MCID: ART004
MIFTS: 48

Aortic Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Atherosclerosis

MalaCards integrated aliases for Aortic Atherosclerosis:

Name: Aortic Atherosclerosis 37 12 14
Atherosclerosis of Aorta 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10230
ICD10 32 I70.0
ICD9CM 34 440.0
UMLS 69 C0155733

Summaries for Aortic Atherosclerosis

MalaCards based summary : Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to cholelithiasis and kidney disease. An important gene associated with Aortic Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Angiotensin II and Olmesartan have been mentioned in the context of this disorder. Affiliated tissues include Heart, smooth muscle and heart, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Related Diseases for Aortic Atherosclerosis

Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 cholelithiasis 29.3 ABCG5 ABCG8 APOE
2 kidney disease 29.0 ACE APOE LPA
3 homozygous familial hypercholesterolemia 29.0 ABCG5 ABCG8 APOE LDLR
4 aortic valve disease 1 28.9 ACE SPP1
5 body mass index quantitative trait locus 11 28.6 APOE CETP LPA PON1
6 arteries, anomalies of 28.0 ABCA1 ACE APOE CETP LDLR LPA
7 coronary artery anomaly 28.0 ABCA1 ACE APOE CETP LDLR LPA
8 atherosclerosis susceptibility 27.3 ABCA1 ACE APOE CETP LDLR LPA
9 hypercholesterolemia, familial 27.1 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
10 hypercholesterolemia, autosomal dominant, type b 10.3 APOE LDLR
11 defective apolipoprotein b-100 10.3 APOE LDLR
12 hypobetalipoproteinemia, familial, 1 10.3 APOE LDLR
13 hypertriglyceridemia, familial 10.3 APOE CETP
14 leukodystrophy, hypomyelinating, 3 10.3 APOE LPA
15 alzheimer disease 2 10.2 APOE CETP
16 moderate and severe traumatic brain injury 10.2 ACE APOE
17 generalized atherosclerosis 10.1 ACE APOE
18 aging 10.1
19 cerebral atherosclerosis 10.1 ACE APOE
20 smith-lemli-opitz syndrome 10.1 ABCA1 APOE LDLR
21 hypoalphalipoproteinemia, primary 10.1 ABCA1 CETP LDLR
22 coronary restenosis 10.1 ACE CETP
23 hypolipoproteinemia 10.1 ABCA1 APOE LPA
24 lipoprotein glomerulopathy 10.1 APOE LDLR LPA
25 xanthomatosis 10.1 APOE LDLR LPA
26 ischemic heart disease 10.1 ACE APOE
27 hemorrhage, intracerebral 10.0 ACE APOE
28 gallbladder disease 10.0 ABCG8 APOE CETP
29 cerebritis 10.0
30 hypercholesterolemia, autosomal dominant, 3 9.9
31 abetalipoproteinemia 9.9 APOE CETP
32 hyperalphalipoproteinemia 1 9.9 ABCA1 APOE CETP LDLR
33 carotid artery disease 9.9 ACE APOE LPA
34 tangier disease 9.9 ABCA1 APOE CETP LPA
35 sitosterolemia 9.9 ABCG5 ABCG8
36 arcus corneae 9.9 APOE CETP LDLR LPA
37 hyperlipoproteinemia, type iii 9.9 APOE CETP LDLR LPA
38 lecithin:cholesterol acyltransferase deficiency 9.8 APOE CETP LDLR LPA
39 stroke, ischemic 9.8 ACE APOE LPA
40 systemic lupus erythematosus 9.8
41 hepatitis 9.8
42 patent foramen ovale 9.8
43 lupus erythematosus 9.8
44 endotheliitis 9.8
45 carotid stenosis 9.8 ACE APOE SPP1
46 aortic valve insufficiency 9.7 ACE PON1
47 alzheimer disease 9.6
48 cardiac arrhythmia 9.6
49 fibrosis of extraocular muscles, congenital, 1 9.6
50 cystic fibrosis 9.6

Comorbidity relations with Aortic Atherosclerosis via Phenotypic Disease Network (PDN): (show all 16)


Acute Cystitis Aortic Valve Disease 1
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Renal Artery Atheroma Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to Aortic Atherosclerosis

Symptoms & Phenotypes for Aortic Atherosclerosis

GenomeRNAi Phenotypes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.43 ABCA1 ABCG8 APOE CETP LDLR LPA
2 Increased LDL uptake GR00340-A-1 8.62 APOE LDLR

MGI Mouse Phenotypes related to Aortic Atherosclerosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACE APOE LDLR ABCA1 PON1 SPP1
2 cellular MP:0005384 9.87 APOE LDLR ABCA1 PON1 SPP1 ABCG5
3 homeostasis/metabolism MP:0005376 9.76 ACE APOE LDLR ABCA1 PON1 SPP1
4 digestive/alimentary MP:0005381 9.65 APOE LDLR ABCA1 ABCG5 ABCG8
5 liver/biliary system MP:0005370 9.5 ACE APOE LDLR ABCA1 SPP1 ABCG5
6 muscle MP:0005369 9.02 APOE LDLR ABCA1 SPP1 ABCG5

Drugs & Therapeutics for Aortic Atherosclerosis

Drugs for Aortic Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
2
Olmesartan Approved, Investigational Phase 3 144689-24-7, 144689-63-4 158781 130881
3 Angiotensin II Type 1 Receptor Blockers Phase 3
4 Angiotensin Receptor Antagonists Phase 3
5 Angiotensinogen Phase 3
6 Antihypertensive Agents Phase 3
7
Olmesartan medoxomil Phase 3 144689-63-4 130881
8
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
10 Antiemetics Phase 1, Phase 2
11 Anti-Inflammatory Agents Phase 1, Phase 2
12 Antineoplastic Agents, Hormonal Phase 1, Phase 2
13 Autonomic Agents Phase 1, Phase 2
14 Gastrointestinal Agents Phase 1, Phase 2
15 glucocorticoids Phase 1, Phase 2
16 Hormone Antagonists Phase 1, Phase 2
17 Hormones Phase 1, Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
19 Methylprednisolone acetate Phase 1, Phase 2
20 Methylprednisolone Hemisuccinate Phase 1, Phase 2
21 Neuroprotective Agents Phase 1, Phase 2
22 Peripheral Nervous System Agents Phase 1, Phase 2
23 Prednisolone acetate Phase 1, Phase 2
24 Prednisolone hemisuccinate Phase 1, Phase 2
25 Prednisolone phosphate Phase 1, Phase 2
26 Protective Agents Phase 1, Phase 2
27
Menthol Approved 2216-51-5 16666
28
Ethanol Approved 64-17-5 702
29
Folic Acid Approved, Nutraceutical, Vet_approved Early Phase 1 59-30-3 6037
30
Niacin Approved, Investigational, Nutraceutical Early Phase 1 59-67-6 938
31
Nicotinamide Approved, Investigational, Nutraceutical Early Phase 1 98-92-0 936
32
Glucosamine Approved, Investigational, Nutraceutical 3416-24-8 439213
33 Calcium, Dietary
34 Anti-Infective Agents
35 Anti-Infective Agents, Local
36 Central Nervous System Depressants
37 Antimetabolites Early Phase 1
38 Hypolipidemic Agents Early Phase 1
39 Lipid Regulating Agents Early Phase 1
40 Micronutrients Early Phase 1
41 Nicotinic Acids Early Phase 1
42 Trace Elements Early Phase 1
43 Vasodilator Agents Early Phase 1
44 Vitamin B Complex Early Phase 1
45 Vitamins Early Phase 1
46 Anticoagulants
47 Fibrinolytic Agents
48 Glucuronyl glucosamine glycan sulfate
49 Hypoglycemic Agents
50 Folate Nutraceutical Early Phase 1

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery Completed NCT01310608 Phase 3
2 A Randomized, Double Blind Study To Compare The Effects Of Olmesartan Medoxomil Versus Placebo In Patients With Established Atherosclerosis Completed NCT00382213 Phase 3 Olmesartan medoxomil;Placebo
3 Silencing Inflammatory Activity by Injecting Nanocort in Patients at Risk for Atherosclerotic Disease Unknown status NCT01601106 Phase 1, Phase 2 liposomal prednisolone;Placebo
4 Risk Factors Associated With Calcification of the Aortic Valve Unknown status NCT00375336
5 Predicting Aortic Stenosis Progression by Measuring Serum Calcification Propensity Unknown status NCT02241109 Early Phase 1
6 Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis Unknown status NCT01358513
7 Screening for Abdominal Aortic Aneurysm and Abdominal Aortic Atherosclerosis by Hand-Held Ultrasonography Completed NCT01679288
8 Angiogenesis and Fibrosis in Myocardial Infarction Completed NCT01813045
9 Angiogenesis and Fibrosis in Aortic Stenosis Completed NCT01837160
10 Alcohol and Atherosclerosis Pilot Study Completed NCT00786279
11 Early Aortic Valve Lipoprotein(a) Lowering Trial Recruiting NCT02109614 Early Phase 1 Extended release Niacin;Placebo Comparator
12 Interest of Pulse Wave Velocity Measurement as a Predictor of Severity of Aortic Stenosis Recruiting NCT03140735
13 Effects of Lomitapide on Carotid and Aortic Atherosclerosis Withdrawn NCT02399852 Lomitapide

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

Anatomical Context for Aortic Atherosclerosis

MalaCards organs/tissues related to Aortic Atherosclerosis:

38
Smooth Muscle, Heart, Kidney, Monocytes, Endothelial, Pancreas, Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Aortic Arch Arteries Vascular Smooth Muscle Cells Affected by disease

Publications for Aortic Atherosclerosis

Articles related to Aortic Atherosclerosis:

(show top 50) (show all 306)
# Title Authors Year
1
Aortic atherosclerosis is a key modulator of the prognostic value of postural blood pressure changes. ( 29202333 )
2018
2
Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment. ( 28406165 )
2017
3
A Protocol for Diagnosis and Management of Aortic Atherosclerosis in Cardiac Surgery Patients. ( 28852575 )
2017
4
Aortic Atherosclerosis Determines Increased Retrograde Blood Flow as a Potential Mechanism of Retrograde Embolic Stroke. ( 28049202 )
2017
5
An Obesity Paradox: Increased Body Mass Index Is Associated with Decreased Aortic Atherosclerosis. ( 28593612 )
2017
6
The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness. ( 27932239 )
2017
7
Are structural brain changes driven by aortic atherosclerosis? ( 28870632 )
2017
8
Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis. ( 28742839 )
2017
9
A preliminary ex vivo study of 3D ultrasonography of aortic atherosclerosis using autopsied aorta. ( 27030503 )
2016
10
Effects of Restoration of Blood Flow on the Development of Aortic Atherosclerosis in ApoE-/- Mice With Unilateral Renal Artery Stenosis. ( 27039929 )
2016
11
Study of the Blood Supply Fraction of the Ascending Aorta and Its Effect in Diagnosing Early Ascending Aortic Atherosclerosis. ( 26921087 )
2016
12
Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis. ( 27668706 )
2016
13
Early steatohepatitis in hyperlipidemic mice with endothelial-specific gain of TRPC3 function precedes changes in aortic atherosclerosis. ( 27449657 )
2016
14
Imaging Techniques for Diagnosis of Thoracic Aortic Atherosclerosis. ( 26966580 )
2016
15
Pulse wave velocity correlates with aortic atherosclerosis assessed with transesophageal echocardiography. ( 25903165 )
2015
16
Aortic Atherosclerosis: A Common Source of Cerebral Emboli, Often Overlooked! ( 25569596 )
2015
17
Blood pressure variability and aortic atherosclerosis--Cause or consequence? ( 26071655 )
2015
18
Noninvasive imaging of aortic atherosclerosis by ultrasound biomicroscopy in a mouse model. ( 25542946 )
2015
19
Increasing severity of aortic atherosclerosis in coronary artery bypass grafting patients evaluated by transesophageal echocardiography. ( 25379067 )
2015
20
3D.03: INFLUENCE OF AORTIC ATHEROSCLEROSIS ON THE PROGNOSTIC VALUE OF POSTURAL BLOOD PRESSURE CHANGES. ( 26102815 )
2015
21
An elevated IgG4 response in chronic infectious aortitis is associated with aortic atherosclerosis. ( 26336884 )
2015
22
Establishment of Rabbit Abdominal Aortic Atherosclerosis Model by Pancreatic Elastase Infiltration Associated with High Fat Diet. ( 27122900 )
2015
23
Aortic Atherosclerosis in Systemic Lupus Erythematosus. ( 25593786 )
2014
24
MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. ( 25084135 )
2014
25
No renal phenotype in human phospholipid transfer protein transgenic apolipoprotein E deficient mice despite severe aortic atherosclerosis. ( 25651711 )
2014
26
Resveratrol supplementation reduces aortic atherosclerosis and calcification and attenuates loss of aerobic capacity in a mouse model of uremia. ( 24476222 )
2014
27
Can aortic atherosclerosis or epicardial adipose tissue volume be used as a marker for predicting coronary artery disease? ( 24954286 )
2014
28
Association between chronic kidney disease and thoracic aortic atherosclerosis detected using transesophageal echocardiography. ( 25299964 )
2014
29
Paraoxonase (PON1) activity in patients with subclinical thoracic aortic atherosclerosis. ( 24700021 )
2014
30
Transoesophageal echocardiography of aortic atherosclerosis: the additive value of three-dimensional over two-dimensional imaging. ( 25300525 )
2014
31
Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. ( 24242683 )
2013
32
Abdominal aortic atherosclerosis at MR imaging is associated with cardiovascular events: the Dallas heart study. ( 23781118 )
2013
33
Effect of age on aortic atherosclerosis. ( 23888172 )
2013
34
Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. ( 23451182 )
2013
35
The risk association between experimental portal hypertension and an aortic atherosclerosis-like disease. ( 22730048 )
2013
36
Uric acid and high sensitive C-reactive protein are associated with subclinical thoracic aortic atherosclerosis. ( 23159203 )
2013
37
Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins. ( 23339166 )
2013
38
Analysis of pulse wave velocity in the thoracic aorta by flow-sensitive four-dimensional MRI: reproducibility and correlation with characteristics in patients with aortic atherosclerosis. ( 22271330 )
2012
39
Association between kidney dysfuction and the severity of coronary and aortic atherosclerosis. ( 22770127 )
2012
40
Aortic atherosclerosis and embolic events. ( 22437371 )
2012
41
The LDL-cholesterol to HDL-cholesterol ratio and the severity of coronary and aortic atherosclerosis. ( 22516791 )
2012
42
Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis. ( 22387060 )
2012
43
Three-Dimensional Transesophageal Echocardiography of Aortic Atherosclerosis. ( 22957900 )
2012
44
Relationship of hypertensive retinopathy to thoracic aortic atherosclerosis in patients with severe arterial hypertension. ( 21214413 )
2011
45
Comparison of frequencies of patent foramen ovale and thoracic aortic atherosclerosis in patients with cryptogenic ischemic stroke undergoing transesophageal echocardiography. ( 21889761 )
2011
46
Thoracic aortic atherosclerosis in patients with aortic regurgitation. ( 21696740 )
2011
47
Relation between the incidence, location, and extent of thoracic aortic atherosclerosis detected by transesophageal echocardiography and the extent of coronary artery disease by angiography. ( 21129720 )
2011
48
PET imaging of aortic atherosclerosis: Is combined imaging of plaque anatomy and function an amaranthine quest or conceivable reality? ( 21553158 )
2011
49
Comprehensive evaluation of coronary artery disease and aortic atherosclerosis in acute ischemic stroke patients: usefulness based on Framingham risk score and stroke subtype. ( 21487225 )
2011
50
Multiple aortic atherosclerosis penetrating an ulcer. ( 21741515 )
2011

Variations for Aortic Atherosclerosis

Expression for Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for Aortic Atherosclerosis

Pathways related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
2
Show member pathways
12.04 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
3
Show member pathways
11.97 ABCA1 APOE LDLR
4 11.35 ABCG5 ABCG8 LDLR
5
Show member pathways
11.24 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
6 11.16 APOE SPP1
7 11.14 ABCG5 ABCG8
8
Show member pathways
11.08 ABCA1 ABCG5 ABCG8
9 11.02 ABCA1 ABCG5
10 10.84 ACE APOE LDLR
11 10.81 ABCA1 CETP
12 10.65 ABCA1 LDLR

GO Terms for Aortic Atherosclerosis

Cellular components related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 ACE APOE CETP LPA PON1 SPP1
2 extracellular space GO:0005615 9.8 ACE APOE CETP LDLR PON1 SPP1
3 external side of plasma membrane GO:0009897 9.58 ABCA1 ACE LDLR
4 receptor complex GO:0043235 9.43 ABCG5 ABCG8 LDLR
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.37 APOE LDLR
6 low-density lipoprotein particle GO:0034362 9.16 APOE LDLR
7 ATP-binding cassette (ABC) transporter complex GO:0043190 8.96 ABCG5 ABCG8
8 high-density lipoprotein particle GO:0034364 8.92 ABCA1 APOE CETP PON1

Biological processes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.88 ABCA1 APOE CETP LDLR LPA PON1
2 lipid transport GO:0006869 9.83 APOE CETP LDLR LPA
3 response to nutrient GO:0007584 9.78 ABCA1 ABCG5 ABCG8
4 steroid metabolic process GO:0008202 9.78 ABCA1 APOE CETP LDLR
5 cholesterol transport GO:0030301 9.69 ABCA1 CETP LDLR
6 triglyceride metabolic process GO:0006641 9.68 APOE CETP
7 excretion GO:0007588 9.67 ABCG5 ABCG8
8 long-term memory GO:0007616 9.67 APOE LDLR
9 lipid homeostasis GO:0055088 9.67 APOE CETP
10 lipoprotein metabolic process GO:0042157 9.67 ABCA1 APOE LDLR
11 triglyceride homeostasis GO:0070328 9.66 APOE CETP
12 positive regulation of endocytosis GO:0045807 9.66 APOE LDLR
13 cellular response to low-density lipoprotein particle stimulus GO:0071404 9.65 ABCA1 LDLR
14 high-density lipoprotein particle remodeling GO:0034375 9.65 APOE CETP
15 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.65 ABCA1 CETP
16 high-density lipoprotein particle assembly GO:0034380 9.64 ABCA1 APOE
17 phospholipid efflux GO:0033700 9.64 ABCA1 APOE
18 phosphatidylcholine metabolic process GO:0046470 9.63 CETP PON1
19 regulation of cholesterol metabolic process GO:0090181 9.63 APOE LDLR
20 reverse cholesterol transport GO:0043691 9.63 ABCA1 APOE CETP
21 regulation of protein metabolic process GO:0051246 9.62 APOE LDLR
22 phospholipid homeostasis GO:0055091 9.62 ABCA1 CETP
23 chylomicron remnant clearance GO:0034382 9.61 APOE LDLR
24 positive regulation of cholesterol efflux GO:0010875 9.61 ABCA1 APOE PON1
25 regulation of Cdc42 protein signal transduction GO:0032489 9.6 ABCA1 APOE
26 very-low-density lipoprotein particle remodeling GO:0034372 9.59 APOE CETP
27 lipoprotein biosynthetic process GO:0042158 9.58 ABCA1 APOE
28 lipoprotein catabolic process GO:0042159 9.57 APOE LDLR
29 negative regulation of intestinal cholesterol absorption GO:0045796 9.56 ABCG5 ABCG8
30 phospholipid transport GO:0015914 9.56 ABCA1 ABCG8 CETP LDLR
31 negative regulation of intestinal phytosterol absorption GO:0010949 9.55 ABCG5 ABCG8
32 response to caloric restriction GO:0061771 9.54 APOE LDLR
33 low-density lipoprotein particle remodeling GO:0034374 9.54 APOE CETP LPA
34 intestinal cholesterol absorption GO:0030299 9.5 ABCG5 ABCG8 LDLR
35 cholesterol efflux GO:0033344 9.46 ABCA1 ABCG5 ABCG8 APOE
36 cholesterol metabolic process GO:0008203 9.35 ABCA1 APOE CETP LDLR PON1
37 cholesterol homeostasis GO:0042632 9.1 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
38 transport GO:0006810 10.12 ABCA1 ABCG5 ABCG8 APOE CETP LDLR

Molecular functions related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.61 ABCA1 ABCG5 ABCG8
2 phospholipid binding GO:0005543 9.43 ABCA1 APOE PON1
3 lipid transporter activity GO:0005319 9.4 APOE CETP
4 phospholipid transporter activity GO:0005548 9.37 ABCA1 CETP
5 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.33 ABCA1 ABCG5 ABCG8
6 apolipoprotein binding GO:0034185 9.32 ABCA1 LPA
7 cholesterol binding GO:0015485 9.13 ABCA1 APOE CETP
8 cholesterol transporter activity GO:0017127 9.02 ABCA1 ABCG5 ABCG8 APOE CETP

Sources for Aortic Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....