Anxiety Disorder malady

MedlinePlus: Fear and anxiety are part of life. you may feel anxious before you take a test or walk down a dark street. this kind of anxiety is useful - it can make you more alert or careful. it usually ends soon after you are out of the situation that caused it. but for millions of people in the united states, the anxiety does not go away, and gets worse over time. they may have chest pains or nightmares. they may even be afraid to leave home. these people have anxiety disorders. types include panic disorder obsessive-compulsive disorder post-traumatic stress disorder phobias generalized anxiety disorder treatment can involve medicines, therapy or both. nih: national institute of mental health²³

MalaCards: Anxiety Disorder, also known as anxiety disorders, is related to generalized anxiety disorder and panic disorder. An important gene associated with Anxiety Disorder is TSPO (translocator protein (18kDa)), and among its related pathways are Tyrosine metabolism p.1 (dopamine) and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The drugs clorazepate and chlordiazepoxide and the compounds mianserin and yohimbine have been mentioned in the context of this disorder. Affiliated tissues include brain, monocytes and amygdala, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Disease Ontology: A cognitive disorder that involves an excessive, irrational dread of everyday situations.⁶

Wikipedia: Anxiety disorder is a blanket term covering several different forms of a type of common psychiatric...⁴⁴ more...

Aliases & Descriptions:

anxiety disorder 6 anxiety disorders 32 43 anxiety neurosis (finding) 43

anxiety disease 8 anxiety state 6 anxiety 23

Diseases related to anxiety disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 336)

id	Related Disease	Score	Top Affiliating Genes
1	generalized anxiety disorder	35.4	HTR1A, TSPO, SLC6A4
2	panic disorder	32.3	CCK, COMT
3	separation anxiety disorder	32.3	DRD4, SLC6A3
4	social phobia	31.1	MAOA, HTR1A, HTR3A, DRD2, COMT, OXT
5	schizophrenia	30.8	MAOA, HTR2A, DRD2, COMT, GAD1
6	anxiety-related personality traits	30.2	BDNF, COMT, SLC6A4
7	bulimia nervosa	29.8	CCK, HTR3A, COMT, SLC6A4
8	phobia	29.2	MAOA, CCK, HTR1A, HTR3A, DRD2, PTK7
9	anorexia nervosa	29.1	BDNF, HTR2A
10	narcolepsy	29.0	MAOA, HTR1B, HTR2A, HTR3A, TPH1, DRD2
11	somatoform disorder	29.0	COMT, TTF2, TSPO
12	agoraphobia	28.8	MAOA, CCKBR, HTR1A, PTK7, SLC6A2
13	fragile x syndrome	28.5	BDNF, FMR1, MAOA, SLC6A4
14	neurotic disorder	27.8	BDNF, MAOA, HTR1A, HTR2A, HTR3A, DRD2
15	eating disorder	27.3	CNR1, BDNF, CCK, HTR1A, HTR2A, HTR3A
16	stiff-person syndrome	27.3	TSPO, GAD1, GAD2
17	post-traumatic stress disorder	27.2	CNR1, BDNF, FKBP5, MAOA, DRD2, NR3C1
18	essential tremor	27.1	FMR1, TPH1, CYP2D6, COMT, SLC6A3
19	cushing's syndrome	27.0	NR3C1, NR3C2, CRH
20	insomnia	26.8	HTR1A, HTR2A, HTR2C, HTR3A, CRH, TTF2
21	was-related disorders	26.7	CNR1, BDNF, FMR1, HTR2A, DRD2, CRH
22	atopic dermatitis	26.7	BDNF, HTR1A, HTR2A, NR3C1, TTF2, TACR1
23	alcohol abuse	26.4	HTR1B, HTR2A, DRD2, NR3C1, COMT, PRL
24	dermatitis	26.4	CNR1, BDNF, HTR1A, HTR2A, NR3C1, TTF2
25	alcoholism	26.3	CNR1, MAOA, MAOB, CCKBR, CCK, HTR1A
26	postpartum depression	26.3	BDNF, MAOA, HTR1A, CRH, COMT, OXT
27	chronic pain	26.2	P2RX4, CCK, NR3C1, COMT, TTF2, TACR1
28	tremor	26.1	CNR1, FMR1, CCK, HTR2A, HTR2C, HTR3A
29	adrenal gland hyperfunction	26.1	NR3C1, NR3C2, CRH, PRL
30	mood disorder	26.0	CNR1, BDNF, P2RX7, MAOA, MAOB, HTR1A
31	migraine with aura	25.8	HTR1B, HTR2A, HTR2C, ESR1, DRD2, SLC6A3
32	obsessive-compulsive disorder	25.5	BDNF, MAOA, CCKBR, CCK, HTR1A, HTR1B
33	substance abuse	25.3	CNR1, BDNF, MAOA, MAOB, HTR1A, HTR1B
34	adhd	25.1	CNR1, BDNF, MAOA, MAOB, HTR1A, HTR1B
35	hepatitis c	24.8	CNR1, HTR1A, HSP90AA1, ESR1, TPH2, CYP2D6
36	tourette syndrome	24.8	CNR1, BDNF, MAOA, HTR1A, HTR2A, HTR2C
37	headache	24.8	BDNF, MAOA, HTR1A, HTR1B, HTR2A, HTR2C
38	fibromyalgia	24.7	BDNF, FKBP5, MAOA, MAOB, HTR2A, HTR3A
39	irritable bowel syndrome	24.6	P2RX7, CCK, HTR1A, HTR2A, HTR3A, TPH1
40	autism spectrum disorder	24.5	CNR1, BDNF, MAOA, MAOB, CCK, HTR1B
41	parkinson's disease	24.4	CNR1, BDNF, FMR1, MAOA, MAOB, CCKBR
42	pheochromocytoma	23.8	MAOB, HSP90AA1, ESR1, DRD2, CYP2D6, NTRK3
43	blindness	23.8	CNR1, MAOA, MAOB, CCKBR, CCK, HTR1A
44	ovarian cancer	23.6	HTR3A, HSP90AA1, ESR1, DRD2, CYP3A4, NR3C1
45	alcohol dependence	23.6	CNR1, BDNF, MAOA, MAOB, CCKBR, CCK
46	twinning	23.6	BDNF, FMR1, MAOA, DRD2, DRD4, CYP2D6
47	seizures	23.5	CNR1, BDNF, FMR1, MAOA, MAOB, HTR1A
48	major depressive disorder	22.4	CNR1, BDNF, P2RX7, FKBP5, MAOA, MAOB
49	asthma	21.7	CNR1, BDNF, P2RX7, FMR1, FKBP5, HTR2A
50	hepatitis	20.8	CNR1, BDNF, P2RX7, MAOA, MAOB, CCKBR

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amobarbital, amobarbital na pwdr [va product], amobarbital sodium, bromodiphenhydramine, bromodiphenhydramine hydrochloride, buspirone, buspirone hydrochloride, chlordiazepoxide, chlordiazepoxide hydrochloride, chlormezanone, chlorpromazine, chlorpromazine hydrochloride, clorazepate, clorazepate dipotassium, diphenhydramine, diphenhydramine citrate, diphenhydramine hydrochloride, doxepin, doxepin hydrochloride, halazepam, hydroxyzine, hydroxyzine hydrochloride, hydroxyzine pamoate, hypericum perforatum (st. john's wort), kava, kava extract, lorazepam, meprobamate, methotrimeprazine, midazolam, midazolam hydrochloride, nortriptyline, nortriptyline hydrochloride, oxazepam, prazepam, prochlorperazine, prochlorperazine edisylate, prochlorperazine maleate

MalaCards organs/tissues related to anxiety disorder:

²²

MGI Mouse Phenotypes related to anxiety disorder:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.6	GAD1, SLC6A1, SLC6A3, DRD2, TPH2, BDNF
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	GAD2, GAL, CRHR1, HTR2A, HTR1B, FMR1
3	respiratory system phenotype	MP:0005388	9.2	GAD2, GAD1, CRHR1, CRH, PTK7, DRD2
4	no phenotypic analysis	MP:0003012	8.9	RGS2, DRD2, TPH2, ESR1, BDNF, CNR1
5	reproductive system phenotype	MP:0005389	8.6	SLC6A3, GABBR1, GAL, GAD2, PRL, OXT
6	adipose tissue phenotype	MP:0005375	8.2	GABBR1, NPY, CRHR2, NR3C1, DRD2, TPH2
7	skeleton phenotype	MP:0005390	7.9	GAD1, TACR1, NR3C1, PTK7, DRD2, ESR1
8	normal phenotype	MP:0002873	7.7	SLC6A3, SLC6A1, SLC6A4, RGS2, GAD1, NPY
9	renal/urinary system phenotype	MP:0005367	7.7	NR3C1, NR3C2, COMT, OXT, NPY, RGS2
10	integument phenotype	MP:0010771	6.5	CRH, TACR1, OXT, DBI, PRL, SLC6A2
11	cardiovascular system phenotype	MP:0005385	6.4	NR3C1, NR3C2, CRHR1, CRHR2, COMT, TACR1
12	mortality/aging	MP:0010768	5.7	NR3C2, CRHR1, OXT, DBI, SLC6A3, SLC6A4
13	nervous system phenotype	MP:0003631	5.3	DRD2, GABBR1, GAD1, GAL, GAD2, SLC6A4
14	growth/size phenotype	MP:0005378	4.9	NPY, DBI, PLXNA2, CRH, NR3C2, SLC6A2
15	homeostasis/metabolism phenotype	MP:0005376	4.7	CNR1, BDNF, P2RX4, FKBP5, MAOA, MAOB
16	behavior/neurological phenotype	MP:0005386	3.1	CNR1, TPH1, TPH2, DRD2, DRD4, NTRK3

Articles related to anxiety disorder:

(show top 50)    (show all 101)

id	Title	Authors	Year	Affiliating Genes
1	Lifetime prevalence of mood and anxiety disorders in fragile X premutation carriers. (20816038)	Bourgeois J.A.... Hagerman R.J.	2011	FMR1
2	NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-expos ed adults. (20037921)	Amstadter A.B.... Gelernter J.	2010	NPY
3	Association of DRD4 polymorphism with severity of opp ositional defiant disorder, separation anxiety disorder and repetitive behavior s in children with autism spectrum disorder. (20731709)	Gadow K.D.... Hatchwell E.	2010	SLC6A3, DRD4
4	An association analysis of circadian genes in anxiety disorders. (20122683)	SipilAo T.... Hovatta I.	2010	DRD2
5	Multicenter, randomized, double-blind, active compara tor and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder. (20455246)	Coric V.... Stock E.G.	2010	PLXNA2
6	A complex chromosome 7q rearrangement identified in a patient with mental retardation, anxiety disorder, and autistic features. (20082467)	Dauwerse J.G.... Hilhorst-Hofstee Y.	2010	CPED1
7	The serotonin-1A receptor in anxiety disorders. (19423077)	Akimova E.... Kasper S.	2009	HTR1A
8	Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. (19370765)	MuiA+os-Gimeno M.... Espinosa-Parrilla Y.	2009	NTRK3
9	Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder. (19125211)	Furmark T.... Fredrikson M.	2009	SLC6A4, TPH2
10	Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders. (19229853)	Unschuld P.G.... Binder E.B.	2009	GAD2, MYO3A
11	Translocator protein ligands as promising therapeutic tools for anxiety disorders. (19548867)	Taliani S.... Martini C.	2009	TSPO
12	The role of pharmacogenetics in the treatment of depr ession and anxiety disorders. (19738481)	Schosser A.... Kasper S.	2009	MAOA, TPH1
13	Dopamine transporters, D2 receptors, and dopamine release in generalized social anxiety disorder. (19180583)	Schneier F.R.... Laruelle M.	2009	DRD2, SLC6A3
14	The endocannabinoid system and the treatment of mood and anxiety disorders. (19839936)	Hill M.N.... Gorzalka B.B.	2009	CNR1
15	Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence. (18399707)	Pae C.U.... Masand P.S.	2008	HTR2C, HTR1A
16	Blushing propensity in social anxiety disorder: influence of serotonin transporter gene variation. (18629430)	Domschke K.... Gerlach A.L.	2008	SLC6A4
17	Increased serotonin and dopamine transporter binding in psychotropic medication-naive patients with generalized social anxiety disorder shown by 123I-beta-(4-iodophenyl)-tropane SPECT. (18413401)	van der Wee N.J.... Westenberg H.G.	2008	SLC6A3
18	Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits. (19088493)	Frustaci A.... Boccia S.	2008	BDNF
19	Oxytocin levels in social anxiety disorder. (18801109)	Hoge E.A.... Simon N.M.	2008	OXT
20	Serotonin transporter polymorphism (5-HTTLPR) and citalopram effectiveness and side effects in children with depression and/or anxiety disorders. (18315446)	Kronenberg S.... Weizman A.	2007	SLC6A4
21	Absence of the Arg441His polymorphism in the tryptophan hydroxylase 2 gene in adults with anxiety disorders and depression. (17192895)	Henningsson S.... Westberg L.	2007	TPH2
22	Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa. (16899354)	Lochner C.... Stein D.J.	2007	HTR2A
23	Protein-source tryptophan as an efficacious treatment for social anxiety disorder: a pilot study. (18066139)	Hudson C.... Mackenzie J.	2007	WRB
24	Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks. (16904689)	Thoeringer C.K.... Keck M.E.	2007	DBI
25	Managing depressive and anxiety disorders with escita lopram. (16503815)	Thase M.E.	2006	SLC6A4
26	Azapirones for generalized anxiety disorder. (16856115)	Chessick C.A.... dos Santos Souza J.J.	2006	HTR1A
27	Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus. (16532386)	Kaabi B.... Elston R.C.	2006	PAND3
28	Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. (16594259)	Linthorst A.C.	2005	CRH
29	Estrogen receptor alpha gene polymorphisms and anxiety disorder in an elderly population. (15940291)	Tiemeier H.... Uitterlinden A.G.	2005	ESR1
30	Social anxiety disorder : current treatment recommendations. (15907150)	Muller J.E.... Stein D.J.	2005	MAOA
31	Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. (15722951)	You J.S.... Zhang H.G.	2005	TPH1, SLC6A4
32	Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. (15450911)	Samochowiec J.... Kucharska-Mazur J.	2004	COMT, MAOA, SLC6A4
33	Early-Life Adversity, CRF Dysregulation, and Vulnerability to Mood and Anxiety Disorders. (17065965)	Nemeroff C.B.	2004	CRH
34	A search for psychobiological determinants of anxiety disorders (16529167)	Hajduk A.	2004	COMT, MAOA
35	SPECT imaging of serotonin transporter binding in patients with generalized anxiety disorder. (15538601)	Maron E.... Shlik J.	2004	SLC6A4
36	Early-Life Adversity, CRF Dysregulation, and Vulnerability to Mood and Anxiety Disorders. (15278013)	Nemeroff CB C.B.	2004	CRH
37	Pharmacotherapy of social anxiety disorder. (11801236)	Blanco C.... Liebowitz M.R.	2002	MAOA
38	Glutamate-hypothalamic-pituitary-adrenal axis interactions: implications for mood and anxiety disorders. (15573019)	Mathew S.J.... Gorman J.M.	2001	CRH
39	Neuroendocrine responses to psychological stress in adolescents with anxiety disorder. (10940763)	Gerra G.... Brambilla F.	2000	PRL
40	Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse. (11256582)	Weizman A.... Weizman R.	2000	SLC6A4
41	The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. (11104852)	Fehr C.... Dahmen N.	2000	HTR1B
42	Benzodiazepine-induced chemotaxis is impaired in monocytes from patients with generalized anxiety disorder. (10101731)	Sacerdote P.... Ferrarese C.	1999	TSPO
43	Association between anxiety disorders and a functional polymorphism in the serotonin transporter gene. (9858044)	Ohara K.... Ohara K.	1998	SLC6A4
44	Brain mechanisms of social anxiety disorder. (9811424)	Nutt D.J.... Malizia A.L.	1998	CCK
45	An open trial of nefazodone in adult patients with ge neralized anxiety disorder. (8993090)	Hedges D.W.... Rust C.	1996	HTR2A
46	Plasma neuropeptide Y in anxiety disorders: findings in panic disorder and social phobia. (8930023)	Stein M.B.... Asmundson G.J.	1996	NPY
47	Efficacy trial of the 5-HT2 antagonist MDL 11,939 in patients with generalized anxiety disorder. (7714223)	Sramek J.J.... Cutler N.R.	1995	HTR2A
48	Benzodiazepine receptor function in anxiety disorders. (7653322)	Malizia A.L.... Nutt D.J.	1995	TSPO
49	The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies. (8491091)	Owens M.J.... Nemeroff C.B.	1993	CRH
50	5-HT1A receptor responsivity in anxiety disorders and depression. (1763190)	Lesch K.P.	1991	HTR1A

Genes related to anxiety disorder according to GeneCards:

(show top 50)    (show all 53)

id	Symbol	Description	Score	GeneCards Section Context
1	TSPO	translocator protein (18kDa)	11.0	Publications
2	CCKBR	cholecystokinin B receptor	11.0	Publications
3	HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	11.0	Publications
4	TPH1	tryptophan hydroxylase 1	11.0	Publications
5	SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	11.0	Publications
6	MAOA	monoamine oxidase A	11.0	Publications
7	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
8	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
9	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
10	HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	11.0	Publications
11	NPY	neuropeptide Y	11.0	Publications
12	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
13	RGS2	regulator of G-protein signaling 2, 24kDa	11.0	Publications
14	CRH	corticotropin releasing hormone	11.0	Publications
15	TPH2	tryptophan hydroxylase 2	11.0	Publications
16	COMT	catechol-O-methyltransferase	11.0	Publications
17	GAL	galanin prepropeptide	11.0
18	CNR1	cannabinoid receptor 1 (brain)	11.0	Publications
19	CCK	cholecystokinin	11.0	Publications
20	TTF2	transcription termination factor, RNA polymerase II	11.0
21	MAOB	monoamine oxidase B	11.0	Publications
22	DRD4	dopamine receptor D4	11.0	Publications
23	OXT	oxytocin, prepropeptide	11.0	Publications
24	PTK7	PTK7 protein tyrosine kinase 7	11.0
25	GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	11.0
26	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
27	CRHR2	corticotropin releasing hormone receptor 2	11.0
28	PLXNA2	plexin A2	11.0	Publications
29	CRHR1	corticotropin releasing hormone receptor 1	11.0
30	TACR1	tachykinin receptor 1	11.0
31	NR3C2	nuclear receptor subfamily 3, group C, member 2	11.0
32	DRD2	dopamine receptor D2	11.0	Publications
33	BDNF	brain-derived neurotrophic factor	11.0	Publications
34	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0
35	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0
36	PAND3	panic disorder 3	11.0	Publications
37	WRB	tryptophan rich basic protein	11.0	Publications
38	P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	11.0	Publications
39	DBI	diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)	11.0	Publications
40	SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	11.0	Publications
41	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	11.0	Publications
42	FMR1	fragile X mental retardation 1	11.0	Publications
43	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	11.0	Publications
44	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11.0	Publications
45	P2RX7	purinergic receptor P2X, ligand-gated ion channel, 7	11.0	Publications
46	FKBP5	FK506 binding protein 5	11.0	Publications
47	MYO3A	myosin IIIA	11.0	Publications
48	PRL	prolactin	11.0	Publications
49	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
50	NTRK3	neurotrophic tyrosine kinase, receptor, type 3	11.0	Publications

Pathways related to anxiety disorder according to GeneDecks:

(show all 22)

id	Pathway	Score	Top Affiliating Genes
1	Tyrosine metabolism p.1 (dopamine)41	10.4	COMT, MAOB, MAOA
2	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics34	10.4	CRHR2, CRHR1, CRH
3	Tryptophan metabolism20	10.4	TPH2, TPH1, MAOB, MAOA
4	Tyrosine metabolism p.1 (dopamine)10	10.4	COMT, MAOB, MAOA
5	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.3	MAOA, HTR1A, HTR2A, TPH1, TPH2, SLC6A4
6	Citalopram Pathway, Pharmacokinetics34	10.3	SLC6A4, CYP2D6, CYP3A4
7	Fluoxetine Pathway, Pharmacokinetics34	10.3	CYP3A4, CYP2D6, SLC6A4
8	Selected targets of CREB110	10.2	GAL, GABBR1, CRH, CCK
9	GABA synthesis38	10.2	GAD1, GAD2
10	Benzodiazepine Pathway, Pharmacodynamics34	10.2	TSPO, DBI, SLC6A1
11	Estradiol metabolism41	10.1	COMT, CYP2D6, CYP3A4
12	Estradiol metabolism10	10.1	COMT, CYP2D6, CYP3A4
13	Amine ligand-binding receptors38	10.0	DRD4, DRD2, HTR2C, HTR2A, HTR1B, HTR1A
14	Phenytoin Pathway, Pharmacokinetics34	10.0	COMT, CYP2D6, CYP3A4
15	GABA signaling in brain10	9.9	SLC6A1, GABBR1, GAD1, GAD2
16	G alpha (q) signalling events38	9.9	CCKBR, CCK, TACR1, OXT
17	Drug metabolism - cytochrome P45020	9.9	MAOA, MAOB, CYP3A4, CYP2D6
18	Calcium signaling pathway20	9.8	TACR1, HTR2C, HTR2A, CCKBR, P2RX7, P2RX4
19	CRHR Pathway36	9.5	CRHR2, CRHR1, CRH, BDNF, CNR1
20	Neuroscience3	9.2	GAD2, GAD1, GABBR1, PLXNA2, NTRK3, HTR1A
21	Intracellular Calcium Signaling36	8.8	NTRK3, PTK7, HTR3A, HTR2C, HTR2A, HTR1B
22	Neuroactive ligand-receptor interaction20	7.8	CNR1, TSPO, TACR1, PRL, GABBR1, CRHR2

Compounds related to anxiety disorder according to GeneDecks:

(show top 50)    (show all 476)

id	Compound	Score	Top Affiliating Genes
1	mianserin32 9 9	12.0	SLC6A4, SLC6A2, CYP2D6, CYP3A4, HTR3A, HTR2C
2	yohimbine32 9 9	12.0	HTR2C, HTR1A, CCKBR, DRD2, NPY, CRH
3	nicotine32 34 9 9	12.9	CCKBR, CYP2D6, NR3C2, SLC6A2, OXT, CRH
4	bromocriptine32 9 9	11.9	GAL, PRL, CYP3A4, HTR2C, HTR2A, HTR1A
5	methylphenidate32 9 9	11.8	MAOA, MAOB, SLC6A4, SLC6A3, SLC6A2, COMT
6	sertraline32 34 9 18 9	13.8	SLC6A4, SLC6A3, SLC6A2, CRH, CYP2D6, CYP3A4
7	5-hydroxytryptophan32	9.8	HTR1A, SLC6A4, PRL, CRH, PTK7, TPH1
8	amitriptyline32 34 42 9 9	13.7	HTR3A, HTR2A, HTR1A, MAOB, MAOA, CYP3A4
9	ritanserin32	9.7	HTR1B, HTR1A, HTR2A, HTR2C, PRL, DRD2
10	fluvoxamine32 34 9 9	12.7	SLC6A4, SLC6A3, SLC6A2, TSPO, CYP2D6, CYP3A4
11	nefazodone34 32 9 9	12.5	SLC6A3, SLC6A2, CYP2D6, CYP3A4, HTR3A, HTR2C
12	methamphetamine32 9 9	11.5	TPH1, MAOB, MAOA, BDNF, DRD2, DRD4
13	trimipramine32 34 9 9	12.5	SLC6A4, SLC6A3, SLC6A2, PRL, CYP2D6, CYP3A4
14	mptp32	9.5	COMT, DRD2, MAOB, MAOA, BDNF, TSPO
15	bupropion32 34 9 18 9	13.5	SLC6A4, SLC6A3, SLC6A2, NPY, CYP2D6, CYP3A4
16	ropinirole32 9 9	11.5	COMT, CYP2D6, CYP3A4, DRD4, DRD2, HTR2C
17	tetrodotoxin32	9.5	GAD2, GAL, GAD1, NPY, TACR1, CRH
18	epinephrine32 9 18 9	12.5	GAL, SLC6A4, SLC6A2, NPY, COMT, CRH
19	choline32 9 18 9	12.3	P2RX7, GAD2, GAL, GAD1, NPY, OXT
20	cabergoline32 9 9	11.3	HTR1B, HTR1A, HTR2A, PRL, COMT, CYP3A4
21	pramipexole32 9 9	11.3	DRD4, DRD2, HTR2C, HTR2A, HTR1B, HTR1A
22	catecholamine32	9.3	BDNF, MAOA, SLC6A2, NPY, COMT, CRHR1
23	lisuride32 9 9	11.3	DRD4, DRD2, HTR2C, HTR2A, HTR1B, HTR1A
24	maoa32	9.2	SLC6A4, SLC6A3, SLC6A2, MAOA, BDNF, MAOB
25	aripiprazole32 34 9 18 9	13.2	DRD2, HTR3A, HTR2C, HTR2A, HTR1B, HTR1A
26	venlafaxine32 34 9 18 9	13.2	CYP3A4, TPH2, HTR3A, HTR2A, HTR1B, HTR1A
27	pergolide32 9 9	11.2	CYP2D6, CYP3A4, DRD4, DRD2, HTR2C, HTR2A
28	ziprasidone32 9 9	11.1	PRL, HTR1A, CYP2D6, CYP3A4, DRD4, DRD2
29	mirtazapine32 34 9 9	12.1	SLC6A4, PRL, CRH, NR3C1, CYP2D6, CYP3A4
30	haloperidol32 34 9 9	12.0	HTR2A, HTR1A, CCKBR, MAOB, BDNF, HTR3A
31	amphetamine32 9 9	11.0	GAL, GABBR1, SLC6A4, SLC6A3, SLC6A2, NPY
32	desipramine32 34 9 9	12.0	NR3C1, CYP2D6, CYP3A4, HTR2A, HTR1A, MAOA
33	quetiapine32 9 18 9	12.0	DRD4, DRD2, HTR3A, HTR2C, HTR2A, HTR1B
34	olanzapine32 34 9 18 9	12.9	DRD2, HTR3A, HTR2C, HTR2A, HTR1B, HTR1A
35	opiate32	8.8	GABBR1, SLC6A4, SLC6A3, NPY, PRL, OXT
36	citalopram32 34 9 18 9	12.7	SLC6A4, SLC6A3, SLC6A2, HTR1A, MAOB, MAOA
37	clomipramine32 34 9 9	11.7	SLC6A4, SLC6A3, HTR1A, MAOA, FKBP5, HTR2A
38	apomorphine32 9 9	10.7	SLC6A3, PRL, OXT, COMT, DRD4, DRD2
39	paroxetine32 34 9 9	11.6	HTR3A, HTR2A, HTR1B, HTR1A, MAOA, FKBP5
40	acth32	8.5	GAL, NPY, PRL, OXT, CRHR2, CRHR1
41	levodopa32 9 9	10.2	GAL, GAD1, SLC6A3, PRL, TSPO, COMT
42	fluoxetine32 34 9 9	10.9	SLC6A4, SLC6A3, SLC6A2, PRL, OXT, TACR1
43	nmda32 42	8.9	SLC6A3, NPY, TACR1, TSPO, COMT, NTRK3
44	5-hydroxytryptamine32	7.8	DRD2, CNR1, MAOA, MAOB, TPH2, TPH1
45	acetylcholine32 9 18 9	10.3	GAD2, GAL, GAD1, GABBR1, SLC6A3, SLC6A2
46	cocaine32 9 9	9.3	PRL, HTR1B, CCK, CCKBR, MAOB, BDNF
47	norepinephrine32 9 18 9	10.0	NR3C2, MAOA, BDNF, CNR1, MAOB, CCK
48	testosterone32 9 18 9	10.0	NTRK3, CYP2D6, CYP3A4, HSP90AA1, HTR1B, CCK
49	dopamine32 9 18 9	9.5	NR3C1, MAOB, MAOA, BDNF, CCKBR, CCK
50	gaba32 42	7.2	OXT, TSPO, CRHR1, CRH, NR3C1, PTK7

Cellular components related to anxiety disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon hillock	GO:043203	10.3	CCK, HTR1A
2	terminal button	GO:043195	9.5	P2RX7, CCK, DRD4, OXT
3	axon	GO:030424	9.4	GAD2, SLC6A1, SLC6A3, DRD2, HTR3A, CCK
4	integral to plasma membrane	GO:005887	7.1	CNR1, CRHR1, CRHR2, PLXNA2, TACR1, SLC6A2
5	plasma membrane	GO:005886	5.6	CRHR2, PLXNA2, COMT, TACR1, SLC6A2, SLC6A3

Biological processes related to anxiety disorder according to GeneDecks:

(show all 44)

id	Name	GO ID	Score	Top Affiliating Genes
1	monoamine transport	GO:015844	10.6	SLC6A4, SLC6A3, SLC6A2
2	dopamine catabolic process	GO:042420	10.6	MAOA, COMT, SLC6A3
3	serotonin receptor signaling pathway	GO:007210	10.6	HTR3A, HTR2C, HTR2A
4	sperm ejaculation	GO:042713	10.5	SLC6A4, OXT, TACR1
5	ERK1 and ERK2 cascade	GO:070371	10.5	HTR2C, HTR2A, CCKBR
6	regulation of sensory perception of pain	GO:051930	10.5	CCKBR, CCK, OXT
7	synaptic transmission, dopaminergic	GO:001963	10.4	CRH, DRD4, DRD2
8	memory	GO:007613	10.4	SLC6A4, OXT, HTR2A, CNR1
9	behavior	GO:007610	10.4	NPY, TACR1, HTR1A, MAOA, CNR1
10	positive regulation of blood pressure	GO:045777	10.4	OXT, TACR1, CNR1
11	negative regulation of blood pressure	GO:045776	10.4	NPY, OXT, DRD2, CNR1
12	positive regulation of mitochondrial depolarization	GO:051901	10.4	TSPO, CCK, P2RX7
13	serotonin biosynthetic process	GO:042427	10.4	TPH2, TPH1
14	positive regulation of renal sodium excretion	GO:035815	10.4	OXT, TACR1, DRD2
15	glutamate decarboxylation to succinate	GO:006540	10.3	GAD1, GAD2
16	eating behavior	GO:042755	10.3	OXT, TACR1, CCK
17	negative regulation of synaptic transmission, glutamatergic	GO:051967	10.3	DRD2, HTR2A, HTR1B
18	regulation of dopamine secretion	GO:014059	10.3	HTR1B, HTR2A, DRD2
19	positive regulation of dopamine uptake involved in synaptic transmission	GO:051586	10.3	DRD2, DRD4
20	negative regulation of adenylate cyclase activity	GO:007194	10.3	GABBR1, DRD4, DRD2
21	response to nicotine	GO:035094	10.2	CNR1, DRD2, TACR1, SLC6A3, GABBR1
22	long-term memory	GO:007616	10.2	DRD2, CRH, TACR1
23	response to stress	GO:006950	10.2	CNR1, P2RX4, HTR2A, TPH1, TPH2
24	release of sequestered calcium ion into cytosol	GO:051209	10.2	P2RX7, HTR2A, HTR2C, DRD2
25	positive regulation of prostaglandin secretion	GO:032308	10.2	OXT, P2RX7, P2RX4
26	neurotransmitter biosynthetic process	GO:042136	10.2	GAD2, GAD1, SLC6A3, COMT, MAOA
27	response to morphine	GO:043278	10.2	TACR1, DRD2, CNR1
28	response to histamine	GO:034776	10.2	DRD4, DRD2
29	response to toxin	GO:009636	10.2	SLC6A4, SLC6A1, DRD2, MAOB
30	negative regulation of dopamine secretion	GO:033602	10.1	GABBR1, CNR1
31	feeding behavior	GO:007631	10.1	GAL, NPY, CRH, DRD2, HTR2C, CCKBR
32	regulation of sodium ion transport	GO:002028	10.1	P2RX4, P2RX7, DRD2
33	alkaloid catabolic process	GO:009822	10.1	CYP2D6, CYP3A4
34	xenobiotic metabolic process	GO:006805	10.1	COMT, CYP2D6, CYP3A4, MAOB, MAOA
35	adrenal gland development	GO:030325	10.1	TSPO, CRH, NR3C1
36	neurotransmitter secretion	GO:007269	10.0	GAD2, GAD1, SLC6A1, MAOA
37	aging	GO:007568	10.0	SLC6A3, TSPO, NR3C1, HTR2A, CNR1
38	sensory perception of pain	GO:019233	10.0	TACR1, HTR2A, P2RX7, P2RX4, CNR1
39	response to ethanol	GO:045471	10.0	GABBR1, SLC6A3, TACR1, HTR1B, MAOB, CNR1
40	female pregnancy	GO:007565	10.0	CRH, CRHR1, COMT, OXT, PRL
41	response to cocaine	GO:042220	9.8	SLC6A1, SLC6A3, OXT, DRD2, HTR3A, HTR1B
42	positive regulation of gamma-aminobutyric acid secretion	GO:014054	9.6	SLC6A1, P2RX7
43	synaptic transmission	GO:007268	9.0	SLC6A2, SLC6A3, SLC6A1, GABBR1, GAD1, GAD2
44	response to drug	GO:042493	8.8	BDNF, GAD2, GAL, GAD1, SLC6A4, SLC6A3

Molecular functions related to anxiety disorder according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	monoamine transmembrane transporter activity	GO:008504	10.4	SLC6A2, SLC6A3, SLC6A4
2	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	GO:071886	10.4	HTR2C, HTR2A
3	neuropeptide hormone activity	GO:005184	10.3	GAL, NPY, CRH, CCK
4	tryptophan 5-monooxygenase activity	GO:004510	10.2	TPH2, TPH1
5	dopamine binding	GO:035240	10.2	SLC6A3, DRD4, DRD2
6	corticotrophin-releasing factor receptor activity	GO:015056	10.2	CRHR2, CRHR1
7	serotonin receptor activity	GO:004993	10.1	HTR3A, HTR2C, HTR2A, HTR1B, HTR1A
8	serotonin binding	GO:051378	10.0	HTR3A, HTR2C, HTR2A, HTR1B, HTR1A, MAOA
9	glutamate decarboxylase activity	GO:004351	10.0	GAD1, GAD2
10	dopamine receptor activity, coupled via Gi/Go	GO:001591	9.9	DRD2, DRD4
11	drug binding	GO:008144	9.5	CNR1, SLC6A3, CYP2D6, DRD4, DRD2, HTR2C
12	steroid binding	GO:005496	9.0	NR3C2, NR3C1, CYP3A4, ESR1