MCID: ANX002
MIFTS: 69

Anxiety Disorder malady

Mental diseases, Neuronal diseases categories
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Summaries for Anxiety Disorder

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MedlinePlus:33 Fear and anxiety are part of life. you may feel anxious before you take a test or walk down a dark street. this kind of anxiety is useful - it can make you more alert or careful. it usually ends soon after you are out of the situation that caused it. but for millions of people in the united states, the anxiety does not go away, and gets worse over time. they may have chest pains or nightmares. they may even be afraid to leave home. these people have anxiety disorders. types include panic disorder obsessive-compulsive disorder post-traumatic stress disorder phobias generalized anxiety disorder treatment can involve medicines, therapy or both. nih: national institute of mental health

MalaCards based summary: Anxiety Disorder, also known as anxiety disorders, is related to generalized anxiety disorder and panic disorder. An important gene associated with Anxiety Disorder is TSPO (translocator protein (18kDa)), and among its related pathways are Venlafaxine Pathway, Pharmacokinetics and Monoamine GPCRs. The drugs chlordiazepoxide and chlordiazepoxide hydrochloride and the compounds p-chlorophenylalanine and milnacipran have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are nervous system and cardiovascular system.

Disease Ontology:8 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:65 Anxiety disorders are a group of mental disorders characterized by feelings of anxiety and fear, where... more...

Aliases & Classifications for Anxiety Disorder

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 62UMLS, 33MedlinePlus, 39NCIt, 57SNOMED-CT, 34MeSH, 25ICD10
See all sources

Anxiety Disorder, Aliases & Descriptions:

Name: Anxiety Disorder 8 22 10
Anxiety Disorders 44 62
Anxiety Neurosis 62
 
Anxiety State 8
Anxiety 33


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:2030
NCIt39 C2878
MeSH34 D001008
ICD1025 F41.8, F41.9

Related Diseases for Anxiety Disorder

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Diseases related to Anxiety Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1generalized anxiety disorder32.2TSPO, SLC6A4, HTR1A
2panic disorder31.1TSPO, HTR1A, SLC6A4, CCKBR
3substance abuse31.1SLC6A4
4bipolar disorder31.0SLC6A4, HTR2A
5oppositional defiant disorder31.0SLC6A2
6social phobia30.9SLC6A4, MAOA, HTR1A
7personality disorder30.7MAOA, TPH1, SLC6A4
8neuroleptic malignant syndrome30.5HTR1A
9irritable bowel syndrome30.5TPH1, SLC6A4
10agoraphobia30.4MAOA, HTR1A, CCKBR, SLC6A2
11dysthymic disorder30.4HTR2A, MAOA
12eating disorder30.3HTR1A, SLC6A4, HTR2A
13alcohol dependence30.2HTR2A, SLC6A4, MAOA
14substance dependence30.2TPH1, SLC6A4
15drug dependence30.1MAOA, SLC6A4
16antisocial personality disorder30.1HTR2A, MAOA, SLC6A4
17borderline personality disorder30.1SLC6A4, MAOA, TPH1
18schizoaffective disorder30.0HTR2A, SLC6A4
19conduct disorder29.9MAOA, SLC6A4
20fibromyalgia29.9SLC6A4, HTR2A, TSPO
21attention deficit hyperactivity disorder29.9HTR2A, MAOA, SLC6A4, SLC6A2
22chronic fatigue syndrome29.8SLC6A4, HTR1A, MAOA
23bulimia nervosa29.7HTR2A, MAOA, SLC6A4
24obsessive-compulsive disorder29.7SLC6A4, SLC6A2, MAOA, HTR1A, HTR2A, TSPO
25dementia29.7MAOA, HTR2A, TSPO, HTR1A
26mood disorder29.4HTR2A, TPH1, SLC6A4, HTR1A, MAOA, SLC6A2
27anorexia nervosa29.2TPH1, SLC6A2, SLC6A4, HTR2A, HTR1A, MAOA
28psychotic disorder29.1TPH1, HTR2A, HTR1A, MAOA, SLC6A4
29migraine29.1MAOA, HTR2A, SLC6A4, TPH1, HTR1A
30schizophrenia28.6CCKBR, HTR1A, MAOA, SLC6A2, HTR2A, TPH1
31parkinson's disease28.3MAOA, SLC6A4, SLC6A2, HTR2A, TPH1, TSPO
32separation anxiety disorder10.9
33major depressive disorder10.7
34blindness10.7
35hypochondriasis10.4
36specific phobia10.4
37alcoholic psychosis10.4SLC6A4
38bipolar i disorder10.3
39phobic disorder10.3
40amnestic disorder10.3HTR1A, TSPO
41melancholia10.2MAOA
42post-traumatic stress disorder10.2
43avoidant personality disorder10.2
44hypermobility syndrome10.2
45nicotine dependence10.2
46mutism10.2
47endogenous depression10.2HTR1A, SLC6A4
48premature ejaculation10.2SLC6A4, HTR1A
49temporal lobe epilepsy10.2TSPO, HTR1A
50mitral valve prolapse10.2

Graphical network of the top 20 diseases related to Anxiety Disorder:



Diseases related to anxiety disorder

Symptoms for Anxiety Disorder

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Genetic Tests for Anxiety Disorder

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Genetic tests related to Anxiety Disorder:

id Genetic test Affiliating Genes
1 Anxiety22

Anatomical Context for Anxiety Disorder

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MalaCards organs/tissues related to Anxiety Disorder:

32
Heart, Testes, Brain, Cortex, Amygdala, Eye, Prefrontal cortex, Cingulate cortex, Thyroid, Liver, Lung, Ovary, Prostate, Monocytes, Fetal brain, Temporal lobe, Hypothalamus, Pituitary

Animal Models for Anxiety Disorder or affiliated genes

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MGI Mouse Phenotypes related to Anxiety Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8SLC6A2, SLC6A4, MAOA, HTR1A, CCKBR
2MP:00053857.3TPH1, CCKBR, HTR1A, MAOA, SLC6A4, SLC6A2
3MP:00053767.1TPH1, CCKBR, HTR1A, MAOA, SLC6A4, SLC6A2
4MP:00053866.7SLC6A2, TPH1, CCKBR, HTR2A, HTR1A, MAOA

Publications for Anxiety Disorder

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Articles related to Anxiety Disorder:

(show top 50)    (show all 1099)
idTitleAuthorsYear
1
Emotional reasoning and anxiety sensitivity: associations with social anxiety disorder in childhood. (24120086)
2014
2
Clinical experiences in conducting empirically supported treatments for generalized anxiety disorder. (24411110)
2014
3
Comorbidity of oppositional defiant disorder and anxiety disorders in preschoolers. (24444726)
2014
4
Comorbid social withdrawal (hikikomori) in outpatients with social anxiety disorder: clinical characteristics and treatment response in a case series. (21997765)
2013
5
Adult separation anxiety disorder in DSM-5. (23673209)
2013
6
Comorbidity of social anxiety disorder and antisocial personality disorder in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). (24384071)
2013
7
Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety disorder. (22130178)
2013
8
Social anxiety and social anxiety disorder. (23537485)
2013
9
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
10
Is adolescent generalized anxiety disorder a magnet for negative parental interpersonal behaviors? (23390021)
2013
11
The effect of escitalopram on metabolic parameters in patients with major depressive disorder, generalised anxiety disorder, and panic disorder: a prospective 6-month follow-up study. (23642988)
2013
12
Evaluation of the proposed social anxiety disorder specifier change for DSM-5 in a treatment-seeking sample of anxious youth. (23494954)
2013
13
Commitment to a purpose in life: An antidote to the suffering by individuals with social anxiety disorder. (23795592)
2013
14
Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. (22116310)
2012
15
Pregabalin versus SSRIs and SNRIs in benzodiazepine-refractory outpatients with generalized anxiety disorder: a post hoc cost-effectiveness analysis in usual medical practice in Spain. (22745564)
2012
16
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
17
Panic-focused psychodynamic psychotherapy in a woman with panic disorder and generalized anxiety disorder. (23030215)
2012
18
Are children with "pure" generalized anxiety disorder impaired? A comparison with comorbid and healthy children. (22963176)
2012
19
Generalized anxiety disorder and the proposed associated symptoms criterion change for DSM-5 in a treatment-seeking sample of anxious youth. (22952043)
2012
20
A parent-child interactional model of social anxiety disorder in youth. (22116625)
2012
21
Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder. (22320999)
2012
22
Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder. (21872345)
2011
23
Association between generalized anxiety disorder and asthma morbidity. (21715294)
2011
24
Cognitive-Behavioral Therapy for Immigrants Presenting With Social Anxiety Disorder: Two Case Studies. (22844232)
2011
25
Statistical alchemy for drug treatment of generalized anxiety disorder: a commentary on the meta-analysis by Baldwin et al. [BMJ 2011;342:d1199]. (21654185)
2011
26
Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. (20439149)
2010
27
A multicenter, placebo-controlled, double-blind, randomized study of efficacy and safety of ocinaplon (DOV 273,547) in generalized anxiety disorder. (20041911)
2010
28
Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. (20123913)
2010
29
Management of generalized anxiety disorder in primary care: identifying the challenges and unmet needs. (20694114)
2010
30
Understanding behavior: generalized anxiety disorder. (20180208)
2009
31
Pharmacotherapy for social anxiety disorder: an update. (19728573)
2009
32
Panic disorder and social anxiety disorder subtypes in a caffeine challenge test. (19698996)
2009
33
How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale. (19273493)
2009
34
Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: a randomized, controlled trial. (19570931)
2009
35
Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence. (18399707)
2008
36
A preliminary study of fMRI-guided rTMS in the treatment of generalized anxiety disorder. (18572984)
2008
37
Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial. (18344738)
2008
38
Anxiety disorder comobidity in Bipolar I Disorder: relationship to depression severity and treatment outcome. (15786484)
2005
39
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
40
New pharmacological treatment approaches for anxiety disorders. (16594270)
2005
41
Separation anxiety disorder. (15768687)
2005
42
The Nottingham Study of Neurotic Disorder: predictors of 12-year outcome of dysthymic, panic and generalized anxiety disorder. (15724870)
2004
43
Separation anxiety disorder: planning treatment. (10878189)
2000
44
No association between anxiety disorders and catechol-O-methyltransferase polymorphism. (9754693)
1998
45
Two cases of essential myoclonus, epilepsy, mental retardation and anxiety disorders. (9339874)
1997
46
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
47
A phase II multicenter dose-finding, efficacy and safety trial of ipsapirone in outpatients with generalized anxiety disorder. (7915845)
1994
48
5-HT1A receptor sensitivity in depression and anxiety disorders: molecular mechanisms of neuroadaption. (1498813)
1992
49
5-HT1A receptor responsivity in anxiety disorders and depression. (1763190)
1991
50
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988

Variations for Anxiety Disorder

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Expression for genes affiliated with Anxiety Disorder

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Expression patterns in normal tissues for genes affiliated with Anxiety Disorder

Search GEO for disease gene expression data for Anxiety Disorder.

Pathways for genes affiliated with Anxiety Disorder

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Pathways related to Anxiety Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SLC6A2, SLC6A4
2
Show member pathways
9.5HTR1A, HTR2A
3
Show member pathways
9.2MAOA, TPH1
4
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.2MAOA, TPH1
5
Show member pathways
catecholamine biosynthesis37
9.2MAOA, TPH1
6
Show member pathways
Serotonin Transporter Activity37
8.7MAOA, SLC6A4, SLC6A2
7
Show member pathways
8.6TSPO, CCKBR, HTR2A, HTR1A
8
Show member pathways
7.7SLC6A4, MAOA, HTR1A, HTR2A, TPH1
97.7SLC6A4, MAOA, HTR1A, HTR2A, TPH1
107.7TPH1, HTR2A, HTR1A, MAOA, SLC6A4

Compounds for genes affiliated with Anxiety Disorder

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Anxiety Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1p-chlorophenylalanine449.5HTR1A, SLC6A4, TPH1
2milnacipran44 50 1111.3SLC6A2, SLC6A4, HTR1A
38-hydroxy-2-(di-n-propylamino)tetralin449.3SLC6A4, HTR2A, HTR1A
4m-chlorophenylpiperazine449.2HTR2A, SLC6A4, HTR1A
5mcpp449.1HTR2A, HTR1A, SLC6A4
6selective serotonin reuptake inhibitors509.1HTR2A, HTR1A, SLC6A4
7duloxetine44 50 28 1112.0SLC6A2, HTR2A, SLC6A4
8bufotenine44 28 1111.0HTR1A, MAOA, HTR2A
95-hydroxytryptophan448.9HTR2A, HTR1A, SLC6A4, TPH1
10fenfluramine44 28 1110.9SLC6A4, HTR2A, TPH1, HTR1A
11naratriptan44 28 1110.9HTR1A, MAOA, HTR2A
12phentermine44 119.9SLC6A2, SLC6A4, MAOA
13trimipramine44 50 1110.9HTR2A, HTR1A, SLC6A2, SLC6A4
14nefazodone44 50 1110.9HTR1A, HTR2A, SLC6A2, SLC6A4
15escitalopram44 50 24 1111.9HTR1A, SLC6A2, SLC6A4, HTR2A
16venlafaxine44 50 24 1111.8SLC6A2, SLC6A4, HTR1A, HTR2A
17doxepin44 28 50 1111.8SLC6A2, HTR1A, HTR2A, SLC6A4
18carbon-11448.8SLC6A4, HTR1A, MAOA, TSPO
19nortriptyline50 44 28 1111.8SLC6A2, SLC6A4, HTR1A, HTR2A
20benzodiazepines448.8TSPO, CCKBR, MAOA
21d amphetamine448.7SLC6A4, SLC6A2, MAOA, TSPO
22p-chloroamphetamine448.7SLC6A2, SLC6A4, MAOA, HTR1A
23pseudoephedrine44 24 1110.7SLC6A2, SLC6A4, MAOA
24sertraline44 28 50 24 1112.7HTR1A, SLC6A2, SLC6A4, MAOA
25raclopride44 289.7HTR2A, CCKBR, HTR1A
26homovanillic acid44 249.6TPH1, MAOA, SLC6A2, SLC6A4
275-hydroxyindoleacetic acid44 249.6TPH1, MAOA, SLC6A4, SLC6A2
28mptp448.6TSPO, MAOA, SLC6A2, SLC6A4
29minaprine44 119.6SLC6A4, MAOA, HTR2A
30methamphetamine44 50 1110.6MAOA, TPH1, SLC6A2, SLC6A4
31Serotonin248.5HTR1A, MAOA, SLC6A4, HTR2A
32mdma448.3TPH1, HTR1A, MAOA, SLC6A4, SLC6A2
33gaba448.2SLC6A2, MAOA, TPH1, TSPO, SLC6A4
34amphetamine44 50 1110.1CCKBR, MAOA, SLC6A4, TPH1, SLC6A2
35mianserin44 28 1110.1SLC6A2, HTR1A, MAOA, HTR2A, SLC6A4
36amitriptyline44 28 50 1111.1SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A
37desipramine44 50 1110.1SLC6A2, HTR2A, HTR1A, MAOA, SLC6A4
38imipramine44 28 50 24 1112.1HTR2A, SLC6A2, SLC6A4, MAOA, HTR1A
39haloperidol44 50 28 2 1112.1TSPO, CCKBR, HTR2A, HTR1A, SLC6A4, SLC6A2
40nicotine44 28 50 1110.8TPH1, TSPO, MAOA, CCKBR, SLC6A2, SLC6A4
41nmda44 288.8MAOA, SLC6A4, HTR1A, CCKBR, TSPO
42clomipramine44 50 119.8TSPO, HTR2A, HTR1A, MAOA, SLC6A4, SLC6A2
43paroxetine44 50 28 1110.7SLC6A2, HTR2A, HTR1A, SLC6A4, MAOA, TPH1
44maoa447.7SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A, TPH1
45fluoxetine44 50 28 1110.7HTR2A, TPH1, SLC6A2, MAOA, HTR1A, SLC6A4
46citalopram44 50 24 1110.7TPH1, HTR1A, MAOA, SLC6A4, SLC6A2, HTR2A
475-hydroxytryptamine447.4TPH1, TSPO, HTR2A, HTR1A, MAOA, SLC6A2
48fluvoxamine44 50 119.4TPH1, TSPO, HTR1A, MAOA, SLC6A4, SLC6A2
49norepinephrine44 24 119.3SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A, TSPO
50dopamine44 28 24 119.8CCKBR, TSPO, SLC6A2, SLC6A4, MAOA, TPH1

GO Terms for genes affiliated with Anxiety Disorder

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Cellular components related to Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:0430059.1SLC6A2, SLC6A4, TPH1
2integral component of plasma membraneGO:0058877.7SLC6A2, SLC6A4, HTR1A, HTR2A, CCKBR

Biological processes related to Anxiety Disorder according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:0468839.7HTR1A, HTR2A
2monoamine transportGO:0158449.7SLC6A2, SLC6A4
3vasoconstrictionGO:0423109.6SLC6A4, HTR1A
4serotonin receptor signaling pathwayGO:0072109.6HTR1A, HTR2A
5regulation of behaviorGO:0507959.6HTR2A, HTR1A
6circadian rhythmGO:0076239.4TPH1, SLC6A4
7cell proliferationGO:0082839.2HTR1A, CCKBR, TSPO
8memoryGO:0076139.0SLC6A4, HTR2A
9positive regulation of cell proliferationGO:0082849.0HTR1A, HTR2A, CCKBR
10response to drugGO:0424938.8SLC6A2, SLC6A4, HTR2A, TSPO
11synaptic transmissionGO:0072688.4TSPO, HTR2A, MAOA, SLC6A2

Molecular functions related to Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.5HTR1A, HTR2A
2monoamine transmembrane transporter activityGO:0085049.2SLC6A2, SLC6A4

Products for genes affiliated with Anxiety Disorder

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  • Antibodies
  • Proteins
  • Lysates

Sources for Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet