MCID: ANR004
MIFTS: 55

Anuria malady

Nephrological diseases category

Summaries for Anuria

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63Wikipedia, 32MalaCards
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Wikipedia:63 Anuria means nonpassage of urine, in practice is defined as passage of less than 100 milliliters of... more...

MalaCards: Anuria, also known as suppression of urinary secretion, is related to uremia and hypertension. An important gene associated with Anuria is MB (myoglobin), and among its related pathways are Thromboxane signalling through TP receptor and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs mannitol and mannitol hexanitrate and the compounds norepinephrine and captopril have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and uterus, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Classifications for Anuria

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

anuria 8 10 44 60
suppression of urinary secretion 8


External Ids:

Disease Ontology8 DOID:2983
MeSH34 D001002

Related Diseases for Anuria

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17GeneCards, 18GeneDecks
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Diseases related to Anuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1uremia30.3ALB
2hypertension30.3HSD11B2, FBXL20, NR3C2, AGTR1, AGT, REN
3peritonitis30.3ALB, MB
4leukemia30.1NR3C2
5malignant hypertension30.1REN, ACE
6diarrhea30.1ALB
7oligohydramnios29.9ACE
8renal hypertension29.9ACE, REN
9renal tubular dysgenesis29.9AGTR1, AGT, REN
10proteinuria29.9HSD11B2, FBXL20, NR3C2, AGTR1, AGT, REN
11cushing's syndrome29.7REN, HSD11B2
12glomerulonephritis29.7ALB, AGTR1
13ovarian hyperstimulation syndrome29.7ALB, REN
14acute kidney failure29.7MB, REN, ALB
15nephrotic syndrome29.7ALB, ACE, AGT
16breast cancer29.7HSD11B2, NR3C2, AGT, ALB
17myocardial infarction29.7MB, NR3C2, AGTR1, AGT, REN, ACE
18ureteral obstruction10.4
19hemolytic-uremic syndrome10.2
20burns10.1
21purpura10.1
22acromegaly10.0HSD11B2
23glaucoma10.0HSD11B2
24eosinophilia10.0MB
25myocarditis10.0MB
26cor pulmonale10.0AGTR1
27intermediate coronary syndrome10.0MB
28mitral valve prolapse10.0AGTR1
29dementia10.0AGTR1
30fibromuscular dysplasia10.0REN
31amyotrophic lateral sclerosis10.0MB
32proliferative diabetic retinopathy10.0AGT
33hypoaldosteronism10.0REN
34acute pancreatitis10.0MB
35urinary tract obstruction10.0ACE
36polycystic ovary syndrome10.0NR3C2
37rheumatoid arthritis10.0MB
38dilated cardiomyopathy10.0MB, ACE
39lupus nephritis10.0ALB
40vesicoureteral reflux10.0AGTR1, AGT
41cholestasis10.0ALB
42hepatitis c10.0ALB
43pulmonary fibrosis10.0AGT, AGTR1
44low renin hypertension10.0HSD11B2, REN
45galactosemia10.0ALB
46cerebrovascular disease10.0ACE, AGTR1
47apparent mineralocorticoid excess syndrome10.0HSD11B2, NR3C2
48hyperhomocysteinemia10.0ALB
49pancreatitis10.0ALB
50adenocarcinoma10.0AGTR1, HSD11B2

Graphical network of the top 20 diseases related to Anuria:



Diseases related to anuria

Clinical Features for Anuria

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Drugs & Therapeutics for Anuria

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Anuria

Drug clinical trials:

Search ClinicalTrials for Anuria

Search NIH Clinical Center for Anuria

Search CenterWatch for Anuria

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Anuria

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Anatomical Context for Anuria

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32MalaCards
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MalaCards organs/tissues related to Anuria:

32
Kidney, Liver, Uterus, Heart, Placenta, Breast, Bone marrow, Skeletal muscle, Cortex, Bone, Cervix

Animal Models for Anuria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Anuria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6REN, AGT, NR3C2, MB, HSD11B2
2MP:00053857.6HSD11B2, MB, NR3C2, AGTR1, AGT, REN
3MP:00053677.5ALB, HSD11B2, NR3C2, AGTR1, AGT, REN
4MP:00053787.1MB, FBXL20, NR3C2, AGTR1, AGT, REN
5MP:00053767.0HSD11B2, MB, NR3C2, AGTR1, AGT, REN
6MP:00107686.7HSD11B2, MB, FBXL20, NR3C2, AGTR1, AGT

Publications for Anuria

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Sources:
50PubMed
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Articles related to Anuria:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Reflex anuria: an old concept with new evidence. (23979816)
2013
2
Neonate with abdominal lump and anuria. (20823988)
2010
3
Anuria in an infant secondary to bilateral ureteric stones. (20676719)
2010
4
Calculus anuria and its remedy. (21409919)
2010
5
An unusual case of bilateral primitive obstructed megaureters due to ureteral valves presenting with anuria at the age of 1 month. (18022421)
2007
6
Unusual causes of sudden anuria in renal transplant patients. (17496403)
2007
7
Anuria due to bilateral ureteral obstruction by Aspergillus flavus in an adult male. (11927329)
2002
8
Reflex anuria from unilateral ureteral obstruction. (11867959)
2002
9
Abdominal compartment syndrome and acute anuria. (9794580)
1998
10
Neonatal anuria by ACE inhibitors during pregnancy. (9200422)
1997
11
Reflex anuria. (7592301)
1995
12
Anuria due to intrarenal blood clots in solitary kidney after change of ureteral stent: resolution with minimally invasive evacuation. (7776422)
1995
13
Increased intraabdominal pressure and anuria in the newborn. (1941473)
1991
14
Renal hydatid disease presenting as anuria. (3191344)
1988
15
Anuria caused by renal artery stenosis. (2896187)
1988
16
Postpartum anuria caused by silent bilateral nephrolithiasis. (3425236)
1987
17
Equilibration, distribution, and elimination of a single dose of intravenous ethanol in dogs with intact renal function or anuria. (3526953)
1986
18
Prolonged anuria and aortic insufficiency in a child with Wegener's granulomatosis. (7067177)
1982
19
Clinicopathological Conference: Sudden anuria and renal failure in an elderly man. (6278163)
1982
20
Pharmacokinetics of vancomycin in anuria. (7342290)
1981
21
A case of non-agglutinable vibrio gastroenteritis with anuria. (875775)
1977
22
Anuria in a 30-month-old child. (4443233)
1974
23
Total anuria as a manifestation of spontaneous rupture of an apparently normal kidney: report of a case. (4855222)
1974
24
The surgical treatment of renal artery embolism with anuria. (5571162)
1971
25
Renal candidiasis. A cause of anuria. (5428688)
1970
26
A simple method for the production of anuria in mice. (6066832)
1967
27
Acute oligo-anuria in obstetrics and gynaecology. (5596688)
1967
28
ANURIA DUE TO ACUTE OCCLUSION OF THE ARTERY TO A SOLITARY KIDNEY, SUCCESSFUL TREATMENT BY OPERATIVE MEANS. (14279248)
1965
29
Anuria associated with severe gallbladder disease attack. (14469398)
1962
30
Anuria in patients with single functioning kidney. (13763811)
1960
31
Two cases of acute glomerular nephritis with severe oliguria or anuria for 75 days; clinical course, roentgenological studies on kidneys size, and post-mortem findings. (13544857)
1958
32
Exchange transfusions in the treatment of anuria]. (13528286)
1958
33
Can reserpine prevent anuria in shock. (13501908)
1957
34
Toxicity of carbutamide; report of a fatal case of bone-marrow depression and anuria. (13388033)
1957
35
Anuria ascribed to acute tubular necrosis in infancy and early childhood. (13395581)
1956
36
The treatment of anuria. (13194435)
1954
37
Reflex anuria. (13064749)
1953
38
Conservative therapy in 11 cases of acute anuria]. (13136563)
1953
39
Serum potassium patterns in anuria and oliguria. (13041036)
1953
40
Ion-exchange resins in the treatment of anuria. (13098082)
1953
41
The medical management of anuria and oliguria. (14938716)
1952
42
TREATMENT of anuria. (14935334)
1952
43
The preformed ammonia content of skeletal muscle and liver in experimental anuria. (14895464)
1951
44
Anuria. (14874696)
1951
45
The management of an unusual case of anuria. (14850901)
1951
46
Anuria and oliguria; treatment by conservative means, case report, with determination of blood volume and Na24 space. (15426982)
1950
47
Present day therapy of anuria. (15413747)
1950
48
Treatment of acute uraemia due to oliguria and anuria. (15390582)
1949
49
The treatment of anuria. (18890608)
1948
50
The therapeutic use of peritoneal lavage for anuria caused by toxic nephritis; report of a case. (18101063)
1948

Genetic Variations for Anuria

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Expression for genes affiliated with Anuria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anuria

Search GEO for disease gene expression data for Anuria.

Pathways for genes affiliated with Anuria

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Sources:
53Reactome, 12EMD Millipore, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Anuria

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Anuria according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.1MB, NR3C2
2captopril44 28 49 59 1114.1NR3C2, REN
3estradiol44 11 2412.0AGTR1, REN
4glycyrrhetinic acid44 2410.4NR3C2, REN, HSD11B2
5remikiren44 1110.4AGT, REN, ACE
6lacidipine449.4REN, ACE, AGTR1
7trandolapril44 1110.3ACE, REN, AGTR1
8pd12331944 2810.3AGTR1, ACE, AGT
9cilazapril44 1110.3REN, AGTR1, ACE
10inulin449.3REN, ALB, AGT
1111beta-hydroxysteroid449.2REN, HSD11B2, AGTR1, NR3C2
12indapamide44 1110.2ALB, REN, ACE
13doca449.2REN, NR3C2, HSD11B2
14aliskiren44 1110.2ACE, AGTR1, REN, AGT
15saralasin449.1AGTR1, AGT, ACE, REN
16enalaprilat449.1ACE, AGT, REN
17eprosartan44 28 1111.1ACE, AGTR1, AGT, REN
18benazepril44 1110.1AGT, REN, AGTR1, ACE
19olmesartan44 28 1111.1AGTR1, AGT, ACE, REN
20quinapril44 1110.1REN, ACE, AGTR1
21chymostatin449.1AGT, ACE, REN, AGTR1
22atenolol44 28 49 11 2413.1ACE, AGTR1, REN, AGT
23diltiazem44 28 1111.0REN, AGT, AGTR1, ACE
24eplerenone44 59 28 1112.0REN, ACE, NR3C2, AGTR1
25thiazide449.0AGTR1, NR3C2, REN, ACE
26glycyrrhizin44 2810.0NR3C2, HSD11B2, REN
27felodipine44 28 1111.0ACE, REN, NR3C2, AGTR1
28fosinopril44 1110.0REN, ALB, AGTR1, ACE
29ramipril44 119.9REN, ACE, ALB, AGTR1
30haloperidol44 28 2 49 1112.9MB, NR3C2, AGTR1, REN, AGT
31acth448.8AGT, AGTR1, NR3C2, REN, HSD11B2
32ang ii448.7ACE, REN, AGT, AGTR1, NR3C2
33furosemide44 49 59 28 11 2413.7ACE, REN, AGTR1, HSD11B2, ALB
34lisinopril44 11 2410.6AGT, ALB, ACE, AGTR1, REN
35valsartan44 59 28 1111.6AGT, REN, ALB, AGTR1, ACE
36perindopril44 49 1110.6AGTR1, ACE, ALB, REN, AGT
37telmisartan44 28 1110.6ALB, REN, AGT, ACE, AGTR1
38irbesartan44 28 49 1111.6ALB, ACE, REN, AGT, AGTR1
39candesartan44 28 1110.6REN, AGT, AGTR1, ALB, ACE
40enalapril44 49 1110.6AGT, ALB, ACE, AGTR1, REN
41amlodipine44 49 11 2411.6ACE, AGTR1, REN, ALB, AGT
42arginine448.3HSD11B2, AGT, NR3C2, MB, REN, AGTR1
43spironolactone49 44 59 28 1112.2HSD11B2, NR3C2, ALB, AGTR1, REN, ACE
44losartan44 49 28 1111.2ALB, NR3C2, AGTR1, ACE, REN, AGT
45hydrochlorothiazide44 49 28 11 2411.9NR3C2, HSD11B2, ACE, AGTR1, AGT, REN
46potassium44 11 249.8HSD11B2, NR3C2, ALB, ACE, REN, AGT
47sodium44 248.8REN, ALB, AGTR1, HSD11B2, AGT, ACE
48cholesterol44 28 11 2410.7ACE, ALB, NR3C2, HSD11B2, AGTR1, REN
49glucose447.6NR3C2, ACE, ALB, AGT, AGTR1, HSD11B2
50creatinine447.6ACE, HSD11B2, MB, NR3C2, AGTR1, REN

GO Terms for genes affiliated with Anuria

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16Gene Ontology
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Biological processes related to Anuria according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.0AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.0AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.0AGTR1, AGT
4positive regulation of cholesterol esterificationGO:0108739.9AGT, AGTR1
5low-density lipoprotein particle remodelingGO:0343749.9AGTR1, AGT
6positive regulation of cellular protein metabolic processGO:0322709.8AGTR1, AGT
7positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGT, AGTR1
8phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.8AGT, AGTR1
9regulation of renal output by angiotensinGO:0020199.7ACE, AGT
10regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.7ACE, AGTR1
11renin-angiotensin regulation of aldosterone productionGO:0020189.7REN, AGT, AGTR1
12positive regulation of reactive oxygen species metabolic processGO:20003799.7AGT, AGTR1
13regulation of vasodilationGO:0423129.7AGTR1, ACE
14regulation of vasoconstrictionGO:0192299.4AGTR1, AGT, ACE
15angiotensin maturationGO:0020039.4AGT, REN, ACE
16blood vessel remodelingGO:0019749.2ACE, AGT
17kidney developmentGO:0018229.0ACE, REN, AGT, AGTR1

Molecular functions related to Anuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:0106989.8AGT, AGTR1
2oxygen bindingGO:0198259.7ALB, MB
3bradykinin receptor bindingGO:0317119.4ACE, AGTR1
4steroid bindingGO:0054969.4NR3C2, HSD11B2

Products for genes affiliated with Anuria

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Sources for Anuria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet