MCID: ANX002
MIFTS: 68

Anxiety Disorder malady

Mental diseases, Neuronal diseases categories
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Summaries for Anxiety Disorder

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Fear and anxiety are part of life. you may feel anxious before you take a test or walk down a dark street. this kind of anxiety is useful - it can make you more alert or careful. it usually ends soon after you are out of the situation that caused it. but for millions of people in the united states, the anxiety does not go away, and gets worse over time. they may have chest pains or nightmares. they may even be afraid to leave home. these people have anxiety disorders. types include panic disorder obsessive-compulsive disorder post-traumatic stress disorder phobias generalized anxiety disorder treatment can involve medicines, therapy or both. nih: national institute of mental health

MalaCards: Anxiety Disorder, also known as anxiety disorders, is related to generalized anxiety disorder and panic disorder. An important gene associated with Anxiety Disorder is TSPO (translocator protein (18kDa)), and among its related pathways are Venlafaxine Pathway, Pharmacokinetics and Monoamine GPCRs. The drugs chlordiazepoxide and chlordiazepoxide hydrochloride and the compounds p-chlorophenylalanine and milnacipran have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are nervous system and cardiovascular system.

Disease Ontology:8 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:65 Anxiety disorders are a group of mental disorders characterized by feelings of anxiety and fear, where... more...

Aliases & Classifications for Anxiety Disorder

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

anxiety disorder 8 22 10
anxiety disorders 45 62
anxiety neurosis 62
anxiety state 8
anxiety 34


External Ids:

Disease Ontology8 DOID:2030
NCIt40 C2878
MeSH35 D001008
ICD1025 F41.8, F41.9

Related Diseases for Anxiety Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anxiety Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1generalized anxiety disorder32.0TSPO, SLC6A4, HTR1A
2panic disorder31.2TSPO, HTR1A, SLC6A4, CCKBR
3social phobia31.0SLC6A4, MAOA, HTR1A
4bipolar disorder30.8SLC6A4, HTR2A
5personality disorder30.7MAOA, TPH1, SLC6A4
6agoraphobia30.7MAOA, HTR1A, CCKBR, SLC6A2
7obsessive-compulsive disorder30.6SLC6A4, SLC6A2, MAOA, HTR1A, HTR2A, TSPO
8substance abuse30.6SLC6A4
9alcohol dependence30.5HTR2A, SLC6A4, MAOA
10dysthymic disorder30.4HTR2A, MAOA
11eating disorder30.3HTR1A, SLC6A4, HTR2A
12irritable bowel syndrome30.3TPH1, SLC6A4
13oppositional defiant disorder30.3SLC6A2
14antisocial personality disorder30.3HTR2A, MAOA, SLC6A4
15mood disorder30.2HTR2A, TPH1, SLC6A4, HTR1A, MAOA, SLC6A2
16attention deficit hyperactivity disorder30.2HTR2A, MAOA, SLC6A4, SLC6A2
17drug dependence30.1MAOA, SLC6A4
18borderline personality disorder30.1SLC6A4, MAOA, TPH1
19neuroleptic malignant syndrome30.0HTR1A
20dementia30.0MAOA, HTR2A, TSPO, HTR1A
21anorexia nervosa30.0TPH1, SLC6A2, SLC6A4, HTR2A, HTR1A, MAOA
22substance dependence30.0TPH1, SLC6A4
23bulimia nervosa29.9HTR2A, MAOA, SLC6A4
24schizoaffective disorder29.9HTR2A, SLC6A4
25conduct disorder29.9MAOA, SLC6A4
26fibromyalgia29.9SLC6A4, HTR2A, TSPO
27schizophrenia29.9CCKBR, HTR1A, MAOA, SLC6A2, HTR2A, TPH1
28chronic fatigue syndrome29.9SLC6A4, HTR1A, MAOA
29psychotic disorder29.7TPH1, HTR2A, HTR1A, MAOA, SLC6A4
30parkinson's disease29.5MAOA, SLC6A4, SLC6A2, HTR2A, TPH1, TSPO
31separation anxiety disorder10.9
32major depressive disorder10.7
33blindness10.7
34specific phobia10.4
35hypochondriasis10.4
36insomnia10.4
37bipolar i disorder10.3
38phobic disorder10.3
39post-traumatic stress disorder10.2
40mutism10.2
41hypermobility syndrome10.2
42nicotine dependence10.2
43narcolepsy10.2
44avoidant personality disorder10.2
45mitral valve prolapse10.2
46body dysmorphic disorder10.2
47thyroiditis10.2
48alcoholic psychosis10.1SLC6A4
49obsessive-compulsive personality disorder10.1
50neurotic disorder10.1

Graphical network of the top 20 diseases related to Anxiety Disorder:



Diseases related to anxiety disorder

Symptoms for Anxiety Disorder

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Genetic Tests for Anxiety Disorder

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Sources:
22GTR
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Genetic tests related to Anxiety Disorder:

id Genetic test Affiliating Genes
1 Anxiety22

Anatomical Context for Anxiety Disorder

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Sources:
33MalaCards
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MalaCards organs/tissues related to Anxiety Disorder:

33
Heart, Testes, Brain, Cortex, Amygdala, Cingulate cortex, Prefrontal cortex, Eye, Thyroid, Prostate, Liver, Hypothalamus, Temporal lobe, Lung, Fetal brain, Monocytes, Ovary, Pituitary

Animal Models for Anxiety Disorder or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Anxiety Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8SLC6A2, SLC6A4, MAOA, HTR1A, CCKBR
2MP:00053857.3TPH1, CCKBR, HTR1A, MAOA, SLC6A4, SLC6A2
3MP:00053767.1TPH1, CCKBR, HTR1A, MAOA, SLC6A4, SLC6A2
4MP:00053866.7SLC6A2, TPH1, CCKBR, HTR2A, HTR1A, MAOA

Publications for Anxiety Disorder

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Sources:
52PubMed
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Articles related to Anxiety Disorder:

(show top 50)    (show all 1051)
idTitleAuthorsYear
1
Emotional reasoning and anxiety sensitivity: associations with social anxiety disorder in childhood. (24120086)
2014
2
Clinical experiences in conducting empirically supported treatments for generalized anxiety disorder. (24411110)
2014
3
Comorbid social withdrawal (hikikomori) in outpatients with social anxiety disorder: clinical characteristics and treatment response in a case series. (21997765)
2013
4
Adult separation anxiety disorder in DSM-5. (23673209)
2013
5
Comorbidity of social anxiety disorder and antisocial personality disorder in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). (24384071)
2013
6
Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety disorder. (22130178)
2013
7
Social anxiety and social anxiety disorder. (23537485)
2013
8
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
9
Is adolescent generalized anxiety disorder a magnet for negative parental interpersonal behaviors? (23390021)
2013
10
The effect of escitalopram on metabolic parameters in patients with major depressive disorder, generalised anxiety disorder, and panic disorder: a prospective 6-month follow-up study. (23642988)
2013
11
Evaluation of the proposed social anxiety disorder specifier change for DSM-5 in a treatment-seeking sample of anxious youth. (23494954)
2013
12
Commitment to a purpose in life: An antidote to the suffering by individuals with social anxiety disorder. (23795592)
2013
13
An investigator-blinded, randomized study to compare the efficacy of combined CBT for alcohol use disorders and social anxiety disorder versus CBT focused on alcohol alone in adults with comorbid disorders: the Combined Alcohol Social Phobia (CASP) trial protocol. (23895258)
2013
14
Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. (22116310)
2012
15
Pregabalin versus SSRIs and SNRIs in benzodiazepine-refractory outpatients with generalized anxiety disorder: a post hoc cost-effectiveness analysis in usual medical practice in Spain. (22745564)
2012
16
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
17
Panic-focused psychodynamic psychotherapy in a woman with panic disorder and generalized anxiety disorder. (23030215)
2012
18
Are children with "pure" generalized anxiety disorder impaired? A comparison with comorbid and healthy children. (22963176)
2012
19
Generalized anxiety disorder and the proposed associated symptoms criterion change for DSM-5 in a treatment-seeking sample of anxious youth. (22952043)
2012
20
A parent-child interactional model of social anxiety disorder in youth. (22116625)
2012
21
Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder. (22320999)
2012
22
Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder. (21872345)
2011
23
Association between generalized anxiety disorder and asthma morbidity. (21715294)
2011
24
Cognitive-Behavioral Therapy for Immigrants Presenting With Social Anxiety Disorder: Two Case Studies. (22844232)
2011
25
Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. (20439149)
2010
26
A multicenter, placebo-controlled, double-blind, randomized study of efficacy and safety of ocinaplon (DOV 273,547) in generalized anxiety disorder. (20041911)
2010
27
Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. (20123913)
2010
28
Management of generalized anxiety disorder in primary care: identifying the challenges and unmet needs. (20694114)
2010
29
Understanding behavior: generalized anxiety disorder. (20180208)
2009
30
Pharmacotherapy for social anxiety disorder: an update. (19728573)
2009
31
Panic disorder and social anxiety disorder subtypes in a caffeine challenge test. (19698996)
2009
32
How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale. (19273493)
2009
33
Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: a randomized, controlled trial. (19570931)
2009
34
Is hypochondriasis an anxiety disorder? (19478284)
2009
35
Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence. (18399707)
2008
36
A preliminary study of fMRI-guided rTMS in the treatment of generalized anxiety disorder. (18572984)
2008
37
Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial. (18344738)
2008
38
Anxiety disorder comobidity in Bipolar I Disorder: relationship to depression severity and treatment outcome. (15786484)
2005
39
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
40
New pharmacological treatment approaches for anxiety disorders. (16594270)
2005
41
Separation anxiety disorder. (15768687)
2005
42
The Nottingham Study of Neurotic Disorder: predictors of 12-year outcome of dysthymic, panic and generalized anxiety disorder. (15724870)
2004
43
Associations between juvenile and adult forms of separation anxiety disorder: a study of adult volunteers with histories of school refusal. (12080215)
2002
44
Separation anxiety disorder: planning treatment. (10878189)
2000
45
No association between anxiety disorders and catechol-O-methyltransferase polymorphism. (9754693)
1998
46
Two cases of essential myoclonus, epilepsy, mental retardation and anxiety disorders. (9339874)
1997
47
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
48
5-HT1A receptor sensitivity in depression and anxiety disorders: molecular mechanisms of neuroadaption. (1498813)
1992
49
5-HT1A receptor responsivity in anxiety disorders and depression. (1763190)
1991
50
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988

Variations for Anxiety Disorder

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Expression for genes affiliated with Anxiety Disorder

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Anxiety Disorder

Search GEO for disease gene expression data for Anxiety Disorder.

Pathways for genes affiliated with Anxiety Disorder

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Sources:
50PathCards, 51PharmGKB, 55Reactome, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Anxiety Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SLC6A2, SLC6A4
2
Show member pathways
9.5HTR1A, HTR2A
3
Show member pathways
9.2MAOA, TPH1
4
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)38
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA38
tryptophan degradation38
glutaryl-CoA degradation38
serotonin degradation38
NAD de novo biosynthesis38
superpathway of melatonin degradation38
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde38
tryptophan utilization I38
melatonin degradation I38
9.2MAOA, TPH1
5
Show member pathways
catecholamine biosynthesis38
9.2MAOA, TPH1
6
Show member pathways
Serotonin Transporter Activity38
8.7MAOA, SLC6A4, SLC6A2
7
Show member pathways
8.6TSPO, CCKBR, HTR2A, HTR1A
8
Show member pathways
7.7SLC6A4, MAOA, HTR1A, HTR2A, TPH1
97.7SLC6A4, MAOA, HTR1A, HTR2A, TPH1
107.7TPH1, HTR2A, HTR1A, MAOA, SLC6A4

Compounds for genes affiliated with Anxiety Disorder

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Anxiety Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1p-chlorophenylalanine459.5HTR1A, SLC6A4, TPH1
2milnacipran45 51 1111.3SLC6A2, SLC6A4, HTR1A
38-hydroxy-2-(di-n-propylamino)tetralin459.3SLC6A4, HTR2A, HTR1A
4m-chlorophenylpiperazine459.2HTR2A, SLC6A4, HTR1A
5mcpp459.1HTR2A, HTR1A, SLC6A4
6selective serotonin reuptake inhibitors519.1HTR2A, HTR1A, SLC6A4
7duloxetine45 51 29 1112.0SLC6A2, HTR2A, SLC6A4
8bufotenine45 29 1111.0HTR1A, MAOA, HTR2A
95-hydroxytryptophan458.9HTR2A, HTR1A, SLC6A4, TPH1
10fenfluramine45 29 1110.9SLC6A4, HTR2A, TPH1, HTR1A
11naratriptan45 29 1110.9HTR1A, MAOA, HTR2A
12phentermine45 119.9SLC6A2, SLC6A4, MAOA
13trimipramine45 51 1110.9HTR2A, HTR1A, SLC6A2, SLC6A4
14nefazodone45 51 1110.9HTR1A, HTR2A, SLC6A2, SLC6A4
15escitalopram45 51 24 1111.9HTR1A, SLC6A2, SLC6A4, HTR2A
16venlafaxine45 51 24 1111.8SLC6A2, SLC6A4, HTR1A, HTR2A
17doxepin45 29 51 1111.8SLC6A2, HTR1A, HTR2A, SLC6A4
18carbon-11458.8SLC6A4, HTR1A, MAOA, TSPO
19nortriptyline51 45 29 1111.8SLC6A2, SLC6A4, HTR1A, HTR2A
20benzodiazepines458.8TSPO, CCKBR, MAOA
21d amphetamine458.7SLC6A4, SLC6A2, MAOA, TSPO
22p-chloroamphetamine458.7SLC6A2, SLC6A4, MAOA, HTR1A
23pseudoephedrine45 24 1110.7SLC6A2, SLC6A4, MAOA
24sertraline45 29 51 24 1112.7HTR1A, SLC6A2, SLC6A4, MAOA
25raclopride45 299.7HTR2A, CCKBR, HTR1A
26homovanillic acid45 249.6TPH1, MAOA, SLC6A2, SLC6A4
275-hydroxyindoleacetic acid45 249.6TPH1, MAOA, SLC6A4, SLC6A2
28mptp458.6TSPO, MAOA, SLC6A2, SLC6A4
29minaprine45 119.6SLC6A4, MAOA, HTR2A
30methamphetamine45 51 1110.6MAOA, TPH1, SLC6A2, SLC6A4
31Serotonin248.5HTR1A, MAOA, SLC6A4, HTR2A
32mdma458.3TPH1, HTR1A, MAOA, SLC6A4, SLC6A2
33gaba458.2SLC6A2, MAOA, TPH1, TSPO, SLC6A4
34amphetamine45 51 1110.1CCKBR, MAOA, SLC6A4, TPH1, SLC6A2
35mianserin45 29 1110.1SLC6A2, HTR1A, MAOA, HTR2A, SLC6A4
36amitriptyline45 29 51 1111.1SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A
37desipramine45 51 1110.1SLC6A2, HTR2A, HTR1A, MAOA, SLC6A4
38imipramine45 29 51 24 1112.1HTR2A, SLC6A2, SLC6A4, MAOA, HTR1A
39haloperidol45 51 29 3 1112.1TSPO, CCKBR, HTR2A, HTR1A, SLC6A4, SLC6A2
40nicotine45 29 51 1110.8TPH1, TSPO, MAOA, CCKBR, SLC6A2, SLC6A4
41nmda45 298.8MAOA, SLC6A4, HTR1A, CCKBR, TSPO
42clomipramine45 51 119.8TSPO, HTR2A, HTR1A, MAOA, SLC6A4, SLC6A2
43paroxetine45 51 29 1110.7SLC6A2, HTR2A, HTR1A, SLC6A4, MAOA, TPH1
44maoa457.7SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A, TPH1
45fluoxetine45 51 29 1110.7HTR2A, TPH1, SLC6A2, MAOA, HTR1A, SLC6A4
46citalopram45 51 24 1110.7TPH1, HTR1A, MAOA, SLC6A4, SLC6A2, HTR2A
475-hydroxytryptamine457.4TPH1, TSPO, HTR2A, HTR1A, MAOA, SLC6A2
48fluvoxamine45 51 119.4TPH1, TSPO, HTR1A, MAOA, SLC6A4, SLC6A2
49norepinephrine45 24 119.3SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A, TSPO
50dopamine45 29 24 119.8CCKBR, TSPO, SLC6A2, SLC6A4, MAOA, TPH1

GO Terms for genes affiliated with Anxiety Disorder

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Sources:
16Gene Ontology
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Cellular components related to Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.1SLC6A2, SLC6A4, TPH1
2integral component of plasma membraneGO:0058877.7SLC6A2, SLC6A4, HTR1A, HTR2A, CCKBR

Biological processes related to Anxiety Disorder according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:0468839.7HTR1A, HTR2A
2monoamine transportGO:0158449.7SLC6A2, SLC6A4
3vasoconstrictionGO:0423109.6SLC6A4, HTR1A
4serotonin receptor signaling pathwayGO:0072109.6HTR1A, HTR2A
5regulation of behaviorGO:0507959.6HTR2A, HTR1A
6circadian rhythmGO:0076239.4TPH1, SLC6A4
7cell proliferationGO:0082839.2HTR1A, CCKBR, TSPO
8memoryGO:0076139.0SLC6A4, HTR2A
9positive regulation of cell proliferationGO:0082849.0HTR1A, HTR2A, CCKBR
10response to drugGO:0424938.8SLC6A2, SLC6A4, HTR2A, TSPO
11synaptic transmissionGO:0072688.4TSPO, HTR2A, MAOA, SLC6A2

Molecular functions related to Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.5HTR1A, HTR2A
2monoamine transmembrane transporter activityGO:0085049.2SLC6A2, SLC6A4

Products for genes affiliated with Anxiety Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Anxiety Disorder

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet