MCID: ART004
MIFTS: 38

Aortic Atherosclerosis malady

Cardiovascular diseases category

Aliases & Classifications for Aortic Atherosclerosis

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Aortic Atherosclerosis, Aliases & Descriptions:

Name: Aortic Atherosclerosis 30 9 11
 
Atherosclerosis of Aorta 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:10230
ICD9CM27 440.0
ICD1025 I70.0

Summaries for Aortic Atherosclerosis

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MalaCards based summary: Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to atherosclerosis and coronary artery disease. An important gene associated with Aortic Atherosclerosis is ABCG5 (ATP-binding cassette, sub-family G (WHITE), member 5), and among its related pathways are ABC-family proteins mediated transport and Bile secretion. The compounds sitosterol and ceramide have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and kidney, and related mouse phenotype liver/biliary system.

Related Diseases for Aortic Atherosclerosis

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Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1atherosclerosis30.7GLA, ABCG8, ABCG5, SCARB1, CETP, PLA2G7
2coronary artery disease30.5PLA2G7, CETP, SCARB1
3cholelithiasis30.1ABCG8, ABCG5, SCARB1
4artery disease10.6
5cerebritis10.4
6systemic lupus erythematosus10.2
7hepatitis10.2
8patent foramen ovale10.2
9lupus erythematosus10.2
10sitosterolemia10.2ABCG8, ABCG5
11aortitis10.2
12iga glomerulonephritis10.1GLA, PLA2G7
13cystic fibrosis10.1
14bacteremia10.1
15multiple myeloma10.1
16portal hypertension10.1
17hypertensive retinopathy10.1
18amyloidosis10.1
19atrial fibrillation10.1
20ischemia10.1
21kidney disease10.1
22myeloma10.1
23periodontal disease10.1
24periodontitis10.1
25pneumonia10.1
26uremia10.1
27aneurysm10.1
28endotheliitis10.1
29homozygous familial hypercholesterolemia10.1
30hyperalphalipoproteinemia10.0CETP, SCARB1
31abetalipoproteinemia10.0CETP, PLA2G7
32hypercholesterolemia, familial10.0PLA2G7, CETP
33congenital heart disease10.0GLA, CETP
34hypertriglyceridemia9.9PLA2G7, CETP
35nephrotic syndrome9.9PLA2G7, CETP
36familial hyperlipidemia9.9PLA2G7, CETP
37hypertension, essential9.9PLA2G7, CETP
38primary hyperoxaluria9.9GLA, CETP
39diabetes mellitus, insulin-dependent9.8CETP, PLA2G7
40vascular disease9.8PLA2G7, CETP
41proteinuria9.8CETP, PLA2G7, GLA
42metabolic syndrome x9.8GLA, CETP
43chronic kidney failure9.8GLA, PLA2G7, CETP
44stroke, ischemic9.8CETP, PLA2G7, GLA
45lipid metabolism disorder9.8PLA2G7, CETP, SCARB1
46diabetes mellitus, noninsulin-dependent9.7SCARB1, CETP, PLA2G7
47obesity9.7SCARB1, CETP, PLA2G7
48myocardial infarction9.6GLA, PLA2G7, CETP, SCARB1

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to aortic atherosclerosis

Symptoms for Aortic Atherosclerosis

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Drugs & Therapeutics for Aortic Atherosclerosis

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Drug clinical trials:

Search ClinicalTrials for Aortic Atherosclerosis

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

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Anatomical Context for Aortic Atherosclerosis

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MalaCards organs/tissues related to Aortic Atherosclerosis:

31
Heart, Smooth muscle, Kidney, Bone, Liver, Pancreas, Monocytes, Endothelial

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
id TissueAnatomical CompartmentCell Relevance
1 HeartAortic Arch ArteriesVascular Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Animal Models for Aortic Atherosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Aortic Atherosclerosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6GLA, SCARB1, ABCG5, ABCG8

Publications for Aortic Atherosclerosis

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Articles related to Aortic Atherosclerosis:

(show top 50)    (show all 285)
idTitleAuthorsYear
1
Pulse wave velocity correlates with aortic atherosclerosis assessed with transesophageal echocardiography. (25903165)
2015
2
Association between chronic kidney disease and thoracic aortic atherosclerosis detected using transesophageal echocardiography. (25299964)
2014
3
Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins. (23339166)
2013
4
Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. (24242683)
2013
5
Comprehensive evaluation of coronary artery disease and aortic atherosclerosis in acute ischemic stroke patients: usefulness based on Framingham risk score and stroke subtype. (21487225)
2011
6
In vivo knockdown of nicotinic acetylcholine receptor I+1 diminishes aortic atherosclerosis. (20810113)
2011
7
Premature aortic atherosclerosis in systemic lupus erythematosus: a controlled transesophageal echocardiographic study. (19955049)
2010
8
Amounts of aortic atherosclerosis in patients with aortic stenosis as determined by transesophageal echocardiography. (19231339)
2009
9
Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice. (19330073)
2008
10
Comparison of coronary flow velocity reserve and aortic distensibility in diabetic versus non-diabetic patients with and without aortic atherosclerosis. (18328589)
2008
11
Quantitative analysis of aortic atherosclerosis in Korean female: a necropsy study. (17596667)
2007
12
Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice. (16990555)
2006
13
The evaluation of aortic atherosclerosis and distensibility in aortic valve stenosis--the role of transesophageal echocardiography. (16256821)
2005
14
Role of calcium in the aortic atherosclerosis/stroke relation. (16360372)
2005
15
Effect of inhibitors of myeloperoxidase on the development of aortic atherosclerosis in an animal model. (15763397)
2005
16
Relationship between arterial stiffness and subclinical aortic atherosclerosis. (15262851)
2004
17
Indices of aortic distensibility and coronary flow velocity reserve in patients with different grades of aortic atherosclerosis. (15529908)
2004
18
The comparative value of the aortic atherosclerosis and the coronary flow velocity reserve evaluated by stress transesophageal echocardiography in the prediction of patients with aortic stenosis with coronary artery disease. (14609185)
2003
19
Update on imaging aortic atherosclerosis. (12760169)
2003
20
Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E-deficient mice. (12752312)
2003
21
Association of carotid artery intima-media thickness with complex aortic atherosclerosis in patients with recent stroke. (11952109)
2002
22
Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden. (11777225)
2001
23
Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly. (10657417)
2000
24
Transdermal estrogens do not appear to modify the extent of lesional areas of aortic atherosclerosis in oophorectomized rabbits on a cholesterol-rich diet. (10657566)
2000
25
Craniocervical and aortic atherosclerosis as neurologic risk factors in coronary surgery. (10750769)
2000
26
Gender differences in response to a hypercholesterolemic diet in hamsters: effects on plasma lipoprotein cholesterol concentrations and early aortic atherosclerosis. (10487490)
1999
27
Aortic sinotubular junction calcium as a marker of severe aortic atherosclerosis. (9874068)
1998
28
Surface features of human aortic atherosclerosis as seen with scanning electron microscopy. (9821792)
1998
29
Aortic atherosclerosis and stroke. (17894983)
1997
30
Quantitative assessment of abdominal aortic atherosclerosis observed in CT scans. (9258596)
1997
31
Relationship of cigarette smoking to the severity of coronary and thoracic aortic atherosclerosis. (7585737)
1995
32
Relation between aortic atherosclerosis and blood pressure. (7911961)
1994
33
J-shaped relation between change in diastolic blood pressure and progression of aortic atherosclerosis. (7906758)
1994
34
In vitro characterization of two types of LDL apheresis module and effect of repetitive LDL apheresis on plasma cholesterol levels and aortic atherosclerosis in heterozygous WHHL rabbits. (2010950)
1991
35
Suppression of aortic atherosclerosis in cholesterol-fed rabbits by purified rabbit interferon. (1690536)
1990
36
Monocyte chemoattractants in pigeon aortic atherosclerosis. (3826301)
1987
37
Operative treatment of juxtarenal aortic atherosclerosis. (3868907)
1985
38
Aortic atherosclerosis in nonlaying hens with fatty liver syndrome. (6639549)
1983
39
Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. (6870991)
1983
40
Aortic atherosclerosis in hypertensive rabbits treated with anti-hypertensive agents having different effects on arterial flow disturbances. 1. Extent of surface involvement. (7347391)
1981
41
The effects of egg yolk diet on serum lipids, aortic atherosclerosis and connective tissue in male miniature pigs. (7195699)
1980
42
Coronary and aortic atherosclerosis in New Orleans. II. Comparison of lesions by age, sex, and race. (703259)
1978
43
Coronary and aortic atherosclerosis in New Orleans. I. Sampling bias due to source of autopsy specimens. (703258)
1978
44
Cigarette smoking in relation to coronary and aortic atherosclerosis. (5056830)
1972
45
On the association of cigarette smoking with coronary and aortic atherosclerosis. (5364082)
1969
46
AORTIC ATHEROSCLEROSIS IN PIGEONS AND ITS COMPLICATIONS. (14095741)
1964
47
PROBLEMS CONCERNING THE DEFINITION AND GRADING OF THE AORTIC ATHEROSCLEROSIS. (14162802)
1964
48
Aortic atherosclerosis in North India (Delhi area). (14477505)
1962
49
Interactions among dietary fat, protein, and cholesterol in atherosclerosis-susceptible pigeons. Effects on serum cholesterol and aortic atherosclerosis. (13763158)
1961
50
Effect of choline in the prevention of experimental aortic atherosclerosis. (18878120)
1948

Variations for Aortic Atherosclerosis

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Expression for genes affiliated with Aortic Atherosclerosis

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Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for genes affiliated with Aortic Atherosclerosis

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Compounds for genes affiliated with Aortic Atherosclerosis

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Compounds related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sitosterol439.9ABCG5, ABCG8
2ceramide439.6GLA, SCARB1
3mannose439.5PLA2G7, GLA
4sucrose43 24 1211.5GLA, SCARB1
5lathosterol43 2410.5CETP, ABCG8
6probucol43 1210.5CETP, SCARB1
7lycopene43 2410.5CETP, SCARB1
8niacin43 1210.5SCARB1, CETP
9betacarotene439.4CETP, SCARB1
10alpha tocopherol439.4CETP, SCARB1
11carbohydrates439.4CETP, SCARB1
12fluvastatin43 49 28 1212.3CETP, PLA2G7
13simvastatin43 49 59 28 24 1214.3CETP, SCARB1
14triacylglycerol439.3PLA2G7, CETP
15oleic acid43 28 24 1212.3CETP, PLA2G7
16valine439.2GLA, CETP
17atp43 2810.1ABCG8, ABCG5, SCARB1
18nitric oxide43 24 1211.1SCARB1, PLA2G7, GLA
19phosphatidylserine43 28 1211.0SCARB1, CETP
20cholesterol ester438.9PLA2G7, CETP, SCARB1
21fenofibrate43 49 1210.9SCARB1, CETP, PLA2G7
22phosphatidylcholine438.9PLA2G7, CETP, SCARB1
23aspirin43 49 28 2411.9SCARB1, CETP, PLA2G7
24vitamin a43 24 1210.8CETP, SCARB1
25fatty acid438.8PLA2G7, CETP, SCARB1
26estrogen438.7SCARB1, CETP, PLA2G7
27ezetimibe43 129.6ABCG8, ABCG5, SCARB1, CETP
28sterol438.6CETP, SCARB1, ABCG5, ABCG8
29atorvastatin43 49 28 24 1212.4ABCG8, SCARB1, CETP, PLA2G7
30glucose438.3ABCG8, ABCG5, SCARB1, PLA2G7, GLA
31cholesterol43 28 24 1211.0ABCG8, ABCG5, SCARB1, CETP, PLA2G7
32phospholipid437.5GLA, PLA2G7, CETP, SCARB1, ABCG5, ABCG8
33lipid437.5ABCG8, ABCG5, SCARB1, CETP, PLA2G7, GLA

GO Terms for genes affiliated with Aortic Atherosclerosis

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Biological processes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of intestinal phytosterol absorptionGO:00109499.8ABCG5, ABCG8
2negative regulation of intestinal cholesterol absorptionGO:00457969.8ABCG5, ABCG8
3sterol transportGO:00159189.8ABCG5, ABCG8
4intestinal cholesterol absorptionGO:00302999.8ABCG5, ABCG8
5excretionGO:00075889.5ABCG5, ABCG8
6ATP catabolic processGO:00062009.5ABCG5, ABCG8
7cholesterol effluxGO:00333449.3ABCG8, ABCG5, SCARB1
8high-density lipoprotein particle remodelingGO:00343759.3CETP, SCARB1
9reverse cholesterol transportGO:00436919.3CETP, SCARB1
10response to nutrientGO:00075849.2ABCG5, ABCG8
11triglyceride homeostasisGO:00703289.2SCARB1, CETP
12low-density lipoprotein particle remodelingGO:00343749.2CETP, PLA2G7
13lipoprotein metabolic processGO:00421579.2CETP, SCARB1
14receptor-mediated endocytosisGO:00068989.0SCARB1, CETP
15phospholipid transportGO:00159148.9CETP, SCARB1, ABCG8
16cholesterol homeostasisGO:00426328.5CETP, SCARB1, ABCG5, ABCG8
17small molecule metabolic processGO:00442818.0ABCG8, ABCG5, SCARB1, CETP, GLA

Molecular functions related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATPase activityGO:00168879.5ABCG5, ABCG8
2cholesterol transporter activityGO:00171278.4CETP, ABCG5, ABCG8

Products for genes affiliated with Aortic Atherosclerosis

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  • Antibodies
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  • Antibodies
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  • Kits and Assays

Sources for Aortic Atherosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet