MCID: ANX004
MIFTS: 26

Anoxia malady

Summaries for Anoxia

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Sources:
43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

MalaCards: Anoxia is related to ischemia and hepatitis. An important gene associated with Anoxia is ACOX1 (acyl-CoA oxidase 1, palmitoyl), and among its related pathways is Metabolism. The compounds superoxide and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include brain.

Wikipedia:63 The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or \"low... more...

Aliases & Classifications for Anoxia

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43NINDS, 60UMLS
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Aliases & Descriptions:

anoxia 43 60


Related Diseases for Anoxia

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Anoxia:



Diseases related to anoxia

Clinical Features for Anoxia

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Drugs & Therapeutics for Anoxia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Anoxia

Search NIH Clinical Center for Anoxia

Search CenterWatch for Anoxia

Genetic Tests for Anoxia

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Anatomical Context for Anoxia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Anoxia:

32
Brain

Animal Models for Anoxia or affiliated genes

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Publications for Anoxia

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Genetic Variations for Anoxia

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Expression for genes affiliated with Anoxia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anoxia

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Pathways for genes affiliated with Anoxia

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53Reactome, 29KEGG
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Pathways related to Anoxia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4GSS, ADH1A, SMPD1, ACOX1, GPC4

Compounds for genes affiliated with Anoxia

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB
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Compounds related to Anoxia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1superoxide44 2411.6KCNJ5, AKR1A1, LTB4R, NGB, ACOX1, SMPD1
2fatty acid4410.6LTB4R, ACOX1, SERPINA6, ADCYAP1, GSS
3histidine4410.6NGB, CYGB, ACOX1, ADCYAP1
4h2o24410.6AKR1A1, NGB, CYGB, ACOX1, SMPD1, ADCYAP1
5atp44 2811.6HSPA14, KCNJ5, LTB4R, SLC8A2, ACOX1, SMPD1
6nitric oxide44 11 2412.5HSPA14, KCNJ5, LTB4R, NGB, CYGB, SMPD1
7glucose4410.5HSPA14, KCNJ5, TRIB3, MAP4K2, NGB, SERPINA6
8adp44 28 2412.5KCNJ5, STK25, MAP4K2, LTB4R, SMPD1, GSS
9lipid4410.5KCNJ5, AKR1A1, MAP4K2, LTB4R, NGB, ACOX1
10oxygen44 2411.5GSS, HSPA14, KCNJ5, AKR1A1, LTB4R, NGB
11haloperidol44 28 2 49 1114.5KCNJ5, AKR1A1, ADCYAP1
12charybdotoxin44 2811.5ADCYAP1, KCNJ5
13retinoic acid44 2411.5HSPA14, AKR1A1, LTB4R, ACOX1, ADH1A, ADCYAP1
14cysteine4410.4AKR1A1, NGB, CYGB, SERPINA6, SMPD1, GSS
15nadph44 2411.4ADH1A, SMPD1, ACOX1, AKR1A1
16serine4410.3HSPA14, AKR1A1, MAP4K2, SERPINA6, SMPD1, ADCYAP1
17phosphoinositide4410.3MAP4K2, LTB4R, SMPD1, ADCYAP1
18lutein4410.1ADCYAP1, LTB4R

GO Terms for genes affiliated with Anoxia

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Sources:
16Gene Ontology
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Biological processes related to Anoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:07005910.4TRIB3, CASP12
2oxygen transportGO:01567110.3CYGB, NGB
3response to oxidative stressGO:00697910.1GSS, CYGB, STK25

Molecular functions related to Anoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:00534410.4CYGB, NGB

Products for genes affiliated with Anoxia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anoxia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet