinical trials:

(show top 50) (show all 107)
id Name Status NCT ID Phase
1 PCOS, Therapy and Markers of Cardiovascular Risk Unknown status NCT01798875 Phase 4
2 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4
3 Study of Mechanisms of Anovulation in Polycystic Ovary Syndrome Completed NCT00492882 Phase 4
4 Treatment of Anovulatory Infertility in PCOS Patients Completed NCT00471523 Phase 4
5 Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility Completed NCT01250821 Phase 4
6 Short-term Structured Exercise Training Program Plus Diet Intervention in Patients With Polycystic Ovary Syndrome (PCOS) Completed NCT01004068 Phase 4
7 Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients Completed NCT00953355 Phase 4
8 Efficacy Study of the OV-Watch™ Personal Fertility Monitor for Women Using Clomiphene Citrate. Completed NCT00239603 Phase 4
9 Second-Line Treatments for Anovulatory Infertility in PCOS Patients Completed NCT00558077 Phase 4
10 Structured Exercise Training Program Versus Hypocaloric Hyperproteic Diet in Obese Anovulatory Infertile Patients With PCOS Completed NCT00473538 Phase 4
11 Recombinant Follicle Stimulating Hormone (FSH) (Gonal-f®): Use in Ovulation Induction Completed NCT01081626 Phase 4
12 Endometrial Shedding Prior to Ovulation Induction Pilot Study Completed NCT02340013 Phase 4
13 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed NCT01360996 Phase 4
14 N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome Completed NCT02239107 Phase 4
15 Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos. Completed NCT01896492 Phase 4
16 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4
17 Letrozole Versus Clomifene Citrate for Ovulation Induction Completed NCT00478504 Phase 4
18 PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene Completed NCT00795808 Phase 4
19 Administration of Single High Dose Letrozole for Ovulation Induction Recruiting NCT02703649 Phase 4
20 Concomitant CC and E2 Versus CC Alone in Ovulation Induction Recruiting NCT02186782 Phase 4
21 Metformin in Infertile PCOS Patients Recruiting NCT00501904 Phase 4
22 The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS Active, not recruiting NCT02866786 Phase 4
23 Pilot Study:Role of Dietary Fiber in PCOS Anovulation Terminated NCT00703092 Phase 4
24 Low-dose Gonal-f® in Ovulation Induction Terminated NCT01871532 Phase 4
25 Metformin in Assisted Reproduction-MET-AR-study Terminated NCT00159575 Phase 4
26 Metformin Administration in Infertile Anovulatory PCOS Patients Withdrawn NCT00501787 Phase 4
27 Clomiphene Citrate in Infertile PCOS Patients Withdrawn NCT00501839 Phase 4
28 Phase III Clinical Study of Domestic Recombinant Human Follitropin for Injection to Treat WHO Class II Anovulation Completed NCT02335879 Phase 3
29 A Phase III Clinical Study to Compare the Efficacy and Safety of DA-3801 and That of Gonal-F® Completed NCT01820728 Phase 3
30 Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women Completed NCT01653743 Phase 3
31 Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females Completed NCT01923194 Phase 3
32 Traditional Clomiphene Citrate Administration vs. Stair-step Approach Completed NCT01008319 Phase 3
33 Ovarian Laser Treatment in Women With Polycystic Ovarian Syndrome: A Randomized Study on the Laser Dose Completed NCT00643708 Phase 3
34 The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women Completed NCT00413179 Phase 3
35 Thermosensitive Gels for the Vaginal Delivery of Sildenafil Citrate Completed NCT02766725 Phase 2, Phase 3
36 Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS Completed NCT01482286 Phase 3
37 Efficacy of Cyclic DSG Compared With Cyclic MPA for the Treatment of Anovulatory DUB Recruiting NCT02103764 Phase 3
38 Comparison of Anastrozole Verses Clomiphene Citrate in Stimulating Follicular Growth and Ovulation in Infertile Women With Ovulatory Dysfunction Completed NCT00213148 Phase 2
39 Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome Completed NCT00947713 Phase 1, Phase 2
40 Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome Patients Completed NCT02562664 Phase 2
41 Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS) Completed NCT00151411 Phase 2
42 Clomiphene Citrate Plus Cabergoline in Treatment of Polycystic Ovary Syndrome Recruiting NCT02644304 Phase 2
43 Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women Recruiting NCT01889199 Phase 2
44 Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS ) Not yet recruiting NCT02551367 Phase 2
45 AS900672-Enriched in Ovulation Induction Terminated NCT00553514 Phase 2
46 Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene Completed NCT01289756 Phase 1
47 Bioequivalence Trial of Liquid Versus Freeze-Dried Pergoveris® in Pituitary Suppressed Healthy Premenopausal Female Subjects Completed NCT02317809 Phase 1
48 Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome Unknown status NCT00665171
49 The Role of Insulin Resistance in PCOS Unknown status NCT00173043
50 Long Acting GnRH Antagonist in PCOS Women Undergoing IVF Unknown status NCT02084940

Search NIH Clinical Center for Anovulation

Cochrane evidence based reviews: anovulation

Genetic Tests for Anovulation

Anatomical Context for Anovulation

MalaCards organs/tissues related to Anovulation:

39
Ovary, Pituitary, Testes, Breast, Bone, Brain

Publications for Anovulation

Articles related to Anovulation:

(show top 50) (show all 318)
id Title Authors Year
1
Low-dose aspirin and sporadic anovulation in the EAGeR randomized trial. ( 27754808 )
2016
2
Subfertility in rheumatoid arthritis is often unexplained or caused by anovulation. ( 27723275 )
2016
3
Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study. ( 27225433 )
2016
4
Dairy Food Intake Is Associated with Reproductive Hormones and Sporadic Anovulation among Healthy Premenopausal Women. ( 27881593 )
2016
5
Metformin for women with hyperandrogenic anovulation. ( 26906093 )
2016
6
Reply: Metformin for women with hyperandrogenic anovulation. ( 26906091 )
2016
7
Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries. ( 26040673 )
2015
8
Factors associated with nonresponse to ovulation induction using letrozole among women with World Health Organization group II anovulation. ( 26157297 )
2015
9
Non-reproductive Effects of Anovulation: Bone Metabolism in the Luteal Phase of Premenopausal Women Differs between Ovulatory and Anovulatory Cycles. ( 26726266 )
2015
10
Role of cortisol and superoxide dismutase in psychological stress induced anovulation. ( 26393311 )
2015
11
Prevalence of conditions causing chronic anovulation and the proposed algorithm for anovulation evaluation. ( 25772812 )
2015
12
Loss of Body Fat and Associated Decrease in Leptin in Early Lactation Are Related to Shorter Duration of Postpartum Anovulation in Healthy US Women. ( 25596410 )
2015
13
Serum zonulin is elevated in women with polycystic ovary syndrome, and correlates with insulin resistance and severity of anovulation. ( 25336505 )
2014
14
Cost-effectiveness analysis on the use of rFSH + rLH for the treatment of anovulation in hypogonadotropic hypogonadal women. ( 25028553 )
2014
15
Individual and combined effects of anovulation and cytological endometritis on the reproductive performance of dairy cows. ( 24996269 )
2014
16
Willingness to pay for ovulation induction treatment in case of WHO II anovulation: a study using the contingent valuation method. ( 25328385 )
2014
17
Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. ( 24169550 )
2014
18
Visceral adiposity index (VAI) is related to the severity of anovulation and other clinical features in women with polycystic ovary syndrome. ( 24601936 )
2014
19
Terms and thresholds for the ultrasound evaluation of the ovaries in women with hyperandrogenic anovulation. ( 24516084 )
2014
20
The role of AMH in anovulation associated with PCOS: a hypothesis. ( 24770999 )
2014
21
Assessment of anovulation in eumenorrheic women: comparison of ovulation detection algorithms. ( 24875398 )
2014
22
Accounting for Anovulation and Vaginal Thinning During Depot Medroxyprogesterone Acetate Use. ( 25217405 )
2014
23
Examining the ovaries by ultrasound for diagnosing hyperandrogenic anovulation: updating the threshold for newer machines. ( 24534278 )
2014
24
Counting ovarian follicles: updated threshold for diagnosis of hyperandrogenic anovulation. ( 25088509 )
2014
25
Pregnancy complications and metabolic disease in women with clomiphene citrate-resistant anovulation randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotropins: a 10-year follow-up. ( 24268702 )
2014
26
Depressive symptoms and their relationship with endogenous reproductive hormones and sporadic anovulation in premenopausal women. ( 25453349 )
2014
27
Increased androgen, anti-MA1llerian hormone, and sporadic anovulation in healthy, eumenorrheic women: a mild PCOS-like phenotype? ( 24606085 )
2014
28
British Fertility Society. 'Ovulation induction in WHO Type 1 anovulation: Guidelines for practice'. Produced on behalf of the BFS Policy and Practice Committee. ( 24245485 )
2013
29
The M-OVIN study: does switching treatment to FSH and / or IUI lead to higher pregnancy rates in a subset of women with world health organization type II anovulation not conceiving after six ovulatory cycles with clomiphene citrate - a randomised controlled trial. ( 24160333 )
2013
30
The influence of sporadic anovulation on hormone levels in ovulatory cycles. ( 23589536 )
2013
31
Loss of LH-induced down-regulation of anti-MA1llerian hormone receptor expression may contribute to anovulation in women with polycystic ovary syndrome. ( 23321213 )
2013
32
Clinical review: Adolescent anovulation: maturational mechanisms and implications. ( 23913942 )
2013
33
Risk factors and effects of postpartum anovulation in dairy cows. ( 22459832 )
2012
34
Cornual polyps of the fallopian tube are associated with endometriosis and anovulation. ( 22190955 )
2012
35
Clomifene citrate or low-dose FSH for the first-line treatment of infertile women with anovulation associated with polycystic ovary syndrome: a prospective randomized multinational study. ( 22128296 )
2012
36
Chinese herbal medicine for infertility with anovulation: a systematic review. ( 23198826 )
2012
37
Progestogens with or without oestrogen for irregular uterine bleeding associated with anovulation. ( 22972055 )
2012
38
Balancing ovulation and anovulation: integration of the reproductive and energy balance axes by neuropeptides. ( 22442260 )
2012
39
Efficacy of different gonadotropin combinations to support ovulation induction in WHO type I anovulation infertility: clinical evidences of human recombinant FSH/human recombinant LH in a 2:1 ratio and highly purified human menopausal gonadotropin stimulation protocols. ( 23095369 )
2012
40
Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares. ( 21571458 )
2011
41
Chinese herbal medicine and clomiphene citrate for anovulation: a meta-analysis of randomized controlled trials. ( 21563919 )
2011
42
Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women. ( 21543284 )
2011
43
Female infertility due to anovulation and defective steroidogenesis in NPC2 deficient mice. ( 19883728 )
2010
44
Anovulation with or without PCO, hyperandrogenaemia and hyperinsulinaemia as promoters of endometrial and breast cancer. ( 19264556 )
2010
45
The subcutaneous abdominal fat and not the intraabdominal fat compartment is associated with anovulation in women with obesity and infertility. ( 20200335 )
2010
46
Aberrant follicle development and anovulation in polycystic ovary syndrome. ( 20362969 )
2010
47
Genetic parameters for anovulation and pregnancy loss in dairy cattle. ( 19841234 )
2009
48
Oligo-ovulation or anovulation and hyperandrogenemia contribute to the decreased serum adiponectin levels in normal-weight women with PCOS with obesity and insulin resistance. ( 19243758 )
2009
49
Body shape and size and insulin resistance as early clinical predictors of hyperandrogenic anovulation in ethnic minority adolescent girls. ( 18639784 )
2008
50
Detection of anovulation by heatmount detectors and transrectal ultrasonography before treatment with progesterone in a timed insemination protocol. ( 18565948 )
2008

Variations for Anovulation

Expression for Anovulation

Search GEO for disease gene expression data for Anovulation.

Pathways for Anovulation

Pathways related to Anovulation according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 CGA FSHB GNRH1 IGF1
2
Show member pathways
12.16 CGA INS LEP PRL
3
Show member pathways
11.91 CGA FSHB IGF1 INS LEP
4 11.84 CGA FSHB FSHR
5 11.75 IGF1 INS LEP
6 11.59 IGF1 INS LEP
7 11.24 INS LEP PRL
8 11.15 CGA CYP19A1 IGF1
9 11.04 CYP19A1 FSHR
10 10.89 CGA CYP19A1 FSHB FSHR
11 10.87 FSHB FSHR
12 10.87 BMP15 CGA CYP19A1 FSHB FSHR IGF1
13 10.73 GNRH1 SHBG
14 10.37 CGA FSHB FSHR GNRH1

GO Terms for Anovulation

Cellular components related to Anovulation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 BMP15 FSHB GNRH1 IGF1 INS LEP
2 extracellular region GO:0005576 9.28 BMP15 CGA FSHB GNRH1 IGF1 INS
3 endosome lumen GO:0031904 8.96 INS PRL

Biological processes related to Anovulation according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.83 CGA FSHB GNRH1 INS
2 cellular protein metabolic process GO:0044267 9.78 BMP15 IGF1 INS PRL
3 response to ethanol GO:0045471 9.76 GNRH1 LEP PRL
4 positive regulation of MAPK cascade GO:0043410 9.67 IGF1 INS LEP
5 positive regulation of cell migration GO:0030335 9.67 CGA FSHB IGF1 INS
6 positive regulation of glucose import GO:0046326 9.64 IGF1 INS
7 hormone-mediated signaling pathway GO:0009755 9.63 FSHB FSHR
8 regulation of multicellular organism growth GO:0040014 9.63 IGF1 PRL
9 activation of protein kinase B activity GO:0032148 9.62 IGF1 INS
10 positive regulation of mitotic nuclear division GO:0045840 9.62 IGF1 INS
11 peptide hormone processing GO:0016486 9.61 CGA FSHB
12 positive regulation of JAK-STAT cascade GO:0046427 9.61 LEP PRL
13 uterus development GO:0060065 9.6 CYP19A1 FSHR
14 regulation of osteoclast differentiation GO:0045670 9.59 FSHB FSHR
15 positive regulation of glycogen biosynthetic process GO:0045725 9.58 IGF1 INS
16 positive regulation of glycolytic process GO:0045821 9.57 IGF1 INS
17 positive regulation of insulin receptor signaling pathway GO:0046628 9.55 INS LEP
18 gonad development GO:0008406 9.54 CGA FSHR
19 ovulation cycle GO:0042698 9.51 GNRH1 PRL
20 female gonad development GO:0008585 9.5 AMHR2 CYP19A1 FSHR
21 Sertoli cell proliferation GO:0060011 9.46 FSHB FSHR
22 female pregnancy GO:0007565 9.46 FSHB GNRH1 LEP PRL
23 bone mineralization involved in bone maturation GO:0035630 9.43 IGF1 LEP
24 female gamete generation GO:0007292 9.43 BMP15 FSHB FSHR
25 positive regulation of cell proliferation GO:0008284 9.43 CGA FSHB IGF1 INS LEP PRL
26 follicle-stimulating hormone signaling pathway GO:0042699 9.4 FSHB FSHR
27 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.92 FSHR IGF1 INS LEP
28 signal transduction GO:0007165 10.1 AMHR2 CGA FSHB FSHR GNRH1 IGF1

Molecular functions related to Anovulation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 BMP15 IGF1 LEP
2 insulin receptor binding GO:0005158 9.26 IGF1 INS
3 hormone activity GO:0005179 9.17 CGA FSHB GNRH1 IGF1 INS LEP
4 insulin-like growth factor receptor binding GO:0005159 8.96 IGF1 INS

Sources for Anovulation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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