MCID: ART016
MIFTS: 62

Aortic Aneurysm malady

Summaries for Aortic Aneurysm

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 An aneurysm is a bulge or "ballooning" in the wall of an artery. arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. if an aneurysm grows large, it can burst and cause dangerous bleeding or even death. most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. there are two types of aortic aneurysm: thoracic aortic aneurysms - these occur in the part of the aorta running through the chest abdominal aortic aneurysms - these occur in the part of the aorta running through the abdomen most aneurysms are found during tests done for other reasons. some people are at high risk for aneurysms. it is important for them to get screening, because aneurysms can develop and become large before causing any symptoms screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. doctors use imaging tests to find aneurysms. medicines and surgery are the two main treatments. nih: national heart, lung, and blood institute

MalaCards: Aortic Aneurysm is related to abdominal aortic aneurysm and thoracic aortic aneurysm. An important gene associated with Aortic Aneurysm is ACTA2 (actin, alpha 2, smooth muscle, aorta), and among its related pathways are Integrin Pathway and Rho Family GTPases. The drug trimethaphan camsylate and the compounds serine and vegf have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are homeostasis/metabolism and immune system.

CDC:3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia:64 An aortic aneurysm is a general term for an enlargement (dilation) of the aorta to greater than 1.5... more...

Aliases & Classifications for Aortic Aneurysm

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

aortic aneurysm 8 10 34 61


External Ids:

Disease Ontology8 DOID:3627
NCIt40 C26697
MeSH35 D001014

Related Diseases for Aortic Aneurysm

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 307)
idRelated DiseaseScoreTop Affiliating Genes
1abdominal aortic aneurysm32.3MMP9
2thoracic aortic aneurysm32.0TGFBR2, ELN, MMP1, MMP2, MYH11, FBN1
3dissecting aortic aneurysm31.7ELN
4aneurysm disease31.5FBN1, COL3A1, MMP2, MMP8, MMP12, MMP9
5aortic disease31.5FBN1, ELN
6marfan syndrome31.2TGFBR1, TGFBR2, ELN, FBN1, COL3A1
7atherosclerosis30.7ELANE, MMP8, ELN, MMP9, MMP1, MMP12
8loeys-dietz syndrome30.7TGFBR1, TGFBR2, ACTA2, FBN1, COL3A1
9vascular disease30.5ELN, ELANE, TGFBR1, MMP9
10coronary artery disease,30.5MMP9, MMP12, FBN1, COL3A1
11intracranial aneurysm30.5ELN, COL3A1, ELANE
12pulmonary disease, chronic obstructive30.5MMP9, MMP12
13thoracic aortic aneurysms and aortic dissections30.4MYH11, ACTA2, TGFBR2, TGFBR1
14aortic valve stenosis30.4ELN
15arteriosclerosis30.4ELN
16osteoarthritis30.2MMP12, MMP2, MMP9, MMP8, MMP1
17cutis laxa30.2FBN1, ELANE, ELN
18acute myocardial infarction30.2MMP8, MMP9
19supravalvular aortic stenosis30.2ELN, FBN1
20colorectal cancer30.2MMP1, MMP2, MMP9, TGFBR2
21squamous cell carcinoma30.0MMP9, MMP2, TGFBR1, MMP12, MMP1, TGFBR2
22arthritis30.0MMP1, MMP2, MMP8, FBN1, MMP12, MMP9
23exfoliation syndrome30.0FBN1, ELN, MMP1
24bladder carcinoma30.0MMP2, TGFBR1, MMP9, MMP12
25coronary heart disease30.0FBN1, MMP8
26ehlers-danlos syndrome type iv30.0COL3A1, ELN
27mitral valve prolapse30.0FBN1
28pseudoxanthoma elasticum30.0FBN1, ELN
29acute pancreatitis30.0ELANE
30transitional cell carcinoma30.0TGFBR2, TGFBR1, MMP9
31ruptured abdominal aortic aneurysm11.3
32horseshoe kidney10.9
33familial thoracic aortic aneurysm and dissection10.7
34coronary aneurysm10.7
35spinal cord ischemia10.7
36aortitis10.7
37aortic coarctation10.7
38heart aneurysm10.5
39ruptured thoracoabdominal aortic aneurysm10.5
40coronary artery aneurysm10.5
41aortic atherosclerosis10.5
42retroperitoneal fibrosis10.5
43dysphagia10.5
44subclavian artery aneurysm10.4
45superior mesenteric artery syndrome10.4
46chylous ascites10.4
47systemic lupus erythematosus10.4
48ehlers–danlos syndrome10.4
49aortic aneurysm, familial thoracic 410.4
50cardiac rupture10.4

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to aortic aneurysm

Clinical Features for Aortic Aneurysm

Drugs & Therapeutics for Aortic Aneurysm

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aortic Aneurysm

Drug clinical trials:

Search ClinicalTrials for Aortic Aneurysm

Search NIH Clinical Center for Aortic Aneurysm

Search CenterWatch for Aortic Aneurysm

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Aortic Aneurysm

Anatomical Context for Aortic Aneurysm

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Aortic Aneurysm:

33
Liver, Spinal cord, Brain, Kidney, Lung, Whole blood, Heart, Smooth muscle, Small intestine, Colon, Thyroid, Myeloid, Monocytes, T cells, B cells, Endothelial, Trachea, Pituitary

Animal Models for Aortic Aneurysm or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Aortic Aneurysm

Sources:
51PubMed
See all sources

Articles related to Aortic Aneurysm:

(show top 50)    (show all 2881)
idTitleAuthorsYear
1
Preliminary biomarkers for identification of human ascending thoracic aortic aneurysm. (24231657)
2013
2
Type B aortic dissection after standard endovascular repair of abdominal aortic aneurysm. (23667216)
2013
3
In situ repair of a mycotic suprarenal aortic aneurysm using a cryopreserved aortic homograft and visceral debranching in a patient with spondylodiscitis and left psoas muscle abscess. (23903708)
2013
4
Extra-aortic mycotic aneurysm due to group A Streptococcus after pharyngitis. (23761143)
2013
5
Repair of thoracic aortic aneurysm due to noninfectious aortitis. (22309320)
2012
6
Aortic coarctation misdiagnosed as a descending thoracic aorta aneurysm. (22480937)
2012
7
Management of a parturient with a thoracic aortic aneurysm. (21441805)
2011
8
Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm. (21436157)
2011
9
New technique for the preservation of the left common carotid artery in zone 2a endovascular repair of thoracic aortic aneurysm. (20425111)
2011
10
Ruptured abdominal aortic aneurysm presenting as painless testicular ecchymosis: the scrotal sign of Bryant revisited. (18614326)
2011
11
Pulmonary large cell carcinoma mimicking an infected thoracoabdominal aortic aneurysm. (21847044)
2011
12
Superior nationwide outcomes of endovascular versus open repair for isolated descending thoracic aortic aneurysm in 11,669 patients. (20951252)
2010
13
Delayed dysphagia after endovascular repair of thoracic aortic aneurysm. (21035721)
2010
14
A systematic review of studies examining inflammation associated cytokines in human abdominal aortic aneurysm samples. (19729799)
2009
15
Spontaneous spinal cord infarction secondary to embolism from an aortic aneurysm mimicking as cauda equina due to disc prolapse: a case report. (19829969)
2009
16
New case of an infrarenal abdominal aortic aneurysm associated with horseshoe kidney. (20096188)
2009
17
Aortic decision-making in the Loeys-Dietz syndrome: aortic root aneurysm and a normal-caliber ascending aorta and aortic arch. (19619806)
2009
18
Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. (19136615)
2009
19
Abdominal aortic aneurysm]. (19609772)
2009
20
Profunda femoris as an access site vessel for a hybrid approach to the treatment of a para-anastomotic common iliac artery aneurysm and intermittent claudication, occurring after previous abdominal aortic thbe graft repair and femoro-femoral bypass graft. A case report. (20184072)
2009
21
Magic syndrome and true aortic aneurysm. (17657547)
2008
22
A novel COL3A1 gene mutation in patient with aortic dissected aneurysm and cervical artery dissections. (18389341)
2008
23
Extent of aortic coverage and incidence of spinal cord ischemia after thoracic endovascular aneurysm repair. (19021982)
2008
24
Matrix metalloproteinase 2 polymorphisms in a caucasian population with abdominal aortic aneurysm. (16458924)
2006
25
Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy. (16517327)
2006
26
Complex thoracic aortic aneurysm: a combined open and endovascular approach. (16184725)
2005
27
Surgical treatment of congenital right coronary artery aneurysm and fistula in a patient with previous aortic dissection repair. (15755715)
2005
28
Superior mesenteric artery syndrome: an uncommon complication of abdominal aortic aneurysm repair. (15253266)
2004
29
Is elective abdominal aortic aneurysm repair accompanied by high grade oxidative stress? (14582543)
2003
30
Aortic aneurysm and aortic regurgitation following aortic valve replacement due to Takayasu's arteritis. (11855100)
2002
31
Congenital abdominal aortic aneurysm causing renovascular hypertension, cardiomyopathy, and death in a 19-day-old neonate. (11528624)
2001
32
Endovascular stent graft repair of an infrarenal abdominal aortic aneurysm with a horseshoe kidney. (11319206)
2001
33
Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. (11342474)
2001
34
Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. (10825178)
2000
35
Growth curve of ruptured aortic aneurysm. (9537528)
1998
36
Chronic posttraumatic thoracic aortic aneurysm presenting with dysphagia. (7674415)
1995
37
Dissecting aortic aneurysm as a complication of generalized fibromuscular dysplasia. (1568754)
1992
38
Ascites after rupture of dissecting aortic aneurysm into the right atrium. (1985552)
1991
39
Ruptured abdominal aortic aneurysm. Analysis of 50 procedures. (1765714)
1991
40
Dissecting aortic aneurysm--failure of standard noninvasive and invasive diagnostic techniques. (1782649)
1991
41
Ruptured abdominal aortic aneurysm: the persistent challenge. (2913716)
1989
42
Unilateral absence of ventilation and perfusion due to thoracic aortic aneurysm. (3246118)
1988
43
Immobile right aortic leaflet in a case of the aortitis syndrome complicated by a left coronary sinus aneurysm. (3841908)
1985
44
Goretex graft replacement of left and right main stem coronary arteries in dissecting aortic aneurysm. (6204403)
1984
45
Ruptured abdominal aortic aneurysm causing obstructive jaundice. (6822186)
1983
46
Dissecting aortic aneurysm associated with congenital bicuspid aortic valve. (639201)
1978
47
Superior vena cava obstruction and dissecting aortic aneurysm. (1173444)
1975
48
Ruptured abdominal aortic aneurysm. (4830317)
1974
49
Ruptured aortic aneurysm in a 3 and one half-year-old child with coarctation of the aorta. (5763239)
1969
50
Dissecting aortic aneurysm. (13884634)
1962

Genetic Variations for Aortic Aneurysm

Expression for genes affiliated with Aortic Aneurysm

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for genes affiliated with Aortic Aneurysm

Sources:
52QIAGEN, 54Reactome, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 4Cell Signaling Technology, 60Tocris Bioscience
See all sources

Pathways related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4COL3A1, FBN1, MYLK, MYH11, MMP2, MMP8
2
Hide members
11.3COL3A1, FBN1, MYLK, MYH11, ACTA2, ELN
3
Hide members
11.2MMP2, MMP8, MMP12, MMP1, MMP9, ACTA2
4
Hide members
11.1COL3A1, FBN1, MMP2, MMP8, MMP12, MMP1
5
Cell adhesion ECM remodeling
Hide members
11.1ELN, COL3A1, MMP2, MMP8, MMP12, MMP1
611.1MMP2, MMP1, MMP9, SMAD3, TGFBR2, TGFBR1
7
Hide members
11.0TGFBR1, TGFBR2, ACTA2, MYH11, MYLK
8
Hide members
11.0TGFBR1, ACTA2, MMP9, MMP2, MYLK
9
Hide members
11.0MMP2, MMP8, MMP12, MMP1, MMP9
10
Hide members
10.9COL3A1, FBN1, ACTA2, TGFBR1
11
Transcription Androgen Receptor nuclear signaling
Hide members
10.9MMP2, SMAD3, TGFBR2, TGFBR1
1210.9MMP12, MMP1, TGFBR2, TGFBR1
13
Hide members
10.9COL3A1, MMP2, MMP8, MMP12
14
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.9MMP1, MMP9, ELANE, ELN
1510.8ACTA2, TGFBR2, TGFBR1
16
Hide members
10.8TGFBR1, TGFBR2, ELN
1710.8SMAD3, TGFBR2, TGFBR1
1810.8SMAD3, TGFBR2, TGFBR1
19
Hide members
10.8TGFBR1, TGFBR2, SMAD3
2010.8TGFBR1, TGFBR2, SMAD3
21
Hide members
10.8TGFBR1, TGFBR2, SMAD3
22
Development TGF-beta receptor signaling
Hide members
10.8TGFBR1, TGFBR2, SMAD3
2310.8TGFBR1, TGFBR2, SMAD3
24
Hide members
10.8SMAD3, TGFBR2, TGFBR1
2510.8TGFBR1, TGFBR2, SMAD3
26
Cytokine production by Th17 cells in CF (Mouse model)
10.8SMAD3, TGFBR2, TGFBR1
27
Hide members
10.8MYLK, MYH11, ACTA2
2810.8MMP2, MMP9, TGFBR1
2910.8MMP2, MMP1, MMP9
3010.8MMP2, MMP9, SMAD3
3110.8MMP2, MMP9, ELANE
32
Hide members
10.7TGFBR1, TGFBR2
33
Hide members
10.7TGFBR1, TGFBR2
3410.7TGFBR1, TGFBR2
35
Hide members
10.7TGFBR1, TGFBR2
36
Hide members
10.7TGFBR2, TGFBR1
37
Hide members
10.7TGFBR2, TGFBR1
38
Hide members
10.7ELN, ELANE
39
Hide members
10.7ELANE, MMP9
4010.6SMAD3

Compounds for genes affiliated with Aortic Aneurysm

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 11DrugBank
See all sources

Compounds related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1serine4511.9ELN, MMP9, TGFBR1, MMP1, MMP12, MMP2
2vegf4511.9ELN, MMP1, TGFBR2, TGFBR1, MMP12, MMP8
3retinoic acid45 2412.9TGFBR1, TGFBR2, ELANE, MMP9, MMP1, MMP8
4alanine4511.7TGFBR1, FBN1, ELN, TGFBR2, MYLK, SMAD3
5tgf beta14511.7MMP1, FBN1, TGFBR1, TGFBR2, ELN, MMP2
6cysteine4511.5ELANE, TGFBR2, ELN, MMP9, MMP1, MMP8
7genistein45 29 60 2 11 2416.5MMP12, TGFBR1, ELN, MMP9, MMP1, MMP8
8batimastat45 60 1113.5MMP8, MMP2, MMP12, MMP1, MMP9, ELANE
9progesterone45 60 29 11 2415.5TGFBR2, MMP1, MMP8, MYH11, FBN1, TGFBR1
10hyaluronic acid45 2412.5ELN, ELANE, MMP9, MMP1, MMP2, FBN1
11matrigel4511.4SMAD3, MMP9, MMP1, MMP12, MMP2, TGFBR1
12ribonucleic acid4511.4MMP2, MMP1, TGFBR2, TGFBR1, MMP9, COL3A1
13n acetylcysteine4511.4ELN, SMAD3, MMP12, MMP9, MMP2, MMP1
14uk 3833676011.4MMP8, MMP2, MMP9, MMP1, MMP12
15gm 60016011.4MMP1, MMP9, MMP12, MMP8, MMP2
16gi 254023x6011.4MMP12, MMP2, MMP9, MMP1, MMP8
17ly2940024511.4MMP2, MMP9, TGFBR2, TGFBR1, MYH11, SMAD3
18hydroxamate4511.4MMP9, MMP12, MMP8, MMP2, MMP1
19marimastat45 60 1113.4MMP12, MMP9, MMP2, MMP8, MMP1
20hydroxyproline45 11 2413.4ELN, MMP9, MMP1, MMP2, FBN1
21paraffin4511.4TGFBR1, ELN, MMP2, MMP1, MMP9, MYH11
22tetracycline45 1112.3MMP2, MMP8, MMP1, TGFBR2, MMP9
23cytochalasin d45 6012.3MMP1, MYLK, MMP2, MMP9, ACTA2
24ilomastat4511.3ELANE, MMP9, MMP1, MMP2
25cilomilast4511.3MMP9, MMP2, MMP1, ELANE
26lactate4511.3MMP8, MMP2, MMP1, MMP9, ELN, ELANE
27cyclosporin a45 29 6013.2COL3A1, MMP8, MMP1, ELANE, TGFBR2
28zinc45 2412.2MMP1, SMAD3, MMP9, MMP2, MMP8, MMP12
29doxycycline45 1112.2MMP8, MMP1, ELANE
30cgs-27023a4511.2MMP1, MMP2, MMP9
31vgvapg4511.2ELN, MMP1, MMP2
32nitric oxide45 11 2413.2MYLK, MMP12, SMAD3, TGFBR2, TGFBR1, MMP8
33desmosine4511.1FBN1, ELN, ELANE
34prinomastat4511.1MMP2, MMP1, MMP9
35(4-aminophenyl)mercuric acetate4511.1MMP8, ELANE
36vitamin a45 11 2413.1ELANE, MMP1, MMP9, MMP2
37gelfoam4511.1ELN, MMP2, MMP9
38latanoprost45 1112.1MMP9, MMP1, MMP2
39hematoxylin4511.0ELN, MMP1, MYH11
40bleomycin45 1112.0SMAD3, TGFBR2, ELN, MMP9
41estrogen4511.0ELN
42aprotinin45 1112.0MMP9, MMP1, MMP2, ELANE
43glutamate4510.9FBN1
44cycloheximide4510.9ELN
45cacl24510.9ELN, MMP8, FBN1
46pge24510.9MMP2, MMP9
47thermolysin4510.9ELN, ELANE
48glycosaminoglycan4510.8ELN, MMP9, MMP8, MMP1
49phxa 854510.7MMP1, MMP2
50sodium dodecylsulfate4510.5ELN, ELANE, FBN1

GO Terms for genes affiliated with Aortic Aneurysm

Sources:
16Gene Ontology
See all sources

Cellular components related to Aortic Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3COL3A1, FBN1, MMP2, MMP8, MMP12, MMP1
2proteinaceous extracellular matrixGO:00557811.2ELN, FBN1, MMP2, MMP8, MMP12, MMP1
3transforming growth factor beta receptor homodimeric complexGO:07002210.7TGFBR1, TGFBR2
4receptor complexGO:04323510.7SMAD3, TGFBR2, TGFBR1
5smooth muscle contractile fiberGO:03048510.4ACTA2, MYH11

Biological processes related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.6COL3A1, FBN1, MMP2, MMP8, MMP12, MMP1
2collagen catabolic processGO:03057411.4ELANE, COL3A1, MMP2, MMP8, MMP12, MMP1
3extracellular matrix disassemblyGO:02261711.4COL3A1, MMP2, MMP8, MMP12, MMP1, MMP9
4proteolysisGO:00650811.3MMP2, MMP8, MMP12, MMP1, MMP9, ELANE
5wound healingGO:04206011.1COL3A1, SMAD3, TGFBR2, TGFBR1
6transforming growth factor beta receptor signaling pathwayGO:00717911.0COL3A1, SMAD3, TGFBR2, TGFBR1
7skeletal system developmentGO:00150111.0TGFBR1, MMP9, FBN1, COL3A1
8embryonic cranial skeleton morphogenesisGO:04870111.0TGFBR1, TGFBR2, SMAD3
9heart developmentGO:00750710.9TGFBR1, TGFBR2, FBN1, COL3A1
10embryo implantationGO:00756610.9MMP2, MMP9, TGFBR2
11response to cholesterolGO:07072310.7TGFBR1, TGFBR2
12pathway-restricted SMAD protein phosphorylationGO:06038910.7TGFBR1, TGFBR2
13negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.7SMAD3, TGFBR2, TGFBR1
14muscle contractionGO:00693610.5ACTA2, MYH11, MYLK

Molecular functions related to Aortic Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422211.1MMP9, MMP1, MMP12, MMP8, MMP2
2SMAD bindingGO:04633210.8TGFBR1, TGFBR2, COL3A1
3extracellular matrix structural constituentGO:00520110.8COL3A1, FBN1, ELN
4transforming growth factor beta-activated receptor activityGO:00502410.7TGFBR1, TGFBR2
5transmembrane receptor protein serine/threonine kinase activityGO:00467510.6TGFBR1, TGFBR2
6transforming growth factor beta bindingGO:05043110.4TGFBR1, TGFBR2

Products for genes affiliated with Aortic Aneurysm

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aortic Aneurysm

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet