MCID: ANT011
MIFTS: 47

Antisocial Personality Disorder malady

Categories: Mental diseases

Aliases & Classifications for Antisocial Personality Disorder

Aliases & Descriptions for Antisocial Personality Disorder:

Name: Antisocial Personality Disorder 12 52 42 14 69
Psychopathic Personality Disorder 12
Dissocial Personality Disorder 12
Psychopathic Personality 12
Sociopathic Personality 12
Psychopath.personality 12
Asocial Personality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10939
ICD10 33 F60.2
ICD9CM 35 301.7
MeSH 42 D000987
NCIt 47 C88413
UMLS 69 C0003431

Summaries for Antisocial Personality Disorder

Disease Ontology : 12 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.

MalaCards based summary : Antisocial Personality Disorder, also known as psychopathic personality disorder, is related to personality disorder and schizophrenia. An important gene associated with Antisocial Personality Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Transmission across Chemical Synapses and Circadian entrainment. The drugs Naratriptan and Vasoconstrictor Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 71 Antisocial personality disorder (ASPD), also known as dissocial personality disorder (DPD) and... more...

Related Diseases for Antisocial Personality Disorder

Diseases related to Antisocial Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 personality disorder 31.1 ALDH2 COMT DRD2 MAOA SLC6A3 SLC6A4
2 schizophrenia 29.2 ANKK1 COMT DRD2 MAOA MAOB SLC6A3
3 conduct disorder 11.3
4 impulse control disorder 10.9
5 substance abuse 10.4
6 cocaine dependence 10.3
7 alcohol dependence 10.2
8 neurogenic bladder 10.2 MAOA SLC6A4
9 adult brainstem astrocytoma 10.2 MAOA SLC6A4
10 substance dependence 10.2
11 anodontia 10.2 SLC6A3 SLC6A4
12 kidney pelvis papillary carcinoma 10.2 MAOA SLC6A4
13 euthyroid sick syndrome 10.2 DRD2 SLC6A4
14 anxiety disorder 10.2
15 cholestasis-lymphedema syndrome 10.2 COMT MAOA
16 nephronophthisis 13 10.2 COMT SLC6A4
17 waardenburg's syndrome 10.2 DRD2 SLC6A4
18 tinea pedis 10.2 MAOA SLC6A3 SLC6A4
19 intracranial aneurysm 10.1 ANKK1 DRD2
20 borderline personality disorder 10.1
21 heroin dependence 10.1
22 rhinoscleroma 10.1 COMT DRD2
23 scoliosis 10.1 DRD2 SLC6A3
24 ornithosis 10.1 DRD2 MAOA SLC6A4
25 rectosigmoid junction neoplasm 10.1 DRD2 SLC6A3
26 postencephalitic parkinson disease 10.1 DRD2 MAOA SLC6A4
27 intracranial cavernous angioma 10.1 DRD2 SLC6A3 SLC6A4
28 splenic abscess 10.1 DRD2 SLC6A3 SLC6A4
29 transmitted_by 10.1 DRD2 SLC6A3 SLC6A4
30 microcephaly 13, primary, autosomal recessive 10.1 DRD2 MAOA SLC6A4
31 c8 deficiency, type ii 10.1 COMT DRD2
32 renpenning syndrome 10.1 COMT MAOA SLC6A4
33 intrahepatic gall duct cancer 10.1 COMT MAOA SLC6A4
34 chronic eosinophilic pneumonia 10.1 COMT MAOA SLC6A4
35 multiple personality disorder 10.1 COMT MAOA SLC6A4
36 interstitial emphysema 10.1 DRD2 SLC6A4
37 keratosis 10.1 COMT MAOA SLC6A4
38 lichen disease 10.1 COMT MAOA SLC6A4
39 fechtner syndrome 10.1 COMT MAOA SLC6A4
40 18p deletion syndrome 10.1 ANKK1 DRD2 SLC6A3
41 hypoglycemia 10.1 ANKK1 DRD2 SLC6A4
42 autism spectrum disorder 10.0 COMT SLC6A3 SLC6A4
43 urea cycle disorder 10.0 COMT DRD2
44 dissociative disorder 10.0 MAOA MAOB
45 tuberculoid leprosy 10.0 MAOA MAOB
46 aortic valve disease 2 10.0 COMT DRD2 SLC6A3
47 mucinous adenocarcinoma 10.0 DRD2 MAOA SLC6A3 SLC6A4
48 hypoglycemic coma 10.0 MAOA SLC6A4
49 hypereosinophilic syndrome 10.0 DRD2 MAOA SLC6A3 SLC6A4
50 parotid gland cancer 10.0 COMT DRD2 SLC6A3

Comorbidity relations with Antisocial Personality Disorder via Phenotypic Disease Network (PDN):


Schizophreniform Disorder

Graphical network of the top 20 diseases related to Antisocial Personality Disorder:



Diseases related to Antisocial Personality Disorder

Symptoms & Phenotypes for Antisocial Personality Disorder

MGI Mouse Phenotypes related to Antisocial Personality Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ALDH2 COL25A1 COMT DRD2 MAOA MAOB
2 homeostasis/metabolism MP:0005376 9.91 ALDH2 COL25A1 COMT DRD2 MAOA MAOB
3 endocrine/exocrine gland MP:0005379 9.8 ALDH2 COMT DRD2 SLC6A3 SLC6A4 SNAP25
4 nervous system MP:0003631 9.61 COMT DRD2 MAOA MAOB SLC6A3 SLC6A4
5 muscle MP:0005369 9.55 SNAP25 COL25A1 DRD2 SLC6A3 SLC6A4
6 taste/olfaction MP:0005394 8.8 DRD2 SLC6A3 SNAP25

Drugs & Therapeutics for Antisocial Personality Disorder

Drugs for Antisocial Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naratriptan Approved, Investigational Phase 4 143388-64-1, 121679-13-8 4440
2 Vasoconstrictor Agents Phase 4,Phase 2
3 Neurotransmitter Agents Phase 4
4
Serotonin Phase 4 50-67-9 5202
5 Serotonin 5-HT1 Receptor Agonists Phase 4
6 Serotonin Agents Phase 4
7
Ethanol Approved Phase 2, Phase 3 64-17-5 702
8 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3
9 Arginine Vasopressin Phase 2
10 Coagulants Phase 2
11 Hemostatics Phase 2
12 Natriuretic Agents Phase 2
13 Vasopressins Phase 2
14 arginine Nutraceutical Phase 2
15
Guanfacine Approved, Investigational 29110-47-2 3519
16
Norepinephrine Approved 51-41-2 439260
17
Yohimbine Approved, Vet_approved 146-48-5 8969
18
Dopamine Approved 51-61-6, 62-31-7 681
19
Morphine Approved, Investigational 57-27-2 5288826
20 Adrenergic Agents
21 Adrenergic Agonists
22 Adrenergic alpha-Agonists
23 Autonomic Agents
24 Peripheral Nervous System Agents
25 Central Nervous System Stimulants
26 Dopamine Agents
27 Dopamine Uptake Inhibitors
28 Lisdexamfetamine Dimesylate
29 Neurotransmitter Uptake Inhibitors
30 Anti-Infective Agents
31 Anti-Infective Agents, Local
32 Central Nervous System Depressants
33 Detox adjuvant
34
Silicon 7440-21-3 4082203
35 Yohimbe Nutraceutical

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA) Completed NCT00000388 Phase 4
2 Efficacy of a Triptan in the Treatment of Hostility and Aggression Among Convicts With a Psychiatric Treatment Order Terminated NCT00282165 Phase 4
3 Effect of Omega-3 Supplementation on Child Behavior Problems Completed NCT02016079 Phase 2, Phase 3
4 Personality-targeted Interventions for Adolescent Alcohol Misuse Completed NCT00344474 Phase 2, Phase 3
5 Vasopressin Effects on Human Social Communication Unknown status NCT01327027 Phase 2
6 The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention Completed NCT01532934 Phase 2
7 Working Memory Training in Adults With Substance Abuse and Executive Function Deficits. Recruiting NCT02068261 Phase 2
8 Antisocial Behavior: Passing From Parent to Child to Grandchild Unknown status NCT00060788
9 Mental Health Related to School Dropout in Luxembourg Unknown status NCT01354236
10 Conduct Disorder in Prison: Search for Prospective and Retrospective Recurring and Contextual Elements Completed NCT02493088
11 Matching Cognitive Remediation to Cognitive Deficits in Substance-Abusing Inmates Completed NCT01428349
12 Impaired Decision-making in Adolescents Completed NCT01253993 Early Phase 1
13 The Role of Norepinephrine in Emotional Processing Completed NCT00109642
14 Early Exposure to Lead and Adult Antisocial Outcomes Completed NCT00285610
15 To Evaluate the Safety and Metabolic Profile of Vyvanse for the Treatment of ADHD in Euthymic Adults With Bipolar I/II Disorder Completed NCT01263548
16 Psychological Mechanisms of Behavioral Dysregulation Completed NCT00352456
17 Study of Children at Risk for Disruptive Behavior Disorders Completed NCT00001233
18 Justice-Involved Veterans and Moral Reconation Therapy Recruiting NCT02524171
19 Multisystemic Therapy-Emerging Adults Trial Recruiting NCT02922335
20 The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior Recruiting NCT02427672
21 ADHD: Gaps Between Patients With Alcohol-dependence and Impact on Relapse Recruiting NCT02364817
22 Mentalization-based Training for Adolescents With Conduct Disorder (MBT-CD) Recruiting NCT02988453
23 Personality Pathology and Cerebral Processing in Eating Disorders Recruiting NCT02980120
24 The Effect of Repeated Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior Active, not recruiting NCT02674516
25 Multisite Prevention of Conduct Problems (Fast Track) Active, not recruiting NCT01653535
26 Psychobiological Effects of Meditation on Offenders With Psychopathy Not yet recruiting NCT02894203
27 Multisystemic Therapy-Emerging Adults (MST-EA) for Substance Abuse Not yet recruiting NCT03035877
28 Role of Oxytocin in Telling and Detecting Lies Withdrawn NCT02361177 Early Phase 1

Search NIH Clinical Center for Antisocial Personality Disorder

Cochrane evidence based reviews: antisocial personality disorder

Genetic Tests for Antisocial Personality Disorder

Anatomical Context for Antisocial Personality Disorder

MalaCards organs/tissues related to Antisocial Personality Disorder:

39
Brain, Testes, Eye, Cortex, Prefrontal Cortex

Publications for Antisocial Personality Disorder

Articles related to Antisocial Personality Disorder:

(show top 50) (show all 364)
id Title Authors Year
1
Did you get any help? A post-hoc secondary analysis of a randomized controlled trial of psychoeducation for patients with antisocial personality disorder in outpatient substance abuse treatment programs. ( 28068951 )
2017
2
Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment-seeking Young Adults. ( 27236178 )
2016
3
Genome-wide association study of antisocial personality disorder. ( 27598967 )
2016
4
Modulatory effects of psychopathy on Wisconsin Card Sorting Test performance in male offenders with Antisocial Personality Disorder. ( 26708441 )
2016
5
Psychopathy, Antisocial Personality Disorder, and Reconviction in an Australian Sample of Forensic Patients. ( 27288398 )
2016
6
Facial emotion perception impairments in schizophrenia patients with comorbid antisocial personality disorder. ( 26778631 )
2016
7
Association of ventral striatum monoamine oxidase-A binding and functional connectivity in antisocial personality disorder with high impulsivity: A positron emission tomography and functional magnetic resonance imaging study. ( 26908392 )
2016
8
Experiential avoidance, empathy, and anger-related attitudesin antisocial personality disorder. ( 28081330 )
2016
9
Evidence for an agitated-aggressive syndrome in early-onset psychosis correlated with antisocial personality disorder, forensic history, and substance use disorder. ( 27117676 )
2016
10
Impulsive lifestyle counseling to prevent dropout from treatment for substance use disorders in people with antisocial personality disorder: A randomized study. ( 26882500 )
2016
11
Individual and Network Correlates of Antisocial Personality Disorder Among Rural Nonmedical Prescription Opioid Users. ( 27171488 )
2016
12
Neural Substrates of Antisocial Personality Disorder: Current State and Future Directions. ( 27776462 )
2016
13
Clinical differences between cocaine-dependent patients with and without antisocial personality disorder. ( 27839828 )
2016
14
An Adverse Family Environment During Adolescence Predicts Marijuana Use and Antisocial Personality Disorder in Adulthood. ( 27034610 )
2016
15
Heightened early-attentional stimulus orienting and impulsive action in men with antisocial personality disorder. ( 27662886 )
2016
16
Examining the DSM-5 Alternative Personality Disorder Model Operationalization of Antisocial Personality Disorder and Psychopathy in a Male Correctional Sample. ( 26914324 )
2016
17
Comorbid trajectories of substance use as predictors of Antisocial Personality Disorder, Major Depressive Episode, and Generalized Anxiety Disorder. ( 27344118 )
2016
18
Aberrant functional brain connectome in people with antisocial personality disorder. ( 27257047 )
2016
19
A randomised controlled trial of mentalization-based treatment versus structured clinical management for patients with comorbid borderline personality disorder and antisocial personality disorder. ( 27577562 )
2016
20
Reduced cortical thickness and increased surface area in antisocial personality disorder. ( 27600947 )
2016
21
Offenders With Antisocial Personality Disorder Display More Impairments in Mentalizing. ( 27064853 )
2016
22
Disrupted functional connectome in antisocial personality disorder. ( 27541949 )
2016
23
Possible role of a dysregulation of the endogenous opioid system in antisocial personality disorder. ( 26250442 )
2015
24
Lifetime trauma victimization and PTSD in relation to psychopathy and antisocial personality disorder in a sample of incarcerated women and men. ( 26062658 )
2015
25
Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [(11)C] Harmine Positron Emission Tomography Study. ( 26081301 )
2015
26
Psycho-education for substance use and antisocial personality disorder: a randomized trial. ( 26573140 )
2015
27
Do people with borderline personality disorder complicated by antisocial personality disorder benefit from the STEPPS treatment program? ( 26671625 )
2015
28
The Natural History of Antisocial Personality Disorder. ( 26175389 )
2015
29
Gender differences in the clinical characteristics and psychiatric comorbidity in patients with antisocial personality disorder. ( 26296756 )
2015
30
The relationship between five-factor model and diagnostic and statistical manual of mental disorder-fifth edition personality traits on patients with antisocial personality disorder. ( 26487876 )
2015
31
Mindfulness moderates the relationship between aggression and Antisocial Personality Disorder traits: Preliminary investigation with an offender sample. ( 26350275 )
2015
32
Co-occurring mental illness, substance use disorders, and antisocial personality disorder among clients of forensic mental health services. ( 25799303 )
2015
33
A longitudinal twin study of borderline and antisocial personality disorder traits in early to middle adulthood. ( 26050739 )
2015
34
"They're Really PD Today": An Exploration of Mental Health Nursing Students' Perceptions of Developing a Therapeutic Relationship With Patients With a Diagnosis of Antisocial Personality Disorder. ( 26169569 )
2015
35
Effects of Intranasal Oxytocin on Aggressive Responding in Antisocial Personality Disorder. ( 27022201 )
2015
36
Epidemiology, Comorbidity, and Behavioral Genetics of Antisocial Personality Disorder and Psychopathy. ( 26594067 )
2015
37
Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder. ( 25497297 )
2015
38
Antisocial Personality Disorder and Pathological Narcissism in Prolonged Conflicts and Wars of the 21st Century. ( 26456397 )
2015
39
Examining the Role of Antisocial Personality Disorder in Intimate Partner Violence Among Substance Use Disorder Treatment Seekers With Clinically Significant Trauma Histories. ( 26084544 )
2015
40
Associations between Antisocial Personality Disorder and Sex on Discounting Rates. ( 25364042 )
2014
41
The validity and clinical utility of structured diagnoses of antisocial personality disorder with forensic patients. ( 24511901 )
2014
42
Comparing the Utility of DSM-5 Section II and III Antisocial Personality Disorder Diagnostic Approaches for Capturing Psychopathic Traits. ( 25364943 )
2014
43
Lower anterior cingulate volume in seriously violent men with antisocial personality disorder or schizophrenia and a history of childhood abuse. ( 24234836 )
2014
44
Examining the associations between DSM-5 section III antisocial personality disorder traits and psychopathy in community and university samples. ( 24689766 )
2014
45
Prevalence of antisocial personality disorder among Chinese individuals receiving treatment for heroin dependence: a meta-analysis. ( 25477719 )
2014
46
DSM-IV antisocial personality disorder and conduct disorder: evidence for taxonic structures among individuals with and without substance use disorders in the general population. ( 24766762 )
2014
47
The social construction of violence among Northern Plains tribal members with antisocial personality disorder and alcohol use disorder. ( 24045407 )
2014
48
Clozapine: an effective treatment for seriously violent and psychopathic men with antisocial personality disorder in a UK high-security hospital. ( 24698103 )
2014
49
Physiological correlates of psychopathy, antisocial personality disorder, habitual aggression, and violence. ( 25129139 )
2014
50
Changes in low-frequency fluctuations in patients with antisocial personality disorder revealed by resting-state functional MRI. ( 24598769 )
2014

Variations for Antisocial Personality Disorder

Expression for Antisocial Personality Disorder

Search GEO for disease gene expression data for Antisocial Personality Disorder.

Pathways for Antisocial Personality Disorder

Pathways related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 ALDH2 COMT MAOA SLC6A3 SLC6A4 SNAP25
2
Show member pathways
12.5 COMT DRD2 MAOA MAOB SLC6A3
3
Show member pathways
11.97 ALDH2 MAOA MAOB
4 11.91 MAOA SLC6A4 SNAP25
5 11.74 MAOA MAOB SLC6A4
6
Show member pathways
11.69 DRD2 MAOA MAOB SLC6A3
7
Show member pathways
11.55 COMT MAOA MAOB
8
Show member pathways
11.41 ALDH2 MAOA MAOB
9
Show member pathways
11.3 MAOA MAOB
10
Show member pathways
11.27 MAOA SLC6A3 SLC6A4
11
Show member pathways
11.26 COMT SLC6A4
12
Show member pathways
11.12 ALDH2 MAOA MAOB
13 11.07 MAOB SLC6A3
14 11 MAOA SLC6A4
15
Show member pathways
10.88 COMT MAOA
16 10.58 COMT MAOA MAOB
17
Show member pathways
10.45 ALDH2 MAOA MAOB
18
Show member pathways
10.45 ALDH2 COMT MAOA SLC6A3 SLC6A4
19
Show member pathways
10.4 ALDH2 COMT MAOA MAOB

GO Terms for Antisocial Personality Disorder

Cellular components related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.92 COMT DRD2 SLC6A3 SNAP25

Biological processes related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.67 DRD2 MAOB SLC6A3
2 response to toxic substance GO:0009636 9.63 DRD2 MAOB SLC6A4
3 neurotransmitter transport GO:0006836 9.59 SLC6A3 SLC6A4
4 response to nicotine GO:0035094 9.58 DRD2 SLC6A3
5 response to cocaine GO:0042220 9.58 DRD2 SLC6A3
6 locomotory behavior GO:0007626 9.58 DRD2 SLC6A3 SNAP25
7 positive regulation of multicellular organism growth GO:0040018 9.57 DRD2 SLC6A3
8 associative learning GO:0008306 9.56 DRD2 SNAP25
9 response to iron ion GO:0010039 9.55 DRD2 SLC6A3
10 response to drug GO:0042493 9.55 COMT DRD2 MAOB SLC6A3 SLC6A4
11 neurotransmitter biosynthetic process GO:0042136 9.54 SLC6A3 SLC6A4
12 dopamine metabolic process GO:0042417 9.52 COMT DRD2
13 ammonium transmembrane transport GO:0072488 9.51 SLC6A3 SLC6A4
14 prepulse inhibition GO:0060134 9.48 DRD2 SLC6A3
15 catecholamine metabolic process GO:0006584 9.43 COMT MAOA
16 adenohypophysis development GO:0021984 9.37 DRD2 SLC6A3
17 monoamine transport GO:0015844 9.32 SLC6A3 SLC6A4
18 dopamine uptake involved in synaptic transmission GO:0051583 9.26 SLC6A3 SLC6A4
19 neurotransmitter catabolic process GO:0042135 9.13 COMT MAOA MAOB
20 dopamine catabolic process GO:0042420 8.92 COMT MAOA MAOB SLC6A3

Molecular functions related to Antisocial Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 syntaxin-1 binding GO:0017075 9.37 SLC6A4 SNAP25
2 neurotransmitter:sodium symporter activity GO:0005328 9.32 SLC6A3 SLC6A4
3 dopamine binding GO:0035240 9.26 DRD2 SLC6A3
4 monoamine transmembrane transporter activity GO:0008504 9.16 SLC6A3 SLC6A4
5 primary amine oxidase activity GO:0008131 8.96 MAOA MAOB
6 dopamine:sodium symporter activity GO:0005330 8.62 SLC6A3 SLC6A4

Sources for Antisocial Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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