APS
MCID: ANT006
MIFTS: 56

Antiphospholipid Syndrome (APS) malady

Categories: Rare diseases, Immune diseases, Genetic diseases

Aliases & Classifications for Antiphospholipid Syndrome

Aliases & Descriptions for Antiphospholipid Syndrome:

Name: Antiphospholipid Syndrome 12 50 25 51 52 42 14 69
Antiphospholipid Antibody Syndrome 12 50 25
Hughes Syndrome 50 25 51
Familial Antiphospholipid Syndrome 50 69
Acromegaloid Facial Appearance Syndrome 69
Lupus Anticoagulant, Familial 50
Anti-Phospholipid Syndrome 25
Aps 50

Classifications:



External Ids:

Disease Ontology 12 DOID:2988
ICD10 33 D68.61
MeSH 42 D016736
NCIt 47 C61283
UMLS 69 C0085278

Summaries for Antiphospholipid Syndrome

NINDS : 51 Antiphospholipid syndrome (APS) is an autoimmune disorder caused when antibodies -- immune system cells that fight off bacteria and viruses -- mistakenly attack healthy body tissues and organs.  In APS, specific antibodies activate the inner lining of blood vessels, which leads to the formation of blood clots in arteries or veins.  APS is sometimes called “sticky blood syndrome,” because of the increased tendency to form blood clots in the veins and arteries.  The symptoms of APS are due to the abnormal blood clotting.  Clots can develop in the veins of the legs and lungs, or in the placenta of pregnant women.  One of the most serious complications of APS occurs when a clot forms in the brain and causes a stroke.  Other neurological symptoms include chronic headaches, dementia (similar to the dementia of Alzheimer’s disease), and seizures.  Infrequently, individuals will develop chorea (a movement disorder in which the body and limbs writhe uncontrollably), cognitive dysfunction (such as poor memory), transverse myelitis, depression or psychosis, optic neuropathy, or sudden hearing loss.  In pregnant women, clots in the placenta can cause miscarriages.  APS is diagnosed by the presence of a positive antiphospholipid antibody and either a history of blood clots in an artery or vein or a history of multiple miscarriages or other pregnancy problems.  Some individuals will have a characteristic lacy, net-like red rash called livedo reticularis over their wrists and knees. 

MalaCards based summary : Antiphospholipid Syndrome, also known as antiphospholipid antibody syndrome, is related to lupus erythematosus and endocarditis, and has symptoms including blurred vision and unspecified visual loss. An important gene associated with Antiphospholipid Syndrome is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Dalteparin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, placenta and lung, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A hypersensitivity reaction type II disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).

Genetics Home Reference : 25 Antiphospholipid syndrome is a disorder characterized by an increased tendency to form abnormal blood clots (thromboses) that can block blood vessels. This clotting tendency is known as thrombophilia. In antiphospholipid syndrome, the thromboses can develop in nearly any blood vessel in the body, but most frequently occur in the vessels of the lower limbs. If a blood clot forms in the vessels in the brain, blood flow is impaired and can lead to stroke. Antiphospholipid syndrome is an autoimmune disorder. Autoimmune disorders occur when the immune system attacks the body's own tissues and organs.

NIH Rare Diseases : 50 antiphospholipid syndrome (aps) is an autoimmune disorder. signs and symptoms vary, but may include blood clots, miscarriage, rash, chronic headaches, dementia, and seizures. aps occurs when your body's immune system makes antibodies that attack phospholipids. phospholipids are a type of fat found in all living cells, including blood cells and the lining of blood vessels. most cases of aps occur in people with no family history of the disorder, however there are rare cases of aps clustering in a family. a widely accepted explanation for aps is that it is caused by a combination of gene mutations (making one more susceptible to aps) and an environmental exposure (such as to a virus). currently there is not a cure for aps. the goal of treatment is to prevent blood clots from forming and to keep existing clots from getting larger. last updated: 5/25/2016

Wikipedia : 71 Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune,... more...

Related Diseases for Antiphospholipid Syndrome

Diseases in the Antiphospholipid Syndrome family:

Antiphospholipid Syndrome, Familial

Diseases related to Antiphospholipid Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 428)
id Related Disease Score Top Affiliating Genes
1 lupus erythematosus 30.5 F3 PLAT SELP SERPINC1
2 endocarditis 29.9 CD40LG CD79A
3 ischemic optic neuropathy 29.4 APOH F2 SELP SERPINC1
4 cysticercosis 29.4 CD40LG SERPINC1
5 influenza 29.3 F2 F3 SERPINC1
6 artery disease 29.3 CD40LG CD79A F2 F3
7 central retinal artery occlusion 29.1 APOH CD40LG F2 F3 MTHFR SERPINC1
8 budd-chiari syndrome 28.6 APOH F2 F3 F5 MTHFR PLAT
9 myeloproliferative neoplasm 28.5 ADAMTS13 CD40LG F10 F2 F3 SELP
10 myocardial infarction 28.1 ADAMTS13 ANXA5 F10 F2 F3 F5
11 catastrophic antiphospholipid syndrome 12.3
12 antiphospholipid syndrome, familial 12.1
13 neonatal antiphospholipid syndrome 11.9
14 x-linked intellectual disability-hypogonadism-ichthyosis-obesity-short stature syndrome 10.9
15 thrombosis 10.4
16 systemic lupus erythematosus 10.4
17 med13l syndrome 10.4 APOH F5
18 congenital insensitivity to pain with severe intellectual disability 10.3 F2 F5
19 achard thiers syndrome 10.3 APOH F5
20 hemarthrosis 10.3 F2 F3
21 multiple familial trichoepithelioma 10.3 F5 MTHFR
22 absence of innominate vein 10.3 F5 MTHFR
23 scn8a-related epilepsy with encephalopathy 10.3 F2 MTHFR
24 myeloid leukemia 10.3 APOH CD40LG
25 exhibitionism 10.3 APOH CD40LG
26 aminoaciduria 10.3 F5 MTHFR
27 acrodysplasia with ossification abnormalities, short stature and fibular hypoplasia 10.3 F3 F5
28 intermediate coronary syndrome 10.3 APOH CD40LG
29 alpha-2-macroglobulin deficiency 10.3 F2 F3
30 porphyria 10.3 F2 MTHFR
31 sporotrichosis 10.3 CD40LG F2 F3
32 chronic inflammatory demyelinating polyneuritis 10.3 CD40LG F2 F3
33 lung combined large cell neuroendocrine carcinoma 10.3 APOH CD40LG F3
34 stroke, ischemic 10.3 F2 F3 F5
35 fletcher factor deficiency 10.3 F2 F3 F5
36 lung cancer 10.3 APOH F5 MTHFR
37 depressed scar 10.3 CD40LG F2 F3
38 low anorectal malformation 10.2 F2 F3 F5
39 photosensitive epilepsy 10.2 F2 F5 MTHFR
40 houlston ironton temple syndrome 10.2 F2 F5 MTHFR
41 villous adenoma 10.2 F2 F5 MTHFR
42 prostatic hypertrophy 10.2 F2 F3 SELP
43 childhood type dermatomyositis 10.2 F2 F5 MTHFR
44 mucolipidoses 10.2 CD40LG PLAT
45 vcl-related dilated cardiomyopathy 10.2 ADAMTS13 SELP
46 pyridoxamine 5'-phosphate oxidase deficiency 10.2 F2 F3 SELP
47 acrodysplasia scoliosis 10.2 F10 F3 F5
48 immunodeficiency 32a, mycobacteriosis, autosomal dominant 10.2 PLAT THBD
49 hendra virus infection 10.2 APOH F2 F3 F5
50 metaphyseal chondrodysplasia with cone-shaped epiphyses, normal hair, and normal hands 10.2 PLAT THBD

Graphical network of the top 20 diseases related to Antiphospholipid Syndrome:



Diseases related to Antiphospholipid Syndrome

Symptoms & Phenotypes for Antiphospholipid Syndrome

UMLS symptoms related to Antiphospholipid Syndrome:


blurred vision, unspecified visual loss

MGI Mouse Phenotypes related to Antiphospholipid Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ADAMTS13 APOH CD40LG CD79A F10 F2
2 hematopoietic system MP:0005397 10.17 ADAMTS13 ANXA5 CD40LG CD79A F2 F3
3 cardiovascular system MP:0005385 10.16 F2 F3 F5 PLAT SELE CD40LG
4 immune system MP:0005387 10.11 ADAMTS13 ANXA5 CD40LG CD79A F2 F3
5 mortality/aging MP:0010768 9.97 SELE SELP SERPINC1 THBD ADAMTS13 APOH
6 integument MP:0010771 9.92 CD40LG F2 F3 F5 MTHFR SELE
7 liver/biliary system MP:0005370 9.73 CD79A F5 SELE SELP SERPINC1 THBD
8 nervous system MP:0003631 9.65 SERPINC1 THBD CD40LG CD79A F2 F3
9 vision/eye MP:0005391 9.17 ADAMTS13 F3 MTHFR PLAT SELE SELP

Drugs & Therapeutics for Antiphospholipid Syndrome

Drugs for Antiphospholipid Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 103)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4,Phase 2,Early Phase 1 9041-08-1
2
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 9005-49-6 772 46507594
3
Acetaminophen Approved Phase 4,Phase 1 103-90-2 1983
4
Warfarin Approved Phase 4,Phase 3 81-81-2 6691 54678486
5
Apixaban Approved Phase 4 503612-47-3 10182969
6
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
9 Vaccines Phase 4,Phase 1
10 calcium heparin Phase 4,Phase 1,Phase 2,Early Phase 1
11 Heparin, Low-Molecular-Weight Phase 4,Phase 2,Early Phase 1
12 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
13 Antibodies, Antiphospholipid Phase 4,Phase 3,Phase 2
14 Anticoagulants Phase 4,Phase 3,Phase 2,Early Phase 1
15 Fibrinolytic Agents Phase 4,Phase 2,Early Phase 1
16 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
17 Hematinics Phase 4
18 Micronutrients Phase 4
19 Trace Elements Phase 4
20 Vitamin B Complex Phase 4
21 Vitamins Phase 4
22 Analgesics Phase 4,Phase 2,Early Phase 1
23 Analgesics, Non-Narcotic Phase 4,Phase 2,Early Phase 1
24 Antipyretics Phase 4,Phase 2,Early Phase 1
25 Peripheral Nervous System Agents Phase 4,Phase 2,Early Phase 1
26 Antithrombin III Phase 4,Phase 3
27 Antithrombins Phase 4,Phase 3
28 Factor Xa Inhibitors Phase 4,Phase 3
29 HIV Protease Inhibitors Phase 4,Phase 3
30
protease inhibitors Phase 4,Phase 3
31 Serine Proteinase Inhibitors Phase 4,Phase 3
32 Folate Nutraceutical Phase 4
33 Vitamin B9 Nutraceutical Phase 4
34 serine Nutraceutical Phase 4,Phase 3
35
Hydroxychloroquine Approved Phase 3,Phase 2 118-42-3 3652
36
Acenocoumarol Approved Phase 3 152-72-7 9052 54676537
37 Autoantibodies Phase 3,Phase 1
38 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
39 Anti-Infective Agents Phase 3,Phase 2
40 Antimalarials Phase 3,Phase 2
41 Antiparasitic Agents Phase 3,Phase 2
42 Antiprotozoal Agents Phase 3,Phase 2
43
Fluvastatin Approved Phase 2 93957-54-1 1548972
44
Aspirin Approved, Vet_approved Phase 1, Phase 2, Early Phase 1 50-78-2 2244
45
rituximab Approved Phase 2 174722-31-7 10201696
46
Certolizumab pegol Approved Phase 2 428863-50-7
47 Anticholesteremic Agents Phase 2
48 Antimetabolites Phase 2
49 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
50 Hypolipidemic Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 59)
id Name Status NCT ID Phase
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Timing of Initiation of LMWH Administration in Pregnant Women With APS Completed NCT02326051 Phase 4
3 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4
4 Drug Interaction Between Paracetamol and Warfarin Completed NCT01104337 Phase 4
5 Apixaban for the Secondary Prevention of Thromboembolism Among Patients With the AntiphosPholipid Syndrome Recruiting NCT02295475 Phase 4
6 Rivaroxaban for Antiphospholipid Antibody Syndrome Recruiting NCT02116036 Phase 4
7 Use of Warfarin After the First Trimester in Pregnant Women With APS Recruiting NCT02303171 Phase 4
8 Rivaroxaban in Thrombotic Antiphospholipid Syndrome Recruiting NCT02157272 Phase 3
9 Evaluation of the Duration of Therapy for Thrombosis in Children Recruiting NCT00687882 Phase 3
10 Rivaroxaban for Patients With Antiphospholipid Syndrome Active, not recruiting NCT02926170 Phase 3
11 Hydroxychloroquine for Prevention of Recurrent Miscarriage. Not yet recruiting NCT03165136 Phase 3
12 Hydroxychloroquine for the First Thrombosis Prevention in Antiphospholipid Antibody Positive Patients Terminated NCT01784523 Phase 3
13 Effects of Fluvastatin on Proinflammatory and Prothrombotic Markers in Antiphospholipid Syndrome Patients Unknown status NCT00674297 Phase 2
14 Steroids and Antiphospholipid Syndrome- Related Pregnancy Loss Unknown status NCT00180778 Phase 1, Phase 2
15 A Pilot Study of Rituximab for the Anticoagulation Resistant Manifestations of Antiphospholipid Syndrome Completed NCT00537290 Phase 2
16 Low-molecular-weight Heparin (LMWH) Versus Unfractionated Heparin (UFH) in Pregnant Women With Recurrent Abortion Secondary to Antiphospholipid Syndrome Completed NCT01051778 Phase 2
17 Phase IIa Trial of ALXN1007 for the Treatment of Non-criteria Manifestations of Antiphospholipid Syndrome Completed NCT02128269 Phase 2
18 Aspirin in Asymmetrically Intrauterine Growth Completed NCT03038607 Phase 2
19 Study of the Efficiency of Hydroxychloroquine on the Endothelial Dysfunction and Its Vascular Consequences During the Antiphospholipid Syndrome Recruiting NCT02595346 Phase 2
20 IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy Recruiting NCT03152058 Phase 2
21 Eculizumab to Enable Renal Transplantation in Patients With History of Catastrophic Antiphospholipid Antibody Syndrome Active, not recruiting NCT01029587 Phase 2
22 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
23 Safety and Immunogenicity of a Vaccine Dendritic Cell-based Pulsed With Autologous Heat-inactivated in HIV-1 Infected Patients Recruiting NCT02767193 Phase 1
24 Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases Terminated NCT00849745 Phase 1
25 Hematopoietic Stem Cell Transplantation in Patients With Antiphospholipid Syndrome Withdrawn NCT00278616 Phase 1
26 Preconceptional Thromboprophylaxis in Recurrent PREGNANCY LOSSES Caused by Antiphospholipid Syndrome Unknown status NCT01661439
27 Antiphospholipid Antibodies and Early Severe Preeclampsia. Unknown status NCT01538121
28 Antiphospholipid Antibodies and Fetal Growth Restriction Unknown status NCT01538134
29 Longitudinal Study of the Clinical and Haematological Cause of Women With Antiphospholipid Antibodies. Unknown status NCT00180817
30 The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome Unknown status NCT01818505
31 Beneficial Effects of Coenzyme Q10 Treatment on the Mitochondrial Dysfunction and Oxidative Stress Associated to Atherothrombosis Developement in Antiphospholipidid Syndrome Patients Unknown status NCT02218476
32 Monitoring Anticoagulant Therapy in Antiphospholipid Syndrome Completed NCT01660061
33 Antiphospholipid Syndrome Collaborative Registry (APSCORE) Completed NCT00076713
34 Reliability of Point-of-care INR Measurements in Patients With Antiphospholipid-antibody Syndrome Treated With Warfarin Completed NCT00878137
35 The Prognostic Value of PGF and sFlt1 Variations Induced by the First Low-molecular-weight-heparin Injections in Women With Obstetrical Antiphospholipids Antibody Syndrome Starting a New Pregnancy and Following Treatment in Accordance With International R Completed NCT02855047
36 CoaguChek XS in Antiphospholipid Antibody Syndrome (APL) Patients Completed NCT02139072
37 Assessment of the Prevalence of Major Psychiatric Disorders in a Cohort of Women With Clinical Criteria Corresponding to Pure, Abortive-form, Obstetrical, Antiphospholipid Syndrome Completed NCT02833194
38 Pilot Study of Cyclophosphamide in Patients With Life-Threatening Systemic Lupus Erythematosus or Antiphospholipid Antibody Syndrome Completed NCT00010400
39 Hypercoagulable Phenotype by Thrombinography (in Presence of C Protein Dynamic Inhibitory System) Completed NCT02892565
40 CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen Completed NCT01762891
41 Effect of HCQ on AnxA5 Resistance Assay in Antiphospholipid (aPL) Positive Patients With and Without Systemic Lupus Erythematosus (SLE) Completed NCT01475149
42 Pharmacokinetics of Low Molecular Weight and Unfractionated Heparin in Pregnancy Completed NCT00721591
43 Clinical Significance of Antiphospholipid Antibodies in Healthy Subjects Completed NCT02803645
44 Pharmacogenetics of Warfarin in Puerto Ricans. Completed NCT01318057
45 Extra Corporeal Membrane Oxygenation in the Acute Respiratory Distress Syndrome: Utility of a Biomarker to Assess the Membrane Efficiency in Improving Oxygenation Completed NCT02879344
46 Walking and Dietary Modification for Recurrent Early Miscarriages Completed NCT03023137
47 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
48 Observational Study in UTERO - Placental 3D Doppler Examination: Interest for Pre-eclampsia Screening During Pregnancy Completed NCT00930397
49 Register for Pediatric Patients With Antiphospholipid Syndrome (APS): European Project Extended Internationally Study Recruiting NCT00616317
50 Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome Recruiting NCT00482794

Search NIH Clinical Center for Antiphospholipid Syndrome

Cochrane evidence based reviews: antiphospholipid syndrome

Genetic Tests for Antiphospholipid Syndrome

Anatomical Context for Antiphospholipid Syndrome

MalaCards organs/tissues related to Antiphospholipid Syndrome:

39
Brain, Placenta, Lung, Endothelial, Testes, Monocytes, Liver

Publications for Antiphospholipid Syndrome

Articles related to Antiphospholipid Syndrome:

(show top 50) (show all 1404)
id Title Authors Year
1
Dental care in patients with antiphospholipid syndrome: two case reports. ( 28068274 )
2017
2
Diagnostic value of antibodies to phosphatidylserine/prothrombin complex for antiphospholipid syndrome in Chinese patients. ( 28050648 )
2017
3
Cellular immune response to I^2-glycoprotein-I valine/leucine(247) phenotypes in Mexican patients with primary antiphospholipid syndrome. ( 28038927 )
2017
4
Fatal antiphospholipid syndrome following endoscopic transnasal-transsphenoidal surgery for a pituitary tumor: A case report. ( 28072724 )
2017
5
Thrombotic management of antiphospholipid syndrome: Towards novel targeted therapies. ( 28056758 )
2017
6
Atypical bone change of spine caused by epidural venous thrombosis in systemic lupus erythematosus with antiphospholipid syndrome. ( 28063414 )
2017
7
In Vitro Fertilization in 37 Women with Systemic Lupus Erythematosus or Antiphospholipid Syndrome: A Series of 97 Procedures. ( 28089975 )
2017
8
A 37-year-old man with primary antiphospholipid syndrome presenting with respiratory distress and worsening toe ischemia. ( 27992694 )
2016
9
MicroRNA expression in antiphospholipid syndrome: a systematic review and microRNA target genes analysis. ( 28028298 )
2016
10
MACULAR PERIVENOUS RETINAL WHITENING AND PRESUMED RETINO-CILIARY SPARING IN A RECURRENT CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH THE ANTIPHOSPHOLIPID SYNDROME AND CRYOGLOBULINEMIA. ( 27902540 )
2016
11
Clinical implications of the detection of antibodies directed against domain 1 of I^2-glycoprotein 1 in thrombotic antiphospholipid syndrome. ( 27770664 )
2016
12
Takayasu's arteritis and primary antiphospholipid syndrome presenting as hypertensive urgency. ( 26783006 )
2016
13
Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study. ( 27510605 )
2016
14
Pregnancy outcomes of antiphospholipid syndrome: In a low resource South Asian setting. ( 27512499 )
2016
15
Plasma Exchange in the Management of Catastrophic Antiphospholipid Syndrome. ( 27833765 )
2016
16
A Rare Cause of Pulmonary Embolism and Seizure in a Young Man: Antiphospholipid Syndrome. ( 27122957 )
2016
17
Reply to: "Monitoring antivitamin K anticoagulants in antiphospholipid syndrome: A challenge in quality". ( 27993386 )
2016
18
Catastrophic antiphospholipid syndrome (CAPS): Descriptive analysis of 500 patients from the International CAPS Registry. ( 27639837 )
2016
19
Decreased interleukin-35 levels are associated with higher risk of pregnancy morbidity in patients with antiphospholipid syndrome. ( 27086778 )
2016
20
Characteristics of Chinese patients with antiphospholipid syndrome and the ability of lupus anticoagulant assays to identify them. ( 27096780 )
2016
21
Vitamin D deficiency in antiphospholipid syndrome. ( 27994369 )
2016
22
Repeated low-dose courses of rituximab in SLE-associated antiphospholipid syndrome: Data from a tertiary dedicated centre. ( 27639925 )
2016
23
Rivaroxaban limits complement activation compared to warfarin in antiphospholipid syndrome patients with venous thromboembolism. ( 27541499 )
2016
24
The use of direct oral anticoagulants in 56 patients with antiphospholipid syndrome. ( 27989533 )
2016
25
Catastrophic antiphospholipid syndrome in pregnancy, a diagnosis that should not be missed. ( 27023104 )
2016
26
ANNALS EXPRESS: ANTIPHOSPHOLIPID AND ANTIOANGIOGENIC ACTIVITY IN WOMEN WITH RECURRENT MISCARRIAGE AND ANTIPHOSPHOLIPID SYNDROME. ( 27638930 )
2016
27
Systematic review of case reports of antiphospholipid syndrome following infection. ( 27060064 )
2016
28
Ischemic gastrointestinal manifestations in a young adult: Implicating a rare initial presentation of antiphospholipid syndrome. ( 27029604 )
2016
29
Treatment of catastrophic antiphospholipid syndrome. ( 26927441 )
2016
30
Antiphospholipid syndrome: A diagnostic challenge. ( 28050066 )
2016
31
Hepatic infarction in a pregnant woman with antiphospholipid syndrome and triple antibody positivity: A case report focusing on catastrophic antiphospholipid syndrome. ( 27668204 )
2016
32
Cardiac thrombus with risk of fulminant pulmonary embolism in paediatric antiphospholipid syndrome. ( 27138626 )
2016
33
Cutaneous gangrene of the arms and legs after cardiopulmonary resuscitation: A rare presentation of catastrophic antiphospholipid syndrome. ( 27396539 )
2016
34
Immunity and early atherosclerosis in the course of systemic lupus erythematosus, mixed connective tissue disease and antiphospholipid syndrome. ( 27826173 )
2016
35
Gene expression in obstetric antiphospholipid syndrome: a systematic review. ( 28028299 )
2016
36
What is known about pediatric antiphospholipid syndrome? ( 27615277 )
2016
37
Evaluation of the clinical relevance of anti-annexin-A5 antibodies in Chinese patients with antiphospholipid syndrome. ( 28000012 )
2016
38
Complement inhibition by hydroxychloroquine prevents placental and fetal brain abnormalities in antiphospholipid syndrome. ( 27160365 )
2016
39
Lupus anticoagulant-hypoprothrombinemia syndrome and catastrophic antiphospholipid syndrome in a patient with antidomain I antibodies. ( 27380476 )
2016
40
Immunotherapeutic strategies in antiphospholipid syndrome. ( 27572264 )
2016
41
Pregnancy and Antiphospholipid Syndrome. ( 27652601 )
2016
42
Current status and future prospects for the treatment of antiphospholipid syndrome. ( 27117597 )
2016
43
Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208A cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort. ( 27401589 )
2016
44
Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study. ( 27599157 )
2016
45
Pathogenesis of the antiphospholipid syndrome revisited: time to challenge the dogma: comment. ( 27638140 )
2016
46
Antiphospholipid syndrome and kidney disease. ( 27555120 )
2016
47
Catastrophic antiphospholipid syndrome after cardiac surgery. ( 27455170 )
2016
48
Successful Anticoagulation Therapy for Antiphospholipid Syndrome with Mobile Aortic Thrombi. ( 28042559 )
2016
49
Antiphospholipid antibodies detected by line immunoassay differentiate among patients with antiphospholipid syndrome, with infections and asymptomatic carriers. ( 27209064 )
2016
50
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome. ( 27105662 )
2016

Variations for Antiphospholipid Syndrome

Copy number variations for Antiphospholipid Syndrome from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 160790 22 16300000 24300000 Deletion Hughes'' syndrome

Expression for Antiphospholipid Syndrome

Search GEO for disease gene expression data for Antiphospholipid Syndrome.

Pathways for Antiphospholipid Syndrome

Pathways related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 ANXA5 APOH F10 F2 F3 F5
2
Show member pathways
12.46 F10 F2 F3 F5 SERPINC1 THBD
3
Show member pathways
11.92 F2 SELE SELP THBD
4
Show member pathways
11.71 F10 F2 F3 F5 PLAT SERPINC1
5 11.58 F3 SELE THBD
6 11.31 F10 F2 F3 F5 PLAT SERPINC1
7 11.19 CD40LG SELE SELP
8 10.61 F10 F2

GO Terms for Antiphospholipid Syndrome

Cellular components related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 ADAMTS13 APOH CD40LG F3 PLAT THBD
2 endoplasmic reticulum lumen GO:0005788 9.72 ADAMTS13 F10 F2 F5 SERPINC1
3 extracellular region GO:0005576 9.65 ADAMTS13 ANXA5 APOH CD40LG F10 F2
4 external side of plasma membrane GO:0009897 9.55 ANXA5 CD40LG CD79A F2 SELP
5 intrinsic component of external side of plasma membrane GO:0031233 9.37 F10 F3
6 extracellular space GO:0005615 9.36 ADAMTS13 APOH CD40LG F2 F3 F5

Biological processes related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.97 ADAMTS13 F10 F2 F5 PLAT
2 leukocyte migration GO:0050900 9.78 F2 SELE SELP THBD
3 platelet degranulation GO:0002576 9.73 ANXA5 APOH F5 SELP
4 platelet activation GO:0030168 9.71 ADAMTS13 CD40LG F2 F5
5 blood coagulation GO:0007596 9.61 ADAMTS13 ANXA5 F10 F2 F3 F5
6 fibrinolysis GO:0042730 9.58 F2 PLAT
7 signal peptide processing GO:0006465 9.58 F10 F2
8 leukocyte tethering or rolling GO:0050901 9.56 SELE SELP
9 positive regulation of blood coagulation GO:0030194 9.55 APOH F2
10 negative regulation of blood coagulation GO:0030195 9.54 APOH THBD
11 leukocyte cell-cell adhesion GO:0007159 9.54 CD40LG SELE SELP
12 peptidyl-glutamic acid carboxylation GO:0017187 9.52 F10 F2
13 plasminogen activation GO:0031639 9.51 APOH PLAT
14 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
15 negative regulation of platelet activation GO:0010544 9.49 F2 THBD
16 blood coagulation, extrinsic pathway GO:0007598 9.46 F10 F3
17 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F10 F2
18 negative regulation of fibrinolysis GO:0051918 9.33 APOH F2 THBD
19 hemostasis GO:0007599 9.23 ADAMTS13 ANXA5 F10 F2 F3 F5

Molecular functions related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.83 ADAMTS13 ANXA5 F10 F2 THBD
2 heparin binding GO:0008201 9.46 APOH F2 SELP SERPINC1
3 glycoprotein binding GO:0001948 9.43 APOH PLAT SELP
4 sialic acid binding GO:0033691 9.37 SELE SELP
5 serine-type endopeptidase activity GO:0004252 9.35 F10 F2 F3 F5 PLAT
6 oligosaccharide binding GO:0070492 9.32 SELE SELP
7 phospholipid binding GO:0005543 8.92 ANXA5 APOH F10 F3
8 protein binding GO:0005515 10.25 ADAMTS13 ANXA5 APOH CD40LG CD79A F10

Sources for Antiphospholipid Syndrome

3 CDC
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10 dbSNP
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16 ExPASy
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