Aliases & Classifications for Anterior Uveitis

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Anterior Uveitis, Aliases & Descriptions:

Name: Anterior Uveitis 41 60
Iridocyclitis 41 60
 
Acute Anterior Uveitis 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Anterior Uveitis

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MalaCards based summary: Anterior Uveitis, also known as iridocyclitis, is related to uveitis and spondyloarthropathy 1. An important gene associated with Anterior Uveitis is CCR2 (chemokine (C-C motif) receptor 2), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and MSP-RON Signaling. The drugs scopolamine and scopolamine hydrobromide and the compounds tc 14012 and sb 225002 have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related mouse phenotypes are pigmentation and tumorigenesis.

Related Diseases for Anterior Uveitis

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Diseases in the Uveitis family:

Infectious Anterior Uveitis Posterior Uveitis
Intermediate Uveitis anterior uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis32.8CXCR1
2spondyloarthropathy 130.7KIR2DL2
3vogt-koyanagi-harada disease30.4FASLG, FAS
4hepatitis30.3FAS, FASLG
5hepatitis c30.1FAS, TLR4
6systemic lupus erythematosus29.9FAS, TLR4, FASLG
7rheumatoid arthritis29.9TLR4, FAS, FASLG, CXCR1
8leukemia29.6FAS, FASLG, CXCR1, TLR4
9spondylitis10.8
10retinitis10.7
11arthritis10.6
12juvenile rheumatoid arthritis10.6
13idiopathic anterior uveitis10.6
14hypopyon10.5
15cataract10.5
16spondyloarthropathy10.5
17fuchs' heterochromic uveitis10.4
18keratitis10.4
19herpes simplex10.4
20pneumonia10.4
21vasculitis10.4
22nephritis10.4
23rubella10.3
24infectious anterior uveitis10.3
25retinal vasculitis10.3
26interstitial nephritis10.3
27lens-induced iridocyclitis10.3
28herpes zoster10.3
29choroiditis10.3
30conjunctivitis10.3
31scleritis10.3
32syphilis10.3
33endotheliitis10.3
34pyelonephritis10.3CXCR1, TLR4
35sjogren's syndrome10.2FAS, FASLG
36silicosis10.2FASLG, FAS
37acquired immunodeficiency syndrome10.2KIR2DL2, CCR2
38lymphomatoid papulosis10.2FAS, FASLG
39hypersensitivity syndrome, carbamazepine-induced10.2FAS, FASLG
40autoimmune lymphoproliferative syndrome10.2FASLG, FAS
41gonococcal iridocyclitis10.2
42chikungunya10.2
43toxoplasmosis10.2
44phacoanaphylactic uveitis10.2
45aplastic anemia10.2FAS, FASLG
46pulmonary fibrosis, idiopathic10.2FASLG, CXCR1
47lymphopenia10.2FAS, FASLG
48breast cancer10.2
49behcet's disease10.2
50crohn's disease10.2

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to anterior uveitis

Symptoms for Anterior Uveitis

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Drugs & Therapeutics for Anterior Uveitis

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Drug clinical trials:

Search ClinicalTrials for Anterior Uveitis

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Anterior Uveitis

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Anatomical Context for Anterior Uveitis

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MalaCards organs/tissues related to Anterior Uveitis:

31
Eye, T cells, Endothelial, Breast, Skin, Lymph node, Spinal cord, Kidney, Lung, Thyroid, Prostate, Testes, Tongue, Neutrophil

Animal Models for Anterior Uveitis or affiliated genes

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MGI Mouse Phenotypes related to Anterior Uveitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2CCR2, FAS, TLR4
2MP:00020068.9CCR2, FASLG, FAS, TLR4
3MP:00053708.9TLR4, FAS, FASLG, CCR2
4MP:00053678.9TLR4, FAS, FASLG, CCR2
5MP:00053888.7TLR4, FAS, FASLG, CCR2
6MP:00053908.7CCR2, FASLG, FAS, TLR4
7MP:00053818.6CCR2, FASLG, FAS, TLR4
8MP:00053918.4TLR4, FAS, FASLG, CCR2

Publications for Anterior Uveitis

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Articles related to Anterior Uveitis:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Aqueous cell differentiation in anterior uveitis using fourier-domain optical coherence tomography. (25650415)
2015
2
Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus. (25124341)
2014
3
Chitosan oligosaccharides attenuate ocular inflammation in rats with experimental autoimmune anterior uveitis. (25147441)
2014
4
Anterior segment optical coherence tomography in acute anterior uveitis. (25076363)
2014
5
Toxic granulomatous anterior uveitis in live intracameral cysticercosis masquerading as leukocoria. (25433748)
2014
6
Intracameral steroids versus subconjunctival and systemic steroids: Prevention of postoperative inflammation in cataract with anterior uveitis. (24355739)
2014
7
FoxO1 gene confers genetic predisposition to acute anterior uveitis with ankylosing spondylitis. (25414190)
2014
8
Factors Predictive of Remission of New-Onset Anterior Uveitis. (24342020)
2013
9
The diagnostic utility of anterior chamber paracentesis for polymerase chain reaction in anterior uveitis. (24053895)
2013
10
Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition. (23676143)
2013
11
The association of human leukocyte antigen B27 with anterior uveitis in patients from the western region of Saudi Arabia: a retrospective study. (24204112)
2013
12
Treatment of recurrent anterior uveitis with infliximab in patient with ankylosing spondylitis. (23108527)
2013
13
Anterior uveitis secondary to type II essential cryoglobulinemia. (23883484)
2013
14
Acute anterior uveitis in Sydney. (23252660)
2013
15
Retinal thickening in HLA-B27-associated acute anterior uveitis: evolution with time and association with severity of inflammatory activity. (22879410)
2012
16
Brimonidine (Alphagan) associated anterior uveitis. (22257785)
2012
17
Corneal biomechanical properties in patients with recurrent anterior uveitis. (22794524)
2012
18
Acute anterior uveitis and optic neuritis as ocular complications of influenza A infection in an 11-year-old boy. (21732577)
2011
19
Cytomegalovirus anterior uveitis: outcome of treatment. (20576767)
2010
20
Macular thickening in acute anterior uveitis with a 6-month remission period. (20130729)
2010
21
Anterior uveitis associated with high-dose cytosine arabinoside. (20887203)
2010
22
Fibrinous anterior uveitis following laser in situ keratomileusis. (19574707)
2009
23
Bilateral anterior uveitis after intense pulsed light therapy for pigmented eyelid lesions. (18554285)
2008
24
A high viral load of Epstein-Barr virus DNA in ocular fluids in an HLA-B27-negative acute anterior uveitis patient with psoriasis. (18626741)
2008
25
Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. (18245272)
2008
26
Bilateral anterior uveitis associated with clomiphene citrate. (18379937)
2008
27
Bilateral acute anterior uveitis as a side effect of trimethoprim. (16751748)
2007
28
Anterior uveitis, poliosis, and skin hypopigmentation associated with topical chloramphenicol allergy following ptosis surgery. (17667109)
2007
29
Case of anterior uveitis after intravitreal injection of bevacizumab. (16963867)
2006
30
Anterior uveitis and iris nodules that are associated with Langerhans cell histiocytosis. (16376670)
2005
31
Chemokine receptors and early activation markers in acute anterior uveitis. (15043537)
2004
32
'Hyperacute' unilateral anterior uveitis and secondary glaucoma following streptokinase infusion. (14707996)
2004
33
Acute anterior uveitis. (15366165)
2003
34
Diagnosis and management of herpetic anterior uveitis. (12189614)
2002
35
Bilateral acute anterior uveitis after alendronate. (12446386)
2002
36
Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis. (11481266)
2001
37
Prevalence of subclinical anterior uveitis in adult patients with inflammatory bowel disease. (11159490)
2001
38
Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE. (11687534)
2001
39
Diagnosing and treating herpetic anterior uveitis. (11097582)
2000
40
Classification of herpes simplex virus keratitis and anterior uveitis. (10090358)
1999
41
Posterior segment inflammation in HLA-B27+ acute anterior uveitis: clinical characteristics. (10420203)
1999
42
Takayansu's Arteritis Associated with Anterior Uveitis and Cutaneous Extravascular Necrotizing Granuloma. (19078330)
1998
43
Humoral immune response to Klebsiella capsular polysaccharides in HLA-B27-positive patients with acute anterior uveitis and ankylosing spondylitis. (9892502)
1998
44
Association between MICA gene A4 allele and acute anterior uveitis in white patients with and without HLA-B27. (9744378)
1998
45
Experimental autoimmune anterior uveitis (EAAU): induction by melanin antigen and suppression by various treatments. (8502620)
1993
46
Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium. (2037026)
1991
47
Systemic sulfonamides as a cause of bilateral, anterior uveitis. (1987952)
1991
48
Remission of anterior uveitis by subconjunctival fluorouracil. (1987929)
1991
49
Serum fibrin degradation products in acute idiopathic anterior uveitis. (3811876)
1986
50
Central Scotoma in Anterior Uveitis: A Further Contribution. (16692615)
1922

Variations for Anterior Uveitis

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Expression for genes affiliated with Anterior Uveitis

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Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for genes affiliated with Anterior Uveitis

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Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CCR2, CXCR1
29.7CCR2, TLR4
39.7TLR4, CCR2
49.5FASLG, FAS
59.5FAS, FASLG
6
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.5FASLG, FAS
7
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.5FAS, FASLG
8
Show member pathways
TRAIL signaling pathway36
9.5FASLG, FAS
9
Show member pathways
9.5FASLG, FAS
10
Show member pathways
9.5FASLG, FAS
119.5FAS, TLR4
129.2CCR2, FASLG, FAS
139.1KIR2DL2, KIR2DS3
14
Show member pathways
9.1FASLG, FAS, TLR4
15
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.1TLR4, FAS, FASLG
16
Show member pathways
9.1TLR4, FAS, FASLG
17
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1FASLG, FAS, TLR4
18
Show member pathways
9.1FASLG, FAS, TLR4
199.1TLR4, FAS, FASLG
20
Show member pathways
8.4CCR2, CXCR1, FASLG, FAS, TLR4
21
Show member pathways
7.6FAS, FASLG, KIR2DS3, KIR2DL2, KIR2DL5A
22
Show member pathways
Immune response CD16 signaling in NK cells58
7.6KIR2DL5A, KIR2DL2, KIR2DS3, FASLG, FAS

Compounds for genes affiliated with Anterior Uveitis

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Compounds related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1tc 140125910.2CXCR1, CCR2
2sb 22500259 2811.2CXCR1, CCR2
3sb 2656105910.2CXCR1, CCR2
4rs 5043935910.2CXCR1, CCR2
5maraviroc43 59 49 28 1214.2CCR2, CXCR1
6imiquimod43 59 28 1213.0FASLG, TLR4
7(glc)44310.0FASLG, FAS
8atpo28 4311.0FAS, FASLG
9teniposide43 1210.9FASLG, FAS
10concanamycin a43 5910.9FASLG, FAS
112-chlorodeoxyadenosine439.9FASLG, FAS
12mannan439.9KIR2DL2, TLR4
13dutp439.8FAS, FASLG
143-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.8FAS, FASLG
15depsipeptide439.8FASLG, FAS
16suberoylanilide hydroxamic acid439.8FAS, FASLG
17fludarabine43 49 1211.8FASLG, FAS
18ccl343 2810.8CXCR1, TLR4
19infliximab43 49 1211.7TLR4, FAS
20calyculin a43 59 1211.7FAS, FASLG
21ivig439.7FAS, FASLG
22endotoxin439.6CXCR1, FASLG, TLR4
23rottlerin439.5FAS, FASLG
24ag 1478439.5FASLG, FAS
25ifn-alpha439.5TLR4, FAS, FASLG
26c2ceramide439.5TLR4, FAS, FASLG
27tgf beta1439.5FASLG, FAS, TLR4
28agarose439.5TLR4, FAS, FASLG
29ceramide439.5TLR4, FAS, FASLG
30n acetylcysteine439.5TLR4, FAS, FASLG
31sb 20358043 5910.5TLR4, FAS, FASLG
32polysaccharide439.4FASLG, FAS, TLR4
33paclitaxel43 49 1211.4FASLG, FAS, TLR4
34ly294002439.4FASLG, FAS, TLR4
35cyclosporin a43 28 5911.3FASLG, FAS, TLR4
36lactate439.3FASLG, FAS, TLR4
37daunorubicin43 49 1211.2FASLG, FAS
38rantes439.2CXCR1, FASLG, FAS, TLR4
39wortmannin439.2TLR4, FAS, FASLG, CXCR1
40actinomycin d439.2TLR4, FAS, FASLG, CXCR1
41cisplatin43 49 59 1212.2FASLG, FAS, TLR4
42genistein43 28 59 2 24 1214.2TLR4, FAS, FASLG, CXCR1
43cycloheximide439.2TLR4, FAS, FASLG, CXCR1
44dexamethasone43 49 28 1212.1CXCR1, FASLG, FAS, TLR4
45vegf439.1TLR4, FAS, FASLG, CXCR1
46phosphatidylinositol439.1TLR4, FAS, FASLG, CXCR1
47retinoic acid43 2410.1TLR4, FAS, FASLG, CXCR1
48cysteine439.0TLR4, FAS, FASLG, CXCR1
49aspartate439.0FASLG, FAS, TLR4
50tyrosine438.5TLR4, FAS, FASLG, CXCR1, KIR2DL5A

GO Terms for genes affiliated with Anterior Uveitis

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Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:00484719.3CCR2, FASLG, TLR4
2external side of plasma membraneGO:00098979.1FASLG, FAS, TLR4
3integral component of plasma membraneGO:00058878.1TLR4, FASLG, CCR2, KIR2DS3
4plasma membraneGO:00058867.5TLR4, FAS, CXCR1, CCR2, KIR2DL2, KIR2DL5A

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:000240710.0CCR2, CXCR1
2chemokine-mediated signaling pathwayGO:007009810.0CCR2, CXCR1
3positive regulation of tumor necrosis factor biosynthetic processGO:00425359.9CCR2, TLR4
4inflammatory cell apoptotic processGO:00069259.8FASLG, FAS
5necroptotic signaling pathwayGO:00975279.8FASLG, FAS
6positive regulation of interferon-gamma productionGO:00327299.8CCR2, TLR4
7regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012399.8FAS, FASLG
8extrinsic apoptotic signaling pathwayGO:00971919.7FAS, FASLG
9positive regulation of inflammatory responseGO:00507299.7TLR4, CCR2
10negative regulation of angiogenesisGO:00165259.7CCR2, FASLG
11extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7FAS, FASLG
12activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.5FASLG, FAS
13immune responseGO:00069559.4CCR2, FASLG, TLR4
14cellular defense responseGO:00069689.2KIR2DS3, CCR2
15cellular response to mechanical stimulusGO:00712609.2FAS, TLR4

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.8CCR2, CXCR1

Products for genes affiliated with Anterior Uveitis

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Sources for Anterior Uveitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet