MCID: ART004
MIFTS: 46

Aortic Atherosclerosis malady

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Atherosclerosis

Aliases & Descriptions for Aortic Atherosclerosis:

Name: Aortic Atherosclerosis 38 12 14
Atherosclerosis of Aorta 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10230
ICD10 33 I70.0
ICD9CM 35 440.0
UMLS 69 C0155733

Summaries for Aortic Atherosclerosis

MalaCards based summary : Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to atherosclerosis and alport syndrome and thin basement membrane nephropathy. An important gene associated with Aortic Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Aspirin and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include Heart, heart and smooth muscle, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Related Diseases for Aortic Atherosclerosis

Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Related Disease Score Top Affiliating Genes
1 atherosclerosis 10.8
2 alport syndrome and thin basement membrane nephropathy 10.2 APOE LPL
3 keratoconus 4 10.2 APOE LDLR
4 hyperchlorhidrosis, isolated 10.2 APOE LPL
5 dentinogenesis imperfecta type 2 10.2 APOE LDLR
6 c1s deficiency 10.2 APOE LPL
7 albinism, oculocutaneous, type v 10.2 APOE LPA
8 myxofibrosarcoma 10.2 APOE LPL
9 hypercholesterolemia, due to ligand-defective apo b 10.1 APOE LDLR
10 lupus erythematosus panniculitis 10.1 ACE APOE
11 pontocerebellar hypoplasia, type 10 10.1 ABCA1 APOE LDLR
12 pars planitis 10.1 ACE APOE
13 neuropathy, hereditary sensory and autonomic, type ia 10.1 ABCA1 APOE LPA
14 alzheimer disease 19, late onset 10.1 APOE LDLR LPA
15 stone in bladder diverticulum 10.1 APOE LDLR LPA
16 coronary artery disease 10.1
17 artery disease 10.1
18 cetp-related hyperalphalipoproteinemia 10.1 ACE APOE
19 porencephaly 2 10.0 ACE APOE
20 joint disorders 10.0 ACE APOE LPL
21 severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome 10.0 ABCA1 APOE LDLR LPL
22 bird fancier's lung 10.0 ABCA1 APOE LPA LPL
23 gallbladder disease 4 10.0 ABCG5 ABCG8
24 optic nerve neoplasm 10.0 ACE APOE LPA
25 skin squamous cell carcinoma 10.0 APOE LDLR LPA LPL
26 von willebrand disease, platelet-type 10.0 APOE LDLR LPA LPL
27 acute apical periodontitis 10.0 APOE LDLR LPA LPL
28 immunodeficiency 18 10.0 APOE LDLR LPA LPL
29 iron metabolism disease 10.0 ABCG8 ACE APOE
30 fibrosarcoma of bone 9.9 LDLR LPA
31 malignant hyperthermia susceptibility 1 9.9 ACE LPA
32 cerebritis 9.9
33 budd-chiari syndrome 9.9 ACE APOE LPA
34 hypertriglyceridemia 9.8 ABCA1 APOE LDLR LPA LPL
35 gait apraxia 9.8 ACE APOE PON1
36 contagious pustular dermatitis 9.8 ACE APOE PON1
37 median neuropathy 9.8 ACE PON1
38 intra-abdominal lymph node mast cell malignancy 9.8 ACE APOE LPA SPP1
39 chondrocalcinosis with early-onset osteoarthritis 9.8 APOE LPA LPL PON1
40 lipomatosis 9.7 ACE APOE LDLR LPA LPL
41 patent foramen ovale 9.7
42 systemic lupus erythematosus 9.7
43 hepatitis 9.7
44 lupus erythematosus 9.7
45 endotheliitis 9.7
46 cataract 5, multiple types 9.7 ABCA1 APOE LDLR LPL PON1
47 cervix small cell carcinoma 9.7 ACE APOE LDLR PON1
48 diabetes mellitus, insulin-dependent, 20 9.6 ACE LPA LPL PON1
49 chlamydia 9.6
50 homozygous familial hypercholesterolemia 9.6

Comorbidity relations with Aortic Atherosclerosis via Phenotypic Disease Network (PDN): (show all 16)


Acute Cystitis Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Left Ventricular Outflow Tract Obstruction Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Renal Artery Atheroma Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to Aortic Atherosclerosis

Symptoms & Phenotypes for Aortic Atherosclerosis

GenomeRNAi Phenotypes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.43 ABCA1 ABCG8 APOE LDLR LPA LPL
2 Increased LDL uptake GR00340-A-1 8.8 APOE LDLR LPL

MGI Mouse Phenotypes related to Aortic Atherosclerosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 ABCA1 ABCG5 ACE APOE LDLR LPL
2 cellular MP:0005384 9.92 ABCA1 ABCG5 ABCG8 APOE LDLR LPL
3 homeostasis/metabolism MP:0005376 9.81 ABCG8 ACE APOE LDLR LPL PON1
4 digestive/alimentary MP:0005381 9.65 ABCA1 ABCG5 ABCG8 APOE LDLR
5 liver/biliary system MP:0005370 9.56 ABCA1 ABCG5 ABCG8 ACE APOE LDLR
6 muscle MP:0005369 9.1 ABCA1 ABCG5 APOE LDLR LPL SPP1

Drugs & Therapeutics for Aortic Atherosclerosis

Drugs for Aortic Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 155)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
2
Ticlopidine Approved Phase 4 55142-85-3 5472
3
Adalimumab Approved Phase 4 331731-18-1 16219006
4
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
5
Fluvastatin Approved Phase 4,Phase 3 93957-54-1 1548972
6
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
7
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
8 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
9 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
10 Antimetabolites Phase 4,Phase 3,Phase 2,Early Phase 1
11 Atorvastatin Calcium Phase 4,Phase 3,Phase 2 134523-03-8
12 Calcium, Dietary Phase 4,Phase 3,Phase 2
13 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2
14 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
15 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Early Phase 1
16 Antihypertensive Agents Phase 4,Phase 3
17 Hypoglycemic Agents Phase 4
18 Fibrinolytic Agents Phase 4,Phase 3
19 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
20 Platelet Aggregation Inhibitors Phase 4,Phase 3
21 Hormone Antagonists Phase 4,Phase 1,Phase 2
22 Hormones Phase 4,Phase 1,Phase 2
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1,Phase 2
24 Rosuvastatin Calcium Phase 4,Phase 3 147098-20-2
25 Anthralin Phase 4
26 Antirheumatic Agents Phase 4,Phase 2
27 Calcipotriene Phase 4
28 Analgesics Phase 4
29 Analgesics, Non-Narcotic Phase 4
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4
31 Antipyretics Phase 4
32 Cyclooxygenase Inhibitors Phase 4
33 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2
34 diuretics Phase 4
35 Diuretics, Potassium Sparing Phase 4
36 Mineralocorticoid Receptor Antagonists Phase 4
37 Mineralocorticoids Phase 4
38 Natriuretic Agents Phase 4
39 Ginkgo Nutraceutical Phase 4
40
Cilostazol Approved Phase 3 73963-72-1 2754
41
Dobutamine Approved Phase 3 34368-04-2 36811
42
Olmesartan Approved, Investigational Phase 3 144689-24-7, 144689-63-4 158781 130881
43
Hydroxocobalamin Approved Phase 2, Phase 3 13422-51-0 11953898 5460373 44475014
44
Atenolol Approved Phase 3 29122-68-7 2249
45
Hydrochlorothiazide Approved, Vet_approved Phase 3 58-93-5 3639
46
Lisinopril Approved, Investigational Phase 3 83915-83-7 5362119
47
Simvastatin Approved Phase 3 79902-63-9 54454
48
Pravastatin Approved Phase 3 81093-37-0 54687
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3, Early Phase 1 59-30-3 6037
50
Niacin Approved, Investigational, Nutraceutical Phase 3,Early Phase 1 59-67-6 938

Interventional clinical trials:

(show top 50) (show all 145)
id Name Status NCT ID Phase
1 Anti-inflammatory Effect of Atorvastatin in Atherosclerotic Plaques Assessed by FDG-PET Imaging Unknown status NCT00920101 Phase 4
2 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4
3 Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS Study) Unknown status NCT01208714 Phase 4
4 Rosuvastatin Affecting Aortic Valve Endothelium Completed NCT00114491 Phase 4
5 Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis Completed NCT00940862 Phase 4
6 Trial on the Effect of Adalimumab on Vascular Inflammation in Patients With Psoriasis Completed NCT01722214 Phase 4
7 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
8 Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial Completed NCT00110448 Phase 4
9 Pleiotropic Effects of Atorvastatin in High Cardiovascular Risk Patients Completed NCT01013103 Phase 4
10 A Multicenter Study of Iomeron®-400 Used With Multi-detector Computed Tomography Angiography (MDCTA) Completed NCT02596048 Phase 4
11 A Prospective, Multi-center, Single Arm Study Evaluating the Express™ Renal Premounted Stent System in the Treatment of Atherosclerotic Lesions in the Aortorenal Ostium. Completed NCT00597142 Phase 4
12 Isovue in Peripheral Digital Subtraction Angiography (DSA) Completed NCT01075217 Phase 4
13 Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial Recruiting NCT02169089 Phase 4
14 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
15 Clinical Study of the Aorta-femoral Bypass and Hybrid Intervention and the Iliac Arteries With Stenting and Plasty of the Common Femoral Artery Effectiveness in Patients With the Iliac Segment and Femoral Artery Occlusive Disease (TASC C, D) Active, not recruiting NCT02580084 Phase 4
16 Randomized Study to Evaluate the Efficacy of Fluvastatin on Inflammatory Markers in Patients With Aortic Stenosis. Suspended NCT00404287 Phase 4
17 Claudication: Exercise Versus Endoluminal Revascularization (CLEVER) Unknown status NCT00132743 Phase 3
18 Non-Invasive Cardiac Screening in High Risk Patients -The GROUND Study Unknown status NCT00189111 Phase 3
19 Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery Completed NCT01310608 Phase 3
20 A Randomized, Double Blind Study To Compare The Effects Of Olmesartan Medoxomil Versus Placebo In Patients With Established Atherosclerosis Completed NCT00382213 Phase 3
21 Conjugated Linoleic Acid and Atherosclerosis Completed NCT00706745 Phase 3
22 BVAIT: B-Vitamin Atherosclerosis Intervention Trial Completed NCT00114400 Phase 2, Phase 3
23 Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial Completed NCT01326676 Phase 3
24 High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly Completed NCT00127218 Phase 3
25 Statins in Children With Type 1 Diabetes and Hypercholesterolemia Completed NCT01236365 Phase 3
26 Magnevist® Injection Enhanced MRA at Two Dose Levels Compared to Non Contrast MRA for the Detection of Structural Abnormalities of the Infrarenal Aorta and Peripheral Arteries Completed NCT00185276 Phase 3
27 Crossover Comparison of Two Gadolinium Contrast Agents for Use With MRA of Carotid, Renal and Peripheral Arteries Completed NCT01260636 Phase 3
28 Evaluation of Cardiovascular Risk Markers in Psoriasis Patients Treated With Secukinumab Completed NCT02559622 Phase 3
29 Lowering the Risk of Operative Complications Using Atorvastatin Loading Dose Completed NCT01543555 Phase 3
30 Multicenter, Prospective, Randomized, Controlled, Double-blind Trial on the Impact of Rosuvastatin on Subclinical Markers of Atherosclerosis in Patients With Primary Necrotizing Vasculitides Recruiting NCT02117453 Phase 3
31 Aliskiren Effect on Aortic Plaque Progression Terminated NCT01417104 Phase 2, Phase 3
32 Silencing Inflammatory Activity by Injecting Nanocort in Patients at Risk for Atherosclerotic Disease Unknown status NCT01601106 Phase 1, Phase 2
33 Impact of Consumption of Oats in Lipid Profile of Children and Adolescents With Dyslipidemia Unknown status NCT01581697 Phase 1, Phase 2
34 A Study to Evaluate the Effects of 3 Months Dosing With GW856553, as Assessed FDG-PET/CT Imaging Completed NCT00633022 Phase 2
35 Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT Patients Completed NCT00995930 Phase 2
36 Colchicine in Vascular Inflammation Assessed With PET Imaging Completed NCT02162303 Phase 2
37 Efficacy Study of p38 Kinase Inhibitor to Treat Patients With Atherosclerosis Completed NCT00570752 Phase 2
38 The Transfusion Triggers in Vascular Surgery Trial Completed NCT02465125 Phase 2
39 Study of PVS-10200 for the Treatment of Restenosis in Patients With Peripheral Artery Disease (TRIUMPH) Completed NCT01099215 Phase 1, Phase 2
40 Optical Imaging Measurement of Intravascular Solution Efficacy Trial Completed NCT01743872 Phase 1, Phase 2
41 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis Recruiting NCT02667457 Phase 2
42 Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation Not yet recruiting NCT02995642 Phase 2
43 Proof of Concept Study of BMS-823778 to Assess the Effects on Atherosclerosis Withdrawn NCT01666704 Phase 2
44 Visualization of Carotid Atherosclerosis by 68Ga-MSA Completed NCT01893489 Phase 1
45 Evaluation of a New Imagingtechnologie for Thrombosis Terminated NCT02469376 Phase 1
46 Risk Factors Associated With Calcification of the Aortic Valve Unknown status NCT00375336
47 Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis Unknown status NCT01358513
48 Dietary Phytosterols and Human Aortic Valve Unknown status NCT00738933
49 The Epidemiology of Aortic Diameter in China Unknown status NCT00820378
50 Aortic Calcification - is it a Marker for Carotid Artery Stenosis? Unknown status NCT01458860

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

Anatomical Context for Aortic Atherosclerosis

MalaCards organs/tissues related to Aortic Atherosclerosis:

39
Heart, Smooth Muscle, Kidney, Endothelial, Monocytes, Liver, Pancreas
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
id Tissue Anatomical CompartmentCell Relevance
1 Heart Aortic Arch Arteries Vascular Smooth Muscle Cells Affected by disease

Publications for Aortic Atherosclerosis

Articles related to Aortic Atherosclerosis:

(show top 50) (show all 300)
id Title Authors Year
1
Aortic Atherosclerosis Determines Increased Retrograde Blood Flow as a Potential Mechanism of Retrograde Embolic Stroke. ( 28049202 )
2017
2
The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness. ( 27932239 )
2017
3
Study of the Blood Supply Fraction of the Ascending Aorta and Its Effect in Diagnosing Early Ascending Aortic Atherosclerosis. ( 26921087 )
2016
4
Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis. ( 27668706 )
2016
5
Imaging Techniques for Diagnosis of Thoracic Aortic Atherosclerosis. ( 26966580 )
2016
6
Effects of Restoration of Blood Flow on the Development of Aortic Atherosclerosis in ApoE-/- Mice With Unilateral Renal Artery Stenosis. ( 27039929 )
2016
7
Early steatohepatitis in hyperlipidemic mice with endothelial-specific gain of TRPC3 function precedes changes in aortic atherosclerosis. ( 27449657 )
2016
8
A preliminary ex vivo study of 3D ultrasonography of aortic atherosclerosis using autopsied aorta. ( 27030503 )
2016
9
An elevated IgG4 response in chronic infectious aortitis is associated with aortic atherosclerosis. ( 26336884 )
2015
10
Pulse wave velocity correlates with aortic atherosclerosis assessed with transesophageal echocardiography. ( 25903165 )
2015
11
Increasing severity of aortic atherosclerosis in coronary artery bypass grafting patients evaluated by transesophageal echocardiography. ( 25379067 )
2015
12
Establishment of Rabbit Abdominal Aortic Atherosclerosis Model by Pancreatic Elastase Infiltration Associated with High Fat Diet. ( 27122900 )
2015
13
Noninvasive imaging of aortic atherosclerosis by ultrasound biomicroscopy in a mouse model. ( 25542946 )
2015
14
3D.03: INFLUENCE OF AORTIC ATHEROSCLEROSIS ON THE PROGNOSTIC VALUE OF POSTURAL BLOOD PRESSURE CHANGES. ( 26102815 )
2015
15
Aortic Atherosclerosis: A Common Source of Cerebral Emboli, Often Overlooked! ( 25569596 )
2015
16
Blood pressure variability and aortic atherosclerosis--Cause or consequence? ( 26071655 )
2015
17
Paraoxonase (PON1) activity in patients with subclinical thoracic aortic atherosclerosis. ( 24700021 )
2014
18
Transoesophageal echocardiography of aortic atherosclerosis: the additive value of three-dimensional over two-dimensional imaging. ( 25300525 )
2014
19
No renal phenotype in human phospholipid transfer protein transgenic apolipoprotein E deficient mice despite severe aortic atherosclerosis. ( 25651711 )
2014
20
Can aortic atherosclerosis or epicardial adipose tissue volume be used as a marker for predicting coronary artery disease? ( 24954286 )
2014
21
Aortic Atherosclerosis in Systemic Lupus Erythematosus. ( 25593786 )
2014
22
MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. ( 25084135 )
2014
23
Resveratrol supplementation reduces aortic atherosclerosis and calcification and attenuates loss of aerobic capacity in a mouse model of uremia. ( 24476222 )
2014
24
Association between chronic kidney disease and thoracic aortic atherosclerosis detected using transesophageal echocardiography. ( 25299964 )
2014
25
Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins. ( 23339166 )
2013
26
Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. ( 24242683 )
2013
27
Abdominal aortic atherosclerosis at MR imaging is associated with cardiovascular events: the Dallas heart study. ( 23781118 )
2013
28
The risk association between experimental portal hypertension and an aortic atherosclerosis-like disease. ( 22730048 )
2013
29
Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. ( 23451182 )
2013
30
Uric acid and high sensitive C-reactive protein are associated with subclinical thoracic aortic atherosclerosis. ( 23159203 )
2013
31
Effect of age on aortic atherosclerosis. ( 23888172 )
2013
32
Aortic atherosclerosis and embolic events. ( 22437371 )
2012
33
Three-Dimensional Transesophageal Echocardiography of Aortic Atherosclerosis. ( 22957900 )
2012
34
The LDL-cholesterol to HDL-cholesterol ratio and the severity of coronary and aortic atherosclerosis. ( 22516791 )
2012
35
Analysis of pulse wave velocity in the thoracic aorta by flow-sensitive four-dimensional MRI: reproducibility and correlation with characteristics in patients with aortic atherosclerosis. ( 22271330 )
2012
36
Association between kidney dysfuction and the severity of coronary and aortic atherosclerosis. ( 22770127 )
2012
37
Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis. ( 22387060 )
2012
38
Relation between the incidence, location, and extent of thoracic aortic atherosclerosis detected by transesophageal echocardiography and the extent of coronary artery disease by angiography. ( 21129720 )
2011
39
Comprehensive evaluation of coronary artery disease and aortic atherosclerosis in acute ischemic stroke patients: usefulness based on Framingham risk score and stroke subtype. ( 21487225 )
2011
40
Multiple aortic atherosclerosis penetrating an ulcer. ( 21741515 )
2011
41
Comparison of frequencies of patent foramen ovale and thoracic aortic atherosclerosis in patients with cryptogenic ischemic stroke undergoing transesophageal echocardiography. ( 21889761 )
2011
42
Relationship of hypertensive retinopathy to thoracic aortic atherosclerosis in patients with severe arterial hypertension. ( 21214413 )
2011
43
In vivo knockdown of nicotinic acetylcholine receptor I+1 diminishes aortic atherosclerosis. ( 20810113 )
2011
44
PET imaging of aortic atherosclerosis: Is combined imaging of plaque anatomy and function an amaranthine quest or conceivable reality? ( 21553158 )
2011
45
Coronary computed tomography angiography without catheter angiography before bypass surgery in a patient with diffuse aortic atherosclerosis. ( 20871417 )
2011
46
Thoracic aortic atherosclerosis in patients with aortic regurgitation. ( 21696740 )
2011
47
The relationship between small pulmonary vascular alteration and aortic atherosclerosis in chronic obstructive pulmonary disease: quantitative CT analysis. ( 20947389 )
2011
48
Diagnostic accuracy of modified transoesophageal echocardiography for pre-incision assessment of aortic atherosclerosis in cardiac surgery patients. ( 20538739 )
2010
49
Carotid atherosclerosis does not predict coronary, vertebral, or aortic atherosclerosis in patients with acute stroke symptoms. ( 20595672 )
2010
50
Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis. ( 20134100 )
2010

Variations for Aortic Atherosclerosis

Expression for Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for Aortic Atherosclerosis

Pathways related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 ABCA1 ABCG5 ABCG8 APOE LDLR LPA
2
Show member pathways
12.04 ABCA1 ABCG5 ABCG8 APOE LDLR LPA
3
Show member pathways
11.99 ABCA1 APOE LDLR
4
Show member pathways
11.96 APOE LDLR LPL
5 11.4 ABCG5 ABCG8 LDLR
6 11.16 APOE SPP1
7
Show member pathways
11.14 ABCA1 ABCG5 ABCG8
8 11.08 ABCG5 ABCG8 LPL
9 11.04 ABCA1 ABCG5
10
Show member pathways
10.93 ABCA1 ABCG5 ABCG8 APOE LDLR LPL
11 10.88 ACE APOE LDLR
12 10.68 ABCA1 LDLR

GO Terms for Aortic Atherosclerosis

Cellular components related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.95 ACE APOE LPA LPL PON1 SPP1
2 external side of plasma membrane GO:0009897 9.63 ABCA1 ACE LDLR
3 extracellular space GO:0005615 9.63 ACE APOE LDLR LPL PON1 SPP1
4 receptor complex GO:0043235 9.54 ABCG5 ABCG8 LDLR
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 APOE LDLR
6 very-low-density lipoprotein particle GO:0034361 9.4 APOE LPL
7 low-density lipoprotein particle GO:0034362 9.32 APOE LDLR
8 chylomicron GO:0042627 9.26 APOE LPL
9 ATP-binding cassette (ABC) transporter complex GO:0043190 8.96 ABCG5 ABCG8
10 high-density lipoprotein particle GO:0034364 8.8 ABCA1 APOE PON1

Biological processes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.87 ABCA1 ABCG5 ABCG8 LPL
2 lipid metabolic process GO:0006629 9.8 ABCA1 APOE LDLR LPA LPL PON1
3 lipid transport GO:0006869 9.79 APOE LDLR LPA
4 steroid metabolic process GO:0008202 9.79 ABCA1 APOE LDLR
5 response to nutrient GO:0007584 9.72 ABCA1 ABCG5 ABCG8
6 cholesterol metabolic process GO:0008203 9.71 ABCA1 APOE LDLR PON1
7 triglyceride metabolic process GO:0006641 9.65 APOE LPL
8 excretion GO:0007588 9.65 ABCG5 ABCG8
9 phospholipid transport GO:0015914 9.65 ABCA1 ABCG8 LDLR
10 triglyceride homeostasis GO:0070328 9.64 APOE LPL
11 triglyceride catabolic process GO:0019433 9.64 APOE LPL
12 cholesterol transport GO:0030301 9.63 ABCA1 LDLR
13 reverse cholesterol transport GO:0043691 9.62 ABCA1 APOE
14 high-density lipoprotein particle assembly GO:0034380 9.61 ABCA1 APOE
15 low-density lipoprotein particle remodeling GO:0034374 9.6 APOE LPA
16 phospholipid efflux GO:0033700 9.59 ABCA1 APOE
17 sterol transport GO:0015918 9.58 ABCG5 ABCG8
18 lipoprotein biosynthetic process GO:0042158 9.58 ABCA1 APOE
19 chylomicron remodeling GO:0034371 9.56 APOE LPL
20 chylomicron remnant clearance GO:0034382 9.54 APOE LDLR
21 positive regulation of cholesterol efflux GO:0010875 9.54 ABCA1 APOE PON1
22 very-low-density lipoprotein particle remodeling GO:0034372 9.52 APOE LPL
23 regulation of Cdc42 protein signal transduction GO:0032489 9.51 ABCA1 APOE
24 lipoprotein catabolic process GO:0042159 9.49 APOE LDLR
25 negative regulation of intestinal cholesterol absorption GO:0045796 9.46 ABCG5 ABCG8
26 cholesterol efflux GO:0033344 9.46 ABCA1 ABCG5 ABCG8 APOE
27 negative regulation of intestinal phytosterol absorption GO:0010949 9.43 ABCG5 ABCG8
28 intestinal cholesterol absorption GO:0030299 9.43 ABCG5 ABCG8 LDLR
29 lipoprotein metabolic process GO:0042157 9.35 ABCA1 APOE LDLR LPA LPL
30 cholesterol homeostasis GO:0042632 9.1 ABCA1 ABCG5 ABCG8 APOE LDLR LPL
31 transport GO:0006810 10.1 ABCA1 ABCG5 ABCG8 APOE LDLR LPA

Molecular functions related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.54 ABCA1 ABCG5 ABCG8
2 heparin binding GO:0008201 9.5 APOE LPA LPL
3 phospholipid binding GO:0005543 9.43 ABCA1 APOE PON1
4 cholesterol binding GO:0015485 9.4 ABCA1 APOE
5 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.33 ABCA1 ABCG5 ABCG8
6 apolipoprotein binding GO:0034185 9.13 ABCA1 LPA LPL
7 cholesterol transporter activity GO:0017127 8.92 ABCA1 ABCG5 ABCG8 APOE

Sources for Aortic Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....