MCID: ART016
MIFTS: 70

Aortic Aneurysm malady

Cardiovascular diseases category

Summaries for Aortic Aneurysm

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35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 An aneurysm is a bulge or "ballooning" in the wall of an artery. arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. if an aneurysm grows large, it can burst and cause dangerous bleeding or even death. most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. there are two types of aortic aneurysm: thoracic aortic aneurysms - these occur in the part of the aorta running through the chest abdominal aortic aneurysms - these occur in the part of the aorta running through the abdomen most aneurysms are found during tests done for other reasons. some people are at high risk for aneurysms. it is important for them to get screening, because aneurysms can develop and become large before causing any symptoms screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. doctors use imaging tests to find aneurysms. medicines and surgery are the two main treatments. nih: national heart, lung, and blood institute

MalaCards: Aortic Aneurysm, also known as ruptured abdominal aortic aneurysm, is related to abdominal aortic aneurysm and aneurysm. An important gene associated with Aortic Aneurysm is ACTA2 (actin, alpha 2, smooth muscle, aorta), and among its related pathways are Striated Muscle Contraction and IL-2 Gene Expression in Activated and Quiescent T-Cells. The drug trimethaphan camsylate and the compounds vgvapg and cgs-27023a have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and heart, and related mouse phenotypes are craniofacial and integument.

Wikipedia:66 An aortic aneurysm is a general term for an enlargement (dilation) of the aorta to greater than 1.5... more...

Aliases & Classifications for Aortic Aneurysm

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9Disease Ontology, 11DISEASES, 35MedlinePlus, 63UMLS, 28ICD9CM, 41NCIt, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

aortic aneurysm 9 11 35 63
ruptured abdominal aortic aneurysm 9 11
aortic aneurysm of unspecified site, ruptured 9
thoracic aortic aneurysm which has ruptured 9
thoracoabdominal aortic aneurysm, ruptured 9
ruptured thoracoabdominal aortic aneurysm 9
abdominal aortic aneurysm, ruptured 9
thoracic aortic aneurysm, ruptured 9
ruptured thoracic aortic aneurysm 9
ruptured aortic aneurysm nos 9
ruptured thoracic aneurysm 9
ruptured aortic aneurysm 9


Related Diseases for Aortic Aneurysm

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18GeneCards, 19GeneDecks
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Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 314)
idRelated DiseaseScoreTop Affiliating Genes
1abdominal aortic aneurysm32.5MMP9
2aneurysm32.4ELN, COL3A1, MMP8, FBN1, TGFBR2, MMP9
3thoracic aortic aneurysm32.0ELN, FBN1, MYH11, MMP1, MMP2, TGFBR2
4marfan syndrome31.2ELN, TGFBR2, TGFBR1, FBN1, COL3A1
5thoracic aortic aneurysms and aortic dissections30.8TGFBR1, ACTA2, MYH11, TGFBR2
6loeys-dietz syndrome30.7TGFBR2, FBN1, TGFBR1, ACTA2, COL3A1
7ehlers-danlos syndrome30.7COL3A1, ELN, FBN1
8aortic disease30.6ELN, FBN1
9atherosclerosis30.5IL6, ELN, MMP8, MMP1, MMP2, MMP9
10coronary artery disease30.5IL6, MMP8, FBN1
11vascular disease30.5MMP9, TGFBR1, ELN
12ehlers-danlos syndrome type iv30.5ELN, COL3A1
13pneumonia30.4TGFB2, MMP8, IL6
14supravalvular aortic stenosis30.4FBN1, ELN
15lung cancer30.3TGFBR2, MMP1, MMP2, MMP9
16cutis laxa30.3FBN1, ELN
17intracranial aneurysm30.3COL3A1, ELN
18peritonitis30.3COL3A1, IL6, MMP8
19pseudoxanthoma elasticum30.1ELN, FBN1
20colorectal cancer30.1MMP2, MMP9, TGFB2, TGFBR2, MMP1
21colon cancer30.1MMP2, MMP9, TGFBR2, TGFBR1, SMAD3
22exfoliation syndrome30.1MMP1, FBN1, ELN
23transitional cell carcinoma30.1TGFBR2, MMP9, TGFBR1
24connective tissue disease30.1COL3A1, ELN, FBN1, TGFBR2
25osteoarthritis30.0MMP2, MMP1, IL6, MMP9, TGFB2, MMP8
26pulmonary emphysema30.0MMP8, MMP9, ELN, MMP1
27rheumatoid arthritis29.8IL6, MMP1, MMP8, MMP9, MMP2, TGFBR2
28arthritis29.8MMP2, FBN1, MMP1, MMP8, IL6, MMP9
29hepatocellular carcinoma29.7TGFB2, TGFBR2, TGFBR1, IL6, MMP2, FBN1
30dissecting aortic aneurysm11.1
31horseshoe kidney10.9
32ischemia10.8
33familial thoracic aortic aneurysm and dissection10.8
34duodenitis10.7
35aortitis10.7
36paraplegia10.7
37duodenal obstruction10.7
38hypertension10.6
39aortic coarctation10.5
40cerebritis10.5
41aortic aneurysm, familial thoracic 410.5
42endotheliitis10.5
43artery disease10.5
44disseminated intravascular coagulation10.5
45retroperitoneal fibrosis10.5
46dysphagia10.5
47takayasu's arteritis10.5
48superior mesenteric artery syndrome10.5
49pancreatitis10.5
50chylous ascites10.5

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to aortic aneurysm

Symptoms for Aortic Aneurysm

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Drugs & Therapeutics for Aortic Aneurysm

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Aortic Aneurysm

Drug clinical trials:

Search ClinicalTrials for Aortic Aneurysm

Search NIH Clinical Center for Aortic Aneurysm

Search CenterWatch for Aortic Aneurysm

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Aortic Aneurysm

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Anatomical Context for Aortic Aneurysm

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34MalaCards
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MalaCards organs/tissues related to Aortic Aneurysm:

34
Kidney, Lung, Heart, Spinal cord, Testes, Smooth muscle, Colon, Endothelial, Monocytes, T cells, Bone, Liver, Small intestine, Brain, Thyroid, Myeloid, Whole blood, Trachea

Animal Models for Aortic Aneurysm or affiliated genes

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38MGI
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Publications for Aortic Aneurysm

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53PubMed
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Articles related to Aortic Aneurysm:

(show top 50)    (show all 2620)
idTitleAuthorsYear
1
Preoperative cardiac evaluation by dipyridamole thallium-201 myocardial perfusion scan provides no benefit in patients with abdominal aortic aneurysm. (23995459)
2013
2
Embolization with Histoacryl Glue of an Anastomotic Pseudoaneurysm following Surgical Repair of Abdominal Aortic Aneurysm. (23476883)
2013
3
Listeriosis infection of an abdominal aortic aneurysm in a diabetic patient. (23599616)
2013
4
Endovascular repair with chimney technique of abdominal aortic aneurysm with hostile aortic neck. (23539067)
2013
5
Decreased tissue levels of cyclophilin A, a cyclosporine a target and phospho-ERK1/2 in simvastatin patients with abdominal aortic aneurysm. (23558220)
2013
6
Treatment of abdominal aortic aneurysm with a new type of polymer-filled low profile device. (24380546)
2013
7
Ruptured common femoral artery aneurysm or abdominal aortic aneurysm? (24386587)
2013
8
Successful use of talc sclerodesis to control a persistent high-output groin seroma following endovascular abdominal aortic aneurysm repair. (23711974)
2013
9
A case of severe aortic valve regurgitation caused by an ascending aortic aneurysm in a young patient with autosomal dominant polycystic kidney disease and normal renal function. (22396705)
2012
10
Inflammaging and Proteases in Abdominal Aortic Aneurysm. (22724479)
2012
11
Inverse production of IL-6 and IL-10 by abdominal aortic aneurysm explant tissues in culture. (22445549)
2012
12
Arteriosclerotic abdominal aortic aneurysm rupture into the vena cava. (23304039)
2012
13
Repair of thoracic aortic aneurysm due to noninfectious aortitis. (22309320)
2012
14
To use or not to use heparin during abdominal aortic aneurysm repair? (22841359)
2012
15
Management of a parturient with a thoracic aortic aneurysm. (21441805)
2011
16
Endovascular aneurysm repair reverses the increased titer and the inflammatory activity of interleukin-1I+ in the serum of patients with abdominal aortic aneurysm. (21620624)
2011
17
Superior nationwide outcomes of endovascular versus open repair for isolated descending thoracic aortic aneurysm in 11,669 patients. (20951252)
2010
18
Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome. (20189193)
2010
19
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. (19720934)
2009
20
Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm. (19690470)
2009
21
Can surgeons assess CT suitability for endovascular repair (EVAR) in ruptured abdominal aortic aneurysm? Implications for a ruptured EVAR trial. (18401641)
2008
22
Aortic aneurysm in Takayasu's arteritis. (17985414)
2007
23
Hypotensive hemostatis (permissive hypotension) for ruptured abdominal aortic aneurysm: are we really in control? (17714634)
2007
24
The soluble forms of CD28, CD86 and CTLA-4 constitute possible immunological markers in patients with abdominal aortic aneurysm. (17391115)
2007
25
Compound heterozygous mutations in fibulin-4 causing neonatal lethal pulmonary artery occlusion, aortic aneurysm, arachnodactyly, and mild cutis laxa. (17937443)
2007
26
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)
2006
27
Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. (17182923)
2006
28
Takayasu's arteritis with aortic aneurysm associated with Sweet's syndrome in childhood. (15608327)
2005
29
Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy. (16103255)
2005
30
F-18 FDG PET imaging features of a perigraft leak and thrombus in a patient with dissecting descending thoracic aortic aneurysm. (15483501)
2004
31
Emergent surgery for 3 aged patients who refused elective operation for thoracic aortic aneurysm. (14529161)
2003
32
Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm. (14681642)
2003
33
Is elective abdominal aortic aneurysm repair accompanied by high grade oxidative stress? (14582543)
2003
34
Ruptured abdominal aortic aneurysm presenting as groin pain. (11942452)
2002
35
Salvage of an acutely ruptured thoracic aortic aneurysm during CPR. (12166844)
2002
36
Human abdominal aortic aneurysm is characterized by decreased versican concentration and specific downregulation of versican isoform V(0). (11166769)
2001
37
Primary autologous superficial femoral vein reconstruction of an emergency, infected, ruptured aortic aneurysm. (11735207)
2001
38
High prevalence of mild hyperhomocysteinemia in patients with abdominal aortic aneurysm. (10957660)
2000
39
Special cerebral perfusion in surgery for the ruptured thoracic aortic aneurysm. (10522790)
1999
40
Mixed agonistic-antagonistic cytokine response in whole blood from patients undergoing abdominal aortic aneurysm repair. (10229162)
1999
41
Angiogenesis is associated with mononuclear inflammatory cells in abdominal aortic aneurysms. (9598229)
1998
42
Endotoxin related early neutrophil activation is associated with outcome after thoracoabdominal aortic aneurysm repair. (9052426)
1997
43
An unusual presentation of a ruptured abdominal aortic aneurysm. (8581256)
1995
44
Outcome in patients who require renal support after surgery for ruptured abdominal aortic aneurysm. (8044595)
1994
45
Thoracic aortic aneurysm and rupture in giant cell arteritis. A descriptive study of 41 cases. (7864947)
1994
46
Seasonal variation in the incidence of ruptured abdominal aortic aneurysm. (1298219)
1992
47
Ruptured abdominal aortic aneurysm with horseshoe kidney. (6502842)
1984
48
Disseminated intravascular coagulation in dissecting aortic aneurysm. A case report. (7290724)
1981
49
Early diagnosis of tuberculous thoracic aortic aneurysm by computerized axial tomography. (699543)
1978
50
Prolonged shock in dissecting aortic aneurysm. (13338901)
1956

Variations for Aortic Aneurysm

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Expression for genes affiliated with Aortic Aneurysm

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for genes affiliated with Aortic Aneurysm

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 55R&D Systems, 61Thomson Reuters, 31KEGG, 58SinoBiological, 5Cell Signaling Technology, 13EMD Millipore
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Pathways related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MYLK, MYH11, ACTA2
2
Show member pathways
9.6TGFBR2, TGFBR1, TGFB2
39.6TGFB2, TGFBR1, TGFBR2
49.6TGFBR2, TGFBR1, TGFB2
5
Show member pathways
9.6TGFB2, ELN, FBN1
6
Show member pathways
9.6SMAD3, TGFBR1, TGFBR2
79.6TGFBR1, SMAD3, TGFBR2
89.6TGFBR1, TGFBR2, SMAD3
99.6TGFBR1, SMAD3, TGFBR2
109.6SMAD3, TGFBR2, TGFBR1
11
Show member pathways
9.6SMAD3, TGFBR2, TGFBR1
129.5MMP9, ELN, MMP1
139.4TGFBR2, TGFB2, ACTA2, TGFBR1
149.3SMAD3, MMP2, MMP9
159.3IL6, MMP2, MMP9
169.3MMP2, MMP9, IL6
179.3TGFBR1, IL6, SMAD3
189.2IL6, TGFB2, MMP2
19
Show member pathways
9.2TGFB2, MYH11, TGFBR1, TGFBR2, ACTA2
209.2SMAD3, TGFBR1, TGFB2, TGFBR2
219.2TGFB2, SMAD3, TGFBR1, TGFBR2
229.2TGFBR2, TGFB2, TGFBR1, SMAD3
239.2SMAD3, TGFBR2, TGFBR1, TGFB2
24
Show member pathways
Signal transduction PTEN pathway61
9.2TGFB2, TGFBR2, SMAD3, TGFBR1
25
Show member pathways
9.2SMAD3, TGFB2, TGFBR2, TGFBR1
269.2TGFB2, SMAD3, TGFBR2, TGFBR1
27
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.2SMAD3, TGFB2, TGFBR2, TGFBR1
28
Show member pathways
9.2TGFB2, TGFBR1, TGFBR2, SMAD3
299.2TGFB2, TGFBR2, TGFBR1, SMAD3
309.2MMP2, MMP9, TGFBR1, TGFB2
31
Show member pathways
9.1MMP9, MMP2, MMP8, MMP1
32
Show member pathways
9.1TGFBR2, TGFBR1, SMAD3, IL6
339.0IL6, MMP1, MMP2, MMP9
34
Show member pathways
8.8TGFB2, TGFBR1, MYLK, IL6, TGFBR2
35
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
8.8IL6, MMP2, TGFBR1, SMAD3, TGFBR2
36
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
8.7IL6, TGFB2, TGFBR2, TGFBR1, SMAD3
378.7TGFBR2, TGFBR1, SMAD3, TGFB2, IL6
38
Show member pathways
8.7TGFBR1, TGFBR2, SMAD3, TGFB2, IL6
39
Show member pathways
8.6TGFBR1, TGFB2, MYLK, IL6, ACTA2, TGFBR2
40
Show member pathways
8.6MMP8, MMP1, ELN, COL3A1, MMP9, MMP2
41
Show member pathways
8.4TGFBR1, TGFB2, MYLK, MYH11, ACTA2, IL6
42
Show member pathways
8.4TGFBR1, TGFB2, ELN, COL3A1, IL6, ACTA2
43
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.3TGFB2, SMAD3, TGFBR1, TGFBR2, MMP9, IL6
44
Show member pathways
8.2MMP2, MMP9, ACTA2, TGFBR1, TGFB2, MYLK
458.1IL6, TGFBR1, TGFBR2, TGFB2, MMP9, MMP1
46
Show member pathways
8.0MMP1, ELN, FBN1, TGFB2, MMP9, MMP2
477.7IL6, MMP1, MMP2, SMAD3, MMP9, TGFBR1
48
Show member pathways
7.6MYLK, MYH11, ELN, ACTA2, IL6, COL3A1
49
Show member pathways
7.6TGFBR1, TGFBR2, IL6, ACTA2, MMP1, MMP8
50
Show member pathways
6.8MMP8, FBN1, TGFBR1, TGFBR2, TGFB2, MYLK

Compounds for genes affiliated with Aortic Aneurysm

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB, 30IUPHAR, 52PharmGKB
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Compounds related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1vgvapg4610.0ELN, MMP1, MMP2
2cgs-27023a469.9MMP2, MMP1, MMP9
3prinomastat469.8MMP2, MMP1, MMP9
4gelfoam469.7MMP2, MMP9, ELN
5ilomastat469.7MMP1, MMP2, MMP9
6latanoprost46 1210.5MMP1, MMP9, MMP2
7gm 6001629.5MMP1, MMP8, MMP2, MMP9
8gi 254023x629.5MMP1, MMP2, MMP8, MMP9
9uk 383367629.5MMP9, MMP2, MMP1, MMP8
10hydroxamate469.5MMP2, MMP8, MMP1, MMP9
11cilomilast469.5MMP2, MMP1, MMP9
12marimastat46 62 1211.5MMP1, MMP8, MMP2, MMP9
13hydroxyproline46 25 1211.4MMP9, MMP1, MMP2, FBN1, ELN
14batimastat46 62 1211.4MMP8, MMP2, MMP9, MMP1
15(4-aminophenyl)mercuric acetate469.3MMP2, MMP1, MMP9, MMP8, ELN
16doxycycline46 1210.3MMP1, MMP8, MMP2, MMP9, ELN
17tetracycline46 1210.3MMP2, MMP1, MMP8, MMP9, TGFBR2
18cytochalasin d46 6210.3MMP1, MYLK, MMP9, MMP2, ACTA2
19hematoxylin469.3MYH11, MMP1, ELN, MMP9
20zoledronic acid469.3IL6, MMP9, MMP1, MMP2
21ivig469.2IL6, ELN, MMP2, MMP9
22glycosaminoglycan469.1ELN, MMP1, TGFB2, MMP9, MMP8
23hydrocortisone46 3 62 1212.0ELN, TGFB2, MMP2, MMP1, IL6
24procollagen468.9COL3A1, MMP9, SMAD3, ELN, MMP1, MMP2
25ribonucleic acid468.8TGFB2, COL3A1, MMP1, MMP2, TGFBR2, TGFBR1
26paraffin468.8MYH11, TGFB2, ELN, MMP1, MMP2, MMP9
27matrigel468.8TGFBR1, MMP2, MMP9, SMAD3, MMP1, TGFB2
28vitamin d468.7SMAD3, FBN1, TGFBR2, TGFB2, ELN, IL6
29progesterone46 30 62 25 1212.6MMP8, MMP1, MMP2, TGFBR1, MYH11, TGFB2
30ly294002468.6TGFBR1, IL6, MYH11, MMP9, MMP2, SMAD3
31vitamin a46 25 1210.5MMP1, MMP2, MMP9, TGFB2, ELN
32hyaluronic acid46 259.5IL6, ELN, MMP1, MMP2, MMP9, FBN1
33glutamate468.5MYLK, COL3A1, ELN, TGFB2, TGFBR2, MMP2
34cyclosporin a46 30 6210.4MMP8, IL6, TGFB2, TGFBR2, COL3A1, MMP9
35pge2468.4MMP8, TGFBR2, TGFB2, MMP9, MMP2, MMP1
36dexamethasone46 52 30 1211.4TGFBR1, TGFBR2, TGFB2, MMP9, MMP1, ELN
37cysteine468.3MMP2, MMP9, ELN, MMP1, MMP8, TGFB2
38lactate468.3ELN, MMP9, MMP2, MMP8, MMP1, IL6
39n acetylcysteine468.3SMAD3, IL6, ELN, MMP9, TGFB2, MMP2
40genistein46 30 62 3 25 1213.2TGFBR1, TGFB2, MMP9, MMP2, MMP8, ELN
41nitric oxide46 25 1210.2IL6, SMAD3, TGFBR2, TGFB2, MYLK, MMP8
42testosterone46 62 25 1211.1MMP9, MMP2, MMP1, ELN, TGFB2, IL6
43cycloheximide467.9MMP1, IL6, TGFBR2, TGFB2, TGFBR1, SMAD3
44alanine467.7MYLK, ELN, MMP9, MMP2, MMP8, SMAD3
45tgf beta1467.6FBN1, TGFBR2, TGFBR1, SMAD3, MMP9, MMP2
46tyrosine467.6MYLK, TGFB2, TGFBR2, FBN1, SMAD3, MMP9
47retinoic acid46 258.5MMP9, MMP8, TGFBR1, MMP2, TGFBR2, TGFB2
48serine467.3ELN, MMP1, SMAD3, MMP2, MMP9, MYH11
49vegf467.3IL6, MMP1, ELN, MMP8, MMP2, MMP9
50estrogen467.1MMP1, ELN, IL6, MMP2, MYH11, MYLK

GO Terms for genes affiliated with Aortic Aneurysm

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17Gene Ontology
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Cellular components related to Aortic Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor homodimeric complexGO:07002210.0TGFBR2, TGFBR1
2smooth muscle contractile fiberGO:0304859.9MYH11, ACTA2
3extracellular matrixGO:0310129.6COL3A1, FBN1, TGFB2
4receptor complexGO:0432359.3TGFBR2, TGFBR1, SMAD3
5proteinaceous extracellular matrixGO:0055788.8ELN, FBN1, MMP9, MMP2, MMP8, MMP1
6extracellular spaceGO:0056157.9FBN1, TGFB2, MMP9, MMP2, MMP8, ACTA2
7extracellular regionGO:0055767.6COL3A1, FBN1, TGFB2, IL6, ELN, MMP1

Biological processes related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:07072310.3TGFBR2, TGFBR1
2smooth muscle contractionGO:00693910.2MYH11, MYLK
3negative regulation of immune responseGO:05077710.0COL3A1, TGFB2
4muscle contractionGO:00693610.0ACTA2, MYH11, MYLK
5pathway-restricted SMAD protein phosphorylationGO:06038910.0TGFBR1, TGFBR2, TGFB2
6neuron fate commitmentGO:04866310.0TGFB2, TGFBR1
7digestive tract developmentGO:04856510.0TGFBR2, COL3A1
8positive regulation of epithelial cell migrationGO:01063410.0TGFBR2, TGFB2
9embryonic cranial skeleton morphogenesisGO:0487019.9TGFBR2, TGFBR1, SMAD3
10embryo implantationGO:0075669.9MMP2, MMP9, TGFBR2
11regulation of transforming growth factor beta2 productionGO:0329099.9SMAD3, TGFB2
12collagen fibril organizationGO:0301999.9TGFBR1, TGFB2, COL3A1
13negative regulation of transforming growth factor beta receptor signaling pathwayGO:0305129.9SMAD3, TGFBR1, TGFBR2
14response to mechanical stimulusGO:0096129.8COL3A1, IL6, TGFBR2
15activation of protein kinase activityGO:0321479.8TGFBR2, TGFB2
16lens development in camera-type eyeGO:0020889.7TGFBR1, TGFBR2
17skeletal system developmentGO:0015019.7FBN1, TGFBR1, MMP9, COL3A1
18agingGO:0075689.7TGFBR2, IL6, COL3A1
19protein phosphorylationGO:0064689.6TGFBR1, TGFBR2, TGFB2, MYLK
20cell cycle arrestGO:0070509.6TGFB2, TGFBR1, SMAD3
21positive regulation of epithelial to mesenchymal transitionGO:0107189.6TGFB2, SMAD3
22heart developmentGO:0075079.5COL3A1, TGFB2, TGFBR2, TGFBR1, FBN1
23proteolysisGO:0065089.5MMP1, MMP8, MMP2, MMP9
24response to hypoxiaGO:0016669.4SMAD3, TGFB2, MMP2
25positive regulation of cell proliferationGO:0082849.3TGFBR1, TGFBR2, TGFB2, IL6
26wound healingGO:0420609.3SMAD3, TGFBR1, TGFBR2, TGFB2, COL3A1
27transforming growth factor beta receptor signaling pathwayGO:0071799.3SMAD3, TGFBR1, TGFBR2, TGFB2, COL3A1
28collagen catabolic processGO:0305749.2MMP9, MMP2, MMP8, MMP1, COL3A1
29extracellular matrix disassemblyGO:0226178.8COL3A1, FBN1, MMP9, MMP2, MMP8, MMP1
30extracellular matrix organizationGO:0301988.4FBN1, TGFB2, MMP9, MMP2, MMP8, MMP1

Molecular functions related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:05043110.0TGFBR2, TGFBR1
2SMAD bindingGO:0463329.9COL3A1, TGFBR2, TGFBR1
3type II transforming growth factor beta receptor bindingGO:0051149.8TGFB2, TGFBR1
4extracellular matrix structural constituentGO:0052019.8FBN1, ELN, COL3A1
5transforming growth factor beta-activated receptor activityGO:0050249.7TGFBR2, TGFBR1
6transforming growth factor beta receptor bindingGO:0051609.5TGFB2, SMAD3
7metalloendopeptidase activityGO:0042229.3MMP1, MMP8, MMP2, MMP9
8protein bindingGO:0055156.9TGFB2, TGFBR2, TGFBR1, FBN1, SMAD3, MYLK

Products for genes affiliated with Aortic Aneurysm

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aortic Aneurysm

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet