Aliases & Classifications for Aortic Aneurysm

Aliases & Descriptions for Aortic Aneurysm:

Name: Aortic Aneurysm 12 29 41 3 42 14 69
Thoracoabdominal Aortic Aneurysm, Ruptured 12 69
Ruptured Abdominal Aortic Aneurysm 12 69
Ruptured Thoracic Aortic Aneurysm 12 69
Aortic Rupture 42 69
Aortic Aneurysm Without Mention of Rupture Nos 69
Aortic Aneurysm of Unspecified Site, Ruptured 12
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Abdominal Aortic Aneurysm, Ruptured 12
Thoracic Aortic Aneurysm, Ruptured 12
Ruptured Aortic Aneurysm Nos 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 69
Ruptured Aortic Aneurysm 12

Classifications:



Summaries for Aortic Aneurysm

MedlinePlus : 41 an aneurysm is a bulge or "ballooning" in the wall of an artery. arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. if an aneurysm grows large, it can burst and cause dangerous bleeding or even death. most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. there are two types of aortic aneurysm: thoracic aortic aneurysms (taa) - these occur in the part of the aorta running through the chest abdominal aortic aneurysms (aaa) - these occur in the part of the aorta running through the abdomen most aneurysms are found during tests done for other reasons. some people are at high risk for aneurysms. it is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. doctors use imaging tests to find aneurysms. medicines and surgery are the two main treatments. nih: national heart, lung, and blood institute

MalaCards based summary : Aortic Aneurysm, also known as thoracoabdominal aortic aneurysm, ruptured, is related to aortic aneurysm, familial thoracic 6 and abdominal aortic aneurysm, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Aortic Aneurysm is ACTA2 (Actin, Alpha 2, Smooth Muscle, Aorta), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Atenolol and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and lung, and related phenotypes are cardiovascular system and growth/size/body region

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia : 71 An aortic aneurysm is an enlargement (dilation) of the aorta to greater than 1.5 times normal size. They... more...

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
id Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial thoracic 6 33.3 MMP9 SMAD3 TGFBR1 TIMP1
2 abdominal aortic aneurysm 12.6
3 thoracic aortic aneurysm 12.6
4 familial thoracic aortic aneurysm and dissection 12.4
5 aortic aneurysm, familial thoracic 1 12.4
6 familial abdominal aortic aneurysm 12.4
7 aortic aneurysm, familial thoracic 4 12.3
8 aortic aneurysm, familial thoracic 7 12.2
9 aortic aneurysm, familial thoracic 10 12.2
10 aortic aneurysm, familial thoracic 9 12.2
11 aortic aneurysm, familial thoracic 11 12.2
12 aortic aneurysm, familial thoracic 8 12.2
13 thoracic aortic aneurysms and aortic dissections 12.1
14 acta2-related thoracic aortic aneurysms and aortic dissections 12.0
15 myh11-related thoracic aortic aneurysms and aortic dissections 12.0
16 loeys-dietz syndrome 12.0
17 prkg1-related thoracic aortic aneurysms and aortic dissections 11.9
18 mfap5-related thoracic aortic aneurysms and aortic dissections 11.9
19 mylk-related thoracic aortic aneurysms and aortic dissections 11.9
20 aortic aneurysm, familial thoracic 2 11.9
21 aortic aneurysm, familial abdominal, 4 11.9
22 marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections 11.9
23 fbn1-related thoracic aortic aneurysms and aortic dissections 11.9
24 tgfbr1-related thoracic aortic aneurysms and aortic dissections 11.9
25 tgfbr2-related thoracic aortic aneurysms and aortic dissections 11.9
26 smad2-related thoracic aortic aneurysms and aortic dissections 11.9
27 smad3-related thoracic aortic aneurysms and aortic dissections 11.9
28 aneurysm 11.8
29 loeys-dietz syndrome 1 11.7
30 loeys-dietz syndrome 2 11.6
31 marfan syndrome 11.3
32 multisystemic smooth muscle dysfunction syndrome 11.1
33 cutis laxa, ad 11.0
34 loeys-dietz syndrome 4 10.9
35 cutis laxa, autosomal dominant 3 10.9
36 cutis laxa, autosomal recessive, type ib 10.9
37 loeys-dietz syndrome 5 10.9
38 cutis laxa, autosomal dominant 2 10.9
39 loeys-dietz syndrome 3 10.9
40 horseshoe kidney 10.4
41 ischemia 10.3
42 linear focal dermal elastosis 10.3 ELN FBN1
43 acute sensory ataxic neuropathy 10.3 ELN FBN1
44 acute pure sensory neuropathy 10.3 ELN FBN1
45 megalencephalic leukoencephalopathy with subcortical cysts 2b, remitting, with or without mental retardation 10.3 AAT1 MYH11
46 facio skeletal genital syndrome rippberger type 10.3 MMP2 MMP9
47 olecranon bursitis 10.3 ELN FBN1 LOX
48 adult-onset distal myopathy due to vcp mutation 10.3 ELN FBN1 MMP9
49 intellectual developmental disorder with persistence of fetal hemoglobin 10.3 SMAD3 TGFBR1 TGFBR2
50 tinea profunda 10.2 ELN MMP2 MMP9

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Cardiac Arrest Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Left Ventricular Outflow Tract Obstruction Mesenteric Artery Ischemia
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Aortic Aneurysm:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ACTA2 APOE COL3A1 FBN1 IL6 KLF15
2 growth/size/body region MP:0005378 10.37 AAAS APOE COL3A1 FBN1 IL6 KLF15
3 homeostasis/metabolism MP:0005376 10.36 SMAD3 TGFBR1 TGFBR2 AAAS APOE COL3A1
4 cellular MP:0005384 10.26 TGFBR2 AAAS APOE COL3A1 FBN1 IL6
5 immune system MP:0005387 10.25 APOE COL3A1 FBN1 IL6 KLF15 MFAP5
6 hematopoietic system MP:0005397 10.22 APOE FBN1 IL6 KLF15 MFAP5 MMP2
7 digestive/alimentary MP:0005381 10.21 AAAS APOE COL3A1 IL6 MMP9 MYH11
8 mortality/aging MP:0010768 10.21 APOE COL3A1 FBN1 IL6 KLF15 LOX
9 muscle MP:0005369 10.13 MMP9 MYH11 MYLK TGFBR1 TGFBR2 ACTA2
10 integument MP:0010771 10.1 IL6 LOX APOE COL3A1 FBN1 MMP13
11 adipose tissue MP:0005375 10.02 APOE COL3A1 FBN1 IL6 KLF15 TGFBR2
12 neoplasm MP:0002006 9.8 IL6 MMP2 MMP9 SMAD3 TGFBR1 TGFBR2
13 renal/urinary system MP:0005367 9.76 SMAD3 APOE FBN1 IL6 KLF15 MMP9
14 respiratory system MP:0005388 9.7 APOE COL3A1 FBN1 IL6 LOX MMP2
15 skeleton MP:0005390 9.4 TGFBR1 TGFBR2 TIMP1 APOE FBN1 IL6

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 248)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atenolol Approved Phase 4,Phase 2 29122-68-7 2249
2
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
3
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
4
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
5
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
9
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
10
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
11
Levobupivacaine Approved Phase 4 27262-47-1 92253
12
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
13
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
14
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
15
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
16
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
17
Eplerenone Approved Phase 4 107724-20-9 150310 443872
18
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
19
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
20
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
21
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
22
Clevidipine Approved Phase 4 167221-71-8
23 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Adrenergic Antagonists Phase 4,Phase 2,Phase 1,Early Phase 1
25 Adrenergic beta-1 Receptor Antagonists Phase 4,Phase 2,Early Phase 1
26 Adrenergic beta-Antagonists Phase 4,Phase 2,Early Phase 1
27
Angiotensin II Phase 4,Phase 3,Phase 2 68521-88-0, 11128-99-7 65143 172198
28 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3,Phase 2
29 Angiotensin Receptor Antagonists Phase 4,Phase 3,Phase 2
30 Angiotensinogen Phase 4,Phase 3,Phase 2
31 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2
32 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
33 Autonomic Agents Phase 4,Phase 2,Early Phase 1
34 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Early Phase 1
36 Sympatholytics Phase 4,Phase 2,Early Phase 1
37 Anticonvulsants Phase 4
38 Carbonic Anhydrase Inhibitors Phase 4
39 diuretics Phase 4
40 Natriuretic Agents Phase 4,Phase 3
41 Antifibrinolytic Agents Phase 4,Phase 3
42 Coagulants Phase 4,Phase 3
43 Hemostatics Phase 4,Phase 3
44 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
45 Anti-Infective Agents Phase 4,Phase 3,Phase 2
46 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
47 Antimetabolites Phase 4,Phase 3,Phase 2
48 Atorvastatin Calcium Phase 4,Phase 3,Phase 2 134523-03-8
49 Calcium, Dietary Phase 4,Phase 3,Phase 2
50 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 528)
id Name Status NCT ID Phase
1 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
2 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Unknown status NCT01904981 Phase 4
3 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4
4 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4
5 Tranexamic Acid in Major Vascular Surgery Unknown status NCT02335359 Phase 4
6 Prospective, Multicenter Study of the Second Generation Antimicrobial Graft in the Abdominal Position Unknown status NCT00824109 Phase 4
7 A Morbidity-Mortality and Remodeling Study With Valsartan Unknown status NCT00133328 Phase 4
8 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
9 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
10 Endovascular Repair of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
11 Post-Approval Trial of the Talent™ Abdominal Stent Graft to Treat Aortic Aneurysms Completed NCT00816062 Phase 4
12 GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
13 Statin Use in Abdominal Aortic Aneurysm Repair Completed NCT01062802 Phase 4
14 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4
15 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
16 Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair Completed NCT02677532 Phase 4
17 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4
18 The Pharmacokinetics of Opioids and Sedative/Hypnotics During Selective Cerebral Perfusion Completed NCT00494598 Phase 4
19 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
20 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4
21 Atorvastatin in Perioperative Vascular Surgery - Pilot Study Completed NCT00610545 Phase 4
22 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From Abdominal Aorta Surgery Completed NCT00819936 Phase 4
23 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
24 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4
25 Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier Completed NCT00878371 Phase 4
26 Add-on Effects of Valsartan on Morbi- Mortality (KYOTO HEART Study) Completed NCT00149227 Phase 4
27 Eplerenone in the Management of Abdominal Aortic Aneurysms Recruiting NCT02345590 Phase 4
28 Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Recruiting NCT02107170 Phase 4
29 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
30 AAA Registry: Clinical Outcomes of Highly Angulated anatomY Treated With the Aorfix™ Stent Graft Recruiting NCT02480595 Phase 4
31 Bloodtranfusions After Aortic Surgery Recruiting NCT02299947 Phase 4
32 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Active, not recruiting NCT01683084 Phase 4
33 Endurant Stent Graft System Post Approval Study Active, not recruiting NCT01379222 Phase 4
34 CUstodiol Versus RInger: whaT Is the Best Agent? Active, not recruiting NCT02327611 Phase 4
35 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy Active, not recruiting NCT02345603 Phase 4
36 Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices Enrolling by invitation NCT02407457 Phase 4
37 Effect of Intraoperative Dexmedetomidine on Lung Not yet recruiting NCT02678728 Phase 4
38 Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Terminated NCT00118573 Phase 4
39 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4
40 The (PIVOTAL) Study Terminated NCT00444821 Phase 4
41 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
42 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4
43 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
44 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
45 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
46 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3
47 The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure Unknown status NCT00110201 Phase 3
48 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
49 Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients Unknown status NCT00125463 Phase 3
50 Methotrexate as a Steroid-sparing Agent in Idiopathic Retroperitoneal Fibrosis: a Randomised, Multicenter Trial Unknown status NCT01240850 Phase 3

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

id Genetic test Affiliating Genes
1 Aortic Aneurysm 29

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

39
Kidney, Heart, Lung, Spinal Cord, Testes, Smooth Muscle, Colon

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 3077)
id Title Authors Year
1
Mechanical behavior of the abdominal aortic aneurysm assessed by biaxial tests in the rat xenograft model. ( 28527353 )
2017
2
Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial. ( 28049491 )
2017
3
A New Mouse Model for Introduction of Aortic Aneurysm by Implantation of Deoxycorticosterone Acetate Pellets or Aldosterone Infusion in the Presence of High Salt. ( 28500602 )
2017
4
Bile-ated Cell Death Decreases Aortic Aneurysm Formation. ( 28089083 )
2017
5
Recombinant adeno-associated virus vector carrying the thrombomodulin lectin-like domain for the treatment of abdominal aortic aneurysm. ( 28525804 )
2017
6
Proximal Aortic Neck Progression: Before and After Abdominal Aortic Aneurysm Treatment. ( 28523269 )
2017
7
Lifestyle and Risk of Screening-Detected Abdominal Aortic Aneurysm in Men. ( 28490522 )
2017
8
Mild aerobic exercise blocks elastin fiber fragmentation and aortic dilatation in a mouse model of Marfan syndrome associated aortic aneurysm. ( 28385916 )
2017
9
Atherosclerotic vascular diseases have really the same risk factors? Comparison between large abdominal aortic aneurysm and obstructive non-coronary arterial disease. ( 28509621 )
2017
10
Simple Identification of the Adamkiewicz Artery in Extended Thoracoabdominal Aortic Aneurysm Repair. ( 28528073 )
2017
11
Predicting the Need for Intra-operative Large Volume Blood Transfusions During Thoraco-abdominal Aortic Aneurysm Repair. ( 28089084 )
2017
12
Experiences of the screening process and the diagnosis abdominal aortic aneurysm among 65-year-old men from invitation to a 1-year surveillance. ( 28527730 )
2017
13
The Consequences of Real Life Practice of Early Abdominal Aortic Aneurysm Repair: A Cost-Benefit Analysis. ( 28506561 )
2017
14
Rupture of ascending aortic aneurysm in to the pulmonary artery: rare presentation with grave prognosis. ( 28062566 )
2017
15
Definitive Endovascular Repair of a Brucellar Descending Thoracic Aortic Aneurysm. ( 28513124 )
2017
16
Reoperation rates after open and endovascular abdominal aortic aneurysm repairs. ( 28073669 )
2017
17
The effects of preoperative cardiology consultation prior to elective abdominal aortic aneurysm repair on patient morbidity. ( 28059000 )
2017
18
Late Presentation of Aortic Aneurysm and Dissection Following Cardiac Catheterization. ( 28515825 )
2017
19
Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with abdominal aortic aneurysm. ( 28079254 )
2017
20
Translational Relevance and Recent Advances of Animal Models of Abdominal Aortic Aneurysm. ( 28062500 )
2017
21
Update on Screening for Abdominal Aortic Aneurysm. ( 28526395 )
2017
22
Contained ruptured abdominal aortic aneurysm presenting as cauda equina syndrome. ( 28062419 )
2017
23
Correction to: Diverse Requirements for Efficient Population Screening for Abdominal Aortic Aneurysm: From Program Management to Maintaining Skills in Open Repair. ( 28069719 )
2017
24
Transapical aortic perfusion using a deep hypothermic procedure to prevent dissecting lung injury during re-do thoracoabdominal aortic aneurysm surgery. ( 28526092 )
2017
25
Endovascular repair of a short neck abdominal aortic aneurysm with a physician-modified Vascutek Anaconda stent-graft. ( 28495541 )
2017
26
Infrarenal Infected Aortic Aneurysm Caused by Streptococcus pyogenes. ( 28503338 )
2017
27
Giant Thoracic Aortic Aneurysm Manifested as Dysphagia and Dyspnea. ( 28007285 )
2017
28
Reporting individual surgeon outcomes does not lead to risk aversion in abdominal aortic aneurysm surgery. ( 28071950 )
2017
29
Under-Utilization of Routine Ultrasound Surveillance after Endovascular Aortic Aneurysm Repair. ( 28501663 )
2017
30
Double-lumen atherosclerotic abdominal aortic aneurysm. ( 28010862 )
2017
31
Non-visualized aorta in abdominal aortic aneurysm screening: Screening outcomes and the influence of subject and programme characteristics. ( 28077001 )
2017
32
Pseudoachalasia Secondary to Thoracic Aortic Aneurysm. ( 28528055 )
2017
33
Percutaneous Septectomy in Chronic Dissection with Abdominal Aortic Aneurysm Creates Uniluminal Neck for EVAR. ( 28493108 )
2017
34
Predictors Associated With Increased Prevalence of Abdominal Aortic Aneurysm in Chinese Patients with Atherosclerotic Risk Factors. ( 28527818 )
2017
35
Prospective Study of Postoperative Glycemic Control with a Standardized Insulin Infusion Protocol after Infrainguinal Bypass and Open Abdominal Aortic Aneurysm Repair. ( 28502888 )
2017
36
von Willebrand Factor and Prekallikrein in Plasma Are Associated With Thrombus Volume in Abdominal Aortic Aneurysms. ( 27581227 )
2016
37
Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissection. ( 27534720 )
2016
38
'In-stock' fenestrated stent graft for the urgent repair of an abdominal aortic aneurysm. ( 27207986 )
2016
39
Emergency Endovascular interventions for ruptured descending Thoracic Aortic Aneurysm. ( 27671448 )
2016
40
Massive Hemoptysis From an Aortobronchial Fistula Secondary to BCG-Related Mycotic Thoracic Aortic Aneurysm. ( 26694276 )
2016
41
Hybrid two-stage repair of thoracoabdominal aortic aneurysm. ( 27188444 )
2016
42
Extensive aortic aneurysm associated with neonatal lupus erythematosus. ( 27212867 )
2016
43
The genetics and pathogenesis of thoracic aortic aneurysm disorder and dissections. ( 26662674 )
2016
44
Outcomes of type II endoleaks after endovascular abdominal aortic aneurysm (AAA) repair: a single-center, retrospective study. ( 27179957 )
2016
45
Outcome of the Swedish Nationwide Abdominal Aortic Aneurysm Screening Program. ( 27630132 )
2016
46
Factors that affect cost and clinical outcome of endovascular aortic repair for abdominal aortic aneurysm. ( 28034587 )
2016
47
Fluoroscopic-Guided Lumbar Spinal Drain Insertion for Thoracic Aortic Aneurysm Surgery. ( 28002169 )
2016
48
Tolosa-Hunt syndrome and comorbidity of obsessive compulsive disorder and aortic aneurysm. ( 27872048 )
2016
49
Thoraco-abdominal aortic aneurysm rupture secondary to lymphocytic lymphoma. ( 27659154 )
2016
50
Gluteal Compartment Syndrome Following Abdominal Aortic Aneurysm Treatment: Case Report and Review of the Literature. ( 27581114 )
2016

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh37 Chromosome 15, 48712949: 48712949

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 47)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 ACTA2 COL3A1 ELN FBN1 IL6 MYH11
2
Show member pathways
13.72 ACTA2 IL6 MMP13 MMP2 MMP9 SMAD3
3
Show member pathways
13.28 ACTA2 IL6 MYH11 MYLK SMAD3 TGFBR1
4
Show member pathways
13.25 ACTA2 COL3A1 ELN FBN1 MMP13 MMP2
5
Show member pathways
13.04 ACTA2 COL3A1 ELN FBN1 IL6 TGFBR1
6
Show member pathways
12.82 COL3A1 ELN LOX MMP13 MMP9
7 12.61 IL6 MMP2 MMP9 SMAD3 TGFBR1 TGFBR2
8
Show member pathways
12.55 MMP2 MMP9 SMAD3 TGFBR1 TGFBR2
9 12.4 IL6 SMAD3 TGFBR1 TGFBR2
10 12.08 ACTA2 MYLK SMAD3 TGFBR1
11
Show member pathways
12.08 IL6 SMAD3 TGFBR1 TGFBR2
12
Show member pathways
12.02 IL6 MMP2 SMAD3 TGFBR1 TGFBR2
13 12.02 IL6 MMP2 MMP9 SMAD3 TGFBR1 TGFBR2
14 11.97 IL6 MMP2 MMP9 TIMP1
15
Show member pathways
11.93 COL3A1 ELN FBN1 LOX MFAP5 MMP13
16
Show member pathways
11.9 IL6 SMAD3 TGFBR1 TGFBR2
17 11.88 SMAD3 TGFBR1 TGFBR2
18
Show member pathways
11.87 MMP13 MMP2 MMP9 TIMP1
19
Show member pathways
11.84 IL6 SMAD3 TGFBR1 TGFBR2
20 11.8 MMP2 MMP9 TGFBR1 TIMP1
21 11.79 SMAD3 TGFBR1 TGFBR2
22 11.72 SMAD3 TGFBR1 TGFBR2
23 11.72 SMAD3 TGFBR1 TGFBR2
24
Show member pathways
11.71 LOX SMAD3 TGFBR1 TGFBR2
25
Show member pathways
11.7 SMAD3 TGFBR1 TGFBR2
26 11.67 IL6 MMP2 MMP9
27
Show member pathways
11.67 ELN FBN1 LOX MFAP5
28
Show member pathways
11.65 IL6 MMP2 MMP9
29 11.63 ACTA2 MMP2 SMAD3 TGFBR1 TGFBR2
30 11.61 SMAD3 TGFBR1 TGFBR2
31 11.6 MMP13 MMP2 MMP9 SMAD3
32 11.55 IL6 SMAD3 TGFBR1
33 11.55 SMAD3 TGFBR1 TGFBR2
34 11.53 MMP13 TGFBR1 TGFBR2
35 11.52 IL6 MMP2 MMP9
36
Show member pathways
11.45 SMAD3 TGFBR1 TGFBR2
37 11.45 ELN IL6 MMP2 MMP9 TIMP1
38 11.44 MMP13 SMAD3 TGFBR1
39 11.43 COL3A1 IL6 MMP2 SMAD3 TGFBR1 TGFBR2
40 11.39 APOE IL6 SMAD3 TGFBR1
41 11.37 ACTA2 MYH11 MYLK
42 11.35 APOE MMP2 MMP9
43 11.34 COL3A1 MMP13 MMP2 MMP9 TIMP1
44 11.33 IL6 MMP2 MMP9
45 11.25 SMAD3 TGFBR1 TGFBR2
46 11.1 FBN1 SMAD3 TGFBR1 TGFBR2
47 11.05 SMAD3 TGFBR1 TGFBR2

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 ACTA2 APOE COL3A1 FBN1 IL6 LOX
2 endoplasmic reticulum lumen GO:0005788 9.77 APOE COL3A1 FBN1 IL6 TIMP1
3 collagen trimer GO:0005581 9.62 COL3A1 LOX MMP13 TIMP1
4 extracellular matrix GO:0031012 9.5 APOE COL3A1 FBN1 MMP13 MMP2 MMP9
5 microfibril GO:0001527 9.43 FBN1 MFAP5
6 transforming growth factor beta receptor complex GO:0070022 9.4 TGFBR1 TGFBR2
7 proteinaceous extracellular matrix GO:0005578 9.28 COL3A1 ELN FBN1 LOX MFAP5 MMP13
8 extracellular region GO:0005576 10 APOE COL3A1 ELN FBN1 IL6 LOX

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.91 APOE KLF15 TGFBR1 TGFBR2
2 aging GO:0007568 9.86 COL3A1 IL6 TGFBR2 TIMP1
3 positive regulation of cell migration GO:0030335 9.85 MMP9 MYLK SMAD3 TGFBR1
4 heart development GO:0007507 9.83 COL3A1 FBN1 LOX TGFBR1 TGFBR2
5 cartilage development GO:0051216 9.8 MMP13 TGFBR2 TIMP1
6 response to mechanical stimulus GO:0009612 9.79 COL3A1 IL6 TGFBR2
7 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.77 SMAD3 TGFBR1 TGFBR2
8 response to cytokine GO:0034097 9.77 COL3A1 IL6 TIMP1
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.76 FBN1 SMAD3 TGFBR1
10 cellular protein metabolic process GO:0044267 9.73 APOE FBN1 IL6 MMP13 MMP2 TIMP1
11 skeletal system development GO:0001501 9.72 COL3A1 FBN1 MMP9 SMAD3 TGFBR1
12 transforming growth factor beta receptor signaling pathway GO:0007179 9.71 COL3A1 SMAD3 TGFBR1 TGFBR2
13 embryo implantation GO:0007566 9.7 MMP2 MMP9 TGFBR2
14 collagen fibril organization GO:0030199 9.69 COL3A1 LOX TGFBR1
15 positive regulation of epithelial to mesenchymal transition GO:0010718 9.67 SMAD3 TGFBR1 TGFBR2
16 collagen catabolic process GO:0030574 9.67 COL3A1 MMP13 MMP2 MMP9
17 embryonic cranial skeleton morphogenesis GO:0048701 9.65 SMAD3 TGFBR1 TGFBR2
18 activin receptor signaling pathway GO:0032924 9.64 SMAD3 TGFBR1
19 pathway-restricted SMAD protein phosphorylation GO:0060389 9.64 TGFBR1 TGFBR2
20 supramolecular fiber organization GO:0097435 9.63 COL3A1 MFAP5
21 extracellular matrix organization GO:0030198 9.63 COL3A1 ELN FBN1 LOX MFAP5 MMP9
22 response to cholesterol GO:0070723 9.62 TGFBR1 TGFBR2
23 elastic fiber assembly GO:0048251 9.58 LOX MYH11
24 growth plate cartilage development GO:0003417 9.57 MMP13 TGFBR2
25 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.54 TGFBR1 TGFBR2
26 aorta smooth muscle tissue morphogenesis GO:0060414 9.46 COL3A1 MYLK
27 extracellular matrix disassembly GO:0022617 9.43 ELN FBN1 MMP13 MMP2 MMP9 TIMP1
28 wound healing GO:0042060 9.17 COL3A1 IL6 LOX SMAD3 TGFBR1 TGFBR2
29 negative regulation of apoptotic process GO:0043066 10.03 IL6 MMP9 SMAD3 TGFBR1 TIMP1

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 collagen binding GO:0005518 9.43 MMP13 MMP9 SMAD3
2 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.32 TGFBR1 TGFBR2
3 extracellular matrix structural constituent GO:0005201 9.26 COL3A1 ELN FBN1 MFAP5
4 transforming growth factor beta-activated receptor activity GO:0005024 9.16 TGFBR1 TGFBR2
5 SMAD binding GO:0046332 8.92 COL3A1 SMAD3 TGFBR1 TGFBR2
6 metal ion binding GO:0046872 10.11 COL3A1 KLF15 LOX MMP13 MMP2 MMP9

Sources for Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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