MCID: ANX002
MIFTS: 73

Anxiety Disorder malady

Neuronal category

Summaries for Anxiety Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Fear and anxiety are part of life. you may feel anxious before you take a test or walk down a dark street. this kind of anxiety is useful - it can make you more alert or careful. it usually ends soon after you are out of the situation that caused it. but for millions of people in the united states, the anxiety does not go away, and gets worse over time. they may have chest pains or nightmares. they may even be afraid to leave home. these people have anxiety disorders. types include panic disorder obsessive-compulsive disorder post-traumatic stress disorder phobias generalized anxiety disorder treatment can involve medicines, therapy or both. nih: national institute of mental health

MalaCards: Anxiety Disorder, also known as anxiety disorders, is related to generalized anxiety disorder and panic disorder. An important gene associated with Anxiety Disorder is HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Enzymatic degradation of dopamine by COMT. The drugs amobarbital and diphenhydramine hydrochloride and the compounds mianserin and venlafaxine have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and brain, and related mouse phenotypes are renal/urinary system and muscle.

Disease Ontology:8 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:64 Anxiety disorder is an umbrella term that covers several different forms of a type of common mental... more...

Aliases & Classifications for Anxiety Disorder

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 34MedlinePlus, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

anxiety disorder 8 22 10
anxiety disorders 45 61
anxiety neurosis 61
anxiety state 8
anxiety 34


External Ids:

Disease Ontology8 DOID:2030
MeSH35 D001008
NCIt40 C2878
ICD1025 F41.8, F41.9

Related Diseases for Anxiety Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Anxiety Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 418)
idRelated DiseaseScoreTop Affiliating Genes
1generalized anxiety disorder31.9TSPO, HTR1A, SLC6A4
2panic disorder31.2CCKBR, HTR3A, CRH, SLC6A4, TSPO, HTR1A
3social phobia31.0COMT, HTR1A, HTR3A, OXT, MAOA, SLC6A4
4bipolar disorder30.9HTR1A, SLC6A4
5obsessive-compulsive disorder30.9COMT, HTR1A, HTR3A, TPH2, TPH1, TSPO
6agoraphobia30.7SLC6A2, MAOA, CCKBR, HTR1A
7alcohol dependence30.7MAOA, CRH, DRD4, NPY, HTR2A, CNR1
8dysthymic disorder30.4HTR2A, MAOA
9substance abuse30.4SLC6A4, SLC6A3, CNR1, CRH, DRD4
10nicotine dependence30.3DRD4, SLC6A4
11antisocial personality disorder30.3HTR2A, SLC6A4, SLC6A3, MAOA
12attention deficit hyperactivity disorder30.3DRD4, SLC6A3
13irritable bowel syndrome30.2HTR3A, CRH, SLC6A4, TPH1
14alcohol abuse30.2SLC6A3, COMT, SLC6A4
15narcolepsy30.2HTR2A, COMT
16withdrawal disorder30.2CRH, CNR1
17anorexia nervosa30.2SLC6A4, CNR1, MAOA, OXT, CRH, DRD4
18pathological gambling30.1SLC6A3, DRD4
19borderline personality disorder30.1OXT, TPH1, SLC6A4, MAOA
20conduct disorder30.1DRD4, SLC6A4, COMT, MAOA, SLC6A3
21substance dependence30.1CNR1, SLC6A3, DRD4, COMT, SLC6A4, TPH1
22premature ejaculation30.1HTR1A, SLC6A4
23memory impairment30.1TSPO, HTR1A, SLC6A3, HTR2A, CNR1
24melancholia30.0MAOA, CRH
25bulimia nervosa30.0MAOA, NPY, HTR2A, HTR3A, COMT, SLC6A4
26dyspepsia29.9HTR3A
27neuroleptic malignant syndrome29.9HTR1A
28chronic fatigue syndrome29.9HTR1A, SLC6A4, MAOA, CRH
29schizoaffective disorder29.9SLC6A4, HTR2A, COMT, DRD4
30parkinson's disease29.9SLC6A3, CNR1, MAOA, HTR1A, COMT
31autistic disorder29.9HTR2A, OXT, HTR1A, HTR3A, SLC6A4
32fibromyalgia29.9TSPO, SLC6A4, CRH, NPY, HTR2A, HTR3A
33cannabis dependence29.9CNR1
34asthma29.9CNR1, TSPO, HTR2A
35paranoid schizophrenia29.8COMT
36serotonin syndrome29.8HTR3A, HTR1A, MAOA, HTR2A
37phaeochromocytoma29.8NPY
38temporal lobe epilepsy29.8TSPO, NPY, HTR1A
39seasonal affective disorder29.8TPH1, SLC6A4, CRH, DRD4, HTR2A, HTR1A
40gilles de la tourette syndrome29.6DRD4, SLC6A3
41cocaine abuse29.6SLC6A3, HTR3A, SLC6A4
42amyotrophic lateral sclerosis29.6TSPO, SLC6A3, CNR1
43progressive supranuclear palsy29.6SLC6A3
44acute myocardial infarction29.6HTR2A, HTR3A, SLC6A4
45atherosclerosis29.6CNR1, HTR3A, COMT
46status epilepticus29.6NPY, CNR1
47cadasil29.6CNR1, HTR1A, HTR2A, TSPO, HTR3A
48pheochromocytoma29.6NPY, SLC6A3, OXT, COMT, CRH, SLC6A2
49alzheimer's disease29.6COMT, HTR2C, TSPO, SLC6A4, SLC6A3, HTR1A
50separation anxiety disorder10.9

Graphical network of the top 20 diseases related to Anxiety Disorder:



Diseases related to anxiety disorder

Clinical Features for Anxiety Disorder

Drugs & Therapeutics for Anxiety Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Anxiety Disorder

Search NIH Clinical Center for Anxiety Disorder

Highlights from CenterWatch's Drugs in Clinical Trials Database for Anxiety Disorder:

idCompanyCompoundMechanismPhase
1Ironwood PharmaceuticalsIW-2143/BNC210A small molecule anxiolyticI
2Pherin PharmaceuticalsAloradine nasal sprayAn intranasal spray that acts with rapid-onset on peripheral receptors from nasal chemosensory neurons IIb
3Janssen Pharmaceuticals/Addex PharmaceuticalsJNJ-40411813A mGluR2 positive allosteric modulatorII

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Anxiety Disorder

Sources:
22GTR
See all sources

Genetic tests related to Anxiety Disorder:

id Genetic test Affiliating Genes
1 Anxiety22

Anatomical Context for Anxiety Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Anxiety Disorder:

33
Ovary, Liver, Brain, Lung, Whole blood, Cortex, Heart, Thyroid, Prostate, Monocytes, Fetal brain, Prefrontal cortex, Cingulate cortex, Temporal lobe, Hypothalamus, Amygdala, Fetal liver, Fetal lung, Fetal thyroid, Adrenal cortex, Pituitary

Animal Models for Anxiety Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Anxiety Disorder

Sources:
51PubMed
See all sources

Articles related to Anxiety Disorder:

(show top 50)    (show all 1250)
idTitleAuthorsYear
1
The clinical impact of mood disorder comorbidity on social anxiety disorder. (24262120)
2014
2
Reduced anterior temporal and hippocampal functional connectivity during face processing discriminates individuals with social anxiety disorder from healthy controls and panic disorder, and increases following treatment. (24084831)
2014
3
The prevalence of depression and anxiety disorders in patients with euthyroid Hashimoto's thyroiditis: a comparative study. (24211158)
2014
4
Body image in social anxiety disorder, obsessive-compulsive disorder, and panic disorder. (24095651)
2014
5
Comorbid social withdrawal (hikikomori) in outpatients with social anxiety disorder: clinical characteristics and treatment response in a case series. (21997765)
2013
6
Comorbidity of social anxiety disorder and antisocial personality disorder in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). (24384071)
2013
7
Trait anxiety modulates fronto-limbic processing of emotional interference in borderline personality disorder. (23459637)
2013
8
Assessing eating disorder risk: the pivotal role of achievement anxiety, depression and female gender in non-clinical samples. (23482057)
2013
9
Measuring Anxiety as a Treatment Endpoint in Youth with Autism Spectrum Disorder. (24158679)
2013
10
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. (23607501)
2013
11
Using a hybrid model to investigate the comorbidity and symptom overlap between social phobia and the other anxiety disorders and unipolar mood disorders. (23809463)
2013
12
A Bowen Family Systems Model of Generalized Anxiety Disorder and Romantic Relationship Distress. (24372281)
2013
13
Increased risk of lichen simplex chronicus in people with anxiety disorder: A nationwide population-based retrospective cohort study. (24372057)
2013
14
Anxiety disorders are independently associated with suicide ideation and attempts: propensity score matching in two epidemiological samples. (24108489)
2013
15
rTMS to treat social anxiety disorder: a case report. (23567611)
2013
16
Cognitive-behavioral therapy modifies the naturalistic course of social anxiety disorder: findings from an ABA design study in routine clinical practices. (23581864)
2013
17
Treating individuals with social anxiety disorder and at-risk drinking: phasing in a brief alcohol intervention following paroxetine. (23523988)
2013
18
Myocardial infarction and generalised anxiety disorder: 10-year follow-up. (22403086)
2012
19
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. (22542862)
2012
20
Outcome predictors in guided and unguided self-help for social anxiety disorder. (22134140)
2012
21
Generalized anxiety disorder: is there any specific symptom? (22578985)
2012
22
Interpretation training in individuals with generalized social anxiety disorder: a randomized controlled trial. (22250851)
2012
23
Hypochondriasis, somatoform disorders, and anxiety disorders: sociodemographic variables, general psychopathology, and naturalistic treatment effects. (22551794)
2012
24
Is agoraphobia the same thing as social anxiety disorder? (23045742)
2012
25
Statistical alchemy for drug treatment of generalized anxiety disorder: a commentary on the meta-analysis by Baldwin et al. [BMJ 2011;342:d1199]. (21654185)
2011
26
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. (22047726)
2011
27
The clinical course of body dysmorphic disorder in the Harvard/Brown Anxiety Research Project (HARP). (21206248)
2011
28
The metacognitive model of generalized anxiety disorder in children and adolescents. (20352491)
2010
29
Double-blind comparison of 30 and 60 mg tranylcypromine daily in patients with panic disorder comorbid with social anxiety disorder. (20036427)
2010
30
Posterior orbitofrontal sulcogyral pattern associated with orbitofrontal cortex volume reduction and anxiety trait in panic disorder. (20602731)
2010
31
Generalized anxiety disorder and medical illness. (19371503)
2009
32
Current theoretical models of generalized anxiety disorder (GAD): conceptual review and treatment implications. (19700258)
2009
33
Anxiety in boys with attention-deficit/hyperactivity disorder with and without chronic multiple tic disorder. (20035592)
2009
34
Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder. (19125211)
2009
35
Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder. (19180583)
2009
36
Differential efficacy of memantine for obsessive-compulsive disorder vs. generalized anxiety disorder: an open-label trial. (19204653)
2009
37
Implications of pain in generalized anxiety disorder: efficacy of duloxetine. (18615176)
2008
38
Gender differences in generalized anxiety disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). (19192444)
2008
39
The effectiveness of anxiety treatment on alcohol-dependent patients with a comorbid phobic disorder: a randomized controlled trial. (15897725)
2005
40
Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms. (15830231)
2005
41
Functional regulation of serotonin transporter, a molecule involved in the pathogenesis of anxiety disorder]. (15291238)
2004
42
The molecular neuroimaging of anxiety disorders. (15260943)
2004
43
Drug development for anxiety disorders: new roles for atypical antipsychotics. (15278017)
2004
44
Inverse agonist binding of peripheral benzodiazepine receptors in anxiety disorder. (11697575)
2001
45
The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. (10599479)
1999
46
Social anxiety disorder: designing a pharmacologic treatment strategy. (10335676)
1999
47
Association between anxiety disorders and a functional polymorphism in the serotonin transporter gene. (9858044)
1998
48
Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis. (9399689)
1997
49
The cholecystokinin hypothesis of anxiety and panic disorder. (8185169)
1994
50
Anxiety and adjustment disorder: a treatment approach. (2228990)
1990

Genetic Variations for Anxiety Disorder

Expression for genes affiliated with Anxiety Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anxiety Disorder

Search GEO for disease gene expression data for Anxiety Disorder.

Pathways for genes affiliated with Anxiety Disorder

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Anxiety Disorder according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4SLC6A4, SLC6A2
2
Hide members
10.4SLC6A3, MAOA
3
Hide members
10.4TPH1, TPH2
4
Hide members
10.4TPH1, TPH2
5
Hide members
10.4TPH1, TPH2
6
Hide members
10.3TPH2, TPH1, MAOA
7
Hide members
10.3TPH2, TPH1, MAOA
810.3DRD4, HTR2A, CCKBR
910.2SLC6A3, MAOA, CRH, NPY
1010.2SLC6A3, SLC6A4, SLC6A2, TPH2
11
Hide members
10.2CCKBR, HTR2C, HTR2A, OXT
1210.1HTR1A, HTR3A, HTR2A, MAOA, SLC6A4, TPH1
13
Hide members
10.1SLC6A4, HTR2C, HTR1A, HTR3A, HTR2A, DRD4
14
Hide members
9.9CCKBR, HTR2C, HTR1A, HTR2A, NPY, DRD4
15
Hide members
9.9COMT, HTR2C, HTR1A, HTR3A, HTR2A, DRD4
16
Hide members
9.8HTR2A, HTR1A, HTR2C, CCKBR, NPY, DRD4

Compounds for genes affiliated with Anxiety Disorder

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Anxiety Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 362)
idCompoundScoreTop Affiliating Genes
1mianserin29 45 1112.5HTR2C, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
2venlafaxine50 45 11 2413.5HTR1A, HTR3A, HTR2A, SLC6A3, SLC6A4, SLC6A2
3mdma4510.5TPH1, MAOA, SLC6A3, SLC6A4, SLC6A2, HTR1A
4sertraline45 29 50 11 2414.5SLC6A4, SLC6A2, SLC6A3, MAOA, HTR1A, HTR3A
5nefazodone45 50 1112.5HTR2C, HTR1A, HTR3A, HTR2A, SLC6A3, SLC6A4
6p-chloroamphetamine4510.5MAOA, HTR1A, SLC6A3, SLC6A4, SLC6A2
75-hydroxytryptophan4510.5HTR3A, HTR2A, HTR1A, TPH1, SLC6A4, CRH
8carbon-114510.5HTR1A, MAOA, SLC6A4, SLC6A3, TSPO
9mhpg4510.5COMT, NPY, DRD4, CRH, MAOA, SLC6A4
10amitriptyline45 50 29 1113.4SLC6A3, SLC6A2, SLC6A4, HTR2A, HTR3A, HTR1A
11fluvoxamine45 50 1112.4HTR1A, HTR3A, HTR2A, MAOA, SLC6A3, SLC6A4
12methamphetamine45 50 1112.4DRD4, MAOA, SLC6A3, SLC6A4, SLC6A2, TPH1
13desipramine45 50 1112.4HTR1A, HTR2A, CRH, MAOA, CNR1, SLC6A3
14yohimbine45 29 2 1113.4HTR1A, HTR2C, CCKBR, HTR3A, NPY, CRH
15citalopram50 45 11 2413.4HTR2C, HTR1A, HTR3A, HTR2A, MAOA, SLC6A3
16homovanillic acid45 2411.4COMT, TPH1, MAOA, SLC6A2, SLC6A4, CRH
17methylphenidate45 50 1112.4SLC6A4, SLC6A3, MAOA, DRD4, SLC6A2, COMT
18mirtazapine50 45 1112.4HTR2A, SLC6A4, HTR3A, TPH2, HTR2C, CRH
19nmda45 2911.4HTR1A, TSPO, SLC6A3, CNR1, MAOA, COMT
20fenfluramine29 45 1112.4NPY, CRH, SLC6A4, TPH1, TPH2, HTR2A
21risperidone29 45 50 60 11 2415.4COMT, HTR2C, HTR1A, HTR3A, HTR2A, DRD4
22m-chlorophenylpiperazine4510.4HTR1A, HTR2C, SLC6A4, HTR2A, HTR3A
235-hydroxyindoleacetic acid45 2411.4TPH1, SLC6A2, SLC6A4, MAOA, HTR3A, CRH
24pramipexole45 50 29 1113.4COMT, HTR1A, HTR2A, DRD4, SLC6A3, HTR2C
25amphetamine45 1111.4MAOA, CNR1, SLC6A3, SLC6A4, SLC6A2, TPH1
26apomorphine45 29 1112.3COMT, HTR2C, HTR1A, HTR2A, DRD4, OXT
27haloperidol45 29 2 50 1114.3CCKBR, HTR1A, HTR3A, HTR2A, NPY, DRD4
283,4-Methylenedioxymethamphetamine1110.3HTR2C, HTR2A, SLC6A3, SLC6A4, SLC6A2
29levodopa45 1111.3COMT, HTR1A, DRD4, MAOA, CNR1, SLC6A3
30clozapine45 29 50 1113.3HTR3A, HTR2A, DRD4, SLC6A3, SLC6A4, HTR1A
31paroxetine45 50 29 1113.3COMT, HTR1A, HTR3A, HTR2A, DRD4, MAOA
32quinpirole45 2911.3SLC6A3, RGS2, HTR2C, CNR1, DRD4, HTR2A
33clomipramine45 50 1112.3SLC6A3, SLC6A4, SLC6A2, TSPO, MAOA, CRH
34maoa4510.3COMT, HTR2C, HTR1A, HTR2A, DRD4, MAOA
35MMDA1110.3MAOA, SLC6A3, SLC6A4, SLC6A2, HTR2A
36olanzapine50 45 29 11 2414.3DRD4, HTR2A, HTR1A, HTR2C, HTR3A, SLC6A3
37acetylcholine45 50 29 11 2414.2HTR1A, HTR3A, NPY, CRH, CNR1, SLC6A3
38imipramine45 50 29 11 2414.2HTR2A, SLC6A2, SLC6A4, SLC6A3, MAOA, HTR3A
39mcpp4510.2HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
40duloxetine45 50 29 1113.2SLC6A2, SLC6A3, HTR2A, HTR2C, SLC6A4
41cocaine45 1111.2COMT, CCKBR, HTR2C, NPY, DRD4, CRH
42fluoxetine50 45 29 1113.1HTR2A, CRH, OXT, MAOA, CNR1, SLC6A3
43d amphetamine4510.1MAOA, SLC6A3, SLC6A2, TSPO, SLC6A4
44gaba4510.1TPH1, NPY, DRD4, CRH, HTR3A, OXT
45nicotine45 50 29 1113.1TSPO, SLC6A2, SLC6A4, NPY, SLC6A3, TPH1
46glutamate4510.0MAOA, OXT, CRH, DRD4, NPY, HTR2C
475-hydroxytryptamine459.9CRH, MAOA, CNR1, SLC6A3, SLC6A4, SLC6A2
48norepinephrine45 11 2411.9COMT, HTR2C, HTR1A, HTR3A, HTR2A, NPY
49dopamine45 29 11 2412.8TPH1, TSPO, SLC6A2, SLC6A4, SLC6A3, CNR1
50bupropion45 50 11 2412.8COMT, SLC6A2, SLC6A4, SLC6A3, CNR1, NPY

GO Terms for genes affiliated with Anxiety Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.7CCKBR, HTR2C, HTR1A, HTR3A, HTR2A, DRD4
2integral to plasma membraneGO:0058879.6SLC6A2, CCKBR, HTR2C, HTR1A, HTR3A, HTR2A

Biological processes related to Anxiety Disorder according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:01406210.7CRH, HTR1A
2phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.7HTR2A, HTR2C
3monoamine transportGO:01584410.7SLC6A2, SLC6A4, SLC6A3
4regulation of hormone secretionGO:04688310.7HTR1A, HTR2A
5dopamine catabolic processGO:04242010.7SLC6A3, MAOA, COMT
6regulation of dopamine metabolic processGO:04205310.7HTR1A, DRD4, SLC6A3
7neurotransmitter biosynthetic processGO:04213610.7COMT, MAOA, SLC6A3
8serotonin biosynthetic processGO:04242710.7TPH1, TPH2
9serotonin receptor signaling pathwayGO:00721010.7HTR2C, HTR1A, HTR3A, HTR2A
10agingGO:00756810.7HTR2A, CNR1, TSPO
11aromatic amino acid family metabolic processGO:00907210.7TPH1, TPH2
12response to painGO:04826510.7SLC6A2, CRH, COMT
13behavioral fear responseGO:00166210.7DRD4, HTR1A, HTR2C
14response to immobilization stressGO:03590210.6CRH, TPH1
15feeding behaviorGO:00763110.6CCKBR, HTR2C, NPY, CRH
16positive regulation of phosphatidylinositol biosynthetic processGO:01051310.6HTR2C, HTR2A
17behaviorGO:00761010.6NPY, MAOA, CNR1
18response to etherGO:04547210.6CRH, OXT
19negative regulation of blood pressureGO:04577610.6CRH, OXT, CNR1
20response to cocaineGO:04222010.6HTR3A, OXT, CNR1, SLC6A3
21indolalkylamine biosynthetic processGO:04621910.6TPH1, TPH2
22social behaviorGO:03517610.6SLC6A4, OXT, DRD4
23memoryGO:00761310.6SLC6A4, CNR1, OXT, HTR2A
24circadian rhythmGO:00762310.6TPH2, TPH1, SLC6A4
25sperm ejaculationGO:04271310.5SLC6A4, OXT
26neurotransmitter catabolic processGO:04213510.5MAOA, COMT
27digestionGO:00758610.5NPY, HTR3A, CCKBR
28sleepGO:03043110.5HTR2A, OXT
29response to drugGO:04249310.5COMT, HTR2C, HTR2A, CRH, SLC6A3, SLC6A4
30cellular calcium ion homeostasisGO:00687410.4DRD4, HTR2A, HTR2C
31synaptic transmissionGO:00726810.4SLC6A2, COMT, HTR2C, HTR3A, HTR2A, NPY
32response to ethanolGO:04547110.3CRH, CNR1, SLC6A3
33regulation of behaviorGO:05079510.3HTR1A, HTR2A
34response to stressGO:00695010.3TPH2, CNR1, HTR2A
35female pregnancyGO:00756510.3COMT, CRH, OXT
36synaptic transmission, dopaminergicGO:00196310.0DRD4, CRH

Molecular functions related to Anxiety Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.4SLC6A3, SLC6A4, SLC6A2
2serotonin receptor activityGO:00499310.4HTR2C, HTR1A, HTR3A, HTR2A
3dopamine bindingGO:03524010.3SLC6A3, DRD4
4serotonin bindingGO:05137810.3HTR2A, HTR3A, HTR2C
5drug bindingGO:00814410.3SLC6A3, CNR1, DRD4, HTR2A, HTR2C
61-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:07188610.3HTR2C, HTR2A
7tryptophan 5-monooxygenase activityGO:00451010.1TPH1, TPH2

Products for genes affiliated with Anxiety Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anxiety Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet