MCID: ART004
MIFTS: 45

Aortic Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Aortic Atherosclerosis

MalaCards integrated aliases for Aortic Atherosclerosis:

Name: Aortic Atherosclerosis 38 12 14
Atherosclerosis of Aorta 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10230
ICD10 33 I70.0
ICD9CM 35 440.0
UMLS 69 C0155733

Summaries for Aortic Atherosclerosis

MalaCards based summary : Aortic Atherosclerosis, also known as atherosclerosis of aorta, is related to atherosclerosis and hypercholesterolemia, due to ligand-defective apo b. An important gene associated with Aortic Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Lipoprotein metabolism. The drugs Adalimumab and Anthralin have been mentioned in the context of this disorder. Affiliated tissues include Heart, endothelial and heart, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Related Diseases for Aortic Atherosclerosis

Diseases related to Aortic Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 atherosclerosis 10.8
2 hypercholesterolemia, due to ligand-defective apo b 10.5 APOE LDLR
3 delta-1-pyrroline-5-carboxylate dehydrogenase deficiency 10.5 APOE LDLR
4 migraine with or without aura 1 10.5 APOE LPA
5 hypobetalipoproteinemia 10.3 APOE LDLR
6 autoimmune hemolytic anemia, warm type 10.3 ACE APOE
7 iron metabolism disease 10.3 ACE APOE
8 pars planitis 10.2 ACE APOE
9 meckel syndrome 10 10.2 APOE CETP
10 hyperlipidemia, familial combined 10.2 APOE CETP
11 hemochromatosis, type 5 10.2 ABCA1 APOE LDLR
12 cataract, autosomal dominant congenital 4 10.2 ACE APOE
13 conjunctival disease 10.2 ACE CETP
14 bird fancier's lung 10.2 ABCA1 APOE LPA
15 mental retardation, autosomal dominant 45 10.2 APOE LDLR LPA
16 malignant fibrous histiocytoma of bone 10.2 APOE LDLR LPA
17 retinal arteries, tortuosity of 10.1 ACE APOE
18 islet cell tumor 10.1 ACE APOE
19 pontocerebellar hypoplasia 10.1 ABCG8 APOE CETP
20 artery disease 10.1
21 coronary artery disease 10.1
22 macular degeneration, age-related, 1 10.0 ABCA1 APOE CETP
23 dermatomyositis 9.9 ABCG5 ABCG8 APOE
24 cerebritis 9.9
25 glossopharyngeal nerve disease 9.9 ACE APOE LPA
26 obesity, hyperphagia, and developmental delay 9.9 ABCA1 APOE CETP LPA
27 alzheimer disease-2 9.9 APOE CETP LDLR LPA
28 stone in bladder diverticulum 9.9 APOE CETP LDLR LPA
29 fish-eye disease 9.9 APOE CETP LDLR LPA
30 acute apical periodontitis 9.9 APOE CETP LDLR LPA
31 sitosterolemia 9.8 ABCG5 ABCG8
32 intra-abdominal lymph node mast cell malignancy 9.8 ACE APOE SPP1
33 stroke, ischemic 9.8 ACE APOE LPA
34 hepatitis 9.7
35 lupus erythematosus 9.7
36 endotheliitis 9.7
37 patent foramen ovale 9.7
38 systemic lupus erythematosus 9.7
39 infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 9.6 ABCG5 ABCG8 APOE LDLR
40 pleomorphic liposarcoma 9.6 ACE PON1
41 inhibited male orgasm 9.6 ACE APOE LPA
42 cystic fibrosis 9.6
43 pancreatitis 9.6
44 multiple myeloma 9.6
45 aortitis 9.6
46 pneumonia 9.6
47 kidney disease 9.6
48 periodontitis 9.6
49 atrial fibrillation 9.6
50 thrombosis 9.6

Comorbidity relations with Aortic Atherosclerosis via Phenotypic Disease Network (PDN): (show all 16)


Acute Cystitis Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Left Ventricular Outflow Tract Obstruction Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Renal Artery Atheroma Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Aortic Atherosclerosis:



Diseases related to Aortic Atherosclerosis

Symptoms & Phenotypes for Aortic Atherosclerosis

GenomeRNAi Phenotypes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.43 ABCA1 ABCG8 APOE CETP LDLR LPA
2 Increased LDL uptake GR00340-A-1 8.62 APOE LDLR

MGI Mouse Phenotypes related to Aortic Atherosclerosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ABCA1 ABCG5 ACE APOE LDLR PON1
2 cellular MP:0005384 9.87 ABCA1 ABCG5 ABCG8 APOE LDLR PON1
3 homeostasis/metabolism MP:0005376 9.76 LDLR PON1 SPP1 ABCA1 ABCG5 ABCG8
4 digestive/alimentary MP:0005381 9.65 ABCA1 ABCG5 ABCG8 APOE LDLR
5 liver/biliary system MP:0005370 9.5 ABCA1 ABCG5 ABCG8 ACE APOE LDLR
6 muscle MP:0005369 9.02 ABCA1 ABCG5 APOE LDLR SPP1

Drugs & Therapeutics for Aortic Atherosclerosis

Drugs for Aortic Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4 331731-18-1 16219006
2
Anthralin Approved Phase 4 1143-38-0
3
Tazarotene Approved, Investigational Phase 4 118292-40-3 5381
4
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
5
Fluvastatin Approved Phase 4,Phase 3 93957-54-1 1548972
6
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
7 sodium fluoride Approved Phase 4 7681-49-4
8 Anticholesteremic Agents Phase 4,Phase 3,Phase 2
9 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
10 Antimetabolites Phase 4,Phase 3,Phase 2,Early Phase 1
11 Atorvastatin Calcium Phase 4,Phase 3,Phase 2 134523-03-8
12 Calcium, Dietary Phase 4,Phase 3,Phase 2
13 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3,Phase 2
14 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
15 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Early Phase 1
16 Fibrinolytic Agents Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
18 Platelet Aggregation Inhibitors Phase 4,Phase 3
19 Hormone Antagonists Phase 4,Phase 1,Phase 2
20 Hormones Phase 4,Phase 1,Phase 2
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1,Phase 2
22 Rosuvastatin Calcium Phase 4,Phase 3 147098-20-2
23 Antirheumatic Agents Phase 4,Phase 2
24 Calcipotriene Phase 4
25 Analgesics Phase 4
26 Analgesics, Non-Narcotic Phase 4
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4
28 Antipyretics Phase 4
29 Cyclooxygenase Inhibitors Phase 4
30 diuretics Phase 4
31 Diuretics, Potassium Sparing Phase 4
32 Mineralocorticoid Receptor Antagonists Phase 4
33 Mineralocorticoids Phase 4
34 Natriuretic Agents Phase 4
35 Fluorides Phase 4,Phase 2
36 Listerine Phase 4
37 Ginkgo Nutraceutical Phase 4
38 alanine Nutraceutical Phase 4
39
Creatine Nutraceutical Phase 4 57-00-1 586
40
Cilostazol Approved Phase 3 73963-72-1 2754
41
Olmesartan Approved, Investigational Phase 3 144689-24-7, 144689-63-4 158781 130881
42
Hydroxocobalamin Approved Phase 2, Phase 3 13422-51-0 11953898 5460373 44475014
43
Atenolol Approved Phase 3 29122-68-7 2249
44
Hydrochlorothiazide Approved, Vet_approved Phase 3 58-93-5 3639
45
Lisinopril Approved, Investigational Phase 3 83915-83-7, 76547-98-3 5362119
46
Simvastatin Approved Phase 3 79902-63-9 54454
47
Pravastatin Approved Phase 3 81093-37-0 54687
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3, Early Phase 1 59-30-3 6037
49
Niacin Approved, Investigational, Nutraceutical Phase 3,Early Phase 1 59-67-6 938
50
Nicotinamide Approved, Nutraceutical Phase 3,Early Phase 1 98-92-0 936

Interventional clinical trials:

(show top 50) (show all 110)

id Name Status NCT ID Phase Drugs
1 Anti-inflammatory Effect of Atorvastatin in Atherosclerotic Plaques Assessed by FDG-PET Imaging Unknown status NCT00920101 Phase 4 Atorvastatin
2 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
3 Rosuvastatin Affecting Aortic Valve Endothelium Completed NCT00114491 Phase 4 Rosuvastatin
4 Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis Completed NCT00940862 Phase 4
5 Trial on the Effect of Adalimumab on Vascular Inflammation in Patients With Psoriasis Completed NCT01722214 Phase 4
6 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
7 Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) Trial Completed NCT00110448 Phase 4 Aspirin;No aspirin
8 Pleiotropic Effects of Atorvastatin in High Cardiovascular Risk Patients Completed NCT01013103 Phase 4 Atorvastatin, high vs low dose;Atorvastatin vs Placebo
9 Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial Recruiting NCT02169089 Phase 4 Spironolactone;Placebo
10 Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark Recruiting NCT00662480 Phase 4
11 Clinical Study of the Aorta-femoral Bypass and Hybrid Intervention and the Iliac Arteries With Stenting and Plasty of the Common Femoral Artery Effectiveness in Patients With the Iliac Segment and Femoral Artery Occlusive Disease (TASC C, D) Active, not recruiting NCT02580084 Phase 4
12 Rosuvastatin Effect on Atherosclerotic Plaque Metabolism - a Subclinical Atherosclerosis Imaging Study With 18F-NaF PET-CT Not yet recruiting NCT03233243 Phase 4 Rosuvastatin Oral Tablet
13 Randomized Study to Evaluate the Efficacy of Fluvastatin on Inflammatory Markers in Patients With Aortic Stenosis. Suspended NCT00404287 Phase 4 Fluvastatin
14 Claudication: Exercise Versus Endoluminal Revascularization (CLEVER) Unknown status NCT00132743 Phase 3 Cilostazol
15 Effect Study of Modified Transoesophageal Echocardiography on Cerebral Embolization After Cardiothoracic Surgery Completed NCT01310608 Phase 3
16 A Randomized, Double Blind Study To Compare The Effects Of Olmesartan Medoxomil Versus Placebo In Patients With Established Atherosclerosis Completed NCT00382213 Phase 3 Olmesartan medoxomil;Placebo
17 Conjugated Linoleic Acid and Atherosclerosis Completed NCT00706745 Phase 3
18 BVAIT: B-Vitamin Atherosclerosis Intervention Trial Completed NCT00114400 Phase 2, Phase 3 folic acid;vitamin B12;vitamin B6
19 Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial Completed NCT01326676 Phase 3 Polypill: Red Heart Pill;Usual medication
20 High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly Completed NCT00127218 Phase 3 any statin;niacin;Placebo
21 Statins in Children With Type 1 Diabetes and Hypercholesterolemia Completed NCT01236365 Phase 3 Atorvastatin;Atorvastatin Placebo
22 Magnevist® Injection Enhanced MRA at Two Dose Levels Compared to Non Contrast MRA for the Detection of Structural Abnormalities of the Infrarenal Aorta and Peripheral Arteries Completed NCT00185276 Phase 3 Gadopentetate dimeglumine (Magnevist, BAY86-4882);Gadopentetate dimeglumine (Magnevist, BAY86-4882)
23 Aliskiren Effect on Aortic Plaque Progression Terminated NCT01417104 Phase 2, Phase 3 Aliskiren;Placebo
24 Silencing Inflammatory Activity by Injecting Nanocort in Patients at Risk for Atherosclerotic Disease Unknown status NCT01601106 Phase 1, Phase 2 liposomal prednisolone;Placebo
25 Impact of Consumption of Oats in Lipid Profile of Children and Adolescents With Dyslipidemia Unknown status NCT01581697 Phase 1, Phase 2
26 A Study to Evaluate the Effects of 3 Months Dosing With GW856553, as Assessed FDG-PET/CT Imaging Completed NCT00633022 Phase 2 GW856553 7.5 mg twice a day;placebo;GW856553 7.5 mg once a day
27 Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT Patients Completed NCT00995930 Phase 2 ACZ885;Placebo
28 Colchicine in Vascular Inflammation Assessed With PET Imaging Completed NCT02162303 Phase 2 Colchicine;Placebo
29 Efficacy Study of p38 Kinase Inhibitor to Treat Patients With Atherosclerosis Completed NCT00570752 Phase 2 BMS-582949;Atorvastatin;Statin
30 The Transfusion Triggers in Vascular Surgery Trial Completed NCT02465125 Phase 2
31 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis Recruiting NCT02667457 Phase 2
32 Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation Not yet recruiting NCT02995642 Phase 2 18F-FPPRGD2
33 Proof of Concept Study of BMS-823778 to Assess the Effects on Atherosclerosis Withdrawn NCT01666704 Phase 2 BMS-823778;BMS-823778;Placebo matching with BMS-823778
34 Visualization of Carotid Atherosclerosis by 68Ga-MSA Completed NCT01893489 Phase 1
35 Evaluation of a New Imagingtechnologie for Thrombosis Terminated NCT02469376 Phase 1 [18F]-GP1
36 Risk Factors Associated With Calcification of the Aortic Valve Unknown status NCT00375336
37 Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis Unknown status NCT01358513
38 Dietary Phytosterols and Human Aortic Valve Unknown status NCT00738933
39 The Epidemiology of Aortic Diameter in China Unknown status NCT00820378
40 Aortic Calcification - is it a Marker for Carotid Artery Stenosis? Unknown status NCT01458860
41 The Relationship Between Aortic Pulse Wave and Peripheral Artery Occlusion Disease in Hemodialysis Patients Unknown status NCT01945255
42 Oxford Niaspan Study: Effects of Niaspan on Atherosclerosis and Endothelial Function Unknown status NCT00232531 Niaspan
43 Preconditioning Shields Against Vascular Events in Surgery Unknown status NCT02097186
44 Arterial Stiffness and Calcifications in Incident Renal Transplant Recipients Unknown status NCT00547040
45 Endothelial Function in Obese Adolescents Unknown status NCT01879033
46 The SMART-ORACLE Study Unknown status NCT01932671
47 Plaque Registration and Event Detection In Computed Tomography Unknown status NCT00991835
48 Relationship Between CETP Deficiency and Atherosclerosis in Patients With Hyperalphalipoproteinemia Unknown status NCT01916512
49 Screening for Abdominal Aortic Aneurysm and Abdominal Aortic Atherosclerosis by Hand-Held Ultrasonography Completed NCT01679288
50 Angiogenesis and Fibrosis in Aortic Stenosis Completed NCT01837160

Search NIH Clinical Center for Aortic Atherosclerosis

Genetic Tests for Aortic Atherosclerosis

Anatomical Context for Aortic Atherosclerosis

MalaCards organs/tissues related to Aortic Atherosclerosis:

39
Endothelial, Heart, Kidney, Liver, Bone, Smooth Muscle, Lung
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aortic Atherosclerosis:
id Tissue Anatomical CompartmentCell Relevance
1 Heart Aortic Arch Arteries Vascular Smooth Muscle Cells Affected by disease

Publications for Aortic Atherosclerosis

Articles related to Aortic Atherosclerosis:

(show top 50) (show all 305)
id Title Authors Year
1
A Protocol for Diagnosis and Management of Aortic Atherosclerosis in Cardiac Surgery Patients. ( 28852575 )
2017
2
An Obesity Paradox: Increased Body Mass Index Is Associated with Decreased Aortic Atherosclerosis. ( 28593612 )
2017
3
Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis. ( 28742839 )
2017
4
The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness. ( 27932239 )
2017
5
Are structural brain changes driven by aortic atherosclerosis? ( 28870632 )
2017
6
Aortic Atherosclerosis Determines Increased Retrograde Blood Flow as a Potential Mechanism of Retrograde Embolic Stroke. ( 28049202 )
2017
7
Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment. ( 28406165 )
2017
8
A preliminary ex vivo study of 3D ultrasonography of aortic atherosclerosis using autopsied aorta. ( 27030503 )
2016
9
Early steatohepatitis in hyperlipidemic mice with endothelial-specific gain of TRPC3 function precedes changes in aortic atherosclerosis. ( 27449657 )
2016
10
Effects of Restoration of Blood Flow on the Development of Aortic Atherosclerosis in ApoE-/- Mice With Unilateral Renal Artery Stenosis. ( 27039929 )
2016
11
Study of the Blood Supply Fraction of the Ascending Aorta and Its Effect in Diagnosing Early Ascending Aortic Atherosclerosis. ( 26921087 )
2016
12
Imaging Techniques for Diagnosis of Thoracic Aortic Atherosclerosis. ( 26966580 )
2016
13
Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis. ( 27668706 )
2016
14
3D.03: INFLUENCE OF AORTIC ATHEROSCLEROSIS ON THE PROGNOSTIC VALUE OF POSTURAL BLOOD PRESSURE CHANGES. ( 26102815 )
2015
15
Noninvasive imaging of aortic atherosclerosis by ultrasound biomicroscopy in a mouse model. ( 25542946 )
2015
16
Aortic Atherosclerosis: A Common Source of Cerebral Emboli, Often Overlooked! ( 25569596 )
2015
17
Increasing severity of aortic atherosclerosis in coronary artery bypass grafting patients evaluated by transesophageal echocardiography. ( 25379067 )
2015
18
Blood pressure variability and aortic atherosclerosis--Cause or consequence? ( 26071655 )
2015
19
Pulse wave velocity correlates with aortic atherosclerosis assessed with transesophageal echocardiography. ( 25903165 )
2015
20
An elevated IgG4 response in chronic infectious aortitis is associated with aortic atherosclerosis. ( 26336884 )
2015
21
Establishment of Rabbit Abdominal Aortic Atherosclerosis Model by Pancreatic Elastase Infiltration Associated with High Fat Diet. ( 27122900 )
2015
22
MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. ( 25084135 )
2014
23
Resveratrol supplementation reduces aortic atherosclerosis and calcification and attenuates loss of aerobic capacity in a mouse model of uremia. ( 24476222 )
2014
24
Transoesophageal echocardiography of aortic atherosclerosis: the additive value of three-dimensional over two-dimensional imaging. ( 25300525 )
2014
25
Aortic Atherosclerosis in Systemic Lupus Erythematosus. ( 25593786 )
2014
26
Association between chronic kidney disease and thoracic aortic atherosclerosis detected using transesophageal echocardiography. ( 25299964 )
2014
27
No renal phenotype in human phospholipid transfer protein transgenic apolipoprotein E deficient mice despite severe aortic atherosclerosis. ( 25651711 )
2014
28
Can aortic atherosclerosis or epicardial adipose tissue volume be used as a marker for predicting coronary artery disease? ( 24954286 )
2014
29
Paraoxonase (PON1) activity in patients with subclinical thoracic aortic atherosclerosis. ( 24700021 )
2014
30
Abdominal aortic atherosclerosis at MR imaging is associated with cardiovascular events: the Dallas heart study. ( 23781118 )
2013
31
Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. ( 23451182 )
2013
32
The risk association between experimental portal hypertension and an aortic atherosclerosis-like disease. ( 22730048 )
2013
33
Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. ( 24242683 )
2013
34
Uric acid and high sensitive C-reactive protein are associated with subclinical thoracic aortic atherosclerosis. ( 23159203 )
2013
35
Effect of age on aortic atherosclerosis. ( 23888172 )
2013
36
Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins. ( 23339166 )
2013
37
Association between kidney dysfuction and the severity of coronary and aortic atherosclerosis. ( 22770127 )
2012
38
Three-Dimensional Transesophageal Echocardiography of Aortic Atherosclerosis. ( 22957900 )
2012
39
Analysis of pulse wave velocity in the thoracic aorta by flow-sensitive four-dimensional MRI: reproducibility and correlation with characteristics in patients with aortic atherosclerosis. ( 22271330 )
2012
40
The LDL-cholesterol to HDL-cholesterol ratio and the severity of coronary and aortic atherosclerosis. ( 22516791 )
2012
41
Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis. ( 22387060 )
2012
42
Aortic atherosclerosis and embolic events. ( 22437371 )
2012
43
In vivo knockdown of nicotinic acetylcholine receptor I+1 diminishes aortic atherosclerosis. ( 20810113 )
2011
44
Comparison of frequencies of patent foramen ovale and thoracic aortic atherosclerosis in patients with cryptogenic ischemic stroke undergoing transesophageal echocardiography. ( 21889761 )
2011
45
Coronary computed tomography angiography without catheter angiography before bypass surgery in a patient with diffuse aortic atherosclerosis. ( 20871417 )
2011
46
Relation between the incidence, location, and extent of thoracic aortic atherosclerosis detected by transesophageal echocardiography and the extent of coronary artery disease by angiography. ( 21129720 )
2011
47
PET imaging of aortic atherosclerosis: Is combined imaging of plaque anatomy and function an amaranthine quest or conceivable reality? ( 21553158 )
2011
48
Thoracic aortic atherosclerosis in patients with aortic regurgitation. ( 21696740 )
2011
49
The relationship between small pulmonary vascular alteration and aortic atherosclerosis in chronic obstructive pulmonary disease: quantitative CT analysis. ( 20947389 )
2011
50
Multiple aortic atherosclerosis penetrating an ulcer. ( 21741515 )
2011

Variations for Aortic Atherosclerosis

Expression for Aortic Atherosclerosis

Search GEO for disease gene expression data for Aortic Atherosclerosis.

Pathways for Aortic Atherosclerosis

Pathways related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
2
Show member pathways
12.04 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
3 11.35 ABCG5 ABCG8 LDLR
4 11.15 APOE SPP1
5 11.12 ABCG5 ABCG8
6
Show member pathways
11.08 ABCA1 ABCG5 ABCG8
7 11 ABCA1 ABCG5
8
Show member pathways
10.93 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
9 10.88 ACE APOE LDLR
10 10.81 ABCA1 CETP
11 10.65 ABCA1 LDLR

GO Terms for Aortic Atherosclerosis

Cellular components related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.88 ACE APOE CETP LPA PON1 SPP1
2 extracellular space GO:0005615 9.8 ACE APOE CETP LDLR PON1 SPP1
3 external side of plasma membrane GO:0009897 9.61 ABCA1 ACE LDLR
4 receptor complex GO:0043235 9.43 ABCG5 ABCG8 LDLR
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.37 APOE LDLR
6 low-density lipoprotein particle GO:0034362 9.16 APOE LDLR
7 ATP-binding cassette (ABC) transporter complex GO:0043190 8.96 ABCG5 ABCG8
8 high-density lipoprotein particle GO:0034364 8.92 ABCA1 APOE CETP PON1

Biological processes related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

(show all 33)
id Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.88 ABCA1 APOE CETP LDLR LPA PON1
2 lipid transport GO:0006869 9.83 APOE CETP LDLR LPA
3 steroid metabolic process GO:0008202 9.78 ABCA1 APOE CETP LDLR
4 response to nutrient GO:0007584 9.77 ABCA1 ABCG5 ABCG8
5 cholesterol transport GO:0030301 9.69 ABCA1 CETP LDLR
6 lipoprotein metabolic process GO:0042157 9.67 ABCA1 APOE LDLR
7 triglyceride metabolic process GO:0006641 9.66 APOE CETP
8 excretion GO:0007588 9.65 ABCG5 ABCG8
9 lipid homeostasis GO:0055088 9.65 APOE CETP
10 triglyceride homeostasis GO:0070328 9.65 APOE CETP
11 high-density lipoprotein particle remodeling GO:0034375 9.64 APOE CETP
12 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.63 ABCA1 CETP
13 high-density lipoprotein particle assembly GO:0034380 9.63 ABCA1 APOE
14 reverse cholesterol transport GO:0043691 9.63 ABCA1 APOE CETP
15 phospholipid efflux GO:0033700 9.62 ABCA1 APOE
16 phosphatidylcholine metabolic process GO:0046470 9.62 CETP PON1
17 phospholipid homeostasis GO:0055091 9.61 ABCA1 CETP
18 chylomicron remnant clearance GO:0034382 9.61 APOE LDLR
19 positive regulation of cholesterol efflux GO:0010875 9.61 ABCA1 APOE PON1
20 regulation of Cdc42 protein signal transduction GO:0032489 9.59 ABCA1 APOE
21 very-low-density lipoprotein particle remodeling GO:0034372 9.58 APOE CETP
22 lipoprotein biosynthetic process GO:0042158 9.58 ABCA1 APOE
23 lipoprotein catabolic process GO:0042159 9.56 APOE LDLR
24 phospholipid transport GO:0015914 9.56 ABCA1 ABCG8 CETP LDLR
25 negative regulation of intestinal cholesterol absorption GO:0045796 9.55 ABCG5 ABCG8
26 negative regulation of intestinal phytosterol absorption GO:0010949 9.54 ABCG5 ABCG8
27 low-density lipoprotein particle remodeling GO:0034374 9.54 APOE CETP LPA
28 intestinal cholesterol absorption GO:0030299 9.5 ABCG5 ABCG8 LDLR
29 cholesterol efflux GO:0033344 9.46 ABCA1 ABCG5 ABCG8 APOE
30 cholesterol metabolic process GO:0008203 9.35 ABCA1 APOE CETP LDLR PON1
31 positive regulation of endocytosis GO:0045807 9.34 APOE
32 cholesterol homeostasis GO:0042632 9.1 ABCA1 ABCG5 ABCG8 APOE CETP LDLR
33 transport GO:0006810 10.11 ABCA1 ABCG5 ABCG8 APOE CETP LDLR

Molecular functions related to Aortic Atherosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.61 ABCA1 ABCG5 ABCG8
2 phospholipid binding GO:0005543 9.43 ABCA1 APOE PON1
3 lipid transporter activity GO:0005319 9.4 APOE CETP
4 apolipoprotein binding GO:0034185 9.37 ABCA1 LPA
5 ATPase activity, coupled to transmembrane movement of substances GO:0042626 9.33 ABCA1 ABCG5 ABCG8
6 phospholipid transporter activity GO:0005548 9.32 ABCA1 CETP
7 cholesterol binding GO:0015485 9.13 ABCA1 APOE CETP
8 cholesterol transporter activity GO:0017127 9.02 ABCA1 ABCG5 ABCG8 APOE CETP

Sources for Aortic Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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