MCID: ART016
MIFTS: 62

Aortic Aneurysm malady

Summaries for Aortic Aneurysm

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 An aneurysm is a bulge or "ballooning" in the wall of an artery. arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. if an aneurysm grows large, it can burst and cause dangerous bleeding or even death. most aneurysms are in the aorta, the main artery that runs from the heart through the chest and abdomen. there are two types of aortic aneurysm: thoracic aortic aneurysms - these occur in the part of the aorta running through the chest abdominal aortic aneurysms - these occur in the part of the aorta running through the abdomen most aneurysms are found during tests done for other reasons. some people are at high risk for aneurysms. it is important for them to get screening, because aneurysms can develop and become large before causing any symptoms screening is recommended for people between the ages of 65 and 75 if they have a family history, or if they are men who have smoked. doctors use imaging tests to find aneurysms. medicines and surgery are the two main treatments. nih: national heart, lung, and blood institute

MalaCards: Aortic Aneurysm is related to abdominal aortic aneurysm and thoracic aortic aneurysm. An important gene associated with Aortic Aneurysm is ACTA2 (actin, alpha 2, smooth muscle, aorta), and among its related pathways are Integrin Pathway and Rho Family GTPases. The drug trimethaphan camsylate and the compounds serine and vegf have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and lung, and related mouse phenotypes are homeostasis/metabolism and immune system.

CDC:3 An aortic aneurysm is a balloon-like bulge in the aorta, the large artery that carries blood from the heart through the chest and torso.

Wikipedia:63 An aortic aneurysm is a general term for an enlargement (dilation) of the aorta to greater than 1.5... more...

Aliases & Classifications for Aortic Aneurysm

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

aortic aneurysm 8 10 33 60


External Ids:

Disease Ontology8 DOID:3627
NCIt39 C26697
MeSH34 D001014

Related Diseases for Aortic Aneurysm

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17GeneCards, 18GeneDecks
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Diseases related to Aortic Aneurysm via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1abdominal aortic aneurysm32.3MMP9
2thoracic aortic aneurysm32.0TGFBR2, ELN, MMP1, MMP2, MYH11, FBN1
3dissecting aortic aneurysm31.8ELN
4aneurysm disease31.5TGFBR2, ELN, ELANE, MMP9, MMP12, MMP8
5aortic disease31.4FBN1, ELN
6marfan syndrome31.1COL3A1, FBN1, ELN, TGFBR2, TGFBR1
7hypertension30.9MMP9
8atherosclerosis30.7FBN1, MYH11, MMP2, MMP8, MMP12, MMP1
9loeys-dietz syndrome30.7COL3A1, FBN1, ACTA2, TGFBR2, TGFBR1
10coronary artery disease30.6COL3A1, FBN1, MMP12, MMP9
11pancreatitis30.6ELANE
12vascular disease30.5MMP9, ELANE, ELN, TGFBR1
13ehlers-danlos syndrome30.5COL3A1, FBN1, ELN
14intracranial aneurysm30.5ELN, ELANE, COL3A1
15pneumonia30.5ELANE, MMP12, MMP8
16aortic valve stenosis30.4ELN
17myocardial infarction30.4COL3A1
18arteriosclerosis30.4ELN
19thoracic aortic aneurysms and aortic dissections30.3TGFBR1, TGFBR2, ACTA2, MYH11
20ehlers-danlos syndrome type iv30.3COL3A1, ELN
21lung cancer30.3MMP2, MMP1, MMP9, TGFBR2
22osteoarthritis30.2MMP2, MMP8, MMP12, MMP1, MMP9
23cutis laxa30.2FBN1, ELANE, ELN
24peritonitis30.2COL3A1, MMP8
25acute myocardial infarction30.2MMP9, MMP8
26colon cancer30.2MMP2, MMP9, SMAD3, TGFBR2, TGFBR1
27diabetes mellitus30.2MMP9
28gallbladder cancer30.2TGFBR2
29supravalvular aortic stenosis30.2FBN1, ELN
30connective tissue disease30.2FBN1
31colorectal cancer30.2TGFBR2, MMP9, MMP1, MMP2
32hepatocellular carcinoma29.9FBN1, MMP2, MMP12, MMP9, SMAD3, ELANE
33squamous cell carcinoma29.9MMP2, MMP12, MMP1, MMP9, SMAD3, TGFBR2
34rheumatoid arthritis29.9MMP2, MMP8, MMP12, MMP1, MMP9, ELANE
35pulmonary emphysema29.9MMP8, MMP12, MMP1, MMP9, ELANE, ELN
36arthritis29.9FBN1, MMP2, MMP8, MMP12, MMP1, MMP9
37exfoliation syndrome29.9FBN1, MMP1, ELN
38bladder carcinoma29.9MMP2, MMP12, MMP9, TGFBR1
39pneumothorax29.9COL3A1
40mitral valve prolapse29.9FBN1
41alpha 1-antitrypsin deficiency29.9ELANE
42leukemia29.9MYH11, SMAD3, TGFBR1
43pseudoxanthoma elasticum29.9FBN1, ELN
44transitional cell carcinoma29.9TGFBR1, TGFBR2, MMP9
45acute pancreatitis29.9ELANE
46ruptured aortic aneurysm11.4
47ruptured abdominal aortic aneurysm11.3
48ruptured thoracic aortic aneurysm10.9
49ischemia10.8
50familial thoracic aortic aneurysm and dissection10.7

Graphical network of the top 20 diseases related to Aortic Aneurysm:



Diseases related to aortic aneurysm

Clinical Features for Aortic Aneurysm

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Drugs & Therapeutics for Aortic Aneurysm

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Aortic Aneurysm

Drug clinical trials:

Search ClinicalTrials for Aortic Aneurysm

Search NIH Clinical Center for Aortic Aneurysm

Search CenterWatch for Aortic Aneurysm

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Aortic Aneurysm

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Anatomical Context for Aortic Aneurysm

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32MalaCards
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MalaCards organs/tissues related to Aortic Aneurysm:

32
Kidney, Heart, Lung, Spinal cord, Testes, Smooth muscle, Colon, Endothelial, Monocytes, T cells, Small intestine, Thyroid, Brain, Liver, Bone, Myeloid, Whole blood, Pituitary, Trachea

Animal Models for Aortic Aneurysm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Aortic Aneurysm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.7MYLK, TGFBR1, TGFBR2, ELN, ELANE, MYH11
2MP:000538711.4MMP12, TGFBR1, TGFBR2, ELANE, SMAD3, MMP9
3MP:001076811.4MMP2, MMP9, SMAD3, FBN1, COL3A1, MYLK
4MP:000536911.4MYLK, MMP2, MMP9, ELN, TGFBR2, MYH11
5MP:000538511.4TGFBR1, FBN1, MYLK, MYH11, MMP12, ACTA2
6MP:000200611.2TGFBR2, ELANE, TGFBR1, MMP9, MMP8, MMP2
7MP:000538811.2TGFBR1, MMP2, COL3A1, MMP9, ELN, TGFBR2
8MP:001077111.2TGFBR1, SMAD3, MMP9, COL3A1, FBN1, MYH11
9MP:000539010.6FBN1, SMAD3, MYLK, TGFBR1

Publications for Aortic Aneurysm

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50PubMed
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Articles related to Aortic Aneurysm:

(show top 50)    (show all 2866)
idTitleAuthorsYear
1
Efficacy of contrast-enhanced ultrasonography in detecting graft rupture sites after abdominal aortic aneurysm repair. (24218495)
2014
2
Successful use of talc sclerodesis to control a persistent high-output groin seroma following endovascular abdominal aortic aneurysm repair. (23711974)
2013
3
Late open conversion after failed endovascular aortic aneurysm repair. (24139568)
2013
4
Sherlock Holmes and Doctor Watson in scarlet: the fatal role of an aortic aneurysm. (23890911)
2013
5
Neisseria sicca Endocarditis Complicated by Intracranial and Popliteal Aneurysms in a Patient with a Bicuspid Aortic Valve. (23476838)
2013
6
Colorectal cancer associated with abdominal aortic aneurysm Results of EVAR followed by colectomy. (23151840)
2013
7
Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model. (23731681)
2013
8
Combined Cathepsin S and hs-CRP predicting inflammation of abdominal aortic aneurysm. (23742758)
2013
9
Automatic identification and validation of planar collagen organization in the aorta wall with application to abdominal aortic aneurysm. (24016340)
2013
10
Comparison of Endovascular and Open Repair of Ruptured Abdominal Aortic Aneurysm in the United States in the Past Decade. (23756880)
2013
11
Endovascular repair of delayed para-anastomotic pseudoaneurysm after open abdominal aortic aneurysm repair: a relatively simple technique for successful repair of a potentially catastrophic complication. (23896235)
2013
12
To use or not to use heparin during abdominal aortic aneurysm repair? (22841359)
2012
13
Iliac branched device implantation in tortuous iliac anatomy after previous open ruptured aortic aneurysm repair. (21769082)
2012
14
Cost effectiveness of abdominal aortic aneurysm screening and rescreening in men in a modern context: evaluation of a hypothetical cohort using a decision analytical model. (22767630)
2012
15
A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm. (20889295)
2011
16
Image diagnosis: thoracic aortic dissection and thoracic aortic aneurysm. (21841932)
2011
17
A case of incidentally detected IgG4-related sclerosing disease involving inflammatory abdominal aortic aneurysm and autoimmune pancreatitis. (20157837)
2010
18
The activity of class I, II, III and IV of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in the wall of abdominal aortic aneurysms. (19332052)
2009
19
Wegener's granulomatosis presenting as an abdominal aortic aneurysm: a case report. (20066062)
2009
20
Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: evidence for defective collagen type III. (18044709)
2008
21
Role of the Hardman index in predicting mortality for open and endovascular repair of ruptured abdominal aortic aneurysm. (17696628)
2007
22
Decrease of mortality of ruptured abdominal aortic aneurysm after centralization and in-hospital quality improvement of vascular service. (17521873)
2007
23
Pituitary apoplexy after aortic abdominal aneurysm surgery: a case report. (16612920)
2006
24
The candidate gene approach to susceptibility for abdominal aortic aneurysm: TIMP1, HLA-DR-15, ferritin light chain, and collagen XI-Alpha-1. (17182944)
2006
25
Thoracic aortic aneurysm with aortobronchial fistula: a thirteen-year experience. (15024377)
2004
26
Problems and prospects of managing thoracic aortic aneurysm at the Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. (14961193)
2004
27
Sudden death caused by dissecting thoracic aortic aneurysm in a patient with autosomal dominant polycystic kidney disease. (15451591)
2004
28
Short-term predictors and long-term outcome after ruptured abdominal aortic aneurysm repair. (12953829)
2003
29
Total arch replacement for thoracic aortic aneurysm via median sternotomy with or without left anterolateral thoracotomy. (12822617)
2003
30
Subannular left ventricular aneurysm in a patient with bicuspid aortic valve stenosis. (12478821)
2002
31
Coronary artery aneurysm and type-A aortic dissection demonstrated by retrospectively ECG-gated multislice spiral CT. (11868099)
2002
32
Thoracic aortic aneurysm repair: improvement in operative results and its background. (11398776)
2001
33
High prevalence of mild hyperhomocysteinemia in patients with abdominal aortic aneurysm. (10957660)
2000
34
Special cerebral perfusion in surgery for the ruptured thoracic aortic aneurysm. (10522790)
1999
35
MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial. (10415728)
1999
36
Ruptured abdominal aortic aneurysm: initial misdiagnosis and the effect on treatment. (9537706)
1998
37
Chronic contained rupture of an abdominal aortic aneurysm complicated by infection and femoral neuropathy. Case report. (8519880)
1995
38
Acute renal failure secondary to rhabdomyolysis associated with dissecting aortic aneurysm. (2800842)
1989
39
Ruptured abdominal aortic aneurysm: mortality, prognostic factors, and long-term survival. (3400253)
1988
40
Cardiac rupture, abdominal aneurysmal rupture and dissecting aortic rupture: a preventive trio. (3962881)
1986
41
Ruptured abdominal aortic aneurysm associated with an aorto-enteric fistula. A case report. (6879366)
1983
42
Doppler pulse waveform analysis of carotid artery flow in dissecting aortic aneurysm. (7213150)
1981
43
Indication of dissecting aortic aneurysm on noncontrast computed tomography. (7354163)
1980
44
Thoracic aortic aneurysm: natural history and treatment. (7359927)
1980
45
Balloon catheter contol of a ruptured abdominal aortic aneurysm in a patient with Cullen's sign. (647203)
1978
46
The clinical recognition of dissecting aortic aneurysm. (1020750)
1976
47
Letter: Dissecting aortic aneurysm diagnosed by echocardiography. (4441456)
1974
48
Ruptured abdominal aortic aneurysm presenting with peripheral neuropathy. (4360548)
1974
49
Supravalvular aortic stenosis associated with aortic aneurysm. (5108965)
1971
50
A case study: excision of descending thoracic aortic aneurysm and graft. (5201772)
1970

Genetic Variations for Aortic Aneurysm

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Expression for genes affiliated with Aortic Aneurysm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aortic Aneurysm

Search GEO for disease gene expression data for Aortic Aneurysm.

Pathways for genes affiliated with Aortic Aneurysm

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51QIAGEN, 53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 4Cell Signaling Technology, 59Tocris Bioscience
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Pathways related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4COL3A1, FBN1, MYLK, MYH11, MMP2, MMP8
2
Hide members
11.3COL3A1, FBN1, MYLK, MYH11, ACTA2, ELN
3
Hide members
11.2MMP2, MMP8, MMP12, MMP1, MMP9, ACTA2
4
Hide members
11.1COL3A1, FBN1, MMP2, MMP8, MMP12, MMP1
5
Cell adhesion ECM remodeling
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11.1ELN, COL3A1, MMP2, MMP8, MMP12, MMP1
611.1MMP2, MMP1, MMP9, SMAD3, TGFBR2, TGFBR1
7
Hide members
11.0TGFBR1, TGFBR2, ACTA2, MYH11, MYLK
8
Hide members
11.0TGFBR1, ACTA2, MMP9, MMP2, MYLK
9
Hide members
11.0MMP2, MMP8, MMP12, MMP1, MMP9
10
Hide members
10.9COL3A1, FBN1, ACTA2, TGFBR1
11
Transcription Androgen Receptor nuclear signaling
Hide members
10.9MMP2, SMAD3, TGFBR2, TGFBR1
1210.9MMP12, MMP1, TGFBR2, TGFBR1
13
Hide members
10.9COL3A1, MMP2, MMP8, MMP12
14
Cell adhesion Cell-matrix glycoconjugates
Hide members
10.9MMP1, MMP9, ELANE, ELN
1510.8ACTA2, TGFBR2, TGFBR1
16
Hide members
10.8TGFBR1, TGFBR2, ELN
1710.8SMAD3, TGFBR2, TGFBR1
1810.8SMAD3, TGFBR2, TGFBR1
19
Hide members
10.8TGFBR1, TGFBR2, SMAD3
2010.8TGFBR1, TGFBR2, SMAD3
21
Hide members
10.8TGFBR1, TGFBR2, SMAD3
22
Development TGF-beta receptor signaling
Hide members
10.8TGFBR1, TGFBR2, SMAD3
2310.8TGFBR1, TGFBR2, SMAD3
24
Hide members
10.8SMAD3, TGFBR2, TGFBR1
2510.8TGFBR1, TGFBR2, SMAD3
26
Cytokine production by Th17 cells in CF (Mouse model)
10.8SMAD3, TGFBR2, TGFBR1
27
Hide members
10.8MYLK, MYH11, ACTA2
2810.8MMP2, MMP9, TGFBR1
2910.8MMP2, MMP1, MMP9
3010.8MMP2, MMP9, SMAD3
3110.8MMP2, MMP9, ELANE
32
Hide members
10.7TGFBR1, TGFBR2
33
Hide members
10.7TGFBR1, TGFBR2
3410.7TGFBR1, TGFBR2
35
Hide members
10.7TGFBR1, TGFBR2
36
Hide members
10.7TGFBR2, TGFBR1
37
Hide members
10.7TGFBR2, TGFBR1
38
Hide members
10.7ELN, ELANE
39
Hide members
10.7ELANE, MMP9
4010.6SMAD3

Compounds for genes affiliated with Aortic Aneurysm

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank
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Compounds related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1serine4411.9ELN, MMP9, TGFBR1, MMP1, MMP12, MMP2
2vegf4411.9ELN, MMP1, TGFBR2, TGFBR1, MMP12, MMP8
3retinoic acid44 2412.9TGFBR1, TGFBR2, ELANE, MMP9, MMP1, MMP8
4alanine4411.7TGFBR1, FBN1, ELN, TGFBR2, MYLK, SMAD3
5tgf beta14411.7MMP1, FBN1, TGFBR1, TGFBR2, ELN, MMP2
6cysteine4411.5ELANE, TGFBR2, ELN, MMP9, MMP1, MMP8
7genistein44 28 59 2 11 2416.5MMP12, TGFBR1, ELN, MMP9, MMP1, MMP8
8batimastat44 59 1113.5MMP8, MMP2, MMP12, MMP1, MMP9, ELANE
9progesterone44 59 28 11 2415.5TGFBR2, MMP1, MMP8, MYH11, FBN1, TGFBR1
10hyaluronic acid44 2412.5ELN, ELANE, MMP9, MMP1, MMP2, FBN1
11matrigel4411.4SMAD3, MMP9, MMP1, MMP12, MMP2, TGFBR1
12ribonucleic acid4411.4MMP2, MMP1, TGFBR2, TGFBR1, MMP9, COL3A1
13n acetylcysteine4411.4ELN, SMAD3, MMP12, MMP9, MMP2, MMP1
14uk 3833675911.4MMP8, MMP2, MMP9, MMP1, MMP12
15gm 60015911.4MMP1, MMP9, MMP12, MMP8, MMP2
16gi 254023x5911.4MMP12, MMP2, MMP9, MMP1, MMP8
17ly2940024411.4MMP2, MMP9, TGFBR2, TGFBR1, MYH11, SMAD3
18hydroxamate4411.4MMP9, MMP12, MMP8, MMP2, MMP1
19marimastat44 59 1113.4MMP12, MMP9, MMP2, MMP8, MMP1
20hydroxyproline44 11 2413.4ELN, MMP9, MMP1, MMP2, FBN1
21paraffin4411.4TGFBR1, ELN, MMP2, MMP1, MMP9, MYH11
22tetracycline44 1112.3MMP2, MMP8, MMP1, TGFBR2, MMP9
23cytochalasin d44 5912.3MMP1, MYLK, MMP2, MMP9, ACTA2
24ilomastat4411.3ELANE, MMP9, MMP1, MMP2
25cilomilast4411.3MMP9, MMP2, MMP1, ELANE
26lactate4411.3MMP8, MMP2, MMP1, MMP9, ELN, ELANE
27cyclosporin a44 28 5913.2COL3A1, MMP8, MMP1, ELANE, TGFBR2
28zinc44 2412.2MMP1, SMAD3, MMP9, MMP2, MMP8, MMP12
29doxycycline44 1112.2MMP8, MMP1, ELANE
30cgs-27023a4411.2MMP1, MMP2, MMP9
31vgvapg4411.2ELN, MMP1, MMP2
32nitric oxide44 11 2413.2MYLK, MMP12, SMAD3, TGFBR2, TGFBR1, MMP8
33desmosine4411.1FBN1, ELN, ELANE
34prinomastat4411.1MMP2, MMP1, MMP9
35(4-aminophenyl)mercuric acetate4411.1MMP8, ELANE
36vitamin a44 11 2413.1ELANE, MMP1, MMP9, MMP2
37gelfoam4411.1ELN, MMP2, MMP9
38latanoprost44 1112.1MMP9, MMP1, MMP2
39hematoxylin4411.0ELN, MMP1, MYH11
40bleomycin44 1112.0SMAD3, TGFBR2, ELN, MMP9
41estrogen4411.0ELN
42aprotinin44 1112.0MMP9, MMP1, MMP2, ELANE
43glutamate4410.9FBN1
44cycloheximide4410.9ELN
45cacl24410.9ELN, MMP8, FBN1
46pge24410.9MMP2, MMP9
47thermolysin4410.9ELN, ELANE
48glycosaminoglycan4410.8ELN, MMP9, MMP8, MMP1
49METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID1110.7MMP1, MMP8
50sodium dodecylsulfate4410.5ELN, ELANE, FBN1

GO Terms for genes affiliated with Aortic Aneurysm

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16Gene Ontology
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Cellular components related to Aortic Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3ELN, COL3A1, FBN1, ELANE, MMP9, MMP1
2proteinaceous extracellular matrixGO:00557811.2MMP1, FBN1, MMP2, MMP8, MMP12, MMP9
3smooth muscle contractile fiberGO:03048510.7MYH11, ACTA2
4receptor complexGO:04323510.7SMAD3, TGFBR1, TGFBR2
5transforming growth factor beta receptor homodimeric complexGO:07002210.4TGFBR1, TGFBR2

Biological processes related to Aortic Aneurysm according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019811.6COL3A1, FBN1, MMP2, MMP8, MMP12, MMP1
2collagen catabolic processGO:03057411.4ELANE, COL3A1, MMP2, MMP8, MMP12, MMP1
3extracellular matrix disassemblyGO:02261711.4COL3A1, MMP2, MMP8, MMP12, MMP1, MMP9
4proteolysisGO:00650811.3MMP2, MMP8, MMP12, MMP1, MMP9, ELANE
5wound healingGO:04206011.1COL3A1, SMAD3, TGFBR2, TGFBR1
6transforming growth factor beta receptor signaling pathwayGO:00717911.0COL3A1, SMAD3, TGFBR2, TGFBR1
7skeletal system developmentGO:00150111.0TGFBR1, MMP9, FBN1, COL3A1
8embryonic cranial skeleton morphogenesisGO:04870111.0TGFBR1, TGFBR2, SMAD3
9heart developmentGO:00750710.9TGFBR1, TGFBR2, FBN1, COL3A1
10embryo implantationGO:00756610.9MMP2, MMP9, TGFBR2
11response to cholesterolGO:07072310.7TGFBR1, TGFBR2
12pathway-restricted SMAD protein phosphorylationGO:06038910.7TGFBR1, TGFBR2
13negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.7SMAD3, TGFBR2, TGFBR1
14muscle contractionGO:00693610.5ACTA2, MYH11, MYLK

Molecular functions related to Aortic Aneurysm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422211.1MMP9, MMP1, MMP12, MMP8, MMP2
2SMAD bindingGO:04633210.8TGFBR1, COL3A1, TGFBR2
3extracellular matrix structural constituentGO:00520110.8ELN, FBN1, COL3A1
4transforming growth factor beta-activated receptor activityGO:00502410.7TGFBR1, TGFBR2
5transmembrane receptor protein serine/threonine kinase activityGO:00467510.6TGFBR2, TGFBR1
6transforming growth factor beta bindingGO:05043110.4TGFBR1, TGFBR2

Products for genes affiliated with Aortic Aneurysm

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  • Antibodies
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Sources for Aortic Aneurysm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet