MCID: ANX004
MIFTS: 36

Anoxia malady

Summaries for Anoxia

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Sources:
45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.

MalaCards: Anoxia is related to hypoglycemia and neuronitis. An important gene associated with Anoxia is TRIB3 (tribbles pseudokinase 3), and among its related pathways is Metabolism. The compounds dhea and l-glutamic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and endothelial.

Wikipedia:66 The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or \"low... more...

Aliases & Classifications for Anoxia

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45NINDS, 63UMLS
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Aliases & Descriptions:

anoxia 45 63


Related Diseases for Anoxia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Anoxia:



Diseases related to anoxia

Symptoms for Anoxia

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Drugs & Therapeutics for Anoxia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Anoxia

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Genetic Tests for Anoxia

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Anatomical Context for Anoxia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Anoxia:

34
Brain, Heart, Endothelial, Cortex, Liver, Smooth muscle, Skeletal muscle, Cardiac myocytes, Colon, Retina, Cerebellum, Prefrontal cortex, Skin, Pituitary, Testis, Breast, Bone marrow, Bone, Pons

Animal Models for Anoxia or affiliated genes

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Publications for Anoxia

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53PubMed
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Articles related to Anoxia:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Cytosolic calcium regulation in rat afferent vagal neurons during anoxia. (24189167)
2013
2
Silencing of angiotensina89converting enzyme by RNA interference prevents H9c2 cardiomyocytes from apoptosis induced by anoxia/reoxygenation through regulation of the intracellular renin-angiotensin system. (24126381)
2013
3
Nitric oxide metabolites during anoxia and reoxygenation in the anoxia-tolerant vertebrate, Trachemys scripta. (24143029)
2013
4
Hermit crabs and their symbionts: Reactions to artificially induced anoxia on a sublittoral sediment bottom. (22298914)
2012
5
Sex differences in the effects of perinatal anoxia on dopamine function in rats. (22061835)
2012
6
Effects of I^a88-agonists on force during and following anoxia in rat extensor digitorum longus muscle. (22492937)
2012
7
The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder. (22743170)
2012
8
Cell cycle arrest associated with anoxia-induced quiescence, anoxic preconditioning, and embryonic diapause in embryos of the annual killifish Austrofundulus limnaeus. (22570106)
2012
9
H2S protects hippocampal neurons from anoxia-reoxygenation through cAMP-mediated PI3K/Akt/p70S6K cell-survival signaling pathways. (20967511)
2011
10
Extract of Paris polyphylla Simth protects cardiomyocytes from anoxia-reoxia injury through inhibition of calcium overload. (21509672)
2011
11
Anoxia leads to a rapid translocation of human trypsinogen 4 to the plasma membrane of cultured astrocytes. (20345763)
2010
12
Serotonin prolongs survival of encapsulated pond snail embryos exposed to long-term anoxia. (20400638)
2010
13
Cholesterol depletion inhibits electrophysiological changes induced by anoxia in CA1 region of rat hippocampal slices. (19699721)
2009
14
Living without Oxygen: Anoxia-Responsive Gene Expression and Regulation. (19794879)
2009
15
A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell. (19262472)
2009
16
Differential response of antioxidant systems in leaves and roots of barley subjected to anoxia and post-anoxia. (19162369)
2009
17
Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries. (19412543)
2009
18
Acute anoxia stimulates proliferation in adult neural stem cells from the rat brain. (18330547)
2008
19
Anoxia-induced suspended animation in budding yeast as an experimental paradigm for studying oxygen-regulated gene expression. (18708563)
2008
20
Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway. (18439994)
2008
21
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. (18055514)
2008
22
Modulation of the c-Jun N-terminal kinase activity in the embryonic heart in response to anoxia-reoxygenation: involvement of the Ca2+ and mitoKATP channels. (18418700)
2008
23
Subfossil 16S rRNA gene sequences of green sulfur bacteria in the Black Sea and their implications for past photic zone anoxia. (18039829)
2008
24
Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions. (17532579)
2007
25
A citrus abscission agent induces anoxia- and senescence-related gene expression in Arabidopsis. (17556766)
2007
26
Anoxia-induced changes in pyridine nucleotide redox state in cortical neurons and astrocytes. (17191134)
2007
27
Intralipid minimizes hepatocytes injury after anoxia-reoxygenation in an ex vivo rat liver model. (17084595)
2007
28
Glutamate receptor changes associated with transient anoxia/hypoglycaemia in hippocampal slice cultures. (16519662)
2006
29
Analysis of signal transduction pathways during anoxia exposure in a marine snail: a role for p38 MAP kinase and downstream signaling cascades. (16326124)
2006
30
Nitrite reduces cytoplasmic acidosis under anoxia. (17071644)
2006
31
Adaptive responses of vertebrate neurons to anoxia--matching supply to demand. (16621734)
2006
32
Perinatal anoxia degrades auditory system function in rats. (16365292)
2005
33
Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. (15992372)
2005
34
Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. (15590660)
2005
35
Manipulation of ethanol production in anoxic rice coleoptiles by exogenous glucose determines rates of ion fluxes and provides estimates of energy requirements for cell maintenance during anoxia. (16061509)
2005
36
Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution. (15611069)
2005
37
Particulate arsenic and iron during anoxia in a eutrophic, urban lake. (15230312)
2004
38
Effects of triflusal on oxidative stress, prostaglandin production and nitric oxide pathway in a model of anoxia-reoxygenation in rat brain slices. (15157801)
2004
39
Sodium influx pathways during and after anoxia in rat hippocampal neurons. (15590922)
2004
40
Effects of anoxia on root ultrastructure of four neotropical trees. (15726814)
2004
41
Salvia miltiorrhiza attenuates the changes in contraction and intracellular calcium induced by anoxia and reoxygenation in rat cardiomyocytes. (12650853)
2003
42
Early cell evolution, eukaryotes, anoxia, sulfide, oxygen, fungi first (?), and a tree of genomes revisited. (12880199)
2003
43
Tolerance of crop plants to oxygen deficiency stress: fermentative activity and photosynthetic capacity of entire seedlings under hypoxia and anoxia. (12675741)
2003
44
Intracellular pH response to anoxia in acutely dissociated adult rat hippocampal CA1 neurons. (11976362)
2002
45
Pyruvate improvement of cellular energetics, not simply generating ATP during anoxia. (12085017)
2002
46
Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans. (12006646)
2002
47
Effect of NADPH oxidase inhibition on E-selectin expression induced by concomitant anoxia/reoxygenation and TNF-alpha. (12572857)
2002
48
Biphasic modulation of protein kinase C and enhanced cell toxicity by amyloid beta peptide and anoxia in neuronal cultures. (11158247)
2001
49
Calcium and increase excitability promote tolerance against anoxia in hippocampal slices. (10375673)
1999
50
ATP-sensitive potassium channels counteract anoxia in neurones of the substantia nigra. (2065741)
1991

Variations for Anoxia

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Expression for genes affiliated with Anoxia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anoxia

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Pathways for genes affiliated with Anoxia

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51PathCards, 56Reactome, 31KEGG
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Pathways related to Anoxia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.3TRIB3, GSS, AASS, ACOX1, GPC4

Compounds for genes affiliated with Anoxia

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Anoxia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dhea469.2SERPINA6, ACOX1
2l-glutamic acid30 25 1211.1GSS, AASS
3superoxide46 2510.1GSS, ACOX1, KCNJ5
4sulfate46 2510.0GSS, SERPINA6
5glutamate468.9GSS, AASS, ACOX1, KCNJ5
6atp46 309.8ACOX1, KCNJ5, AASS, GSS
7fatty acid468.8SERPINA6, ACOX1, GSS
8adp46 30 2510.7KCNJ5, STK25, GSS, AASS

GO Terms for genes affiliated with Anoxia

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17Gene Ontology
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Biological processes related to Anoxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular lipid metabolic processGO:0442559.8TRIB3, ACOX1
2response to oxidative stressGO:0069799.0GSS, STK25
3small molecule metabolic processGO:0442818.2TRIB3, GSS, AASS, ACOX1, GPC4

Products for genes affiliated with Anoxia

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Sources for Anoxia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet