MCID: ANV001
MIFTS: 48

Anovulation

Categories: Reproductive diseases

Aliases & Classifications for Anovulation

MalaCards integrated aliases for Anovulation:

Name: Anovulation 12 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3781
MeSH 41 D000858
NCIt 46 C34388
SNOMED-CT 64 34571000
UMLS 69 C0003128

Summaries for Anovulation

MalaCards based summary : Anovulation is related to hypogonadotropism and hyperprolactinemia. An important gene associated with Anovulation is SHBG (Sex Hormone Binding Globulin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Development Endothelin-1/EDNRA signaling. The drugs Metformin and Cyproterone Acetate have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 72 Anovulation is when the ovaries do not release an oocyte during a menstrual cycle. Therefore, ovulation... more...

Related Diseases for Anovulation

Diseases related to Anovulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 hypogonadotropism 30.1 GNRH1 PRL
2 hyperprolactinemia 30.0 GNRH1 IGF1 PRL
3 polycystic ovary syndrome 30.0 CYP19A1 FSHR GNRH1 IGF1 INS LEP
4 diabetes insipidus, neurohypophyseal 29.9 GNRH1 PRL
5 premenstrual tension 29.9 GNRH1 PRL SHBG
6 infertility 29.7 CYP19A1 FSHB FSHR GNRH1 PRL
7 oocyte maturation defect 1 29.7 BMP15 CGA CYP19A1
8 body mass index quantitative trait locus 11 29.6 IGF1 INS LEP SHBG
9 hyperandrogenism 29.6 CYP19A1 GNRH1 IGF1 INS PRL SHBG
10 hypothyroidism 29.5 LEP PRL SHBG
11 diabetes mellitus 29.4 IGF1 INS LEP SHBG
12 hyperinsulinism 29.2 IGF1 INS LEP SHBG
13 glucose intolerance 29.2 IGF1 INS LEP SHBG
14 amenorrhea 28.4 BMP15 FSHB FSHR GNRH1 LEP PRL
15 ovarian disease 27.4 BMP15 CGA CYP19A1 FSHR GNRH1 IGF1
16 resistance to lh 11.0
17 hyperproinsulinemia 10.4 INS SHBG
18 seborrheic dermatitis 10.4 CGA SHBG
19 pelvic varices 10.4 GNRH1 SHBG
20 penis agenesis 10.4 CGA GNRH1
21 prostatic adenoma 10.4 PRL SHBG
22 endometriosis of uterus 10.4 GNRH1 PRL
23 hypoactive sexual desire disorder 10.4 CYP19A1 SHBG
24 hypothalamic disease 10.4 GNRH1 PRL
25 chiasmal syndrome 10.4 GNRH1 PRL
26 androgen insensitivity, partial 10.4 CYP19A1 SHBG
27 luteoma 10.4 CGA CYP19A1
28 fetal erythroblastosis 10.4 INS SHBG
29 secondary adrenal insufficiency 10.4 IGF1 INS
30 alopecia, androgenetic, 1 10.4 CYP19A1 SHBG
31 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.3 IGF1 INS
32 galactorrhea 10.3 IGF1 PRL
33 pseudohypoparathyroidism, type ia 10.3 IGF1 PRL
34 granulosa cell tumor of the ovary 10.3 INS PRL
35 intermittent explosive disorder 10.3 CGA PRL
36 pituitary adenoma 1, multiple types 10.3 IGF1 PRL
37 lipodystrophy, familial partial, type 2 10.3 INS LEP
38 donohue syndrome 10.3 IGF1 INS
39 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.3 INS LEP
40 sebaceous gland disease 10.3 IGF1 SHBG
41 sexual disorder 10.3 PRL SHBG
42 hypothyroidism, congenital, nongoitrous, 4 10.2 IGF1 PRL
43 pituitary apoplexy 10.2 GNRH1 INS PRL
44 empty sella syndrome 10.2 GNRH1 INS PRL
45 complete androgen insensitivity syndrome 10.2 CGA CYP19A1 SHBG
46 chromophobe adenoma 10.2 GNRH1 INS PRL
47 central nervous system organ benign neoplasm 10.2 IGF1 PRL
48 pituitary-dependent cushing's disease 10.2 GNRH1 INS PRL
49 precocious puberty, male-limited 10.2 CYP19A1 FSHR
50 abdominal obesity-metabolic syndrome 1 10.2 INS LEP

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to Anovulation

Symptoms & Phenotypes for Anovulation

GenomeRNAi Phenotypes related to Anovulation according to GeneCards Suite gene sharing:

25 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.62 IGF1 LEP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.62 LEP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.62 IGF1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.62 IGF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.62 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.62 IGF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.62 SHBG
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.62 IGF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.62 BMP15
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.62 IGF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.62 LEP SHBG BMP15 IGF1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.62 LEP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.62 IGF1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.62 LEP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.62 IGF1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.62 BMP15

MGI Mouse Phenotypes related to Anovulation:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.17 LEP PRL GNRH1 BMP15 CGA IGF1
2 homeostasis/metabolism MP:0005376 10.1 LEP PRL GNRH1 CGA IGF1 CYP19A1
3 immune system MP:0005387 9.97 PRL LEP AMHR2 GNRH1 IGF1 CYP19A1
4 integument MP:0010771 9.92 LEP PRL GNRH1 IGF1 CYP19A1 INS
5 adipose tissue MP:0005375 9.85 INS LEP IGF1 CYP19A1 FSHR
6 nervous system MP:0003631 9.76 PRL LEP GNRH1 CGA IGF1 CYP19A1
7 neoplasm MP:0002006 9.73 LEP PRL AMHR2 GNRH1 IGF1 FSHR
8 renal/urinary system MP:0005367 9.43 LEP AMHR2 GNRH1 IGF1 CYP19A1 INS
9 reproductive system MP:0005389 9.36 LEP PRL BMP15 CGA IGF1 CYP19A1

Drugs & Therapeutics for Anovulation

Drugs for Anovulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 657-24-9 4091 14219
2
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
3
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
4
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3 71-58-9
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 50-28-2 5757
6
Zinc Approved, Investigational Phase 4,Early Phase 1 7440-66-6 32051 23994
7
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 112809-51-5 3902
8
Menotropins Approved Phase 4,Phase 1,Phase 2 9002-68-0, 61489-71-2 5360545
9
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
10
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
11
Drospirenone Approved Phase 4 67392-87-4 68873
12 Piracetam Approved, Investigational Phase 4 7491-74-9
13
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 77-92-9 311
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
15
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
16
Enclomiphene Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 15690-57-0
17 Etiracetam Investigational Phase 4 33996-58-6
18 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Chelating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Clomiphene Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Fertility Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
30 Selective Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Zuclomiphene Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Androgen Antagonists Phase 4,Phase 2
33 Androgens Phase 4,Phase 2,Early Phase 1
34 Contraceptive Agents Phase 4,Phase 3
35 Contraceptive Agents, Male Phase 4,Phase 3
36 Contraceptives, Oral Phase 4,Phase 3
37
Cyproterone Phase 4 2098-66-0 5284537
38 Progestins Phase 4,Phase 3,Phase 2,Early Phase 1
39 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
40
Medroxyprogesterone Phase 4,Phase 3 520-85-4 10631
41 Tin Fluorides Phase 4,Phase 3
42 insulin Phase 4,Phase 3,Phase 2,Early Phase 1
43 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Early Phase 1
44 Estradiol 17 beta-cypionate Phase 4,Phase 3,Early Phase 1
45 Estradiol 3-benzoate Phase 4,Phase 3,Early Phase 1
46 Estradiol valerate Phase 4,Phase 3,Early Phase 1 979-32-8
47 Polyestradiol phosphate Phase 4,Phase 3,Early Phase 1
48 Aromatase Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
49 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
50 Contraceptives, Oral, Combined Phase 4

Interventional clinical trials:

(show top 50) (show all 151)

# Name Status NCT ID Phase Drugs
1 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
2 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
3 Metformin in Infertile PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
4 PCOS, Therapy and Markers of Cardiovascular Risk Unknown status NCT01798875 Phase 4 oral metformin;oral contraceptive
5 Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility Completed NCT01250821 Phase 4 Menopur
6 Study of Mechanisms of Anovulation in Polycystic Ovary Syndrome Completed NCT00492882 Phase 4 usual administration of exogenous recombinant FSH
7 Treatment of Anovulatory Infertility in PCOS Patients Completed NCT00471523 Phase 4 Clomiphene citrate;Metformin
8 Second-Line Treatments for Anovulatory Infertility in PCOS Patients Completed NCT00558077 Phase 4 Metformin plus clomiphene citrate
9 Structured Exercise Training Program Versus Hypocaloric Hyperproteic Diet in Obese Anovulatory Infertile Patients With PCOS Completed NCT00473538 Phase 4
10 Recombinant Follicle Stimulating Hormone (FSH) (Gonal-f®): Use in Ovulation Induction Completed NCT01081626 Phase 4 Recombinant FSH (follitropin alpha)
11 PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene Completed NCT00795808 Phase 4 Metformin;Placebo;Metformin + Clomiphene;Metformin;Clomiphene
12 Endometrial Shedding Prior to Ovulation Induction Pilot Study Completed NCT02340013 Phase 4 Medroxyprogesterone acetate
13 Short-term Structured Exercise Training Program Plus Diet Intervention in Patients With Polycystic Ovary Syndrome (PCOS) Completed NCT01004068 Phase 4 Clomiphene citrate
14 Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients Completed NCT00953355 Phase 4 Folate plus metformin;Placebo plus metformin
15 Efficacy Study of the OV-Watch™ Personal Fertility Monitor for Women Using Clomiphene Citrate. Completed NCT00239603 Phase 4
16 N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome Completed NCT02239107 Phase 4 N-Acetyl cysteine
17 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed NCT01360996 Phase 4 3 mg DRSP/20 μg EE
18 Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos. Completed NCT01896492 Phase 4 NAC
19 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
20 Metformin Suspension and Insulin Sensitivity Completed NCT00437333 Phase 4 Metformin cloridrate
21 Aromatase Inhibitor Effects on Ovarian Function During the Follicular and Early Luteal Phase in Women Completed NCT01046578 Phase 4 Letrozole;Letrozole;Letrozole;Letrozole;Letrozole;Letrozole
22 Letrozole Versus Clomifene Citrate for Ovulation Induction Completed NCT00478504 Phase 4 Letrozole;Clomifene citrate
23 Study on Safety and Efficacy of Levetiracetam in the Adjunctive Treatment of Female Subjects With C1 Catamenial Epilepsy Completed NCT00630630 Phase 4 Levetiracetam
24 To Study The Influence Of Genomic Factors On Metabolism And Effects Of Clomiphene In Asian Normogonadotrophic Anovulatory Patients. Recruiting NCT02548039 Phase 4
25 Administration of Single High Dose Letrozole for Ovulation Induction Recruiting NCT02703649 Phase 4 Letrozole
26 Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS Recruiting NCT03252223 Phase 4 Recombinant Follicle Stimulating Hormone
27 Concomitant CC and E2 Versus CC Alone in Ovulation Induction Recruiting NCT02186782 Phase 4 Clomiphene citrate and Estradiol;Clomiphene citrate and Placebo
28 "Stair Step Study" Recruiting NCT03309176 Phase 4 Medroxyprogesterone Acetate 10 MG
29 The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS Active, not recruiting NCT02866786 Phase 4 Metformin;ethinyl estradiol and cyproterone acetate
30 Controlled Ovarian Stimulation Followed by Timed Intercourse or Intrauterine Insemination in Infertile PCOS Patients Suspended NCT00502281 Phase 4 highly purified urinary FSH
31 Pilot Study:Role of Dietary Fiber in PCOS Anovulation Terminated NCT00703092 Phase 4 Fiber-Stat
32 Low-dose Gonal-f® in Ovulation Induction Terminated NCT01871532 Phase 4 Gonal-f®
33 Metformin in Assisted Reproduction-MET-AR-study Terminated NCT00159575 Phase 4 Metformin / Placebo treatment for 4 months
34 Metformin Administration in Infertile Anovulatory PCOS Patients Withdrawn NCT00501787 Phase 4 Metformin
35 Clomiphene Citrate in Infertile PCOS Patients Withdrawn NCT00501839 Phase 4 clomiphene citrate
36 Therapy for Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin Withdrawn NCT00502229 Phase 4 Clomiphene citrate, metformin, highly purified urinary FSH
37 Efficacy of Cyclic DSG Compared With Cyclic MPA for the Treatment of Anovulatory DUB Unknown status NCT02103764 Phase 3 Desogestrel;Medroxyprogesterone acetate
38 The Clinical Trial of Acupuncture Pre-treatment on PCOS Unknown status NCT02491320 Phase 3 Letrozole
39 Phase III Clinical Study of Domestic Recombinant Human Follitropin for Injection to Treat WHO Class II Anovulation Completed NCT02335879 Phase 3
40 Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women Completed NCT01653743 Phase 3 MSJ-0011;urinary hCG (u-hCG);Follitropin alpha
41 A Phase III Clinical Study to Compare the Efficacy and Safety of DA-3801 and That of Gonal-F® Completed NCT01820728 Phase 3 DA-3801 Injection;Gonal-F®
42 The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women Completed NCT00413179 Phase 3 Metformin;Clomiphene citrate;Placebo
43 Letrozole vs. Clomiphene Citrate in Patients With Anovulatory Infertility Completed NCT00610077 Phase 3 Letrozole;Clomiphene citrate
44 Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females Completed NCT01923194 Phase 3 Highly Purified Urofollitropin;Recombinant Human Follitropin Alfa
45 Ovarian Laser Treatment in Women With Polycystic Ovarian Syndrome: A Randomized Study on the Laser Dose Completed NCT00643708 Phase 3
46 Traditional Clomiphene Citrate Administration vs. Stair-step Approach Completed NCT01008319 Phase 3 clomiphene citrate;clomiphene citrate
47 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH Completed NCT00296465 Phase 2, Phase 3 Pulsatile gonadotropin-releasing hormone (GnRH);Clomiphene Citrate;Placebo Pulsatile GnRH;Placebo Clomiphene Citrate
48 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed NCT01185782 Phase 3 Gonalef® (Follitropin alfa);Purified pituitary gonadotropin (Fertinorm-P®)
49 Myo-inositol and Melatonin in Pre-menopausal Women Completed NCT01115127 Phase 2, Phase 3
50 Thermosensitive Gels for the Vaginal Delivery of Sildenafil Citrate Completed NCT02766725 Phase 2, Phase 3 preparation F12 sildenafil in situ gel;preparation F2 sildenafil in situ gel;placebo gel

Search NIH Clinical Center for Anovulation

Cochrane evidence based reviews: anovulation

Genetic Tests for Anovulation

Anatomical Context for Anovulation

MalaCards organs/tissues related to Anovulation:

38
Ovary, Pituitary, Liver, Testes, Brain, Bone, Breast

Publications for Anovulation

Articles related to Anovulation:

(show top 50) (show all 330)
# Title Authors Year
1
Altered expression of IL-1I^, IL-1RI, IL-1RII, IL-1RA and IL-4 could contribute to anovulation and follicular persistence in cattle. ( 29334661 )
2018
2
Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 29210151 )
2018
3
C-Reactive protein in relation to fecundability and anovulation among eumenorrheic women. ( 29317123 )
2018
4
Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 29226510 )
2018
5
Phase III trial comparing the efficacy and safety of recombinant- or urine-derived human chorionic gonadotropin for ovulation triggering in Japanese women diagnosed with anovulation or oligo-ovulation and undergoing ovulation induction with follitropin-alfa. ( 29259450 )
2017
6
Rates of Anovulation in Adolescents and Young Adults with Moderate to Severe Primary Dysmenorrhea and Those without Primary Dysmenorrhea. ( 29017868 )
2017
7
Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28815914 )
2017
8
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis. ( 28143834 )
2017
9
Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice. ( 28432106 )
2017
10
Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): a randomised, two-by-two factorial trial. ( 29273245 )
2017
11
Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28544572 )
2017
12
Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28815934 )
2017
13
Metformin for women with hyperandrogenic anovulation. ( 26906093 )
2016
14
Reply: Metformin for women with hyperandrogenic anovulation. ( 26906091 )
2016
15
Dairy Food Intake Is Associated with Reproductive Hormones and Sporadic Anovulation among Healthy Premenopausal Women. ( 27881593 )
2016
16
Subfertility in rheumatoid arthritis is often unexplained or caused by anovulation. ( 27723275 )
2016
17
Low-dose aspirin and sporadic anovulation in the EAGeR randomized trial. ( 27754808 )
2016
18
Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study. ( 27225433 )
2016
19
Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries. ( 26040673 )
2015
20
Loss of Body Fat and Associated Decrease in Leptin in Early Lactation Are Related to Shorter Duration of Postpartum Anovulation in Healthy US Women. ( 25596410 )
2015
21
Role of cortisol and superoxide dismutase in psychological stress induced anovulation. ( 26393311 )
2015
22
Non-reproductive Effects of Anovulation: Bone Metabolism in the Luteal Phase of Premenopausal Women Differs between Ovulatory and Anovulatory Cycles. ( 26726266 )
2015
23
Prevalence of conditions causing chronic anovulation and the proposed algorithm for anovulation evaluation. ( 25772812 )
2015
24
Factors associated with nonresponse to ovulation induction using letrozole among women with World Health Organization group II anovulation. ( 26157297 )
2015
25
Individual and combined effects of anovulation and cytological endometritis on the reproductive performance of dairy cows. ( 24996269 )
2014
26
Visceral adiposity index (VAI) is related to the severity of anovulation and other clinical features in women with polycystic ovary syndrome. ( 24601936 )
2014
27
Examining the ovaries by ultrasound for diagnosing hyperandrogenic anovulation: updating the threshold for newer machines. ( 24534278 )
2014
28
Cost-effectiveness analysis on the use of rFSH + rLH for the treatment of anovulation in hypogonadotropic hypogonadal women. ( 25028553 )
2014
29
Depressive symptoms and their relationship with endogenous reproductive hormones and sporadic anovulation in premenopausal women. ( 25453349 )
2014
30
The role of AMH in anovulation associated with PCOS: a hypothesis. ( 24770999 )
2014
31
Counting ovarian follicles: updated threshold for diagnosis of hyperandrogenic anovulation. ( 25088509 )
2014
32
Terms and thresholds for the ultrasound evaluation of the ovaries in women with hyperandrogenic anovulation. ( 24516084 )
2014
33
Increased androgen, anti-MA1llerian hormone, and sporadic anovulation in healthy, eumenorrheic women: a mild PCOS-like phenotype? ( 24606085 )
2014
34
Accounting for Anovulation and Vaginal Thinning During Depot Medroxyprogesterone Acetate Use. ( 25217405 )
2014
35
Assessment of anovulation in eumenorrheic women: comparison of ovulation detection algorithms. ( 24875398 )
2014
36
Pregnancy complications and metabolic disease in women with clomiphene citrate-resistant anovulation randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotropins: a 10-year follow-up. ( 24268702 )
2014
37
Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. ( 24169550 )
2014
38
Willingness to pay for ovulation induction treatment in case of WHO II anovulation: a study using the contingent valuation method. ( 25328385 )
2014
39
Serum zonulin is elevated in women with polycystic ovary syndrome, and correlates with insulin resistance and severity of anovulation. ( 25336505 )
2014
40
The influence of sporadic anovulation on hormone levels in ovulatory cycles. ( 23589536 )
2013
41
Clinical review: Adolescent anovulation: maturational mechanisms and implications. ( 23913942 )
2013
42
Loss of LH-induced down-regulation of anti-MA1llerian hormone receptor expression may contribute to anovulation in women with polycystic ovary syndrome. ( 23321213 )
2013
43
The M-OVIN study: does switching treatment to FSH and / or IUI lead to higher pregnancy rates in a subset of women with world health organization type II anovulation not conceiving after six ovulatory cycles with clomiphene citrate - a randomised controlled trial. ( 24160333 )
2013
44
British Fertility Society. 'Ovulation induction in WHO Type 1 anovulation: Guidelines for practice'. Produced on behalf of the BFS Policy and Practice Committee. ( 24245485 )
2013
45
Progestogens with or without oestrogen for irregular uterine bleeding associated with anovulation. ( 22972055 )
2012
46
Risk factors and effects of postpartum anovulation in dairy cows. ( 22459832 )
2012
47
Clomifene citrate or low-dose FSH for the first-line treatment of infertile women with anovulation associated with polycystic ovary syndrome: a prospective randomized multinational study. ( 22128296 )
2012
48
Balancing ovulation and anovulation: integration of the reproductive and energy balance axes by neuropeptides. ( 22442260 )
2012
49
Efficacy of different gonadotropin combinations to support ovulation induction in WHO type I anovulation infertility: clinical evidences of human recombinant FSH/human recombinant LH in a 2:1 ratio and highly purified human menopausal gonadotropin stimulation protocols. ( 23095369 )
2012
50
Chinese herbal medicine for infertility with anovulation: a systematic review. ( 23198826 )
2012

Variations for Anovulation

Expression for Anovulation

Search GEO for disease gene expression data for Anovulation.

Pathways for Anovulation

Pathways related to Anovulation according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CGA FSHB FSHR GNRH1 LEP PRL
2
Show member pathways
12.38 CGA FSHB GNRH1 IGF1
3
Show member pathways
12.16 CGA INS LEP PRL
4
Show member pathways
11.91 CGA FSHB IGF1 INS LEP
5 11.85 CGA FSHB FSHR
6 11.75 IGF1 INS LEP
7 11.59 IGF1 INS LEP
8 11.24 INS LEP PRL
9 11.15 CGA CYP19A1 IGF1
10 11.04 CYP19A1 FSHR
11 10.89 FSHB FSHR
12 10.89 CGA CYP19A1 FSHB FSHR
13 10.87 BMP15 CGA CYP19A1 FSHB FSHR IGF1
14 10.73 GNRH1 SHBG
15 10.37 CGA FSHB FSHR GNRH1

GO Terms for Anovulation

Cellular components related to Anovulation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 BMP15 FSHB GNRH1 IGF1 INS LEP
2 extracellular region GO:0005576 9.28 BMP15 CGA FSHB GNRH1 IGF1 INS
3 endosome lumen GO:0031904 8.96 INS PRL

Biological processes related to Anovulation according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.89 CGA FSHB IGF1 INS LEP
2 cell-cell signaling GO:0007267 9.81 CGA FSHB GNRH1 INS
3 cellular protein metabolic process GO:0044267 9.78 BMP15 IGF1 INS PRL
4 positive regulation of MAPK cascade GO:0043410 9.7 IGF1 INS LEP
5 positive regulation of cell migration GO:0030335 9.67 CGA FSHB IGF1 INS
6 activation of protein kinase B activity GO:0032148 9.63 IGF1 INS
7 hormone-mediated signaling pathway GO:0009755 9.63 FSHB FSHR
8 positive regulation of glucose import GO:0046326 9.62 IGF1 INS
9 regulation of multicellular organism growth GO:0040014 9.62 IGF1 PRL
10 positive regulation of mitotic nuclear division GO:0045840 9.61 IGF1 INS
11 peptide hormone processing GO:0016486 9.61 CGA FSHB
12 positive regulation of glycolytic process GO:0045821 9.6 IGF1 INS
13 positive regulation of JAK-STAT cascade GO:0046427 9.59 LEP PRL
14 uterus development GO:0060065 9.58 CYP19A1 FSHR
15 regulation of osteoclast differentiation GO:0045670 9.58 FSHB FSHR
16 positive regulation of glycogen biosynthetic process GO:0045725 9.57 IGF1 INS
17 positive regulation of insulin receptor signaling pathway GO:0046628 9.56 INS LEP
18 gonad development GO:0008406 9.55 CGA FSHR
19 female gonad development GO:0008585 9.5 AMHR2 CYP19A1 FSHR
20 Sertoli cell proliferation GO:0060011 9.46 FSHB FSHR
21 female pregnancy GO:0007565 9.46 FSHB GNRH1 LEP PRL
22 bone mineralization involved in bone maturation GO:0035630 9.43 IGF1 LEP
23 female gamete generation GO:0007292 9.43 BMP15 FSHB FSHR
24 follicle-stimulating hormone signaling pathway GO:0042699 9.4 FSHB FSHR
25 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.26 FSHR IGF1 INS LEP
26 regulation of receptor activity GO:0010469 9.23 BMP15 CGA FSHB GNRH1 IGF1 INS
27 signal transduction GO:0007165 10.08 AMHR2 CGA FSHB FSHR GNRH1 IGF1

Molecular functions related to Anovulation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 BMP15 IGF1 LEP
2 insulin receptor binding GO:0005158 9.26 IGF1 INS
3 hormone activity GO:0005179 9.17 CGA FSHB GNRH1 IGF1 INS LEP
4 insulin-like growth factor receptor binding GO:0005159 8.96 IGF1 INS

Sources for Anovulation

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