MCID: ANT006
MIFTS: 54

Antiphospholipid Syndrome

Categories: Rare diseases, Immune diseases, Genetic diseases

Aliases & Classifications for Antiphospholipid Syndrome

MalaCards integrated aliases for Antiphospholipid Syndrome:

Name: Antiphospholipid Syndrome 12 50 25 51 52 42 14 69
Antiphospholipid Antibody Syndrome 12 50 25
Hughes Syndrome 50 25 51
Familial Antiphospholipid Syndrome 50 69
Acromegaloid Facial Appearance Syndrome 69
Lupus Anticoagulant, Familial 50
Anti-Phospholipid Syndrome 25
Aps 50

Classifications:



External Ids:

Disease Ontology 12 DOID:2988
ICD10 33 D68.61
MeSH 42 D016736
NCIt 47 C61283
UMLS 69 C0085278

Summaries for Antiphospholipid Syndrome

NINDS : 51 Antiphospholipid syndrome (APS) is an autoimmune disorder caused when antibodies -- immune system cells that fight off bacteria and viruses -- mistakenly attack healthy body tissues and organs.  In APS, specific antibodies activate the inner lining of blood vessels, which leads to the formation of blood clots in arteries or veins.  APS is sometimes called “sticky blood syndrome,” because of the increased tendency to form blood clots in the veins and arteries.  The symptoms of APS are due to the abnormal blood clotting.  Clots can develop in the veins of the legs and lungs, or in the placenta of pregnant women.  One of the most serious complications of APS occurs when a clot forms in the brain and causes a stroke.  Other neurological symptoms include chronic headaches, dementia (similar to the dementia of Alzheimer’s disease), and seizures.  Infrequently, individuals will develop chorea (a movement disorder in which the body and limbs writhe uncontrollably), cognitive dysfunction (such as poor memory), transverse myelitis, depression or psychosis, optic neuropathy, or sudden hearing loss.  In pregnant women, clots in the placenta can cause miscarriages.  APS is diagnosed by the presence of a positive antiphospholipid antibody and either a history of blood clots in an artery or vein or a history of multiple miscarriages or other pregnancy problems.  Some individuals will have a characteristic lacy, net-like red rash called livedo reticularis over their wrists and knees. 

MalaCards based summary : Antiphospholipid Syndrome, also known as antiphospholipid antibody syndrome, is related to hyperthyroidism and sagittal sinus thrombosis, and has symptoms including blurred vision and unspecified visual loss. An important gene associated with Antiphospholipid Syndrome is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Dalteparin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and placenta, and related phenotypes are homeostasis/metabolism and hematopoietic system

NIH Rare Diseases : 50 antiphospholipid syndrome (aps) is an autoimmune disorder. signs and symptoms vary, but may include blood clots, miscarriage, rash, chronic headaches, dementia, and seizures. aps occurs when your body's immune system makes antibodies that attack phospholipids. phospholipids are a type of fat found in all living cells, including blood cells and the lining of blood vessels. most cases of aps occur in people with no family history of the disorder, however there are rare cases of aps clustering in a family. a widely accepted explanation for aps is that it is caused by a combination of genemutations (making one more susceptible to aps) and an environmental exposure (such as to a virus). currently there is not a cure for aps. the goal of treatment is to prevent blood clots from forming and to keep existing clots from getting larger. last updated: 5/25/2016

Genetics Home Reference : 25 Antiphospholipid syndrome is a disorder characterized by an increased tendency to form abnormal blood clots (thromboses) that can block blood vessels. This clotting tendency is known as thrombophilia. In antiphospholipid syndrome, the thromboses can develop in nearly any blood vessel in the body, but most frequently occur in the vessels of the lower limbs. If a blood clot forms in the vessels in the brain, blood flow is impaired and can lead to stroke. Antiphospholipid syndrome is an autoimmune disorder. Autoimmune disorders occur when the immune system attacks the body's own tissues and organs.

Disease Ontology : 12 A hypersensitivity reaction type II disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).

Wikipedia : 72 Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune,... more...

Related Diseases for Antiphospholipid Syndrome

Diseases in the Antiphospholipid Syndrome family:

Antiphospholipid Syndrome, Familial

Diseases related to Antiphospholipid Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 468)
id Related Disease Score Top Affiliating Genes
1 hyperthyroidism 30.4 F2 F3
2 sagittal sinus thrombosis 30.0 F3 SERPINC1
3 factor x deficiency 29.9 F10 F2 F3
4 inferior myocardial infarction 29.6 PLAT SERPINC1
5 lymphoma 29.5 APOH CD40LG CD79A
6 adult respiratory distress syndrome 29.0 F3 PLAT SELP SERPINC1
7 budd-chiari syndrome 28.9 APOH F2 F3 F5 MTHFR SERPINC1
8 priapism 28.8 F5 MTHFR SERPINC1 THBD
9 cysticercosis 28.8 CD79A SELE
10 central retinal artery occlusion 28.8 APOH CD40LG F2 F3 MTHFR SERPINC1
11 peripheral artery disease 28.2 F2 F3 MTHFR PLAT SELE SELP
12 systemic lupus erythematosus 27.9 ADAMTS13 APOH CD40LG CD79A F3 SELE
13 angina pectoris 27.2 F2 F3 PLAT SELE SELP SERPINC1
14 myeloproliferative neoplasm 26.9 ADAMTS13 CD40LG F10 F2 F3 SELP
15 myocardial infarction 25.2 ADAMTS13 ANXA5 CD40LG F10 F2 F3
16 catastrophic antiphospholipid syndrome 12.3
17 antiphospholipid syndrome, familial 12.1
18 neonatal antiphospholipid syndrome 11.9
19 mcgillivray syndrome 10.9 APOH F5
20 brown's tendon sheath syndrome 10.9 APOH CD40LG
21 landau-kleffner syndrome 10.9 APOH F2
22 accessory deep peroneal nerve 10.8 APOH F5
23 variably protease-sensitive prionopathy 10.8 F2 F5
24 alcoholic gastritis 10.8 APOH CD40LG
25 rubella 10.8 APOH CD40LG
26 von willibrand disease, type 3 10.8 F2 F3
27 acquired von willebrand syndrome 10.8 F3 F5
28 porphyria 10.8 F2 MTHFR
29 multicentric osteolysis nephropathy 10.8 F5 MTHFR
30 x-linked intellectual disability-hypogonadism-ichthyosis-obesity-short stature syndrome 10.8
31 coronary sinus stenosis 10.8 F5 MTHFR
32 amelogenesis imperfecta hypomaturation type 10.7 F5 MTHFR
33 bile duct cystadenoma 10.7 F2 F5
34 motor neuron disease 10.7 CD40LG PLAT
35 chronic inflammatory demyelinating polyneuritis 10.7 CD40LG F2 F3
36 ovarian endometrioid cystadenoma 10.6 APOH CD40LG F3
37 dentinogenesis imperfecta 10.6 CD40LG F2 F3
38 female breast cancer 10.6 F2 F3
39 facioscapulohumeral muscular dystrophy 1 10.6 F2 F3 F5
40 factor v deficiency 10.6 F2 F3 F5
41 prostatitis 10.6 APOH F2
42 inherited blood coagulation disease 10.6 F2 F3 F5
43 moderately severe hemophilia b 10.6 F2 F3 F5
44 diphyllobothriasis 10.6 CD40LG SERPINC1
45 pregnancy loss, recurrent 1 10.6 APOH F5 MTHFR
46 primary pigmented nodular adrenocortical disease 10.6 F2 F5 MTHFR
47 thalassemia-beta, dominant inclusion-body 10.6 CD40LG F2 MTHFR
48 mesomelia 10.6 PLAT THBD
49 immunodeficiency 32b, monocyte and dendritic cell deficiency, autosomal recessive 10.5 PLAT THBD
50 homologous wasting disease 10.5 F2 F5 MTHFR

Graphical network of the top 20 diseases related to Antiphospholipid Syndrome:



Diseases related to Antiphospholipid Syndrome

Symptoms & Phenotypes for Antiphospholipid Syndrome

UMLS symptoms related to Antiphospholipid Syndrome:


blurred vision, unspecified visual loss

MGI Mouse Phenotypes related to Antiphospholipid Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ADAMTS13 APOH CD40LG CD79A F10 F2
2 hematopoietic system MP:0005397 10.17 ADAMTS13 ANXA5 CD40LG CD79A F2 F3
3 cardiovascular system MP:0005385 10.16 SELP SERPINC1 THBD CD40LG F10 F2
4 immune system MP:0005387 10.11 F3 PLAT SELE SELP SERPINC1 THBD
5 mortality/aging MP:0010768 9.97 ADAMTS13 APOH CD40LG F10 F2 F3
6 integument MP:0010771 9.92 CD40LG F2 F3 F5 MTHFR SELE
7 liver/biliary system MP:0005370 9.73 CD79A F5 SELE SELP SERPINC1 THBD
8 nervous system MP:0003631 9.65 CD79A F2 F3 F5 MTHFR PLAT
9 vision/eye MP:0005391 9.17 ADAMTS13 F3 MTHFR PLAT SELE SELP

Drugs & Therapeutics for Antiphospholipid Syndrome

Drugs for Antiphospholipid Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4,Phase 2,Early Phase 1 9005-49-6
2
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 9005-49-6 772 46507594
3
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
4
Acetaminophen Approved Phase 4,Phase 1 103-90-2 1983
5
Warfarin Approved Phase 4,Phase 3 81-81-2 6691 54678486
6
Apixaban Approved Phase 4 503612-47-3 10182969
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
9 Vaccines Phase 4
10 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
11 Antibodies, Antiphospholipid Phase 4,Phase 3,Phase 2
12 Anticoagulants Phase 4,Phase 3,Phase 2,Early Phase 1
13 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
14 calcium heparin Phase 4,Phase 1,Phase 2,Early Phase 1
15 Heparin, Low-Molecular-Weight Phase 4,Phase 2,Early Phase 1
16 Fibrinolytic Agents Phase 4,Phase 2,Early Phase 1
17 Antithrombin III Phase 4,Phase 3
18 Antithrombins Phase 4,Phase 3
19 Factor Xa Inhibitors Phase 4,Phase 3
20 HIV Protease Inhibitors Phase 4,Phase 3
21
protease inhibitors Phase 4,Phase 3
22 Serine Proteinase Inhibitors Phase 4,Phase 3
23 Hematinics Phase 4
24 Micronutrients Phase 4
25 Trace Elements Phase 4
26 Vitamin B Complex Phase 4
27 Vitamins Phase 4
28 Analgesics Phase 4,Phase 2,Early Phase 1
29 Analgesics, Non-Narcotic Phase 4,Phase 2,Early Phase 1
30 Antipyretics Phase 4,Phase 2,Early Phase 1
31 Peripheral Nervous System Agents Phase 4,Phase 2,Early Phase 1
32 serine Nutraceutical Phase 4,Phase 3
33 Folate Nutraceutical Phase 4
34 Vitamin B9 Nutraceutical Phase 4
35
Hydroxychloroquine Approved Phase 3,Phase 2 118-42-3 3652
36
Acenocoumarol Approved Phase 3 152-72-7 9052 54676537
37 Autoantibodies Phase 3,Phase 1
38 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
39 Anti-Infective Agents Phase 3,Phase 2
40 Antimalarials Phase 3,Phase 2
41 Antiparasitic Agents Phase 3,Phase 2
42 Antiprotozoal Agents Phase 3,Phase 2
43
Fluvastatin Approved Phase 2 93957-54-1 1548972
44
Aspirin Approved, Vet_approved Phase 1, Phase 2, Early Phase 1 50-78-2 2244
45
rituximab Approved Phase 2 174722-31-7 10201696
46
Certolizumab pegol Approved Phase 2 428863-50-7
47 Anticholesteremic Agents Phase 2
48 Antimetabolites Phase 2
49 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
50 Hypolipidemic Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 57)

id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Rivaroxaban for Antiphospholipid Antibody Syndrome Completed NCT02116036 Phase 4 Rivaroxaban
3 Timing of Initiation of LMWH Administration in Pregnant Women With APS Completed NCT02326051 Phase 4 Enoxaparin;Enoxaparin
4 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
5 Drug Interaction Between Paracetamol and Warfarin Completed NCT01104337 Phase 4 paracetamol;paracetamol;Placebo
6 Apixaban for the Secondary Prevention of Thromboembolism Among Patients With the AntiphosPholipid Syndrome Recruiting NCT02295475 Phase 4 Apixaban;Warfarin
7 Use of Warfarin After the First Trimester in Pregnant Women With APS Recruiting NCT02303171 Phase 4 Enoxaparin;Warfarin
8 Rivaroxaban in Thrombotic Antiphospholipid Syndrome Recruiting NCT02157272 Phase 3 Experimental: Rivaroxaban
9 Rivaroxaban for Patients With Antiphospholipid Syndrome Active, not recruiting NCT02926170 Phase 3 Rivaroxaban;acenocumarol
10 Hydroxychloroquine for Prevention of Recurrent Miscarriage. Not yet recruiting NCT03165136 Phase 3 Hydroxychloroquine;Placebo
11 Hydroxychloroquine for the First Thrombosis Prevention in Antiphospholipid Antibody Positive Patients Terminated NCT01784523 Phase 3 Hydroxychloroquine
12 Effects of Fluvastatin on Proinflammatory and Prothrombotic Markers in Antiphospholipid Syndrome Patients Unknown status NCT00674297 Phase 2 Fluvastatin
13 Steroids and Antiphospholipid Syndrome- Related Pregnancy Loss Unknown status NCT00180778 Phase 1, Phase 2 Low dose steroids
14 A Pilot Study of Rituximab for the Anticoagulation Resistant Manifestations of Antiphospholipid Syndrome Completed NCT00537290 Phase 2 Rituximab
15 Low-molecular-weight Heparin (LMWH) Versus Unfractionated Heparin (UFH) in Pregnant Women With Recurrent Abortion Secondary to Antiphospholipid Syndrome Completed NCT01051778 Phase 2 enoxaparin 40mg plus low dose aspirin;Heparin calcium5,000 U twice daily plus low dose aspirin
16 Aspirin in Asymmetrically Intrauterine Growth Completed NCT03038607 Phase 2 Aspirin
17 Study of the Efficiency of Hydroxychloroquine on the Endothelial Dysfunction and Its Vascular Consequences During the Antiphospholipid Syndrome Recruiting NCT02595346 Phase 2 Hydroxychloroquine;placebo
18 IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy Recruiting NCT03152058 Phase 2 Certolizumab Pegol
19 Eculizumab to Enable Renal Transplantation in Patients With History of Catastrophic Antiphospholipid Antibody Syndrome Active, not recruiting NCT01029587 Phase 2 Eculizumab
20 Phase IIa Trial of ALXN1007 for the Treatment of Non-criteria Manifestations of Antiphospholipid Syndrome Terminated NCT02128269 Phase 2
21 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
22 Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases Terminated NCT00849745 Phase 1
23 Hematopoietic Stem Cell Transplantation in Patients With Antiphospholipid Syndrome Withdrawn NCT00278616 Phase 1
24 Preconceptional Thromboprophylaxis in Recurrent PREGNANCY LOSSES Caused by Antiphospholipid Syndrome Unknown status NCT01661439 low molecular weight heparin (enoxeparine)
25 Antiphospholipid Antibodies and Early Severe Preeclampsia. Unknown status NCT01538121
26 Antiphospholipid Antibodies and Fetal Growth Restriction Unknown status NCT01538134
27 Longitudinal Study of the Clinical and Haematological Cause of Women With Antiphospholipid Antibodies. Unknown status NCT00180817
28 The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome Unknown status NCT01818505
29 Beneficial Effects of Coenzyme Q10 Treatment on the Mitochondrial Dysfunction and Oxidative Stress Associated to Atherothrombosis Developement in Antiphospholipidid Syndrome Patients Unknown status NCT02218476 CoQ10;Placebo
30 Monitoring Anticoagulant Therapy in Antiphospholipid Syndrome Completed NCT01660061
31 Antiphospholipid Syndrome Collaborative Registry (APSCORE) Completed NCT00076713
32 Reliability of Point-of-care INR Measurements in Patients With Antiphospholipid-antibody Syndrome Treated With Warfarin Completed NCT00878137
33 The Prognostic Value of PGF and sFlt1 Variations Induced by the First Low-molecular-weight-heparin Injections in Women With Obstetrical Antiphospholipids Antibody Syndrome Starting a New Pregnancy and Following Treatment in Accordance With International R Completed NCT02855047
34 CoaguChek XS in Antiphospholipid Antibody Syndrome (APL) Patients Completed NCT02139072
35 Assessment of the Prevalence of Major Psychiatric Disorders in a Cohort of Women With Clinical Criteria Corresponding to Pure, Abortive-form, Obstetrical, Antiphospholipid Syndrome Completed NCT02833194
36 Pilot Study of Cyclophosphamide in Patients With Life-Threatening Systemic Lupus Erythematosus or Antiphospholipid Antibody Syndrome Completed NCT00010400 Cyclophosphamide;filgrastim
37 Hypercoagulable Phenotype by Thrombinography (in Presence of C Protein Dynamic Inhibitory System) Completed NCT02892565
38 CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen Completed NCT01762891 Celecoxib;Acetaminophen;Rofecoxib;placebo
39 Effect of HCQ on AnxA5 Resistance Assay in Antiphospholipid (aPL) Positive Patients With and Without Systemic Lupus Erythematosus (SLE) Completed NCT01475149
40 Pharmacokinetics of Low Molecular Weight and Unfractionated Heparin in Pregnancy Completed NCT00721591
41 Promising Bimarker Prediction of Outcome of HELLP Syndrome. Completed NCT03246542
42 Clinical Significance of Antiphospholipid Antibodies in Healthy Subjects Completed NCT02803645
43 Pharmacogenetics of Warfarin in Puerto Ricans. Completed NCT01318057
44 Extra Corporeal Membrane Oxygenation in the Acute Respiratory Distress Syndrome: Utility of a Biomarker to Assess the Membrane Efficiency in Improving Oxygenation Completed NCT02879344
45 Register for Pediatric Patients With Antiphospholipid Syndrome (APS): European Project Extended Internationally Study Recruiting NCT00616317
46 Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome Recruiting NCT00482794
47 Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS) Recruiting NCT00198068
48 Register of Patients With Anti-Phospholipids Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE) Recruiting NCT02782039
49 Pregnancy and Medically Assisted Conception in Rare Diseases Recruiting NCT02450396
50 Phenomics in Autoimmune and Inflammatory Diseases Recruiting NCT02466217

Search NIH Clinical Center for Antiphospholipid Syndrome

Cochrane evidence based reviews: antiphospholipid syndrome

Genetic Tests for Antiphospholipid Syndrome

Anatomical Context for Antiphospholipid Syndrome

MalaCards organs/tissues related to Antiphospholipid Syndrome:

39
Brain, Testes, Placenta, Lung, Endothelial, Monocytes, Bone

Publications for Antiphospholipid Syndrome

Articles related to Antiphospholipid Syndrome:

(show top 50) (show all 1436)
id Title Authors Year
1
Factors associated with adverse pregnancy outcomes in women with antiphospholipid syndrome: A multicenter study. ( 28837832 )
2017
2
Vascular Manifestations in Antiphospholipid Syndrome (APS): Is APS a Thrombophilia or a Vasculopathy? ( 28871481 )
2017
3
Intravascular Images of Coronary Stenosis with Multiple Channels in a Patient with Antiphospholipid Syndrome: The Optical Coherence Tomography Findings. ( 28566597 )
2017
4
Dental care in patients with antiphospholipid syndrome: two case reports. ( 28068274 )
2017
5
The return of a former foe: syphilis with antiphospholipid syndrome as a cause of acute stroke. ( 28904807 )
2017
6
Thrombotic management of antiphospholipid syndrome: Towards novel targeted therapies. ( 28056758 )
2017
7
Cellular immune response to I^2-glycoprotein-I valine/leucine(247) phenotypes in Mexican patients with primary antiphospholipid syndrome. ( 28038927 )
2017
8
Protocol Modification of Apixaban for the Secondary Prevention of Thrombosis Among Patients With Antiphospholipid Syndrome Study. ( 28893087 )
2017
9
Can we withdraw anticoagulation in patients with antiphospholipid syndrome after seroconvertion? ( 28899804 )
2017
10
Perioperative anticoagulation management during aortic valve replacement complicated by antiphospholipid syndrome. ( 28944492 )
2017
11
Closing the Serological Gap in the Antiphospholipid Syndrome: The Value of "Non-criteria" Antiphospholipid Antibodies. ( 28864642 )
2017
12
A 15-year single centre retrospective study of antiphospholipid syndrome patients from Northern Malaysia. ( 28866693 )
2017
13
The catastrophic antiphospholipid syndrome in children. ( 28632503 )
2017
14
Atypical bone change of spine caused by epidural venous thrombosis in systemic lupus erythematosus with antiphospholipid syndrome. ( 28063414 )
2017
15
Patient with antiphospholipid syndrome presenting with testicular torsion-like symptoms. ( 28932692 )
2017
16
Rivaroxaban versus warfarin to treat patients with thrombotic antiphospholipid syndrome. Dr. Hannah Cohen about the results of the RAPS trial (Lancet Haematol 2016; 3: e426-36). ( 28859331 )
2017
17
Fatal antiphospholipid syndrome following endoscopic transnasal-transsphenoidal surgery for a pituitary tumor: A case report. ( 28072724 )
2017
18
Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic target. ( 28931754 )
2017
19
Catastrophic antiphospholipid syndrome on switching from warfarin to rivaroxaban. ( 28319823 )
2017
20
Impact of Classical Risk Factors for Arterial or Venous Thrombosis in Patients With Antiphospholipid Syndrome. ( 28884609 )
2017
21
Current insights in obstetric antiphospholipid syndrome. ( 28915160 )
2017
22
Lupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome. ( 28515823 )
2017
23
Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome. ( 28883515 )
2017
24
Catastrophic antiphospholipid syndrome: an update. ( 28488841 )
2017
25
Diagnostic value of antibodies to phosphatidylserine/prothrombin complex for antiphospholipid syndrome in Chinese patients. ( 28050648 )
2017
26
Catastrophic antiphospholipid syndrome (Ronald Asherson syndrome) and obstetric pathology. ( 28829758 )
2017
27
Catastrophic antiphospholipid syndrome (CAPS)-induced ischemic pancreatic ducts injury mimicking intraductal papillary mucinous neoplasm (IPMN). ( 28802775 )
2017
28
Could Anticoagulation or Antiaggregation Treatment Be Ceased in Patients With Primary Antiphospholipid Syndrome When Antiphospholipid Antibodies Become Persistently Negative? ( 28832383 )
2017
29
Autoantibodies to types I and IV collagen and heart valve disease in systemic lupus erythematosus/antiphospholipid syndrome. ( 28283766 )
2017
30
Diagnosis and management of catastrophic antiphospholipid syndrome. ( 28277850 )
2017
31
Relationship Between Fetal Loss and Serum Gonadal Hormones Level in Experimental Antiphospholipid Syndrome Mouse. ( 28811696 )
2017
32
ANTIPHOSPHOLIPID SYNDROME AND MONOCYTES: NEW ASPECTS. ( 28820405 )
2017
33
In Vitro Fertilization in 37 Women with Systemic Lupus Erythematosus or Antiphospholipid Syndrome: A Series of 97 Procedures. ( 28089975 )
2017
34
Probable Catastrophic Antiphospholipid Syndrome with Intracerebral Hemorrhage Secondary to Epstein-Barr Viral Infection. ( 28357636 )
2017
35
Catastrophic Antiphospholipid Syndrome: Candidate Therapies for a Potentially Lethal Disease. ( 28099080 )
2017
36
Coagulation and complement in antiphospholipid syndrome. ( 28917113 )
2017
37
Catastrophic antiphospholipid syndrome treated with rituximab: A case report. ( 28638691 )
2017
38
Antiphospholipid syndrome: A diagnostic challenge. ( 28050066 )
2016
39
Catastrophic Antiphospholipid Syndrome Triggered by Fulminant Chikungunya Infection in a Patient With Systemic Lupus Erythematosus. ( 26748818 )
2016
40
Vitamin D deficiency in antiphospholipid syndrome. ( 27994369 )
2016
41
Bilateral Superficial Femoral Artery Thrombosis in a 15-Year-Old Caucasian Male with Homozygous Prothrombin G20210A Genotype and Associated Antiphospholipid Syndrome. ( 28031668 )
2016
42
Gene expression in obstetric antiphospholipid syndrome: a systematic review. ( 28028299 )
2016
43
Catastrophic antiphospholipid syndrome in pregnancy, a diagnosis that should not be missed. ( 27023104 )
2016
44
'Non-criteria' neurologic manifestations of antiphospholipid syndrome: A hidden kingdom to be discovered. ( 27658514 )
2016
45
Takayasu's arteritis and primary antiphospholipid syndrome presenting as hypertensive urgency. ( 26783006 )
2016
46
MACULAR PERIVENOUS RETINAL WHITENING AND PRESUMED RETINO-CILIARY SPARING IN A RECURRENT CENTRAL RETINAL VEIN OCCLUSION ASSOCIATED WITH THE ANTIPHOSPHOLIPID SYNDROME AND CRYOGLOBULINEMIA. ( 27902540 )
2016
47
Renal involvement in primary antiphospholipid syndrome. ( 27198137 )
2016
48
Immunity and early atherosclerosis in the course of systemic lupus erythematosus, mixed connective tissue disease and antiphospholipid syndrome. ( 27826173 )
2016
49
Rivaroxaban versus warfarin to treat patients with thrombotic antiphospholipid syndrome, with or without systemic lupus erythematosus (RAPS): a randomised, controlled, open-label, phase 2/3, non-inferiority trial. ( 27570089 )
2016
50
Antiphospholipid antibodies detected by line immunoassay differentiate among patients with antiphospholipid syndrome, with infections and asymptomatic carriers. ( 27209064 )
2016

Variations for Antiphospholipid Syndrome

Copy number variations for Antiphospholipid Syndrome from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 160790 22 16300000 24300000 Deletion Hughes'' syndrome

Expression for Antiphospholipid Syndrome

Search GEO for disease gene expression data for Antiphospholipid Syndrome.

Pathways for Antiphospholipid Syndrome

Pathways related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 ANXA5 APOH F10 F2 F3 F5
2
Show member pathways
12.46 F10 F2 F3 F5 SERPINC1 THBD
3
Show member pathways
11.92 F2 SELE SELP THBD
4
Show member pathways
11.71 F10 F2 F3 F5 PLAT SERPINC1
5 11.58 F3 SELE THBD
6 11.31 F10 F2 F3 F5 PLAT SERPINC1
7 11.19 CD40LG SELE SELP
8 10.61 F10 F2

GO Terms for Antiphospholipid Syndrome

Cellular components related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 ADAMTS13 APOH CD40LG F3 PLAT THBD
2 endoplasmic reticulum lumen GO:0005788 9.65 ADAMTS13 F10 F2 F5 SERPINC1
3 extracellular region GO:0005576 9.65 ADAMTS13 ANXA5 APOH CD40LG F10 F2
4 external side of plasma membrane GO:0009897 9.55 ANXA5 CD40LG CD79A F2 SELP
5 intrinsic component of external side of plasma membrane GO:0031233 9.37 F10 F3
6 extracellular space GO:0005615 9.36 ADAMTS13 APOH CD40LG F2 F3 F5

Biological processes related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.76 F2 SELE SELP THBD
2 platelet activation GO:0030168 9.73 ADAMTS13 CD40LG F2
3 platelet degranulation GO:0002576 9.71 ANXA5 APOH F5 SELP
4 blood coagulation GO:0007596 9.61 ADAMTS13 ANXA5 F10 F2 F3 F5
5 fibrinolysis GO:0042730 9.58 F2 PLAT
6 signal peptide processing GO:0006465 9.57 F10 F2
7 leukocyte tethering or rolling GO:0050901 9.55 SELE SELP
8 negative regulation of blood coagulation GO:0030195 9.54 APOH THBD
9 leukocyte cell-cell adhesion GO:0007159 9.54 CD40LG SELE SELP
10 positive regulation of blood coagulation GO:0030194 9.52 APOH F2
11 peptidyl-glutamic acid carboxylation GO:0017187 9.51 F10 F2
12 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
13 plasminogen activation GO:0031639 9.49 APOH PLAT
14 negative regulation of platelet activation GO:0010544 9.48 F2 THBD
15 blood coagulation, extrinsic pathway GO:0007598 9.43 F10 F3
16 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F10 F2
17 negative regulation of fibrinolysis GO:0051918 9.33 APOH F2 THBD
18 hemostasis GO:0007599 9.23 ADAMTS13 ANXA5 F10 F2 F3 F5

Molecular functions related to Antiphospholipid Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.8 ADAMTS13 ANXA5 F10 F2 THBD
2 serine-type endopeptidase activity GO:0004252 9.62 F10 F2 F3 PLAT
3 sialic acid binding GO:0033691 9.26 SELE SELP
4 heparin binding GO:0008201 9.26 APOH F2 SELP SERPINC1
5 oligosaccharide binding GO:0070492 9.16 SELE SELP
6 phospholipid binding GO:0005543 8.92 ANXA5 APOH F10 F3
7 protein binding GO:0005515 10.21 ADAMTS13 ANXA5 APOH CD40LG CD79A F10

Sources for Antiphospholipid Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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