ASP
MCID: ANT011
MIFTS: 57

Antisocial Personality Disorder (ASP) malady

Neuronal diseases category

Summaries for Antisocial Personality Disorder

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood.

MalaCards: Antisocial Personality Disorder, also known as psychopathic personality disorder, is related to personality disorder and substance abuse. An important gene associated with Antisocial Personality Disorder is MAOA (monoamine oxidase A), and among its related pathways are Enzymatic degradation of dopamine by COMT and melatonin degradation II. The compounds p-chloroamphetamine and minaprine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related mouse phenotypes are muscle and endocrine/exocrine gland.

Wikipedia:63 Antisocial (or dissocial) personality disorder is characterized by a pervasive pattern of disregard for,... more...

Aliases & Classifications for Antisocial Personality Disorder

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

antisocial personality disorder 8 42 10 44 60
psychopathic personality disorder 8
dissocial personality disorder 8
psychopathic personality 8
sociopathic personality 8
psychopath.personality 8
asocial personality 8
asp 42


External Ids:

Disease Ontology8 DOID:10939
MeSH34 D000987
ICD9CM27 301.7
ICD1025 F60.2

Related Diseases for Antisocial Personality Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Antisocial Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder32.1HTR1B, TTF2, MAOB, MAOA, DRD2, SLC6A3
2substance abuse31.2DRD2, ALDH2, SLC6A4, SLC6A3
3conduct disorder31.1TTF2, MAOA, DRD2, COMT, SLC6A3, SLC6A4
4schizophrenia31.1COMT, HTR2A
5borderline personality disorder31.0MAOA, HTR1B, SLC6A4, TTF2
6alcohol dependence30.9HTR1B, ALDH2, HTR2A, MAOA, ANKK1, GABRA6
7cocaine dependence30.9SLC6A3, DRD2, SLC6A4
8substance dependence30.9COMT, DRD2, SLC6A3, SLC6A4
9anxiety disorder30.9SLC6A4, MAOA
10heroin dependence30.7DRD2, ANKK1
11alcohol abuse30.7ALDH2, SLC6A4, SLC6A3, COMT, DRD2
12pathological gambling30.6DRD2, SLC6A3
13bipolar disorder30.4HTR2A, SLC6A4, MAOA
14drug dependence30.4MAOA, SLC6A3, DRD2, SLC6A4
15attention deficit hyperactivity disorder30.4COMT, HTR1B, HTR2A, DRD2, SNAP25, SLC6A4
16alexithymia30.2ANKK1
17cocaine abuse30.2SLC6A4, SLC6A3, DRD2
18bulimia nervosa30.2COMT, SLC6A4, MAOA, HTR2A, HTR1B
19dementia30.2MAOA, MAOB, TTF2, ALDH2, SLC6A3, HTR2A
20obesity30.1HTR2A, DRD2, MAOA, MAOB, TTF2, SLC6A3
21hepatitis30.0TTF2, COMT
22hypertension29.8SLC6A4
23diabetes mellitus29.8ALDH2
24dependent personality disorder10.9
25sexual disorder10.5
26thalassemia10.5
27sleep disorder10.4
28alpha thalassemia10.4
29aspergillosis10.4
30beta thalassemia10.3
31alveolar soft part sarcoma10.3
32somatization disorder10.3
33sexual sadism10.3
34impulse control disorder10.3
35allergic bronchopulmonary aspergillosis10.3
36coronary artery disease10.2
37sarcoma10.2
38dissociative disorder10.2
39lung cancer10.2
40major depressive disorder10.2
41narcissistic personality disorder10.2
42histrionic personality disorder10.2
43physical disorder10.2
44leukemia10.2
45canavan disease10.1
46hypophosphatasia10.1
47hemolytic anemia10.1
48intellectual disability10.1
49stroke, ischemic10.0
50melanoma10.0

Graphical network of the top 20 diseases related to Antisocial Personality Disorder:



Diseases related to antisocial personality disorder

Clinical Features for Antisocial Personality Disorder

About this section

Drugs & Therapeutics for Antisocial Personality Disorder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Antisocial Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Antisocial Personality Disorder

Search NIH Clinical Center for Antisocial Personality Disorder

Search CenterWatch for Antisocial Personality Disorder

Genetic Tests for Antisocial Personality Disorder

About this section

Anatomical Context for Antisocial Personality Disorder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Antisocial Personality Disorder:

32
Brain, Eye, Cortex, Testes, Prefrontal cortex

Animal Models for Antisocial Personality Disorder or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Antisocial Personality Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4SLC6A4, SLC6A3, SNAP25, DRD2, HTR2A, HTR1B
2MP:00053797.9HTR1B, HTR2A, DRD2, SNAP25, PRL, SLC6A3
3MP:00053907.7HTR1B, HTR2A, DRD2, GABRB2, SNAP25, SLC6A3
4MP:00053897.4COMT, HTR1B, DRD2, SNAP25, PRL, SLC6A3
5MP:00036316.4COMT, DRD2, GABRB2, GABRA6, SNAP25, PRL
6MP:00053766.3GABRA6, GABRB2, DRD2, COMT, SNAP25, PRL
7MP:00053865.9ALDH2, COMT, HTR1B, HTR2A, DRD2, GABRB2

Publications for Antisocial Personality Disorder

About this section
Sources:
50PubMed
See all sources

Articles related to Antisocial Personality Disorder:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Gender differences in prevalence and correlates of antisocial personality disorder among heroin dependent users in compulsory isolation treatment in China. (24342175)
2014
2
The social-cognitive basis of borderline and antisocial personality disorder: introduction. (23342953)
2013
3
The Association Between ADHD and Antisocial Personality Disorder (ASPD): A Review. (24284138)
2013
4
Adult antisocial syndrome co-morbid with borderline personality disorder is associated with severe conduct disorder, substance dependence and violent antisociality. (24343921)
2013
5
Effects of emotional stimuli on working memory processes in male criminal offenders with borderline and antisocial personality disorder. (22381099)
2013
6
Admitting offenders with antisocial personality disorder to a medium secure unit: a qualitative examination of multidisciplinary team decision-making. (24009472)
2013
7
Borderline but not antisocial personality disorder symptoms are related to self-reported partner aggression in late middle-age. (22732005)
2012
8
Electroencephalographic abnormalities in antisocial personality disorder. (22152445)
2012
9
Crack users show high rates of antisocial personality disorder, engagement in illegal activities and other psychosocial problems. (22691017)
2012
10
Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not co-morbid with alcoholism. (21070510)
2012
11
Differences in treatment outcome among marijuana-dependent young adults with and without antisocial personality disorder. (22242558)
2012
12
Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopathy. (21756448)
2011
13
Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. (20363030)
2010
14
Antisocial personality disorder--stable and unstable subtypes. (20420474)
2010
15
Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. (17592478)
2008
16
Externalizing pathology and the five-factor model: a meta-analysis of personality traits associated with antisocial personality disorder, substance use disorder, and their co-occurrence. (18684050)
2008
17
Treatment of antisocial personality disorder. (18978330)
2008
18
The different origins of stability and change in antisocial personality disorder symptoms. (17049101)
2007
19
Psychotherapists' countertransference reactions toward clients with antisocial personality disorder and schizophrenia: an empirical test of theory. (18251383)
2007
20
The neuropsychology of antisocial personality disorder. (17544650)
2007
21
Personality trait differences in boys and girls with clinical or sub-clinical diagnoses of conduct disorder versus antisocial personality disorder. (17067666)
2007
22
Effects of comorbid psychopathy on criminal offending and emotion processing in male offenders with antisocial personality disorder. (17100537)
2006
23
Antisocial personality disorder as a confounder in PTSD and substance use disorders. (17012703)
2006
24
Etiology of antisocial personality disorder: benefits for society from an evolutionary standpoint. (16006050)
2005
25
Executive-cognitive functioning in the development of antisocial personality disorder. (12573679)
2003
26
Chronological relationship between antisocial personality disorder and alcohol dependence. (12457061)
2002
27
The neuropsychology of antisocial personality disorder. (11989987)
2002
28
What are adolescent antecedents to antisocial personality disorder? (12357255)
2002
29
Alexithymia in patients with antisocial personality disorder in a military hospital setting. (11475919)
2001
30
A twin study of the association between pathological gambling and antisocial personality disorder. (11358024)
2001
31
The effect of systematic variation in retrospective conduct disorder reports on antisocial personality disorder diagnoses. (10780131)
2000
32
Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. (10665614)
2000
33
Premorbid risk factors for alcohol dependence in antisocial personality disorder. (10656190)
2000
34
Therapeutic community treatment for substance abusers with antisocial personality disorder. (10435260)
1999
35
Psychopathy and antisocial personality disorder among alcoholic inpatients. (10371260)
1999
36
Antisocial personality disorder, psychopathy and injecting heroin use. (9788008)
1998
37
Antisocial personality disorder and psychopathy: diagnostic dilemmas in classifying patterns of antisocial behavior in sentencing evaluations. (9768465)
1998
38
Temporal stability of diagnostic criteria for antisocial personality disorder in male alcohol dependent patients. (9891286)
1998
39
An ethical framework for understanding patients with antisocial personality disorder who develop dementia: diagnosing and managing disorders of autonomy. (11656997)
1997
40
Predictors of long-term outcome in 45 men with antisocial personality disorder. (9511944)
1997
41
The long-term outcome of antisocial personality disorder compared with depression, schizophrenia, and surgical conditions. (7599370)
1995
42
Antisocial personality disorder, misbehavior, and drug abuse. (7891062)
1995
43
Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. (7978086)
1994
44
Prevalence, symptoms and correlates of antisocial personality disorder among methadone maintenance clients. (8033764)
1994
45
Antisocial personality disorder among drug abusers. Relations to other personality diagnoses and the five-factor model of personality. (8501448)
1993
46
Antisocial personality disorder. (8373756)
1993
47
Treatment outlines for antisocial personality disorder. The Quality Assurance Project. (1793424)
1991
48
The antisocial personality disorder diagnosis in substance abusers: problems and issues. (1869868)
1991
49
Gender comparison of antisocial personality disorder and depression in alcoholism. (1668227)
1991
50
The dysphoric psychopath: a comparison of 524 cases of antisocial personality disorder with matched controls. (6884012)
1983

Genetic Variations for Antisocial Personality Disorder

About this section

Expression for genes affiliated with Antisocial Personality Disorder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Antisocial Personality Disorder

Search GEO for disease gene expression data for Antisocial Personality Disorder.

Pathways for genes affiliated with Antisocial Personality Disorder

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 49PharmGKB
See all sources

Pathways related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7ALDH2, SLC6A3, MAOA
2
Hide members
9.6ALDH2, MAOB, MAOA
3
Hide members
9.6ALDH2, MAOB, MAOA
49.6ALDH2, MAOB, MAOA
59.6MAOA, MAOB, ALDH2
6
Hide members
9.6MAOA, MAOB, ALDH2
7
Hide members
9.5COMT, MAOA, MAOB
8
Hide members
9.5COMT, MAOA, MAOB
9
Tyrosine metabolism p.1 (dopamine)
Hide members
9.5MAOB, MAOA, COMT
109.4DRD2, MAOA, MAOB, SLC6A3
11
Hide members
9.4DRD2, MAOA, MAOB, SLC6A3
12
Hide members
9.2HTR1B, HTR2A, DRD2, MAOA, SLC6A4
13
Hide members
9.2ALDH2, MAOB, MAOA, COMT
148.9HTR2A, SNAP25, MAOA, SLC6A4
15
Hide members
8.4HTR1B, HTR2A, DRD2, GABRB2, GABRA6, PRL
16
Hide members
7.6COMT, GABRB2, GABRA6, SNAP25, MAOA, SLC6A3
17
Hide members
7.3SLC6A4, COMT, HTR1B, HTR2A, DRD2, GABRB2

Compounds for genes affiliated with Antisocial Personality Disorder

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 283)
idCompoundScoreTop Affiliating Genes
1p-chloroamphetamine449.7SLC6A4, SLC6A3, MAOB, MAOA
2minaprine44 1110.7SLC6A4, MAOA, DRD2, HTR2A
3phentermine44 1110.7SLC6A4, SLC6A3, MAOB, MAOA
44-Methoxyamphetamine119.7SLC6A4, SLC6A3, MAOB, MAOA
5d amphetamine449.5DRD2, MAOA, MAOB, SLC6A3, SLC6A4
6mcpp449.5SLC6A4, HTR1B, HTR2A, PRL
7MMDA119.5MAOB, HTR2A, MAOA, SLC6A4, SLC6A3
8Ephedra119.5SLC6A4, SLC6A3, MAOA, MAOB
9venlafaxine49 44 11 2412.5SLC6A4, SLC6A3, HTR2A, HTR1B, GABRA6
10pindolol44 28 1111.4SLC6A4, HTR1B, PRL, HTR2A
11clomipramine44 49 1111.4MAOA, HTR2A, SLC6A3, SLC6A4, PRL
12amoxapine44 28 1111.4SLC6A4, PRL, DRD2, HTR2A
13trimipramine49 44 1111.4SLC6A4, HTR2A, DRD2, PRL, SLC6A3
14mdma449.3PRL, MAOA, MAOB, SLC6A3, SLC6A4
15amitriptyline44 49 28 1112.3MAOA, SLC6A4, MAOB, SLC6A3, HTR2A
16tyramine44 28 2411.3COMT, SLC6A4, SLC6A3, MAOB, MAOA
17terguride28 4410.3PRL, HTR1B, HTR2A, DRD2
18ropinirole44 1110.3HTR1B, HTR2A, MAOB, DRD2, COMT
19sertindole28 44 1111.2PRL, DRD2, HTR2A, HTR1B
20quetiapine44 49 28 11 2413.2HTR2A, SLC6A3, HTR1B, DRD2, PRL
21pergolide28 44 1111.2HTR1B, HTR2A, DRD2, PRL, COMT
22carbidopa44 2810.2SLC6A3, MAOB, COMT, PRL
23cabergoline28 44 1111.2HTR1B, PRL, COMT, DRD2, HTR2A
24mhpg449.2MAOA, MAOB, SLC6A4, COMT, PRL
25methylphenidate44 49 1111.2COMT, DRD2, MAOA, MAOB, SLC6A3, SLC6A4
26amphetamine44 1110.1SLC6A4, SLC6A3, DRD2, MAOA, MAOB
27homovanillic acid44 2410.1MAOA, COMT, PRL, MAOB, SLC6A4
28methamphetamine44 49 1111.1SLC6A4, MAOB, MAOA, DRD2, COMT, SLC6A3
29mptp449.1SLC6A3, SLC6A4, COMT, MAOA, DRD2, MAOB
30citalopram49 44 11 2412.0SLC6A4, SLC6A3, HTR2A, PRL, MAOA, MAOB
31bupropion44 49 11 2412.0COMT, DRD2, ANKK1, MAOB, SLC6A3, SLC6A4
32pramipexole44 49 28 1112.0COMT, HTR2A, HTR1B, PRL, SLC6A3, DRD2
33bromocriptine28 44 1111.0HTR1B, SLC6A3, PRL, DRD2, HTR2A, COMT
34ritanserin28 449.9PRL, HTR1B, DRD2, HTR2A
35haloperidol44 28 2 49 1112.9DRD2, PRL, MAOB, SLC6A3, SLC6A4, HTR2A
366-hydroxydopamine448.9DRD2, COMT, SLC6A3, MAOB, MAOA
37paroxetine44 49 28 1111.8HTR2A, COMT, HTR1B, PRL, SLC6A4, SLC6A3
38olanzapine49 44 28 11 2412.7HTR1B, SLC6A3, HTR2A, DRD2, PRL, ANKK1
39levodopa44 119.7COMT, HTR1B, MAOB, DRD2, SLC6A3, MAOA
40maoa448.7HTR1B, MAOB, HTR2A, DRD2, MAOA, SLC6A3
41apomorphine44 28 1110.7MAOB, PRL, COMT, DRD2, HTR1B, HTR2A
42cocaine44 119.6SLC6A4, SLC6A3, MAOB, DRD2, PRL, HTR1B
43fluoxetine49 44 28 1111.6SLC6A4, SLC6A3, MAOB, MAOA, PRL, DRD2
44nicotine44 49 28 1111.6SLC6A3, TTF2, DRD2, ANKK1, COMT, MAOA
45risperidone28 44 49 59 11 2413.5COMT, SLC6A4, SLC6A3, ANKK1, PRL, DRD2
46clozapine44 28 49 1111.5DRD2, PRL, ANKK1, SLC6A3, SLC6A4, HTR2A
47gaba448.2GABRA6, SNAP25, MAOA, MAOB, SLC6A3, SLC6A4
485-hydroxytryptamine448.2PRL, MAOA, MAOB, SLC6A4, DRD2, HTR2A
49norepinephrine44 11 249.6COMT, SLC6A3, HTR2A, SLC6A4, DRD2, SNAP25
50dopamine44 28 11 2410.1SLC6A3, SLC6A4, MAOB, MAOA, PRL, ALDH2

GO Terms for genes affiliated with Antisocial Personality Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058877.5SLC6A4, COL25A1, HTR1B, HTR2A, DRD2, GABRB2
2plasma membraneGO:0058866.6COMT, HTR1B, HTR2A, DRD2, GABRB2, GABRA6

Biological processes related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1monoamine transportGO:01584410.2SLC6A3, SLC6A4
2adenohypophysis developmentGO:02198410.2SLC6A3, DRD2
3G-protein coupled receptor internalizationGO:00203110.1DRD2, HTR1B
4negative regulation of serotonin secretionGO:01406310.1MAOB, HTR1B
5response to iron ionGO:01003910.1SLC6A3, DRD2
6neurotransmitter catabolic processGO:04213510.1MAOA, COMT
7regulation of behaviorGO:05079510.0HTR2A, HTR1B
8response to cocaineGO:04222010.0HTR1B, DRD2, SLC6A3
9negative regulation of synaptic transmission, glutamatergicGO:05196710.0DRD2, HTR2A, HTR1B
10regulation of dopamine secretionGO:01405910.0HTR1B, HTR2A, DRD2
11vasoconstrictionGO:04231010.0SLC6A4, HTR1B
12prepulse inhibitionGO:06013410.0DRD2, SLC6A3
13dopamine catabolic processGO:0424209.9SLC6A3, MAOA, COMT
14response to toxic substanceGO:0096369.8DRD2, MAOB, SLC6A4
15temperature homeostasisGO:0016599.6DRD2, HTR2A
16neurotransmitter biosynthetic processGO:0421369.6COMT, MAOA, SLC6A3, ALDH2
17response to ethanolGO:0454719.5SLC6A3, MAOB, PRL, HTR1B
18xenobiotic metabolic processGO:0068059.4ALDH2, MAOB, MAOA, COMT
19response to lipopolysaccharideGO:0324969.1MAOB, PRL, COMT
20response to drugGO:0424938.5COMT, HTR2A, DRD2, PRL, MAOB, SLC6A3
21synaptic transmissionGO:0072687.4ALDH2, COMT, HTR1B, HTR2A, GABRB2, GABRA6

Molecular functions related to Antisocial Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.0SLC6A4, SLC6A3
2primary amine oxidase activityGO:0081319.9MAOA, MAOB
3serotonin bindingGO:0513789.9HTR2A, HTR1B
4dopamine bindingGO:0352409.7SLC6A3, DRD2
5GABA-A receptor activityGO:0048909.6GABRA6, GABRB2
6drug bindingGO:0081449.6SLC6A3, DRD2, HTR2A, HTR1B

Products for genes affiliated with Antisocial Personality Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Antisocial Personality Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet