MCID: ANV001
MIFTS: 44

Anovulation

Categories: Reproductive diseases

Aliases & Classifications for Anovulation

MalaCards integrated aliases for Anovulation:

Name: Anovulation 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3781
MeSH 42 D000858
NCIt 47 C34388
SNOMED-CT 64 34571000
UMLS 69 C0003128

Summaries for Anovulation

MalaCards based summary : Anovulation is related to endometriosis and polycystic ovary syndrome. An important gene associated with Anovulation is SHBG (Sex Hormone Binding Globulin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Development Endothelin-1/EDNRA signaling. The drugs Cyproterone Acetate and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and endocrine/exocrine gland

Wikipedia : 72 Anovulation is when the ovaries do not release an oocyte during a menstrual cycle. Therefore, ovulation... more...

Related Diseases for Anovulation

Diseases related to Anovulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
id Related Disease Score Top Affiliating Genes
1 endometriosis 30.7 PRL SHBG
2 polycystic ovary syndrome 11.2
3 resistance to lh 10.8
4 vaginal discharge 10.7 CGA SHBG
5 maturity-onset diabetes of the young, type 10 10.7 INS SHBG
6 contagious pustular dermatitis 10.6 CGA SHBG
7 african histoplasmosis 10.6 GNRH1 PRL
8 pepck 1 deficiency 10.6 CGA GNRH1
9 prostate leiomyoma 10.6 GNRH1 PRL
10 polyneuropathy 10.6 CYP19A1 SHBG
11 adenomatoid tumor 10.6 GNRH1 PRL
12 osteopathia striata with cranial sclerosis 10.6 CYP19A1 SHBG
13 intermittent squint 10.6 GNRH1 PRL
14 lymphoepithelioma-like carcinoma 10.6 GNRH1 PRL
15 ocular hypotension 10.6 CGA CYP19A1
16 selenium poisoning 10.5 IGF1 INS
17 epilepsy, idiopathic generalized 11 10.5 CYP19A1 SHBG
18 group b strep disease in newborns 10.5 INS PRL
19 conjunctival vascular disease 10.5 INS SHBG
20 lipodystrophy, familial partial, type 2 10.4 INS LEP
21 hyperlipoproteinemia, type ib 10.4 IGF1 INS
22 granuloma inguinale 10.4 IGF1 SHBG
23 myh-9 related disease 10.4 INS LEP
24 internal hemorrhoid 10.4 GNRH1 PRL SHBG
25 uterine corpus adenocarcinofibroma 10.4 GNRH1 PRL SHBG
26 vertebral artery occlusion 10.4 GNRH1 INS PRL
27 lactic acidosis 10.4 GNRH1 INS PRL
28 hypothyroidism, congenital, nongoitrous 4 10.4 IGF1 PRL
29 condrodisplasia punctata rizomélica 10.4 CGA CYP19A1 SHBG
30 immune system organ benign neoplasm 10.4 IGF1 PRL
31 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.4 CGA GNRH1 SHBG
32 tinf2-related dyskeratosis congenita 10.4 IGF1 INS
33 retinitis pigmentosa 46 10.4 GNRH1 PRL
34 diencephalic neoplasm 10.4 GNRH1 INS PRL
35 androgen insensitivity, partial, with or without breast cancer 10.4 CGA CYP19A1 SHBG
36 acute myocarditis 10.4 GNRH1 INS PRL
37 munchausen by proxy 10.4 PRL SHBG
38 precocious puberty, male 10.4 CYP19A1 FSHR
39 pituitary adenoma, prolactin-secreting 10.4 IGF1 PRL
40 hypomagnesemia 3, renal 10.3 INS LEP
41 glomerulosclerosis, focal segmental, 1 10.3 IGF1 INS
42 glioblastoma proneural subtype 10.3 CYP19A1 PRL SHBG
43 thymus mucoepidermoid carcinoma 10.3 BMP15 GNRH1
44 aromatase excess syndrome 10.3 CYP19A1 GNRH1 INS
45 osseous heteroplasia, progressive 10.3 IGF1 PRL
46 luxation of globe 10.3 CGA PRL
47 medullomyoblastoma 10.3 GNRH1 IGF1 SHBG
48 renal-hepatic-pancreatic dysplasia 10.3 CGA GNRH1 IGF1
49 hyperandrogenism 10.3
50 algoneurodystrophy 10.3 IGF1 INS

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to Anovulation

Symptoms & Phenotypes for Anovulation

GenomeRNAi Phenotypes related to Anovulation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.62 IGF1 LEP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.62 LEP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.62 IGF1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.62 IGF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.62 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.62 IGF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.62 SHBG
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.62 IGF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.62 BMP15
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.62 IGF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.62 BMP15 IGF1 LEP SHBG
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.62 LEP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.62 IGF1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.62 LEP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.62 IGF1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.62 BMP15

MGI Mouse Phenotypes related to Anovulation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.17 GNRH1 IGF1 INS LEP PRL AMHR2
2 homeostasis/metabolism MP:0005376 10.1 AMHR2 CGA CYP19A1 FSHB FSHR GNRH1
3 immune system MP:0005387 9.97 IGF1 INS LEP PRL AMHR2 CYP19A1
4 integument MP:0010771 9.92 AMHR2 CYP19A1 FSHR GNRH1 IGF1 INS
5 adipose tissue MP:0005375 9.85 CYP19A1 FSHR IGF1 INS LEP
6 nervous system MP:0003631 9.76 CGA CYP19A1 FSHR GNRH1 IGF1 INS
7 neoplasm MP:0002006 9.73 AMHR2 FSHR GNRH1 IGF1 LEP PRL
8 renal/urinary system MP:0005367 9.43 AMHR2 CYP19A1 GNRH1 IGF1 INS LEP
9 reproductive system MP:0005389 9.36 AMHR2 BMP15 CGA CYP19A1 FSHB FSHR

Drugs & Therapeutics for Anovulation

Drugs for Anovulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 144)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
2
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
3
Metformin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 657-24-9 14219 4091
4
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3 71-58-9
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1 50-28-2 5757
6
Letrozole Approved, Investigational Phase 4,Phase 2,Early Phase 1 112809-51-5 3902
7
Menotropins Approved Phase 4,Phase 1,Phase 2 61489-71-2, 9002-68-0 5360545
8
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
9
Drospirenone Approved Phase 4 67392-87-4 68873
10
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
12
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
13
Enclomiphene Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 15690-57-0
14 Androgen Antagonists Phase 4,Phase 2
15 Androgens Phase 4,Phase 2,Early Phase 1
16 Contraceptive Agents Phase 4,Phase 3
17 Contraceptive Agents, Male Phase 4,Phase 3
18 Contraceptives, Oral Phase 4,Phase 3
19
Cyproterone Phase 4 2098-66-0 5284537
20 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
24 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Chelating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Clomiphene Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Fertility Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Selective Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Zuclomiphene Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Progestins Phase 4,Phase 3,Early Phase 1
35 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
36
Medroxyprogesterone Phase 4,Phase 3 520-85-4 10631
37 Tin Fluorides Phase 4,Phase 3
38 Estradiol 17 beta-cypionate Phase 4,Phase 3,Early Phase 1
39 Estradiol 3-benzoate Phase 4,Phase 3,Early Phase 1
40 Estradiol valerate Phase 4,Phase 3,Early Phase 1 979-32-8
41 Polyestradiol phosphate Phase 4,Phase 3,Early Phase 1
42 insulin Phase 4,Phase 3,Phase 2,Early Phase 1
43 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Early Phase 1
44 Aromatase Inhibitors Phase 4,Phase 2,Early Phase 1
45 Steroid Synthesis Inhibitors Phase 4,Phase 2,Early Phase 1
46 Contraceptives, Oral, Combined Phase 4
47 Chorionic Gonadotropin Phase 4,Phase 3,Phase 2,Phase 1
48 Follicle Stimulating Hormone Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Hematinics Phase 4
50 Micronutrients Phase 4

Interventional clinical trials:

(show top 50) (show all 113)

id Name Status NCT ID Phase Drugs
1 PCOS, Therapy and Markers of Cardiovascular Risk Unknown status NCT01798875 Phase 4 oral metformin;oral contraceptive
2 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
3 Study of Mechanisms of Anovulation in Polycystic Ovary Syndrome Completed NCT00492882 Phase 4 usual administration of exogenous recombinant FSH
4 Treatment of Anovulatory Infertility in PCOS Patients Completed NCT00471523 Phase 4 Clomiphene citrate;Metformin
5 Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility Completed NCT01250821 Phase 4 Menopur
6 Short-term Structured Exercise Training Program Plus Diet Intervention in Patients With Polycystic Ovary Syndrome (PCOS) Completed NCT01004068 Phase 4 Clomiphene citrate
7 Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients Completed NCT00953355 Phase 4 Folate plus metformin;Placebo plus metformin
8 Efficacy Study of the OV-Watch™ Personal Fertility Monitor for Women Using Clomiphene Citrate. Completed NCT00239603 Phase 4
9 Second-Line Treatments for Anovulatory Infertility in PCOS Patients Completed NCT00558077 Phase 4 Metformin plus clomiphene citrate
10 Structured Exercise Training Program Versus Hypocaloric Hyperproteic Diet in Obese Anovulatory Infertile Patients With PCOS Completed NCT00473538 Phase 4
11 Recombinant Follicle Stimulating Hormone (FSH) (Gonal-f®): Use in Ovulation Induction Completed NCT01081626 Phase 4 Recombinant FSH (follitropin alpha)
12 Endometrial Shedding Prior to Ovulation Induction Pilot Study Completed NCT02340013 Phase 4 Medroxyprogesterone acetate
13 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed NCT01360996 Phase 4 3 mg DRSP/20 μg EE
14 N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome Completed NCT02239107 Phase 4 N-Acetyl cysteine
15 Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos. Completed NCT01896492 Phase 4 NAC
16 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
17 Letrozole Versus Clomifene Citrate for Ovulation Induction Completed NCT00478504 Phase 4 Letrozole;Clomifene citrate
18 PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene Completed NCT00795808 Phase 4 Metformin;Placebo;Metformin + Clomiphene;Metformin;Clomiphene
19 Administration of Single High Dose Letrozole for Ovulation Induction Recruiting NCT02703649 Phase 4 Letrozole
20 Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS Recruiting NCT03252223 Phase 4 Recombinant Follicle Stimulating Hormone
21 Concomitant CC and E2 Versus CC Alone in Ovulation Induction Recruiting NCT02186782 Phase 4 Clomiphene citrate and Estradiol;Clomiphene citrate and Placebo
22 Metformin in Infertile PCOS Patients Recruiting NCT00501904 Phase 4 Metformin
23 The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS Active, not recruiting NCT02866786 Phase 4 Metformin;ethinyl estradiol and cyproterone acetate
24 Pilot Study:Role of Dietary Fiber in PCOS Anovulation Terminated NCT00703092 Phase 4 Fiber-Stat
25 Low-dose Gonal-f® in Ovulation Induction Terminated NCT01871532 Phase 4 Gonal-f®
26 Metformin in Assisted Reproduction-MET-AR-study Terminated NCT00159575 Phase 4 Metformin / Placebo treatment for 4 months
27 Metformin Administration in Infertile Anovulatory PCOS Patients Withdrawn NCT00501787 Phase 4 Metformin
28 Clomiphene Citrate in Infertile PCOS Patients Withdrawn NCT00501839 Phase 4 clomiphene citrate
29 Efficacy of Cyclic DSG Compared With Cyclic MPA for the Treatment of Anovulatory DUB Unknown status NCT02103764 Phase 3 Desogestrel;Medroxyprogesterone acetate
30 Phase III Clinical Study of Domestic Recombinant Human Follitropin for Injection to Treat WHO Class II Anovulation Completed NCT02335879 Phase 3
31 A Phase III Clinical Study to Compare the Efficacy and Safety of DA-3801 and That of Gonal-F® Completed NCT01820728 Phase 3 DA-3801 Injection;Gonal-F®
32 Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women Completed NCT01653743 Phase 3 MSJ-0011;urinary hCG (u-hCG);Follitropin alpha
33 Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females Completed NCT01923194 Phase 3 Highly Purified Urofollitropin;Recombinant Human Follitropin Alfa
34 Traditional Clomiphene Citrate Administration vs. Stair-step Approach Completed NCT01008319 Phase 3 clomiphene citrate;clomiphene citrate
35 Ovarian Laser Treatment in Women With Polycystic Ovarian Syndrome: A Randomized Study on the Laser Dose Completed NCT00643708 Phase 3
36 The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women Completed NCT00413179 Phase 3 Metformin;Clomiphene citrate;Placebo
37 Thermosensitive Gels for the Vaginal Delivery of Sildenafil Citrate Completed NCT02766725 Phase 2, Phase 3 preparation F12 sildenafil in situ gel;preparation F2 sildenafil in situ gel;placebo gel
38 Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS Completed NCT01482286 Phase 3 Metformin
39 Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS ) Unknown status NCT02551367 Phase 2 Letrozole;Clomiphene citrate;hcg hormone
40 Comparison of Anastrozole Verses Clomiphene Citrate in Stimulating Follicular Growth and Ovulation in Infertile Women With Ovulatory Dysfunction Completed NCT00213148 Phase 2 Anastrozole 1mg;Anastrozole 5mg dose;Anastrozole 10mg dose;Clomiphene Citrate 50mg
41 Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome Completed NCT00947713 Phase 1, Phase 2 low dose human chorionic gonadotropin;Clomiphen citrate plus HMG
42 Serum Anti-mullerian Hormone and Polycystic Ovarian Syndrome Completed NCT03237312 Phase 2
43 Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome Patients Completed NCT02562664 Phase 2 CC;Placebo tablets;Metformin
44 Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS) Completed NCT00151411 Phase 2 Metformin;Placebo
45 Clomiphene Citrate Plus Cabergoline in Treatment of Polycystic Ovary Syndrome Recruiting NCT02644304 Phase 2 Clomiphene citrate;Cabergoline
46 Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women Recruiting NCT01889199 Phase 2 Flutamide
47 Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction Not yet recruiting NCT03229408 Phase 2 Salsalate
48 AS900672-Enriched in Ovulation Induction Terminated NCT00553514 Phase 2 AS900672-Enriched 10 microgram (mcg);AS900672-Enriched 20 mcg;AS900672-Enriched 30 mcg;AS900672-Enriched 40 mcg;Follitropin alfa 75 international unit (IU);Recombinant human chorionic gonadotropin (r-hCG)
49 Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene Completed NCT01289756 Phase 1 Clomiphene;clomiphene and paroxetine;clomiphene and clarithromycin
50 Bioequivalence Trial of Liquid Versus Freeze-Dried Pergoveris® in Pituitary Suppressed Healthy Premenopausal Female Subjects Completed NCT02317809 Phase 1 Liquid pergoveris;Freeze-dried pergoveris

Search NIH Clinical Center for Anovulation

Cochrane evidence based reviews: anovulation

Genetic Tests for Anovulation

Anatomical Context for Anovulation

MalaCards organs/tissues related to Anovulation:

39
Ovary, Pituitary, Liver, Testes, Brain, Bone, Breast

Publications for Anovulation

Articles related to Anovulation:

(show top 50) (show all 323)
id Title Authors Year
1
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis. ( 28143834 )
2017
2
Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28815934 )
2017
3
Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28544572 )
2017
4
Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice. ( 28432106 )
2017
5
Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28815914 )
2017
6
Metformin for women with hyperandrogenic anovulation. ( 26906093 )
2016
7
Subfertility in rheumatoid arthritis is often unexplained or caused by anovulation. ( 27723275 )
2016
8
Reply: Metformin for women with hyperandrogenic anovulation. ( 26906091 )
2016
9
Low-dose aspirin and sporadic anovulation in the EAGeR randomized trial. ( 27754808 )
2016
10
Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study. ( 27225433 )
2016
11
Dairy Food Intake Is Associated with Reproductive Hormones and Sporadic Anovulation among Healthy Premenopausal Women. ( 27881593 )
2016
12
Loss of Body Fat and Associated Decrease in Leptin in Early Lactation Are Related to Shorter Duration of Postpartum Anovulation in Healthy US Women. ( 25596410 )
2015
13
Prevalence of conditions causing chronic anovulation and the proposed algorithm for anovulation evaluation. ( 25772812 )
2015
14
Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries. ( 26040673 )
2015
15
Factors associated with nonresponse to ovulation induction using letrozole among women with World Health Organization group II anovulation. ( 26157297 )
2015
16
Non-reproductive Effects of Anovulation: Bone Metabolism in the Luteal Phase of Premenopausal Women Differs between Ovulatory and Anovulatory Cycles. ( 26726266 )
2015
17
Role of cortisol and superoxide dismutase in psychological stress induced anovulation. ( 26393311 )
2015
18
Pregnancy complications and metabolic disease in women with clomiphene citrate-resistant anovulation randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotropins: a 10-year follow-up. ( 24268702 )
2014
19
Counting ovarian follicles: updated threshold for diagnosis of hyperandrogenic anovulation. ( 25088509 )
2014
20
Assessment of anovulation in eumenorrheic women: comparison of ovulation detection algorithms. ( 24875398 )
2014
21
Examining the ovaries by ultrasound for diagnosing hyperandrogenic anovulation: updating the threshold for newer machines. ( 24534278 )
2014
22
Accounting for Anovulation and Vaginal Thinning During Depot Medroxyprogesterone Acetate Use. ( 25217405 )
2014
23
The role of AMH in anovulation associated with PCOS: a hypothesis. ( 24770999 )
2014
24
Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. ( 24169550 )
2014
25
Visceral adiposity index (VAI) is related to the severity of anovulation and other clinical features in women with polycystic ovary syndrome. ( 24601936 )
2014
26
Terms and thresholds for the ultrasound evaluation of the ovaries in women with hyperandrogenic anovulation. ( 24516084 )
2014
27
Cost-effectiveness analysis on the use of rFSH + rLH for the treatment of anovulation in hypogonadotropic hypogonadal women. ( 25028553 )
2014
28
Individual and combined effects of anovulation and cytological endometritis on the reproductive performance of dairy cows. ( 24996269 )
2014
29
Increased androgen, anti-MA1llerian hormone, and sporadic anovulation in healthy, eumenorrheic women: a mild PCOS-like phenotype? ( 24606085 )
2014
30
Serum zonulin is elevated in women with polycystic ovary syndrome, and correlates with insulin resistance and severity of anovulation. ( 25336505 )
2014
31
Depressive symptoms and their relationship with endogenous reproductive hormones and sporadic anovulation in premenopausal women. ( 25453349 )
2014
32
Willingness to pay for ovulation induction treatment in case of WHO II anovulation: a study using the contingent valuation method. ( 25328385 )
2014
33
Loss of LH-induced down-regulation of anti-MA1llerian hormone receptor expression may contribute to anovulation in women with polycystic ovary syndrome. ( 23321213 )
2013
34
The influence of sporadic anovulation on hormone levels in ovulatory cycles. ( 23589536 )
2013
35
Clinical review: Adolescent anovulation: maturational mechanisms and implications. ( 23913942 )
2013
36
The M-OVIN study: does switching treatment to FSH and / or IUI lead to higher pregnancy rates in a subset of women with world health organization type II anovulation not conceiving after six ovulatory cycles with clomiphene citrate - a randomised controlled trial. ( 24160333 )
2013
37
British Fertility Society. 'Ovulation induction in WHO Type 1 anovulation: Guidelines for practice'. Produced on behalf of the BFS Policy and Practice Committee. ( 24245485 )
2013
38
Risk factors and effects of postpartum anovulation in dairy cows. ( 22459832 )
2012
39
Progestogens with or without oestrogen for irregular uterine bleeding associated with anovulation. ( 22972055 )
2012
40
Clomifene citrate or low-dose FSH for the first-line treatment of infertile women with anovulation associated with polycystic ovary syndrome: a prospective randomized multinational study. ( 22128296 )
2012
41
Balancing ovulation and anovulation: integration of the reproductive and energy balance axes by neuropeptides. ( 22442260 )
2012
42
Efficacy of different gonadotropin combinations to support ovulation induction in WHO type I anovulation infertility: clinical evidences of human recombinant FSH/human recombinant LH in a 2:1 ratio and highly purified human menopausal gonadotropin stimulation protocols. ( 23095369 )
2012
43
Cornual polyps of the fallopian tube are associated with endometriosis and anovulation. ( 22190955 )
2012
44
Chinese herbal medicine for infertility with anovulation: a systematic review. ( 23198826 )
2012
45
Chinese herbal medicine and clomiphene citrate for anovulation: a meta-analysis of randomized controlled trials. ( 21563919 )
2011
46
Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women. ( 21543284 )
2011
47
Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares. ( 21571458 )
2011
48
The subcutaneous abdominal fat and not the intraabdominal fat compartment is associated with anovulation in women with obesity and infertility. ( 20200335 )
2010
49
Aberrant follicle development and anovulation in polycystic ovary syndrome. ( 20362969 )
2010
50
Anovulation with or without PCO, hyperandrogenaemia and hyperinsulinaemia as promoters of endometrial and breast cancer. ( 19264556 )
2010

Variations for Anovulation

Expression for Anovulation

Search GEO for disease gene expression data for Anovulation.

Pathways for Anovulation

Pathways related to Anovulation according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CGA FSHB FSHR GNRH1 LEP PRL
2
Show member pathways
12.48 CGA FSHB GNRH1 IGF1
3
Show member pathways
12.16 CGA INS LEP PRL
4
Show member pathways
11.91 CGA FSHB IGF1 INS LEP
5 11.85 CGA FSHB FSHR
6 11.75 IGF1 INS LEP
7 11.59 IGF1 INS LEP
8 11.24 INS LEP PRL
9 11.15 CGA CYP19A1 IGF1
10 11.04 CYP19A1 FSHR
11 10.89 FSHB FSHR
12 10.89 CGA CYP19A1 FSHB FSHR
13 10.87 BMP15 CGA CYP19A1 FSHB FSHR IGF1
14 10.73 GNRH1 SHBG
15 10.37 CGA FSHB FSHR GNRH1

GO Terms for Anovulation

Cellular components related to Anovulation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 BMP15 FSHB GNRH1 IGF1 INS LEP
2 extracellular region GO:0005576 9.28 BMP15 CGA FSHB GNRH1 IGF1 INS
3 endosome lumen GO:0031904 8.96 INS PRL

Biological processes related to Anovulation according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 CGA FSHB IGF1 INS LEP
2 cell-cell signaling GO:0007267 9.81 CGA FSHB GNRH1 INS
3 cellular protein metabolic process GO:0044267 9.76 BMP15 IGF1 INS PRL
4 positive regulation of MAPK cascade GO:0043410 9.67 IGF1 INS LEP
5 positive regulation of glucose import GO:0046326 9.63 IGF1 INS
6 hormone-mediated signaling pathway GO:0009755 9.62 FSHB FSHR
7 activation of protein kinase B activity GO:0032148 9.62 IGF1 INS
8 positive regulation of cell migration GO:0030335 9.62 CGA FSHB IGF1 INS
9 regulation of multicellular organism growth GO:0040014 9.61 IGF1 PRL
10 positive regulation of mitotic nuclear division GO:0045840 9.61 IGF1 INS
11 peptide hormone processing GO:0016486 9.6 CGA FSHB
12 positive regulation of JAK-STAT cascade GO:0046427 9.59 LEP PRL
13 positive regulation of glycolytic process GO:0045821 9.58 IGF1 INS
14 uterus development GO:0060065 9.58 CYP19A1 FSHR
15 positive regulation of glycogen biosynthetic process GO:0045725 9.57 IGF1 INS
16 regulation of osteoclast differentiation GO:0045670 9.56 FSHB FSHR
17 positive regulation of insulin receptor signaling pathway GO:0046628 9.55 INS LEP
18 gonad development GO:0008406 9.54 CGA FSHR
19 Sertoli cell proliferation GO:0060011 9.43 FSHB FSHR
20 female gonad development GO:0008585 9.43 AMHR2 CYP19A1 FSHR
21 bone mineralization involved in bone maturation GO:0035630 9.4 IGF1 LEP
22 follicle-stimulating hormone signaling pathway GO:0042699 9.37 FSHB FSHR
23 female gamete generation GO:0007292 9.33 BMP15 FSHB FSHR
24 female pregnancy GO:0007565 9.26 FSHB GNRH1 LEP PRL
25 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.92 FSHR IGF1 INS LEP
26 signal transduction GO:0007165 10.07 AMHR2 CGA FSHB FSHR GNRH1 IGF1

Molecular functions related to Anovulation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 BMP15 IGF1 LEP
2 insulin receptor binding GO:0005158 9.26 IGF1 INS
3 hormone activity GO:0005179 9.17 CGA FSHB GNRH1 IGF1 INS LEP
4 insulin-like growth factor receptor binding GO:0005159 8.96 IGF1 INS

Sources for Anovulation

3 CDC
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10 dbSNP
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16 ExPASy
18 FMA
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65 SNOMED-CT via HPO
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67 TGDB
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