ASP
MCID: ANT011
MIFTS: 57

Antisocial Personality Disorder (ASP) malady

Neuronal diseases category

Summaries for Antisocial Personality Disorder

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.

MalaCards: Antisocial Personality Disorder, also known as psychopathic personality disorder, is related to personality disorder and substance abuse. An important gene associated with Antisocial Personality Disorder is MAOA (monoamine oxidase A), and among its related pathways are Enzymatic degradation of dopamine by COMT and melatonin degradation II. The compounds p-chloroamphetamine and minaprine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Wikipedia:63 Antisocial (or dissocial) personality disorder is characterized by a pervasive pattern of disregard for,... more...

Aliases & Classifications for Antisocial Personality Disorder

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

antisocial personality disorder 8 42 10 44 60
psychopathic personality disorder 8
dissocial personality disorder 8
psychopathic personality 8
sociopathic personality 8
psychopath.personality 8
asocial personality 8
asp 42


External Ids:

Disease Ontology8 DOID:10939
MeSH34 D000987
ICD9CM27 301.7
ICD1025 F60.2

Related Diseases for Antisocial Personality Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Antisocial Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder32.1HTR1B, TTF2, MAOB, MAOA, DRD2, SLC6A3
2substance abuse31.2DRD2, ALDH2, SLC6A4, SLC6A3
3conduct disorder31.1TTF2, MAOA, DRD2, COMT, SLC6A3, SLC6A4
4schizophrenia31.1COMT, HTR2A
5borderline personality disorder31.0MAOA, HTR1B, SLC6A4, TTF2
6alcohol dependence30.9HTR1B, ALDH2, HTR2A, MAOA, ANKK1, GABRA6
7cocaine dependence30.9SLC6A3, DRD2, SLC6A4
8substance dependence30.9COMT, DRD2, SLC6A3, SLC6A4
9anxiety disorder30.9SLC6A4, MAOA
10heroin dependence30.7DRD2, ANKK1
11alcohol abuse30.7ALDH2, SLC6A4, SLC6A3, COMT, DRD2
12pathological gambling30.6DRD2, SLC6A3
13bipolar disorder30.4HTR2A, SLC6A4, MAOA
14drug dependence30.4MAOA, SLC6A3, DRD2, SLC6A4
15attention deficit hyperactivity disorder30.4COMT, HTR1B, HTR2A, DRD2, SNAP25, SLC6A4
16alexithymia30.2ANKK1
17cocaine abuse30.2SLC6A4, SLC6A3, DRD2
18bulimia nervosa30.2COMT, SLC6A4, MAOA, HTR2A, HTR1B
19dementia30.2MAOA, MAOB, TTF2, ALDH2, SLC6A3, HTR2A
20obesity30.1HTR2A, DRD2, MAOA, MAOB, TTF2, SLC6A3
21hepatitis30.0TTF2, COMT
22hypertension29.8SLC6A4
23diabetes mellitus29.8ALDH2
24dependent personality disorder10.9
25sexual disorder10.5
26thalassemia10.5
27sleep disorder10.4
28alpha thalassemia10.4
29aspergillosis10.4
30beta thalassemia10.3
31alveolar soft part sarcoma10.3
32somatization disorder10.3
33sexual sadism10.3
34impulse control disorder10.3
35allergic bronchopulmonary aspergillosis10.3
36coronary artery disease10.2
37sarcoma10.2
38dissociative disorder10.2
39lung cancer10.2
40major depressive disorder10.2
41narcissistic personality disorder10.2
42histrionic personality disorder10.2
43physical disorder10.2
44leukemia10.2
45canavan disease10.1
46hypophosphatasia10.1
47hemolytic anemia10.1
48intellectual disability10.1
49stroke, ischemic10.0
50melanoma10.0

Graphical network of the top 20 diseases related to Antisocial Personality Disorder:



Diseases related to antisocial personality disorder

Clinical Features for Antisocial Personality Disorder

About this section

Drugs & Therapeutics for Antisocial Personality Disorder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Antisocial Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Antisocial Personality Disorder

Search NIH Clinical Center for Antisocial Personality Disorder

Search CenterWatch for Antisocial Personality Disorder

Genetic Tests for Antisocial Personality Disorder

About this section

Anatomical Context for Antisocial Personality Disorder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Antisocial Personality Disorder:

32
Brain, Eye, Cortex, Testes, Prefrontal cortex

Animal Models for Antisocial Personality Disorder or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Antisocial Personality Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4SLC6A4, SLC6A3, SNAP25, DRD2, HTR2A, HTR1B
2MP:00053797.9SLC6A4, SLC6A3, PRL, DRD2, SNAP25, HTR2A
3MP:00053907.7SLC6A3, SNAP25, GABRB2, DRD2, HTR2A, HTR1B
4MP:00053897.4COMT, HTR1B, DRD2, SNAP25, PRL, SLC6A3
5MP:00036316.4MAOA, DRD2, GABRB2, ALDH2, SLC6A4, SLC6A3
6MP:00053766.3PRL, MAOA, SNAP25, GABRA6, GABRB2, DRD2
7MP:00053865.9GABRA6, MAOA, PRL, SNAP25, GABRB2, DRD2

Publications for Antisocial Personality Disorder

About this section
Sources:
50PubMed
See all sources

Articles related to Antisocial Personality Disorder:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
The social construction of violence among Northern Plains tribal members with antisocial personality disorder and alcohol use disorder. (24045407)
2014
2
Comorbidity of social anxiety disorder and antisocial personality disorder in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). (24384071)
2013
3
Sex differences in antisocial personality disorder: results from the National Epidemiological Survey on Alcohol and Related Conditions. (23544428)
2013
4
Cool and hot executive function impairments in violent offenders with antisocial personality disorder with and without psychopathy. (23840340)
2013
5
Antisocial personality disorder predicts methamphetamine treatment outcomes in homeless, substance-dependent men who have sex with men. (23579078)
2013
6
Borderline Personality Disorder, Bulimia Nervosa, Antisocial Personality Disorder, ADHD, Substance Use: Common Threads, Common Treatment Needs, and the Nature of Impulsivity. (21253443)
2010
7
What should be done with antisocial personality disorder in the new edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V)? (20979622)
2010
8
Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics. (20505557)
2010
9
Antisocial personality disorder and anxiety disorder: a diagnostic variant? (20378309)
2010
10
Identifying subtypes among offenders with antisocial personality disorder: a cluster-analytic study. (20455611)
2010
11
Emotional, cognitive and physiological correlates of abuse-related stress in borderline and antisocial personality disorder. (19854433)
2010
12
A treatment guideline for people with antisocial personality disorder: overcoming attitudinal barriers and evidential limitations. (19343700)
2009
13
Latent structure of a two-dimensional model of antisocial personality disorder: construct validation and taxometric analysis. (20001180)
2009
14
Antisocial personality disorder as a predictor of criminal behaviour in a longitudinal study of a cohort of abusers of several classes of drugs: relation to type of substance and type of crime. (18258375)
2008
15
Gender differences in contributions of emotion to psychopathy and antisocial personality disorder. (18945529)
2008
16
Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populations. (17452294)
2007
17
Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder. (17470955)
2007
18
Psychophysiological and behavioural characteristics of individuals comorbid for antisocial personality disorder and schizophrenia-spectrum personality disorder. (17978320)
2007
19
Antisocial personality disorder and medical certification. (17310889)
2007
20
High prognostic specificity of antisocial personality disorder in patients with drug dependence: results from a five-year follow-up. (16923669)
2006
21
Effect of patient sex, clinician sex, and sex role on the diagnosis of Antisocial Personality Disorder: models of underpathologizing and overpathologizing biases. (15141394)
2004
22
Lifetime comorbidity of antisocial personality disorder and anxiety disorders among adults in the community. (12606017)
2003
23
Sleep among habitually violent offenders with antisocial personality disorder. (12824743)
2003
24
Followup of cocaine-dependent men and women with antisocial personality disorder. (14670521)
2003
25
Altered affective modulation of the startle reflex in alcoholics with antisocial personality disorder. (14691377)
2003
26
Modeling growth in boys' aggressive behavior across elementary school: links to later criminal involvement, conduct disorder, and antisocial personality disorder. (14584982)
2003
27
Suicidal behavior as essential diagnostic feature of antisocial personality disorder. (11799325)
2001
28
Increased height and bulk in antisocial personality disorder and its subtypes. (11814540)
2001
29
HIV risk behaviors in male substance abusers with and without antisocial personality disorder. (10867302)
2000
30
Use of health services by men with and without antisocial personality disorder who are alcohol dependent. (10686248)
2000
31
Sadistic personality disorder in sex offenders: relationship to antisocial personality disorder and sexual sadism. (10372350)
1999
32
Antisocial personality disorder and alcohol-induced aggression. (9884131)
1998
33
Smooth pursuit eye movement dysfunction in substance-dependent patients: mediating effects of antisocial personality disorder. (9597667)
1998
34
CSF 5-HIAA and family history of antisocial personality disorder in newborns. (9396964)
1997
35
Death rates in 71 men with antisocial personality disorder. A comparison with general population mortality. (8742541)
1996
36
Antisocial personality disorder: a biopsychosocial model. (8705966)
1996
37
A 16- to 45-year follow-up of 71 men with antisocial personality disorder. (7758299)
1995
38
Six cases of patients with mental retardation who have antisocial personality disorder. (7583487)
1995
39
Personality and disinhibitory psychopathology: alcoholism and antisocial personality disorder. (8040486)
1994
40
A comparison of alternate systems for diagnosing antisocial personality disorder in cocaine abusers. (8320546)
1993
41
The Lifestyle Criminality Screening Form and Antisocial Personality Disorder: predicting release outcome in a state prison sample. (10150226)
1993
42
Major mental disorder and antisocial personality disorder: a criminal combination. (8364234)
1993
43
Psychopathology and addictive disorders. The specific case of antisocial personality disorder. (1535930)
1992
44
Case report: acquired antisocial personality disorder associated with unilateral left orbital frontal lobe damage. (1390621)
1992
45
A case of pseudologia fantastica with antisocial personality disorder. (1742719)
1991
46
An empirical study of object relations and defensive operations in antisocial personality disorder. (2348344)
1990
47
HIV risk behavior: antisocial personality disorder, drug use patterns, and sexual behavior among methadone maintenance admissions. (2641008)
1989
48
Alcoholism in males with antisocial personality disorder. (3235225)
1988
49
The relationship of histrionic personality disorder to antisocial personality and somatization disorders. (3717392)
1986
50
Diagnosis of antisocial personality disorder in two prison populations. (6859306)
1983

Genetic Variations for Antisocial Personality Disorder

About this section

Expression for genes affiliated with Antisocial Personality Disorder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Antisocial Personality Disorder

Search GEO for disease gene expression data for Antisocial Personality Disorder.

Pathways for genes affiliated with Antisocial Personality Disorder

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 49PharmGKB
See all sources

Pathways related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7ALDH2, SLC6A3, MAOA
2
Hide members
9.6ALDH2, MAOB, MAOA
3
Hide members
9.6ALDH2, MAOB, MAOA
49.6ALDH2, MAOB, MAOA
59.6MAOA, MAOB, ALDH2
6
Hide members
9.6MAOA, MAOB, ALDH2
7
Hide members
9.5COMT, MAOA, MAOB
8
Hide members
9.5COMT, MAOA, MAOB
9
Tyrosine metabolism p.1 (dopamine)
Hide members
9.5MAOB, MAOA, COMT
109.4DRD2, MAOA, MAOB, SLC6A3
11
Hide members
9.4DRD2, MAOA, MAOB, SLC6A3
12
Hide members
9.2HTR1B, HTR2A, DRD2, MAOA, SLC6A4
13
Hide members
9.2ALDH2, MAOB, MAOA, COMT
148.9HTR2A, SNAP25, MAOA, SLC6A4
15
Hide members
8.4HTR1B, HTR2A, DRD2, GABRB2, GABRA6, PRL
16
Hide members
7.6COMT, GABRB2, GABRA6, SNAP25, MAOA, SLC6A3
17
Hide members
7.3SLC6A4, COMT, HTR1B, HTR2A, DRD2, GABRB2

Compounds for genes affiliated with Antisocial Personality Disorder

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 283)
idCompoundScoreTop Affiliating Genes
1p-chloroamphetamine449.7SLC6A4, SLC6A3, MAOB, MAOA
2minaprine44 1110.7SLC6A4, MAOA, DRD2, HTR2A
3phentermine44 1110.7SLC6A4, SLC6A3, MAOB, MAOA
44-Methoxyamphetamine119.7SLC6A4, SLC6A3, MAOB, MAOA
5d amphetamine449.5DRD2, MAOA, MAOB, SLC6A3, SLC6A4
6mcpp449.5SLC6A4, HTR1B, HTR2A, PRL
7MMDA119.5MAOB, HTR2A, MAOA, SLC6A4, SLC6A3
8Ephedra119.5SLC6A4, SLC6A3, MAOA, MAOB
9venlafaxine49 44 11 2412.5SLC6A4, SLC6A3, HTR2A, HTR1B, GABRA6
10pindolol44 28 1111.4SLC6A4, HTR1B, PRL, HTR2A
11clomipramine44 49 1111.4MAOA, HTR2A, SLC6A3, SLC6A4, PRL
12amoxapine44 28 1111.4SLC6A4, PRL, DRD2, HTR2A
13trimipramine49 44 1111.4SLC6A4, HTR2A, DRD2, PRL, SLC6A3
14mdma449.3PRL, MAOA, MAOB, SLC6A3, SLC6A4
15amitriptyline44 49 28 1112.3MAOA, SLC6A4, MAOB, SLC6A3, HTR2A
16tyramine44 28 2411.3COMT, SLC6A4, SLC6A3, MAOB, MAOA
17terguride28 4410.3PRL, HTR1B, HTR2A, DRD2
18ropinirole44 1110.3HTR1B, HTR2A, MAOB, DRD2, COMT
19sertindole28 44 1111.2PRL, DRD2, HTR2A, HTR1B
20quetiapine44 49 28 11 2413.2HTR2A, SLC6A3, HTR1B, DRD2, PRL
21pergolide28 44 1111.2HTR1B, HTR2A, DRD2, PRL, COMT
22carbidopa44 2810.2SLC6A3, MAOB, COMT, PRL
23cabergoline28 44 1111.2HTR1B, PRL, COMT, DRD2, HTR2A
24mhpg449.2MAOA, MAOB, SLC6A4, COMT, PRL
25methylphenidate44 49 1111.2COMT, DRD2, MAOA, MAOB, SLC6A3, SLC6A4
26amphetamine44 1110.1SLC6A4, SLC6A3, DRD2, MAOA, MAOB
27homovanillic acid44 2410.1MAOA, COMT, PRL, MAOB, SLC6A4
28methamphetamine44 49 1111.1SLC6A4, MAOB, MAOA, DRD2, COMT, SLC6A3
29mptp449.1SLC6A3, SLC6A4, COMT, MAOA, DRD2, MAOB
30citalopram49 44 11 2412.0SLC6A4, SLC6A3, HTR2A, PRL, MAOA, MAOB
31bupropion44 49 11 2412.0COMT, DRD2, ANKK1, MAOB, SLC6A3, SLC6A4
32pramipexole44 49 28 1112.0COMT, HTR2A, HTR1B, PRL, SLC6A3, DRD2
33bromocriptine28 44 1111.0HTR1B, SLC6A3, PRL, DRD2, HTR2A, COMT
34ritanserin28 449.9PRL, HTR1B, DRD2, HTR2A
35haloperidol44 28 2 49 1112.9DRD2, PRL, MAOB, SLC6A3, SLC6A4, HTR2A
366-hydroxydopamine448.9DRD2, COMT, SLC6A3, MAOB, MAOA
37paroxetine44 49 28 1111.8HTR2A, COMT, HTR1B, PRL, SLC6A4, SLC6A3
38olanzapine49 44 28 11 2412.7HTR1B, SLC6A3, HTR2A, DRD2, PRL, ANKK1
39levodopa44 119.7COMT, HTR1B, MAOB, DRD2, SLC6A3, MAOA
40maoa448.7HTR1B, MAOB, HTR2A, DRD2, MAOA, SLC6A3
41apomorphine44 28 1110.7MAOB, PRL, COMT, DRD2, HTR1B, HTR2A
42cocaine44 119.6SLC6A4, SLC6A3, MAOB, DRD2, PRL, HTR1B
43fluoxetine49 44 28 1111.6SLC6A4, SLC6A3, MAOB, MAOA, PRL, DRD2
44nicotine44 49 28 1111.6SLC6A3, TTF2, DRD2, ANKK1, COMT, MAOA
45risperidone28 44 49 59 11 2413.5COMT, SLC6A4, SLC6A3, ANKK1, PRL, DRD2
46clozapine44 28 49 1111.5DRD2, PRL, ANKK1, SLC6A3, SLC6A4, HTR2A
47gaba448.2GABRA6, SNAP25, MAOA, MAOB, SLC6A3, SLC6A4
485-hydroxytryptamine448.2PRL, MAOA, MAOB, SLC6A4, DRD2, HTR2A
49norepinephrine44 11 249.6COMT, SLC6A3, HTR2A, SLC6A4, DRD2, SNAP25
50dopamine44 28 11 2410.1SLC6A3, SLC6A4, MAOB, MAOA, PRL, ALDH2

GO Terms for genes affiliated with Antisocial Personality Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058877.5SLC6A4, COL25A1, HTR1B, HTR2A, DRD2, GABRB2
2plasma membraneGO:0058866.6COMT, HTR1B, HTR2A, DRD2, GABRB2, GABRA6

Biological processes related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1monoamine transportGO:01584410.2SLC6A4, SLC6A3
2adenohypophysis developmentGO:02198410.2SLC6A3, DRD2
3G-protein coupled receptor internalizationGO:00203110.1HTR1B, DRD2
4negative regulation of serotonin secretionGO:01406310.1HTR1B, MAOB
5regulation of behaviorGO:05079510.1HTR2A, HTR1B
6neurotransmitter catabolic processGO:04213510.1MAOA, COMT
7response to iron ionGO:01003910.0DRD2, SLC6A3
8response to cocaineGO:04222010.0HTR1B, SLC6A3, DRD2
9negative regulation of synaptic transmission, glutamatergicGO:05196710.0HTR1B, DRD2, HTR2A
10regulation of dopamine secretionGO:01405910.0HTR1B, HTR2A, DRD2
11vasoconstrictionGO:04231010.0HTR1B, SLC6A4
12prepulse inhibitionGO:06013410.0SLC6A3, DRD2
13dopamine catabolic processGO:0424209.9MAOA, SLC6A3, COMT
14response to toxic substanceGO:0096369.8DRD2, SLC6A4, MAOB
15temperature homeostasisGO:0016599.6DRD2, HTR2A
16neurotransmitter biosynthetic processGO:0421369.6ALDH2, SLC6A3, MAOA, COMT
17response to ethanolGO:0454719.5HTR1B, MAOB, SLC6A3, PRL
18xenobiotic metabolic processGO:0068059.4COMT, ALDH2, MAOA, MAOB
19response to lipopolysaccharideGO:0324969.1COMT, MAOB, PRL
20response to drugGO:0424938.5HTR2A, DRD2, PRL, MAOB, SLC6A3, SLC6A4
21synaptic transmissionGO:0072687.4COMT, GABRB2, GABRA6, SNAP25, MAOA, SLC6A3

Molecular functions related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.0SLC6A4, SLC6A3
2primary amine oxidase activityGO:0081319.9MAOA, MAOB
3serotonin bindingGO:0513789.9HTR2A, HTR1B
4dopamine bindingGO:0352409.7SLC6A3, DRD2
5GABA-A receptor activityGO:0048909.6GABRA6, GABRB2
6drug bindingGO:0081449.6SLC6A3, DRD2, HTR2A, HTR1B

Products for genes affiliated with Antisocial Personality Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Antisocial Personality Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet