MCID: ANT034
MIFTS: 42

Anterior Uveitis malady

Summaries for Anterior Uveitis

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33MalaCards
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MalaCards: Anterior Uveitis, also known as acute anterior uveitis, is related to uveitis and ankylosing spondylitis. An important gene associated with Anterior Uveitis is CXCR1 (chemokine (C-X-C motif) receptor 1), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds (glc)4 and tc 14012 have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and spinal cord.

Aliases & Classifications for Anterior Uveitis

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

anterior uveitis 43
acute anterior uveitis 61
iridocyclitis 43


Related Diseases for Anterior Uveitis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the uveitis family:

infectious anterior uveitis posterior uveitis
intermediate uveitis anterior uveitis

Diseases related to Anterior Uveitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis32.0CXCR1
2ankylosing spondylitis31.0KIR2DL2
3arthritis30.9TLR4, PSMB9, CXCR1, PTPN22
4tuberculosis30.2CX3CL1, CXCR1, TLR4
5vogt-koyanagi-harada disease30.0FASLG, FAS
6vitiligo29.8PTPN22
7autoimmune thyroiditis29.8FAS, FASLG, PSMB9, PTPN22
8systemic lupus erythematosus29.8TLR4, FAS, FASLG, PTPN22
9idiopathic anterior uveitis10.7
10spondylitis10.7
11juvenile rheumatoid arthritis10.6
12n syndrome10.4
13vasculitis10.4
14nephritis10.4
15infectious anterior uveitis10.3
16retinal vasculitis10.3
17posterior uveitis10.3
18rubella10.3
19herpes zoster10.3
20anterior scleritis10.3
21spondyloarthropathy10.3
22syphilis10.3
23klebsiella10.3
24chikungunya10.2
25toxoplasmosis10.2
26choroiditis10.2
27scotoma10.2
28granuloma annulare10.2
29cytomegalovirus retinitis10.2
30mastocytosis10.2
31h. pylori infection10.2
32blindness10.2
33herpes simplex virus keratitis10.2
34endotheliitis10.2
35gonococcal iridocyclitis10.1
36ocular toxoplasmosis10.1
37iritis10.0
38pars planitis10.0
39lens-induced iridocyclitis10.0
40astigmatism10.0
41posner-schlossman syndrome10.0
42graft versus host disease10.0
43crohn's disease10.0
44rift valley fever10.0
45cryoglobulinemia10.0
46relapsing polychondritis10.0
47melkersson-rosenthal syndrome10.0
48posterior scleritis10.0
49cystoid macular edema10.0
50noonan syndrome10.0

Graphical network of the top 20 diseases related to Anterior Uveitis:



Diseases related to anterior uveitis

Clinical Features for Anterior Uveitis

Drugs & Therapeutics for Anterior Uveitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Anterior Uveitis

Drug clinical trials:

Search ClinicalTrials for Anterior Uveitis

Search NIH Clinical Center for Anterior Uveitis

Search CenterWatch for Anterior Uveitis

Genetic Tests for Anterior Uveitis

Anatomical Context for Anterior Uveitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Anterior Uveitis:

33
Skin, Tongue, Spinal cord, Kidney, Lymph node, Lung, Thyroid, Breast, Prostate, T cells, B cells, Endothelial

Animal Models for Anterior Uveitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Anterior Uveitis

Sources:
51PubMed
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Articles related to Anterior Uveitis:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Factors Predictive of Remission of New-Onset Anterior Uveitis. (24342020)
2013
2
The diagnostic utility of anterior chamber paracentesis for polymerase chain reaction in anterior uveitis. (24053895)
2013
3
HLA-B60 and the HLA-B27/HLA-B60 genotype are not risk factors for acute anterior uveitis. (24257027)
2013
4
Severe bilateral anterior uveitis secondary to giardiasis, initially misdiagnosed as a side effect of metronidazole. (23827978)
2013
5
Copy number variations of complement component C4 are associated with BehAset's disease but not with ankylosing spondylitis associated with acute anterior uveitis. (23918728)
2013
6
Unilateral intraocular mastocytosis and anterior uveitis in a dog with subcutaneous mast cell tumors. (23578200)
2013
7
Association of cytomegalovirus with idiopathic chronic anterior uveitis with ocular hypertension in Korean patients. (23480606)
2013
8
Findings in detection of Herpesviridae by polymerase chain reaction and intraocular antibody production in a case series of anterior uveitis. (23323583)
2013
9
Corneal biomechanical properties in patients with recurrent anterior uveitis. (22794524)
2012
10
Lymphoplasmacytic endotheliitis and anterior uveitis in sheep infected experimentally with rift valley fever virus. (21601870)
2012
11
Acute anterior uveitis and optic neuritis as ocular complications of influenza A infection in an 11-year-old boy. (21732577)
2011
12
Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant. (21273539)
2011
13
Cytomegalovirus and herpes simplex virus as causes of bilateral anterior uveitis in an immunocompetent patient. (21292204)
2011
14
Anterior uveitis as an initial manifestation of polymyalgia rheumatica. (21629812)
2011
15
Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre. (20379299)
2010
16
Gender and laterality affect recurrences of acute anterior uveitis. (20733025)
2010
17
High-dose daclizumab for the treatment of juvenile idiopathic arthritis-associated active anterior uveitis. (19664754)
2009
18
Acute conjunctivitis with episcleritis and anterior uveitis linked to adiaspiromycosis and freshwater sponges, Amazon region, Brazil, 2005. (19331759)
2009
19
Investigation of anterior uveitis / L'investigation de l'uvAcite antAcrieure. (19020626)
2008
20
Brimonidine-induced anterior uveitis and conjunctivitis: clinical and histologic features. (18303383)
2008
21
Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis. (18421237)
2008
22
Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. (17389503)
2007
23
Neisseria meningitidis endogenous endophthalmitis presenting as anterior uveitis. (17913177)
2007
24
Diagnostic ophthalmology. Anterior uveal neoplasia and anterior uveitis. (18050804)
2007
25
Intraocular diseases - anterior uveitis. (17264497)
2007
26
Treatment of autoimmune anterior uveitis with recombinant TCR ligands. (16723470)
2006
27
Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept. (16052578)
2005
28
Effects of pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, on cytokine expression and ocular inflammation in experimental autoimmune anterior uveitis. (15857275)
2005
29
Henoch-Schonlein purpura with keratitis and granulomatous anterior uveitis. (16113386)
2005
30
Effects of the NF-kappaB inhibitor pyrrolidine dithiocarbamate on experimentally induced autoimmune anterior uveitis. (15790900)
2005
31
Acute anterior uveitis. (15865688)
2004
32
Bilateral acute anterior uveitis after alendronate. (12446386)
2002
33
Cryptic MBP epitope 1-20 is inducing autoimmune anterior uveitis without EAE in Lewis rats. (12426004)
2002
34
Disturbed expression of Fas/FasL on CD4(+) and CD8(+)T cells in Behcet's disease, Vogt-Koyanagi-Harada syndrome, and idiopathic anterior uveitis. (11815887)
2001
35
Caterpillar setae-induced acute anterior uveitis: a case report. (11124313)
2000
36
Granulomatous anterior uveitis in a patient with CREST syndrome. (11120581)
2000
37
Anterior uveitis in murine relapsing experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). (10611718)
2000
38
Controlled evaluation of loteprednol etabonate and prednisolone acetate in the treatment of acute anterior uveitis. Loteprednol Etabonate US Uveitis Study Group. (10334346)
1999
39
pANCA antibodies in patients with anterior uveitis: identification of a marker antibody usually associated with ulcerative colitis. (9710743)
1998
40
Acute anterior uveitis in a child with HLA-B60 after Salmonella enteritis associated with the transient appearance of auto-antibody. (8741325)
1996
41
Adenoma of nonpigmented epithelium of the ciliary body presenting as anterior uveitis and glaucoma: a case report. (8822491)
1995
42
Bowel inflammation in anterior uveitis and spondyloarthropathy. (7674239)
1995
43
Bilateral anterior uveitis: a feature of streptokinase-induced serum sickness. (8302336)
1994
44
Experimental autoimmune anterior uveitis. The preparation of uveitogenic ocular melanin. (8449688)
1993
45
A spectrum of clinical signs in anterior uveitis. (8325427)
1993
46
Clinical laboratory testing for the diagnosis of systemic disease associated with anterior uveitis. (1576439)
1992
47
Anterior uveitis and hypopyon. (1882942)
1991
48
The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. (1869411)
1991
49
Yersinia infection in acute anterior uveitis. (2244823)
1990
50
Mycoplasmal anterior and posterior uveitis. I. Clinical manifestations of the experimental disease. (5796098)
1969

Genetic Variations for Anterior Uveitis

Expression for genes affiliated with Anterior Uveitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anterior Uveitis

Search GEO for disease gene expression data for Anterior Uveitis.

Pathways for genes affiliated with Anterior Uveitis

Sources:
54Reactome, 52QIAGEN, 30KEGG, 53R&D Systems, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3FASLG, FAS
210.3FASLG, FAS
3
Immune response Bacterial infections in normal airways
10.2TLR4, FAS, FASLG
4
Hide members
10.2FASLG, FAS, TLR4
510.2CX3CL1, CXCR1, CCR2
610.2CX3CL1, TLR4, CCR2
710.1CCR2, FAS, FASLG, PTPN22
8
Hide members
10.0CCR2, TLR4, FAS, FASLG, CXCR1, CX3CL1
9
Hide members
10.0KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DS1
10
Hide members
9.9KIR2DS2, KIR3DS1, KIR2DS1, KIR2DS4, KIR2DS5
11
Hide members
9.6KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR3DS1, KIR2DS1
12
Hide members
9.5KIR2DS4, KIR2DS1, KIR2DS2, KIR2DL2, KIR2DS3, KIR2DL5A
13
Hide members
9.4KIR2DS5, FAS, FASLG, KIR2DS4, KIR2DS1, KIR2DS2

Compounds for genes affiliated with Anterior Uveitis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 11DrugBank
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Compounds related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1(glc)44510.6FASLG, FAS
2tc 140126010.6CCR2, CXCR1
3sb 22500260 2911.5CCR2, CXCR1
4sb 2656106010.5CCR2, CXCR1
5ifn-alpha4510.5TLR4, FAS, FASLG
6c2ceramide4510.5FASLG, FAS, TLR4
7rs 5043936010.5CCR2, CXCR1
8atpo45 2911.4FAS, FASLG
9rantes4510.4TLR4, FAS, FASLG, CXCR1
10maraviroc45 60 50 29 1114.3CCR2, CXCR1
11teniposide45 1111.3FASLG, FAS
12wortmannin4510.1CXCR1, FASLG, FAS, TLR4
13cysteine4510.0TLR4, FAS, FASLG, CXCR1, CX3CL1, KIR2DS4
14tyrosine459.9PTPN22, TLR4, FAS, FASLG, CXCR1, KIR2DL3
15actinomycin d459.9TLR4, FAS, FASLG, CXCR1

GO Terms for genes affiliated with Anterior Uveitis

Sources:
16Gene Ontology
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Cellular components related to Anterior Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.6TLR4, FASLG, KIR2DL3, KIR2DL1, KIR2DS3, KIR3DS1
2plasma membraneGO:0058868.8KIR2DS5, CCR2, TLR4, FAS, CXCR1, CX3CL1

Biological processes related to Anterior Uveitis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.4FASLG, FAS
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.3FAS, FASLG
3positive regulation of inflammatory responseGO:05072910.3CCR2, TLR4, CX3CL1
4positive regulation of tumor necrosis factor biosynthetic processGO:04253510.2CCR2, TLR4
5chemotaxisGO:00693510.2CX3CL1, CXCR1, CCR2
6regulation of immune responseGO:05077610.1KIR2DL3, KIR2DL1, KIR2DL2, KIR2DS2, KIR2DS1
7dendritic cell chemotaxisGO:00240710.0CXCR1, CCR2
8innate immune responseGO:0450879.9CCR2, TLR4, KIR2DS2, KIR3DS1, KIR2DS1, KIR2DS4
9immune responseGO:0069559.7KIR2DS5, CCR2, TLR4, FASLG, CX3CL1, KIR2DL3

Molecular functions related to Anterior Uveitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.3CXCR1, CCR2
2transmembrane signaling receptor activityGO:00488810.0KIR2DS1, KIR2DS2, FAS, TLR4
3receptor activityGO:0048729.8TLR4, FAS, KIR2DL3, KIR2DL1

Products for genes affiliated with Anterior Uveitis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Anterior Uveitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet