MCID: ANT018
MIFTS: 39

Anthracosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Anthracosis

MalaCards integrated aliases for Anthracosis:

Name: Anthracosis 12 41 14 69
Coal Workers' Pneumoconiosis 12 72
Pneumoconiosis 49 69
Black Lung 12 3
Coal Worker's Pneumoconiosis 49
Coal Miner's Pneumoconiosis 12
Coal Workers Pneumoconiosis 51
Coal Workers' Lung 12
Black Lung Disease 49
Melanoedema 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10327
ICD10 32 J60
ICD9CM 34 500
MeSH 41 D055008
NCIt 46 C34390
SNOMED-CT 64 155588007 29422001
UMLS 69 C0003165

Summaries for Anthracosis

CDC : 3 The pneumoconioses are a group of interstitial lung diseases caused by the inhalation of certain dusts and the lung tissue’s reaction to the dust. The principal cause of the pneumoconioses is work-place exposure; environmental exposures have rarely given rise to these diseases.

MalaCards based summary : Anthracosis, also known as coal workers' pneumoconiosis, is related to pneumoconiosis and silicosis. An important gene associated with Anthracosis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Lung fibrosis. The drugs Iron and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and prostate.

Wikipedia : 72 Coal workers\' pneumoconiosis (CWP), also known as black lung disease or black lung, is caused by long... more...

Related Diseases for Anthracosis

Diseases related to Anthracosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 pneumoconiosis 34.2 CCL2 TNF
2 silicosis 30.2 CCL2 TNF
3 kaolin pneumoconiosis 12.3
4 pneumoconiosis due to talc 12.2
5 graphite pneumoconiosis 12.1
6 interstitial lung disease 10.9
7 scleritis 10.3 CCL2 TNF
8 stachybotrys chartarum 10.3 CCL2 TNF
9 ischemic heart disease 10.3 CCL2 TNF
10 tuberculous meningitis 10.3 CCL2 TNF
11 stromal keratitis 10.3 CCL2 TNF
12 pleural tuberculosis 10.3 CCL2 TNF
13 viral encephalitis 10.3 CCL2 TNF
14 dengue shock syndrome 10.3 CCL2 TNF
15 mycobacterium tuberculosis 1 10.3
16 extrinsic cardiomyopathy 10.3 CCL2 TNF
17 pleurisy 10.3 CCL2 TNF
18 complex regional pain syndrome 10.3 CCL2 TNF
19 leptospirosis 10.3 CCL2 TNF
20 pyelonephritis 10.3 CCL2 TNF
21 neuritis 10.3 CCL2 TNF
22 severe acute respiratory syndrome 10.3 CCL2 TNF
23 chorioamnionitis 10.2 CCL2 TNF
24 pulmonary sarcoidosis 10.2 CCL2 TNF
25 mediastinitis 10.2
26 alcoholic hepatitis 10.2 CCL2 TNF
27 autoinflammation, lipodystrophy, and dermatosis syndrome 10.2 CCL2 TNF
28 joint disorders 10.2 IL18R1 TNF
29 leukomalacia 10.2 IL18R1 TNF
30 bone inflammation disease 10.2 CCL2 TNF
31 peritonitis 10.2 CCL2 TNF
32 respiratory system disease 10.1 CCL2 TNF
33 smallpox 10.1 IL18R1 TNF
34 overnutrition 10.1 CCL2 TNF
35 esophagitis 10.1
36 pulmonary tuberculosis 10.1
37 lymphadenitis 10.0
38 adenocarcinoma 10.0
39 relapsing-remitting multiple sclerosis 10.0 CCL2 TNF
40 nontuberculous mycobacterial lung disease 10.0 BMP6 TNF
41 localized scleroderma 10.0 BMP6 TNF
42 trypanosomiasis 10.0 CCL2 TNF
43 fasciitis 10.0 BMP6 TNF
44 rasmussen encephalitis 9.9 BMP6 TNF
45 lung cancer 9.9
46 prostatitis 9.9
47 dry eye syndrome 9.9 BMP6 TNF
48 urinary system disease 9.8 CCL2 TNF
49 renal fibrosis 9.8 BMP6 CCL2
50 small cell cancer of the lung 9.7

Comorbidity relations with Anthracosis via Phenotypic Disease Network (PDN): (show all 14)


Bronchitis Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Pneumoconiosis Postinflammatory Pulmonary Fibrosis
Prostate Cancer Prostatic Hypertrophy
Respiratory Failure Silicosis

Graphical network of the top 20 diseases related to Anthracosis:



Diseases related to Anthracosis

Symptoms & Phenotypes for Anthracosis

Drugs & Therapeutics for Anthracosis

Drugs for Anthracosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2 Liver Extracts Phase 4
3 Micronutrients Phase 4
4 Trace Elements Phase 4
5
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
6
Metoprolol Approved, Investigational Phase 2, Phase 3 51384-51-1, 37350-58-6 4171
7
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
8
Rifampin Approved Phase 3 13292-46-1 5381226 5458213
9
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
10 Adrenergic Agents Phase 2, Phase 3
11 Adrenergic Antagonists Phase 2, Phase 3
12 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
13 Adrenergic beta-Antagonists Phase 2, Phase 3
14 Anti-Arrhythmia Agents Phase 2, Phase 3
15 Antihypertensive Agents Phase 2, Phase 3
16 Autonomic Agents Phase 2, Phase 3
17 calcium channel blockers Phase 2, Phase 3
18 Calcium, Dietary Phase 2, Phase 3
19 Neurotransmitter Agents Phase 2, Phase 3
20 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
21 Sympatholytics Phase 2, Phase 3
22 Vasodilator Agents Phase 2, Phase 3
23 Anti-Bacterial Agents Phase 3
24 Antibiotics, Antitubercular Phase 3
25 Anti-Infective Agents Phase 3
26 Antimetabolites Phase 3
27 Antitubercular Agents Phase 3
28 Cytochrome P-450 CYP3A Inducers Phase 3
29 Hypolipidemic Agents Phase 3
30 Lipid Regulating Agents Phase 3
31 Nucleic Acid Synthesis Inhibitors Phase 3
32
Infliximab Approved Phase 1, Phase 2 170277-31-3
33 Mitogens Phase 1, Phase 2
34 Analgesics Phase 1, Phase 2
35 Analgesics, Non-Narcotic Phase 1, Phase 2
36 Anti-Inflammatory Agents Phase 1, Phase 2
37 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
38 Antirheumatic Agents Phase 1, Phase 2
39 Mesalamine Phase 1, Phase 2 89-57-6
40 Dermatologic Agents Phase 1, Phase 2
41 Gastrointestinal Agents Phase 1, Phase 2
42
Deferiprone Approved 30652-11-0 2972
43
Heparin Approved, Investigational 9005-49-6 46507594 772
44 Respiratory System Agents Not Applicable
45 Chelating Agents
46 Iron Chelating Agents
47 calcium heparin
48 Pharmaceutical Solutions
49 Xenon Early Phase 1

Interventional clinical trials:

(show all 26)

# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
3 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3 Weekly INH / RRT given by DOT
4 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
5 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
6 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
7 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
8 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
9 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Not yet recruiting NCT02790762 Phase 1
10 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343 Not Applicable
11 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
12 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
13 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
14 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280 Not Applicable
15 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
16 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
17 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224 Not Applicable
18 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
19 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989 Not Applicable
20 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
21 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Recruiting NCT02794701
22 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
23 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
24 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
25 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Not yet recruiting NCT03464344 Not Applicable
26 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Anthracosis

Cochrane evidence based reviews: anthracosis

Genetic Tests for Anthracosis

Anatomical Context for Anthracosis

MalaCards organs/tissues related to Anthracosis:

38
Lung, Lymph Node, Prostate, Bone, Liver, Bone Marrow

Publications for Anthracosis

Articles related to Anthracosis:

(show top 50) (show all 211)
# Title Authors Year
1
Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269. ( 29415464 )
2018
2
A response to the Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269 by the Author Mei Yong. ( 29438277 )
2018
3
Association analysis identifies new risk loci for coal workers' pneumoconiosis in Han Chinese men. ( 29394417 )
2018
4
Estimated economic costs of coal workers' pneumoconiosis among coal workers redeployed from the Fuxin mining group in China. ( 29116190 )
2018
5
TNFR/TNF-I+ signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis. ( 29416696 )
2018
6
A potential pitfall in the use of (68)Ga-PSMA PET/CT: Anthracosis. ( 27666999 )
2017
7
The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis. ( 28444932 )
2017
8
Multi-Gene Expression in Anthracosis of the Lungs as One of the Risk Factors for Non-Small Cell Lung Cancer ( 29172290 )
2017
9
Diagnostic and clinical application value of magnetic resonance imaging (MRI) for progressive massive fibrosis of coal worker pneumoconiosis: Case reports. ( 28514304 )
2017
10
Cross-section analysis of coal workers' pneumoconiosis and higher brachial-ankle pulse wave velocity within Kailuan study. ( 28148238 )
2017
11
LRBA Gene Polymorphisms and Risk of Coal Workers' Pneumoconiosis: A Case-Control Study from China. ( 28953250 )
2017
12
Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population. ( 28844669 )
2017
13
Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. ( 28272360 )
2017
14
Survival Analysis of Coal Workers' Pneumoconiosis (CWP) Patients in a State-Owned Mine in the East of China from 1963 to 2014. ( 28481235 )
2017
15
Anthracosis with a Mosaic Attenuation Pattern. ( 29279499 )
2017
16
Platelet Indices in Patients with Coal Workers' Pneumoconiosis. ( 27107875 )
2016
17
Lung transplantation is increasingly common among patients with coal workers' pneumoconiosis. ( 26725917 )
2016
18
Plasma LncRNA-ATB, a Potential Biomarker for Diagnosis of Patients with Coal Workers' Pneumoconiosis: A Case-Control Study. ( 27556453 )
2016
19
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. ( 26977968 )
2016
20
Screening and Preliminary Verification of a Phage Display Single-Chain Antibody Library Against Coal Workers' Pneumoconiosis. ( 27930489 )
2016
21
Inguinal Lymph Node Anthracosis: A Case Report. ( 27536493 )
2016
22
Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population. ( 27626436 )
2016
23
Estimates and Predictions of Coal Workers' Pneumoconiosis Cases among Redeployed Coal Workers of the Fuxin Mining Industry Group in China: A Historical Cohort Study. ( 26845337 )
2016
24
Pulmonary anthracosis mimicking lung metastases in pediatric rhabdomyosarcoma. ( 27592612 )
2016
25
Re: Anthracosis Mimicking Mediastinal Lymph Node Metastases With 18F-FCholine in High-Risk Prostate Cancer. ( 27749414 )
2016
26
Coal workers' pneumoconiosis: an Australian perspective. ( 27318401 )
2016
27
Endobronchial anthracosis with concurrent primary lung cancer. ( 26917802 )
2016
28
Clinico-radiological profile and risk factors in patients with anthracosis. ( 25814792 )
2015
29
Associations of MMP-7 and OPN gene polymorphisms with risk of coal workers' pneumoconiosis in a Chinese population: a case-control study. ( 26330178 )
2015
30
A fire death with a rare finding: anthracosis or soot embolism? ( 25890616 )
2015
31
CT differentiation of enlarged mediastinal lymph node due to anthracosis from metastatic lymphadenopathy: a comparative study proven by endobronchial US-guided transbronchial needle aspiration. ( 25616268 )
2015
32
Anthracosis: An unusual cause of vocal fold paralysis. ( 26214668 )
2015
33
Comparison of the Cumulative Incidence Rates of Coal Workers' Pneumoconiosis between 1970 and 2013 among Four State-Owned Colliery Groups in China. ( 26133134 )
2015
34
Percutaneous treatment for pulmonary hypertension caused by pulmonary artery stenosis due to anthracosis. ( 25946371 )
2015
35
Prevalence Characteristics of Coal Workers' Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China. ( 26184259 )
2015
36
Cost-Effectiveness of Coal Workers' Pneumoconiosis Prevention Based on Its Predicted Incidence within the Datong Coal Mine Group in China. ( 26098706 )
2015
37
Serum levels of IL-8 and ICAM-1 as biomarkers for progressive massive fibrosis in coal workers' pneumoconiosis. ( 25653483 )
2015
38
Comparison of samples obtained from bronchoscopy of patients with and without bronchial anthracosis for investigating the prevalence of Mycobacterium tuberculosis. ( 26405675 )
2015
39
Polymorphisms in interleukin 17A gene and coal workers' pneumoconiosis risk in a Chinese population. ( 26223249 )
2015
40
Associations of MMP1, MMP2 and MMP3 Genes Polymorphism with Coal Workers' Pneumoconiosis in Chinese Han Population. ( 26528997 )
2015
41
Risk factors and maximum standardized uptake values within lymph nodes of anthracosis diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration. ( 26422878 )
2015
42
Anthracosis mimicking mediastinal lymph node metastases with 18F-FCholine in high-risk prostate cancer. ( 25674859 )
2015
43
Esophageal anthracosis with tuberculous lymphadenitis confirmed on transesophageal endoscopic ultrasound-guided fine-needle aspiration. ( 24633027 )
2014
44
MUC5B promoter polymorphisms and risk of coal workers' pneumoconiosis in a Chinese population. ( 24924948 )
2014
45
Chest CT Findings in EBUS-TBNA-Proven Anthracosis inA Enlarged Mediastinal Lymph Nodes. ( 24955645 )
2014
46
Serum levels of TGF-I^1 and MCP-1 as biomarkers for progressive coal workers' pneumoconiosis in retired coal workers: a three-year follow-up study. ( 24464026 )
2014
47
Polymorphisms in cyclooxygenase-2 gene and risk of developing coal workers' pneumoconiosis: a case-control study. ( 24899082 )
2014
48
Indoor smoke exposure and risk of anthracosis. ( 25429181 )
2014
49
Anthracosis in a Coptic mummy. ( 24684766 )
2014
50
Anthracosis of the lungs: etiology, clinical manifestations and diagnosis: a review. ( 25852756 )
2014

Variations for Anthracosis

Expression for Anthracosis

Search GEO for disease gene expression data for Anthracosis.

Pathways for Anthracosis

GO Terms for Anthracosis

Biological processes related to Anthracosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.65 BMP6 CCL2 TNF
2 cellular response to organic cyclic compound GO:0071407 9.49 CCL2 TNF
3 response to glucocorticoid GO:0051384 9.46 BMP6 TNF
4 positive regulation of epithelial cell proliferation GO:0050679 9.43 BMP6 LAMB1
5 humoral immune response GO:0006959 9.4 CCL2 TNF
6 protein kinase B signaling GO:0043491 9.37 CCL2 TNF
7 positive regulation of interferon-gamma production GO:0032729 9.32 IL18R1 TNF
8 negative regulation of viral genome replication GO:0045071 9.26 BANF1 TNF
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.16 CCL2 TNF
10 positive regulation of NF-kappaB import into nucleus GO:0042346 8.96 IL18R1 TNF
11 immune response GO:0006955 8.92 BMP6 CCL2 IL18R1 TNF

Molecular functions related to Anthracosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 BMP6 CCL2 TNF

Sources for Anthracosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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