Aliases & Classifications for Aortic Aneurysm

MalaCards integrated aliases for Aortic Aneurysm:

Name: Aortic Aneurysm 12 72 28 40 3 41 14 69
Thoracoabdominal Aortic Aneurysm, Ruptured 12 69
Ruptured Abdominal Aortic Aneurysm 12 69
Ruptured Thoracic Aortic Aneurysm 12 69
Aortic Rupture 41 69
Aortic Aneurysm Without Mention of Rupture Nos 69
Aortic Aneurysm of Unspecified Site, Ruptured 12
Thoracic Aortic Aneurysm Which Has Ruptured 12
Ruptured Thoracoabdominal Aortic Aneurysm 12
Abdominal Aortic Aneurysm, Ruptured 12
Thoracic Aortic Aneurysm, Ruptured 12
Ruptured Aortic Aneurysm Nos 12
Ruptured Thoracic Aneurysm 12
Aortic Aneurysm, Ruptured 69
Ruptured Aortic Aneurysm 12

Classifications:



Summaries for Aortic Aneurysm

MedlinePlus : 40 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. There are two types of aortic aneurysm: Thoracic aortic aneurysms (TAA) - these occur in the part of the aorta running through the chest Abdominal aortic aneurysms (AAA) - these occur in the part of the aorta running through the abdomen Most aneurysms are found during tests done for other reasons. Some people are at high risk for aneurysms. It is important for them to get screening, because aneurysms can develop and become large before causing any symptoms. Screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. Doctors use imaging tests to find aneurysms. Medicines and surgery are the two main treatments. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Aortic Aneurysm, also known as thoracoabdominal aortic aneurysm, ruptured, is related to aortic aneurysm, familial thoracic 4 and familial thoracic aortic aneurysm and dissection, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Aortic Aneurysm is ACTA2 (Actin, Alpha 2, Smooth Muscle, Aorta), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Valsartan and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and testes, and related phenotypes are cardiovascular system and cellular

Disease Ontology : 12 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC : 3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia : 72 An aortic aneurysm is an enlargement (dilation) of the aorta to greater than 1.5 times normal size. They... more...

Related Diseases for Aortic Aneurysm

Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 344)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial thoracic 4 34.3 FBN1 MYH11
2 familial thoracic aortic aneurysm and dissection 34.1 FBN1 SMAD3 TGFBR1 TGFBR2
3 familial abdominal aortic aneurysm 34.0 ELN FBN1
4 aortic aneurysm, familial abdominal, 1 33.5 AAAS ELN FBN1 MMP13 MMP9
5 loeys-dietz syndrome 32.9 ACTA2 FBN1 SMAD3 TGFB2 TGFBR1 TGFBR2
6 cutis laxa, autosomal dominant 1 32.3 ELN FBLN5
7 aortic aneurysm, familial thoracic 1 31.9 AAT1 ACTA2 EFEMP2 ELN FBN1 MFAP5
8 marfan syndrome 30.7 ACTA2 ELN FBN1 TGFBR1 TGFBR2
9 arterial tortuosity syndrome 30.2 EFEMP2 ELN TGFBR1
10 inguinal hernia 29.9 ELN FBN1 MMP13 MMP9
11 cutis laxa 29.8 EFEMP2 ELN FBLN5
12 exfoliation syndrome 29.8 ELN FBN1 LOX
13 supravalvular aortic stenosis 29.6 ELN FBLN5 FBN1 MMP9
14 connective tissue disease 29.4 ACTA2 ELN FBLN5 FBN1
15 pneumothorax 29.4 ELN FBLN5 FBN1 MMP9
16 mitral valve disease 29.3 FBN1 MMP13 TGFB2
17 aneurysm 29.2 AAT1 ACTA2 EFEMP2 ELN FOXE3 LOX
18 aortic disease 28.5 AAAS ACTA2 ELN FBN1 MMP9 PRKG1
19 aortic aneurysm, familial thoracic 6 12.4
20 aortic aneurysm, familial thoracic 7 12.4
21 aortic aneurysm, familial thoracic 10 12.4
22 aortic aneurysm, familial thoracic 9 12.4
23 aortic aneurysm, familial thoracic 11 12.4
24 aortic aneurysm, familial thoracic 8 12.3
25 aortic aneurysm, familial abdominal, 2 12.1
26 aortic aneurysm, familial thoracic 2 12.1
27 aortic aneurysm, familial abdominal, 4 12.1
28 loeys-dietz syndrome 1 12.1
29 aortic aneurysm, familial abdominal, 3 12.1
30 loeys-dietz syndrome 2 11.8
31 temporal arteritis 11.3
32 loeys-dietz syndrome 3 11.3
33 multisystemic smooth muscle dysfunction syndrome 11.3
34 meester-loeys syndrome 11.2
35 phace association 11.0
36 cutis laxa, autosomal dominant 2 11.0
37 cutis laxa, autosomal recessive, type ib 11.0
38 loeys-dietz syndrome 4 11.0
39 loeys-dietz syndrome 5 11.0
40 cutis laxa, autosomal dominant 3 11.0
41 cystic medial necrosis of aorta 11.0
42 horseshoe kidney 10.5
43 transient hypogammaglobulinemia of infancy 10.4 TGFBR1 TGFBR2
44 acquired cutis laxa 10.4 ELN FBLN5
45 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.4 ELN FBN1
46 ischemia 10.4
47 late-onset focal dermal elastosis 10.4 ELN FBN1
48 transient hypogammaglobulinemia 10.4 TGFBR1 TGFBR2
49 cutis laxa, autosomal recessive type 1 10.4 EFEMP2 FBLN5
50 cutis laxa, autosomal recessive, type ia 10.3 EFEMP2 FBLN5

Comorbidity relations with Aortic Aneurysm via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Acute Vascular Insufficiency of Intestine Aortic Valve Disease 1
Cardiac Arrest Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Paralytic Ileus Peripheral Vascular Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to Aortic Aneurysm

Symptoms & Phenotypes for Aortic Aneurysm

UMLS symptoms related to Aortic Aneurysm:


edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Aortic Aneurysm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.38 FBN1 KLF15 ACTA2 LOX EFEMP2 MFAP5
2 cellular MP:0005384 10.23 MMP9 FBN1 AAAS EFEMP2 MMP13 FBLN5
3 homeostasis/metabolism MP:0005376 10.21 MMP9 FBN1 AAAS KLF15 LOX MMP13
4 growth/size/body region MP:0005378 10.18 FBLN5 MMP9 FBN1 AAAS KLF15 MMP13
5 digestive/alimentary MP:0005381 10.09 MMP9 AAAS TGFBR1 PRKG1 TGFBR2 SMAD3
6 muscle MP:0005369 10.07 MMP9 FBN1 KLF15 ACTA2 LOX EFEMP2
7 integument MP:0010771 9.97 MMP9 FBN1 LOX EFEMP2 MMP13 FBLN5
8 renal/urinary system MP:0005367 9.76 MMP9 FBN1 KLF15 MYLK PRKG1 SMAD3
9 respiratory system MP:0005388 9.61 MMP9 FBN1 LOX EFEMP2 FBLN5 TGFBR2
10 skeleton MP:0005390 9.32 MMP9 FBN1 EFEMP2 MFAP5 MMP13 MYLK

Drugs & Therapeutics for Aortic Aneurysm

Drugs for Aortic Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 230)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
2
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
3
Atenolol Approved Phase 4 29122-68-7 2249
4
Angiotensin II Approved, Investigational Phase 4,Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
5
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
6
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
7
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
8
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
9
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
10
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
11
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
12
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
13
Iodine Approved, Investigational Phase 4 7553-56-2 807
14
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
15
Remifentanil Approved Phase 4 132875-61-7 60815
16
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
17
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
18
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
19
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
20
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
21
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
22
Eplerenone Approved Phase 4 107724-20-9 443872 150310
23
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
24
Clevidipine Approved, Investigational Phase 4 167221-71-8
25 Atorvastatin Calcium Phase 4,Phase 3,Phase 2 134523-03-8
26 diuretics Phase 4
27 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
28 Adrenergic Agents Phase 4,Early Phase 1
29 Adrenergic Antagonists Phase 4,Early Phase 1
30 Adrenergic beta-1 Receptor Antagonists Phase 4,Early Phase 1
31 Adrenergic beta-Antagonists Phase 4,Early Phase 1
32 Sympatholytics Phase 4,Early Phase 1
33 Natriuretic Agents Phase 4,Phase 3
34 Coagulants Phase 4,Phase 3
35 Neurotransmitter Agents Phase 4,Phase 2,Early Phase 1
36 Hemostatics Phase 4,Phase 3
37 Anesthetics Phase 4,Phase 3,Phase 1
38 Hormone Antagonists Phase 4
39 Hormones Phase 4
40 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3
41 Angiotensin Receptor Antagonists Phase 4,Phase 3
42 Angiotensinogen Phase 4,Phase 3
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
44 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Early Phase 1
45 Anti-Arrhythmia Agents Phase 4,Phase 3
46 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2
47 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
48 Anticonvulsants Phase 4
49 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
50 Hypolipidemic Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 509)

# Name Status NCT ID Phase Drugs
1 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
2 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Unknown status NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
3 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
4 Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery Unknown status NCT01889498 Phase 4 Acetazolamide
5 Tranexamic Acid in Major Vascular Surgery Unknown status NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
6 Endovascular Repair of Descending Thoracic Aortic Aneurysms Completed NCT00802984 Phase 4
7 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
8 Endovascular Repair of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
9 Standard Open Surgery Versus Endovascular Repair of Abdominal Aortic Aneurysm (AAA) Completed NCT00094575 Phase 4
10 GORE EXCLUDER® Endoprosthesis - Low Permeability in Treatment of Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
11 Statin Use in Abdominal Aortic Aneurysm Repair Completed NCT01062802 Phase 4 Atorvastatin
12 Opioid-potentiated Volative Anaesthetic Vs. Remifentanil And Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
13 CUstodiol Versus RInger: whaT Is the Best Agent? Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
14 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
15 Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair Completed NCT02677532 Phase 4 Paracetamol;Levobupivacaine wound infiltration;Levobupivacaine epidural bolus;Sufentanil epidural bolus;Morphine;Levobupivacaine plus sufentanil epidural infusion;Levobupivacaine wound infusion
16 Thoracoabdominal Arortic CTA Study Completed NCT02291718 Phase 4 Isovue
17 The Pharmacokinetics of Opioids and Sedative/Hypnotics During Selective Cerebral Perfusion Completed NCT00494598 Phase 4 Sufentanil
18 Fibrinogen as an Alternative to FFP in Aortic Surgery. Completed NCT00994045 Phase 4
19 Vasculopathic Injury and Plasma as Endothelial Rescue - OCTAplas Trial (EudraCT no. 2014-000452-28) Completed NCT02253082 Phase 4 OctaplasLG®
20 Atorvastatin in Perioperative Vascular Surgery - Pilot Study Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
21 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From Abdominal Aorta Surgery Completed NCT00819936 Phase 4
22 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
23 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
24 Eplerenone in the Management of Abdominal Aortic Aneurysms Recruiting NCT02345590 Phase 4 Eplerenone
25 Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Recruiting NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
26 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
27 AAA Registry: Clinical Outcomes of Highly Angulated anatomY Treated With the Aorfix™ Stent Graft Recruiting NCT02480595 Phase 4
28 Bloodtranfusions After Aortic Surgery Recruiting NCT02299947 Phase 4 Haemocomplettan P;Placebo
29 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Recruiting NCT02678728 Phase 4 Dexmedetomidine;normal saline
30 Pilot Study of of Renal Arterial Sympathetic Denervation by Cryotherapy Active, not recruiting NCT02345603 Phase 4
31 Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR Devices Enrolling by invitation NCT02407457 Phase 4
32 Comparison of Surveillance Versus Aortic Endografting for Small Aneurysm Repair Terminated NCT00118573 Phase 4
33 Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms Terminated NCT00409344 Phase 4 Dexmedetomidine
34 The (PIVOTAL) Study Terminated NCT00444821 Phase 4
35 Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection Terminated NCT01354119 Phase 4
36 A Safety and Efficacy Study of Blood Pressure Control in Acute Aortic Emergencies - A Pilot Study (PROMPT) Terminated NCT01033370 Phase 4 clevidipine.
37 ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique Withdrawn NCT01107366 Phase 4
38 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
39 34mm Cuff Study for Endovascular Repair of Abdominal Aortic Aneurysms Unknown status NCT00706394 Phase 2, Phase 3
40 Magnetic Resonance Imaging of Aortic Aneurysm Instability Unknown status NCT00794092 Phase 2, Phase 3 Sinerem administration
41 Study of Aortic Root Reimplantation Procedure Unknown status NCT01787604 Phase 3
42 The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure Unknown status NCT00110201 Phase 3 Nesiritide
43 Clinical Evaluation of a Modular Extracorporeal Circulation Circuit Unknown status NCT02000544 Phase 3
44 Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients Unknown status NCT00125463 Phase 3 Candesartan cilexetil
45 Study of the Endovascular QUANTUM LP™ Stent Graft System in Abdominal Aortic Aneurysms (AAA) Completed NCT00233688 Phase 3
46 Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair Completed NCT01225094 Phase 2, Phase 3 curcumin
47 Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair Completed NCT00671203 Phase 3
48 ARBITER-II: Aorfix™ Bifurcated Safety and Performance Trial: Phase II, Angulated Vessels Completed NCT00442065 Phase 2, Phase 3
49 Melatonin and Cardiac Outcome After Major Surgery Completed NCT00315926 Phase 2, Phase 3 Melatonin;Placebo
50 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: aortic aneurysm

Genetic Tests for Aortic Aneurysm

Genetic tests related to Aortic Aneurysm:

# Genetic test Affiliating Genes
1 Aortic Aneurysm 28

Anatomical Context for Aortic Aneurysm

MalaCards organs/tissues related to Aortic Aneurysm:

38
Kidney, Heart, Testes, Lung, Spinal Cord, Endothelial, Smooth Muscle

Publications for Aortic Aneurysm

Articles related to Aortic Aneurysm:

(show top 50) (show all 3166)
# Title Authors Year
1
A custom-made TreovanceAr abdominal aortic aneurysm endograft to correct late failure of trombone technique with a tube endograft. ( 29421425 )
2018
2
Renal Fenestration Closure Technique in fenestrated endovascular repair for para-renal aortic aneurysm. ( 29421424 )
2018
3
Rupture of an Abdominal Aortic Aneurysm in a Young Man with Marfan Syndrome. ( 29421423 )
2018
4
Clinical outcomes of total endovascular aneurysm repair for aortic aneurysms involving the proximal anastomotic aneurysm following initial open repair for infrarenal abdominal aortic aneurysm. ( 29421415 )
2018
5
Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation. ( 29408196 )
2018
6
Ten-year experience of the thoraco-abdominal aortic aneurysm treatment using a hybrid thoracic endovascular aortic repair. ( 29415193 )
2018
7
Increased risk of malignancy in patients with an aortic aneurysm: a nationwide population-based retrospective study. ( 29416815 )
2018
8
Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm. ( 29432192 )
2018
9
A case of a rectal stricture related to ischemic proctitis following rupture of an aortic aneurysm. ( 29399616 )
2018
10
Spinal cord injury in endovascular thoracoabdominal aortic aneurysm repair: prevalence, risk factors and preventive strategies. ( 29424186 )
2018
11
Snorkel Technique for Inferior Mesenteric Artery During Endovascular Repair of Abdominal Aortic Aneurysm. ( 29433410 )
2018
12
Impact of Medical Therapy on Late Morbidity and Mortality After Aortic Aneurysm Repair for Aortitis. ( 29408240 )
2018
13
Increased Risk of Peripheral Arterial Disease in Patients With Abdominal Aortic Aneurysm: A Retrospective Cohort Study (Version 5). ( 29444589 )
2018
14
The Effect of a Non-peptide Angiotensin II type 2 receptor Agonist, Compound 21, on Aortic Aneurysm Growth in a Mouse Model of Marfan Syndrome. ( 29300219 )
2018
15
Association of carotid atherosclerosis and stiffness with abdominal aortic aneurysm: The atherosclerosis risk in communities (ARIC) study. ( 29407878 )
2018
16
Abdominal aortic aneurysm calcification: trying to identify a reliable semiquantitative method. ( 29430885 )
2018
17
Thiol/disulphide homeostasis in thoracic aortic aneurysm and acute aortic syndrome. ( 29436236 )
2018
18
Postoperative Chylothorax after Thoracoabdominal Aortic Aneurysm Repair. ( 29428620 )
2018
19
Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset. ( 29439675 )
2018
20
Impact of abdominal aortic aneurysm screening on quality ofA life. ( 29405273 )
2018
21
Nationwide analysis of risk factors for in-hospital mortality in patients undergoing abdominal aortic aneurysm repair. ( 29417985 )
2018
22
Screening for Abdominal Aortic Aneurysm During Transthoracic Echocardiography: A Systematic Review and Meta-analysis. ( 29433798 )
2018
23
Adventitial adipogenic degeneration is an unidentified contributor to aortic wall weakening in the abdominal aortic aneurysm. ( 28912007 )
2017
24
Early reintervention after open and endovascular abdominal aortic aneurysm repair is associated with high mortality. ( 28943011 )
2017
25
Atherosclerotic vascular diseases have really the same risk factors? Comparison between large abdominal aortic aneurysm and obstructive non-coronary arterial disease. ( 28509621 )
2017
26
Pseudoachalasia Secondary to Thoracic Aortic Aneurysm. ( 28528055 )
2017
27
Use of V-POSSUM and E-PASS Scores to Predict Acute Kidney Injury after Elective Open Abdominal Aortic Aneurysm Surgery. ( 28887266 )
2017
28
Non-visualized aorta in abdominal aortic aneurysm screening: Screening outcomes and the influence of subject and programme characteristics. ( 28077001 )
2017
29
Lifestyle and Risk of Screening-Detected Abdominal Aortic Aneurysm in Men. ( 28490522 )
2017
30
The effects of preoperative cardiology consultation prior to elective abdominal aortic aneurysm repair on patient morbidity. ( 28059000 )
2017
31
Reoperation rates after open and endovascular abdominal aortic aneurysm repairs. ( 28073669 )
2017
32
Reporting individual surgeon outcomes does not lead to risk aversion in abdominal aortic aneurysm surgery. ( 28071950 )
2017
33
Decreased Serum Levels of High Mobility Group Box 1 (HMGB-1) after Graft Replacement or Stenting of Abdominal Aortic Aneurysm. ( 27908811 )
2017
34
Using multiple classifiers for predicting the risk of endovascular aortic aneurysm repair re-intervention through hybrid feature selection. ( 28925817 )
2017
35
Thoracoabdominal aortic aneurysm repair in Marfan syndrome: how we do it. ( 29270385 )
2017
36
A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms. ( 27887857 )
2017
37
Bile-ated Cell Death Decreases Aortic Aneurysm Formation. ( 28089083 )
2017
38
Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study. ( 28915698 )
2017
39
The Incidence of Ischemic Colitis after Repair of Ruptured Abdominal Aortic Aneurysms is Decreasing in the Endovascular Era. ( 28919522 )
2017
40
Simple Identification of the Adamkiewicz Artery in Extended Thoracoabdominal Aortic Aneurysm Repair. ( 28528073 )
2017
41
Prominent Tendon Xanthomas and Abdominal Aortic Aneurysm Associated with Cerebrotendinous Xanthomatosis Identified Using Whole Exome Sequencing. ( 29269672 )
2017
42
On the influence of wall calcification and intraluminal thrombus on prediction of abdominal aortic aneurysm rupture. ( 28899569 )
2017
43
A Simple Blood Test, Such as Complete Blood Count, Can Predict Calcification Grade of Abdominal Aortic Aneurysm. ( 28948050 )
2017
44
Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies. ( 28339009 )
2017
45
Permanent Decline of Renal Function After Infrarenal Abdominal Aortic Aneurysm Repair - Frequency and Risk Factors. ( 28943483 )
2017
46
Update on Screening for Abdominal Aortic Aneurysm. ( 28526395 )
2017
47
Correlation of Intraluminal Thrombus Deposition, Biomechanics, and Hemodynamics with Surface Growth and Rupture in Abdominal Aortic Aneurysm-Application in a Clinical Paradigm. ( 28887252 )
2017
48
Experiences of the screening process and the diagnosis abdominal aortic aneurysm among 65-year-old men from invitation to a 1-year surveillance. ( 28527730 )
2017
49
Angiotensin II infusion into ApoE-/- mice: a model for aortic dissection rather than abdominal aortic aneurysm? ( 28898997 )
2017
50
Infrarenal Infected Aortic Aneurysm Caused by Streptococcus pyogenes. ( 28503338 )
2017

Variations for Aortic Aneurysm

ClinVar genetic disease variations for Aortic Aneurysm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FBN1 NM_000138.4(FBN1): c.7754T> C (p.Ile2585Thr) single nucleotide variant Pathogenic/Likely pathogenic rs727503054 GRCh37 Chromosome 15, 48712949: 48712949

Expression for Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for Aortic Aneurysm

Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 ACTA2 EFEMP2 ELN FBN1 MYH11 MYLK
2
Show member pathways
13.28 ACTA2 MYH11 MYLK SMAD3 TGFB2 TGFBR1
3
Show member pathways
13.05 ACTA2 EFEMP2 ELN FBN1 TGFB2 TGFBR1
4
Show member pathways
12.99 ACTA2 EFEMP2 ELN FBN1 MMP13 MMP9
5
Show member pathways
12.9 ACTA2 MYH11 PRKG1 TGFB2 TGFBR1 TGFBR2
6 12.81 MMP9 SMAD3 TGFB2 TGFBR1 TGFBR2
7
Show member pathways
12.48 ACTA2 MMP13 MMP9 SMAD3 TGFBR1 TGFBR2
8
Show member pathways
12.44 SMAD3 TGFB2 TGFBR1 TGFBR2
9 12.39 SMAD3 TGFB2 TGFBR1 TGFBR2
10
Show member pathways
12.26 EFEMP2 ELN FBLN5 FBN1 LOX MFAP5
11
Show member pathways
12.2 SMAD3 TGFB2 TGFBR1 TGFBR2
12 12.15 SMAD3 TGFB2 TGFBR1 TGFBR2
13 12.12 SMAD3 TGFB2 TGFBR1 TGFBR2
14
Show member pathways
12.11 SMAD3 TGFB2 TGFBR1 TGFBR2
15 12.07 MMP9 SMAD3 TGFB2 TGFBR1 TGFBR2
16
Show member pathways
12.05 SMAD3 TGFB2 TGFBR1 TGFBR2
17 12.04 ACTA2 MYLK SMAD3 TGFBR1
18 11.98 ACTA2 SMAD3 TGFB2 TGFBR1 TGFBR2
19
Show member pathways
11.96 ACTA2 EFEMP2 ELN FBN1 MMP13 MMP9
20 11.88 SMAD3 TGFB2 TGFBR1 TGFBR2
21 11.86 SMAD3 TGFB2 TGFBR1 TGFBR2
22
Show member pathways
11.83 SMAD3 TGFBR1 TGFBR2
23
Show member pathways
11.83 SMAD3 TGFB2 TGFBR1 TGFBR2
24 11.8 MMP13 MMP9 TGFB2 TGFBR1
25 11.76 SMAD3 TGFB2 TGFBR1 TGFBR2
26 11.71 SMAD3 TGFBR1 TGFBR2
27 11.71 SMAD3 TGFBR1 TGFBR2
28
Show member pathways
11.71 LOX SMAD3 TGFBR1 TGFBR2
29
Show member pathways
11.69 SMAD3 TGFBR1 TGFBR2
30 11.66 MMP13 MMP9 SMAD3
31 11.65 MMP13 MMP9 TGFB2
32 11.59 SMAD3 TGFBR1 TGFBR2
33 11.53 SMAD3 TGFBR1 TGFBR2
34
Show member pathways
11.49 MMP9 SMAD3 TGFB2 TGFBR1 TGFBR2
35 11.42 MMP13 TGFB2 TGFBR1 TGFBR2
36 11.41 MMP13 SMAD3 TGFBR1
37 11.37 ACTA2 MYLK TGFB2 TGFBR1 TGFBR2
38 11.33 ACTA2 MYH11 MYLK
39 11.15 SMAD3 TGFB2 TGFBR1 TGFBR2
40 11.05 SMAD3 TGFBR1 TGFBR2
41
Show member pathways
11.03 EFEMP2 ELN FBLN5 FBN1 LOX MFAP5
42 11.02 FBN1 SMAD3 TGFBR1 TGFBR2
43 10.99 EFEMP2 ELN FBN1 MYLK TGFB2
44 10.92 TGFB2 TGFBR1 TGFBR2

GO Terms for Aortic Aneurysm

Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 ACTA2 EFEMP2 FBLN5 FBN1 LOX MFAP5
2 extracellular matrix GO:0031012 9.5 ELN FBLN5 FBN1 MFAP5 MMP13 MMP9
3 microfibril GO:0001527 9.37 FBN1 MFAP5
4 elastic fiber GO:0071953 9.32 ELN FBLN5
5 transforming growth factor beta receptor complex GO:0070022 9.26 TGFBR1 TGFBR2
6 proteinaceous extracellular matrix GO:0005578 9.17 ELN FBLN5 FBN1 LOX MFAP5 MMP13
7 extracellular region GO:0005576 10.06 EFEMP2 ELN FBLN5 FBN1 LOX MFAP5

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.88 MMP9 MYLK SMAD3 TGFBR1
2 heart development GO:0007507 9.85 FBN1 LOX TGFB2 TGFBR1 TGFBR2
3 muscle contraction GO:0006936 9.82 ACTA2 MYH11 MYLK
4 kidney development GO:0001822 9.82 FBN1 TGFB2 TGFBR1
5 palate development GO:0060021 9.79 TGFB2 TGFBR1 TGFBR2
6 transforming growth factor beta receptor signaling pathway GO:0007179 9.78 SMAD3 TGFB2 TGFBR1 TGFBR2
7 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.77 SMAD3 TGFBR1 TGFBR2
8 skeletal system development GO:0001501 9.77 FBN1 MMP9 SMAD3 TGFB2 TGFBR1
9 cellular response to transforming growth factor beta stimulus GO:0071560 9.75 FBN1 SMAD3 TGFBR1
10 collagen fibril organization GO:0030199 9.73 LOX TGFB2 TGFBR1
11 extracellular matrix disassembly GO:0022617 9.73 ELN FBN1 MMP13 MMP9
12 extracellular matrix organization GO:0030198 9.73 ELN FBLN5 FBN1 LOX MFAP5 MMP9
13 lens development in camera-type eye GO:0002088 9.71 FOXE3 TGFBR1 TGFBR2
14 embryonic cranial skeleton morphogenesis GO:0048701 9.7 SMAD3 TGFBR1 TGFBR2
15 ventricular septum morphogenesis GO:0060412 9.67 TGFB2 TGFBR1 TGFBR2
16 activin receptor signaling pathway GO:0032924 9.64 SMAD3 TGFBR1
17 ventricular trabecula myocardium morphogenesis GO:0003222 9.63 TGFB2 TGFBR1
18 positive regulation of SMAD protein import into nucleus GO:0060391 9.63 SMAD3 TGFBR1
19 cardiac epithelial to mesenchymal transition GO:0060317 9.62 TGFB2 TGFBR1
20 positive regulation of epithelial to mesenchymal transition GO:0010718 9.62 SMAD3 TGFB2 TGFBR1 TGFBR2
21 atrioventricular valve morphogenesis GO:0003181 9.61 TGFB2 TGFBR2
22 response to cholesterol GO:0070723 9.61 TGFBR1 TGFBR2
23 membranous septum morphogenesis GO:0003149 9.6 TGFB2 TGFBR2
24 pathway-restricted SMAD protein phosphorylation GO:0060389 9.58 TGFB2 TGFBR1 TGFBR2
25 growth plate cartilage development GO:0003417 9.57 MMP13 TGFBR2
26 regulation of transforming growth factor beta2 production GO:0032909 9.55 SMAD3 TGFB2
27 wound healing GO:0042060 9.55 LOX SMAD3 TGFB2 TGFBR1 TGFBR2
28 endocardial cushion fusion GO:0003274 9.51 TGFB2 TGFBR2
29 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.13 TGFB2 TGFBR1 TGFBR2
30 elastic fiber assembly GO:0048251 8.92 EFEMP2 FBLN5 LOX MYH11

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen binding GO:0005518 9.5 MMP13 MMP9 SMAD3
2 signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.4 TGFBR1 TGFBR2
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.37 TGFBR1 TGFBR2
4 type II transforming growth factor beta receptor binding GO:0005114 9.26 TGFB2 TGFBR1
5 transforming growth factor beta-activated receptor activity GO:0005024 9.16 TGFBR1 TGFBR2
6 SMAD binding GO:0046332 9.13 SMAD3 TGFBR1 TGFBR2
7 extracellular matrix structural constituent GO:0005201 8.92 EFEMP2 ELN FBN1 MFAP5

Sources for Aortic Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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