MCID: ANT011
MIFTS: 51

Antisocial Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Antisocial Personality Disorder

MalaCards integrated aliases for Antisocial Personality Disorder:

Name: Antisocial Personality Disorder 12 72 51 41 14 69
Psychopathic Personality Disorder 12
Dissocial Personality Disorder 12
Psychopathic Personality 12
Sociopathic Personality 12
Psychopath.personality 12
Asocial Personality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10939
ICD10 32 F60.2
ICD9CM 34 301.7
MeSH 41 D000987
NCIt 46 C88413
UMLS 69 C0003431

Summaries for Antisocial Personality Disorder

Disease Ontology : 12 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.

MalaCards based summary : Antisocial Personality Disorder, also known as psychopathic personality disorder, is related to impulse control disorder and conduct disorder. An important gene associated with Antisocial Personality Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Transmission across Chemical Synapses and Circadian entrainment. The drugs Naratriptan and Sumatriptan have been mentioned in the context of this disorder. Affiliated tissues include cortex, prefrontal cortex and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 72 Antisocial personality disorder (ASPD or APD) is a personality disorder characterized by a long term... more...

Related Diseases for Antisocial Personality Disorder

Diseases related to Antisocial Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 impulse control disorder 31.8 ANKK1 DRD2
2 conduct disorder 31.0 ALDH2 COMT DRD2 MAOA SLC6A3 SLC6A4
3 cocaine dependence 30.7 DRD2 SLC6A3 SLC6A4
4 borderline personality disorder 30.5 COMT MAOA SLC6A4
5 heroin dependence 30.4 ANKK1 DRD2 SLC6A3
6 substance dependence 30.3 DRD2 MAOA SLC6A3 SLC6A4
7 anxiety 30.3 COMT MAOA SLC6A3 SLC6A4
8 generalized anxiety disorder 30.2 DRD2 MAOA SLC6A4
9 alcohol use disorder 30.2 ALDH2 DRD2 SLC6A4
10 substance abuse 30.1 COMT DRD2 MAOA SLC6A3 SLC6A4
11 cocaine abuse 30.0 DRD2 SLC6A3 SLC6A4
12 bulimia nervosa 1 29.9 COMT MAOA SLC6A4
13 drug dependence 29.8 ANKK1 DRD2 SLC6A4
14 personality disorder 29.7 ALDH2 COMT DRD2 MAOA MAOB SLC6A3
15 alcohol abuse 29.5 ALDH2 ANKK1 DRD2 SLC6A4
16 alexithymia 29.3 ANKK1 COMT DRD2 SLC6A4
17 disease of mental health 29.2 ALDH2 COMT DRD2 MAOA SLC6A3 SLC6A4
18 pathological gambling 29.0 DRD2 MAOA MAOB SLC6A3 SLC6A4
19 bipolar disorder 28.6 COMT DRD2 MAOA SLC6A3 SLC6A4 SNAP25
20 schizophrenia 28.4 COMT DRD2 MAOA MAOB SLC6A3 SLC6A4
21 alcohol dependence 28.0 ALDH2 ANKK1 COMT DRD2 MAOA MAOB
22 attention deficit-hyperactivity disorder 27.2 ANKK1 COMT DRD2 MAOA MAOB SLC6A3
23 dysthymic disorder 10.4 MAOA SLC6A4
24 kleptomania 10.4 MAOA SLC6A4
25 agoraphobia 10.3 MAOA SLC6A4
26 periodic limb movement disorder 10.3 DRD2 SLC6A4
27 bruxism 10.3 DRD2 SLC6A4
28 striatonigral degeneration 10.3 DRD2 SLC6A3
29 phobia, specific 10.3 COMT MAOA
30 tic disorder 10.2 DRD2 SLC6A3
31 schizophreniform disorder 10.2 COMT DRD2
32 polysubstance abuse 10.2 COMT DRD2
33 tardive dyskinesia 10.2 COMT DRD2
34 taqi polymorphism 10.2 ANKK1 DRD2
35 social phobia 10.2 DRD2 MAOA SLC6A4
36 migraine without aura 10.2 DRD2 SLC6A4
37 alcohol-induced mental disorder 10.1 DRD2 SLC6A3 SLC6A4
38 alcoholic psychosis 10.1 DRD2 SLC6A3 SLC6A4
39 opiate dependence 10.1 DRD2 SLC6A4
40 migraine with aura 10.1 DRD2 SLC6A3 SLC6A4
41 opioid addiction 10.1 COMT DRD2
42 phobic disorder 10.1 COMT MAOA SLC6A4
43 brunner syndrome 10.1 COMT MAOA SLC6A4
44 kleine-levin hibernation syndrome 10.1 COMT SLC6A3
45 traumatic brain injury 10.1 COMT DRD2
46 paranoid schizophrenia 10.1 COMT MAOA SLC6A4
47 postpartum depression 10.1 COMT MAOA SLC6A4
48 mental depression 10.1 COMT MAOA SLC6A4
49 chronic fatigue syndrome 10.0 COMT MAOA SLC6A4
50 premature ejaculation 10.0 COMT SLC6A3 SLC6A4

Comorbidity relations with Antisocial Personality Disorder via Phenotypic Disease Network (PDN):


Schizophreniform Disorder

Graphical network of the top 20 diseases related to Antisocial Personality Disorder:



Diseases related to Antisocial Personality Disorder

Symptoms & Phenotypes for Antisocial Personality Disorder

MGI Mouse Phenotypes related to Antisocial Personality Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ALDH2 SLC6A4 COL25A1 SNAP25 COMT DRD2
2 homeostasis/metabolism MP:0005376 9.91 SLC6A3 ALDH2 SLC6A4 COL25A1 SNAP25 COMT
3 endocrine/exocrine gland MP:0005379 9.8 SLC6A3 ALDH2 SLC6A4 SNAP25 COMT DRD2
4 nervous system MP:0003631 9.61 ALDH2 SLC6A4 COL25A1 SNAP25 COMT DRD2
5 muscle MP:0005369 9.55 SLC6A3 SLC6A4 COL25A1 SNAP25 DRD2
6 taste/olfaction MP:0005394 8.8 SLC6A3 SNAP25 DRD2

Drugs & Therapeutics for Antisocial Personality Disorder

Drugs for Antisocial Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naratriptan Approved, Investigational Phase 4 143388-64-1, 121679-13-8 4440
2
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
3 Neurotransmitter Agents Phase 4
4 Vasoconstrictor Agents Phase 4,Phase 1
5
Serotonin Phase 4 50-67-9 5202
6 Serotonin 5-HT1 Receptor Agonists Phase 4
7 Serotonin Agents Phase 4
8 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3
9 Arginine Vasopressin Phase 1
10 Coagulants Phase 1
11 Hemostatics Phase 1
12 Natriuretic Agents Phase 1
13 Vasopressins Phase 1
14 arginine Nutraceutical Phase 1
15
Guanfacine Approved, Investigational 29110-47-2 3519
16
Norepinephrine Approved 51-41-2 439260
17
Yohimbine Approved, Investigational, Vet_approved 146-48-5 8969
18
Dopamine Approved 51-61-6, 62-31-7 681
19
Ethanol Approved 64-17-5 702
20
Morphine Approved, Investigational 57-27-2 5288826
21 Adrenergic Agents
22 Adrenergic Agonists
23 Adrenergic alpha-Agonists
24 Autonomic Agents
25 Peripheral Nervous System Agents
26 Central Nervous System Stimulants
27 Dopamine Agents
28 Dopamine Uptake Inhibitors
29 Lisdexamfetamine Dimesylate
30 Neurotransmitter Uptake Inhibitors
31 Yohimbe Nutraceutical

Interventional clinical trials:

(show all 26)

# Name Status NCT ID Phase Drugs
1 Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA) Completed NCT00000388 Phase 4 Anti-ADHD medication
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4 naratriptan;placebo
3 Effect of Omega-3 Supplementation on Child Behavior Problems Completed NCT02016079 Phase 2, Phase 3
4 Working Memory Training in Adults With Substance Abuse and Executive Function Deficits. Unknown status NCT02068261 Phase 2
5 The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention Completed NCT01532934 Phase 2
6 Vasopressin Effects on Human Social Communication Completed NCT01327027 Phase 1 Vasopressin, Arginine, ADH;Placebo; Sterile Saline
7 Antisocial Behavior: Passing From Parent to Child to Grandchild Unknown status NCT00060788
8 Mental Health Related to School Dropout in Luxembourg Unknown status NCT01354236
9 Conduct Disorder in Prison: Search for Prospective and Retrospective Recurring and Contextual Elements Completed NCT02493088
10 Matching Cognitive Remediation to Cognitive Deficits in Substance-Abusing Inmates Completed NCT01428349
11 Impaired Decision-making in Adolescents Completed NCT01253993 Early Phase 1
12 The Role of Norepinephrine in Emotional Processing Completed NCT00109642
13 Psychological Mechanisms of Behavioral Dysregulation Completed NCT00352456
14 Early Exposure to Lead and Adult Antisocial Outcomes Completed NCT00285610
15 To Evaluate the Safety and Metabolic Profile of Vyvanse for the Treatment of ADHD in Euthymic Adults With Bipolar I/II Disorder Completed NCT01263548 lisdexamfetamine dimesylate
16 Effectiveness of a Cognitive-behavioral Program of Coping With Psychological Stress in People With Retinitis Pigmentosa Completed NCT03368027
17 Justice-Involved Veterans and Moral Reconation Therapy Recruiting NCT02524171
18 Emotion Recognition Training in Antisocial Violent Offenders With Psychopathic Traits Recruiting NCT03382808
19 An 18-Month Psychotherapy of Borderline Personality Disorder Recruiting NCT03329677
20 Multisystemic Therapy-Emerging Adults (MST-EA) for Substance Abuse Recruiting NCT03035877
21 Multisystemic Therapy-Emerging Adults Trial Recruiting NCT02922335
22 The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior Recruiting NCT02427672
23 The Effect of Repeated Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior Active, not recruiting NCT02674516
24 Multisite Prevention of Conduct Problems (Fast Track) Active, not recruiting NCT01653535
25 Psychobiological Effects of Meditation on Offenders With Psychopathy Not yet recruiting NCT02894203
26 Role of Oxytocin in Telling and Detecting Lies Withdrawn NCT02361177 Early Phase 1 Oxytocin

Search NIH Clinical Center for Antisocial Personality Disorder

Cochrane evidence based reviews: antisocial personality disorder

Genetic Tests for Antisocial Personality Disorder

Anatomical Context for Antisocial Personality Disorder

MalaCards organs/tissues related to Antisocial Personality Disorder:

38
Cortex, Prefrontal Cortex, Brain, Testes, Amygdala, Thyroid, Eye

Publications for Antisocial Personality Disorder

Articles related to Antisocial Personality Disorder:

(show top 50) (show all 379)
# Title Authors Year
1
The effects of working memory load and attention refocusing on delay discounting rates in alcohol use disorder with comorbid antisocial personality disorder. ( 29277285 )
2018
2
Episodic memory and consciousness in antisocial personality disorder and conduct disorder. ( 29353574 )
2018
3
Association of monoamine oxidase-A genetic variants and amygdala morphology in violent offenders with antisocial personality disorder and high psychopathic traits. ( 28851912 )
2017
4
Antisocial Personality Disorder in Older Adults: A Critical Review. ( 28954596 )
2017
5
Neuropsychology and emotion processing in violent individuals with antisocial personality disorder or schizophrenia: The same or different? A systematic review and meta-analysis. ( 28992741 )
2017
6
Neurocognitive dysfunction in problem gamblers with co-occurring antisocial personality disorder. ( 28528231 )
2017
7
Oxytocin improves facial emotion recognition in young adults with antisocial personality disorder. ( 28865940 )
2017
8
Genetic and Environmental Structure of DSM-IV Criteria for Antisocial Personality Disorder: A Twin Study. ( 28108863 )
2017
9
Neural Mechanisms Underlying Affective Theory of Mind in Violent Antisocial Personality Disorder and/or Schizophrenia. ( 28199713 )
2017
10
Reduced White Matter Integrity in Antisocial Personality Disorder: A Diffusion Tensor Imaging Study. ( 28223713 )
2017
11
Did you get any help? A post-hoc secondary analysis of a randomized controlled trial of psychoeducation for patients with antisocial personality disorder in outpatient substance abuse treatment programs. ( 28068951 )
2017
12
Orbito-frontal cortex volumes in patients with antisocial personality disorder. ( 28784365 )
2017
13
A Psychometric Evaluation of the DSM-IV Criteria for Antisocial Personality Disorder: Dimensionality, Local Reliability, and Differential Item Functioning Across Gender. ( 29284276 )
2017
14
A prospective, longitudinal, study of men with borderline personality disorder with and without comorbid antisocial personality disorder. ( 29225887 )
2017
15
More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder. ( 28810156 )
2017
16
An Adverse Family Environment During Adolescence Predicts Marijuana Use and Antisocial Personality Disorder in Adulthood. ( 27034610 )
2016
17
Impulsive lifestyle counseling to prevent dropout from treatment for substance use disorders in people with antisocial personality disorder: A randomized study. ( 26882500 )
2016
18
Modulatory effects of psychopathy on Wisconsin Card Sorting Test performance in male offenders with Antisocial Personality Disorder. ( 26708441 )
2016
19
Evidence for an agitated-aggressive syndrome in early-onset psychosis correlated with antisocial personality disorder, forensic history, and substance use disorder. ( 27117676 )
2016
20
Offenders With Antisocial Personality Disorder Display More Impairments in Mentalizing. ( 27064853 )
2016
21
Individual and Network Correlates of Antisocial Personality Disorder Among Rural Nonmedical Prescription Opioid Users. ( 27171488 )
2016
22
Genome-wide association study of antisocial personality disorder. ( 27598967 )
2016
23
Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment-seeking Young Adults. ( 27236178 )
2016
24
Comorbid trajectories of substance use as predictors of Antisocial Personality Disorder, Major Depressive Episode, and Generalized Anxiety Disorder. ( 27344118 )
2016
25
Examining the DSM-5 Alternative Personality Disorder Model Operationalization of Antisocial Personality Disorder and Psychopathy in a Male Correctional Sample. ( 26914324 )
2016
26
Reduced cortical thickness and increased surface area in antisocial personality disorder. ( 27600947 )
2016
27
The Relationship between Aggression and Serum Thyroid Hormone Level in Individuals Diagnosed with Antisocial Personality Disorder. ( 28360783 )
2016
28
Aberrant functional brain connectome in people with antisocial personality disorder. ( 27257047 )
2016
29
Psychopathy, Antisocial Personality Disorder, and Reconviction in an Australian Sample of Forensic Patients. ( 27288398 )
2016
30
Disrupted functional connectome in antisocial personality disorder. ( 27541949 )
2016
31
Neural Substrates of Antisocial Personality Disorder: Current State and Future Directions. ( 27776462 )
2016
32
A randomised controlled trial of mentalization-based treatment versus structured clinical management for patients with comorbid borderline personality disorder and antisocial personality disorder. ( 27577562 )
2016
33
Association of ventral striatum monoamine oxidase-A binding and functional connectivity in antisocial personality disorder with high impulsivity: A positron emission tomography and functional magnetic resonance imaging study. ( 26908392 )
2016
34
Experiential avoidance, empathy, and anger-related attitudesin antisocial personality disorder. ( 28081330 )
2016
35
Heightened early-attentional stimulus orienting and impulsive action in men with antisocial personality disorder. ( 27662886 )
2016
36
Facial emotion perception impairments in schizophrenia patients with comorbid antisocial personality disorder. ( 26778631 )
2016
37
Clinical differences between cocaine-dependent patients with and without antisocial personality disorder. ( 27839828 )
2016
38
Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [(11)C] Harmine Positron Emission Tomography Study. ( 26081301 )
2015
39
Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder. ( 25497297 )
2015
40
Effects of Intranasal Oxytocin on Aggressive Responding in Antisocial Personality Disorder. ( 27022201 )
2015
41
A longitudinal twin study of borderline and antisocial personality disorder traits in early to middle adulthood. ( 26050739 )
2015
42
"They're Really PD Today": An Exploration of Mental Health Nursing Students' Perceptions of Developing a Therapeutic Relationship With Patients With a Diagnosis of Antisocial Personality Disorder. ( 26169569 )
2015
43
Do people with borderline personality disorder complicated by antisocial personality disorder benefit from the STEPPS treatment program? ( 26671625 )
2015
44
Mindfulness moderates the relationship between aggression and Antisocial Personality Disorder traits: Preliminary investigation with an offender sample. ( 26350275 )
2015
45
The Natural History of Antisocial Personality Disorder. ( 26175389 )
2015
46
Gender differences in the clinical characteristics and psychiatric comorbidity in patients with antisocial personality disorder. ( 26296756 )
2015
47
The relationship between five-factor model and diagnostic and statistical manual of mental disorder-fifth edition personality traits on patients with antisocial personality disorder. ( 26487876 )
2015
48
Lifetime trauma victimization and PTSD in relation to psychopathy and antisocial personality disorder in a sample of incarcerated women and men. ( 26062658 )
2015
49
Psycho-education for substance use and antisocial personality disorder: a randomized trial. ( 26573140 )
2015
50
Co-occurring mental illness, substance use disorders, and antisocial personality disorder among clients of forensic mental health services. ( 25799303 )
2015

Variations for Antisocial Personality Disorder

Expression for Antisocial Personality Disorder

Search GEO for disease gene expression data for Antisocial Personality Disorder.

Pathways for Antisocial Personality Disorder

Pathways related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 ALDH2 COMT MAOA SLC6A3 SLC6A4 SNAP25
2
Show member pathways
12.5 COMT DRD2 MAOA MAOB SLC6A3
3
Show member pathways
11.97 ALDH2 MAOA MAOB
4 11.91 MAOA SLC6A4 SNAP25
5 11.74 MAOA MAOB SLC6A4
6
Show member pathways
11.69 DRD2 MAOA MAOB SLC6A3
7
Show member pathways
11.55 COMT MAOA MAOB
8
Show member pathways
11.41 ALDH2 MAOA MAOB
9
Show member pathways
11.29 MAOA MAOB
10
Show member pathways
11.27 MAOA SLC6A3 SLC6A4
11
Show member pathways
11.11 ALDH2 MAOA MAOB
12 11.07 MAOB SLC6A3
13 11 MAOA SLC6A4
14
Show member pathways
10.88 COMT MAOA
15 10.58 COMT MAOA MAOB
16
Show member pathways
10.45 ALDH2 MAOA MAOB
17
Show member pathways
10.44 ALDH2 COMT MAOA SLC6A3 SLC6A4
18
Show member pathways
10.43 ALDH2 COMT MAOA MAOB

GO Terms for Antisocial Personality Disorder

Cellular components related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.92 COMT DRD2 SLC6A3 SNAP25

Biological processes related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.65 DRD2 MAOB SLC6A3
2 response to toxic substance GO:0009636 9.63 DRD2 MAOB SLC6A4
3 neurotransmitter transport GO:0006836 9.59 SLC6A3 SLC6A4
4 response to nicotine GO:0035094 9.58 DRD2 SLC6A3
5 response to cocaine GO:0042220 9.58 DRD2 SLC6A3
6 locomotory behavior GO:0007626 9.58 DRD2 SLC6A3 SNAP25
7 positive regulation of multicellular organism growth GO:0040018 9.57 DRD2 SLC6A3
8 associative learning GO:0008306 9.56 DRD2 SNAP25
9 response to iron ion GO:0010039 9.55 DRD2 SLC6A3
10 response to drug GO:0042493 9.55 COMT DRD2 MAOB SLC6A3 SLC6A4
11 dopamine metabolic process GO:0042417 9.54 COMT DRD2
12 neurotransmitter biosynthetic process GO:0042136 9.52 SLC6A3 SLC6A4
13 ammonium transmembrane transport GO:0072488 9.51 SLC6A3 SLC6A4
14 prepulse inhibition GO:0060134 9.49 DRD2 SLC6A3
15 catecholamine metabolic process GO:0006584 9.43 COMT MAOA
16 adenohypophysis development GO:0021984 9.37 DRD2 SLC6A3
17 monoamine transport GO:0015844 9.32 SLC6A3 SLC6A4
18 dopamine uptake involved in synaptic transmission GO:0051583 9.26 SLC6A3 SLC6A4
19 neurotransmitter catabolic process GO:0042135 9.13 COMT MAOA MAOB
20 dopamine catabolic process GO:0042420 8.92 COMT MAOA MAOB SLC6A3

Molecular functions related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 syntaxin-1 binding GO:0017075 9.37 SLC6A4 SNAP25
2 neurotransmitter:sodium symporter activity GO:0005328 9.32 SLC6A3 SLC6A4
3 dopamine binding GO:0035240 9.26 DRD2 SLC6A3
4 monoamine transmembrane transporter activity GO:0008504 9.16 SLC6A3 SLC6A4
5 primary amine oxidase activity GO:0008131 8.96 MAOA MAOB
6 dopamine:sodium symporter activity GO:0005330 8.62 SLC6A3 SLC6A4

Sources for Antisocial Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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