MCID: ART004
MIFTS: 45

Aortic Atherosclerosis malady

Cardiovascular diseases category
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Summaries for Aortic Atherosclerosis

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33MalaCards
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MalaCards: Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to atherosclerosis and coronary artery disease. An important gene associated with Aortic Atherosclerosis is ABCG5 (ATP-binding cassette, sub-family G (WHITE), member 5), and among its related pathways are ABC-family proteins mediated transport and Bile secretion. The compounds sitosterol and ceramide have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotype liver/biliary system.

Aliases & Classifications for Aortic Atherosclerosis

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8Disease Ontology, 10DISEASES, 62UMLS, 27ICD9CM, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

aortic atherosclerosis 8 10
atherosclerosis of aorta 8 62


External Ids:

Disease Ontology8 DOID:10230
ICD9CM27 440.0
ICD1025 I70.0

Related Diseases for Aortic Atherosclerosis

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17GeneCards, 18GeneDecks
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Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis31.6GLA, ABCG8, ABCG5, SCARB1, CETP, PLA2G7
2coronary artery disease30.7PLA2G7, CETP, SCARB1
3hypercholesterolemia30.4PLA2G7, CETP, ABCG5, ABCG8
4familial hypercholesterolemia30.3PLA2G7, CETP
5cholelithiasis30.1ABCG8, ABCG5, SCARB1
6insulin resistance30.0SCARB1, CETP, PLA2G7
7diabetes mellitus30.0PLA2G7, CETP, SCARB1
8artery disease10.5
9hypertension10.5
10cerebritis10.3
11patent foramen ovale10.2
12hepatitis10.2
13aortitis10.1
14sitosterolemia10.0ABCG8, ABCG5
15diabetic nephropathy10.0
16cystic fibrosis10.0
17portal hypertension10.0
18alzheimer's disease10.0
19hypertensive retinopathy10.0
20systemic lupus erythematosus10.0
21amyloidosis10.0
22aortic valve disease10.0
23aortic valve stenosis10.0
24ischemia10.0
25lupus erythematosus10.0
26multiple myeloma10.0
27myeloma10.0
28periodontal disease10.0
29periodontitis10.0
30pneumonia10.0
31aneurysm10.0
32bacteremia10.0
33endotheliitis10.0
34iga glomerulonephritis10.0GLA, PLA2G7
35hyperalphalipoproteinemia10.0CETP, SCARB1
36abetalipoproteinemia10.0CETP, PLA2G7
37congenital heart disease10.0GLA, CETP
38hypertriglyceridemia10.0PLA2G7, CETP
39nephrotic syndrome10.0PLA2G7, CETP
40familial hyperlipidemia10.0PLA2G7, CETP
41primary hyperoxaluria10.0GLA, CETP
42essential hypertension10.0PLA2G7, CETP
43type 1 diabetes mellitus10.0CETP, PLA2G7
44vascular disease10.0PLA2G7, CETP
45proteinuria9.9CETP, PLA2G7, GLA
46metabolic syndrome x9.9GLA, CETP
47chronic kidney failure9.9GLA, PLA2G7, CETP
48cerebrovascular disease9.9CETP, PLA2G7, GLA
49obesity9.9SCARB1, CETP, PLA2G7
50myocardial infarction9.9GLA, PLA2G7, CETP, SCARB1

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to aortic atherosclerosis

Symptoms for Aortic Atherosclerosis

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Drugs & Therapeutics for Aortic Atherosclerosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Aortic Atherosclerosis

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

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Anatomical Context for Aortic Atherosclerosis

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Aortic Atherosclerosis:

33
Heart, Kidney, Liver, Bone, Monocytes, Endothelial, Pancreas

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
id TissueAnatomical CompartmentCell Relevance
1 HeartAortic Arch ArteriesVascular Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Animal Models for Aortic Atherosclerosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Aortic Atherosclerosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6GLA, SCARB1, ABCG5, ABCG8

Publications for Aortic Atherosclerosis

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52PubMed
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Articles related to Aortic Atherosclerosis:

(show top 50)    (show all 275)
idTitleAuthorsYear
1
Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins. (23339166)
2013
2
Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. (24242683)
2013
3
Comprehensive evaluation of coronary artery disease and aortic atherosclerosis in acute ischemic stroke patients: usefulness based on Framingham risk score and stroke subtype. (21487225)
2011
4
In vivo knockdown of nicotinic acetylcholine receptor I+1 diminishes aortic atherosclerosis. (20810113)
2011
5
Premature aortic atherosclerosis in systemic lupus erythematosus: a controlled transesophageal echocardiographic study. (19955049)
2010
6
Amounts of aortic atherosclerosis in patients with aortic stenosis as determined by transesophageal echocardiography. (19231339)
2009
7
Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice. (19330073)
2008
8
Comparison of coronary flow velocity reserve and aortic distensibility in diabetic versus non-diabetic patients with and without aortic atherosclerosis. (18328589)
2008
9
Quantitative analysis of aortic atherosclerosis in Korean female: a necropsy study. (17596667)
2007
10
Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice. (16990555)
2006
11
The evaluation of aortic atherosclerosis and distensibility in aortic valve stenosis--the role of transesophageal echocardiography. (16256821)
2005
12
Role of calcium in the aortic atherosclerosis/stroke relation. (16360372)
2005
13
Effect of inhibitors of myeloperoxidase on the development of aortic atherosclerosis in an animal model. (15763397)
2005
14
Relationship between arterial stiffness and subclinical aortic atherosclerosis. (15262851)
2004
15
Indices of aortic distensibility and coronary flow velocity reserve in patients with different grades of aortic atherosclerosis. (15529908)
2004
16
The comparative value of the aortic atherosclerosis and the coronary flow velocity reserve evaluated by stress transesophageal echocardiography in the prediction of patients with aortic stenosis with coronary artery disease. (14609185)
2003
17
Update on imaging aortic atherosclerosis. (12760169)
2003
18
Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E-deficient mice. (12752312)
2003
19
Association of carotid artery intima-media thickness with complex aortic atherosclerosis in patients with recent stroke. (11952109)
2002
20
Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden. (11777225)
2001
21
Transesophageal magnetic resonance imaging of the aortic arch and descending thoracic aorta in patients with aortic atherosclerosis. (11419883)
2001
22
Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly. (10657417)
2000
23
Transdermal estrogens do not appear to modify the extent of lesional areas of aortic atherosclerosis in oophorectomized rabbits on a cholesterol-rich diet. (10657566)
2000
24
Craniocervical and aortic atherosclerosis as neurologic risk factors in coronary surgery. (10750769)
2000
25
Gender differences in response to a hypercholesterolemic diet in hamsters: effects on plasma lipoprotein cholesterol concentrations and early aortic atherosclerosis. (10487490)
1999
26
Aortic sinotubular junction calcium as a marker of severe aortic atherosclerosis. (9874068)
1998
27
Surface features of human aortic atherosclerosis as seen with scanning electron microscopy. (9821792)
1998
28
Aortic atherosclerosis and stroke. (17894983)
1997
29
Quantitative assessment of abdominal aortic atherosclerosis observed in CT scans. (9258596)
1997
30
Aortic atherosclerosis and perioperative stroke in patients undergoing coronary artery bypass: role of intra-operative transesophageal echocardiography. (9292329)
1997
31
Relationship of cigarette smoking to the severity of coronary and thoracic aortic atherosclerosis. (7585737)
1995
32
Relation between aortic atherosclerosis and blood pressure. (7911961)
1994
33
J-shaped relation between change in diastolic blood pressure and progression of aortic atherosclerosis. (7906758)
1994
34
In vitro characterization of two types of LDL apheresis module and effect of repetitive LDL apheresis on plasma cholesterol levels and aortic atherosclerosis in heterozygous WHHL rabbits. (2010950)
1991
35
Suppression of aortic atherosclerosis in cholesterol-fed rabbits by purified rabbit interferon. (1690536)
1990
36
Monocyte chemoattractants in pigeon aortic atherosclerosis. (3826301)
1987
37
Operative treatment of juxtarenal aortic atherosclerosis. (3868907)
1985
38
Aortic atherosclerosis in nonlaying hens with fatty liver syndrome. (6639549)
1983
39
Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. (6870991)
1983
40
Aortic atherosclerosis in hypertensive rabbits treated with anti-hypertensive agents having different effects on arterial flow disturbances. 1. Extent of surface involvement. (7347391)
1981
41
The effects of egg yolk diet on serum lipids, aortic atherosclerosis and connective tissue in male miniature pigs. (7195699)
1980
42
Coronary and aortic atherosclerosis in New Orleans. II. Comparison of lesions by age, sex, and race. (703259)
1978
43
Coronary and aortic atherosclerosis in New Orleans. I. Sampling bias due to source of autopsy specimens. (703258)
1978
44
Cigarette smoking in relation to coronary and aortic atherosclerosis. (5056830)
1972
45
On the association of cigarette smoking with coronary and aortic atherosclerosis. (5364082)
1969
46
AORTIC ATHEROSCLEROSIS IN PIGEONS AND ITS COMPLICATIONS. (14095741)
1964
47
PROBLEMS CONCERNING THE DEFINITION AND GRADING OF THE AORTIC ATHEROSCLEROSIS. (14162802)
1964
48
Aortic atherosclerosis in North India (Delhi area). (14477505)
1962
49
Interactions among dietary fat, protein, and cholesterol in atherosclerosis-susceptible pigeons. Effects on serum cholesterol and aortic atherosclerosis. (13763158)
1961
50
Effect of choline in the prevention of experimental aortic atherosclerosis. (18878120)
1948

Variations for Aortic Atherosclerosis

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Expression for genes affiliated with Aortic Atherosclerosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for genes affiliated with Aortic Atherosclerosis

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Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 51PharmGKB
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Compounds for genes affiliated with Aortic Atherosclerosis

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45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Aortic Atherosclerosis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sitosterol459.9ABCG5, ABCG8
2ceramide459.6GLA, SCARB1
3mannose459.5PLA2G7, GLA
4sucrose45 24 1111.5GLA, SCARB1
5lathosterol45 2410.5CETP, ABCG8
6probucol45 1110.5CETP, SCARB1
7lycopene45 2410.5CETP, SCARB1
8niacin45 1110.5SCARB1, CETP
9betacarotene459.4CETP, SCARB1
10alpha tocopherol459.4CETP, SCARB1
11carbohydrates459.4CETP, SCARB1
12fluvastatin45 51 29 1112.3CETP, PLA2G7
13simvastatin45 51 61 29 24 1114.3CETP, SCARB1
14triacylglycerol459.3PLA2G7, CETP
15oleic acid45 29 24 1112.3CETP, PLA2G7
16valine459.2GLA, CETP
17atp45 2910.1ABCG8, ABCG5, SCARB1
18nitric oxide45 24 1111.1SCARB1, PLA2G7, GLA
19phosphatidylserine45 29 1111.0SCARB1, CETP
20cholesterol ester458.9PLA2G7, CETP, SCARB1
21fenofibrate45 51 1110.9SCARB1, CETP, PLA2G7
22phosphatidylcholine458.9PLA2G7, CETP, SCARB1
23aspirin45 51 29 2411.9SCARB1, CETP, PLA2G7
24vitamin a45 24 1110.8CETP, SCARB1
25fatty acid458.8PLA2G7, CETP, SCARB1
26estrogen458.7SCARB1, CETP, PLA2G7
27ezetimibe45 119.6ABCG8, ABCG5, SCARB1, CETP
28sterol458.6CETP, SCARB1, ABCG5, ABCG8
29atorvastatin45 51 29 24 1112.4ABCG8, SCARB1, CETP, PLA2G7
30glucose458.3ABCG8, ABCG5, SCARB1, PLA2G7, GLA
31cholesterol45 29 24 1111.0ABCG8, ABCG5, SCARB1, CETP, PLA2G7
32phospholipid457.5GLA, PLA2G7, CETP, SCARB1, ABCG5, ABCG8
33lipid457.5ABCG8, ABCG5, SCARB1, CETP, PLA2G7, GLA

GO Terms for genes affiliated with Aortic Atherosclerosis

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16Gene Ontology
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Biological processes related to Aortic Atherosclerosis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of intestinal phytosterol absorptionGO:0109499.8ABCG5, ABCG8
2negative regulation of intestinal cholesterol absorptionGO:0457969.8ABCG5, ABCG8
3sterol transportGO:0159189.8ABCG5, ABCG8
4intestinal cholesterol absorptionGO:0302999.8ABCG5, ABCG8
5excretionGO:0075889.5ABCG5, ABCG8
6ATP catabolic processGO:0062009.5ABCG5, ABCG8
7cholesterol effluxGO:0333449.3ABCG8, ABCG5, SCARB1
8high-density lipoprotein particle remodelingGO:0343759.3CETP, SCARB1
9reverse cholesterol transportGO:0436919.3CETP, SCARB1
10response to nutrientGO:0075849.2ABCG5, ABCG8
11triglyceride homeostasisGO:0703289.2SCARB1, CETP
12low-density lipoprotein particle remodelingGO:0343749.2CETP, PLA2G7
13lipoprotein metabolic processGO:0421579.2CETP, SCARB1
14receptor-mediated endocytosisGO:0068989.0SCARB1, CETP
15phospholipid transportGO:0159148.9CETP, SCARB1, ABCG8
16cholesterol homeostasisGO:0426328.5CETP, SCARB1, ABCG5, ABCG8
17small molecule metabolic processGO:0442818.0ABCG8, ABCG5, SCARB1, CETP, GLA

Molecular functions related to Aortic Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATPase activityGO:0168879.5ABCG5, ABCG8
2cholesterol transporter activityGO:0171278.4CETP, ABCG5, ABCG8

Products for genes affiliated with Aortic Atherosclerosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aortic Atherosclerosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet