MCID: ANT034
MIFTS: 53

Anterior Uveitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Anterior Uveitis

MalaCards integrated aliases for Anterior Uveitis:

Name: Anterior Uveitis 49 69
Acute Anterior Uveitis 69 28
Iridocyclitis 49 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Summaries for Anterior Uveitis

MalaCards based summary : Anterior Uveitis, also known as acute anterior uveitis, is related to uveitis and spondylitis. An important gene associated with Anterior Uveitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Methotrexate and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Anterior Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.8 CTLA4 HLA-B IL2RA TNF
2 spondylitis 30.7 HLA-B IL6 TNF
3 choroiditis 30.5 CFH TNF
4 cytomegalovirus retinitis 30.1 HLA-B TNF
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 CTLA4 PTPN22
6 pneumonia 30.0 IL6 TLR4 TNF
7 cysticercosis 29.9 IL6 TLR4
8 rubella 29.9 HLA-A HLA-B TNF
9 multifocal choroiditis 29.9 CFH TNF
10 spondyloarthropathy 29.8 HLA-A HLA-B IL6 TNF
11 panuveitis 29.8 HLA-B TNF
12 arthritis 29.7 IL6 PTPN22 TNF
13 crohn's disease 29.7 IL6 TLR4 TNF
14 ulcerative colitis 29.7 IL6 TLR4 TNF
15 colitis 29.6 IL6 TLR4 TNF
16 reactive arthritis 29.6 HLA-B IL6 TNF
17 q fever 29.5 TLR4 TNF
18 stromal keratitis 29.3 IL2RA IL6 TNF
19 cytomegalovirus infection 29.3 IL2RA IL6 TNF
20 graft-versus-host disease 29.1 HLA-A HLA-B IL6 TNF
21 psoriatic arthritis 29.0 HLA-B PTPN22 TNF
22 multiple sclerosis 29.0 CTLA4 IL2RA IL6 TNF
23 acquired immunodeficiency syndrome 28.9 HLA-B IL2RA IL6 TNF
24 common variable immunodeficiency 28.7 CTLA4 IL2RA IL6 TNF
25 psoriasis 28.6 IL2RA IL6 PTPN22 TNF
26 vogt-koyanagi-harada disease 28.5 HLA-A HLA-B IL2RA PTPN22
27 inflammatory bowel disease 28.0 CTLA4 HLA-B IL6 PTPN22 TLR4 TNF
28 diabetes mellitus 28.0 CTLA4 IL2RA IL6 PTPN22 TNF
29 rheumatoid arthritis 27.6 CTLA4 HLA-B IL6 PTPN22 TLR4 TNF
30 infectious anterior uveitis 12.3
31 idiopathic anterior uveitis 12.2
32 blau syndrome 11.0
33 systemic onset juvenile idiopathic arthritis 11.0
34 phenytoin or carbamazepine toxicity 10.4 HLA-A HLA-B
35 postherpetic neuralgia 10.4 HLA-A HLA-B
36 atrial tachyarrhythmia with short pr interval 10.4 HLA-A HLA-B
37 glaucomatocyclitic crisis 10.4 HLA-A HLA-B
38 spondyloarthropathy 1 10.4
39 inflammatory spondylopathy 10.4
40 pars planitis 10.4 HLA-A HLA-B
41 pityriasis rosea 10.4 HLA-A HLA-B
42 endometrial disease 10.4 IL6 TLR4
43 enterocolitis 10.3 CFH TLR4
44 microscopic polyangiitis 10.3 HLA-B TNF
45 idiopathic bronchiectasis 10.3 HLA-A HLA-B
46 scorpion envenomation 10.3 IL6 TNF
47 histoplasmosis 10.3 HLA-A HLA-B
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
49 critical limb ischemia 10.3 IL6 TNF
50 bacteriuria 10.3 IL6 TLR4

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to Anterior Uveitis

Symptoms & Phenotypes for Anterior Uveitis

GenomeRNAi Phenotypes related to Anterior Uveitis according to GeneCards Suite gene sharing:

25 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.85 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.85 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.85 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.85 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.85 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.85 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.85 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.85 HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.85 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.85 HLA-A HLA-B IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.85 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.85 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.85 HLA-A HLA-B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.85 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.85 IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.85 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 HLA-A HLA-B
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.85 HLA-A HLA-B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.85 IL2RA

MGI Mouse Phenotypes related to Anterior Uveitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 TNF CTLA4 IL2RA IL6 PTPN22 TLR4
2 hematopoietic system MP:0005397 9.8 TNF CFH CTLA4 IL2RA IL6 PTPN22
3 immune system MP:0005387 9.7 TNF CFH CTLA4 IL2RA IL6 PTPN22
4 liver/biliary system MP:0005370 9.35 TNF CTLA4 IL6 PTPN22 TLR4
5 respiratory system MP:0005388 9.1 TNF CTLA4 IL2RA IL6 PTPN22 TLR4

Drugs & Therapeutics for Anterior Uveitis

Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
2
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
3
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
4
Certolizumab pegol Approved Phase 4 428863-50-7
5
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
7 Folic Acid Antagonists Phase 4
8 Ganciclovir triphosphate Phase 4
9 Nucleic Acid Synthesis Inhibitors Phase 4
10 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
11 Dermatologic Agents Phase 4,Phase 3
12 Vitamin B Complex Phase 4
13 Hormones Phase 4,Phase 3,Phase 2,Phase 1
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
15 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
16 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Antimetabolites Phase 4
18 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
19 Antimetabolites, Antineoplastic Phase 4
20 Antirheumatic Agents Phase 4,Phase 3
21 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2
22 beta-endorphin Phase 4
23 Adrenocorticotropic Hormone Phase 4
24 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1
25 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
26 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
27 Melanocyte-Stimulating Hormones Phase 4
28 Folate Nutraceutical Phase 4
29 Vitamin B9 Nutraceutical Phase 4
30
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1 50-24-8 5755
31
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1 83-43-2 6741
32
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
33
Ephedrine Approved Phase 3,Phase 1,Phase 2 299-42-3 9294
34
Triamcinolone Approved, Vet_approved Phase 3,Phase 2 124-94-7 31307
35
Pseudoephedrine Approved Phase 3,Phase 1,Phase 2 90-82-4 7028
36
Difluprednate Approved Phase 3,Phase 2 23674-86-4 443936
37
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
38 Acyclovir Phase 3
39 Prednisolone acetate Phase 3,Phase 2,Phase 1
40 glucocorticoids Phase 3,Phase 2,Phase 1
41 Methylprednisolone acetate Phase 3,Phase 2,Phase 1
42 Methylprednisolone Hemisuccinate Phase 3,Phase 2,Phase 1
43 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
44 Neuroprotective Agents Phase 3,Phase 2,Phase 1
45 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
46 Antiemetics Phase 3,Phase 2,Phase 1
47 Prednisolone hemisuccinate Phase 3,Phase 2,Phase 1
48 Prednisolone phosphate Phase 3,Phase 2,Phase 1
49 Protective Agents Phase 3,Phase 2,Phase 1
50 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 54)

# Name Status NCT ID Phase Drugs
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
2 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Completed NCT02897115 Phase 4
3 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
4 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Recruiting NCT02769702 Phase 4 Acthar
5 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
6 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4 Methotrexate
7 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
8 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
9 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
10 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
11 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
12 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
13 Study of Difluprednate in the Treatment of Uveitis Completed NCT00501579 Phase 3 Difluprednate;Prednisolone Acetate
14 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3 Acyclovir
15 A Phase 3 Study to Evaluate ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
16 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Recruiting NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
17 A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis Recruiting NCT03129100 Phase 3 Ixekizumab;Placebo
18 A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis Recruiting NCT02757352 Phase 3 Ixekizumab;Placebo
19 A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis Recruiting NCT02696798 Phase 3 Ixekizumab;Placebo
20 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Active, not recruiting NCT01148225 Phase 3 adalimumab
21 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Active, not recruiting NCT03097315 Phase 3
22 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Active, not recruiting NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
23 A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis Active, not recruiting NCT02696785 Phase 3 Ixekizumab;Placebo;Adalimumab
24 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3 Dexamethasone
25 Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis Completed NCT02482129 Phase 2 LME636 60 mg/mL ophthalmic solution;Dexamethasone 0.1% ophthalmic solution;LME636 Vehicle
26 A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis Completed NCT02406209 Phase 2 NS2;Prednisolone acetate ophthalmic suspension (1%)
27 Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2 8% Dexamethasone Sodium Phosphate - Visulex;15% Dexamethasone Sodium Phosphate - Visulex;Prednisolone Acetate (1%) Eye Drops
28 Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis Completed NCT00823173 Phase 2
29 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
30 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
31 Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis Completed NCT00694135 Phase 2 EGP-437 1.6 mA-min at 0.4 with EyeGate® II System;EGP-437 4.8 mA-min at 1.2 mA with EyeGate® II System;EGP-437 10.0 mA-min at 2.5 mA with EyeGate® II System;EGP-437 14.0 mA-min at 3.5 mA with EyeGate® II System
32 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2 Interferon Gamma-1b
33 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2 4 mg CLS-TA;0.8 mg CLS-TA
34 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
35 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti Completed NCT00876434 Phase 1 Sirolimus
36 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1 Gamunex-C
37 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
38 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
39 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Etanercept, Methotrexate, Prednisolone
40 Quality of Life and Visual Function in Uveitis Patients Unknown status NCT00407316 Early Phase 1
41 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
42 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Ganciclovir
43 Cyclosporine A in the Treatment of Juvenile Idiopathic Arthritis (JIA) Associated Chronic Anterior Uveitis Completed NCT00404482 Cyclosporine A
44 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed NCT00476593 Diclofenac;Dexamethasone
45 Aqueous Humor Dynamics and Hypertensive Uveitis Completed NCT02765308
46 Intraocular Pressure (IOP) Assessed by Dynamic Contour Tonometer (DCT) and Goldman Applanation Tonometry (GAT) Completed NCT00552019
47 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
48 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
49 Diagnostic Criteria in the Diagnosis of Spinal Spondyloarthropathies in Patients With Chronic Low Back Pain (Study P05320)(COMPLETED) Completed NCT00726765
50 Ocular Sarcoidosis Open Label Trial of ACTHAR Gel Recruiting NCT02725177 Repository Corticotropin Injection;Repository Corticotropin Injection -Treatment Extension

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Anterior Uveitis

Genetic tests related to Anterior Uveitis:

# Genetic test Affiliating Genes
1 Acute Anterior Uveitis 28

Anatomical Context for Anterior Uveitis

MalaCards organs/tissues related to Anterior Uveitis:

38
Eye, Endothelial, T Cells, Breast, Skin, Neutrophil, Lymph Node

Publications for Anterior Uveitis

Articles related to Anterior Uveitis:

(show top 50) (show all 644)
# Title Authors Year
1
Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers. ( 29377783 )
2018
2
Association of IL33 and IL1RAP polymorphisms with acute anterior uveitis. ( 29424312 )
2018
3
Tonic Pupil in Cytomegalovirus Anterior Uveitis in an Immunocompetent Adult Male - A Case Report. ( 29028408 )
2018
4
Anterior uveitis. ( 29290458 )
2018
5
Clinical Features of CMV-Associated Anterior Uveitis. ( 29172842 )
2018
6
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
7
Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013. ( 29415753 )
2018
8
Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 29424310 )
2018
9
MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats. ( 29434444 )
2017
10
Mapping Retinal and Choroidal Thickness in Unilateral Nongranulomatous Acute Anterior Uveitis Using Three-Dimensional 1060-nm Optical Coherence Tomography. ( 28973324 )
2017
11
The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. ( 28914578 )
2017
12
Acute Bilateral Anterior Uveitis after a Single Intravenous Infusion of Zoledronic Acid in Metastatic Breast Cancer. ( 28682020 )
2017
13
Document of treatment recommendations for non-infectious anterior uveitis. ( 28911893 )
2017
14
Fibrinous anterior uveitis and recurrent epithelial erosion following topical tetracaine abuse. ( 28521706 )
2017
15
Rare case of herpes zoster ophthalmicus with orbital myositis, oculomotor nerve palsy and anterior uveitis. ( 28195080 )
2017
16
Efficacy and safety of an extemporaneous preparation of 2% ganciclovir eye drops in CMV anterior uveitis. ( 29354718 )
2017
17
Case-control Study on Dactylitis, Enthesitis, and Anterior Uveitis in Spondyloarthritis Associated with Inflammatory Bowel Diseases: Role of Coexistent Psoriasis. ( 28412702 )
2017
18
Chikungunya Virus Infection Associated with Encephalitis and Anterior Uveitis. ( 29020499 )
2017
19
The Effect of Anterior Uveitis and Previously Undiagnosed Spondyloarthritis: Results from the DUET Cohort. ( 28668811 )
2017
20
Long-term results of cataract surgery in patients with anterior uveitis. ( 28602016 )
2017
21
Sacroiliac Joint Magnetic Resonance Imaging in Asymptomatic Patients with Recurrent Acute Anterior Uveitis: A Proof-of-concept Study. ( 29093157 )
2017
22
Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review. ( 29049193 )
2017
23
Review for Disease of the Year: Varicella Zoster Virus-Induced Anterior Uveitis. ( 29023181 )
2017
24
ADJUVITE: a double-blind, randomised, placebo-controlled trial of adalimumab in early onset, chronic, juvenile idiopathic arthritis-associated anterior uveitis. ( 29275333 )
2017
25
Anterior segment optical coherence tomography and retained vegetal intraocular foreign body masquerading as chronic anterior uveitis. ( 28536985 )
2017
26
Risk Factors for Secondary Glaucoma in Herpetic Anterior Uveitis. ( 28666730 )
2017
27
Choroidal change in acute anterior uveitis associated with human leukocyte antigen-B27. ( 28658315 )
2017
28
Imbalance of Th17/Treg cells in pathogenesis of patients with human leukocyte antigen B27 associated acute anterior uveitis. ( 28091550 )
2017
29
Comparison of the Diagnostic Power of Serum IL-6, IL-8 and TNF-I+ for the Idiopathic Anterior Uveitis in Children. ( 29226649 )
2017
30
Anticentromere antibody positive Ackerman's Syndrome with Granulomatous Anterior Uveitis. ( 28605750 )
2017
31
Challenges of Diagnosing Viral Anterior Uveitis. ( 29020537 )
2017
32
Cytomegalovirus Anterior Uveitis Following Topical Cyclosporine A. ( 28448732 )
2017
33
Analysis of choroidal and central foveal thicknesses in acute anterior uveitis by enhanced-depth imaging optical coherence tomography. ( 29191218 )
2017
34
In vivo Confocal Microscopy of Posner-Schlossman Syndrome: Comparison with herpes simplex keratitis, HLA-B27 anterior uveitis and acute attack of primary angle closure. ( 28852187 )
2017
35
Topical Ganciclovir in Cytomegalovirus Anterior Uveitis. ( 28426277 )
2017
36
Difluprednate 0.05% versus Prednisolone Acetate 1% for Endogenous Anterior Uveitis: Pooled Efficacy Analysis of Two Phase 3 Studies. ( 29260952 )
2017
37
Clinical features of HLA-B27-positive acute anterior uveitis with or without ankylosing spondylitis in a Chinese cohort. ( 28607176 )
2017
38
Multimodal Imaging in Anterior Uveitis. ( 28696173 )
2017
39
An unusual case of bilateral anterior uveitis related to moxifloxacin: the first report in Latin America. ( 28706771 )
2017
40
Bilateral Acute Anterior Uveitis and Conjunctivitis following Intravenous Zoledronic Acid. ( 28792180 )
2017
41
Botulinum toxin-induced acute anterior uveitis in a patient with BehAset's disease under infliximab treatment: a case report. ( 28468639 )
2017
42
Can we use the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume values for the diagnosis of anterior uveitis in patients with Behcet's disease? ( 28769565 )
2017
43
A Case of Immunoglobulin G4-associated Anterior Uveitis and Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome. ( 27192095 )
2016
44
HLA-B27 Anterior Uveitis: Immunology and Immunopathology. ( 27245590 )
2016
45
Serum Vitamin D Levels in Patients with Acute Anterior Uveitis. ( 27002415 )
2016
46
Anterior Uveitis Caused by Ocular Side Effects of Afatinib: A Case Report. ( 26933433 )
2016
47
CFHR2-rs2986127 as a genetic protective marker for acute anterior uveitis in Chinese patients. ( 27306586 )
2016
48
Corneal Endothelium in Patients with Anterior Uveitis. ( 27262766 )
2016
49
Cytomegalovirus as a cause of hypertensive anterior uveitis in immunocompetent patients. ( 27613273 )
2016
50
Efficacy and safety of topical ganciclovir in the management of cytomegalovirus (CMV)-related anterior uveitis. ( 26976016 )
2016

Variations for Anterior Uveitis

Expression for Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for Anterior Uveitis

Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CFH CTLA4 HLA-A HLA-B IL2RA IL6
2
Show member pathways
13.17 HLA-A HLA-B IL2RA IL6 TNF
3
Show member pathways
12.67 HLA-A HLA-B IL2RA IL6 TLR4 TNF
4
Show member pathways
12.41 IL2RA IL6 TLR4 TNF
5 12.37 CTLA4 IL2RA PTPN22 TNF
6
Show member pathways
12.37 CTLA4 HLA-A HLA-B IL2RA IL6 TNF
7
Show member pathways
12.32 HLA-A HLA-B IL6 TLR4 TNF
8 12.25 HLA-A HLA-B IL2RA
9
Show member pathways
12.12 HLA-A HLA-B IL2RA IL6 TLR4 TNF
10
Show member pathways
12.11 IL6 TLR4 TNF
11
Show member pathways
12.11 IL6 TLR4 TNF
12 12.08 IL6 TLR4 TNF
13 12.06 HLA-A HLA-B IL2RA IL6 TNF
14
Show member pathways
12.03 IL6 TLR4 TNF
15 12.03 IL6 TLR4 TNF
16 12.01 HLA-A HLA-B IL6
17 11.98 HLA-A HLA-B TLR4
18
Show member pathways
11.97 HLA-A HLA-B IL6 TNF
19 11.95 CTLA4 HLA-A HLA-B
20 11.86 IL6 TLR4 TNF
21 11.84 IL2RA IL6 TNF
22
Show member pathways
11.78 IL6 TLR4 TNF
23 11.75 IL2RA IL6 TNF
24 11.73 IL6 TLR4 TNF
25
Show member pathways
11.6 CTLA4 IL2RA TNF
26 11.59 IL6 TLR4 TNF
27 11.58 CTLA4 IL6 TLR4 TNF
28
Show member pathways
11.49 HLA-A IL2RA TNF
29 11.43 IL6 TLR4 TNF
30 11.36 IL6 TLR4 TNF
31
Show member pathways
11.24 IL2RA TNF
32 11.22 IL6 TNF
33 11.2 IL6 TLR4 TNF
34 11.18 IL6 TNF
35 11.16 IL6 TNF
36 11.14 IL6 TNF
37 11.05 HLA-A HLA-B
38 10.99 IL6 TNF
39 10.9 IL6 TNF
40 10.84 CTLA4 IL2RA IL6 TLR4 TNF

GO Terms for Anterior Uveitis

Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.72 CTLA4 HLA-A HLA-B TLR4 TNF
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B
3 external side of plasma membrane GO:0009897 9.26 CTLA4 IL2RA TLR4 TNF
4 MHC class I protein complex GO:0042612 9.16 HLA-A HLA-B
5 cell surface GO:0009986 9.02 HLA-A HLA-B IL2RA TLR4 TNF

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 IL2RA IL6 TLR4 TNF
2 positive regulation of gene expression GO:0010628 9.78 IL6 PTPN22 TLR4 TNF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 PTPN22 TLR4 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 IL6 TLR4 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.69 IL6 TLR4 TNF
6 negative regulation of T cell proliferation GO:0042130 9.6 CTLA4 IL2RA
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.59 HLA-A HLA-B
8 positive regulation of interleukin-8 production GO:0032757 9.58 TLR4 TNF
9 negative regulation of interleukin-6 production GO:0032715 9.57 TLR4 TNF
10 positive regulation of NF-kappaB import into nucleus GO:0042346 9.56 TLR4 TNF
11 negative regulation of immune response GO:0050777 9.54 CTLA4 IL2RA
12 regulation of regulatory T cell differentiation GO:0045589 9.52 CTLA4 IL2RA
13 positive regulation of interleukin-6 production GO:0032755 9.5 IL6 TLR4 TNF
14 negative regulation of lipid storage GO:0010888 9.46 IL6 TNF
15 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.43 HLA-A HLA-B
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 PTPN22 TLR4 TNF
17 immune system process GO:0002376 9.43 CTLA4 HLA-A HLA-B IL2RA PTPN22 TLR4
18 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.4 TLR4 TNF
19 protection from natural killer cell mediated cytotoxicity GO:0042270 9.37 HLA-A HLA-B
20 positive regulation of chemokine production GO:0032722 9.33 IL6 TLR4 TNF
21 immune response GO:0006955 9.17 CTLA4 HLA-A HLA-B IL2RA IL6 TLR4

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-A HLA-B

Sources for Anterior Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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