MCID: ANX002
MIFTS: 75

Anxiety Disorder malady

Neuronal diseases category

Summaries for Anxiety Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Fear and anxiety are part of life. you may feel anxious before you take a test or walk down a dark street. this kind of anxiety is useful - it can make you more alert or careful. it usually ends soon after you are out of the situation that caused it. but for millions of people in the united states, the anxiety does not go away, and gets worse over time. they may have chest pains or nightmares. they may even be afraid to leave home. these people have anxiety disorders. types include panic disorder obsessive-compulsive disorder post-traumatic stress disorder phobias generalized anxiety disorder treatment can involve medicines, therapy or both. nih: national institute of mental health

MalaCards: Anxiety Disorder, also known as anxiety disorders, is related to generalized anxiety disorder and panic disorder. An important gene associated with Anxiety Disorder is HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled), and among its related pathways are Citalopram Pathway, Pharmacokinetics and Enzymatic degradation of dopamine by COMT. The drugs amobarbital and diphenhydramine hydrochloride and the compounds mianserin and venlafaxine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are renal/urinary system and muscle.

Disease Ontology:8 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:63 Anxiety disorders are a group of mental disorders characterized by excessive feelings of anxiety and... more...

Aliases & Classifications for Anxiety Disorder

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

anxiety disorder 8 22 10
anxiety disorders 44 60
anxiety neurosis 60
anxiety state 8
anxiety 33


External Ids:

Disease Ontology8 DOID:2030
MeSH34 D001008
NCIt39 C2878
ICD1025 F41.8, F41.9

Related Diseases for Anxiety Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Anxiety Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 424)
idRelated DiseaseScoreTop Affiliating Genes
1generalized anxiety disorder31.9HTR1A, SLC6A4, TSPO
2panic disorder31.2SLC6A4, CRH, HTR3A, HTR1A, CCKBR, TSPO
3social phobia31.0SLC6A4, MAOA, OXT, HTR3A, HTR1A, COMT
4mood disorder30.9NPY, HTR2A, HTR3A, HTR1A, HTR2C, COMT
5bipolar disorder30.8HTR1A, SLC6A4
6personality disorder30.8DRD4, MAOA, SLC6A3, SLC6A4, TPH1, TPH2
7obsessive-compulsive disorder30.8HTR1A, COMT, HTR3A, HTR2A, DRD4, TPH2
8agoraphobia30.7SLC6A2, MAOA, HTR1A, CCKBR
9alcohol dependence30.6SLC6A4, CNR1, MAOA, CRH, DRD4, NPY
10dysthymic disorder30.4HTR2A, MAOA
11substance abuse30.3SLC6A4, SLC6A3, CNR1, CRH, DRD4
12nicotine dependence30.3DRD4, SLC6A4
13antisocial personality disorder30.3HTR2A, MAOA, SLC6A3, SLC6A4
14attention deficit hyperactivity disorder30.3DRD4, SLC6A3
15eating disorder30.3SLC6A4, SLC6A3, CNR1, CRH, NPY, HTR2A
16psychotic disorder30.3COMT, HTR2C, HTR1A, HTR3A, TPH2, TPH1
17migraine30.2TPH1, SLC6A4, SLC6A3, CNR1, MAOA, DRD4
18irritable bowel syndrome30.2HTR3A, CRH, SLC6A4, TPH1
19alcohol abuse30.2SLC6A4, SLC6A3, COMT
20narcolepsy30.2COMT, HTR2A
21drug dependence30.2MAOA, CNR1, SLC6A4, SLC6A3
22withdrawal disorder30.2CRH, CNR1
23schizophrenia30.2COMT, HTR2A
24anorexia nervosa30.2HTR2A, HTR3A, HTR1A, HTR2C, COMT, TPH1
25hepatitis30.1COMT
26breast cancer30.1CNR1, OXT, HTR3A, COMT
27obesity30.1DRD4, NPY, HTR2A, HTR1A, HTR2C, CCKBR
28pathological gambling30.0DRD4, SLC6A3
29borderline personality disorder30.0TPH1, SLC6A4, MAOA, OXT
30conduct disorder30.0COMT, DRD4, MAOA, SLC6A3, SLC6A4
31dementia30.0COMT, HTR1A, HTR3A, HTR2A, MAOA, SLC6A3
32substance dependence30.0COMT, DRD4, CNR1, SLC6A3, SLC6A4, TPH1
33premature ejaculation30.0SLC6A4, HTR1A
34dermatitis30.0HARS
35alzheimer's disease30.0COMT, HTR2C, HTR1A, HTR2A, NPY, DRD4
36melancholia29.9CRH, MAOA
37bulimia nervosa29.9SLC6A4, MAOA, NPY, HTR2A, HTR3A, COMT
38dyspepsia29.8HTR3A
39neuroleptic malignant syndrome29.8HTR1A
40chronic fatigue syndrome29.8SLC6A4, MAOA, CRH, HTR1A
41hypertension29.8SLC6A4, RGS2, CRH, NPY
42schizoaffective disorder29.8COMT, HTR2A, DRD4, SLC6A4
43autistic disorder29.8HTR1A, HTR3A, HTR2A, OXT, SLC6A4
44myocardial infarction29.8COMT, HTR3A, HTR2A, NPY, CNR1, SLC6A4
45cannabis dependence29.8CNR1
46opiate dependence29.8CCKBR
47parkinson's disease29.8DRD4, HTR2A, HTR3A, HTR1A, HTR2C, CCKBR
48asthma29.8TSPO, CNR1, HTR2A
49paranoid schizophrenia29.8COMT
50ischemia29.8SLC6A3, CNR1, HTR1A, SLC6A2

Graphical network of the top 20 diseases related to Anxiety Disorder:



Diseases related to anxiety disorder

Clinical Features for Anxiety Disorder

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Drugs & Therapeutics for Anxiety Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Anxiety Disorder

Search NIH Clinical Center for Anxiety Disorder

Highlights from CenterWatch's Drugs in Clinical Trials Database for Anxiety Disorder:

idCompanyCompoundMechanismPhase
1Ironwood PharmaceuticalsIW-2143/BNC210A small molecule anxiolyticI
2Pherin PharmaceuticalsAloradine nasal sprayAn intranasal spray that acts with rapid-onset on peripheral receptors from nasal chemosensory neurons IIb
3Janssen Pharmaceuticals/Addex PharmaceuticalsJNJ-40411813A mGluR2 positive allosteric modulatorII

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Anxiety Disorder

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Sources:
22GTR
See all sources

Genetic tests related to Anxiety Disorder:

id Genetic test Affiliating Genes
1 Anxiety22

Anatomical Context for Anxiety Disorder

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32MalaCards
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MalaCards organs/tissues related to Anxiety Disorder:

32
Heart, Testes, Brain, Cortex, Amygdala, Cingulate cortex, Eye, Prefrontal cortex, Thyroid, Temporal lobe, Fetal brain, Ovary, Hypothalamus, Prostate, Pituitary, Liver, Monocytes, Lung

Animal Models for Anxiety Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Anxiety Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1COMT, CCKBR, HTR3A, NPY, OXT, RGS2
2MP:000536910.0SLC6A4, SLC6A3, RGS2, HTR2A, HTR3A, HTR2C
3MP:00053859.9COMT, CCKBR, HTR1A, OXT, MAOA, RGS2
4MP:00107719.9HTR2C, HTR3A, CRH, OXT, CNR1, SLC6A4
5MP:00053789.9SLC6A4, TPH1, SLC6A2, SLC6A3, CNR1, CRH
6MP:00053799.7CCKBR, HTR3A, HTR2A, CRH, OXT, SLC6A3
7MP:00036319.6COMT, CCKBR, HTR2C, HTR1A, HTR3A, NPY
8MP:00053769.6CCKBR, TPH2, TPH1, COMT, HTR2C, SLC6A2
9MP:00053869.6SLC6A3, CCKBR, HTR2C, TPH2, TPH1, SLC6A2

Publications for Anxiety Disorder

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Sources:
50PubMed
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Articles related to Anxiety Disorder:

(show top 50)    (show all 1248)
idTitleAuthorsYear
1
A randomised, double-blind, placebo-controlled, duloxetine-referenced study of the efficacy and tolerability of vortioxetine in the acute treatment of adults with generalised anxiety disorder. (24341301)
2014
2
Adult separation anxiety disorder in DSM-5. (23673209)
2013
3
Is adolescent generalized anxiety disorder a magnet for negative parental interpersonal behaviors? (23390021)
2013
4
How well do randomized controlled trial data generalize to 'real-world' clinical practice settings? A comparison of two generalized anxiety disorder studies. (24290532)
2013
5
Using the GAD-Q-IV to identify generalized anxiety disorder in psychiatric treatment seeking and primary care medical samples. (24334213)
2013
6
Interpersonal constraint conferred by generalized social anxiety disorder is evident on a behavioral economics task. (23231458)
2013
7
Neural response to the observable self in social anxiety disorder. (22895096)
2013
8
Altered neural correlates of affective processing after internet-delivered cognitive behavior therapy for social anxiety disorder. (24064198)
2013
9
Lack of efficacy of L-759274, a novel neurokinin 1 (substance P) receptor antagonist, for the treatment of generalized anxiety disorder. (22433185)
2013
10
Prevalence of psychotic-like experiences in young adults with social anxiety disorder and correlation with affective dysregulation. (24284640)
2013
11
Information-seeking bias in social anxiety disorder. (22905860)
2013
12
Reduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorder. (23706841)
2013
13
Heart rate and autonomic response to stress after experimental induction of worry versus relaxation in healthy, high-worry, and generalized anxiety disorder individuals. (23384513)
2013
14
Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder. (23452685)
2013
15
Therapist behaviours in internet-delivered cognitive behaviour therapy: analyses of e-mail correspondence in the treatment of generalized anxiety disorder. (22717145)
2013
16
A clinical research practice datalink analysis of antidepressant treatment patterns and health care costs in generalized anxiety disorder. (24326166)
2013
17
Targeted Behavioral Therapy for childhood generalized anxiety disorder: A time-series analysis of changes in anxiety and sleep. (24289931)
2013
18
Plasma oxytocin immunoreactive products and response to trust in patients with social anxiety disorder. (22807189)
2012
19
Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. (22945621)
2012
20
Change in healthcare utilization and costs following initiation of benzodiazepine therapy for long-term treatment of generalized anxiety disorder: a retrospective cohort study. (23088742)
2012
21
Relations between behavioral inhibition, big five personality factors, and anxiety disorder symptoms in non-clinical and clinically anxious children. (22528030)
2012
22
Dimensional indicators of generalized anxiety disorder severity for DSM-V. (22245699)
2012
23
The extent and nature of imagery during worry and positive thinking in generalized anxiety disorder. (21842960)
2012
24
Effects of analytical and experiential self-focus on rumination after a stress induction in patients with social anxiety disorder: a pilot study. (22536750)
2012
25
Assessment of quality of life enjoyment and satisfaction questionnaire-short form responder thresholds in generalized anxiety disorder and bipolar disorder studies. (21164351)
2011
26
Number needed to treat to harm for discontinuation due to adverse events in the treatment of bipolar depression, major depressive disorder, and generalized anxiety disorder with atypical antipsychotics. (21034695)
2011
27
Generalized anxiety disorder: clinical presentation, diagnostic features, and guidelines for clinical practice. (20973033)
2011
28
The role of values-consistent behavior in generalized anxiety disorder. (21308890)
2011
29
Augmentative quetiapine in partial/nonresponders with generalized anxiety disorder: a randomized, placebo-controlled study. (21403524)
2011
30
A community study of generalized anxiety disorder with vs. without health anxiety in Hong Kong. (21109390)
2011
31
Comorbid anxiety disorders and baseline medication regimens predict clinical outcomes in individuals with co-occurring bipolar disorder and alcohol dependence: Results of a randomized controlled trial. (21641663)
2011
32
Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. (20123913)
2010
33
Impairment and functioning in a sample of primary care patients with generalized anxiety disorder: results from the primary care anxiety project. (21274362)
2010
34
Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults. (21105279)
2010
35
Adult separation anxiety disorder among war-affected Bosnian refugees: comorbidity with PTSD and associations with dimensions of trauma. (20135680)
2010
36
The serotonin-1A receptor in anxiety disorders. (19423077)
2009
37
Impact of gastrointestinal symptoms on response to pregabalin in generalized anxiety disorder: results of a six-study combined analysis. (19352198)
2009
38
Systematic review and quality assessment of economic evaluations and quality-of-life studies related to generalized anxiety disorder. (19695395)
2009
39
Age at onset of generalized anxiety disorder in older adults. (19472431)
2009
40
The association between anxiety and alcohol versus cannabis abuse disorders among adolescents in primary care settings. (18753288)
2008
41
Increased serotonin and dopamine transporter binding in psychotropic medication-naive patients with generalized social anxiety disorder shown by 123I-beta-(4-iodophenyl)-tropane SPECT. (18413401)
2008
42
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (17898336)
2007
43
Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. (16718280)
2006
44
Attention deficit hyperactivity disorder, combined type, dysthymic disorder and anxiety disorders: differential patterns of neurodevelopmental deficits. (16876876)
2006
45
New pharmacological treatment approaches for anxiety disorders. (16594270)
2005
46
Social anxiety in body dysmorphic disorder. (17075614)
2005
47
The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. (11430844)
2001
48
Benzodiazepine-induced chemotaxis is impaired in monocytes from patients with generalized anxiety disorder. (10101731)
1999
49
Sertraline treatment of transition-associated anxiety and agitation in children with autistic disorder. (9192538)
1997
50
Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. (8643680)
1996

Genetic Variations for Anxiety Disorder

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Expression for genes affiliated with Anxiety Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Anxiety Disorder

Search GEO for disease gene expression data for Anxiety Disorder.

Pathways for genes affiliated with Anxiety Disorder

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Sources:
49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Anxiety Disorder according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4SLC6A4, SLC6A2
2
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10.4MAOA, SLC6A3
3
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10.4TPH1, TPH2
4
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10.4TPH1, TPH2
5
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10.4TPH1, TPH2
6
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10.3TPH2, TPH1, MAOA
7
Hide members
10.3MAOA, TPH1, TPH2
810.3CCKBR, HTR2A, DRD4
910.2CRH, NPY, MAOA, SLC6A3
1010.2TPH2, SLC6A2, SLC6A4, SLC6A3
11
Hide members
10.2OXT, CCKBR, HTR2C, HTR2A
1210.1TPH2, TPH1, SLC6A4, HTR2A, HTR3A, HTR1A
13
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10.1DRD4, HTR2C, HTR1A, HTR3A, HTR2A, MAOA
14
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9.9CCKBR, HTR2A, DRD4, CNR1, OXT, HTR2C
15
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9.9HTR2C, COMT, CNR1, HTR1A, HTR3A, HTR2A
16
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9.8TSPO, CNR1, OXT, CRH, NPY, HTR2A

Compounds for genes affiliated with Anxiety Disorder

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Anxiety Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 362)
idCompoundScoreTop Affiliating Genes
1mianserin28 44 1112.5HTR2C, HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
2venlafaxine49 44 11 2413.5HTR1A, HTR3A, HTR2A, SLC6A3, SLC6A4, SLC6A2
3mdma4410.5TPH1, SLC6A2, SLC6A4, SLC6A3, MAOA, HTR1A
4sertraline44 28 49 11 2414.5SLC6A4, SLC6A3, MAOA, HTR1A, HTR3A, CRH
5nefazodone44 49 1112.5HTR2C, HTR1A, HTR3A, HTR2A, SLC6A3, SLC6A4
6carbon-114410.5TSPO, SLC6A4, SLC6A3, MAOA, HTR1A
75-hydroxytryptophan4410.5HTR2A, TPH1, SLC6A4, CRH, HTR1A, HTR3A
8p-chloroamphetamine4410.5SLC6A2, SLC6A4, SLC6A3, MAOA, HTR1A
9mhpg4410.5COMT, NPY, DRD4, CRH, MAOA, SLC6A4
10amitriptyline44 49 28 1113.4HTR1A, HTR3A, HTR2A, MAOA, SLC6A3, SLC6A4
11fluvoxamine44 49 1112.4HTR1A, HTR3A, HTR2A, MAOA, SLC6A3, SLC6A4
12methamphetamine44 49 1112.4DRD4, MAOA, SLC6A3, SLC6A4, SLC6A2, TPH1
13desipramine44 49 1112.4HTR1A, HTR2A, CRH, MAOA, CNR1, SLC6A3
14yohimbine44 28 2 1113.4NPY, HTR2A, HTR1A, CCKBR, HTR2C, CRH
15citalopram49 44 11 2413.4HTR2C, HTR1A, HTR3A, HTR2A, MAOA, SLC6A3
16homovanillic acid44 2411.4SLC6A4, SLC6A2, CRH, COMT, MAOA, TPH1
17methylphenidate44 49 1112.4DRD4, SLC6A2, SLC6A4, SLC6A3, MAOA, COMT
18mirtazapine49 44 1112.4HTR3A, HTR2C, CRH, TPH2, SLC6A4, HTR2A
19nmda44 2811.4TSPO, MAOA, CNR1, HTR1A, SLC6A3, COMT
20fenfluramine28 44 1112.4NPY, CRH, SLC6A4, TPH1, TPH2, HTR2A
21risperidone28 44 49 59 11 2415.4COMT, HTR2C, HTR1A, HTR3A, HTR2A, DRD4
22m-chlorophenylpiperazine4410.4HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
235-hydroxyindoleacetic acid44 2411.4SLC6A2, TPH1, CRH, MAOA, SLC6A4, HTR3A
24pramipexole44 49 28 1113.4HTR2C, COMT, HTR1A, HTR2A, DRD4, SLC6A3
25amphetamine44 1111.4MAOA, CNR1, SLC6A3, SLC6A4, SLC6A2, TPH1
26apomorphine44 28 1112.3COMT, HTR2C, HTR1A, HTR2A, DRD4, OXT
27haloperidol44 28 2 49 1114.3CCKBR, HTR1A, HTR3A, HTR2A, NPY, DRD4
283,4-Methylenedioxymethamphetamine1110.3SLC6A2, SLC6A4, SLC6A3, HTR2C, HTR2A
29levodopa44 1111.3MAOA, COMT, CNR1, TPH1, HTR1A, TSPO
30paroxetine44 49 28 1113.3COMT, HTR1A, HTR3A, HTR2A, DRD4, MAOA
31quinpirole44 2811.3SLC6A3, RGS2, CNR1, DRD4, HTR2A, HTR2C
32clozapine44 28 49 1113.3HTR1A, HTR3A, HTR2A, DRD4, SLC6A3, SLC6A4
33clomipramine44 49 1112.3HTR2A, HTR3A, HTR1A, HTR2C, CRH, MAOA
34maoa4410.3COMT, HTR2C, HTR1A, HTR2A, DRD4, MAOA
35MMDA1110.3MAOA, SLC6A3, SLC6A4, SLC6A2, HTR2A
36olanzapine49 44 28 11 2414.3HTR2A, SLC6A3, HTR1A, HTR3A, DRD4, HTR2C
37acetylcholine44 49 28 11 2414.2CCKBR, HTR2C, HTR1A, HTR3A, NPY, CRH
38d amphetamine4410.2SLC6A3, SLC6A2, MAOA, SLC6A4, TSPO
39imipramine44 49 28 11 2414.2HTR1A, SLC6A2, SLC6A4, SLC6A3, MAOA, HTR2A
40ipsapirone44 2811.2OXT, HTR2A, HTR3A, HTR2C, HTR1A
41cocaine44 1111.2SLC6A2, SLC6A4, SLC6A3, CCKBR, COMT, HTR2C
42fluoxetine49 44 28 1113.1HTR2A, CRH, OXT, MAOA, CNR1, SLC6A3
43mcpp4410.1HTR2C, HTR1A, HTR3A, HTR2A, SLC6A4
44gaba4410.1TPH1, HTR2C, HTR3A, NPY, DRD4, CRH
45nicotine44 49 28 1113.1COMT, CCKBR, NPY, DRD4, CRH, OXT
46glutamate4410.0TPH1, CRH, NPY, HTR2C, OXT, MAOA
475-hydroxytryptamine449.9COMT, HTR2C, HTR1A, HTR3A, HTR2A, NPY
48norepinephrine44 11 2411.9COMT, HTR2C, HTR1A, HTR3A, HTR2A, NPY
49dopamine44 28 11 2412.8COMT, CCKBR, HTR2C, HTR1A, HTR3A, TPH1
50bupropion44 49 11 2412.8SLC6A2, SLC6A3, CNR1, COMT, NPY, SLC6A4

GO Terms for genes affiliated with Anxiety Disorder

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Sources:
16Gene Ontology
See all sources

Cellular components related to Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.7CCKBR, HTR2C, HTR1A, HTR3A, HTR2A, DRD4
2integral to plasma membraneGO:0058879.6SLC6A2, CCKBR, HTR2C, HTR1A, HTR3A, HTR2A

Biological processes related to Anxiety Disorder according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:01406210.7CRH, HTR1A
2phospholipase C-activating serotonin receptor signaling pathwayGO:00720810.7HTR2A, HTR2C
3monoamine transportGO:01584410.7SLC6A2, SLC6A4, SLC6A3
4regulation of hormone secretionGO:04688310.7HTR1A, HTR2A
5dopamine catabolic processGO:04242010.7SLC6A3, MAOA, COMT
6regulation of dopamine metabolic processGO:04205310.7HTR1A, DRD4, SLC6A3
7neurotransmitter biosynthetic processGO:04213610.7COMT, MAOA, SLC6A3
8serotonin biosynthetic processGO:04242710.7TPH1, TPH2
9serotonin receptor signaling pathwayGO:00721010.7HTR2C, HTR1A, HTR3A, HTR2A
10agingGO:00756810.7HTR2A, CNR1, TSPO
11aromatic amino acid family metabolic processGO:00907210.7TPH1, TPH2
12response to painGO:04826510.7SLC6A2, CRH, COMT
13behavioral fear responseGO:00166210.7DRD4, HTR1A, HTR2C
14response to immobilization stressGO:03590210.6CRH, TPH1
15feeding behaviorGO:00763110.6CCKBR, HTR2C, NPY, CRH
16positive regulation of phosphatidylinositol biosynthetic processGO:01051310.6HTR2C, HTR2A
17behaviorGO:00761010.6NPY, MAOA, CNR1
18response to etherGO:04547210.6CRH, OXT
19negative regulation of blood pressureGO:04577610.6CRH, OXT, CNR1
20response to cocaineGO:04222010.6HTR3A, OXT, CNR1, SLC6A3
21indolalkylamine biosynthetic processGO:04621910.6TPH1, TPH2
22social behaviorGO:03517610.6SLC6A4, OXT, DRD4
23memoryGO:00761310.6SLC6A4, CNR1, OXT, HTR2A
24circadian rhythmGO:00762310.6TPH2, TPH1, SLC6A4
25sperm ejaculationGO:04271310.5SLC6A4, OXT
26neurotransmitter catabolic processGO:04213510.5MAOA, COMT
27digestionGO:00758610.5NPY, HTR3A, CCKBR
28sleepGO:03043110.5HTR2A, OXT
29response to drugGO:04249310.5COMT, HTR2C, HTR2A, CRH, SLC6A3, SLC6A4
30cellular calcium ion homeostasisGO:00687410.4DRD4, HTR2A, HTR2C
31synaptic transmissionGO:00726810.4SLC6A2, COMT, HTR2C, HTR3A, HTR2A, NPY
32response to ethanolGO:04547110.3CRH, CNR1, SLC6A3
33regulation of behaviorGO:05079510.3HTR1A, HTR2A
34response to stressGO:00695010.3TPH2, CNR1, HTR2A
35female pregnancyGO:00756510.3COMT, CRH, OXT
36synaptic transmission, dopaminergicGO:00196310.0DRD4, CRH

Molecular functions related to Anxiety Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.4SLC6A3, SLC6A4, SLC6A2
2serotonin receptor activityGO:00499310.4HTR2C, HTR1A, HTR3A, HTR2A
3dopamine bindingGO:03524010.3SLC6A3, DRD4
4serotonin bindingGO:05137810.3HTR2A, HTR3A, HTR2C
5drug bindingGO:00814410.3SLC6A3, CNR1, DRD4, HTR2A, HTR2C
61-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:07188610.3HTR2C, HTR2A
7tryptophan 5-monooxygenase activityGO:00451010.1TPH1, TPH2

Products for genes affiliated with Anxiety Disorder

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Sources for Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet