MCID: ANT006
MIFTS: 59

Antiphospholipid Syndrome

Categories: Rare diseases, Genetic diseases, Immune diseases

Aliases & Classifications for Antiphospholipid Syndrome

MalaCards integrated aliases for Antiphospholipid Syndrome:

Name: Antiphospholipid Syndrome 12 72 49 24 50 36 51 41 14 69
Antiphospholipid Antibody Syndrome 12 49 24 59
Hughes Syndrome 49 24 50
Familial Antiphospholipid Syndrome 49 69
Acromegaloid Facial Appearance Syndrome 69
Lupus Anticoagulant, Familial 49
Anti-Phospholipid Syndrome 24
Aps 49

Classifications:



External Ids:

Disease Ontology 12 DOID:2988
ICD10 32 D68.61
MeSH 41 D016736
NCIt 46 C61283
KEGG 36 H01697

Summaries for Antiphospholipid Syndrome

NINDS : 50 Antiphospholipid syndrome (APS) is an autoimmune disorder caused when antibodies -- immune system cells that fight off bacteria and viruses -- mistakenly attack healthy body tissues and organs.  In APS, specific antibodies activate the inner lining of blood vessels, which leads to the formation of blood clots in arteries or veins.  APS is sometimes called “sticky blood syndrome,” because of the increased tendency to form blood clots in the veins and arteries.  The symptoms of APS are due to the abnormal blood clotting.  Clots can develop in the veins of the legs and lungs, or in the placenta of pregnant women.  One of the most serious complications of APS occurs when a clot forms in the brain and causes a stroke.  Other neurological symptoms include chronic headaches, dementia (similar to the dementia of Alzheimer’s disease), and seizures.  Infrequently, individuals will develop chorea (a movement disorder in which the body and limbs writhe uncontrollably), cognitive dysfunction (such as poor memory), transverse myelitis, depression or psychosis, optic neuropathy, or sudden hearing loss.  In pregnant women, clots in the placenta can cause miscarriages.  APS is diagnosed by the presence of a positive antiphospholipid antibody and either a history of blood clots in an artery or vein or a history of multiple miscarriages or other pregnancy problems.  Some individuals will have a characteristic lacy, net-like red rash called livedo reticularis over their wrists and knees. 

MalaCards based summary : Antiphospholipid Syndrome, also known as antiphospholipid antibody syndrome, is related to catastrophic antiphospholipid syndrome and splenic infarction, and has symptoms including unspecified visual loss An important gene associated with Antiphospholipid Syndrome is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are homeostasis/metabolism and hematopoietic system

NIH Rare Diseases : 49 Antiphospholipid syndrome (APS) is an autoimmune disorder. Signs and symptoms vary, but may include blood clots, miscarriage, rash, chronic headaches, dementia, and seizures. APS occurs when your body's immune system makes antibodies that attack phospholipids. Phospholipids are a type of fat found in all living cells, including blood cells and the lining of blood vessels. Most cases of APS occur in people with no family history of the disorder, however there are rare cases of APS clustering in a family. A widely accepted explanation for APS is that it is caused by a combination of genemutations (making one more susceptible to APS) and an environmental exposure (such as to a virus). Currently there is not a cure for APS. The goal of treatment is to prevent blood clots from forming and to keep existing clots from getting larger. Last updated: 5/25/2016

Genetics Home Reference : 24 Antiphospholipid syndrome is a disorder characterized by an increased tendency to form abnormal blood clots (thromboses) that can block blood vessels. This clotting tendency is known as thrombophilia. In antiphospholipid syndrome, the thromboses can develop in nearly any blood vessel in the body, but most frequently occur in the vessels of the lower limbs. If a blood clot forms in the vessels in the brain, blood flow is impaired and can lead to stroke. Antiphospholipid syndrome is an autoimmune disorder. Autoimmune disorders occur when the immune system attacks the body's own tissues and organs.

Disease Ontology : 12 A hypersensitivity reaction type II disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).

PubMed Health : 59
About antiphospholipid antibody syndrome: Antiphospholipid (AN-te-fos-fo-LIP-id) antibody syndrome (APS) is an autoimmune disorder. Autoimmune disorders occur if the body's immune system makes antibodies that attack and damage tissues or cells. Antibodies are a type of protein. They usually help defend the body against infections. In APS, however, the body makes antibodies that mistakenly attack phospholipids—a type of fat. Phospholipids are found in all living cells and cell membranes, including blood cells and the lining of blood vessels.When antibodies attack phospholipids, cells are damaged. This damage causes blood clots to form in the body's arteries and veins. (These are the vessels that carry blood to your heart and body.)Usually, blood clotting is a normal bodily process. Blood clots help seal small cuts or breaks on blood vessel walls. This prevents you from losing too much blood. In APS, however, too much blood clotting can block blood flow and damage the body's organs.

Wikipedia : 72 Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune,... more...

Related Diseases for Antiphospholipid Syndrome

Diseases in the Antiphospholipid Syndrome family:

Antiphospholipid Syndrome, Familial

Diseases related to Antiphospholipid Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 484)
# Related Disease Score Top Affiliating Genes
1 catastrophic antiphospholipid syndrome 32.7 ADAMTS13 APOH CD40LG F3 F5 MTHFR
2 splenic infarction 30.4 APOH F2
3 endocarditis 30.4 APOH F2 SERPINC1
4 syphilis 30.0 APOH CD40LG CD79A
5 cerebral sinovenous thrombosis 29.8 APOH F2 F3 F5
6 coronary thrombosis 29.8 F3 PLAT SERPINC1
7 arteritic anterior ischemic optic neuropathy 29.7 F2 F5 MTHFR
8 thrombocytopenia 29.7 ADAMTS13 APOH F3 THBD
9 hepatic infarction 29.6 APOH F2 F3 MTHFR SERPINC1
10 nonarteritic anterior ischemic optic neuropathy 29.5 F2 F5 MTHFR SERPINC1
11 sneddon syndrome 29.5 APOH F2 F5 SERPINC1
12 retinal artery occlusion 29.5 APOH F2 F5 MTHFR SERPINC1
13 angina pectoris 29.5 F3 PLAT SERPINC1
14 heparin-induced thrombocytopenia 29.4 CD40LG F10 F3 SELP SERPINC1
15 acute myocardial infarction 29.4 F3 PLAT SELP SERPINC1
16 pulmonary hypertension 29.3 F3 PLAT SERPINC1 THBD
17 connective tissue disease 29.3 ADAMTS13 APOH CD40LG
18 ischemic optic neuropathy 29.3 APOH F2 F5 MTHFR SERPINC1
19 ischemic colitis 29.3 APOH F2 F5 SERPINC1
20 takayasu arteritis 29.3 CD40LG SELE THBD
21 sagittal sinus thrombosis 29.3 F2 F3 F5 SERPINC1
22 livedoid vasculopathy 29.2 APOH CD40LG F2 F5 MTHFR
23 sudden sensorineural hearing loss 29.2 F2 F5 MTHFR SERPINC1
24 protein s deficiency 29.2 APOH F2 F3 F5 MTHFR SERPINC1
25 retinal vein occlusion 29.2 APOH F2 F5 MTHFR SERPINC1
26 budd-chiari syndrome 29.1 APOH F2 F3 F5 MTHFR SERPINC1
27 eclampsia 29.0 F2 F5 MTHFR SERPINC1 THBD
28 vasculitis 29.0 APOH CD40LG CD79A SELE THBD
29 spinal cord infarction 28.9 APOH F2 F5 MTHFR SERPINC1
30 central retinal vein occlusion 28.9 APOH F2 F5 MTHFR SERPINC1
31 branch retinal artery occlusion 28.9 APOH CD40LG F2 F3 MTHFR SERPINC1
32 thrombophlebitis 28.9 APOH F2 F5 MTHFR PLAT SERPINC1
33 arteriosclerosis 28.9 F3 SELE SELP THBD
34 antithrombin iii deficiency 28.8 APOH F10 F2 F5 MTHFR SERPINC1
35 factor x deficiency 28.8 F10 F2 F3 F5 SERPINC1
36 patent foramen ovale 28.8 APOH F2 F5 MTHFR PLAT SERPINC1
37 retinal vascular occlusion 28.7 APOH F2 F5 MTHFR SELP SERPINC1
38 portal vein thrombosis 28.7 APOH F2 F5 MTHFR SELP SERPINC1
39 protein c deficiency 28.7 F2 F5 MTHFR SERPINC1 THBD
40 intracranial hypertension 28.6 APOH F2 F3 F5 MTHFR SERPINC1
41 thrombosis 28.4 APOH F10 F2 F3 F5 MTHFR
42 pulmonary embolism 28.4 APOH F10 F2 F3 F5 MTHFR
43 marantic endocarditis 28.4 F2 F3 MTHFR PLAT SERPINC1 THBD
44 thrombotic thrombocytopenic purpura 28.3 ADAMTS13 APOH F3 SELE SELP THBD
45 thrombophilia due to thrombin defect 28.1 APOH F10 F2 F3 F5 MTHFR
46 arteries, anomalies of 28.1 F2 F3 MTHFR PLAT SELE SELP
47 systemic lupus erythematosus 28.1 ADAMTS13 ANXA5 APOH CD40LG CD79A F2
48 stroke, ischemic 27.9 APOH F2 F3 F5 MTHFR PLAT
49 disseminated intravascular coagulation 27.8 ADAMTS13 F2 F3 F5 PLAT SERPINC1
50 hellp syndrome 27.8 ADAMTS13 APOH F2 F3 F5 MTHFR

Graphical network of the top 20 diseases related to Antiphospholipid Syndrome:



Diseases related to Antiphospholipid Syndrome

Symptoms & Phenotypes for Antiphospholipid Syndrome

UMLS symptoms related to Antiphospholipid Syndrome:


unspecified visual loss

MGI Mouse Phenotypes related to Antiphospholipid Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 APOH CD40LG F5 CD79A MTHFR F10
2 hematopoietic system MP:0005397 10.17 CD40LG CD79A PLAT F2 ADAMTS13 F3
3 cardiovascular system MP:0005385 10.16 F3 F5 CD40LG F10 PLAT F2
4 immune system MP:0005387 10.11 CD40LG CD79A PLAT F2 ADAMTS13 ANXA5
5 integument MP:0010771 9.97 CD40LG F5 MTHFR PLAT F2 F3
6 mortality/aging MP:0010768 9.97 APOH CD40LG F5 MTHFR F10 PLAT
7 liver/biliary system MP:0005370 9.73 F5 CD79A SELE SELP SERPINC1 THBD
8 nervous system MP:0003631 9.65 F3 F5 CD40LG CD79A MTHFR F2
9 vision/eye MP:0005391 9.17 F3 MTHFR ADAMTS13 SELE SELP SERPINC1

Drugs & Therapeutics for Antiphospholipid Syndrome

PubMedHealth treatment related to Antiphospholipid Syndrome: 59

Antiphospholipid antibody syndrome (APS) has no cure. However, medicines can help prevent complications. The goals of treatment are to prevent blood clots from forming and keep existing clots from getting larger.You may have APS and another autoimmune disorder, such as lupus. If so, it's important to control that condition as well. When the other condition is controlled, APS may cause fewer problems.Research is ongoing for new ways to treat APS.

Drugs for Antiphospholipid Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 9005-49-6 46507594 772
2
Dalteparin Approved Phase 4,Phase 2,Early Phase 1 9005-49-6
3
Acetaminophen Approved Phase 4,Phase 1 103-90-2 1983
4
Warfarin Approved Phase 4,Phase 3 81-81-2 54678486 6691
5
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
6
Apixaban Approved Phase 4 503612-47-3 10182969
7
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
9 calcium heparin Phase 4,Phase 1,Phase 2,Early Phase 1
10 Fibrinolytic Agents Phase 4,Phase 2,Early Phase 1
11 Heparin, Low-Molecular-Weight Phase 4,Phase 2,Early Phase 1
12 Vaccines Phase 4
13 Antibodies, Antiphospholipid Phase 4,Phase 3,Phase 2
14 Anticoagulants Phase 4,Phase 3,Phase 2,Early Phase 1
15 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
16 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
17 Analgesics Phase 4,Phase 2,Early Phase 1
18
protease inhibitors Phase 4,Phase 3
19 Micronutrients Phase 4
20 Serine Proteinase Inhibitors Phase 4,Phase 3
21 Trace Elements Phase 4
22 Hematinics Phase 4
23 Analgesics, Non-Narcotic Phase 4,Phase 2,Early Phase 1
24 HIV Protease Inhibitors Phase 4,Phase 3
25 Vitamin B Complex Phase 4
26 Vitamins Phase 4
27 Peripheral Nervous System Agents Phase 4,Phase 2,Early Phase 1
28 Factor Xa Inhibitors Phase 4,Phase 3
29 Antipyretics Phase 4,Phase 2,Early Phase 1
30 Antithrombin III Phase 4,Phase 3
31 Antithrombins Phase 4,Phase 3
32 serine Nutraceutical Phase 4,Phase 3
33 Folate Nutraceutical Phase 4
34 Vitamin B9 Nutraceutical Phase 4
35
Hydroxychloroquine Approved Phase 3,Phase 2 118-42-3 3652
36
Acenocoumarol Approved, Investigational Phase 3 152-72-7 54676537 9052
37 Autoantibodies Phase 3,Phase 1
38 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
39 Anti-Infective Agents Phase 3,Phase 2
40 Antimalarials Phase 3,Phase 2
41 Antiprotozoal Agents Phase 3,Phase 2
42 Antiparasitic Agents Phase 3,Phase 2
43
Aspirin Approved, Vet_approved Phase 1, Phase 2, Early Phase 1 50-78-2 2244
44
Fluvastatin Approved Phase 2 93957-54-1 1548972
45
rituximab Approved Phase 2 174722-31-7 10201696
46
Certolizumab pegol Approved Phase 2 428863-50-7
47 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
48 Anticholesteremic Agents Phase 2
49 Hypolipidemic Agents Phase 2
50 Antimetabolites Phase 2

Interventional clinical trials:

(show top 50) (show all 59)

# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Rivaroxaban for Antiphospholipid Antibody Syndrome Completed NCT02116036 Phase 4 Rivaroxaban
3 Timing of Initiation of LMWH Administration in Pregnant Women With APS Completed NCT02326051 Phase 4 Enoxaparin;Enoxaparin
4 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
5 Drug Interaction Between Paracetamol and Warfarin Completed NCT01104337 Phase 4 paracetamol;paracetamol;Placebo
6 Apixaban for the Secondary Prevention of Thromboembolism Among Patients With the AntiphosPholipid Syndrome Recruiting NCT02295475 Phase 4 Apixaban;Warfarin
7 Use of Warfarin After the First Trimester in Pregnant Women With APS Recruiting NCT02303171 Phase 4 Enoxaparin;Warfarin
8 Hydroxychloroquine for Prevention of Recurrent Miscarriage. Recruiting NCT03165136 Phase 3 Hydroxychloroquine;Placebo
9 Rivaroxaban for Patients With Antiphospholipid Syndrome Active, not recruiting NCT02926170 Phase 3 Rivaroxaban;acenocumarol
10 Rivaroxaban in Thrombotic Antiphospholipid Syndrome Terminated NCT02157272 Phase 3 Experimental: Rivaroxaban
11 Hydroxychloroquine for the First Thrombosis Prevention in Antiphospholipid Antibody Positive Patients Terminated NCT01784523 Phase 3 Hydroxychloroquine
12 Effects of Fluvastatin on Proinflammatory and Prothrombotic Markers in Antiphospholipid Syndrome Patients Unknown status NCT00674297 Phase 2 Fluvastatin
13 Steroids and Antiphospholipid Syndrome- Related Pregnancy Loss Unknown status NCT00180778 Phase 1, Phase 2 Low dose steroids
14 A Pilot Study of Rituximab for the Anticoagulation Resistant Manifestations of Antiphospholipid Syndrome Completed NCT00537290 Phase 2 Rituximab
15 Low-molecular-weight Heparin (LMWH) Versus Unfractionated Heparin (UFH) in Pregnant Women With Recurrent Abortion Secondary to Antiphospholipid Syndrome Completed NCT01051778 Phase 2 enoxaparin 40mg plus low dose aspirin;Heparin calcium5,000 U twice daily plus low dose aspirin
16 Aspirin in Asymmetrically Intrauterine Growth Completed NCT03038607 Phase 2 Aspirin
17 Study of the Efficiency of Hydroxychloroquine on the Endothelial Dysfunction and Its Vascular Consequences During the Antiphospholipid Syndrome Recruiting NCT02595346 Phase 2 Hydroxychloroquine;placebo
18 IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy Recruiting NCT03152058 Phase 2 Certolizumab Pegol
19 Eculizumab to Enable Renal Transplantation in Patients With History of Catastrophic Antiphospholipid Antibody Syndrome Active, not recruiting NCT01029587 Phase 2 Eculizumab
20 Phase IIa Trial of ALXN1007 for the Treatment of Non-criteria Manifestations of Antiphospholipid Syndrome Terminated NCT02128269 Phase 2
21 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
22 Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases Terminated NCT00849745 Phase 1
23 Hematopoietic Stem Cell Transplantation in Patients With Antiphospholipid Syndrome Withdrawn NCT00278616 Phase 1
24 Preconceptional Thromboprophylaxis in Recurrent PREGNANCY LOSSES Caused by Antiphospholipid Syndrome Unknown status NCT01661439 low molecular weight heparin (enoxeparine)
25 Antiphospholipid Antibodies and Early Severe Preeclampsia. Unknown status NCT01538121
26 Antiphospholipid Antibodies and Fetal Growth Restriction Unknown status NCT01538134
27 Longitudinal Study of the Clinical and Haematological Cause of Women With Antiphospholipid Antibodies. Unknown status NCT00180817
28 The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome Unknown status NCT01818505
29 Beneficial Effects of Coenzyme Q10 Treatment on the Mitochondrial Dysfunction and Oxidative Stress Associated to Atherothrombosis Developement in Antiphospholipidid Syndrome Patients Unknown status NCT02218476 CoQ10;Placebo
30 Monitoring Anticoagulant Therapy in Antiphospholipid Syndrome Completed NCT01660061
31 Antiphospholipid Syndrome Collaborative Registry (APSCORE) Completed NCT00076713
32 Reliability of Point-of-care INR Measurements in Patients With Antiphospholipid-antibody Syndrome Treated With Warfarin Completed NCT00878137
33 The Prognostic Value of PGF and sFlt1 Variations Induced by the First Low-molecular-weight-heparin Injections in Women With Obstetrical Antiphospholipids Antibody Syndrome Starting a New Pregnancy and Following Treatment in Accordance With International R Completed NCT02855047
34 Assessment of the Prevalence of Major Psychiatric Disorders in a Cohort of Women With Clinical Criteria Corresponding to Pure, Abortive-form, Obstetrical, Antiphospholipid Syndrome Completed NCT02833194
35 CoaguChek XS in Antiphospholipid Antibody Syndrome (APL) Patients Completed NCT02139072
36 Pilot Study of Cyclophosphamide in Patients With Life-Threatening Systemic Lupus Erythematosus or Antiphospholipid Antibody Syndrome Completed NCT00010400 Cyclophosphamide;filgrastim
37 Hypercoagulable Phenotype by Thrombinography (in Presence of C Protein Dynamic Inhibitory System) Completed NCT02892565
38 CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen Completed NCT01762891 Celecoxib;Acetaminophen;Rofecoxib;placebo
39 Effect of HCQ on AnxA5 Resistance Assay in Antiphospholipid (aPL) Positive Patients With and Without Systemic Lupus Erythematosus (SLE) Completed NCT01475149
40 Pharmacokinetics of Low Molecular Weight and Unfractionated Heparin in Pregnancy Completed NCT00721591
41 Promising Bimarker Prediction of Outcome of HELLP Syndrome. Completed NCT03246542
42 Clinical Significance of Antiphospholipid Antibodies in Healthy Subjects Completed NCT02803645
43 Pharmacogenetics of Warfarin in Puerto Ricans. Completed NCT01318057
44 Extra Corporeal Membrane Oxygenation in the Acute Respiratory Distress Syndrome: Utility of a Biomarker to Assess the Membrane Efficiency in Improving Oxygenation Completed NCT02879344
45 Register for Pediatric Patients With Antiphospholipid Syndrome (APS): European Project Extended Internationally Study Recruiting NCT00616317
46 Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome Recruiting NCT00482794
47 Register of Patients With Anti-Phospholipids Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE) Recruiting NCT02782039
48 AntiPhospholipid Syndrome Low-molecular-weight Heparin Pregnancy Loss Evaluation: The Pilot Study Recruiting NCT03100123 Early Phase 1 Aspirin 81 mg;Low-molecular-weight heparin
49 Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) Recruiting NCT00198068
50 Pregnancy and Medically Assisted Conception in Rare Diseases Recruiting NCT02450396

Search NIH Clinical Center for Antiphospholipid Syndrome

Cochrane evidence based reviews: antiphospholipid syndrome

Genetic Tests for Antiphospholipid Syndrome

Anatomical Context for Antiphospholipid Syndrome

MalaCards organs/tissues related to Antiphospholipid Syndrome:

38
Brain, Testes, Heart, Placenta, Endothelial, Lung, Monocytes

Publications for Antiphospholipid Syndrome

Articles related to Antiphospholipid Syndrome:

(show top 50) (show all 1459)
# Title Authors Year
1
Extra-criteria manifestations of antiphospholipid syndrome: Risk assessment and management. ( 29395258 )
2018
2
Arterial stenosis in antiphospholipid syndrome: Update on the unrevealed mechanisms of an endothelial disease. ( 29339317 )
2018
3
Platelet-activating factor acetylhydrolase in primary antiphospholipid syndrome. ( 29429123 )
2018
4
Genetic risk factors in thrombotic primary antiphospholipid syndrome: A systematic review with bioinformatic analyses. ( 29355608 )
2018
5
The antiphospholipid syndrome and its 'non-criteria' manifestations. ( 29449418 )
2018
6
Reversible Parkinsonism and Multiple Cerebral Infarctions after Pulmonary Endarterectomy in a Patient with Antiphospholipid Syndrome. ( 29321405 )
2018
7
Catastrophic antiphospholipid syndrome and pregnancy. Clinical report. ( 29284338 )
2018
8
Antiphospholipid syndrome. ( 29321641 )
2018
9
Thrombocytopenia in high-risk patients with antiphospholipid syndrome. ( 29316193 )
2018
10
Antiphospholipid syndrome. ( 29321639 )
2018
11
Antiphospholipid syndrome, "the best prophet of the future". ( 29385876 )
2018
12
Catastrophic antiphospholipid syndrome and pregnancy. ( 29179957 )
2018
13
Antiphosphatidylserine/prothrombin (aPS/PT) antibodies are associated with Raynaud phenomenon and migraine in primary thrombotic antiphospholipid syndrome. ( 29338587 )
2018
14
Oromandibular chorea in antiphospholipid syndrome. ( 29305492 )
2018
15
Rare Presentation of Catastrophic Antiphospholipid Syndrome with Myocarditis in Post-partum Period: Case Report and Review of Literature. ( 29391679 )
2018
16
Direct oral anticoagulant use in patients with thrombophilia, antiphospholipid syndrome or venous thrombosis of unusual sites: A narrative review. ( 29402471 )
2018
17
Antiphospholipid syndrome. ( 29368699 )
2018
18
Complement System Abnormalities in Patients with Atypical Hemolytic Uremic Syndrome and Catastrophic Antiphospholipid Syndrome. ( 29308852 )
2017
19
Coagulation and complement in antiphospholipid syndrome. ( 28917113 )
2017
20
Catastrophic antiphospholipid syndrome treated with rituximab: A case report. ( 28638691 )
2017
21
Intravascular Images of Coronary Stenosis with Multiple Channels in a Patient with Antiphospholipid Syndrome: The Optical Coherence Tomography Findings. ( 28566597 )
2017
22
Catastrophic antiphospholipid syndrome (CAPS)-induced ischemic pancreatic ducts injury mimicking intraductal papillary mucinous neoplasm (IPMN). ( 28802775 )
2017
23
Transient antiphospholipid syndrome and splenic infarction in a patient with parvovirus B19 acute infection. ( 28602215 )
2017
24
Catastrophic Antiphospholipid Syndrome: Candidate Therapies for a Potentially Lethal Disease. ( 28099080 )
2017
25
Catastrophic antiphospholipid syndrome (Ronald Asherson syndrome) and obstetric pathology. ( 28829758 )
2017
26
Can we withdraw anticoagulation in patients with antiphospholipid syndrome after seroconvertion? ( 28899804 )
2017
27
Rivaroxaban versus warfarin to treat patients with thrombotic antiphospholipid syndrome. Dr. Hannah Cohen about the results of the RAPS trial (Lancet Haematol 2016; 3: e426-36). ( 28859331 )
2017
28
Bilateral Choroidal Occlusion in Antiphospholipid Syndrome Associated with Systemic Lupus Erythematosus. ( 29301604 )
2017
29
Probable Catastrophic Antiphospholipid Syndrome with Intracerebral Hemorrhage Secondary to Epstein-Barr Viral Infection. ( 28357636 )
2017
30
Current insights in obstetric antiphospholipid syndrome. ( 28915160 )
2017
31
Fatal antiphospholipid syndrome following endoscopic transnasal-transsphenoidal surgery for a pituitary tumor: A case report. ( 28072724 )
2017
32
Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome. ( 28883515 )
2017
33
Protocol Modification of Apixaban for the Secondary Prevention of Thrombosis Among Patients With Antiphospholipid Syndrome Study. ( 28893087 )
2017
34
Closing the Serological Gap in the Antiphospholipid Syndrome: The Value of "Non-criteria" Antiphospholipid Antibodies. ( 28864642 )
2017
35
ANTIPHOSPHOLIPID SYNDROME AND MONOCYTES: NEW ASPECTS. ( 28820405 )
2017
36
Atypical bone change of spine caused by epidural venous thrombosis in systemic lupus erythematosus with antiphospholipid syndrome. ( 28063414 )
2017
37
Diagnosis and management of catastrophic antiphospholipid syndrome. ( 28277850 )
2017
38
Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome. ( 28515823 )
2017
39
Catastrophic antiphospholipid syndrome: an update. ( 28488841 )
2017
40
The catastrophic antiphospholipid syndrome in children. ( 28632503 )
2017
41
Perioperative anticoagulation management during aortic valve replacement complicated by antiphospholipid syndrome. ( 28944492 )
2017
42
Could Anticoagulation or Antiaggregation Treatment Be Ceased in Patients With Primary Antiphospholipid Syndrome When Antiphospholipid Antibodies Become Persistently Negative? ( 28832383 )
2017
43
A 15-year single centre retrospective study of antiphospholipid syndrome patients from Northern Malaysia. ( 28866693 )
2017
44
Kidney involvement in antiphospholipid syndrome - current diagnostic and management problems. ( 29332958 )
2017
45
Thrombotic management of antiphospholipid syndrome: Towards novel targeted therapies. ( 28056758 )
2017
46
Catastrophic antiphospholipid syndrome on switching from warfarin to rivaroxaban. ( 28319823 )
2017
47
Diagnostic value of antibodies to phosphatidylserine/prothrombin complex for antiphospholipid syndrome in Chinese patients. ( 28050648 )
2017
48
Impact of Classical Risk Factors for Arterial or Venous Thrombosis in Patients With Antiphospholipid Syndrome. ( 28884609 )
2017
49
Catastrophic antiphospholipid syndrome: A case with unusual findings revealed in autopsy and a brief literature update. ( 29308285 )
2017
50
Relationship Between Fetal Loss and Serum Gonadal Hormones Level in Experimental Antiphospholipid Syndrome Mouse. ( 28811696 )
2017

Variations for Antiphospholipid Syndrome

Copy number variations for Antiphospholipid Syndrome from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 160790 22 16300000 24300000 Deletion Hughes'' syndrome

Expression for Antiphospholipid Syndrome

Search GEO for disease gene expression data for Antiphospholipid Syndrome.

Pathways for Antiphospholipid Syndrome

Pathways related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 ANXA5 APOH F10 F2 F3 F5
2
Show member pathways
12.46 F10 F2 F3 F5 SERPINC1 THBD
3
Show member pathways
11.92 F2 SELE SELP THBD
4 11.78 PLAT SELE THBD
5
Show member pathways
11.7 F10 F2 F3 F5 PLAT SERPINC1
6 11.58 F3 SELE THBD
7 11.31 F10 F2 F3 F5 PLAT SERPINC1
8 11.19 CD40LG SELE SELP
9 10.61 F10 F2

GO Terms for Antiphospholipid Syndrome

Cellular components related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 ADAMTS13 APOH CD40LG F3 PLAT THBD
2 endoplasmic reticulum lumen GO:0005788 9.65 ADAMTS13 F10 F2 F5 SERPINC1
3 extracellular region GO:0005576 9.65 ADAMTS13 ANXA5 APOH CD40LG F10 F2
4 external side of plasma membrane GO:0009897 9.55 ANXA5 CD40LG CD79A F2 SELP
5 intrinsic component of external side of plasma membrane GO:0031233 9.37 F10 F3
6 extracellular space GO:0005615 9.36 ADAMTS13 APOH CD40LG F2 F3 F5

Biological processes related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.76 F2 SELE SELP THBD
2 platelet activation GO:0030168 9.73 ADAMTS13 CD40LG F2
3 platelet degranulation GO:0002576 9.71 ANXA5 APOH F5 SELP
4 blood coagulation GO:0007596 9.61 ADAMTS13 ANXA5 F10 F2 F3 F5
5 fibrinolysis GO:0042730 9.58 F2 PLAT
6 signal peptide processing GO:0006465 9.57 F10 F2
7 leukocyte tethering or rolling GO:0050901 9.55 SELE SELP
8 negative regulation of blood coagulation GO:0030195 9.54 APOH THBD
9 leukocyte cell-cell adhesion GO:0007159 9.54 CD40LG SELE SELP
10 positive regulation of blood coagulation GO:0030194 9.52 APOH F2
11 peptidyl-glutamic acid carboxylation GO:0017187 9.51 F10 F2
12 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
13 plasminogen activation GO:0031639 9.49 APOH PLAT
14 negative regulation of platelet activation GO:0010544 9.48 F2 THBD
15 blood coagulation, extrinsic pathway GO:0007598 9.43 F10 F3
16 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F10 F2
17 negative regulation of fibrinolysis GO:0051918 9.33 APOH F2 THBD
18 hemostasis GO:0007599 9.23 ADAMTS13 ANXA5 F10 F2 F3 F5

Molecular functions related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.67 F10 F2 F3 PLAT
2 calcium ion binding GO:0005509 9.63 ADAMTS13 ANXA5 F10 F2 SELP THBD
3 sialic acid binding GO:0033691 9.32 SELE SELP
4 oligosaccharide binding GO:0070492 9.26 SELE SELP
5 heparin binding GO:0008201 9.26 APOH F2 SELP SERPINC1
6 phospholipid binding GO:0005543 8.92 ANXA5 APOH F10 F3
7 protein binding GO:0005515 10.25 ADAMTS13 ANXA5 APOH CD40LG CD79A F10

Sources for Antiphospholipid Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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