MCID: ANX002
MIFTS: 60

Anxiety Disorder malady

Mental diseases, Neuronal diseases categories

Aliases & Classifications for Anxiety Disorder

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Sources:
9Disease Ontology, 11DISEASES, 60UMLS, 43Novoseek, 22GTR, 32MedlinePlus, 33MeSH, 55SNOMED-CT, 38NCIt, 25ICD10
See all sources

Anxiety Disorder, Aliases & Descriptions:

Name: Anxiety Disorder 9 11
Anxiety Disorders 43 22 60
Anxiety State 9 60
 
Anxiety Neurosis 60
Anxiety 32


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology9 DOID:2030
MeSH33 D001008
NCIt38 C2878
ICD1025 F41.8, F41.9

Summaries for Anxiety Disorder

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MedlinePlus:32 Fear and anxiety are part of life. you may feel anxious before you take a test or walk down a dark street. this kind of anxiety is useful - it can make you more alert or careful. it usually ends soon after you are out of the situation that caused it. but for millions of people in the united states, the anxiety does not go away, and gets worse over time. they may have chest pains or nightmares. they may even be afraid to leave home. these people have anxiety disorders. types include panic disorder obsessive-compulsive disorder post-traumatic stress disorder phobias generalized anxiety disorder treatment can involve medicines, therapy or both. nih: national institute of mental health

MalaCards based summary: Anxiety Disorder, also known as anxiety disorders, is related to generalized anxiety disorder and panic disorder. An important gene associated with Anxiety Disorder is TSPO (translocator protein (18kDa)), and among its related pathways are Venlafaxine Pathway, Pharmacokinetics and Monoamine GPCRs. The drugs amobarbital and diphenhydramine hydrochloride and the compounds p-chlorophenylalanine and milnacipran have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are nervous system and cardiovascular system.

Disease Ontology:9 A cognitive disorder that involves an excessive, irrational dread of everyday situations.

Wikipedia:63 Anxiety disorders are a category of mental disorders characterized by feelings of anxiety and fear,... more...

Related Diseases for Anxiety Disorder

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Diseases related to Anxiety Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1generalized anxiety disorder32.1TSPO, HTR1A, SLC6A4
2panic disorder31.1TSPO, CCKBR, HTR1A, SLC6A4
3substance abuse31.0SLC6A4
4bipolar disorder30.9SLC6A4, HTR2A
5oppositional defiant disorder30.9SLC6A2
6social phobia30.9HTR1A, MAOA, SLC6A4
7personality disorder30.7SLC6A4, MAOA, TPH1
8irritable bowel syndrome30.5TPH1, SLC6A4
9neuroleptic malignant syndrome30.5HTR1A
10agoraphobia30.4CCKBR, HTR1A, MAOA, SLC6A2
11dysthymic disorder30.4HTR2A, MAOA
12schizophrenia30.4HTR2A, SLC6A4
13eating disorder30.3HTR2A, HTR1A, SLC6A4
14alcohol dependence30.3SLC6A4, MAOA, HTR2A
15substance dependence30.2TPH1, SLC6A4
16drug dependence30.1SLC6A4, MAOA
17fibromyalgia30.1TSPO, HTR2A, SLC6A4
18antisocial personality disorder30.1HTR2A, MAOA, SLC6A4
19borderline personality disorder30.1SLC6A4, MAOA, TPH1
20chronic fatigue syndrome30.0HTR1A, MAOA, SLC6A4
21conduct disorder29.9SLC6A4, MAOA
22attention deficit-hyperactivity disorder29.8SLC6A2, SLC6A4, MAOA, HTR2A
23bulimia nervosa29.7HTR2A, MAOA, SLC6A4
24obsessive-compulsive disorder29.7TPH1, TSPO, HTR2A, HTR1A, MAOA, SLC6A4
25dementia29.7TSPO, HTR2A, HTR1A, MAOA
26mood disorder29.4TPH1, HTR2A, HTR1A, MAOA, SLC6A4, SLC6A2
27neurotic disorder29.3TPH1, HTR2A, HTR1A, MAOA, SLC6A4
28anorexia nervosa29.2SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A, TPH1
29psychotic disorder29.1TPH1, HTR2A, HTR1A, MAOA, SLC6A4
30migraine29.1TPH1, HTR2A, HTR1A, MAOA, SLC6A4
31separation anxiety disorder10.9
32blindness10.7
33hypochondriasis10.4
34alcoholic psychosis10.4SLC6A4
35bipolar i disorder10.3
36phobia, specific10.3
37mutism10.3
38phobic disorder10.3
39amnestic disorder10.3TSPO, HTR1A
40melancholia10.2MAOA
41avoidant personality disorder10.2
42post-traumatic stress disorder10.2
43hypermobility syndrome10.2
44major depressive disorder and accelerated response to antidepressant drug treatment10.2HTR1A, SLC6A4
45premature ejaculation10.2HTR1A, SLC6A4
46narcolepsy10.2
47body dysmorphic disorder10.2
48thyroiditis10.2
49temporal lobe epilepsy10.2TSPO, HTR1A
50gastrointestinal system disease10.1CCKBR, TPH1

Graphical network of the top 20 diseases related to Anxiety Disorder:



Diseases related to anxiety disorder

Symptoms for Anxiety Disorder

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Genetic Tests for Anxiety Disorder

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Genetic tests related to Anxiety Disorder:

id Genetic test Affiliating Genes
1 Anxiety22

Anatomical Context for Anxiety Disorder

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MalaCards organs/tissues related to Anxiety Disorder:

31
Heart, Testes, Brain, Cortex, Amygdala, Eye, Prefrontal cortex, Cingulate cortex, Thyroid, Liver, Lung, Ovary, Prostate, Fetal brain, Temporal lobe, Hypothalamus, Pituitary

Animal Models for Anxiety Disorder or affiliated genes

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MGI Mouse Phenotypes related to Anxiety Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8SLC6A2, SLC6A4, MAOA, HTR1A, CCKBR
2MP:00053857.3TPH1, CCKBR, HTR1A, MAOA, SLC6A4, SLC6A2
3MP:00053767.1TPH1, CCKBR, HTR1A, MAOA, SLC6A4, SLC6A2
4MP:00053866.7SLC6A2, TPH1, CCKBR, HTR2A, HTR1A, MAOA

Publications for Anxiety Disorder

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Articles related to Anxiety Disorder:

(show top 50)    (show all 1144)
idTitleAuthorsYear
1
Emotional reasoning and anxiety sensitivity: associations with social anxiety disorder in childhood. (24120086)
2014
2
Clinical experiences in conducting empirically supported treatments for generalized anxiety disorder. (24411110)
2014
3
Comorbidity of oppositional defiant disorder and anxiety disorders in preschoolers. (24444726)
2014
4
Comorbid social withdrawal (hikikomori) in outpatients with social anxiety disorder: clinical characteristics and treatment response in a case series. (21997765)
2013
5
Adult separation anxiety disorder in DSM-5. (23673209)
2013
6
Comorbidity of social anxiety disorder and antisocial personality disorder in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). (24384071)
2013
7
Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety disorder. (22130178)
2013
8
Social anxiety and social anxiety disorder. (23537485)
2013
9
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
10
Is adolescent generalized anxiety disorder a magnet for negative parental interpersonal behaviors? (23390021)
2013
11
The effect of escitalopram on metabolic parameters in patients with major depressive disorder, generalised anxiety disorder, and panic disorder: a prospective 6-month follow-up study. (23642988)
2013
12
Evaluation of the proposed social anxiety disorder specifier change for DSM-5 in a treatment-seeking sample of anxious youth. (23494954)
2013
13
Commitment to a purpose in life: An antidote to the suffering by individuals with social anxiety disorder. (23795592)
2013
14
Feasibility of exercise training for the short-term treatment of generalized anxiety disorder: a randomized controlled trial. (22116310)
2012
15
Pregabalin versus SSRIs and SNRIs in benzodiazepine-refractory outpatients with generalized anxiety disorder: a post hoc cost-effectiveness analysis in usual medical practice in Spain. (22745564)
2012
16
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
17
Panic-focused psychodynamic psychotherapy in a woman with panic disorder and generalized anxiety disorder. (23030215)
2012
18
Are children with "pure" generalized anxiety disorder impaired? A comparison with comorbid and healthy children. (22963176)
2012
19
Generalized anxiety disorder and the proposed associated symptoms criterion change for DSM-5 in a treatment-seeking sample of anxious youth. (22952043)
2012
20
A parent-child interactional model of social anxiety disorder in youth. (22116625)
2012
21
Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder. (22320999)
2012
22
Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder. (21872345)
2011
23
Association between generalized anxiety disorder and asthma morbidity. (21715294)
2011
24
Cognitive-Behavioral Therapy for Immigrants Presenting With Social Anxiety Disorder: Two Case Studies. (22844232)
2011
25
Statistical alchemy for drug treatment of generalized anxiety disorder: a commentary on the meta-analysis by Baldwin et al. [BMJ 2011;342:d1199]. (21654185)
2011
26
Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. (20439149)
2010
27
A multicenter, placebo-controlled, double-blind, randomized study of efficacy and safety of ocinaplon (DOV 273,547) in generalized anxiety disorder. (20041911)
2010
28
Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. (20123913)
2010
29
Management of generalized anxiety disorder in primary care: identifying the challenges and unmet needs. (20694114)
2010
30
Understanding behavior: generalized anxiety disorder. (20180208)
2009
31
Pharmacotherapy for social anxiety disorder: an update. (19728573)
2009
32
Panic disorder and social anxiety disorder subtypes in a caffeine challenge test. (19698996)
2009
33
How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale. (19273493)
2009
34
Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: a randomized, controlled trial. (19570931)
2009
35
Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence. (18399707)
2008
36
A preliminary study of fMRI-guided rTMS in the treatment of generalized anxiety disorder. (18572984)
2008
37
Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial. (18344738)
2008
38
Anxiety disorder comobidity in Bipolar I Disorder: relationship to depression severity and treatment outcome. (15786484)
2005
39
Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study. (15930067)
2005
40
New pharmacological treatment approaches for anxiety disorders. (16594270)
2005
41
Separation anxiety disorder. (15768687)
2005
42
The Nottingham Study of Neurotic Disorder: predictors of 12-year outcome of dysthymic, panic and generalized anxiety disorder. (15724870)
2004
43
Separation anxiety disorder: planning treatment. (10878189)
2000
44
No association between anxiety disorders and catechol-O-methyltransferase polymorphism. (9754693)
1998
45
Two cases of essential myoclonus, epilepsy, mental retardation and anxiety disorders. (9339874)
1997
46
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
47
A phase II multicenter dose-finding, efficacy and safety trial of ipsapirone in outpatients with generalized anxiety disorder. (7915845)
1994
48
5-HT1A receptor sensitivity in depression and anxiety disorders: molecular mechanisms of neuroadaption. (1498813)
1992
49
5-HT1A receptor responsivity in anxiety disorders and depression. (1763190)
1991
50
Thyroid hormones in panic disorder, panic disorder with agoraphobia, and generalized anxiety disorder. (3379028)
1988

Variations for Anxiety Disorder

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Expression for genes affiliated with Anxiety Disorder

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Search GEO for disease gene expression data for Anxiety Disorder.

Pathways for genes affiliated with Anxiety Disorder

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Pathways related to Anxiety Disorder according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SLC6A2, SLC6A4
2
Show member pathways
9.5HTR1A, HTR2A
3
Show member pathways
9.2MAOA, TPH1
4
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)36
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA36
tryptophan degradation36
glutaryl-CoA degradation36
serotonin degradation36
NAD de novo biosynthesis36
superpathway of melatonin degradation36
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde36
tryptophan utilization I36
melatonin degradation I36
9.2MAOA, TPH1
5
Show member pathways
catecholamine biosynthesis36
9.2MAOA, TPH1
6
Show member pathways
Serotonin Transporter Activity36
8.7MAOA, SLC6A4, SLC6A2
7
Show member pathways
8.6TSPO, CCKBR, HTR2A, HTR1A
8
Show member pathways
7.7SLC6A4, MAOA, HTR1A, HTR2A, TPH1
97.7SLC6A4, MAOA, HTR1A, HTR2A, TPH1
107.7TPH1, HTR2A, HTR1A, MAOA, SLC6A4

Compounds for genes affiliated with Anxiety Disorder

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 28IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Anxiety Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1p-chlorophenylalanine439.5HTR1A, SLC6A4, TPH1
2milnacipran43 49 1211.3SLC6A2, SLC6A4, HTR1A
38-hydroxy-2-(di-n-propylamino)tetralin439.3SLC6A4, HTR2A, HTR1A
4m-chlorophenylpiperazine439.2HTR2A, SLC6A4, HTR1A
5mcpp439.1HTR2A, HTR1A, SLC6A4
6selective serotonin reuptake inhibitors499.1HTR2A, HTR1A, SLC6A4
7duloxetine43 49 28 1212.0SLC6A2, HTR2A, SLC6A4
8bufotenine43 28 1211.0HTR1A, MAOA, HTR2A
95-hydroxytryptophan438.9HTR2A, HTR1A, SLC6A4, TPH1
10fenfluramine43 28 1210.9SLC6A4, HTR2A, TPH1, HTR1A
11naratriptan43 28 1210.9HTR1A, MAOA, HTR2A
12phentermine43 129.9SLC6A2, SLC6A4, MAOA
13trimipramine43 49 1210.9HTR2A, HTR1A, SLC6A2, SLC6A4
14nefazodone43 49 1210.9HTR1A, HTR2A, SLC6A2, SLC6A4
15escitalopram43 49 24 1211.9HTR1A, SLC6A2, SLC6A4, HTR2A
16venlafaxine43 49 24 1211.8SLC6A2, SLC6A4, HTR1A, HTR2A
17doxepin43 28 49 1211.8SLC6A2, HTR1A, HTR2A, SLC6A4
18carbon-11438.8SLC6A4, HTR1A, MAOA, TSPO
19nortriptyline49 43 28 1211.8SLC6A2, SLC6A4, HTR1A, HTR2A
20benzodiazepines438.8TSPO, CCKBR, MAOA
21d amphetamine438.7SLC6A4, SLC6A2, MAOA, TSPO
22p-chloroamphetamine438.7SLC6A2, SLC6A4, MAOA, HTR1A
23pseudoephedrine43 24 1210.7SLC6A2, SLC6A4, MAOA
24sertraline43 28 49 24 1212.7HTR1A, SLC6A2, SLC6A4, MAOA
25raclopride43 289.7HTR2A, CCKBR, HTR1A
26homovanillic acid43 249.6TPH1, MAOA, SLC6A2, SLC6A4
275-hydroxyindoleacetic acid43 249.6TPH1, MAOA, SLC6A4, SLC6A2
28mptp438.6TSPO, MAOA, SLC6A2, SLC6A4
29minaprine43 129.6SLC6A4, MAOA, HTR2A
30methamphetamine43 49 1210.6MAOA, TPH1, SLC6A2, SLC6A4
31Serotonin248.5HTR1A, MAOA, SLC6A4, HTR2A
32mdma438.3TPH1, HTR1A, MAOA, SLC6A4, SLC6A2
33gaba438.2SLC6A2, MAOA, TPH1, TSPO, SLC6A4
34amphetamine43 49 1210.1CCKBR, MAOA, SLC6A4, TPH1, SLC6A2
35mianserin43 28 1210.1SLC6A2, HTR1A, MAOA, HTR2A, SLC6A4
36amitriptyline43 28 49 1211.1SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A
37desipramine43 49 1210.1SLC6A2, HTR2A, HTR1A, MAOA, SLC6A4
38imipramine43 28 49 24 1212.1HTR2A, SLC6A2, SLC6A4, MAOA, HTR1A
39haloperidol43 49 28 2 1212.1TSPO, CCKBR, HTR2A, HTR1A, SLC6A4, SLC6A2
40nicotine43 28 49 1210.8TPH1, TSPO, MAOA, CCKBR, SLC6A2, SLC6A4
41nmda43 288.8MAOA, SLC6A4, HTR1A, CCKBR, TSPO
42clomipramine43 49 129.8TSPO, HTR2A, HTR1A, MAOA, SLC6A4, SLC6A2
43paroxetine43 49 28 1210.7SLC6A2, HTR2A, HTR1A, SLC6A4, MAOA, TPH1
44maoa437.7SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A, TPH1
45fluoxetine43 49 28 1210.7HTR2A, TPH1, SLC6A2, MAOA, HTR1A, SLC6A4
46citalopram43 49 24 1210.7TPH1, HTR1A, MAOA, SLC6A4, SLC6A2, HTR2A
475-hydroxytryptamine437.4TPH1, TSPO, HTR2A, HTR1A, MAOA, SLC6A2
48fluvoxamine43 49 129.4TPH1, TSPO, HTR1A, MAOA, SLC6A4, SLC6A2
49norepinephrine43 24 129.3SLC6A2, SLC6A4, MAOA, HTR1A, HTR2A, TSPO
50dopamine43 28 24 129.8CCKBR, TSPO, SLC6A2, SLC6A4, MAOA, TPH1

GO Terms for genes affiliated with Anxiety Disorder

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Cellular components related to Anxiety Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:00430059.1SLC6A2, SLC6A4, TPH1
2integral component of plasma membraneGO:00058877.7SLC6A2, SLC6A4, HTR1A, HTR2A, CCKBR

Biological processes related to Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:00468839.7HTR1A, HTR2A
2monoamine transportGO:00158449.7SLC6A2, SLC6A4
3vasoconstrictionGO:00423109.6SLC6A4, HTR1A
4serotonin receptor signaling pathwayGO:00072109.6HTR1A, HTR2A
5regulation of behaviorGO:00507959.6HTR2A, HTR1A
6circadian rhythmGO:00076239.4TPH1, SLC6A4
7cell proliferationGO:00082839.2HTR1A, CCKBR, TSPO
8memoryGO:00076139.0SLC6A4, HTR2A
9positive regulation of cell proliferationGO:00082849.0HTR1A, HTR2A, CCKBR
10response to drugGO:00424938.8SLC6A2, SLC6A4, HTR2A, TSPO
11synaptic transmissionGO:00072688.4TSPO, HTR2A, MAOA, SLC6A2

Molecular functions related to Anxiety Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:00049939.5HTR1A, HTR2A
2monoamine transmembrane transporter activityGO:00085049.2SLC6A2, SLC6A4

Products for genes affiliated with Anxiety Disorder

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Sources for Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet