MCID: ART004
MIFTS: 51

Aortic Atherosclerosis malady

Cardiovascular category

Summaries for Aortic Atherosclerosis

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33MalaCards
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MalaCards: Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to atherosclerosis and aortic disease. An important gene associated with Aortic Atherosclerosis is GLA (galactosidase, alpha), and among its related pathways are Trafficking of dietary sterols and Golgi to ER Retrograde Transport. The compounds rosiglitazone and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and heart, and related mouse phenotypes are other and adipose tissue.

Aliases & Classifications for Aortic Atherosclerosis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

aortic atherosclerosis 8 10
atherosclerosis of aorta 8 61


External Ids:

Disease Ontology8 DOID:10230
ICD9CM27 440.0
ICD1025 I70.0

Related Diseases for Aortic Atherosclerosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis31.8CETP, SCARB1, LCAT, TLR4, SPP1, PLA2G7
2aortic disease30.9LDLR, APOE
3coronary artery disease,30.7LDLR, CETP, PLA2G7, ABCA1, LRP1, LIPC
4stroke, ischemic30.5F5, APOE, LPA, PLA2G7
5hypercholesterolemia30.4LDLR, CETP, PLA2G7, ABCA1, ABCG5, ABCG8
6familial hypercholesterolemia30.2CETP, LDLR
7cholelithiasis30.0ABCG8, SCARB1, ABCG5
8amyloidosis30.0LRP1, LPL, APOE, LPA
9cystic fibrosis30.0ABCA1, MPO, TLR4, LPL
10systemic lupus erythematosus30.0TLR4, MPO, PLA2G7, SPP1
11insulin resistance30.0LIPC, LPL, LPA, SCARB1, TLR4, LCAT
12vascular disease30.0LRP1, LIPC, F5, LPL, LPA, APOE
13cerebral atherosclerosis10.3
14patent foramen ovale10.2
15aortic valve stenosis10.2
16aortic valve disease10.2
17aortitis10.1
18diabetic nephropathy10.0
19portal hypertension10.0
20dissecting aortic aneurysm10.0
21n syndrome10.0
22hypertensive retinopathy10.0
23aortic aneurysm10.0
24al amyloidosis10.0
25amyloidosis cerebral10.0
26aortic coarctation10.0
27bacteremia10.0
28pulmonary disease, chronic obstructive10.0
29lipoprotein lipase deficiency10.0LPL
30abdominal aortic aneurysm10.0APOE
31viral hepatitis10.0LCAT
32lipoprotein glomerulopathy10.0APOE
33malaria10.0SCARB1
34hepatitis10.0LDLR
35pick's disease10.0APOE
36peritonitis10.0MPO
37ischemia10.0MPO
38periodontitis10.0TLR4
39fabry disease10.0GLA
40hyperthyroidism10.0LDLR
41migraine10.0LDLR
42vasculitis10.0MPO
43myeloperoxidase deficiency10.0MPO
44myeloma10.0SPP1
45protein s deficiency10.0F5
46acute myocardial infarction10.0LPA, LCAT
47lupus erythematosus10.0F5
48dilated cardiomyopathy10.0LPL, PLA2G7
49lipodystrophy10.0LDLR, LPL
50sarcoma10.0LDLR

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to aortic atherosclerosis

Clinical Features for Aortic Atherosclerosis

Drugs & Therapeutics for Aortic Atherosclerosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Aortic Atherosclerosis

Drug clinical trials:

Search ClinicalTrials for Aortic Atherosclerosis

Search NIH Clinical Center for Aortic Atherosclerosis

Search CenterWatch for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

Anatomical Context for Aortic Atherosclerosis

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Aortic Atherosclerosis:

33
Liver, Kidney, Heart, Smooth muscle, Pancreas, Monocytes, B cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
id TissueAnatomical CompartmentCell Relevance
1 HeartAortic Arch ArteriesVascular Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Animal Models for Aortic Atherosclerosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Aortic Atherosclerosis

Sources:
51PubMed
See all sources

Articles related to Aortic Atherosclerosis:

(show top 50)    (show all 322)
idTitleAuthorsYear
1
Effect of age on aortic atherosclerosis. (23888172)
2013
2
Association of resting heart rate with carotid and aortic arterial stiffness: multi-ethnic study of atherosclerosis. (23836802)
2013
3
Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. (23451182)
2013
4
Transcatheter aortic valve implantation with "no touch" of the aortic arch for the treatment of severe aortic stenosis associated with complex aortic atherosclerosis. (20626520)
2010
5
Predisposition to atherosclerosis and aortic aneurysms in mice deficient in kinin B1 receptor and apolipoprotein E. (19618151)
2009
6
Amounts of aortic atherosclerosis in patients with aortic stenosis as determined by transesophageal echocardiography. (19231339)
2009
7
Comparison of coronary flow velocity reserve and aortic distensibility in diabetic versus non-diabetic patients with and without aortic atherosclerosis. (18328589)
2008
8
Aortic atherosclerosis, hypercoagulability, and stroke the APRIS (Aortic Plaque and Risk of Ischemic Stroke) study. (18755350)
2008
9
Experimentally induced metabolic acidosis in rabbits modulates the interaction of aortic glycosaminoglycan with plasma low-density lipoprotein--an interesting observation about the association of acidosis and atherosclerosis. (17056046)
2007
10
Relationship between aortic atherosclerosis and non-invasive measures of arterial stiffness. (17678931)
2007
11
The evaluation of aortic atherosclerosis and distensibility in aortic valve stenosis--the role of transesophageal echocardiography. (16256821)
2005
12
Comparison of coronary and aortic atherosclerosis in youth from Japan and the USA. (15823290)
2005
13
Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs. (15845905)
2005
14
Prevalence and significance of renal artery stenosis and abdominal aortic atherosclerosis early after heart transplantation. (12493431)
2002
15
Transdermal estrogens do not appear to modify the extent of lesional areas of aortic atherosclerosis in oophorectomized rabbits on a cholesterol-rich diet. (10657566)
2000
16
Independent association of high blood pressure and aortic atherosclerosis: A population-based study. (11044425)
2000
17
Cystatin C deficiency in human atherosclerosis and aortic aneurysms. (10545518)
1999
18
Analysis of secretory group II phospholipase A2 expression in human aortic tissue in dependence on the degree of atherosclerosis. (10381280)
1999
19
Immunization with bacillus Calmette-Guerin vaccine increases aortic atherosclerosis in the cholesterol-fed rabbit. (10208485)
1999
20
Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice. (10601244)
1999
21
Aortic sinotubular junction calcium as a marker of severe aortic atherosclerosis. (9874068)
1998
22
Surface features of human aortic atherosclerosis as seen with scanning electron microscopy. (9821792)
1998
23
Oxidized cholesterol in the diet accelerates the development of aortic atherosclerosis in cholesterol-fed rabbits. (9633940)
1998
24
Relative resistance of the hamster to aortic atherosclerosis in spite of prolonged vitamin E deficiency and dietary hypercholesterolemia. Putative effect of increased HDL? (8555267)
1996
25
Relation between aortic atherosclerosis and blood pressure. (7911961)
1994
26
Cytokine gene expression in aortic adventitial inflammation associated with advanced atherosclerosis (chronic periaortitis). (7962625)
1994
27
Influx, efflux, and accumulation of LDL in normal arterial areas and atherosclerotic lesions of white Carneau pigeons with naturally occurring and cholesterol-aggravated aortic atherosclerosis. (8364021)
1993
28
Dexamethasone-induced suppression of aortic atherosclerosis in cholesterol-fed rabbits. Possible mechanisms. (8499410)
1993
29
Age-dependent increase of rabbit aortic atherosclerosis. A morphometric approach. (1409103)
1992
30
Suppression of aortic atherosclerosis in cholesterol-fed rabbits by purified rabbit interferon. (1690536)
1990
31
Promotive effect of elastase on regression of aortic atherosclerosis in cholesterol-fed quails. (2767211)
1989
32
Influence of hypertension on aortic atherosclerosis in the Watanabe rabbit. (2759679)
1989
33
Ultrastructural and elemental analysis of calcification of advanced swine aortic atherosclerosis. (4065312)
1985
34
Hemodynamic modification of aortic atherosclerosis. Effects of propranolol vs hydralazine in hypertensive hyperlipidemic rabbits. (6712777)
1984
35
Aortic atherosclerosis in nonlaying hens with fatty liver syndrome. (6639549)
1983
36
Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. (6870991)
1983
37
Spontaneous aortic atherosclerosis in cattle. (6773267)
1980
38
Diet-induced aortic atherosclerosis in Malaysian long-tailed monkeys (Macaca irus). (1151525)
1975
39
Blood lipid levels in pigs & their possible role in the development of aortic atherosclerosis. (4783392)
1973
40
Application of point-counting technique to the quantitative assessment of coronary and aortic atherosclerosis. (5045419)
1972
41
Studies on the incidence of aortic atherosclerosis in Indore. (5505639)
1970
42
Aortic atherosclerosis in hoofed mammals. (5813620)
1969
43
Coronary and aortic atherosclerosis. (A study on 300 medicolegal postmortems). (5783200)
1969
44
Relation between aortic atherosclerosis and the use of cigarettes and alcohol. An autopsy study. (5722916)
1968
45
PROBLEMS CONCERNING THE DEFINITION AND GRADING OF THE AORTIC ATHEROSCLEROSIS. (14162802)
1964
46
DEVELOPMENTAL PATTERNS OF CORONARY AND AORTIC ATHEROSCLEROSIS IN YOUNG NEGROES OF HAITI AND THE UNITED STATES. (14233811)
1964
47
LIPID-BINDING CAPACITY OF INTIMAL GLOBULINS IN HUMAN AORTIC ATHEROSCLEROSIS. (14226167)
1964
48
INCIDENCE OF DISEASE IN THE NAVAJO INDIAN. A NECROPSY STUDY OF CORONARY AND AORTIC ATHEROSCLEROSIS, CHOLELITHIASIS, AND NEOPLASTIC DISEASE. (14120694)
1964
49
The incidence of acid-fast pigment (ceroid) in aortic atherosclerosis. (14902712)
1952
50
Absorption of aortic atherosclerosis by choline feeding. (18102203)
1948

Genetic Variations for Aortic Atherosclerosis

Expression for genes affiliated with Aortic Atherosclerosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for genes affiliated with Aortic Atherosclerosis

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 50PharmGKB
See all sources

Pathways related to Aortic Atherosclerosis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ABCG8, ABCG5
210.0CETP, ABCA1
3
Hide members
9.8ABCA1, ABCG5, ABCG8
4
Hide members
9.8APOE, SCARB1, LRP1
59.8LPA, CETP, LDLR
69.8GLA, LIPC, LPL
7
Hide members
9.8LDLR, LPL, SCARB1
89.8LPA, MPO, LRP1
99.7SCARB1, LPL, ABCG8, ABCG5
109.7LDLR, ABCG5, ABCG8, SCARB1
119.7ABCA1, MPO, SCARB1
129.6SCARB1, ABCG8, ABCG5, ABCA1
13
Hide members
9.6APOE, LPL, LRP1, LDLR
149.6LDLR, LRP1, APOE, TLR4
159.4SCARB1, MPO, ABCA1, LDLR
16
Hide members
9.3ABCG8, ABCG5, ABCA1, PLA2G7, CETP, LDLR
17
Hide members
9.0LCAT, APOE, SCARB1, LPA, LPL, LIPC
18
Hide members
8.4CETP, ABCA1, ABCG5, ABCG8, LPL, LPA
19
Hide members
8.1LDLR, LCAT, CETP, ABCA1, ABCG5, ABCG8

Compounds for genes affiliated with Aortic Atherosclerosis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Aortic Atherosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1rosiglitazone45 50 29 11 2414.3SCARB1, LRP1
2alpha tocopherol4510.0LCAT, LDLR, LPL, SCARB1
3lathosterol45 2411.0LDLR, ABCG8, APOE, CETP
4estrogen459.9LCAT, LPA, LIPC, CETP
5cholestyramine459.9LPA, CETP, LDLR, APOE
6sele459.9LPL, APOE, LDLR, CETP
7xbai459.9LDLR, LPL, APOE
8cyclosporin a45 29 6011.8LPL, LIPC, CETP, ABCA1
9intralipid459.8LIPC, LPL, APOE, LCAT, CETP
10dimyristoylphosphatidylcholine459.7LPA, APOE, LCAT, LDLR
11fluvastatin45 50 29 1112.6LDLR, CETP, PLA2G7, LPL, APOE
12ezetimibe45 1110.6ABCG8, CETP, LDLR, ABCG5, ABCA1, SCARB1
13psyllium459.6LCAT, CETP, LDLR
14palmitate459.6CETP, APOE, LPL, LCAT, TLR4, LDLR
15lycopene45 2410.5SCARB1, LPL, CETP, LDLR
16gemfibrozil45 29 1111.5LDLR, CETP, LIPC, LPL, LPA, APOE
17niacin45 1110.5CETP, LDLR, ABCA1, LPL, LPA, SCARB1
18pravastatin45 50 29 11 2413.5APOE, LCAT, CETP, ABCA1, LPA, LDLR
19aspartate459.5LRP1, GLA, APOE, LDLR, CETP, SPP1
20dextran sulfate459.4F5, CETP, LDLR, LPL, MPO
21glucose459.4LPA, GLA, ABCA1, PLA2G7, LRP1, SCARB1
22hind iii459.4ABCA1, LIPC, F5, LPL, LPA
23triacylglycerol459.4PLA2G7, LIPC, LPL, CETP, LCAT, LDLR
24thyroxine45 2410.3APOE, LDLR, LPL, LPA, CETP, LIPC
25lovastatin45 50 60 29 1113.3LIPC, LRP1, LDLR, CETP, LPA, LPL
26serine459.2LCAT, TLR4, MPO, LIPC, CETP, LDLR
27stearic acid45 11 2411.2ABCA1, LIPC, LPL, CETP, LDLR
28vitamin a45 11 2411.1LDLR, CETP, LPA, LIPC, APOE, LCAT
29probucol45 1110.1APOE, SCARB1, LPL, LIPC, LDLR, CETP
30carbohydrates459.1TLR4, CETP, LDLR, LRP1, LIPC, LPL
31bezafibrate45 29 1111.1LPA, LDLR, LCAT, APOE, LPL, LIPC
32oleic acid45 29 11 2412.0LRP1, PLA2G7, ABCA1, LPA, LDLR, CETP
33fenofibrate45 50 1111.0ABCA1, PLA2G7, CETP, LDLR, LIPC, LPL
34ascorbic acid45 2410.0LCAT, APOE, MPO, CETP, SPP1, F5
35sodium dodecylsulfate459.0CETP, LIPC, F5, LPL, LPA, APOE
36heparin45 29 11 2412.0LCAT, SPP1, LPA, LPL, MPO, LIPC
37fibrinogen458.8LIPC, ABCA1, SPP1, PLA2G7, TLR4, LPA
38aspirin45 50 29 2411.7LDLR, TLR4, APOE, SCARB1, LPA, F5
39sterol458.7LCAT, APOE, SCARB1, LIPC, LRP1, ABCG8
40fatty acid458.6LRP1, LIPC, LPL, LPA, SCARB1, LCAT
41simvastatin45 50 60 29 11 2413.6F5, LPL, LPA, SCARB1, ABCA1, LDLR
42nitric oxide45 11 2410.5PLA2G7, LRP1, MPO, ABCA1, SCARB1, GLA
43cholesterol ester458.5LDLR, LCAT, APOE, SCARB1, LPA, LPL
44testosterone45 60 11 2411.4F5, LDLR, LIPC, LPL, LCAT, APOE
45cysteine458.3LPA, F5, LRP1, SPP1, LCAT, TLR4
46phosphatidylcholine458.3LCAT, APOE, SCARB1, LPA, LPL, F5
47atorvastatin45 50 29 11 2412.1APOE, TLR4, LCAT, PLA2G7, CETP, LDLR
48phospholipid457.8LDLR, CETP, LCAT, TLR4, APOE, SCARB1
49lipid457.5LDLR, CETP, SPP1, PLA2G7, ABCA1, ABCG5
50cholesterol45 29 11 2410.3LIPC, LRP1, F5, LPL, LPA, SCARB1

GO Terms for genes affiliated with Aortic Atherosclerosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Aortic Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:04262710.1LPL, APOE
2low-density lipoprotein particleGO:0343629.9APOE, PLA2G7, LDLR
3high-density lipoprotein particleGO:0343649.7CETP, LIPC, APOE, LCAT
4extracellular spaceGO:0056158.6LCAT, APOE, LPL, F5, MPO, LIPC
5extracellular regionGO:0055768.5LCAT, APOE, LPA, LPL, F5, GLA
6plasma membraneGO:0058867.8TLR4, APOE, SCARB1, LPL, F5, LRP1

Biological processes related to Aortic Atherosclerosis according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of intestinal phytosterol absorptionGO:01094910.5ABCG5, ABCG8
2negative regulation of intestinal cholesterol absorptionGO:04579610.5ABCG5, ABCG8
3sterol transportGO:01591810.5ABCG5, ABCG8
4lipoprotein biosynthetic processGO:04215810.3APOE, LCAT
5regulation of phosphatidylcholine catabolic processGO:01089910.3LDLR, SCARB1
6detection of lipopolysaccharideGO:03249710.3SCARB1, TLR4
7lipoprotein catabolic processGO:04215910.3APOE, LDLR
8cholesterol importGO:07050810.3LDLR, SCARB1
9high-density lipoprotein particle clearanceGO:03438410.3APOE, SCARB1
10intestinal cholesterol absorptionGO:03029910.3LDLR, ABCG5, ABCG8
11regulation of Cdc42 protein signal transductionGO:03248910.2APOE, ABCA1
12positive regulation of cholesterol storageGO:01088610.2LPL, SCARB1
13cholesterol transportGO:03030110.2LDLR, CETP, LCAT
14high-density lipoprotein particle assemblyGO:03438010.2ABCA1, APOE
15triglyceride metabolic processGO:00664110.2APOE, LPL, CETP
16chylomicron remnant clearanceGO:03438210.2APOE, LIPC
17low-density lipoprotein particle clearanceGO:03438310.2LDLR, SCARB1
18positive regulation of cholesterol effluxGO:01087510.1APOE, LRP1, ABCA1
19phospholipid homeostasisGO:05509110.1ABCA1, CETP
20positive regulation of triglyceride biosynthetic processGO:01086710.1SCARB1, LDLR
21positive regulation of nitric-oxide synthase activityGO:05100010.1SCARB1, APOE
22phospholipid transportGO:01591410.0LDLR, CETP, ABCG8, SCARB1
23retinoid metabolic processGO:00152310.0APOE, LPL, LRP1, LDLR
24phospholipid effluxGO:03370010.0ABCA1, APOE
25phototransduction, visible lightGO:00760310.0APOE, LPL, LRP1, LDLR
26cholesterol catabolic processGO:00670710.0APOE, SCARB1
27triglyceride homeostasisGO:0703289.9SCARB1, LPL, LIPC, CETP
28very-low-density lipoprotein particle remodelingGO:0343729.8LCAT, APOE, LPL, LIPC, CETP
29cholesterol effluxGO:0333449.8APOE, SCARB1, ABCG8, ABCG5, ABCA1
30high-density lipoprotein particle remodelingGO:0343759.8CETP, LIPC, SCARB1, APOE, LCAT
31receptor-mediated endocytosisGO:0068989.8LDLR, CETP, LRP1, LPA, APOE
32low-density lipoprotein particle remodelingGO:0343749.7APOE, MPO, LIPC, PLA2G7, CETP
33negative regulation of macrophage derived foam cell differentiationGO:0107459.7CETP, ABCA1
34reverse cholesterol transportGO:0436919.5LCAT, APOE, SCARB1, LIPC, ABCA1, CETP
35cholesterol metabolic processGO:0082039.2LCAT, APOE, LIPC, LRP1, ABCA1, CETP
36lipoprotein metabolic processGO:0421579.1LCAT, APOE, SCARB1, LPA, LPL, ABCA1
37cholesterol homeostasisGO:0426328.9LDLR, LCAT, CETP, ABCA1, ABCG5, ABCG8
38small molecule metabolic processGO:0442818.6ABCG8, GLA, LPL, LPA, SCARB1, APOE

Molecular functions related to Aortic Atherosclerosis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1triglyceride bindingGO:01712910.2CETP, LPL
2lipid transporter activityGO:00531910.1CETP, APOE
3lipopolysaccharide receptor activityGO:00187510.1TLR4, SCARB1
4phospholipid transporter activityGO:00554810.0CETP, ABCA1
5apolipoprotein A-I bindingGO:03418610.0ABCA1, SCARB1, LCAT
6phospholipase activityGO:0046209.9LIPC, LPL
7low-density lipoprotein particle bindingGO:0301699.8LDLR, LIPC, SCARB1
8lipopolysaccharide bindingGO:0015309.7SCARB1, TLR4
9cholesterol transporter activityGO:0171279.7APOE, ABCG8, ABCG5, ABCA1, CETP
10heparin bindingGO:0082019.4APOE, LPA, LPL, MPO, LIPC
11apolipoprotein bindingGO:0341859.2ABCA1, LRP1, LIPC, LPL, LPA, SCARB1

Products for genes affiliated with Aortic Atherosclerosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aortic Atherosclerosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet