Anoxia malady

NINDS: Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.³¹

MalaCards: Anoxia is related to alcoholism and glioblastoma. An important gene associated with Anoxia is CYGB (cytoglobin), and among its related pathways are Oxidative Stress Pathway (Erythrocyte) and Pathway_PA165980337. The compounds nadph and egcg have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and heart, and related mouse phenotypes are respiratory system and craniofacial.

Wikipedia: The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or \"low...⁴⁴ more...

anoxia 31 43

Diseases related to anoxia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 719)

id	Related Disease	Score	Top Affiliating Genes
1	alcoholism	28.4	GSR, ALDH9A1, AKR1A1, CYCS, TSPO, GABBR1
2	glioblastoma	27.9	SETD2, PARP1, TP53, HIF1A, GFAP, THBS1
3	retinol binding protein	26.7	RBP4, NAGLU, XDH, AKR1A1, TNF, CYGB
4	breast cancer	25.0	MMP1, IL8, CCND1, TP53, TNF, PTGS2
5	vaginitis	22.7	SELE, SERPINA6, PARP1, MMP1, IL2, IL8
6	neuronitis	18.0	GCH1, SELE, SETD2, SERPINF1, PARP1, KCNJ5
7	ischemia	16.6	SELE, SETD2, SERPINF1, NAGLU, VCAM1, PARP1
8	hypoxia	16.5	SELE, SETD2, SERPINF1, VCAM1, PARP1, KCNJ5
9	cerebritis	16.1	RBP4, SELE, SETD2, NAGLU, VCAM1, PARP1
10	colon cancer	14.7	SELE, SETD2, VCAM1, PARP1, UGCG, XDH
11	melanoma	14.7	SELE, SETD2, SERPINF1, VCAM1, PARP1, UGCG
12	tyrosine-oxidase temporary deficiency	13.7	XDH, CAT, ACOX1
13	intestinal disease	13.6	XDH, HMOX1, C5AR1
14	diabetic cataract	13.5	SERPINF1, GSR, CAT, SOD1
15	chronic granulomatous disease	13.5	CAT, CYBB, TSPO, SOD1
16	alcoholic pancreatitis	13.5	ALDH9A1, AKR1A1, ELANE
17	mild pre-eclampsia	13.5	VCAM1, XDH, SOD1
18	retinal vascular disease	13.5	SERPINF1, DYT10, CTGF
19	diabetic angiopathy	13.5	SELE, NAGLU, CAT
20	drug dependence	13.5	NOS1, TSPO, SOD1, AASS, ADH1A
21	asphyxia neonatorum	13.4	NAGLU, XDH, CAT
22	hyperphenylalaninemia	13.4	GCH1, CAT, NOS1, SOD1
23	primary hyperoxaluria	13.4	GSR, CAT, AGT, EPO
24	proliferative vitreoretinopathy	13.4	FGF2, CTGF, GFAP, THBS1
25	spontaneous pneumothorax	13.4	CD36, ELANE, SOD1
26	hepatitis	13.4	RBP4, XDH, GSR, FAS, STAT1
27	congenital heart defect	13.4	SETD2, KCNJ5, GSR, AKR1A1, HMOX1, CYCS
28	thromboangiitis obliterans	13.4	SELE, VCAM1, ICAM1
29	stomach carcinoma	13.4	CDH1, FAS, CCND1, AKR1A1
30	alcohol abuse	13.4	GSR, GSS, ALDH9A1, CAT, AKR1A1, CYCS
31	acute t cell leukemia	13.4	PARP1, FAS, CASP3, CYCS
32	neurocirculatory asthenia	13.3	MMP1, GSR, CAT, AGT, SOD1
33	hereditary pancreatitis	13.3	CD36, ALDH9A1, AKR1A1, ELANE, SOD1, GDF15
34	alcoholic liver cirrhosis	13.3	IL8, ALDH9A1, CAT, AKR1A1, SOD1
35	corneal neovascularization	13.3	SERPINF1, CD36, FGF2, THBS1
36	endolymphatic sac tumor	13.3	SETD2, HIF1A, EPO
37	krabbe disease	13.3	CASP3, PLA2G4A, NOS2, PRKAB1
38	hemorrhagic shock and encephalopathy syndrome	13.3	XDH, HMOX1, NOS2
39	acute chest syndrome	13.3	VCAM1, IL8, CYGB, NOS1
40	senile cataract	13.3	SERPINF1, GSR, FGF2, CAT, SOD1
41	oral lichen planus	13.3	VCAM1, MMP1, ICAM1, CASP3
42	arterial occlusive disease	13.3	SELE, VCAM1, GSR, ICAM1, TSPO
43	peripheral arterial occlusive disease	13.3	SELE, VCAM1, GSR, ICAM1
44	mesenchymal cell neoplasm	13.3	CCND1, CASP3, GFAP
45	endemic goiter	13.2	RBP4, GSR, FGF2, CAT, SOD1
46	pick's disease	13.2	UGCG, CASP3, HMOX1, DYT10, SMPD1, TSPO
47	chronic ulcer of skin	13.2	CD36, MMP1, FGF2, ELANE
48	idiopathic interstitial pneumonia	13.2	IL8, ICAM1, CTGF, ELANE, THBS1
49	epilepsy syndrome	13.2	KCNJ5, GSR, HMOX1, NOS1, GFAP, TSPO
50	brain edema	13.2	PARP1, CAT, HMOX1, GFAP, TSPO, SOD1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to anoxia:

²²

MGI Mouse Phenotypes related to anoxia:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	ADORA1, LTB4R, NOS1, PLA2G4A, SMPD1
2	craniofacial phenotype	MP:0005382	10.0	NAGLU, ATF4, SLC8A1, ELAVL1, AKR1A1, MARCKS
3	endocrine/exocrine gland phenotype	MP:0005379	9.9	XDH, ATF3, OXTR, IL2
4	embryogenesis phenotype	MP:0005380	9.7	SETD2, MARCKS, ADCYAP1, SLC8A1, CYCS, ELAVL1
5	hematopoietic system phenotype	MP:0005397	9.3	FGF2, MAD2L1, CCND1, GPC4, AKR1A1, CYCS
6	renal/urinary system phenotype	MP:0005367	9.3	SERPINA6, ADORA1, THBS1, HIF1A, PLA2G4A, CYBB
7	integument phenotype	MP:0010771	9.2	OXTR, ADORA1, GABBR1, PARP1, CCND1, ATF4
8	other phenotype	MP:0005395	8.6	NOS2, NOS1, PLA2G4A, PTGS2, MARCKS, IL2
9	liver/biliary system phenotype	MP:0005370	8.1	CD36, IL2, TP53, CYGB, SMPD1, ACOX1
10	digestive/alimentary phenotype	MP:0005381	8.0	HIF1A, ELAVL1, GFAP, NOS2, NOS1, PLA2G4A
11	normal phenotype	MP:0002873	7.8	ELAVL1, TRIB3, RBP4, ELANE, STAT1, OXTR
12	nervous system phenotype	MP:0003631	7.7	CCND1, MARCKS, CD36, PARP1, UGCG, CASP12
13	no phenotypic analysis	MP:0003012	7.6	MAP4K2, OXTR, SERPINA6, VCAM1, PARP1, UGCG
14	behavior/neurological phenotype	MP:0005386	7.2	NAGLU, UGCG, JUN, IL2, FAS, MARCKS
15	adipose tissue phenotype	MP:0005375	6.9	PTGS2, CD36, XDH, TP53, TNF, PPARG
16	reproductive system phenotype	MP:0005389	6.7	RBP4, SERPINF1, AGT, THBS1, STAT3, OXTR
17	immune system phenotype	MP:0005387	6.6	MAD2L1, GFAP, THBS1, STAT3, STAT1, PRKAB1
18	skeleton phenotype	MP:0005390	6.3	NOS1, PPARG, CTGF, CYCS, PTGS2, TP53
19	mortality/aging	MP:0010768	5.8	GSS, NOS2, ELANE, ELAVL1, AGT, GFAP
20	muscle phenotype	MP:0005369	5.1	ADCYAP1, HMOX1, PLA2G4A, OXTR, CYBB, PTGS2
21	growth/size phenotype	MP:0005378	5.1	AGT, GFAP, THBS1, STAT3, STAT1, OXTR
22	tumorigenesis	MP:0002006	4.8	CDH1, FGF2, IL2, FAS, MAD2L1, CCND1
23	vision/eye phenotype	MP:0005391	4.6	CASP3, SOD1, PRKAB1, STAT1, TP53, TNF
24	cardiovascular system phenotype	MP:0005385	1.8	CCND1, FAS, IL2, FGF2, GSR, CDH1
25	cellular phenotype	MP:0005384	1.7	RBP4, SELE, NAGLU, VCAM1, PARP1, CIRBP
26	homeostasis/metabolism phenotype	MP:0005376	0.9	FAS, CYGB, CTGF, SMPD1, PLA2G4A, NOS1

Articles related to anoxia:

(show top 50)    (show all 77)

id	Title	Authors	Year	Affiliating Genes
1	The anti-angiogenic factor PEDF is present in the hum an heart and is regulated by anoxia in cardiac myocytes and fibroblasts. (19298519)	Rychli K.... Wojta J.	2010	SERPINF1
2	A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell. (19262472)	Nagata D.... Hirata Y.	2009	PRKAB1
3	Differential response of antioxidant systems in leaves and roots of barley subjected to anoxia and post-anoxia. (19162369)	Skutnik M.... Rychter A.M.	2009	ACOX1
4	Phosphoglycerate kinase 1 expression responds to freezing, anoxia, and dehydration stresses in the freeze tolerant wood frog, Rana sylvatica. (18785212)	Wu S.... Storey K.B.	2009	PGK1
5	Anoxia-induced NF-kappaB-dependent upregulation of NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons. (19164785)	Sirabella R.... Annunziato L.	2009	SLC8A1, SLC8A2, SLC8A3
6	SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. (18364353)	Nogueira E.... Pombo C.M.	2008	MAP4K2, STK25
7	Heat acclimation and cross-tolerance against anoxia i n Arabidopsis. (18410489)	Banti V.... Perata P.	2008	AKR1A1
8	Death-resistant and nonresistant malignant human cell lines under anoxia in vitro. (18071865)	Yasuda M.... Yasuda Y.	2007	EPO
9	Protective effects of sasanquasaponin on injury of en dothelial cells induced by anoxia and reoxygenation in vitro. (17910612)	Huang Q.... Dai Y.	2007	SOD1
10	Antioxidant defenses preserve membrane transport activity in Chironomus riparius larvae exposed to anoxia. (17630655)	Forcella M.... Parenti P.	2007	GSS
11	Involvement of MAPK/ERK kinase-ERK pathway in exogenous bFGF-induced Egr-1 binding activity enhancement in anoxia-reoxygenation injured astrocytes. (17687397)	Liu Y.... Ye Z.R.	2007	FGF2
12	Effects of ischemia and anoxia on cell activation and cell cycle of cultured astrocytes in vitro. (16710998)	Luo X.... Wang W.	2006	GFAP
13	Protein synthesis by rice coleoptiles during prolonged anoxia: implications for glycolysis, growth and energy utilization. (16027131)	Huang S.... Millar A.H.	2005	CIRBP
14	The relationship between TNF-alpha and the injury of renal tubular cells caused by anoxia/reoxygenation (16256027)	Dong W.B.... Deng C.L.	2005	TNF
15	Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia. (15642371)	Schnitzer S.E.... BrA1ne B.	2005	HIF1A
16	Anoxia-reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts: modulation by the PPAR-gamma ligand pioglitazone. (15550788)	Chen K.... Mehta J.L.	2004	PPARG, MMP1, CD36
17	Anoxia/reoxygenation down-regulates the expression of E-cadherin in human colon cancer cell lines. (15194219)	Kokura S.... Yoshikawa T.	2004	CDH1
18	Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. (12586734)	Zhao H.... Stahl G.L.	2003	SMPD1, UGCG
19	Genetic and biochemical analysis of anaerobically-induced enzymes during seed germination of Echinochloa crus-galli varieties tolerant and intolerant of anoxia. (12709489)	Fukao T.... Rumpho M.E.	2003	AKR1A1, ALDH9A1
20	Influence of anoxia/reoxygenation on immunofunction of endothelial cells and effect of intervention with yisheng injection on it (12872402)	Jiang H.M.... Li Y.P.	2003	IL2
21	Effect of NADPH oxidase inhibition on E-selectin expression induced by concomitant anoxia/reoxygenation and TNF-alpha. (12572857)	Paysant J.R.... Verbeuren T.J.	2002	ICAM1, TNF, SELE
22	Netilmicin effect on urinary retinol binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG) in preterm newborns with and without anoxia. (11892904)	Cataldi L.... Fanos V.	2002	RBP4, NAGLU
23	Anoxia-induced changes in purine nucleoside metabolism of in vitro aged human fibroblasts. (11883713)	Reisert P.S.... Fenton R.A.	2002	XDH
24	Oxygen consumption and electron spin resonance studie s of free radical production by alveolar cells exposed to anoxia: inhibiting ef fects of the antibiotic ceftazidime. (12189054)	Mouithys-Mickalad A.... Deby-Dupont G.	2002	SOD1
25	Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1. (12082608)	Albertoni M.... Hegi M.E.	2002	TP53, GDF15
26	Regulation of a rat VL30 element in human breast cancer cells in hypoxia and anoxia: role of HIF-1. (12402159)	Ameri K.... Harris A.L.	2002	SETD2
27	A study on the protective mechanism of yisheng injec tion against the anoxia-reoxygenation injury to endothelial cells (12575189)	Li S.... Cheng J.	2002	AASS
28	Pituitary adenylate cyclase activating polypeptide is highly abundant in the nervous system of anoxia-tolerant turtle, Pseudemys scripta elegans. (11390016)	ReglAPdi D.... Arimura A.	2001	ADCYAP1
29	Regulation of alcoholic fermentation in coleoptiles o f two rice cultivars differing in tolerance to anoxia. (10938871)	Gibbs J.... Greenway H.	2000	AKR1A1
30	Endothelial cells exposed to anoxia/reoxygenation are hyperadhesive to T-lymphocytes: kinetics and molecular mechanisms. (10708334)	Kokura S.... Aw T.Y.	2000	JUN
31	Anoxia pretreatment protects soybean cells against H( 2)O(2)-induced cell death: possible involvement of peroxidases and of alternati ve oxidase. (10908716)	Amora Y.... Levinea A.	2000	ACOX1
32	Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells. (10811871)	Tenan M.... Van Meir E.G.	2000	THBS1
33	Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. (10487833)	Kunz M.... Gillitzer R.	1999	IL8
34	Calcium and increase excitability promote tolerance against anoxia in hippocampal slices. (10375673)	PAcrez-PinzA^n M.A.... Centeno J.M.	1999	ADORA1
35	Elevation of apoptotic potential by anoxia hyperoxia shift in NIH3T3 cells. (10485334)	Chen Y.C.... Lin J.K.	1999	PARP1
36	Cytochrome C is released from mitochondria into the cytosol after cerebral anoxia or ischemia. (9886353)	PAcrez-PinzA^n M.A.... Sick T.J.	1999	CYCS
37	Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and the n reoxygenated. (9054746)	Leo R.... Violi F.	1997	PLA2G4A
38	Molecular characterization and promoter analysis of the maize cytosolic glyceraldehyde 3-phosphate dehydrogenase gene family and its expression during anoxia. (9037163)	Manjunath S.... Sachs M.M.	1997	GPC4, ADH1A
39	O2 availability modulates transmembrane Ca2+ flux via second-messenger pathways in anoxia-tolerant hepatocytes. (9074963)	Land S.C.... Smith P.J.	1997	DYT10
40	Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells. (9400372)	Ichikawa H.... Aw T.Y.	1997	XDH
41	Cellular mechanisms of protection by metabotropic glu tamate receptors during anoxia and nitric oxide toxicity. (8632165)	Maiese K.... TenBroeke M.	1996	DYT10
42	Neuroprotection by peptide growth factors against anoxia and nitric oxide toxicity requires modulation of protein kinase C. (7714002)	Maiese K.... Boccone L.	1995	DYT10
43	Endogenous GABA attenuates CNS white matter dysfunction following anoxia. (7823173)	Fern R.... Ransom B.R.	1995	GABBR1, DYT10
44	Effect of glutathione on endothelial prostacyclin syn thesis after anoxia. (8333500)	Hempel S.L.... Spector A.A.	1993	GSR
45	Unchanged [3H]MK-801 binding and increased [3H]flunit razepam binding in turtle forebrain during anoxia. (8275301)	Sakurai S.Y.... Albin R.L.	1993	TSPO
46	Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia. (8230323)	Maiese K.... Wagner J.A.	1993	DYT10
47	Neuronal selectivity of ATP-sensitive potassium channels in guinea-pig substantia nigra revealed by responses to anoxia. (1464828)	Murphy K.P.... Greenfield S.A.	1992	KCNJ5
48	Anoxia-hyperoxia induces monocyte-derived interleukin-8. (1522234)	Metinko A.P.... Strieter R.M.	1992	IL8, C5AR1
49	Measurement of free radical generation from endothel ial cells and observation of cell injury exposed to anoxia-reoxygenation (1318495)	Nishida K.	1992	SOD1, CAT
50	Anoxia-reoxygenation-induced, neutrophil-mediated endothelial cell injury: role of elastase. (2396697)	Inauen W.... Kvietys P.R.	1990	ELANE

Genes related to anoxia according to GeneCards:

(show top 50)    (show all 83)

id	Symbol	Description	Score	GeneCards Section Context
1	CYGB	cytoglobin	11.0	Publications
2	PMM1	phosphomannomutase 1	11.0	Functions
3	CIRBP	cold inducible RNA binding protein	11.0	Publications
4	NGB	neuroglobin	11.0	Publications
5	CASP12	caspase 12 (gene/pseudogene)	11.0	Pathways & Interactions
6	STK25	serine/threonine kinase 25	11.0	Publications
7	ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	11.0	Publications
8	ACOX1	acyl-CoA oxidase 1, palmitoyl	11.0	Publications
9	SLC8A2	solute carrier family 8 (sodium/calcium exchanger), member 2	11.0	Publications
10	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	11.0	Publications
11	TRIB3	tribbles homolog 3 (Drosophila)	11.0	Publications
12	MARCKS	myristoylated alanine-rich protein kinase C substrate	11.0	Publications
13	ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	11.0	Publications
14	GDF15	growth differentiation factor 15	11.0	Publications
15	GSS	glutathione synthetase	11.0	Publications
16	GPC4	glypican 4	11.0	Publications
17	HSPA14	heat shock 70kDa protein 14	11.0	Publications
18	MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	11.0	Orthologs
19	LTB4R	leukotriene B4 receptor	11.0	Publications
20	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
21	PGK1	phosphoglycerate kinase 1	11.0	Publications
22	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0	Publications
23	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
24	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	11.0	Publications
25	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	11.0	Publications
26	OXTR	oxytocin receptor	11.0	Pathways & Interactions
27	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	11.0	Publications
28	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
29	ATF3	activating transcription factor 3	11.0	Publications
30	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11.0	Publications
31	CYBB	cytochrome b-245, beta polypeptide	11.0	Publications
32	AASS	aminoadipate-semialdehyde synthase	11.0	Publications
33	ALDH9A1	aldehyde dehydrogenase 9 family, member A1	11.0	Publications
34	C5AR1	complement component 5a receptor 1	11.0	Publications
35	UGCG	UDP-glucose ceramide glucosyltransferase	11.0	Publications
36	SLC15A1	solute carrier family 15 (oligopeptide transporter), member 1	11.0	Publications
37	GCH1	GTP cyclohydrolase 1	11.0	Publications
38	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
39	TSPO	translocator protein (18kDa)	11.0	Publications
40	ADORA1	adenosine A1 receptor	11.0	Publications
41	RBP4	retinol binding protein 4, plasma	11.0	Publications
42	SLC8A3	solute carrier family 8 (sodium/calcium exchanger), member 3	11.0	Publications
43	CTGF	connective tissue growth factor	11.0	Pathways & Interactions
44	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	11.0	Publications
45	XDH	xanthine dehydrogenase	11.0	Publications
46	SETD2	SET domain containing 2	11.0	Publications
47	STAT1	signal transducer and activator of transcription 1, 91kDa	11.0	Publications
48	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	11.0	Publications
49	THBS1	thrombospondin 1	11.0	Publications
50	ADAM10	ADAM metallopeptidase domain 10	11.0	Publications

Pathways related to anoxia according to GeneDecks:

(show top 50)    (show all 69)

id	Pathway	Score	Top Affiliating Genes
1	Oxidative Stress Pathway (Erythrocyte)34	10.4	GSR, CAT, SOD1
2	Pathway_PA16598033734	10.4	GSR, CAT, SOD1
3	Oxidative Stress Pathway (Erythrocyte)34	10.4	SOD1, CAT, GSR
4	Immune response Oncostatin M signaling via JAK-Stat in human cells10	10.2	STAT3, CCND1
5	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.2	PLA2G4A, CYCS
6	iNOS Signaling36	10.2	ATF3, ATF4, STAT1, JUN, ELAVL1
7	Doxorubicin Pathway, Pharmacokinetics34	10.1	XDH, SOD1, CAT, NOS2, NOS1, AKR1A1
8	Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics34	10.0	NOS2, CYCS, NOS1, AKR1A1
9	Immune response_Oncostatin M signaling via JAK-Stat in human cells41	9.9	STAT1, STAT3, MMP1, CCND1
10	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.8	XDH, SOD1, TP53, CAT
11	Development_HGF signaling pathway41	9.6	JUN, CDH1, FAS, STAT3
12	UVA-Induced MAPK Signaling36	9.6	TP53, CYCS, STAT1, JUN, CASP3
13	Pathogenesis of ALS36	9.4	TP53, CASP3, SOD1, CYCS
14	p53 signaling pathway20	9.4	CYCS, FAS, TP53, THBS1, CCND1, CASP3
15	African trypanosomiasis20	9.4	SELE, ICAM1, FAS, VCAM1, TNF
16	TNFR1 Pathway36	9.3	MAP4K2, JUN, TNF, CYCS, CASP3
17	LDL Oxidation in Atherogenesis36	9.3	TNF, CD36, VCAM1, ICAM1, PLA2G4A, SMPD1
18	TNF Signaling36	9.3	JUN, ATF4, CYCS, TNF, CASP3, ATF3
19	Apoptosis and survival Caspase cascade10	9.3	TNF, PARP1, FAS, CASP3, CYCS
20	Apoptosis and survival_Caspase cascade41	9.3	CYCS, CASP3, FAS, TNF, PARP1
21	Ceramide Pathway36	9.3	ATF4, JUN, SMPD1, CYCS, ATF3, CASP3
22	Apoptosis and survival TNFR1 signaling pathway10	9.2	CYCS, TNF, CASP3, MAP4K2, JUN
23	Apoptosis and survival_Lymphotoxin-beta receptor signaling41	9.2	CYCS, IL8, IL2, JUN, CASP3, VCAM1
24	Apoptosis and survival_TNFR1 signaling pathway41	9.2	TNF, CASP3, MAP4K2, JUN, CYCS
25	Apoptosis and survival Lymphotoxin-beta receptor signaling10	9.2	VCAM1, JUN, IL2, IL8, CASP3, CYCS
26	HIF1Alpha Pathway36	9.1	JUN, ATF4, TP53, HIF1A, EPO
27	Bladder cancer20	9.1	THBS1, TP53, CCND1, MMP1, IL8, CDH1
28	Signal transduction_JNK pathway41	9.1	TNF, TP53, MAP4K2, FAS, JUN
29	Signal transduction JNK pathway10	9.0	FAS, JUN, TNF, TP53, MAP4K2
30	Metabolic pathways20	9.0	XDH, UGCG, GCH1, SMPD1, NAGLU, GSS
31	Malaria20	8.9	CD36, ICAM1, TNF, VCAM1, SELE, THBS1
32	Toxoplasmosis20	8.9	CYCS, TNF, CASP3, PLA2G4A, STAT3, STAT1
33	ILK Signaling36	8.9	ATF4, HIF1A, JUN, CDH1, FGF2, PTGS2
34	Amyotrophic lateral sclerosis (ALS)20	8.6	CASP3, TP53, CAT, CYCS, NOS1, SOD1
35	Influenza A20	8.6	JUN, IL8, FAS, ICAM1, TNF, CYCS
36	Immune response IL-1 signaling pathway10	8.5	IL8, STAT1, NOS2, PTGS2, TNF, HMOX1
37	Immune response_IL-1 signaling pathway41	8.5	JUN, HMOX1, TNF, PTGS2, NOS2, IL8
38	Renin-Angiotensin Pathway36	8.4	JUN, PTGS2, VCAM1, AGT, CTGF, STAT1
39	Mitochondrial Apoptosis36	8.4	IL2, CASP3, CASP12, CTGF, CYCS, FGF2
40	MAPK signaling pathway20	8.3	FGF2, JUN, ATF4, MAP4K2, CASP3, TP53
41	Chagas disease (American trypanosomiasis)20	8.3	FAS, JUN, NOS2, IL8, IL2, TNF
42	Immune response MIF in innate immunity response10	8.3	JUN, NOS2, PTGS2, TNF, TP53, IL8
43	Immune response_MIF in innate immunity response41	8.3	IL8, TP53, TNF, PTGS2, NOS2, JUN
44	Apoptosis Signaling Pathways37	8.3	CASP3, TP53, TNF, CYCS, FAS
45	Pancreatic Adenocarcinoma36	7.9	CTGF, CCND1, STAT1, STAT3, PTGS2, TP53
46	Immune response_MIF-mediated glucocorticoid regulation41	7.7	NOS2, JUN, MMP1, IL2, IL8, ICAM1
47	Immune response MIF-mediated glucocorticoid regulation10	7.7	PTGS2, NOS2, TNF, ICAM1, IL8, IL2
48	Pathways in cancer20	7.5	CYCS, CASP3, FGF2, MMP1, CDH1, TP53
49	Colorectal Cancer Metastasis36	7.5	MMP1, CDH1, CASP3, TNF, STAT3, TP53
50	Molecular Mechanisms of Cancer36	7.4	HIF1A, FGF2, IL2, CCND1, CASP3, CDH1

Compounds related to anoxia according to GeneDecks:

(show top 50)    (show all 449)

id	Compound	Score	Top Affiliating Genes
1	nadph32 18	11.2	HIF1A, ACOX1, SMPD1, CYCS, GCH1, AASS
2	egcg32	10.1	SOD1, PRKAB1, STAT1, ELANE, CYCS, CAT
3	glucose32	9.8	SLC15A1, ELAVL1, NGB, CTGF, CYBB, HSPA14
4	ascorbic acid32 18	10.5	EPO, PGK1, ACOX1, NOS1, FAS, GSS
5	sp 60012532 42	10.5	MMP1, VCAM1, CASP3, TP53, CYCS, CTGF
6	apocynin32	9.3	SELE, SETD2, VCAM1, NOS2, CYBB, DYT10
7	peroxynitrite32	9.2	SLC8A1, SOD1, STAT1, GFAP, NGB, NOS2
8	rotenone32	9.0	PARP1, KCNJ5, SOD1, TSPO, HIF1A, CYCS
9	rottlerin32 42	9.9	ELANE, PLA2G4A, DYT10, HMOX1, CCND1, IL8
10	rapamycin32 42	9.9	CTGF, MAP4K2, IL2, ATF4, KCNJ5, PLA2G4A
11	c2ceramide32	8.9	PLA2G4A, CYCS, DYT10, TNF, CASP3, JUN
12	arginine32	8.8	AKR1A1, GSR, ATF4, XDH, SERPINA6, GCH1
13	s-nitroso-n-acetylpenicillamine32	8.6	XDH, PARP1, IL8, CASP3, CAT, SOD1
14	gsno32	8.6	SETD2, XDH, SOD1, HIF1A, NOS2, NOS1
15	ns 39832 42	9.5	NOS2, PLA2G4A, TNF, HMOX1, IL8, FGF2
16	silymarin32	8.5	PTGS2, CAT, CCND1, GSR, JUN, XDH
17	8-isoprostane32	8.5	SOD1, PLA2G4A, CYBB, TNF, HMOX1, CAT
18	h2o232	8.4	ADCYAP1, C5AR1, PGK1, ALDH9A1, ICAM1, ATF3
19	parthenolide32	8.4	STAT3, NOS2, CYCS, PTGS2, TP53, CASP3
20	atp32	8.3	ADCYAP1, ADORA1, C5AR1, AASS, PGK1, SLC8A2
21	phosphatidylinositol32	7.9	DYT10, CASP3, ICAM1, CCND1, MARCKS, FAS
22	histamine32 18	8.8	GABBR1, ADCYAP1, ADORA1, C5AR1, TSPO, HIF1A
23	alanine32	7.8	LTB4R, PLA2G4A, HMOX1, AKR1A1, ALDH9A1, MARCKS
24	pge232	7.6	C5AR1, OXTR, STAT1, AGT, HIF1A, NOS1
25	nitric oxide32 9 18 9	10.3	ELAVL1, NAGLU, SERPINF1, SELE, GCH1, VCAM1
26	rosiglitazone32 9 18 9	10.3	VCAM1, SELE, RBP4, JUN, CD36, MMP1
27	diphenyleneiodonium32	7.3	SOD1, AGT, HIF1A, NOS2, CYCS, CYBB
28	paclitaxel32 34 9 9	10.2	PGK1, PARP1, SETD2, UGCG, ATF3, CDH1
29	testosterone32 9 18 9	10.2	EPO, ADCYAP1, PGK1, OXTR, VCAM1, SERPINA6
30	cyclosporin a32 42	8.1	ICAM1, IL8, IL2, FGF2, MMP1, JUN
31	arsenite32 18	8.1	CCND1, FAS, GSS, GSR, MMP1, JUN
32	ciglitazone32	7.1	STAT1, STAT3, NOS2, PPARG, PTGS2, TNF
33	cysteine32	7.0	GABBR1, C5AR1, SLC15A1, SLC8A1, STAT1, THBS1
34	prostacyclin32	7.0	C5AR1, SELE, VCAM1, FGF2, SOD1, THBS1
35	doxorubicin32 34 9 9	10.0	STAT1, STAT3, THBS1, HIF1A, SMPD1, SELE
36	lipid32	6.8	C5AR1, SLC15A1, SLC8A1, SOD1, PRKAB1, OXTR
37	resveratrol32 9 18 9	9.6	PARP1, NOS2, NOS1, PPARG, CYCS, PTGS2
38	oxygen32 18	7.5	ADCYAP1, C5AR1, PRKAB1, STAT1, THBS1, GFAP
39	troglitazone32 42 9 9	9.5	PRKAB1, PPARG, PTGS2, TNF, CASP3, ICAM1
40	15-deoxy-delta-12,14-prostaglandin j232	6.3	CTGF, CYCS, PTGS2, TNF, HMOX1, CASP3
41	superoxide32 18	7.2	C5AR1, PGK1, SOD1, PRKAB1, STAT1, AKR1A1
42	indomethacin32 9 9	8.0	STAT1, TSPO, AGT, NOS2, NOS1, PLA2G4A
43	lactate32	5.6	EPO, PGK1, SLC8A1, SOD1, PRKAB1, GFAP
44	ly29400232	5.5	PRKAB1, STAT1, STAT3, THBS1, AGT, NOS2
45	curcumin32	5.2	NOS2, PARP1, VCAM1, JUN, CDH1, MMP1
46	retinoic acid32 42 18	6.9	PPARG, JUN, ATF3, UGCG, PARP1, VCAM1
47	pdtc32	4.7	PTGS2, DYT10, TNF, TP53, HMOX1, CAT
48	pd 98,05932	4.6	GDF15, ADCYAP1, C5AR1, STAT1, STAT3, THBS1
49	dexamethasone32 42 34 9 9	7.6	ADCYAP1, ADORA1, OXTR, STAT1, STAT3, THBS1
50	genistein32 9 18 9	6.1	VCAM1, SETD2, SELE, PARP1, CASP3, ALDH9A1

Cellular components related to anoxia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	dendritic spine	GO:043197	10.0	SLC8A2, SLC8A3, SLC8A1, NOS1, GABBR1
2	neuronal cell body	GO:043025	9.7	CYGB, SOD1, SLC8A3, SLC8A2, ADORA1, GABBR1
3	external side of plasma membrane	GO:009897	8.8	THBS1, TNF, VCAM1, KCNJ5, CD36, FAS
4	nucleoplasm	GO:005654	7.6	CASP3, STAT3, HIF1A, ELAVL1, PPARG, STAT1
5	extracellular space	GO:005615	6.7	AGT, CTGF, SMPD1, THBS1, SOD1, EPO
6	plasma membrane	GO:005886	6.3	CTGF, LTB4R, STAT3, OXTR, SOD1, GABBR1
7	cytosol	GO:005829	5.8	ADH1A, TRIB3, HMOX1, AKR1A1, CAT, CASP3

Biological processes related to anoxia according to GeneDecks:

(show all 35)

id	Name	GO ID	Score	Top Affiliating Genes
1	telencephalon development	GO:021537	10.6	SLC8A3, SLC8A1, OXTR, SLC8A2
2	calcium ion transport into cytosol	GO:060402	10.3	SLC8A1, SLC8A3, SLC8A2
3	response to tumor necrosis factor	GO:034612	10.1	SELE, ADAM10, CASP3, GCH1
4	response to hydrogen peroxide	GO:042542	10.0	JUN, HMOX1, PLA2G4A, SOD1, SLC8A1
5	response to ethanol	GO:045471	9.8	STAT3, SOD1, RBP4, CCND1, ICAM1, GABBR1
6	positive regulation of necrotic cell death	GO:010940	9.8	TNF, FAS, TSPO
7	cellular response to lipopolysaccharide	GO:071222	9.7	ICAM1, IL8, CD36, TSPO, NOS2
8	nitric oxide biosynthetic process	GO:006809	9.7	GCH1, NOS1, NOS2
9	lactation	GO:007595	9.7	XDH, OXTR, HIF1A, CCND1
10	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.7	XDH, CD36, AGT, TP53, TSPO, THBS1
11	aging	GO:007568	9.6	EPO, TSPO, AGT, PLA2G4A, FAS, JUN
12	leukocyte tethering or rolling	GO:050901	9.5	TNF, SELE, VCAM1
13	regulation of blood pressure	GO:008217	9.4	GCH1, SOD1, PPARG, PTGS2, HMOX1
14	response to estrogen stimulus	GO:043627	9.4	EPO, PPARG, HMOX1, CCND1, FAS
15	negative regulation of neuron apoptotic process	GO:043524	9.3	JUN, HMOX1, HIF1A, AGT, SOD1
16	positive regulation of fever generation	GO:031622	9.3	PLA2G4A, TNF, PTGS2
17	response to organic cyclic compound	GO:014070	9.2	CTGF, PTGS2, ICAM1, CCND1, JUN, STAT3
18	response to lipopolysaccharide	GO:032496	9.1	FAS, PTGS2, GCH1, EPO, PLA2G4A, JUN
19	response to salt stress	GO:009651	9.0	EPO, AGT, TNF, TP53
20	activation of MAPK activity	GO:000187	9.0	FGF2, C5AR1, SOD1, THBS1, TNF
21	response to glucocorticoid stimulus	GO:051384	8.9	PLA2G4A, PTGS2, TNF, FAS, SERPINF1
22	blood coagulation	GO:007596	8.9	MMP1, TP53, NOS1, THBS1, PLA2G4A, SOD1
23	induction of apoptosis	GO:006917	8.7	THBS1, AGT, PPARG, TNF, CASP3, FAS
24	cellular response to hypoxia	GO:071456	8.7	TP53, HIF1A, EPO, PTGS2, HMOX1, ICAM1
25	response to hypoxia	GO:001666	8.6	SLC8A1, THBS1, ADORA1, HIF1A, NOS1, TNF
26	positive regulation of smooth muscle cell proliferation	GO:048661	8.5	HIF1A, PTGS2, STAT1, ELANE, TNF, HMOX1
27	small molecule metabolic process	GO:044281	8.4	NAGLU, TRIB3, GCH1, AASS, UGCG, XDH
28	positive regulation of apoptotic process	GO:043065	8.3	FAS, AGT, PLA2G4A, SOD1, PTGS2, TSPO
29	negative regulation of apoptotic process	GO:043066	8.3	MAD2L1, CASP3, CAT, TP53, TNF, THBS1
30	anti-apoptosis	GO:006916	8.2	TNF, EPO, SOD1, THBS1, IL2, HMOX1
31	negative regulation of cell proliferation	GO:008285	7.8	AGT, PTGS2, TP53, JUN, IL8, FGF2
32	apoptotic process	GO:006915	7.5	TSPO, TRIB3, TP53, TNF, CYCS, EPO
33	response to drug	GO:042493	7.0	PPARG, JUN, THBS1, FAS, CCND1, CDH1
34	positive regulation of transcription, DNA-dependent	GO:045893	6.9	TP53, CDH1, JUN, ATF4, TNF, PPARG
35	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.8	FGF2, ATF4, JUN, IL2, TP53, TNF

Molecular functions related to anoxia according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	calcium:sodium antiporter activity	GO:005432	10.3	SLC8A1, SLC8A3, SLC8A2
2	flavin adenine dinucleotide binding	GO:050660	9.9	ACOX1, NOS2, XDH, GSR, CYBB, NOS1
3	iron ion binding	GO:005506	9.8	CYCS, NOS2, NGB, NOS1, XDH, CYGB
4	integrin binding	GO:005178	9.8	GFAP, VCAM1, THBS1, ADAM10, CTGF, ICAM1
5	NADP binding	GO:050661	9.5	NOS1, CAT, GSR, NOS2
6	heme binding	GO:020037	9.2	PTGS2, CYBB, CYCS, CYGB, NOS1, HMOX1
7	protein kinase binding	GO:019901	8.7	TRIB3, TP53, ELAVL1, CCND1, STAT3, PRKAB1
8	protein homodimerization activity	GO:042803	8.5	MAD2L1, GCH1, XDH, JUN, GSR, CAT
9	enzyme binding	GO:019899	7.9	TP53, STAT1, PPARG, HIF1A, CCND1, PTGS2
10	protein binding	GO:005515	3.2	GABBR1, PPARG, CYCS, CYBB, TNF, TP53