MCID: ANX004
MIFTS: 40

Anoxia malady

Summaries for Anoxia

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

MalaCards: Anoxia is related to hypoxia and cerebral hypoxia. An important gene associated with Anoxia is ACOX1 (acyl-CoA oxidase 1, palmitoyl), and among its related pathways is Metabolism. The compounds superoxide and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain.

Wikipedia:64 The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or \"low... more...

Aliases & Classifications for Anoxia

Sources:
44NINDS, 61UMLS
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Aliases & Descriptions:

anoxia 44 61


Related Diseases for Anoxia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Anoxia:



Diseases related to anoxia

Clinical Features for Anoxia

Drugs & Therapeutics for Anoxia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Anoxia

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Genetic Tests for Anoxia

Anatomical Context for Anoxia

Sources:
33MalaCards
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MalaCards organs/tissues related to Anoxia:

33
Bone marrow, Whole blood, Brain, Cortex, Cerebellum, Retina, Heart, Smooth muscle, Skeletal muscle, Colon, Liver, Breast, Skin, Testis, Monocytes, T cells, B cells, Endothelial, Fetal brain, Prefrontal cortex, Pons, Cardiac myocytes, Fetal liver, Pituitary, Testis germ

Animal Models for Anoxia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Anoxia

Sources:
51PubMed
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Articles related to Anoxia:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Regulation of p53 by reversible post-transcriptional and post-translational mechanisms in liver and skeletal muscle of an anoxia tolerant turtle, Trachemys scripta elegans. (23124036)
2013
2
Response of the Ubiquitous Pelagic Diatom Thalassiosira weissflogii to Darkness and Anoxia. (24312664)
2013
3
Mild therapeutic hypothermia and anoxia due to hanging: case series and review of the literature. (23923253)
2013
4
A new case of the absence of N20 at early cerebral anoxia-ischemia evaluation by somatosensory evoked potentials. (23339997)
2013
5
Hermit crabs and their symbionts: Reactions to artificially induced anoxia on a sublittoral sediment bottom. (22298914)
2012
6
Sex differences in the effects of perinatal anoxia on dopamine function in rats. (22061835)
2012
7
Early EEG correlates of neuronal injury after brain anoxia. (23128443)
2012
8
Late Devonian marine anoxia challenged by benthic cyanobacterial mats. (22882315)
2012
9
Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner. (22004513)
2012
10
Effects of polyphenol extract from olive pomace on anoxia-induced endothelial dysfunction. (22386654)
2012
11
Influence of light and anoxia on chemiosmotic energy conservation in Dinoroseobacter shibae. (21461053)
2011
12
Peach (Prunus persica) fruit response to anoxia: reversible ripening delay and biochemical changes. (21186173)
2011
13
Mechanisms of chloride in cardiomyocyte anoxia-reoxygenation injury: the involvement of oxidative stress and NF-kappaB activation. (21553261)
2011
14
Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDS. (21680874)
2011
15
Neuroprotective signaling pathways are modulated by adenosine in the anoxia tolerant turtle. (20648037)
2011
16
Serotonin prolongs survival of encapsulated pond snail embryos exposed to long-term anoxia. (20400638)
2010
17
Decreased temperature as a signal for regulation of heat shock protein expression in anoxic brain and heart: focus on "Expression of heat shock proteins in anoxic crucian carp (Carassius carassius): support for cold as a preparatory cue for anoxia". (20410473)
2010
18
The anti-angiogenic factor PEDF is present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts. (19298519)
2010
19
Epigenetics in anoxia tolerance: a role for histone deacetylases. (20437082)
2010
20
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. (18055514)
2008
21
Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4. (18408768)
2008
22
Epithelial to mesenchymal transformation in tubular epithelial cells undergoing anoxia. (18929865)
2008
23
The L-Type Ca+ and KATP channels may contribute to pacing-induced protection against anoxia-reoxygenation in the embryonic heart model. (18554212)
2008
24
Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes. (17191134)
2007
25
The unfolded protein response and integrated stress response to anoxia. (17473181)
2007
26
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. (16847457)
2007
27
Mouse model of diffuse brain damage following anoxia, evaluated by a new assay of generalized arousal. (17448465)
2007
28
Wheat genotypes show contrasting abilities to recover from anoxia in spite of similar anoxic carbohydrate metabolism. (17349715)
2007
29
Beyond anoxia: the physiology of metabolic downregulation and recovery in the anoxia-tolerant turtle. (17049896)
2007
30
Effects of anoxia and hypoxia on amyloid precursor protein processing in cerebral microvascular smooth muscle cells. (16783171)
2006
31
Spatiotemporal distribution of spectrin breakdown products induced by anoxia in adult rat optic nerve in vitro. (16163297)
2006
32
Metabolic-state-dependent remodeling of the transcriptome in response to anoxia and subsequent reoxygenation in Saccharomyces cerevisiae. (16963631)
2006
33
Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution. (15611069)
2005
34
Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia. (15642371)
2005
35
HIF-1alpha involvement in low temperature and anoxia survival by a freeze tolerant insect. (16311910)
2005
36
Effects of anoxia on serum immunoglobulin and albumin leakage through blood-brain barrier in mouse cerebellum as revealed by cryotechniques. (15325116)
2004
37
Anoxia tolerant brains. (15129179)
2004
38
Regulation of heme oxygenase-1 gene expression by anoxia and reoxygenation in primary rat hepatocyte cultures. (12709591)
2003
39
Anoxia tolerance in rice seedlings: exogenous glucose improves growth of an anoxia-'intolerant', but not of a 'tolerant' genotype. (14504303)
2003
40
Chemical anoxia delays germ cell apoptosis in the human testis. (12700196)
2003
41
A1 adenosine receptor overexpression decreases stunning from anoxia-reoxygenation: role of the mitochondrial K(ATP) channel. (12061393)
2002
42
L-arginine protects human heart cells from low-volume anoxia and reoxygenation. (11834473)
2002
43
In vivo measurement of superoxide in the cerebral cortex during anoxia-reoxygenation and ischemia-reperfusion. (12528925)
2002
44
Protective effects of preconditioning in cultured rat endothelial cells: effects on neutrophil adhesion and expression of ICAM-1 after anoxia and reoxygenation. (10430769)
1999
45
Neuroprotection by peptide growth factors against anoxia and nitric oxide toxicity requires modulation of protein kinase C. (7714002)
1995
46
Anoxia-reoxygenation-induced, neutrophil-mediated endothelial cell injury: role of elastase. (2396697)
1990
47
Periventricular leukomalacia related to neonatal anoxia: recognition by computed tomography. (318108)
1978
48
A pathological model for cerebral changes incident to paranatal anoxia. Report of a case of cerebral atrophy secondary to cardiorespiratory failure in infancy. (6067241)
1967
49
Renal impairment, hypertension and encephalomalacia in an infant surviving severe intra-uterine anoxia. (13120838)
1953
50
Anoxia as a cause of endocardial fibroelastosis in infancy. (14952103)
1952

Genetic Variations for Anoxia

Expression for genes affiliated with Anoxia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anoxia

Search GEO for disease gene expression data for Anoxia.

Pathways for genes affiliated with Anoxia

Sources:
54Reactome, 30KEGG
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Pathways related to Anoxia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4GSS, ADH1A, SMPD1, ACOX1, GPC4

Compounds for genes affiliated with Anoxia

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 2BitterDB, 50PharmGKB
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Compounds related to Anoxia according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1superoxide45 2411.6KCNJ5, AKR1A1, LTB4R, NGB, ACOX1, SMPD1
2fatty acid4510.6LTB4R, ACOX1, SERPINA6, ADCYAP1, GSS
3histidine4510.6NGB, CYGB, ACOX1, ADCYAP1
4h2o24510.6AKR1A1, NGB, CYGB, ACOX1, SMPD1, ADCYAP1
5atp45 2911.6HSPA14, KCNJ5, LTB4R, SLC8A2, ACOX1, SMPD1
6nitric oxide45 11 2412.5HSPA14, KCNJ5, LTB4R, NGB, CYGB, SMPD1
7glucose4510.5HSPA14, KCNJ5, TRIB3, MAP4K2, NGB, SERPINA6
8adp45 29 2412.5KCNJ5, STK25, MAP4K2, LTB4R, SMPD1, GSS
9lipid4510.5KCNJ5, AKR1A1, MAP4K2, LTB4R, NGB, ACOX1
10oxygen45 2411.5GSS, HSPA14, KCNJ5, AKR1A1, LTB4R, NGB
11haloperidol45 29 2 50 1114.5KCNJ5, AKR1A1, ADCYAP1
12charybdotoxin45 2911.5ADCYAP1, KCNJ5
13retinoic acid45 2411.5HSPA14, AKR1A1, LTB4R, ACOX1, ADH1A, ADCYAP1
14cysteine4510.4AKR1A1, NGB, CYGB, SERPINA6, SMPD1, GSS
15nadph45 2411.4ADH1A, SMPD1, ACOX1, AKR1A1
16serine4510.3HSPA14, AKR1A1, MAP4K2, SERPINA6, SMPD1, ADCYAP1
17phosphoinositide4510.3MAP4K2, LTB4R, SMPD1, ADCYAP1
18lutein4510.1ADCYAP1, LTB4R

GO Terms for genes affiliated with Anoxia

Sources:
16Gene Ontology
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Biological processes related to Anoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:07005910.4TRIB3, CASP12
2oxygen transportGO:01567110.3CYGB, NGB
3response to oxidative stressGO:00697910.1GSS, CYGB, STK25

Molecular functions related to Anoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:00534410.4CYGB, NGB

Products for genes affiliated with Anoxia

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Sources for Anoxia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet