MCID: ANT034
MIFTS: 54

Anterior Uveitis malady

Rare diseases, Eye diseases categories
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Summaries for Anterior Uveitis

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MalaCards based summary: Anterior Uveitis, also known as iridocyclitis, is related to uveitis and ankylosing spondylitis. An important gene associated with Anterior Uveitis is CCR2 (chemokine (C-C motif) receptor 2), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and MSP-RON Signaling. The drugs scopolamine and scopolamine hydrobromide and the compounds tc 14012 and sb 225002 have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are pigmentation and tumorigenesis.

Aliases & Classifications for Anterior Uveitis

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Anterior Uveitis, Aliases & Descriptions:

Name: Anterior Uveitis 42
Iridocyclitis 42 62
 
Acute Anterior Uveitis 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases


Related Diseases for Anterior Uveitis

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Diseases in the Intermediate Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Uveitis anterior uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis32.8CXCR1
2ankylosing spondylitis31.8KIR2DL2
3multiple sclerosis30.6CCR2, CXCR1, FASLG
4vogt-koyanagi-harada disease30.4FASLG, FAS
5acquired immunodeficiency syndrome30.4KIR2DL2, CCR2
6graft versus host disease30.3FASLG, FAS
7hepatitis30.3FAS, FASLG
8autoimmune thyroiditis30.1FAS, FASLG
9hepatitis c30.1FAS, TLR4
10rheumatoid arthritis29.9TLR4, FAS, FASLG, CXCR1
11systemic lupus erythematosus29.9FAS, TLR4, FASLG
12leukemia29.6FAS, FASLG, CXCR1, TLR4
13spondylitis10.7
14retinitis10.7
15arthritis10.6
16juvenile rheumatoid arthritis10.6
17idiopathic anterior uveitis10.5
18spondyloarthropathy10.5
19cataract10.5
20hypopyon10.5
21keratitis10.5
22fuchs' heterochromic uveitis10.5
23herpes simplex10.4
24vasculitis10.4
25nephritis10.4
26rubella10.3
27retinal vasculitis10.3
28interstitial nephritis10.3
29pneumonia10.3
30infectious anterior uveitis10.3
31herpes zoster10.3
32scleritis10.3
33syphilis10.3
34klebsiella10.3
35endotheliitis10.3
36pyelonephritis10.3CXCR1, TLR4
37lens-induced iridocyclitis10.3
38sjogren's syndrome10.2FAS, FASLG
39toxic epidermal necrolysis10.2FAS, FASLG
40silicosis10.2FASLG, FAS
41lymphomatoid papulosis10.2FAS, FASLG
42stevens-johnson syndrome10.2FAS, FASLG
43autoimmune lymphoproliferative syndrome10.2FASLG, FAS
44aplastic anemia10.2FAS, FASLG
45chikungunya10.2
46toxoplasmosis10.2
47phacoanaphylactic uveitis10.2
48idiopathic pulmonary fibrosis10.2FASLG, CXCR1
49lymphopenia10.2FAS, FASLG
50behcet's disease10.2

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to anterior uveitis

Symptoms for Anterior Uveitis

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Drugs & Therapeutics for Anterior Uveitis

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Drug clinical trials:

Search ClinicalTrials for Anterior Uveitis

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Anterior Uveitis

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Anatomical Context for Anterior Uveitis

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MalaCards organs/tissues related to Anterior Uveitis:

32
Eye, T cells, Endothelial, Breast, Skin, Lymph node, Spinal cord, Kidney, Lung, Thyroid, Prostate, Testes, Tongue, Neutrophil

Animal Models for Anterior Uveitis or affiliated genes

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MGI Mouse Phenotypes related to Anterior Uveitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2CCR2, FAS, TLR4
2MP:00020068.9CCR2, FASLG, FAS, TLR4
3MP:00053708.9TLR4, FAS, FASLG, CCR2
4MP:00053678.9TLR4, FAS, FASLG, CCR2
5MP:00053888.7TLR4, FAS, FASLG, CCR2
6MP:00053908.7CCR2, FASLG, FAS, TLR4
7MP:00053818.6CCR2, FASLG, FAS, TLR4
8MP:00053918.4TLR4, FAS, FASLG, CCR2

Publications for Anterior Uveitis

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Articles related to Anterior Uveitis:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus. (25124341)
2014
2
Chitosan oligosaccharides attenuate ocular inflammation in rats with experimental autoimmune anterior uveitis. (25147441)
2014
3
Anterior segment optical coherence tomography in acute anterior uveitis. (25076363)
2014
4
Intracameral steroids versus subconjunctival and systemic steroids: Prevention of postoperative inflammation in cataract with anterior uveitis. (24355739)
2014
5
Factors Predictive of Remission of New-Onset Anterior Uveitis. (24342020)
2013
6
The diagnostic utility of anterior chamber paracentesis for polymerase chain reaction in anterior uveitis. (24053895)
2013
7
Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition. (23676143)
2013
8
The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study. (24204112)
2013
9
Treatment of recurrent anterior uveitis with infliximab in patient with ankylosing spondylitis. (23108527)
2013
10
Anterior uveitis secondary to type II essential cryoglobulinemia. (23883484)
2013
11
Acute anterior uveitis in Sydney. (23252660)
2013
12
Retinal thickening in HLA-B27-associated acute anterior uveitis: evolution with time and association with severity of inflammatory activity. (22879410)
2012
13
Brimonidine (Alphagan) associated anterior uveitis. (22257785)
2012
14
Corneal biomechanical properties in patients with recurrent anterior uveitis. (22794524)
2012
15
Anterior uveitis after treatment of hepatitis C with alpha interferon: the recurrence of a previous inflammatory process due to presumed ocular toxocariasis. (22324899)
2012
16
Lymphoplasmacytic endotheliitis and anterior uveitis in sheep infected experimentally with rift valley fever virus. (21601870)
2012
17
Acute anterior uveitis and optic neuritis as ocular complications of influenza A infection in an 11-year-old boy. (21732577)
2011
18
Cytomegalovirus anterior uveitis: outcome of treatment. (20576767)
2010
19
Macular thickening in acute anterior uveitis with a 6-month remission period. (20130729)
2010
20
Anterior uveitis associated with high-dose cytosine arabinoside. (20887203)
2010
21
Quantitative assessment of the effects of pupillary dilation on aqueous flare in eyes with chronic anterior uveitis using laser flare photometry. (20502943)
2010
22
Fibrinous anterior uveitis following laser in situ keratomileusis. (19574707)
2009
23
Bilateral anterior uveitis after intense pulsed light therapy for pigmented eyelid lesions. (18554285)
2008
24
A high viral load of Epstein-Barr virus DNA in ocular fluids in an HLA-B27-negative acute anterior uveitis patient with psoriasis. (18626741)
2008
25
Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. (18245272)
2008
26
Bilateral anterior uveitis associated with clomiphene citrate. (18379937)
2008
27
Bilateral acute anterior uveitis as a side effect of trimethoprim. (16751748)
2007
28
Anterior uveitis, poliosis, and skin hypopigmentation associated with topical chloramphenicol allergy following ptosis surgery. (17667109)
2007
29
Case of anterior uveitis after intravitreal injection of bevacizumab. (16963867)
2006
30
Anterior uveitis and iris nodules that are associated with Langerhans cell histiocytosis. (16376670)
2005
31
Chemokine receptors and early activation markers in acute anterior uveitis. (15043537)
2004
32
'Hyperacute' unilateral anterior uveitis and secondary glaucoma following streptokinase infusion. (14707996)
2004
33
Acute anterior uveitis. (15366165)
2003
34
Diagnosis and management of herpetic anterior uveitis. (12189614)
2002
35
Bilateral acute anterior uveitis after alendronate. (12446386)
2002
36
Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis. (11481266)
2001
37
Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE. (11687534)
2001
38
Autoantibodies specificity in acute anterior uveitis according to the presence of the HLA-B27 allele. (11935433)
2001
39
Diagnosing and treating herpetic anterior uveitis. (11097582)
2000
40
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
41
Posterior segment inflammation in HLA-B27+ acute anterior uveitis: clinical characteristics. (10420203)
1999
42
Takayansu's Arteritis Associated with Anterior Uveitis and Cutaneous Extravascular Necrotizing Granuloma. (19078330)
1998
43
Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. (9892502)
1998
44
Association between MICA gene A4 allele and acute anterior uveitis in white patients with and without HLA-B27. (9744378)
1998
45
Experimental autoimmune anterior uveitis (EAAU): induction by melanin antigen and suppression by various treatments. (8502620)
1993
46
Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium. (2037026)
1991
47
Systemic sulfonamides as a cause of bilateral, anterior uveitis. (1987952)
1991
48
Remission of anterior uveitis by subconjunctival fluorouracil. (1987929)
1991
49
Serum fibrin degradation products in acute idiopathic anterior uveitis. (3811876)
1986
50
Central Scotoma in Anterior Uveitis: A Further Contribution. (16692615)
1922

Variations for Anterior Uveitis

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Expression for genes affiliated with Anterior Uveitis

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Expression patterns in normal tissues for genes affiliated with Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for genes affiliated with Anterior Uveitis

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Pathways related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CCR2, CXCR1
29.7CCR2, TLR4
39.7TLR4, CCR2
49.5FASLG, FAS
59.5FAS, FASLG
6
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.5FASLG, FAS
7
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.5FAS, FASLG
8
Show member pathways
TRAIL signaling pathway37
9.5FASLG, FAS
9
Show member pathways
9.5FASLG, FAS
10
Show member pathways
9.5FASLG, FAS
119.5FAS, TLR4
129.2CCR2, FASLG, FAS
139.1KIR2DL2, KIR2DS3
14
Show member pathways
9.1FASLG, FAS, TLR4
15
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1TLR4, FAS, FASLG
16
Show member pathways
9.1TLR4, FAS, FASLG
17
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1FASLG, FAS, TLR4
18
Show member pathways
9.1FASLG, FAS, TLR4
199.1TLR4, FAS, FASLG
20
Show member pathways
8.4CCR2, CXCR1, FASLG, FAS, TLR4
21
Show member pathways
7.6FAS, FASLG, KIR2DS3, KIR2DL2, KIR2DL5A
22
Show member pathways
Immune response CD16 signaling in NK cells60
7.6KIR2DL5A, KIR2DL2, KIR2DS3, FASLG, FAS

Compounds for genes affiliated with Anterior Uveitis

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Compounds related to Anterior Uveitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1tc 140126110.2CXCR1, CCR2
2sb 22500261 2811.2CXCR1, CCR2
3sb 2656106110.2CXCR1, CCR2
4rs 5043936110.2CXCR1, CCR2
5maraviroc44 61 50 28 1114.2CCR2, CXCR1
6imiquimod44 61 28 1113.0FASLG, TLR4
7(glc)44410.0FASLG, FAS
8atpo28 4411.0FAS, FASLG
9teniposide44 1110.9FASLG, FAS
10concanamycin a44 6110.9FASLG, FAS
112-chlorodeoxyadenosine449.9FASLG, FAS
12mannan449.9KIR2DL2, TLR4
13dutp449.8FAS, FASLG
143-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.8FAS, FASLG
15depsipeptide449.8FASLG, FAS
16suberoylanilide hydroxamic acid449.8FAS, FASLG
17fludarabine44 50 1111.8FASLG, FAS
18ccl344 2810.8CXCR1, TLR4
19infliximab44 50 1111.7TLR4, FAS
20calyculin a44 61 1111.7FAS, FASLG
21ivig449.7FAS, FASLG
22endotoxin449.6CXCR1, FASLG, TLR4
23rottlerin449.5FAS, FASLG
24ag 1478449.5FASLG, FAS
25ifn-alpha449.5TLR4, FAS, FASLG
26c2ceramide449.5TLR4, FAS, FASLG
27tgf beta1449.5FASLG, FAS, TLR4
28agarose449.5TLR4, FAS, FASLG
29ceramide449.5TLR4, FAS, FASLG
30n acetylcysteine449.5TLR4, FAS, FASLG
31sb 20358044 6110.5TLR4, FAS, FASLG
32polysaccharide449.4FASLG, FAS, TLR4
33paclitaxel44 50 1111.4FASLG, FAS, TLR4
34ly294002449.4FASLG, FAS, TLR4
35cyclosporin a44 28 6111.3FASLG, FAS, TLR4
36lactate449.3FASLG, FAS, TLR4
37daunorubicin44 50 1111.2FASLG, FAS
38rantes449.2CXCR1, FASLG, FAS, TLR4
39wortmannin449.2TLR4, FAS, FASLG, CXCR1
40actinomycin d449.2TLR4, FAS, FASLG, CXCR1
41cisplatin44 50 61 1112.2FASLG, FAS, TLR4
42genistein44 28 61 2 24 1114.2TLR4, FAS, FASLG, CXCR1
43cycloheximide449.2TLR4, FAS, FASLG, CXCR1
44dexamethasone44 50 28 1112.1CXCR1, FASLG, FAS, TLR4
45vegf449.1TLR4, FAS, FASLG, CXCR1
46phosphatidylinositol449.1TLR4, FAS, FASLG, CXCR1
47retinoic acid44 2410.1TLR4, FAS, FASLG, CXCR1
48cysteine449.0TLR4, FAS, FASLG, CXCR1
49aspartate449.0FASLG, FAS, TLR4
50tyrosine448.5TLR4, FAS, FASLG, CXCR1, KIR2DL5A

GO Terms for genes affiliated with Anterior Uveitis

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Cellular components related to Anterior Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484719.3CCR2, FASLG, TLR4
2external side of plasma membraneGO:0098979.1FASLG, FAS, TLR4
3integral component of plasma membraneGO:0058878.1TLR4, FASLG, CCR2, KIR2DS3
4plasma membraneGO:0058867.5TLR4, FAS, CXCR1, CCR2, KIR2DL2, KIR2DL5A

Biological processes related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:00240710.0CCR2, CXCR1
2chemokine-mediated signaling pathwayGO:07009810.0CCR2, CXCR1
3positive regulation of tumor necrosis factor biosynthetic processGO:0425359.9CCR2, TLR4
4inflammatory cell apoptotic processGO:0069259.8FASLG, FAS
5necroptotic signaling pathwayGO:0975279.8FASLG, FAS
6positive regulation of interferon-gamma productionGO:0327299.8CCR2, TLR4
7regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.8FAS, FASLG
8extrinsic apoptotic signaling pathwayGO:0971919.7FAS, FASLG
9positive regulation of inflammatory responseGO:0507299.7TLR4, CCR2
10negative regulation of angiogenesisGO:0165259.7CCR2, FASLG
11extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7FAS, FASLG
12activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.5FASLG, FAS
13immune responseGO:0069559.4CCR2, FASLG, TLR4
14cellular defense responseGO:0069689.2KIR2DS3, CCR2
15cellular response to mechanical stimulusGO:0712609.2FAS, TLR4

Molecular functions related to Anterior Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:0049509.8CCR2, CXCR1

Products for genes affiliated with Anterior Uveitis

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  • Antibodies
  • Proteins
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Sources for Anterior Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet