MCID: ANT034
MIFTS: 48

Anterior Uveitis malady

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Anterior Uveitis

Aliases & Descriptions for Anterior Uveitis:

Name: Anterior Uveitis 50 69
Iridocyclitis 50 69
Acute Anterior Uveitis 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


Summaries for Anterior Uveitis

MalaCards based summary : Anterior Uveitis, also known as iridocyclitis, is related to choroiditis and bacterial meningitis. An important gene associated with Anterior Uveitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Dexamethasone and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Related Diseases for Anterior Uveitis

Diseases in the Uveitis family:

Posterior Uveitis Intermediate Uveitis
Infectious Anterior Uveitis Anterior Uveitis
Infectious Posterior Uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
id Related Disease Score Top Affiliating Genes
1 choroiditis 29.9 IL6 TLR4 TNF
2 bacterial meningitis 29.5 HLA-B IL6 TNF
3 neuropathy 29.5 IL6 TLR4 TNF
4 rift valley fever 29.4 IL6 TLR4 TNF
5 measles 29.4 IL6 TNF
6 histiocytosis 29.2 IL6 TLR2 TLR4 TNF
7 hepatitis 29.1 HLA-A HLA-B IL6 TNF
8 rheumatoid arthritis 28.6 IL2RA IL6 PTPN22 TLR2 TLR4 TNF
9 infectious anterior uveitis 12.2
10 idiopathic anterior uveitis 12.1
11 uveitis 10.9
12 blau syndrome 10.9
13 spondylitis 10.3
14 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 IL6 TNF
15 mirizzi syndrome 10.2 HLA-B TNF
16 dyslexia 5 10.2 IL6 TNF
17 aortic atherosclerosis 10.2 IL6 TNF
18 degenerative disc disease 10.2 IL6 TNF
19 unilateral multicystic dysplastic kidney 10.2 IL6 TNF
20 thymic neuroendocrine carcinoma 10.2 IL6 TNF
21 spondylometaphyseal dysplasia east-african type 10.2 TLR4 TNF
22 low compliance bladder 10.2 TLR4 TNF
23 drug dependence 10.2 IL6 TNF
24 solid pseudopapillary carcinoma of pancreas 10.2 HLA-A HLA-B
25 transient tic disorder 10.2 IL6 TNF
26 anal paget's disease 10.2 IL6 TNF
27 papilledema 10.2 IL6 TNF
28 sacral nerve root cysts 10.2 HLA-A HLA-B
29 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 IL6 TNF
30 amyotrophic lateral sclerosis type 5 10.2 IL2RA TNF
31 pseudoainhum 10.2 TLR2 TLR4
32 non-amyloid monoclonal immunoglobulin deposition disease 10.2 IL2RA PTPN22
33 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IL2RA TNF
34 myopathy, congenital nonprogressive, with moebius sequence and robin sequence 10.2 HLA-A HLA-B
35 epididymo-orchitis 10.2 HLA-A HLA-B
36 bipolar i disorder 10.2 IL6 TNF
37 retinitis 10.2
38 preaxial polydactyly of fingers 10.2 IL6 TNF
39 human immunodeficiency virus infectious disease 10.1 IL6 TNF
40 hernia of ovary and fallopian tube 10.1 HLA-A HLA-B
41 learning disability 10.1 HLA-A HLA-B
42 polyomavirus allograft nephropathy 10.1 IL2RA PTPN22
43 primary optic atrophy 10.1 TLR2 TLR4
44 arthritis 10.1
45 hypertensive heart disease 10.1 TLR2 TLR4
46 swine influenza 10.1 HLA-B IL6 TNF
47 esophagus lymphoma 10.1 IL6 TNF
48 follicular adenoma 10.1 HLA-B IL6 TNF
49 vogt-koyanagi-harada disease 10.1 IL6 TNF
50 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL6 TLR4 TNF

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to Anterior Uveitis

Symptoms & Phenotypes for Anterior Uveitis

GenomeRNAi Phenotypes related to Anterior Uveitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.85 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.85 HLA-B HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.85 HLA-B HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.85 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.85 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.85 HLA-B HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.85 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.85 HLA-B HLA-A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.85 IL2RA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.85 HLA-B IL2RA HLA-A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.85 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.85 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.85 HLA-B HLA-A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.85 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.85 IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.85 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 HLA-B HLA-A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.85 HLA-B HLA-A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.85 IL2RA

MGI Mouse Phenotypes related to Anterior Uveitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 PTPN22 TLR2 TLR4 TNF CFH IL2RA
2 digestive/alimentary MP:0005381 9.85 IL2RA IL6 PTPN22 TLR2 TLR4 TNF
3 immune system MP:0005387 9.8 CFH IL2RA IL6 PTPN22 TLR2 TLR4
4 liver/biliary system MP:0005370 9.55 IL6 PTPN22 TLR2 TLR4 TNF
5 renal/urinary system MP:0005367 9.35 CFH IL6 PTPN22 TLR2 TLR4
6 respiratory system MP:0005388 9.1 IL2RA IL6 PTPN22 TLR2 TLR4 TNF

Drugs & Therapeutics for Anterior Uveitis

Drugs for Anterior Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 159)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
2
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
3
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
5
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
6
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 124-94-7 31307
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
8
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 67-73-2 6215
9
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
10
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
11
Timolol Approved Phase 4 26839-75-8 33624 5478
12
Ephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 299-42-3 9294
13
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
14
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1,Phase 2 90-82-4 7028
15
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
16
Travoprost Approved Phase 4 157283-68-6 5282226
17
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
18
Certolizumab pegol Approved Phase 4 428863-50-7
19
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 54575, 6560146 143
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
21
Maleic acid Experimental Phase 4 110-16-7 444266
22 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Phase 1
23 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
24 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
25 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
26
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
27 Folic Acid Antagonists Phase 4,Phase 2
28 Ganciclovir triphosphate Phase 4
29 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Gentamicins Phase 4
32 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
33 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
35 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
37 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
38 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2,Phase 1
39 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Phase 1
40 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Phase 1
41 Hormones Phase 4,Phase 3,Phase 2,Phase 1
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
44 Vitamin B Complex Phase 4,Phase 2
45 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
46 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
47 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Phase 1
48 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
49 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 147)
id Name Status NCT ID Phase
1 Efficacy Comparison Study of Steroids to Control Post-operative Inflammation Unknown status NCT01801774 Phase 4
2 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4
3 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4
4 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
5 A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery Completed NCT00170729 Phase 4
6 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4
7 Aqueous Flare of a Hydrophobic Acrylic Single-piece Open-loop IOL With Modified Material Surface Properties Completed NCT01767012 Phase 4
8 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Recruiting NCT03020992 Phase 4
9 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4
10 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Recruiting NCT02897115 Phase 4
11 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Not yet recruiting NCT02769702 Phase 4
12 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Not yet recruiting NCT03133767 Phase 4
13 Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis Terminated NCT00918554 Phase 4
14 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4
15 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3
16 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3
17 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3
18 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3
19 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3
20 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3
21 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3
22 Study of Difluprednate in the Treatment of Uveitis Completed NCT00501579 Phase 3
23 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3
24 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3
25 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3
26 Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis Completed NCT01243983 Phase 3
27 Comparison of AC and PC Lenses After Vitreous Loss During ECCE Completed NCT00453011 Phase 3
28 Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation and Pain Completed NCT02508337 Phase 3
29 Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular Inflammation Completed NCT02235272 Phase 3
30 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3
31 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3
32 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3
33 Clinical Study of TA-650 in Patients With Behcet's Disease (BD) With Special Lesions Completed NCT01532570 Phase 3
34 A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's Disease Completed NCT01243671 Phase 3
35 Efficacy of Humira in Behcet Patients With Arthritis Completed NCT01497717 Phase 3
36 A Phase 3 Study to Evaluate ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3
37 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Recruiting NCT02517619 Phase 3
38 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Recruiting NCT03097315 Phase 3
39 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Recruiting NCT02595398 Phase 3
40 A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis Recruiting NCT03129100 Phase 3
41 A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis Recruiting NCT02757352 Phase 3
42 A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis Recruiting NCT02696798 Phase 3
43 A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis Recruiting NCT02696785 Phase 3
44 A Study to Evaluate Efficacy and Safety of Infliximab in Participant With Moderate-to-Severe Refractory Intestinal Behcet's Disease Recruiting NCT02505568 Phase 3
45 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Active, not recruiting NCT01148225 Phase 3
46 Loteprednol vs Prednisolone for the Treatment of Intraocular Inflammation Following Cataract Surgery in Children. Active, not recruiting NCT01475643 Phase 3
47 A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behcet's Disease Active, not recruiting NCT02307513 Phase 3
48 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3
49 Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implant Terminated NCT00456482 Phase 2, Phase 3
50 Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis Terminated NCT01103024 Phase 3

Search NIH Clinical Center for Anterior Uveitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Anterior Uveitis

Anatomical Context for Anterior Uveitis

MalaCards organs/tissues related to Anterior Uveitis:

39
Eye, T Cells, Endothelial, Skin, Breast, Tongue, Lymph Node

Publications for Anterior Uveitis

Articles related to Anterior Uveitis:

(show top 50) (show all 604)
id Title Authors Year
1
Imbalance of Th17/Treg cells in pathogenesis of patients with human leukocyte antigen B27 associated acute anterior uveitis. ( 28091550 )
2017
2
High Efficacy of Methotrexate in Patients with Recurrent Idiopathic Acute Anterior Uveitis: a Prospective Study. ( 27170318 )
2016
3
Different roles of TNF inhibitors in acute anterior uveitis associated with ankylosing spondylitis: state of the art. ( 27686662 )
2016
4
A Rare Patient With Orbital Apex Syndrome, Anterior Uveitis, and Necrotizing Scleritis Due to Herpes Zoster Ophthalmicus. ( 28005810 )
2016
5
CFHR2-rs2986127 as a genetic protective marker for acute anterior uveitis in Chinese patients. ( 27306586 )
2016
6
Association of Low Vitamin D Levels With Noninfectious Anterior Uveitis. ( 28006052 )
2016
7
Vision-Related Quality of Life in Patients with Inactive HLA-B27-Associated-Spectrum Anterior Uveitis. ( 26808922 )
2016
8
Bilateral Anterior Uveitis Associated with Nivolumab Therapy. ( 27599197 )
2016
9
Recurrent Bilateral Anterior Uveitis with Kikuchi-Fujimoto Disease. ( 27420799 )
2016
10
Clinical Features and Complications of the HLA-B27-associated Acute Anterior Uveitis: A Metanalysis. ( 27404944 )
2016
11
Hypopyon complicating the course of anterior uveitis in a patient with Behcet's syndrome. ( 27648274 )
2016
12
S100A8 promotes migration and infiltration of inflammatory cells in acute anterior uveitis. ( 27786310 )
2016
13
Cytomegalovirus as a cause of hypertensive anterior uveitis in immunocompetent patients. ( 27613273 )
2016
14
Usefulness of anterior uveitis as an additional tool for diagnosing incomplete Kawasaki disease. ( 27186227 )
2016
15
The role of Vitamin D in immuno-inflammatory responses in Ankylosing Spondylitis patients with and without Acute Anterior Uveitis. ( 27713770 )
2016
16
Bilateral neuroretinitis and anterior uveitis following ipilimumab treatment for metastatic melanoma. ( 27165193 )
2016
17
In vivo Confocal Microscopy in Differentiating Ipilimumab-Induced Anterior Uveitis from Metastatic Uveal Melanoma. ( 27790127 )
2016
18
Evolving "Diagnostic" Criteria for Axial Spondyloarthritis in the Context of Anterior Uveitis. ( 27070270 )
2016
19
Anterior uveitis as the first sign of human African trypanosomiasis: a case report. ( 27694095 )
2016
20
Multifocal choroiditis with panuveitis in an 8-year-old boy with long-standing idiopathic acute anterior uveitis. ( 26951535 )
2016
21
Genotype-phenotype Association Study Reveals CFI-Rs13104777 to be a Protective Genetic Marker Against Acute Anterior Uveitis. ( 27380463 )
2016
22
Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese. ( 27965977 )
2016
23
Corneal Endothelium in Patients with Anterior Uveitis. ( 27262766 )
2016
24
Description and Prevalence of Spondyloarthritis in Patients with Anterior Uveitis: The SENTINEL Interdisciplinary Collaborative Project. ( 27084561 )
2016
25
The Feasibility of Spectral-Domain Optical Coherence Tomography Grading of Anterior Chamber Inflammation in a Rabbit Model of Anterior Uveitis. ( 27409471 )
2016
26
Case of acute anterior uveitis and Vogt-Koyanagi-Harada syndrome-like eruptions induced by nivolumab in a melanoma patient. ( 27649838 )
2016
27
Association of CD59 and CFH polymorphisms with acute anterior uveitis in Chinese population. ( 27419833 )
2016
28
Changes in Corneal Thickness and Specular Microscopic Indices in Acute Unilateral Anterior Uveitis. ( 27182691 )
2016
29
Efficacy and safety of topical ganciclovir in the management of cytomegalovirus (CMV)-related anterior uveitis. ( 26976016 )
2016
30
Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis. ( 26893583 )
2016
31
In vivo confocal microscopy of inflammatory cells in the corneal subbasal nerve plexus in patients with different subtypes of anterior uveitis. ( 26823398 )
2016
32
The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis. ( 26610302 )
2016
33
Clinical Features and Prognosis of Herpetic Anterior Uveitis. ( 27800272 )
2016
34
Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis. ( 26708737 )
2016
35
Does the Microbiome Cause B27-related Acute Anterior Uveitis? ( 27002532 )
2016
36
Association of T-Bet, GATA-3, RORC, and FOXP3 Copy Number Variations With Acute Anterior Uveitis With or Without Ankylosing Spondylitis in Chinese Han. ( 27082299 )
2016
37
Chronic Anterior Uveitis in Children. ( 27191963 )
2016
38
Anterior Uveitis Caused by Ocular Side Effects of Afatinib: A Case Report. ( 26933433 )
2016
39
Acute Mycoplasma pneumoniae infection presenting with unilateral anterior uveitis and perineuritis. ( 27079602 )
2016
40
Unilateral Recurrent Anterior Uveitis as the Presenting Sign of Bladder Carcinoma. ( 28058157 )
2016
41
A Case of Immunoglobulin G4-associated Anterior Uveitis and Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome. ( 27192095 )
2016
42
Development and validation of a Bayesian network for the differential diagnosis of anterior uveitis. ( 27055672 )
2016
43
Serum Vitamin D Levels in Patients with Acute Anterior Uveitis. ( 27002415 )
2016
44
HLA-B27 Anterior Uveitis: Immunology and Immunopathology. ( 27245590 )
2016
45
Interesting case of severe anterior uveitis caused by brimonidine eye drops. ( 26265860 )
2015
46
Erlotinib-associated bilateral anterior uveitis: resolution with posterior sub-Tenon's triamcinolone without erlotinib cessation. ( 26455982 )
2015
47
Acute anterior uveitis and other extra-articular manifestations of spondyloarthritis. ( 26351533 )
2015
48
Expression profile of IL-1 family cytokines in aqueous humor and sera of patients with HLA-B27 associated anterior uveitis and idiopathic anterior uveitis. ( 26116905 )
2015
49
Association of Genetic Variations in TNFSF15 With Acute Anterior Uveitis in Chinese Han. ( 26200500 )
2015
50
Acute Anterior Uveitis and Spondyloarthritis: More Than Meets the Eye. ( 26233598 )
2015

Variations for Anterior Uveitis

Expression for Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for Anterior Uveitis

Pathways related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 45)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 CFH HLA-A HLA-B IL2RA IL6 PTPN22
2
Show member pathways
13.24 IL2RA IL6 TLR2 TLR4 TNF
3
Show member pathways
13.18 HLA-A HLA-B IL2RA IL6 TNF
4
Show member pathways
12.83 IL6 TLR2 TLR4 TNF
5
Show member pathways
12.75 IL6 TLR2 TLR4 TNF
6
Show member pathways
12.71 HLA-A HLA-B IL2RA IL6 TNF
7
Show member pathways
12.56 IL6 TLR2 TLR4 TNF
8 12.45 IL2RA IL6 TLR2 TLR4
9 12.41 IL2RA PTPN22 TLR2 TNF
10
Show member pathways
12.39 IL2RA IL6 TLR2 TLR4 TNF
11
Show member pathways
12.35 HLA-A HLA-B TLR2 TLR4
12
Show member pathways
12.19 IL6 TLR2 TNF
13
Show member pathways
12.19 HLA-A HLA-B IL2RA IL6 TLR2 TLR4
14 12.16 TLR2 TLR4 TNF
15
Show member pathways
12.15 IL6 TLR2 TLR4 TNF
16
Show member pathways
12.13 IL6 TLR4 TNF
17 12.13 HLA-A HLA-B IL2RA IL6 TNF
18
Show member pathways
12.11 TLR2 TLR4 TNF
19 12.11 IL6 TLR2 TLR4 TNF
20
Show member pathways
12.07 IL6 TLR2 TLR4 TNF
21 12.05 IL6 TLR2 TLR4 TNF
22
Show member pathways
12.01 HLA-A HLA-B IL6 TNF
23 11.99 HLA-A HLA-B TLR2 TLR4
24
Show member pathways
11.92 IL2RA TLR2 TLR4
25 11.89 IL6 TLR4 TNF
26 11.88 IL2RA IL6 TNF
27
Show member pathways
11.81 IL6 TLR2 TLR4
28 11.79 IL2RA IL6 TNF
29
Show member pathways
11.76 IL6 TLR2 TLR4 TNF
30 11.69 IL6 TLR2 TLR4 TNF
31 11.66 IL6 TLR4 TNF
32 11.62 IL6 TLR2 TLR4 TNF
33
Show member pathways
11.55 HLA-A IL2RA TNF
34 11.44 TLR2 TLR4 TNF
35 11.3 IL6 TLR2 TLR4 TNF
36 11.24 IL6 TLR4 TNF
37 11.23 IL6 TNF
38 11.19 IL6 TNF
39 11.17 IL6 TNF
40 11.16 IL6 TNF
41 11.15 IL6 TLR2 TLR4 TNF
42 11.06 HLA-A HLA-B
43 11 IL6 TNF
44 10.93 IL6 TNF
45 10.87 IL2RA IL6 TLR2 TLR4 TNF

GO Terms for Anterior Uveitis

Cellular components related to Anterior Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 HLA-A HLA-B TLR2 TLR4 TNF
2 intrinsic component of plasma membrane GO:0031226 9.37 TLR2 TLR4
3 phagocytic vesicle membrane GO:0030670 9.33 HLA-A HLA-B TLR2
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.32 HLA-A HLA-B
5 MHC class I protein complex GO:0042612 9.26 HLA-A HLA-B
6 external side of plasma membrane GO:0009897 9.26 IL2RA IL6 TLR4 TNF
7 cell surface GO:0009986 9.1 HLA-A HLA-B IL2RA TLR2 TLR4 TNF

Biological processes related to Anterior Uveitis according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 IL2RA IL6 TLR2 TLR4 TNF
2 response to lipopolysaccharide GO:0032496 9.83 IL6 PTPN22 TLR2 TLR4
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 IL6 PTPN22 TLR4 TNF
4 positive regulation of gene expression GO:0010628 9.8 IL6 PTPN22 TLR2 TLR4 TNF
5 immune system process GO:0002376 9.8 HLA-A HLA-B IL2RA PTPN22 TLR2 TLR4
6 cellular response to lipopolysaccharide GO:0071222 9.79 IL6 TLR4 TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 IL6 TLR2 TLR4 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.72 IL6 TLR2 TNF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 IL6 TLR4 TNF
10 response to bacterium GO:0009617 9.65 IL6 TLR4
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR2 TLR4
12 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.64 HLA-A HLA-B
13 positive regulation of interferon-beta production GO:0032728 9.64 TLR2 TLR4
14 negative regulation of interleukin-6 production GO:0032715 9.63 TLR4 TNF
15 positive regulation of interleukin-12 production GO:0032735 9.63 TLR2 TLR4
16 positive regulation of interleukin-10 production GO:0032733 9.62 TLR2 TLR4
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.62 TLR2 TLR4
18 I-kappaB phosphorylation GO:0007252 9.61 TLR2 TLR4
19 positive regulation of interleukin-8 production GO:0032757 9.61 TLR2 TLR4 TNF
20 regulation of cytokine secretion GO:0050707 9.6 TLR2 TLR4
21 negative regulation of lipid storage GO:0010888 9.59 IL6 TNF
22 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.58 HLA-A HLA-B
23 cellular response to lipoteichoic acid GO:0071223 9.58 TLR2 TLR4
24 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.57 TLR4 TNF
25 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.56 IL6 TNF
26 positive regulation of interleukin-6 production GO:0032755 9.56 IL6 TLR2 TLR4 TNF
27 protection from natural killer cell mediated cytotoxicity GO:0042270 9.54 HLA-A HLA-B
28 positive regulation of NF-kappaB import into nucleus GO:0042346 9.54 TLR2 TLR4 TNF
29 immune response GO:0006955 9.5 HLA-A HLA-B IL2RA IL6 TLR2 TLR4
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 PTPN22 TLR2 TLR4 TNF
31 positive regulation of chemokine production GO:0032722 8.92 IL6 TLR2 TLR4 TNF

Molecular functions related to Anterior Uveitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-A HLA-B
2 lipopolysaccharide binding GO:0001530 8.96 TLR2 TLR4
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Anterior Uveitis

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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