MCID: ANT034
MIFTS: 28

Anterior Uveitis malady

Summaries for Anterior Uveitis

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32MalaCards
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MalaCards: Anterior Uveitis, also known as acute anterior uveitis, is related to uveitis and ankylosing spondylitis. An important gene associated with Anterior Uveitis is CXCR1 (chemokine (C-X-C motif) receptor 1), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds (glc)4 and tc 14012 have been mentioned in the context of this disorder.

Aliases & Classifications for Anterior Uveitis

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

anterior uveitis 42
acute anterior uveitis 60
iridocyclitis 42


Related Diseases for Anterior Uveitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Intermediate Uveitis anterior uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 192)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis32.0CXCR1
2ankylosing spondylitis31.0KIR2DL2
3arthritis30.8TLR4, PTPN22, CXCR1, PSMB9
4keratitis30.6TLR4
5multiple sclerosis30.3PTPN22, FASLG, CCR2, CXCR1
6diabetes mellitus30.2PTPN22
7inflammatory bowel disease30.2TLR4
8psoriasis30.2CXCR1, KIR2DL3, KIR2DS1, PTPN22, CX3CL1
9tuberculosis30.1CXCR1, TLR4, CX3CL1
10hepatitis30.0FASLG
11vogt-koyanagi-harada disease30.0FAS, FASLG
12influenza30.0PSMB9, KIR2DL2
13hepatitis c30.0PSMB9, TLR4, FAS
14rheumatoid arthritis29.9TLR4, FAS, FASLG, CXCR1, CX3CL1, KIR2DL1
15vitiligo29.7PTPN22
16autoimmune thyroiditis29.7PTPN22, PSMB9, FASLG, FAS
17leukemia29.7TLR4, FASLG, FAS, KIR2DS4, CXCR1
18systemic lupus erythematosus29.7TLR4, FASLG, PTPN22, FAS
19spondylitis10.7
20retinitis10.6
21juvenile rheumatoid arthritis10.5
22glaucoma10.5
23hypopyon10.4
24cataract10.4
25spondyloarthropathy10.4
26herpes simplex10.3
27vasculitis10.3
28infectious anterior uveitis10.3
29retinal vasculitis10.3
30posterior uveitis10.3
31interstitial nephritis10.3
32pneumonia10.3
33rubella10.2
34herpes zoster10.2
35anterior scleritis10.2
36conjunctivitis10.2
37corneal ulcer10.2
38scleritis10.2
39syphilis10.2
40idiopathic anterior uveitis10.2
41lens-induced iridocyclitis10.1
42chikungunya10.1
43toxoplasmosis10.1
44choroiditis10.1
45scotoma10.1
46behcet's disease10.1
47granuloma annulare10.1
48breast cancer10.1
49corneal edema10.1
50encephalomyelitis10.1

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to anterior uveitis

Clinical Features for Anterior Uveitis

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Drugs & Therapeutics for Anterior Uveitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Anterior Uveitis

Drug clinical trials:

Search ClinicalTrials for Anterior Uveitis

Search NIH Clinical Center for Anterior Uveitis

Search CenterWatch for Anterior Uveitis

Genetic Tests for Anterior Uveitis

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Anatomical Context for Anterior Uveitis

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Animal Models for Anterior Uveitis or affiliated genes

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Publications for Anterior Uveitis

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Genetic Variations for Anterior Uveitis

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Expression for genes affiliated with Anterior Uveitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for genes affiliated with Anterior Uveitis

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 52R&D Systems, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3FASLG, FAS
210.3FASLG, FAS
3
Immune response Bacterial infections in normal airways
10.2TLR4, FAS, FASLG
4
Hide members
10.2FASLG, FAS, TLR4
510.2CX3CL1, CXCR1, CCR2
610.2CX3CL1, TLR4, CCR2
710.1CCR2, FAS, FASLG, PTPN22
8
Hide members
10.0CCR2, TLR4, FAS, FASLG, CXCR1, CX3CL1
9
Hide members
10.0KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DS1
10
Hide members
9.9KIR2DS2, KIR3DS1, KIR2DS1, KIR2DS4, KIR2DS5
11
Hide members
9.6KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR3DS1, KIR2DS1
12
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9.5KIR2DS4, KIR2DS1, KIR2DS2, KIR2DL2, KIR2DS3, KIR2DL5A
13
Hide members
9.4KIR2DS5, FAS, FASLG, KIR2DS4, KIR2DS1, KIR2DS2

Compounds for genes affiliated with Anterior Uveitis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 11DrugBank
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Compounds related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1(glc)44410.6FASLG, FAS
2tc 140125910.6CCR2, CXCR1
3sb 22500259 2811.5CCR2, CXCR1
4sb 2656105910.5CCR2, CXCR1
5ifn-alpha4410.5TLR4, FAS, FASLG
6c2ceramide4410.5FASLG, FAS, TLR4
7rs 5043935910.5CCR2, CXCR1
8atpo44 2811.4FAS, FASLG
9rantes4410.4TLR4, FAS, FASLG, CXCR1
10maraviroc44 59 49 28 1114.3CCR2, CXCR1
11teniposide44 1111.3FASLG, FAS
12wortmannin4410.1CXCR1, FASLG, FAS, TLR4
13cysteine4410.0TLR4, FAS, FASLG, CXCR1, CX3CL1, KIR2DS4
14tyrosine449.9PTPN22, TLR4, FAS, FASLG, CXCR1, KIR2DL3
15actinomycin d449.9TLR4, FAS, FASLG, CXCR1

GO Terms for genes affiliated with Anterior Uveitis

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Sources:
16Gene Ontology
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Cellular components related to Anterior Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.6TLR4, FASLG, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1
2plasma membraneGO:0058868.8KIR2DS5, CCR2, TLR4, FAS, CXCR1, CX3CL1

Biological processes related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.4FASLG, FAS
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.3FAS, FASLG
3positive regulation of inflammatory responseGO:05072910.3CCR2, TLR4, CX3CL1
4positive regulation of tumor necrosis factor biosynthetic processGO:04253510.2CCR2, TLR4
5chemotaxisGO:00693510.2CX3CL1, CXCR1, CCR2
6regulation of immune responseGO:05077610.1KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DS1
7dendritic cell chemotaxisGO:00240710.0CXCR1, CCR2
8innate immune responseGO:0450879.9CCR2, TLR4, KIR2DS2, KIR3DS1, KIR2DS1, KIR2DS4
9immune responseGO:0069559.7KIR2DS5, CCR2, TLR4, FASLG, CX3CL1, KIR2DL3

Molecular functions related to Anterior Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.3CXCR1, CCR2
2transmembrane signaling receptor activityGO:00488810.0KIR2DS1, KIR2DS2, FAS, TLR4
3receptor activityGO:0048729.8TLR4, FAS, KIR2DL3, KIR2DL1

Products for genes affiliated with Anterior Uveitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anterior Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet