Antley-bixler Syndrome malady

Disease Ontology: An autosomal recessive disease that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the fgfr2 gene.⁶

MalaCards: Antley-bixler Syndrome, also known as antley bixler syndrome, is related to disordered steroidogenesis and radioulnar synostosis. An important gene associated with Antley-bixler Syndrome is POR (P450 (cytochrome) oxidoreductase), and among its related pathways are Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics and Estrogen Metabolism Pathway. The compounds aminopyrine and 7-ethoxycoumarin have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

OMIM: 207410

Aliases & Descriptions:

antley-bixler syndrome 6 33 8 32 43 antley bixler syndrome 30 16 multisynostotic osteodysgenesis with long bone fractures 30 osteodysgenesis, multisynostotic with fractures 30

trapezoidocephaly- mulitple synostosis syndrome 16 trapezoidocephaly-synostosis syndrome 6 trapezoidocephaly synostosis syndrome 30 abs 30

Diseases related to antley-bixler syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 244)

id	Related Disease	Score	Top Affiliating Genes
1	disordered steroidogenesis	32.2	FGFR2, CYCS, CYP17A1, POR
2	radioulnar synostosis	31.5	FGFR1, FGFR2, FGFRL1
3	adrenal hyperplasia	31.4	CYP17A1, CYP19A1, CYP21A2, POR, POMC
4	synostosis	30.9	FGFR1, FGFR2, FGFRL1, CYP51A1, POR
5	virilization	30.1	CYP17A1, CYP19A1, CYP21A2, POR, POMC
6	cockayne syndrome	29.2	FGFR1, FGFR2
7	breast cancer	28.1	FGFR2, CYP1A2, CYP1B1, CYP3A4, CYP2C19, CYP17A1
8	pancreatic cancer	26.3	FGFR1, FGFR2, CYP1A2, CYP1B1, CYP2A6, CYCS
9	hodgkin's lymphoma	25.7	FGFR1, CYP1A2, CYP1B1, CYP3A4, CYP2C19, CYCS
10	colon carcinoma	25.4	FGFR1, FGFR2, CYP1A2, CYP1B1, CYP3A4, CYCS
11	polycystic ovary syndrome	25.4	CYP17A1, CYP19A1, CYP21A2, POR, POMC
12	arthritis	25.4	FGFR1, FGFR2, CYP1A2, CYP3A4, CYP2C19, CYCS
13	pancreatitis	24.9	FGFR1, FGFR2, CYP1A2, CYP1B1, CYP2A6, CYCS
14	parkinson's disease	24.2	CYP1A2, CYP3A4, CYP2B6, CYP2C19, CYCS
15	neuronitis	24.2	FGFR1, FGFR2, CYB5A, CYP1A2, CYP1B1, CYP2A6
16	colon cancer	24.1	FGFR1, FGFR2, CYP1A2, CYP1B1, CYP3A4, CYP2A6
17	hypoxia	24.1	CYB5A, CYP1A2, CYP1B1, CYP2B6, CYP2C19, CYCS
18	glioblastoma	24.0	FGFR1, FGFR2, CYP1A2, CYP1B1, CYP3A4, CYCS
19	obesity	24.0	FGFR1, CYB5A, CYP1A2, CYP3A4, CYP2A6, CYP2C19
20	colorectal cancer	23.9	FGFR1, FGFR2, CYP51A1, CYP1A2, CYP1B1, CYP3A4
21	hypercholesterolemia	23.7	CYP1B1, CYP3A4, CYP3A43, CYP2A6, CYP2B6, CYP2C19
22	rheumatoid arthritis	23.6	FGFR1, FGFR2, CYP1A2, CYP3A4, CYP2C19, CYCS
23	malaria	22.9	CYB5A, CYP1B1, CYP3A4, CYP3A43, CYP2A6, CYP2B6
24	ovarian cancer	22.8	FGFR1, FGFR2, CYP1A2, CYP1B1, CYP3A4, CYP2A6
25	carcinoma	22.6	FGFR1, FGFR2, CYB5A, CYP1A2, CYP1B1, CYP3A4
26	asthma	22.4	FGFR1, CYP1A2, CYP1B1, CYP3A4, CYP2C19, CYCS
27	leukemia	22.3	FGFR1, FGFR2, CYP51A1, CYP1A2, CYP1B1, CYP3A4
28	gastric cancer	22.0	FGFR1, FGFR2, CYP1A2, CYP1B1, CYP3A4, CYP2A6
29	prostatitis	21.8	FGFR1, FGFR2, CYP51A1, CYP1A2, CYP1B1, CYP3A4
30	breast carcinoma	21.8	FGFR1, FGFR2, CYP1A2, CYP1B1, CYP3A4, CYP2C19
31	tuberculosis	21.5	CYP51A1, CYP1A2, CYP3A4, CYP3A43, CYP2A6, CYP2B6
32	hepatocellular carcinoma	19.5	FGFR1, FGFR2, CYB5A, CYP1A2, CYP1B1, CYP3A4
33	hepatitis	19.4	CYB5A, CYP1A2, CYP1B1, CYP3A4, CYP2A6, CYP2B6
34	jackson-weiss syndrome	13.5	FGFR1, FGFR2
35	fgfr-related craniosynostosis syndromes	13.5	FGFR1, FGFR2
36	osteoglophonic dysplasia	13.5	FGFR1, FGFR2
37	muenke syndrome	13.5	FGFR1, FGFR2
38	precocious puberty, male	13.5	CYP19A1, CYP21A2
39	3-beta-hydroxysteroid dehydrogenase deficiency	13.5	CYP17A1, CYP21A2
40	testicular leydig cell tumor	13.5	CYP19A1, CYP21A2
41	plagiocephaly	13.4	FGFR1, FGFR2
42	transsexualism	13.4	CYP17A1, CYP19A1, CYP21A2
43	delayed puberty	13.3	FGFR1, CYP17A1, CYP19A1
44	autoimmune polyendocrine syndrome type 1	13.3	CYP1A2, CYP17A1, CYP21A2
45	chst3-related skeletal dysplasia	13.3	FGFR1, FGFR2, CYP17A1, POR
46	uterine fibroid	13.3	CYP17A1, CYP19A1, CYP21A2
47	mycetoma	13.2	CYP1B1, CYP17A1, CYP19A1
48	craniosynostosis	13.2	FGFR1, FGFR2, FGFRL1, POR
49	crouzon syndrome	13.1	FGFR1, FGFR2
50	acrocephalosyndactylia	13.0	FGFR1, FGFR2

Clinical features from OMIM: 207410

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to antley-bixler syndrome:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	7.5	FGFR1, POMC, POR, NSDHL, CYP19A1, CYCS
2	homeostasis/metabolism phenotype	MP:0005376	7.4	CYP17A1, CYP19A1, NSDHL, POR, CYP1B1, CYP1A2
3	behavior/neurological phenotype	MP:0005386	7.3	POMC, POR, NSDHL, CYP19A1, CYP17A1, CYCS

Articles related to antley-bixler syndrome:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Cytochrome P450 oxidoreductase deficiency with Antley -Bixler syndrome: steroidogenic capacities. (19618668)	Iijima S.... Ohzeki T.	2009	POMC, CYP17A1, CYP21A2
2	A case of Antley-Bixler syndrome caused by compound heterozygous mutations of the cytochrome P450 oxidoreductase gene. (18853185)	Ko J.M.... Yoo H.W.	2009	POR, CYP21A2
3	Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase. (18455494)	Kranendonk M.... Rueff J.	2008	POR, CYP1A2
4	Antley-Bixler syndrome or POR deficiency? (18630181)	Tomkova M.... Martasek P.	2008	POR
5	P450 oxidoreductase deficiency and Antley-Bixler syndrome. (17960482)	Arlt W.	2007	POR
6	Diminished FAD binding in the Y459H and V492E Antley-Bixler syndrome mutants of human cytochrome P450 reductase. (16998238)	Marohnic C.C.... Masters B.S.	2006	POR
7	Linking Antley-Bixler syndrome and congenital adrenal hyperplasia: a novel case of P450 oxidoreductase deficiency. (16906539)	Williamson L.... Braddock S.R.	2006	POR
8	Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. (15793702)	Huang N.... Miller W.L.	2005	FGFR2, POR, CYP17A1
9	Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients. (15483095)	Fukami M.... Ogata T.	2005	POR, CYP19A1, CYP17A1
10	Undetectable maternal serum uE3 and postnatal abnormal sterol and steroid metabolism in Antley-Bixler syndrome. (15266606)	Cragun D.L.... Hopkin R.J.	2004	POR, CYP51A1, CYB5A
11	Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. (14758361)	Flueck C.E.... Miller W.L.	2004	POR
12	Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome. (15264278)	Adachi M.... Oka A.	2004	POR, CYP51A1
13	Abnormal steroidogenesis in three patients with Antley-Bixler syndrome: apparent decreased activity of 17alpha-hydroxylase, 17,20-lyase and 21-hydroxylase. (15491389)	Adachi M.... Shackleton C.	2004	CYP21A2, CYP51A1
14	Antley-Bixler syndrome with radioulnar synostosis. (14513299)	Hurley M.E.... Kelleher J.	2004	FGFR1
15	Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype. (15316970)	Shackleton C.... Hauffa B.P.	2004	POR, CYP19A1
16	Biochemical diagnosis of Antley-Bixler syndrome by steroid analysis. (15216541)	Shackleton C.... Arlt W.	2004	FGFR2, CYP21A2
17	Further evidence that fibroblast growth factor receptor 2 mutations cause Antley-Bixler syndrome. (11430730)	Tsai F.J.... Tsai C.H.	2001	FGFR2
18	Evidence for digenic inheritance in some cases of Antley-Bixler syndrome? (10633130)	Reardon W.... Winter R.M.	2000	FGFR2
19	Features of Antley-Bixler syndrome in an infant born to a mother with pregnancy luteoma. (10664233)	Roth C.... Lakomek M.	2000	CYP21A2
20	Congenital adrenal hyperplasia associated with maternal pregnancy luteoma and the Antley-Bixler syndrome. (10726707)	Warmann S.... Fuchs J.	2000	CYP21A2
21	FGFR2 mutation associated with clinical manifestations consistent with Antley-Bixler syndrome. (9605588)	Chun K.... Ray P.N.	1998	FGFR2

Genes related to antley-bixler syndrome according to GeneCards:

(show all 23)

id	Symbol	Description	Score	GeneCards Section Context
1	POR	P450 (cytochrome) oxidoreductase	11.1	Summaries, Publications
2	FGFR1	fibroblast growth factor receptor 1	11.1	Publications, Summaries
3	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.1	Publications
4	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.1	Publications
5	FGFR2	fibroblast growth factor receptor 2	11.1	Publications
6	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.1	Publications
7	CYP2D7P1	cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1	11.0
8	CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1	11.0	Publications
9	FGFRL1	fibroblast growth factor receptor-like 1	11.0
10	NSDHL	NAD(P) dependent steroid dehydrogenase-like	11.0
11	CYP4X1	cytochrome P450, family 4, subfamily X, polypeptide 1	11.0	Disorders
12	CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	11.0
13	CYB5A	cytochrome b5 type A (microsomal)	11.0	Publications
14	CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	11.0
15	CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	11.0
16	CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	11.0	Publications
17	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	11.0
18	CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	11.0
19	CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	11.0
20	CYCS	cytochrome c, somatic	11.0	Publications
21	POMC	proopiomelanocortin	11.0	Publications
22	CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	11.0
23	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0

Pathways related to antley-bixler syndrome according to GeneDecks:

(show top 50)    (show all 57)

id	Pathway	Score	Top Affiliating Genes
1	Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics34	10.4	POR
2	Estrogen Metabolism Pathway34	9.8	CYP19A1, CYP1B1, CYP1A2
3	Erlotinib Pathway, Pharmacokinetics34	9.6	CYP3A5, CYP3A4, CYP1A2
4	Theophylline Pathway, Pharmacokinetics34	9.6	CYP1A2, CYP3A4
5	Nevirapine Pathway, Pharmacokinetics34	9.5	CYP3A5, CYP2B6, CYP3A4
6	Caffeine Pathway, Pharmacokinetics34	9.5	CYP2A6, CYP3A4, CYP1A2
7	Taxane Pathway, Pharmacokinetics34	9.5	CYP3A5, CYP3A4, CYP1B1
8	Benzo[a]pyrene metabolism41	9.5	CYP3A4, CYP1B1, CYP1A2
9	Benzo[a]pyrene metabolism10	9.5	CYP3A4, CYP1B1, CYP1A2
10	Acetaminophen metabolism41	9.4	CYP2A6, CYP3A4, CYP1A2
11	Acetaminophen metabolism10	9.4	CYP2A6, CYP3A4, CYP1A2
12	Drug metabolism - other enzymes20	9.3	CYP3A5, CYP2A6, CYP3A43, CYP3A4
13	Estrogen biosynthesis10	9.3	CYP3A4, CYP2C19, CYP19A1
14	Estrogen biosynthesis41	9.2	CYP3A4, CYP2C19, CYP19A1
15	2-Naphthylamine and 2-Nitronaphtalene metabolism41	9.2	CYP2B6, CYP3A4, CYP1A2
16	Naphthalene metabolism41	9.2	CYP2A6, CYP3A4, CYP1A2
17	Fluoxetine Pathway, Pharmacokinetics34	9.2	CYP3A5, CYP2C19, CYP3A4
18	Ifosfamide Pathway, Pharmacokinetics34	9.2	CYP3A5, CYP2B6, CYP2A6, CYP3A4
19	Artemisinin and Derivatives Pathway, Pharmacokinetics34	9.2	CYP3A5, CYP2B6, CYP2A6, CYP3A4
20	Imipramine/Desipramine Pathway, Pharmacokinetics34	9.2	CYP2C19, CYP3A4, CYP1A2
21	Clomipramine Pathway, Pharmacokinetics34	9.2	CYP2C19, CYP3A4, CYP1A2
22	Gefitinib Pathway, Pharmacokinetics34	9.2	CYP3A5, CYP2C19, CYP3A4
23	Warfarin Pathway, Pharmacokinetics34	9.1	CYP2C19, CYP3A4, CYP1A2
24	Naphthalene metabolism10	9.1	CYP2A6, CYP3A4, CYP1A2
25	Fluvastatin Pathway, Pharmacokinetics34	9.1	CYP3A5, CYP2C19, CYP3A4
26	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics34	9.0	CYP3A5, CYP2C19, CYP3A4
27	Androstenedione and testosterone biosynthesis and metabolism p.141	9.0	CYP3A4, CYP2C19, CYP17A1, CYP3A5
28	Statin Pathway - Generalized, Pharmacokinetics34	9.0	CYP3A4, CYP2C19, CYP3A5
29	Steroid hormone biosynthesis20	8.9	CYP3A5, CYP21A2, CYP19A1, CYP17A1, CYP3A43, CYP3A4
30	Benzodiazepine Pathway, Pharmacokinetics34	8.9	CYP3A5, CYP2C19, CYP3A4, CYP1A2
31	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics34	8.9	CYP3A5, CYP2C19, CYP3A4, CYP1A2
32	Estrone metabolism41	8.8	CYP3A5, CYP2C19, CYP3A4, CYP1A2
33	Estrone metabolism10	8.8	CYP3A5, CYP2C19, CYP3A4, CYP1A2
34	Proton Pump Inhibitor Pathway, Pharmacokinetics34	8.8	CYP3A4, CYP2C19
35	Androstenedione and testosterone biosynthesis and metabolism p.110	8.7	CYP3A4, CYP2C19, CYP17A1, CYP3A5, CYP1A2
36	Estradiol metabolism41	8.5	CYP3A5, CYP2C19, CYP1A2, CYP1B1, CYP3A4
37	Estradiol metabolism10	8.5	CYP1A2, CYP1B1, CYP3A4, CYP2C19, CYP3A5
38	Clopidogrel Pathway, Pharmacokinetics34	8.4	CYP3A5, CYP2C19, CYP2B6, CYP3A4, CYP1A2
39	Tamoxifen Pathway, Pharmacokinetics34	8.4	CYP3A5, CYP2C19, CYP2B6, CYP3A4, CYP1A2
40	Cyclophosphamide Pathway, Pharmacokinetics34	8.4	CYP3A5, CYP2C19, CYP2B6, CYP2A6, CYP3A4
41	Linoleic acid metabolism20	8.3	CYP2J2, CYP3A5, CYP2C19, CYP3A43, CYP3A4, CYP1A2
42	Carbamazepine Pathway, Pharmacokinetics34	8.0	CYP3A5, CYP2C19, CYP2B6, CYP2A6, CYP3A4, CYP1A2
43	Phenytoin Pathway, Pharmacokinetics34	8.0	CYP3A5, CYP2C19, CYP2B6, CYP2A6, CYP3A4, CYP1A2
44	Metabolism of xenobiotics by cytochrome P45020	7.8	CYP3A5, CYP2C19, CYP2B6, CYP3A43, CYP3A4, CYP1B1
45	Retinol metabolism20	7.8	CYP3A5, CYP2C19, CYP2B6, CYP2A6, CYP3A43, CYP3A4
46	Drug metabolism - cytochrome P45020	7.8	CYP3A5, CYP2C19, CYP2B6, CYP2A6, CYP3A43, CYP3A4
47	Retinol metabolism10	7.7	CYP3A5, CYP2C19, CYP2B6, CYP2A6, CYP3A4, CYP1B1
48	Retinol metabolism41	7.7	CYP3A5, CYP2C19, CYP2B6, CYP2A6, CYP3A4, CYP1B1
49	Biological oxidations38	7.5	CYP1B1, CYP2J2, CYP3A5, CYP2C19, CYP2B6, CYP2A6
50	Metabolic pathways20	6.4	NSDHL, CYP2J2, CYP3A5, CYP21A2, CYP19A1, CYP17A1

Compounds related to antley-bixler syndrome according to GeneDecks:

(show top 50)    (show all 449)

id	Compound	Score	Top Affiliating Genes
1	aminopyrine32	8.7	CYB5A, POR, CYP1A2, CYP2A6, CYP2B6, CYP17A1
2	7-ethoxycoumarin32	8.6	POR, CYB5A, CYP1A2, CYP2B6, CYP1B1, CYP2A6
3	benzphetamine32 9 9	10.2	CYP2B6, CYB5A, CYP1A2, CYP3A4, CYP2A6, POR
4	metyrapone32 42 9 9	11.1	CYP1A2, CYP2B6, CYP21A2, POMC, POR, CYP3A4
5	aflatoxin b132 18	9.0	CYB5A, CYP1A2, CYP1B1, CYP3A4, CYP2A6, CYP2B6
6	lauric acid32	8.0	CYB5A, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2C19
7	pentoxyresorufin32	7.9	CYB5A, CYP1A2, CYP3A4, CYP2A6, CYP2B6, CYP2C19
8	alpha-naphthoflavone32	7.8	CYP2A6, CYP2B6, CYP2C19, POR, CYP3A4, CYP1B1
9	bufuralol32 9 9	9.8	POR, CYP2C19, CYP1A2, CYP1B1, CYP3A4, CYP2A6
10	miconazole32 9 9	9.7	CYP51A1, CYP3A4, CYP2A6, CYP2B6, CYP2C19, CYP19A1
11	androstane32	7.6	CYP1A2, POR, CYP3A5, CYP17A1, CYP2C19, CYP2B6
12	troleandomycin32 9 9	9.6	POR, CYP3A5, CYP2C19, CYP2B6, CYP1A2, CYP3A4
13	rifampin34 9 9	9.6	CYP3A43, CYP1A2, CYP3A4, CYP2A6, CYP2B6, CYP2C19
14	beta-naphthoflavone32 9 9	9.5	CYB5A, CYP1A2, CYP1B1, CYP3A4, CYP2A6, CYP2B6
15	clotrimazole32 9 18 9	10.5	CYP51A1, CYP1A2, CYP2B6, CYP2A6, CYP3A4, CYP2C19
16	aminoglutethimide32 9 9	9.5	CYP21A2, POMC, CYP2C19, CYP3A4, CYP1A2, CYP19A1
17	ethoxyresorufin32	7.5	CYP1A2, CYP1B1, CYP3A4, CYP2A6, CYP2B6, CYP2C19
18	methadone32 34 9 9	10.4	CYP3A5, CYP19A1, CYP2C19, CYP2B6, CYP3A4, CYP1A2
19	coumarin32 18	8.4	CYP3A5, CYP2C19, CYB5A, CYP1A2, CYP1B1, CYP3A4
20	tolbutamide32 34 9 9	10.3	CYP2C19, CYP3A4, CYP3A5, CYB5A, CYP1A2, CYP2A6
21	erythromycin32 9 9	9.3	CYP2A6, CYP2B6, CYP2C19, CYP3A5, POR, CYP3A4
22	epoxide32	7.2	CYP2C19, CYP2J2, POR, CYP2B6, CYP2A6, CYP3A4
23	chlorzoxazone32 9 9	9.2	CYB5A, CYP1A2, CYP1B1, CYP3A4, CYP2A6, CYP2B6
24	nifedipine32 9 9	9.1	CYP3A5, CYB5A, CYP1A2, CYP3A4, CYP17A1, CYP2A6
25	fluconazole32 9 9	9.1	CYP51A1, CYP3A4, CYP2A6, CYP2B6, CYP2C19, CYP19A1
26	midazolam32 9 9	8.9	CYP1A2, CYP1B1, CYP3A4, CYP2A6, CYP2B6, CYP2C19
27	paraxanthine32 18	7.6	CYP2A6, CYP2B6, CYP2C19, CYP4X1, CYP19A1, CYP3A5
28	linoleic acid32 18	7.6	CYP1A2, CYP1B1, CYP3A4, CYP3A43, CYP2A6, CYP2B6
29	tamoxifen32 34 9 9	9.6	CYB5A, CYP19A1, CYP3A5, CYP17A1, CYP2C19, CYP2B6
30	6-hydroxymelatonin32 18	7.6	CYP1A2, CYP1B1, CYP3A4, CYP3A43, CYP2A6, CYP2B6
31	citalopram32 34 9 18 9	10.6	CYP3A4, CYP3A43, CYP2A6, CYP2B6, CYP2C19, CYP4X1
32	parathion32 18	7.6	CYP2J2, CYP1A2, CYP1B1, CYP3A4, CYP3A43, CYP2A6
33	codeine32 34 9 18 9	10.6	CYP2J2, CYP3A5, CYP19A1, CYP1A2, CYP1B1, CYP3A4
34	Formic Acid9 18 9	8.4	CYP51A1, CYP1A2, CYP1B1, CYP3A4, CYP3A43, CYP2A6
35	estrone32 9 18 9	9.3	CYP1B1, CYP3A4, CYP3A43, CYP2A6, CYP2B6, CYP2C19
36	ketoconazole32 42 9 18 9	10.3	CYP1A2, CYP1B1, CYP3A4, CYP2A6, CYP2B6, CYP2C19
37	steroid32	6.1	CYP17A1, CYP21A2, FGFR1, POR, CYP2C19, CYP2B6
38	arachidonic acid32 9 18 9	9.1	FGFR2, CYB5A, CYP1A2, CYP1B1, CYP3A4, CYP3A43
39	oxygen32 18	7.1	CYP17A1, CYP21A2, CYP3A5, CYP2J2, NSDHL, POR
40	progesterone32 42 9 18 9	10.1	CYP19A1, CYP17A1, CYP3A5, CYP21A2, CYP1B1, FGFR1
41	formaldehyde32 18	7.0	CYP3A43, CYP2A6, CYP2B6, CYP2C19, CYP4X1, CYP19A1
42	caffeine32 34 9 18 9	9.9	CYP1A2, CYP1B1, CYP4X1, CYP2C19, CYP2A6, CYP3A43
43	estradiol32 9 18 9	8.9	CYP19A1, CYP21A2, CYP3A5, POMC, CYP1A2, CYP1B1
44	valproic acid32 34 9 18 9	9.9	CYP19A1, CYP3A5, CYP2J2, POMC, CYP4X1, CYP2C19
45	nadph32 18	6.7	CYP2A6, CYP2B6, CYP2C19, CYCS, CYP4X1, CYP21A2
46	dexamethasone32 42 34 9 9	9.6	CYP1B1, POMC, CYP3A4, CYP3A43, CYP2A6, CYP2C19
47	retinoic acid32 42 18	7.4	FGFR1, FGFR2, CYP4X1, CYP1A2, CYP1B1, CYP3A4
48	androstenedione32 18	6.1	CYB5A, CYP1A2, CYP1B1, CYP3A4, POMC, POR
49	Heme9 18 9	7.0	CYP3A4, CYP3A43, CYP2A6, CYP2B6, CYP2C19, CYCS
50	testosterone32 9 18 9	7.7	CYP19A1, CYP21A2, CYP3A5, CYP2J2, POR, POMC

Cellular components related to antley-bixler syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intracellular membrane-bounded organelle	GO:043231	7.6	NSDHL, CYP3A5, CYP2C19, CYP2B6, CYP3A4, CYP1A2
2	endoplasmic reticulum membrane	GO:005789	4.6	CYB5A, POR, NSDHL, CYP2J2, CYP3A5, CYP21A2

Biological processes related to antley-bixler syndrome according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of steroid hormone biosynthetic process	GO:090031	10.4	POR, CYP17A1
2	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	GO:035607	10.4	FGFR2, FGFR1
3	ventricular zone neuroblast division	GO:021847	10.3	FGFR2, FGFR1
4	phthalate metabolic process	GO:018963	10.3	CYP19A1, CYP17A1
5	biphenyl metabolic process	GO:018879	10.3	CYP19A1, CYP17A1
6	positive regulation of phospholipase activity	GO:010518	10.2	FGFR2, FGFR1
7	response to herbicide	GO:009635	10.2	CYP19A1, CYP17A1
8	lung-associated mesenchyme development	GO:060484	10.1	FGFR1, FGFR2
9	glucocorticoid biosynthetic process	GO:006704	10.1	CYP21A2, CYP17A1
10	dibenzo-p-dioxin metabolic process	GO:018894	10.1	CYP19A1, CYP17A1, CYP1A2
11	cellular response to follicle-stimulating hormone stimulus	GO:071372	10.0	CYP19A1, POR
12	alkaloid catabolic process	GO:009822	9.8	CYP3A5, CYP3A4
13	mesenchymal cell differentiation	GO:048762	9.8	FGFR2, FGFR1
14	steroid catabolic process	GO:006706	9.8	CYP1A2, CYP3A4
15	drug catabolic process	GO:042737	9.6	CYP3A5, CYP3A4, CYP1A2
16	oxidative demethylation	GO:070989	9.6	CYP1A2, CYP3A4, CYP3A5
17	heterocycle metabolic process	GO:046483	9.1	CYP2C19, CYP3A4, CYP1A2
18	monoterpenoid metabolic process	GO:016098	9.1	CYP2C19, CYP3A4, CYP1A2
19	exogenous drug catabolic process	GO:042738	8.3	CYP2C19, CYP2B6, CYP2A6, CYP3A4, CYP1A2
20	drug metabolic process	GO:017144	8.3	CYP2C19, CYP2B6, CYP2A6, CYP3A4, CYP1A2
21	oxidation-reduction process	GO:055114	8.1	POR, CYP2C19, CYP2B6, CYP3A4, CYP1B1, CYP1A2
22	steroid metabolic process	GO:008202	7.7	CYP3A5, CYP21A2, CYP19A1, CYP17A1, CYP2C19, CYP2B6
23	xenobiotic metabolic process	GO:006805	6.2	CYP2J2, CYP51A1, CYP1A2, CYP1B1, CYP3A4, CYP3A43
24	small molecule metabolic process	GO:044281	4.6	POMC, NSDHL, CYP2J2, CYB5A, CYP51A1, CYP1A2

Molecular functions related to antley-bixler syndrome according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	fibroblast growth factor-activated receptor activity	GO:005007	10.0	FGFRL1, FGFR2, FGFR1
2	fibroblast growth factor binding	GO:017134	9.8	FGFR1, FGFR2, FGFRL1
3	caffeine oxidase activity	GO:034875	9.6	CYP1A2, CYP3A4
4	steroid hydroxylase activity	GO:008395	9.0	CYP21A2, CYP2C19, CYP3A4
5	aromatase activity	GO:070330	8.6	CYP2J2, CYP3A5, CYP19A1, CYP4X1, CYP3A43, CYP1B1
6	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavopr	GO:016712	8.4	CYP1B1, CYP3A4, CYP2A6, CYP2B6, CYP19A1, CYP1A2
7	oxygen binding	GO:019825	8.2	CYP3A5, CYP19A1, CYP17A1, CYP2C19, CYP3A4, CYP1B1
8	oxidoreductase activity	GO:016491	8.2	CYP3A5, CYP2C19, CYP3A4, CYP1A2
9	enzyme binding	GO:019899	8.0	CYB5A, CYP1A2, CYP3A4, CYP2A6, CYP2C19, POR
10	monooxygenase activity	GO:004497	7.5	CYP3A5, CYP2C19, CYP2B6, CYP3A43, CYP3A4, CYP1B1
11	electron carrier activity	GO:009055	5.7	POR, CYP1A2, CYP51A1, CYP1B1, CYP3A4, CYP3A43
12	iron ion binding	GO:005506	5.2	CYP4X1, CYCS, CYP2C19, CYP2B6, CYP2A6, CYP3A43
13	heme binding	GO:020037	5.1	CYP2J2, CYP3A5, CYP21A2, CYP19A1, CYP17A1, CYP4X1