MCID: ANT034
MIFTS: 51

Anterior Uveitis malady

Rare diseases, Eye diseases categories

Summaries for Anterior Uveitis

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34MalaCards
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MalaCards: Anterior Uveitis, also known as acute anterior uveitis, is related to uveitis and ankylosing spondylitis. An important gene associated with Anterior Uveitis is CCR2 (chemokine (C-C motif) receptor 2), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and MSP-RON Signaling. The compounds tc 14012 and sb 225002 have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are pigmentation and tumorigenesis.

Aliases & Classifications for Anterior Uveitis

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Aliases & Descriptions:

anterior uveitis 44
acute anterior uveitis 63
iridocyclitis 44


Related Diseases for Anterior Uveitis

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18GeneCards, 19GeneDecks
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Diseases in the Intermediate Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Uveitis anterior uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis32.2CXCR1
2ankylosing spondylitis31.2KIR2DL2
3multiple sclerosis30.4CCR2, CXCR1, FASLG
4vogt-koyanagi-harada disease30.1FASLG, FAS
5acquired immunodeficiency syndrome30.1KIR2DL2, CCR2
6graft versus host disease30.1FASLG, FAS
7hepatitis30.1FAS, FASLG
8hepatitis c30.0FAS, TLR4
9rheumatoid arthritis30.0TLR4, FAS, FASLG, CXCR1
10autoimmune thyroiditis29.9FAS, FASLG
11systemic lupus erythematosus29.8FAS, TLR4, FASLG
12leukemia29.8FAS, FASLG, CXCR1, TLR4
13spondylitis10.7
14retinitis10.7
15arthritis10.6
16juvenile rheumatoid arthritis10.5
17idiopathic anterior uveitis10.5
18glaucoma10.5
19hypopyon10.5
20cataract10.4
21keratitis10.4
22spondyloarthropathy10.4
23herpes simplex10.4
24vasculitis10.4
25nephritis10.4
26fuchs' heterochromic uveitis10.4
27retinal vasculitis10.3
28interstitial nephritis10.3
29pneumonia10.3
30rubella10.3
31infectious anterior uveitis10.3
32herpes zoster10.3
33conjunctivitis10.3
34scleritis10.3
35syphilis10.3
36klebsiella10.3
37endotheliitis10.3
38lens-induced iridocyclitis10.2
39chikungunya10.2
40toxoplasmosis10.2
41scotoma10.2
42choroiditis10.2
43granuloma annulare10.2
44behcet's disease10.2
45breast cancer10.2
46corneal edema10.2
47corneal ulcer10.2
48diabetes mellitus10.2
49encephalomyelitis10.2
50endophthalmitis10.2

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to anterior uveitis

Symptoms for Anterior Uveitis

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Drugs & Therapeutics for Anterior Uveitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Anterior Uveitis

Drug clinical trials:

Search ClinicalTrials for Anterior Uveitis

Search NIH Clinical Center for Anterior Uveitis

Search CenterWatch for Anterior Uveitis

Genetic Tests for Anterior Uveitis

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Anatomical Context for Anterior Uveitis

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34MalaCards
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MalaCards organs/tissues related to Anterior Uveitis:

34
Eye, T cells, Endothelial, Breast, Skin, Lymph node, Lung, Testes, Thyroid, Kidney, Tongue, Spinal cord, Prostate

Animal Models for Anterior Uveitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Anterior Uveitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2CCR2, FAS, TLR4
2MP:00020068.9CCR2, FASLG, FAS, TLR4
3MP:00053708.9TLR4, FAS, FASLG, CCR2
4MP:00053678.9TLR4, FAS, FASLG, CCR2
5MP:00053888.7TLR4, FAS, FASLG, CCR2
6MP:00053908.7CCR2, FASLG, FAS, TLR4
7MP:00053818.6CCR2, FASLG, FAS, TLR4
8MP:00053918.4TLR4, FAS, FASLG, CCR2

Publications for Anterior Uveitis

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53PubMed
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Articles related to Anterior Uveitis:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Intracameral steroids versus subconjunctival and systemic steroids: Prevention of postoperative inflammation in cataract with anterior uveitis. (24355739)
2014
2
Factors Predictive of Remission of New-Onset Anterior Uveitis. (24342020)
2013
3
The diagnostic utility of anterior chamber paracentesis for polymerase chain reaction in anterior uveitis. (24053895)
2013
4
Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition. (23676143)
2013
5
The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study. (24204112)
2013
6
Treatment of recurrent anterior uveitis with infliximab in patient with ankylosing spondylitis. (23108527)
2013
7
Anterior uveitis secondary to type II essential cryoglobulinemia. (23883484)
2013
8
Acute anterior uveitis in Sydney. (23252660)
2013
9
Retinal thickening in HLA-B27-associated acute anterior uveitis: evolution with time and association with severity of inflammatory activity. (22879410)
2012
10
Brimonidine (Alphagan) associated anterior uveitis. (22257785)
2012
11
Corneal biomechanical properties in patients with recurrent anterior uveitis. (22794524)
2012
12
Anterior uveitis after treatment of hepatitis C with alpha interferon: the recurrence of a previous inflammatory process due to presumed ocular toxocariasis. (22324899)
2012
13
Lymphoplasmacytic endotheliitis and anterior uveitis in sheep infected experimentally with rift valley fever virus. (21601870)
2012
14
Acute anterior uveitis and optic neuritis as ocular complications of influenza A infection in an 11-year-old boy. (21732577)
2011
15
Cytomegalovirus anterior uveitis: outcome of treatment. (20576767)
2010
16
Macular thickening in acute anterior uveitis with a 6-month remission period. (20130729)
2010
17
Anterior uveitis associated with high-dose cytosine arabinoside. (20887203)
2010
18
Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis. (20680102)
2010
19
Fibrinous anterior uveitis following laser in situ keratomileusis. (19574707)
2009
20
Bilateral anterior uveitis after intense pulsed light therapy for pigmented eyelid lesions. (18554285)
2008
21
A high viral load of Epstein-Barr virus DNA in ocular fluids in an HLA-B27-negative acute anterior uveitis patient with psoriasis. (18626741)
2008
22
Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. (18245272)
2008
23
Bilateral anterior uveitis associated with clomiphene citrate. (18379937)
2008
24
Bilateral acute anterior uveitis as a side effect of trimethoprim. (16751748)
2007
25
Anterior uveitis, poliosis, and skin hypopigmentation associated with topical chloramphenicol allergy following ptosis surgery. (17667109)
2007
26
Case of anterior uveitis after intravitreal injection of bevacizumab. (16963867)
2006
27
Anterior uveitis and iris nodules that are associated with Langerhans cell histiocytosis. (16376670)
2005
28
Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept. (16052578)
2005
29
Chemokine receptors and early activation markers in acute anterior uveitis. (15043537)
2004
30
'Hyperacute' unilateral anterior uveitis and secondary glaucoma following streptokinase infusion. (14707996)
2004
31
Acute anterior uveitis. (15366165)
2003
32
Diagnosis and management of herpetic anterior uveitis. (12189614)
2002
33
Bilateral acute anterior uveitis after alendronate. (12446386)
2002
34
Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis. (11481266)
2001
35
Prevalence of subclinical anterior uveitis in adult patients with inflammatory bowel disease. (11159490)
2001
36
Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE. (11687534)
2001
37
Autoantibodies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele. (11935433)
2001
38
Diagnosing and treating herpetic anterior uveitis. (11097582)
2000
39
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
40
Posterior segment inflammation in HLA-B27+ acute anterior uveitis: clinical characteristics. (10420203)
1999
41
Takayansu's Arteritis Associated with Anterior Uveitis and Cutaneous Extravascular Necrotizing Granuloma. (19078330)
1998
42
Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. (9892502)
1998
43
Association between MICA gene A4 allele and acute anterior uveitis in white patients with and without HLA-B27. (9744378)
1998
44
Experimental autoimmune anterior uveitis (EAAU): induction by melanin antigen and suppression by various treatments. (8502620)
1993
45
Nonpenetrating trauma in the right eye induces anterior uveitis and secondary glaucoma in the contralateral eye. (8363296)
1993
46
Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium. (2037026)
1991
47
Systemic sulfonamides as a cause of bilateral, anterior uveitis. (1987952)
1991
48
Remission of anterior uveitis by subconjunctival fluorouracil. (1987929)
1991
49
Serum fibrin degradation products in acute idiopathic anterior uveitis. (3811876)
1986
50
Central Scotoma in Anterior Uveitis: A Further Contribution. (16692615)
1922

Variations for Anterior Uveitis

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Expression for genes affiliated with Anterior Uveitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for genes affiliated with Anterior Uveitis

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Sources:
51PathCards, 55R&D Systems, 56Reactome, 54QIAGEN, 31KEGG, 61Thomson Reuters, 39NCBI BioSystems Database, 5Cell Signaling Technology, 58SinoBiological
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Pathways related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CCR2, CXCR1
29.7CCR2, TLR4
39.7TLR4, CCR2
49.5FASLG, FAS
59.5FAS, FASLG
6
Show member pathways
FAS pathway and Stress induction of HSP regulation39
Apoptosis and survival FAS signaling cascades61
Caspase cascade in apoptosis39
9.5FASLG, FAS
7
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
9.5FAS, FASLG
8
Show member pathways
TRAIL signaling pathway39
9.5FASLG, FAS
9
Show member pathways
9.5FASLG, FAS
10
Show member pathways
9.5FASLG, FAS
119.5FAS, TLR4
129.2CCR2, FASLG, FAS
139.1KIR2DL2, KIR2DS3
14
Show member pathways
9.1FASLG, FAS, TLR4
15
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.1TLR4, FAS, FASLG
16
Show member pathways
9.1TLR4, FAS, FASLG
17
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1FASLG, FAS, TLR4
18
Show member pathways
9.1FASLG, FAS, TLR4
199.1TLR4, FAS, FASLG
20
Show member pathways
8.4CCR2, CXCR1, FASLG, FAS, TLR4
21
Show member pathways
7.6FAS, FASLG, KIR2DS3, KIR2DL2, KIR2DL5A
22
Show member pathways
Immune response CD16 signaling in NK cells61
7.6KIR2DL5A, KIR2DL2, KIR2DS3, FASLG, FAS

Compounds for genes affiliated with Anterior Uveitis

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Sources:
62Tocris Bioscience, 30IUPHAR, 46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 25HMDB
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Compounds related to Anterior Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1tc 140126210.2CXCR1, CCR2
2sb 22500262 3011.2CXCR1, CCR2
3sb 2656106210.2CXCR1, CCR2
4rs 5043936210.2CXCR1, CCR2
5maraviroc46 62 52 30 1214.2CCR2, CXCR1
6imiquimod46 62 30 1213.0FASLG, TLR4
7(glc)44610.0FASLG, FAS
8atpo30 4611.0FAS, FASLG
9teniposide46 1210.9FASLG, FAS
10concanamycin a46 6210.9FASLG, FAS
112-chlorodeoxyadenosine469.9FASLG, FAS
12mannan469.9KIR2DL2, TLR4
13dutp469.8FAS, FASLG
143-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.8FAS, FASLG
15depsipeptide469.8FASLG, FAS
16suberoylanilide hydroxamic acid469.8FAS, FASLG
17fludarabine46 52 1211.8FASLG, FAS
18ccl346 3010.8CXCR1, TLR4
19infliximab46 52 1211.7TLR4, FAS
20calyculin a46 62 1211.7FAS, FASLG
21ivig469.7FAS, FASLG
22endotoxin469.6CXCR1, FASLG, TLR4
23rottlerin469.5FAS, FASLG
24ag 1478469.5FASLG, FAS
25ifn-alpha469.5TLR4, FAS, FASLG
26c2ceramide469.5TLR4, FAS, FASLG
27tgf beta1469.5FASLG, FAS, TLR4
28agarose469.5TLR4, FAS, FASLG
29ceramide469.5TLR4, FAS, FASLG
30n acetylcysteine469.5TLR4, FAS, FASLG
31sb 20358046 6210.5TLR4, FAS, FASLG
32polysaccharide469.4FASLG, FAS, TLR4
33paclitaxel46 52 1211.4FASLG, FAS, TLR4
34ly294002469.4FASLG, FAS, TLR4
35cyclosporin a46 30 6211.3FASLG, FAS, TLR4
36lactate469.3FASLG, FAS, TLR4
37daunorubicin46 52 1211.2FASLG, FAS
38rantes469.2CXCR1, FASLG, FAS, TLR4
39wortmannin469.2TLR4, FAS, FASLG, CXCR1
40actinomycin d469.2TLR4, FAS, FASLG, CXCR1
41cisplatin46 52 62 1212.2FASLG, FAS, TLR4
42genistein46 30 62 3 25 1214.2TLR4, FAS, FASLG, CXCR1
43cycloheximide469.2TLR4, FAS, FASLG, CXCR1
44dexamethasone46 52 30 1212.1CXCR1, FASLG, FAS, TLR4
45vegf469.1TLR4, FAS, FASLG, CXCR1
46phosphatidylinositol469.1TLR4, FAS, FASLG, CXCR1
47retinoic acid46 2510.1TLR4, FAS, FASLG, CXCR1
48cysteine469.0TLR4, FAS, FASLG, CXCR1
49aspartate469.0FASLG, FAS, TLR4
50tyrosine468.5TLR4, FAS, FASLG, CXCR1, KIR2DL5A

GO Terms for genes affiliated with Anterior Uveitis

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17Gene Ontology
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Cellular components related to Anterior Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484719.3CCR2, FASLG, TLR4
2external side of plasma membraneGO:0098979.1FASLG, FAS, TLR4
3integral component of plasma membraneGO:0058878.1TLR4, FASLG, CCR2, KIR2DS3
4plasma membraneGO:0058867.5TLR4, FAS, CXCR1, CCR2, KIR2DL2, KIR2DL5A

Biological processes related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:00240710.0CCR2, CXCR1
2chemokine-mediated signaling pathwayGO:07009810.0CCR2, CXCR1
3positive regulation of tumor necrosis factor biosynthetic processGO:0425359.9CCR2, TLR4
4inflammatory cell apoptotic processGO:0069259.8FASLG, FAS
5necroptotic signaling pathwayGO:0975279.8FASLG, FAS
6positive regulation of interferon-gamma productionGO:0327299.8CCR2, TLR4
7regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.8FAS, FASLG
8extrinsic apoptotic signaling pathwayGO:0971919.7FAS, FASLG
9positive regulation of inflammatory responseGO:0507299.7TLR4, CCR2
10negative regulation of angiogenesisGO:0165259.7CCR2, FASLG
11extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7FAS, FASLG
12activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.5FASLG, FAS
13immune responseGO:0069559.4CCR2, FASLG, TLR4
14cellular defense responseGO:0069689.2KIR2DS3, CCR2
15cellular response to mechanical stimulusGO:0712609.2FAS, TLR4

Molecular functions related to Anterior Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.8CCR2, CXCR1

Products for genes affiliated with Anterior Uveitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anterior Uveitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet