MCID: ART016
MIFTS: 62

Aortic Aneurysm malady

Cardiovascular diseases category

Summaries for Aortic Aneurysm

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MedlinePlus:32 An aneurysm is a bulge or "ballooning" in the wall of an artery. arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. if an aneurysm grows large, it can burst and cause dangerous bleeding or even death. most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. there are two types of aortic aneurysm: thoracic aortic aneurysms - these occur in the part of the aorta running through the chest abdominal aortic aneurysms - these occur in the part of the aorta running through the abdomen most aneurysms are found during tests done for other reasons. some people are at high risk for aneurysms. it is important for them to get screening, because aneurysms can develop and become large before causing any symptoms screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. doctors use imaging tests to find aneurysms. medicines and surgery are the two main treatments. nih: national heart, lung, and blood institute

MalaCards based summary: Aortic Aneurysm, also known as ruptured abdominal aortic aneurysm, is related to abdominal aortic aneurysm and aneurysm. An important gene associated with Aortic Aneurysm is ACTA2 (actin, alpha 2, smooth muscle, aorta), and among its related pathways are Striated Muscle Contraction and IL-2 Gene Expression in Activated and Quiescent T-Cells. The drug trimethaphan camsylate and the compounds vgvapg and cgs-27023a have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and lung, and related mouse phenotypes are craniofacial and integument.

Disease Ontology:9 An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size.

CDC:3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia:63 An aortic aneurysm is enlargement (dilation) of the aorta to greater than 1.5 times normal size. They... more...

Aliases & Classifications for Aortic Aneurysm

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Aortic Aneurysm, Aliases & Descriptions:

Name: Aortic Aneurysm 9 11 32 3 60
Ruptured Abdominal Aortic Aneurysm 9 11 60
Thoracoabdominal Aortic Aneurysm, Ruptured 9 60
Ruptured Thoracic Aortic Aneurysm 9 60
Aortic Aneurysm Without Mention of Rupture Nos 60
Aortic Aneurysm of Unspecified Site, Ruptured 9
Thoracic Aortic Aneurysm Which Has Ruptured 9
 
Ruptured Thoracoabdominal Aortic Aneurysm 9
Abdominal Aortic Aneurysm, Ruptured 9
Thoracic Aortic Aneurysm, Ruptured 9
Ruptured Aortic Aneurysm Nos 9
Ruptured Thoracic Aneurysm 9
Aortic Aneurysm, Ruptured 60
Ruptured Aortic Aneurysm 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Related Diseases for Aortic Aneurysm

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Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 317)
idRelated DiseaseScoreTop Affiliating Genes
1abdominal aortic aneurysm33.1MMP9
2aneurysm32.0COL3A1, ELN, MMP8, MMP2, MMP9, FBN1
3thoracic aortic aneurysm31.9FBN1, ELN, MMP1, MMP2, MYH11, TGFBR2
4marfan syndrome31.4FBN1, TGFBR1, TGFBR2, ELN, COL3A1
5thoracic aortic aneurysms and aortic dissections31.2ACTA2, MYH11, TGFBR2, TGFBR1
6aortic disease31.1FBN1, ELN
7ehlers-danlos syndrome31.0COL3A1, ELN, FBN1
8ehlers-danlos syndrome, type iv31.0ELN, COL3A1
9loeys-dietz syndrome30.9COL3A1, ACTA2, TGFBR2, TGFBR1, FBN1
10cutis laxa30.8FBN1, ELN
11intracranial aneurysm30.7ELN, COL3A1
12coronary artery disease30.7IL6, MMP8, FBN1
13vascular disease30.6ELN, MMP9, TGFBR1
14pseudoxanthoma elasticum30.6ELN, FBN1
15exfoliation syndrome30.4FBN1, MMP1, ELN
16peritonitis30.4COL3A1, IL6, MMP8
17lung cancer30.3MMP1, MMP2, MMP9, TGFBR2
18transitional cell carcinoma30.3TGFBR1, TGFBR2, MMP9
19connective tissue disease30.3COL3A1, ELN, TGFBR2, FBN1
20pneumonia30.2TGFB2, MMP8, IL6
21fibrosarcoma30.0MMP9, MMP2, MMP1
22pulmonary emphysema29.9ELN, MMP1, MMP8, MMP9
23colorectal cancer29.8SMAD3, TGFBR1, TGFBR2, MMP9, MMP2
24atherosclerosis29.8FBN1, MYH11, MMP9, MMP2, MMP8, MMP1
25rheumatoid arthritis29.4TGFBR2, MMP9, MMP2, MMP8, MMP1, IL6
26arthritis29.4FBN1, MMP9, MMP2, MMP8, MMP1, IL6
27osteoarthritis29.4TGFB2, MMP9, MMP2, MMP8, MMP1, IL6
28hepatocellular carcinoma28.7SMAD3, FBN1, TGFBR1, TGFBR2, TGFB2, MMP9
29dissecting aortic aneurysm11.1
30horseshoe kidney10.9
31ischemia10.8
32familial thoracic aortic aneurysm and dissection10.8
33duodenitis10.7
34aortitis10.7
35duodenal obstruction10.7
36paraplegia10.7
37artery disease10.6
38aortic coarctation10.6
39geleophysic dysplasia 210.5FBN1
40acromicric dysplasia10.5FBN1
41disseminated intravascular coagulation10.5
42hereditary hemorrhagic telangiectasia10.5TGFBR1
43aortic aneurysm, familial thoracic 110.5
44aortic aneurysm, familial thoracic 410.5
45cerebritis10.5
46retroperitoneal fibrosis10.5
47dysphagia10.5
48endotheliitis10.5
49homocysteinemia10.5ELN
50takayasu's arteritis10.5

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to aortic aneurysm

Symptoms for Aortic Aneurysm

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Drugs & Therapeutics for Aortic Aneurysm

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Drug clinical trials:

Search ClinicalTrials for Aortic Aneurysm

Search NIH Clinical Center for Aortic Aneurysm

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Aortic Aneurysm

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Anatomical Context for Aortic Aneurysm

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MalaCards organs/tissues related to Aortic Aneurysm:

31
Kidney, Heart, Lung, Spinal cord, Testes, Smooth muscle, Colon, Neutrophil, Endothelial, Monocytes, T cells, Bone, Brain, Small intestine, Liver, Whole blood, Thyroid, Myeloid, Trachea

Animal Models for Aortic Aneurysm or affiliated genes

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Publications for Aortic Aneurysm

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Articles related to Aortic Aneurysm:

(show top 50)    (show all 2737)
idTitleAuthorsYear
1
Concept of the aortic aneurysm repair-related surgical stress: a review of the literature. (25356092)
2014
2
Is intervention better than surveillance in patients with type 2 endoleak post-endovascular abdominal aortic aneurysm repair? (25301297)
2014
3
Preoperative cardiac evaluation by dipyridamole thallium-201 myocardial perfusion scan provides no benefit in patients with abdominal aortic aneurysm. (23995459)
2013
4
Embolization with Histoacryl Glue of an Anastomotic Pseudoaneurysm following Surgical Repair of Abdominal Aortic Aneurysm. (23476883)
2013
5
Listeriosis infection of an abdominal aortic aneurysm in a diabetic patient. (23599616)
2013
6
Endovascular repair with chimney technique of abdominal aortic aneurysm with hostile aortic neck. (23539067)
2013
7
Decreased tissue levels of cyclophilin A, a cyclosporine a target and phospho-ERK1/2 in simvastatin patients with abdominal aortic aneurysm. (23558220)
2013
8
Treatment of abdominal aortic aneurysm with a new type of polymer-filled low profile device. (24380546)
2013
9
Ruptured common femoral artery aneurysm or abdominal aortic aneurysm? (24386587)
2013
10
A case of severe aortic valve regurgitation caused by an ascending aortic aneurysm in a young patient with autosomal dominant polycystic kidney disease and normal renal function. (22396705)
2012
11
Inflammaging and Proteases in Abdominal Aortic Aneurysm. (22724479)
2012
12
Inverse production of IL-6 and IL-10 by abdominal aortic aneurysm explant tissues in culture. (22445549)
2012
13
Arteriosclerotic abdominal aortic aneurysm rupture into the vena cava. (23304039)
2012
14
To use or not to use heparin during abdominal aortic aneurysm repair? (22841359)
2012
15
Management of a parturient with a thoracic aortic aneurysm. (21441805)
2011
16
Endovascular aneurysm repair reverses the increased titer and the inflammatory activity of interleukin-1I+ in the serum of patients with abdominal aortic aneurysm. (21620624)
2011
17
Superior nationwide outcomes of endovascular versus open repair for isolated descending thoracic aortic aneurysm in 11,669 patients. (20951252)
2010
18
Effectiveness of combination of losartan potassium and doxycycline versus single-drug treatments in the secondary prevention of thoracic aortic aneurysm in Marfan syndrome. (20189193)
2010
19
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. (19720934)
2009
20
Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm. (19690470)
2009
21
Can surgeons assess CT suitability for endovascular repair (EVAR) in ruptured abdominal aortic aneurysm? Implications for a ruptured EVAR trial. (18401641)
2008
22
Aortic aneurysm in Takayasu's arteritis. (17985414)
2007
23
Hypotensive hemostatis (permissive hypotension) for ruptured abdominal aortic aneurysm: are we really in control? (17714634)
2007
24
The soluble forms of CD28, CD86 and CTLA-4 constitute possible immunological markers in patients with abdominal aortic aneurysm. (17391115)
2007
25
Compound heterozygous mutations in fibulin-4 causing neonatal lethal pulmonary artery occlusion, aortic aneurysm, arachnodactyly, and mild cutis laxa. (17937443)
2007
26
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. (16444274)
2006
27
Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. (17182923)
2006
28
Takayasu's arteritis with aortic aneurysm associated with Sweet's syndrome in childhood. (15608327)
2005
29
Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy. (16103255)
2005
30
F-18 FDG PET imaging features of a perigraft leak and thrombus in a patient with dissecting descending thoracic aortic aneurysm. (15483501)
2004
31
Emergent surgery for 3 aged patients who refused elective operation for thoracic aortic aneurysm. (14529161)
2003
32
Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm. (14681642)
2003
33
Is elective abdominal aortic aneurysm repair accompanied by high grade oxidative stress? (14582543)
2003
34
Ruptured abdominal aortic aneurysm presenting as groin pain. (11942452)
2002
35
Salvage of an acutely ruptured thoracic aortic aneurysm during CPR. (12166844)
2002
36
Human abdominal aortic aneurysm is characterized by decreased versican concentration and specific downregulation of versican isoform V(0). (11166769)
2001
37
Primary autologous superficial femoral vein reconstruction of an emergency, infected, ruptured aortic aneurysm. (11735207)
2001
38
High prevalence of mild hyperhomocysteinemia in patients with abdominal aortic aneurysm. (10957660)
2000
39
Special cerebral perfusion in surgery for the ruptured thoracic aortic aneurysm. (10522790)
1999
40
Mixed agonistic-antagonistic cytokine response in whole blood from patients undergoing abdominal aortic aneurysm repair. (10229162)
1999
41
Angiogenesis is associated with mononuclear inflammatory cells in abdominal aortic aneurysms. (9598229)
1998
42
Endotoxin related early neutrophil activation is associated with outcome after thoracoabdominal aortic aneurysm repair. (9052426)
1997
43
An unusual presentation of a ruptured abdominal aortic aneurysm. (8581256)
1995
44
Outcome in patients who require renal support after surgery for ruptured abdominal aortic aneurysm. (8044595)
1994
45
Thoracic aortic aneurysm and rupture in giant cell arteritis. A descriptive study of 41 cases. (7864947)
1994
46
Seasonal variation in the incidence of ruptured abdominal aortic aneurysm. (1298219)
1992
47
Ruptured abdominal aortic aneurysm with horseshoe kidney. (6502842)
1984
48
Disseminated intravascular coagulation in dissecting aortic aneurysm. A case report. (7290724)
1981
49
Early diagnosis of tuberculous thoracic aortic aneurysm by computerized axial tomography. (699543)
1978
50
Prolonged shock in dissecting aortic aneurysm. (13338901)
1956

Variations for Aortic Aneurysm

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Expression for genes affiliated with Aortic Aneurysm

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Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for genes affiliated with Aortic Aneurysm

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Pathways related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show top 50)    (show all 68)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MYLK, MYH11, ACTA2
2
Show member pathways
9.6TGFB2, TGFBR2, TGFBR1
39.6TGFB2, TGFBR2, TGFBR1
49.6TGFBR1, TGFBR2, TGFB2
5
Show member pathways
9.6FBN1, TGFB2, ELN
69.6SMAD3, TGFBR1, TGFBR2
7
Show member pathways
9.6SMAD3, TGFBR1, TGFBR2
8
Show member pathways
9.6TGFBR2, TGFBR1, SMAD3
99.6TGFBR2, TGFBR1, SMAD3
109.6TGFBR2, TGFBR1, SMAD3
119.6TGFBR2, TGFBR1, SMAD3
129.5ELN, MMP1, MMP9
139.4TGFBR1, TGFBR2, TGFB2, ACTA2
149.3SMAD3, MMP9, MMP2
159.3IL6, MMP2, MMP9
169.3IL6, MMP2, MMP9
179.3SMAD3, TGFBR1, IL6
189.2TGFB2, MMP2, IL6
19
Show member pathways
9.2TGFBR1, TGFBR2, TGFB2, MYH11, ACTA2
20
Show member pathways
9.2SMAD3, TGFBR1, TGFBR2, TGFB2
21
Show member pathways
9.2SMAD3, TGFBR1, TGFBR2, TGFB2
229.2SMAD3, TGFBR1, TGFBR2, TGFB2
239.2SMAD3, TGFBR1, TGFBR2, TGFB2
249.2SMAD3, TGFBR1, TGFBR2, TGFB2
25
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.2SMAD3, TGFBR1, TGFBR2, TGFB2
26
Show member pathways
Signal transduction PTEN pathway58
9.2TGFB2, TGFBR2, TGFBR1, SMAD3
279.2TGFB2, TGFBR2, TGFBR1, SMAD3
289.2TGFB2, TGFBR2, TGFBR1, SMAD3
299.2TGFB2, TGFBR2, TGFBR1, SMAD3
309.2TGFBR1, TGFB2, MMP9, MMP2
31
Show member pathways
9.1MMP9, MMP2, MMP8, MMP1
32
Show member pathways
9.1SMAD3, TGFBR1, TGFBR2, IL6
339.0MMP9, MMP2, MMP1, IL6
34
Show member pathways
8.8TGFBR1, TGFBR2, TGFB2, MYLK, IL6
35
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
8.8SMAD3, TGFBR1, TGFBR2, MMP2, IL6
368.7SMAD3, TGFBR1, TGFBR2, TGFB2, IL6
37
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
8.7SMAD3, TGFBR1, TGFBR2, TGFB2, IL6
38
Show member pathways
8.7SMAD3, TGFBR1, TGFBR2, TGFB2, IL6
39
Show member pathways
8.6TGFBR1, TGFBR2, TGFB2, MYLK, ACTA2, IL6
40
Show member pathways
Metalloproteases in connective tissue degradation
8.6MMP9, MMP2, MMP8, MMP1, ELN, COL3A1
41
Show member pathways
8.4TGFBR1, TGFBR2, TGFB2, MYLK, MYH11, ACTA2
42
Show member pathways
8.4FBN1, TGFBR1, TGFB2, ELN, ACTA2, IL6
43
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.3SMAD3, TGFBR1, TGFBR2, TGFB2, MMP9, IL6
44
Show member pathways
8.2TGFBR1, TGFB2, MYLK, MMP9, MMP2, ACTA2
458.1TGFBR1, TGFBR2, TGFB2, MMP9, MMP2, MMP1
46
Show member pathways
8.0FBN1, TGFB2, MMP9, MMP2, MMP8, MMP1
477.7SMAD3, TGFBR1, TGFBR2, TGFB2, MMP9, MMP2
48
Show member pathways
7.6FBN1, TGFBR1, TGFBR2, TGFB2, MYLK, MYH11
49
Show member pathways
7.6TGFBR1, TGFBR2, TGFB2, MMP9, MMP2, MMP8
50
Show member pathways
6.8COL3A1, FBN1, TGFBR1, TGFBR2, TGFB2, MYLK

Compounds for genes affiliated with Aortic Aneurysm

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Compounds related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1vgvapg4310.0ELN, MMP1, MMP2
2cgs-27023a439.9MMP2, MMP1, MMP9
3prinomastat439.8MMP2, MMP1, MMP9
4gelfoam439.7MMP2, MMP9, ELN
5ilomastat439.7MMP1, MMP2, MMP9
6latanoprost43 1210.5MMP1, MMP9, MMP2
7gm 6001599.5MMP1, MMP8, MMP2, MMP9
8gi 254023x599.5MMP1, MMP2, MMP8, MMP9
9uk 383367599.5MMP9, MMP2, MMP1, MMP8
10hydroxamate439.5MMP2, MMP8, MMP1, MMP9
11cilomilast439.5MMP2, MMP1, MMP9
12marimastat43 59 1211.5MMP1, MMP8, MMP2, MMP9
13hydroxyproline43 24 1211.4MMP9, MMP1, MMP2, FBN1, ELN
14batimastat43 59 1211.4MMP8, MMP2, MMP9, MMP1
15(4-aminophenyl)mercuric acetate439.3MMP2, MMP1, MMP9, MMP8, ELN
16doxycycline43 1210.3MMP1, MMP8, MMP2, MMP9, ELN
17tetracycline43 1210.3MMP2, MMP1, MMP8, MMP9, TGFBR2
18cytochalasin d43 5910.3MMP1, MYLK, MMP9, MMP2, ACTA2
19hematoxylin439.3MYH11, MMP1, ELN, MMP9
20zoledronic acid439.3IL6, MMP9, MMP1, MMP2
21ivig439.2IL6, ELN, MMP2, MMP9
22glycosaminoglycan439.1ELN, MMP1, TGFB2, MMP9, MMP8
23hydrocortisone43 2 59 1212.0ELN, TGFB2, MMP2, MMP1, IL6
24procollagen438.9COL3A1, MMP9, SMAD3, ELN, MMP1, MMP2
25ribonucleic acid438.8TGFB2, COL3A1, MMP1, MMP2, TGFBR2, TGFBR1
26paraffin438.8MYH11, TGFB2, ELN, MMP1, MMP2, MMP9
27matrigel438.8TGFBR1, MMP2, MMP9, SMAD3, MMP1, TGFB2
28vitamin d438.7SMAD3, FBN1, TGFBR2, TGFB2, ELN, IL6
29progesterone43 28 59 24 1212.6MMP8, MMP1, MMP2, TGFBR1, MYH11, TGFB2
30ly294002438.6TGFBR1, IL6, MYH11, MMP9, MMP2, SMAD3
31vitamin a43 24 1210.5MMP1, MMP2, MMP9, TGFB2, ELN
32hyaluronic acid43 249.5IL6, ELN, MMP1, MMP2, MMP9, FBN1
33glutamate438.5MYLK, COL3A1, ELN, TGFB2, TGFBR2, MMP2
34cyclosporin a43 28 5910.4MMP8, IL6, TGFB2, TGFBR2, COL3A1, MMP9
35pge2438.4MMP8, TGFBR2, TGFB2, MMP9, MMP2, MMP1
36dexamethasone43 49 28 1211.4TGFBR1, TGFBR2, TGFB2, MMP9, MMP1, ELN
37cysteine438.3MMP2, MMP9, ELN, MMP1, MMP8, TGFB2
38lactate438.3ELN, MMP9, MMP2, MMP8, MMP1, IL6
39n acetylcysteine438.3SMAD3, IL6, ELN, MMP9, TGFB2, MMP2
40genistein43 28 59 2 24 1213.2TGFBR1, TGFB2, MMP9, MMP2, MMP8, ELN
41nitric oxide43 24 1210.2IL6, SMAD3, TGFBR2, TGFB2, MYLK, MMP8
42testosterone43 59 24 1211.1MMP9, MMP2, MMP1, ELN, TGFB2, IL6
43cycloheximide437.9MMP1, IL6, TGFBR2, TGFB2, TGFBR1, SMAD3
44alanine437.7MYLK, ELN, MMP9, MMP2, MMP8, SMAD3
45tgf beta1437.6FBN1, TGFBR2, TGFBR1, SMAD3, MMP9, MMP2
46tyrosine437.6MYLK, TGFB2, TGFBR2, FBN1, SMAD3, MMP9
47retinoic acid43 248.5MMP9, MMP8, TGFBR1, MMP2, TGFBR2, TGFB2
48serine437.3ELN, MMP1, SMAD3, MMP2, MMP9, MYH11
49vegf437.3IL6, MMP1, ELN, MMP8, MMP2, MMP9
50estrogen437.1MMP1, ELN, IL6, MMP2, MYH11, MYLK

GO Terms for genes affiliated with Aortic Aneurysm

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Cellular components related to Aortic Aneurysm according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor homodimeric complexGO:007002210.0TGFBR1, TGFBR2
2smooth muscle contractile fiberGO:00304859.9MYH11, ACTA2
3extracellular matrixGO:00310129.6COL3A1, TGFB2, FBN1
4receptor complexGO:00432359.3TGFBR2, TGFBR1, SMAD3
5proteinaceous extracellular matrixGO:00055788.8ELN, FBN1, MMP9, MMP2, MMP8, MMP1
6extracellular spaceGO:00056157.9FBN1, TGFB2, MMP9, MMP2, MMP8, ACTA2
7extracellular regionGO:00055767.6FBN1, TGFB2, MMP9, MMP2, MMP8, MMP1

Biological processes related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:007072310.3TGFBR2, TGFBR1
2smooth muscle contractionGO:000693910.2MYH11, MYLK
3negative regulation of immune responseGO:005077710.0COL3A1, TGFB2
4muscle contractionGO:000693610.0ACTA2, MYH11, MYLK
5pathway-restricted SMAD protein phosphorylationGO:006038910.0TGFBR1, TGFBR2, TGFB2
6neuron fate commitmentGO:004866310.0TGFB2, TGFBR1
7digestive tract developmentGO:004856510.0TGFBR2, COL3A1
8positive regulation of epithelial cell migrationGO:001063410.0TGFBR2, TGFB2
9embryonic cranial skeleton morphogenesisGO:00487019.9TGFBR2, TGFBR1, SMAD3
10embryo implantationGO:00075669.9MMP2, MMP9, TGFBR2
11regulation of transforming growth factor beta2 productionGO:00329099.9SMAD3, TGFB2
12collagen fibril organizationGO:00301999.9TGFBR1, TGFB2, COL3A1
13negative regulation of transforming growth factor beta receptor signaling pathwayGO:00305129.9SMAD3, TGFBR1, TGFBR2
14response to mechanical stimulusGO:00096129.8COL3A1, IL6, TGFBR2
15activation of protein kinase activityGO:00321479.8TGFBR2, TGFB2
16lens development in camera-type eyeGO:00020889.7TGFBR1, TGFBR2
17skeletal system developmentGO:00015019.7FBN1, TGFBR1, MMP9, COL3A1
18agingGO:00075689.7TGFBR2, IL6, COL3A1
19protein phosphorylationGO:00064689.6TGFBR1, TGFBR2, TGFB2, MYLK
20cell cycle arrestGO:00070509.6TGFB2, TGFBR1, SMAD3
21positive regulation of epithelial to mesenchymal transitionGO:00107189.6TGFB2, SMAD3
22heart developmentGO:00075079.5COL3A1, TGFB2, TGFBR2, TGFBR1, FBN1
23proteolysisGO:00065089.5MMP1, MMP8, MMP2, MMP9
24response to hypoxiaGO:00016669.4SMAD3, TGFB2, MMP2
25positive regulation of cell proliferationGO:00082849.3TGFBR1, TGFBR2, TGFB2, IL6
26wound healingGO:00420609.3SMAD3, TGFBR1, TGFBR2, TGFB2, COL3A1
27transforming growth factor beta receptor signaling pathwayGO:00071799.3SMAD3, TGFBR1, TGFBR2, TGFB2, COL3A1
28collagen catabolic processGO:00305749.2MMP9, MMP2, MMP8, MMP1, COL3A1
29extracellular matrix disassemblyGO:00226178.8COL3A1, FBN1, MMP9, MMP2, MMP8, MMP1
30extracellular matrix organizationGO:00301988.4FBN1, TGFB2, MMP9, MMP2, MMP8, MMP1

Molecular functions related to Aortic Aneurysm according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:005043110.0TGFBR2, TGFBR1
2SMAD bindingGO:00463329.9COL3A1, TGFBR2, TGFBR1
3type II transforming growth factor beta receptor bindingGO:00051149.8TGFB2, TGFBR1
4extracellular matrix structural constituentGO:00052019.8FBN1, ELN, COL3A1
5transforming growth factor beta-activated receptor activityGO:00050249.7TGFBR2, TGFBR1
6transforming growth factor beta receptor bindingGO:00051609.5TGFB2, SMAD3
7metalloendopeptidase activityGO:00042229.3MMP1, MMP8, MMP2, MMP9
8protein bindingGO:00055156.9TGFB2, TGFBR2, TGFBR1, FBN1, SMAD3, MYLK

Products for genes affiliated with Aortic Aneurysm

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Sources for Aortic Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet