ASP
MCID: ANT011
MIFTS: 55

Antisocial Personality Disorder (ASP) malady

Neuronal category

Summaries for Antisocial Personality Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.

MalaCards: Antisocial Personality Disorder, also known as psychopathic personality disorder, is related to substance abuse and conduct disorder. An important gene associated with Antisocial Personality Disorder is MAOA (monoamine oxidase A), and among its related pathways are Enzymatic degradation of dopamine by COMT and melatonin degradation II. The compounds p-chloroamphetamine and minaprine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and prefrontal cortex, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Wikipedia:64 Antisocial (or dissocial) personality disorder is a personality disorder characterized by a pervasive... more...

Aliases & Classifications for Antisocial Personality Disorder

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

antisocial personality disorder 8 43 10 45 61
psychopathic personality disorder 8
dissocial personality disorder 8
psychopathic personality 8
sociopathic personality 8
psychopath.personality 8
asocial personality 8
asp 43


External Ids:

Disease Ontology8 DOID:10939
MeSH35 D000987
ICD9CM27 301.7
ICD1025 F60.2

Related Diseases for Antisocial Personality Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Antisocial Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1substance abuse31.3DRD2, SLC6A3, SLC6A4, ALDH2
2conduct disorder31.2COMT, DRD2, MAOA, TTF2, SLC6A3, SLC6A4
3borderline personality disorder31.0HTR1B, MAOA, TTF2, SLC6A4
4anxiety disorder30.9SLC6A4, MAOA
5alcohol dependence30.8DRD2, GABRA6, ANKK1, MAOA, SLC6A4, ALDH2
6substance dependence30.7COMT, DRD2, SLC6A3, SLC6A4
7alcohol abuse30.7COMT, DRD2, SLC6A3, SLC6A4, ALDH2
8pathological gambling30.6DRD2, SLC6A3
9cocaine dependence30.5DRD2, SLC6A3, SLC6A4
10bipolar disorder30.5HTR2A, DRD2, SLC6A4
11attention deficit hyperactivity disorder30.5SLC6A4, SLC6A3, MAOA, COMT, HTR1B, HTR2A
12alexithymia30.3ANKK1
13cocaine abuse30.3DRD2, SLC6A3, SLC6A4
14bulimia nervosa30.3COMT, HTR1B, HTR2A, MAOA, SLC6A4
15dependent personality disorder10.8
16thalassemia10.5
17alpha thalassemia10.5
18beta thalassemia10.5
19sleep disorder10.4
20aspergillosis10.4
21alveolar soft part sarcoma10.4
22somatization disorder10.4
23sexual sadism10.4
24bipolar i disorder10.4
25allergic bronchopulmonary aspergillosis10.3
26coronary artery disease,10.3
27narcissistic personality disorder10.2
28histrionic personality disorder10.2
29mental retardation10.2
30canavan disease10.1
31hypophosphatasia10.1
32delta-beta thalassemia10.1
33thalassemia, delta-10.1
34hemoglobin c - beta-thalassemia10.1
35stroke, ischemic10.0
36t-cell leukemia10.0
37angel shaped phalangoepiphyseal dysplasia10.0
38hemoglobin so10.0
39insulin resistance10.0
40hyperapobetalipoproteinemia10.0
41restless legs syndrome10.0DRD2
42hypertension10.0SLC6A4
43melancholia10.0MAOA
44premature ejaculation10.0SLC6A4
45alcoholic psychosis10.0SLC6A4
46neuroleptic malignant syndrome10.0DRD2
47irritable bowel syndrome10.0SLC6A4
48diabetes mellitus10.0ALDH2
49blindness10.0MAOB
50chronic fatigue syndrome10.0MAOA, SLC6A4

Graphical network of the top 20 diseases related to Antisocial Personality Disorder:



Diseases related to antisocial personality disorder

Clinical Features for Antisocial Personality Disorder

Drugs & Therapeutics for Antisocial Personality Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Antisocial Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Antisocial Personality Disorder

Search NIH Clinical Center for Antisocial Personality Disorder

Search CenterWatch for Antisocial Personality Disorder

Genetic Tests for Antisocial Personality Disorder

Anatomical Context for Antisocial Personality Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Antisocial Personality Disorder:

33
Brain, Cortex, Prefrontal cortex, Cingulate cortex, Temporal lobe

Animal Models for Antisocial Personality Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Antisocial Personality Disorder

Sources:
51PubMed
See all sources

Articles related to Antisocial Personality Disorder:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
The role of fearless dominance in differentiating psychopathy from antisocial personality disorder: comment on Marcus, Fulton, and Edens. (23339316)
2013
2
Reduced thalamic volume in men with antisocial personality disorder or schizophrenia and a history of serious violence and childhood abuse. (22944337)
2013
3
Differentiating psychopathy from antisocial personality disorder: a triarchic model perspective. (23834781)
2013
4
White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder. (21777912)
2012
5
Association of COL25A1 with comorbid antisocial personality disorder and substance dependence. (22297151)
2012
6
Diagnosis of antisocial personality disorder and criminal responsibility. (21903271)
2011
7
Multivariate dependencies between difficult childhood, temperament and antisocial personality disorder in a population of French male prisoners. (21600716)
2011
8
5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder. (21399568)
2011
9
Heavy episodic drinking in college students: associations with features of psychopathy and antisocial personality disorder. (21500054)
2011
10
Antisocial personality disorder is on a continuum with psychopathy. (20579518)
2010
11
Diagnosis and subtypes of adolescent antisocial personality disorder. (20420477)
2010
12
Neurodevelopmental marker for limbic maldevelopment in antisocial personality disorder and psychopathy. (20807962)
2010
13
Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. (20175604)
2010
14
Psychological interventions for antisocial personality disorder. (20556783)
2010
15
Interactions between bipolar disorder and antisocial personality disorder in trait impulsivity and severity of illness. (20064125)
2010
16
Gender differences in autonomic indicators of antisocial personality disorder features. (22448620)
2010
17
MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (19302089)
2009
18
A pilot study revealing impaired P50 gating in antisocial personality disorder. (19776314)
2009
19
Developmental epidemiological courses leading to antisocial personality disorder and violent and criminal behavior: effects by young adulthood of a universal preventive intervention in first- and second-grade classrooms. (18243581)
2008
20
The interactive effects of antisocial personality disorder and court-mandated status on substance abuse treatment dropout. (17869050)
2008
21
DSM-IV conduct disorder criteria as predictors of antisocial personality disorder. (17954138)
2007
22
Antisocial personality disorder in older adults. A qualitative study of Dutch forensic psychiatrists and forensic psychologists. (17295198)
2007
23
Psychopathy/antisocial personality disorder conundrum. (16756576)
2006
24
Is antisocial personality disorder continuous or categorical? A taxometric analysis. (16836795)
2006
25
Substance use disorders in men with antisocial personality disorder: a study in Turkish sample. (16798683)
2006
26
Association of antisocial personality disorder and substance disorder morbidity in a clinical sample. (15768573)
2005
27
The correlates of comorbid antisocial personality disorder in schizophrenia. (15954191)
2004
28
Predicting borderline and antisocial personality disorder features in nonclinical subjects using measures of impulsivity and aggressiveness. (15006439)
2004
29
Presentation of antisocial personality disorder: mounting evidence on optimal timing and methods. (15188017)
2004
30
Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. (12824808)
2003
31
Assessing suicidal youth with antisocial, borderline, or narcissistic personality disorder. (12866335)
2003
32
Treating impulsivity, irritability, and aggression of antisocial personality disorder with quetiapine. (14526596)
2003
33
Early identification of individuals at risk for antisocial personality disorder. (12509302)
2003
34
Evidence in an international sample of alcohol-dependent subjects of subgroups with specific symptom patterns of antisocial personality disorder. (12170119)
2002
35
Antisocial personality disorder and TC treatment outcomes. (12014812)
2002
36
Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism. (12036509)
2002
37
Sex differences in psychopathy and antisocial personality disorder. A review and integration. (12436810)
2002
38
Antisocial personality disorder, alcohol, and aggression. (11496966)
2001
39
A latent class analysis of antisocial personality disorder symptom data from a multi-centre family study of alcoholism. (10829331)
2000
40
Prognostic significance of antisocial personality disorder in cocaine-dependent patients entering continuing care. (10830566)
2000
41
Who should take responsibility for antisocial personality disorder? Fallon suggests emphasising custody, but psychiatrists' future role remains unclear. (9915708)
1999
42
Gender and drug differences in antisocial personality disorder. (9169384)
1997
43
Reduced P3 amplitudes are associated with both a family history of alcoholism and antisocial personality disorder. (7863018)
1994
44
Desipramine treatment for cocaine dependence. Role of antisocial personality disorder. (8113775)
1994
45
Attribution of antisocial symptoms in coexistent antisocial personality disorder and substance abuse. (8348801)
1993
46
Rethinking the DSM III-R diagnosis of antisocial personality disorder. (2039844)
1991
47
Psychopathy and the DSM-IV criteria for antisocial personality disorder. (1918618)
1991
48
The antisocial personality disorder diagnosis. (2386266)
1990
49
Childhood identification and prophylaxis of antisocial personality disorder. (3280731)
1988
50
Mad or bad? some clinical considerations in the misdiagnosis of schizophrenia as antisocial personality disorder. (7124989)
1982

Genetic Variations for Antisocial Personality Disorder

Expression for genes affiliated with Antisocial Personality Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Antisocial Personality Disorder

Search GEO for disease gene expression data for Antisocial Personality Disorder.

Pathways for genes affiliated with Antisocial Personality Disorder

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7ALDH2, SLC6A3, MAOA
2
Hide members
9.6ALDH2, MAOB, MAOA
3
Hide members
9.6ALDH2, MAOB, MAOA
49.6ALDH2, MAOB, MAOA
59.6MAOA, MAOB, ALDH2
6
Hide members
9.6MAOA, MAOB, ALDH2
7
Hide members
9.5COMT, MAOA, MAOB
8
Hide members
9.5COMT, MAOA, MAOB
9
Tyrosine metabolism p.1 (dopamine)
Hide members
9.5MAOB, MAOA, COMT
109.4DRD2, MAOA, MAOB, SLC6A3
11
Hide members
9.4DRD2, MAOA, MAOB, SLC6A3
12
Hide members
9.2HTR1B, HTR2A, DRD2, MAOA, SLC6A4
13
Hide members
9.2ALDH2, MAOB, MAOA, COMT
148.9HTR2A, SNAP25, MAOA, SLC6A4
15
Hide members
8.4HTR1B, HTR2A, DRD2, GABRB2, GABRA6, PRL
16
Hide members
7.6COMT, GABRB2, GABRA6, SNAP25, MAOA, SLC6A3
17
Hide members
7.3SLC6A4, COMT, HTR1B, HTR2A, DRD2, GABRB2

Compounds for genes affiliated with Antisocial Personality Disorder

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 283)
idCompoundScoreTop Affiliating Genes
1p-chloroamphetamine459.7SLC6A4, SLC6A3, MAOB, MAOA
2minaprine45 1110.7SLC6A4, MAOA, DRD2, HTR2A
3phentermine45 1110.7SLC6A4, SLC6A3, MAOB, MAOA
44-Methoxyamphetamine119.7SLC6A4, SLC6A3, MAOB, MAOA
5d amphetamine459.5DRD2, MAOA, MAOB, SLC6A3, SLC6A4
6mcpp459.5SLC6A4, HTR1B, HTR2A, PRL
7MMDA119.5MAOB, HTR2A, MAOA, SLC6A4, SLC6A3
8Ephedra119.5SLC6A4, SLC6A3, MAOA, MAOB
9venlafaxine50 45 11 2412.5SLC6A4, SLC6A3, HTR2A, HTR1B, GABRA6
10pindolol45 29 1111.4SLC6A4, HTR1B, PRL, HTR2A
11clomipramine45 50 1111.4MAOA, HTR2A, SLC6A3, SLC6A4, PRL
12amoxapine45 29 1111.4SLC6A4, PRL, DRD2, HTR2A
13trimipramine50 45 1111.4SLC6A4, HTR2A, DRD2, PRL, SLC6A3
14mdma459.3PRL, MAOA, MAOB, SLC6A3, SLC6A4
15amitriptyline45 50 29 1112.3MAOA, SLC6A4, MAOB, SLC6A3, HTR2A
16tyramine45 29 2411.3COMT, SLC6A4, SLC6A3, MAOB, MAOA
17terguride29 4510.3PRL, HTR1B, HTR2A, DRD2
18ropinirole45 1110.3HTR1B, HTR2A, MAOB, DRD2, COMT
19sertindole29 45 1111.2PRL, DRD2, HTR2A, HTR1B
20quetiapine45 50 29 11 2413.2HTR2A, SLC6A3, HTR1B, DRD2, PRL
21pergolide29 45 1111.2HTR1B, HTR2A, DRD2, PRL, COMT
22carbidopa45 2910.2SLC6A3, MAOB, COMT, PRL
23cabergoline29 45 1111.2HTR1B, PRL, COMT, DRD2, HTR2A
24mhpg459.2MAOA, MAOB, SLC6A4, COMT, PRL
25methylphenidate45 50 1111.2COMT, DRD2, MAOA, MAOB, SLC6A3, SLC6A4
26amphetamine45 1110.1SLC6A4, SLC6A3, DRD2, MAOA, MAOB
27homovanillic acid45 2410.1MAOA, COMT, PRL, MAOB, SLC6A4
28methamphetamine45 50 1111.1SLC6A4, MAOB, MAOA, DRD2, COMT, SLC6A3
29mptp459.1SLC6A3, SLC6A4, COMT, MAOA, DRD2, MAOB
30citalopram50 45 11 2412.0SLC6A4, SLC6A3, HTR2A, PRL, MAOA, MAOB
31bupropion45 50 11 2412.0COMT, DRD2, ANKK1, MAOB, SLC6A3, SLC6A4
32pramipexole45 50 29 1112.0COMT, HTR2A, HTR1B, PRL, SLC6A3, DRD2
33bromocriptine29 45 1111.0HTR1B, SLC6A3, PRL, DRD2, HTR2A, COMT
34ritanserin29 459.9PRL, HTR1B, DRD2, HTR2A
35haloperidol45 29 2 50 1112.9DRD2, PRL, MAOB, SLC6A3, SLC6A4, HTR2A
366-hydroxydopamine458.9DRD2, COMT, SLC6A3, MAOB, MAOA
37paroxetine45 50 29 1111.8HTR2A, COMT, HTR1B, PRL, SLC6A4, SLC6A3
38olanzapine50 45 29 11 2412.7HTR1B, SLC6A3, HTR2A, DRD2, PRL, ANKK1
39levodopa45 119.7COMT, HTR1B, MAOB, DRD2, SLC6A3, MAOA
40maoa458.7HTR1B, MAOB, HTR2A, DRD2, MAOA, SLC6A3
41apomorphine45 29 1110.7MAOB, PRL, COMT, DRD2, HTR1B, HTR2A
42cocaine45 119.6SLC6A4, SLC6A3, MAOB, DRD2, PRL, HTR1B
43fluoxetine50 45 29 1111.6SLC6A4, SLC6A3, MAOB, MAOA, PRL, DRD2
44nicotine45 50 29 1111.6SLC6A3, TTF2, DRD2, ANKK1, COMT, MAOA
45risperidone29 45 50 60 11 2413.5COMT, SLC6A4, SLC6A3, ANKK1, PRL, DRD2
46clozapine45 29 50 1111.5DRD2, PRL, ANKK1, SLC6A3, SLC6A4, HTR2A
47gaba458.2GABRA6, SNAP25, MAOA, MAOB, SLC6A3, SLC6A4
485-hydroxytryptamine458.2PRL, MAOA, MAOB, SLC6A4, DRD2, HTR2A
49norepinephrine45 11 249.6COMT, SLC6A3, HTR2A, SLC6A4, DRD2, SNAP25
50dopamine45 29 11 2410.1SLC6A3, SLC6A4, MAOB, MAOA, PRL, ALDH2

GO Terms for genes affiliated with Antisocial Personality Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058877.5SLC6A4, COL25A1, HTR1B, HTR2A, DRD2, GABRB2
2plasma membraneGO:0058866.6COMT, HTR1B, HTR2A, DRD2, GABRB2, GABRA6

Biological processes related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1monoamine transportGO:01584410.2SLC6A3, SLC6A4
2adenohypophysis developmentGO:02198410.2SLC6A3, DRD2
3G-protein coupled receptor internalizationGO:00203110.1DRD2, HTR1B
4negative regulation of serotonin secretionGO:01406310.1MAOB, HTR1B
5response to iron ionGO:01003910.1SLC6A3, DRD2
6neurotransmitter catabolic processGO:04213510.1MAOA, COMT
7regulation of behaviorGO:05079510.0HTR2A, HTR1B
8response to cocaineGO:04222010.0HTR1B, DRD2, SLC6A3
9negative regulation of synaptic transmission, glutamatergicGO:05196710.0DRD2, HTR2A, HTR1B
10regulation of dopamine secretionGO:01405910.0HTR1B, HTR2A, DRD2
11vasoconstrictionGO:04231010.0SLC6A4, HTR1B
12prepulse inhibitionGO:06013410.0DRD2, SLC6A3
13dopamine catabolic processGO:0424209.9SLC6A3, MAOA, COMT
14response to toxic substanceGO:0096369.8DRD2, MAOB, SLC6A4
15temperature homeostasisGO:0016599.6DRD2, HTR2A
16neurotransmitter biosynthetic processGO:0421369.6COMT, MAOA, SLC6A3, ALDH2
17response to ethanolGO:0454719.5SLC6A3, MAOB, PRL, HTR1B
18xenobiotic metabolic processGO:0068059.4ALDH2, MAOB, MAOA, COMT
19response to lipopolysaccharideGO:0324969.1MAOB, PRL, COMT
20response to drugGO:0424938.5COMT, HTR2A, DRD2, PRL, MAOB, SLC6A3
21synaptic transmissionGO:0072687.4ALDH2, COMT, HTR1B, HTR2A, GABRB2, GABRA6

Molecular functions related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.0SLC6A4, SLC6A3
2primary amine oxidase activityGO:0081319.9MAOA, MAOB
3serotonin bindingGO:0513789.9HTR2A, HTR1B
4dopamine bindingGO:0352409.7SLC6A3, DRD2
5GABA-A receptor activityGO:0048909.6GABRA6, GABRB2
6drug bindingGO:0081449.6SLC6A3, DRD2, HTR2A, HTR1B

Products for genes affiliated with Antisocial Personality Disorder

  • Antibodies
  • Proteins
  • Lysates
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Sources for Antisocial Personality Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet