MCID: ART031
MIFTS: 52

Aortic Coarctation malady

Rare diseases, Cardiovascular diseases, Fetal diseases categories

Aliases & Classifications for Aortic Coarctation

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Sources:
42NIH Rare Diseases, 48Orphanet, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Aortic Coarctation:

Name: Aortic Coarctation 42
Coarctation of the Aorta 42
 
Aorta Coarctation 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
aorta coarctation:
Prevalence: 1-5/10000 (Europe),6-9/10000 (Austria),1-5/10000 (Belgium),1-5/10000 (Croatia),1-5/10000 (Denmark),1-5/10000 (France),1-5/10000 (Germany),1-5/10000 (Hungary),1-5/10000 (Ireland),1-5/10000 (Italy),1-5/10000 (Malta),1-5/10000 (Netherlands),1-5/10000 (Norway),1-9/100000 (Poland),1-9/100000 (Portugal),1-5/10000 (Spain),1-5/10000 (Switzerland),1-5/10000 (United Kingdom),1-5/10000 (Ukraine); Age of onset: Infancy,Neonatal


External Ids:

Orphanet48 1457
MESH via Orphanet34 C531623, D001017
ICD10 via Orphanet26 Q25.1
UMLS via Orphanet62 C0003492
ICD1025 Q25.1

Summaries for Aortic Coarctation

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Wikipedia:64 Coarctation of the aorta, or aortic narrowing (abbreviated as CoA), is a congenital condition whereby... more...

MalaCards based summary: Aortic Coarctation, also known as coarctation of the aorta, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including coarctation of aortaand hypoplastic left heart. An important gene associated with Aortic Coarctation is ADRB1 (adrenoceptor beta 1), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Monoamine GPCRs. The compounds bucindolol and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related mouse phenotypes are adipose tissue and skeleton.

Related Diseases for Aortic Coarctation

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Diseases related to Aortic Coarctation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 226)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary hypertension30.5FBN1, EDN1
2renovascular hypertension30.4AGTR1, ACE
3congenital heart disease30.2ADRB1, ADRB2, ACE, AGTR1
4ischemia30.0AGT, ADRB2, EDN1, NOS3
5obesity29.9ADRB2, AGT, GNB3, NOS3, ADRB1
6dilated cardiomyopathy29.4EDN1, ACE, FBN1, ADRB2, CYP11B2, ADRB1
7acute myocardial infarction29.4ADRB2, ADRB1, AGTR1, AGT, ACE, EDN1
8coronary artery disease29.2ACE, AGTR1, AGT, NOS3, ADRB1, EDN1
9congestive heart failure29.2AGT, AGTR1, ACE, ADRB2, EDN1, CYP11B2
10atherosclerosis28.7AGTR1, AGT, ADRB2, ACE, GNB3, FBN1
11myocardial infarction28.7CYP11B2, AGTR1, AGT, ADRB1, EDN1, GNB3
12aneurysm10.9
13ventricular septal defect10.6
14aortic aneurysm10.6
15cerebritis10.6
16patent ductus arteriosus10.6
17left ventricular outflow tract obstruction10.6
18pulmonic stenosis10.5
19hypoaldosteronism10.5CYP11B2
20tetralogy of fallot10.5
21dextrocardia10.5
22subacute bacterial endocarditis10.5
23atrioventricular septal defect10.5
24pulmonary valve stenosis10.5
25gitelman syndrome10.4AGT
26phace syndrome10.4
27oligohydramnios10.4ACE
28aortic arch interruption10.4
29aplasia cutis congenita10.4
30congenital mitral stenosis10.4
31hepatorenal syndrome10.3EDN1
32hypertension, essential10.3AGT, GNB3
33takayasu's arteritis10.3
34thoracic aortic aneurysm10.3
35artery disease10.3
36endocarditis10.3
37alveolar capillary dysplasia10.3
38transposition of the great arteries10.3
39conn's syndrome10.3CYP11B2, AGTR1
40renal tubular dysgenesis10.3AGT, AGTR1
41pure autonomic failure10.3ACE, GNB3
42acute chest syndrome10.3NOS3
43orthostatic intolerance10.2FBN1, AGTR1
44klippel-feil syndrome10.2
45cervicitis10.2
46intracranial aneurysm10.2
47scoliosis10.2
48turner syndrome10.2
49congenitally corrected transposition of the great arteries10.2
50fibromuscular dysplasia10.2

Graphical network of the top 20 diseases related to Aortic Coarctation:



Diseases related to aortic coarctation

Symptoms for Aortic Coarctation

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HPO human phenotypes related to Aortic Coarctation:

id Description Frequency HPO Source Accession
1 coarctation of aorta HP:0001680
2 hypoplastic left heart HP:0004383

Drugs & Therapeutics for Aortic Coarctation

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Drug clinical trials:

Search ClinicalTrials for Aortic Coarctation

Search NIH Clinical Center for Aortic Coarctation

Genetic Tests for Aortic Coarctation

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Anatomical Context for Aortic Coarctation

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MalaCards organs/tissues related to Aortic Coarctation:

31
Heart, Kidney, Brain, Spinal cord, Endothelial, Pancreas, Testes

Animal Models for Aortic Coarctation or affiliated genes

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MGI Mouse Phenotypes related to Aortic Coarctation:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053757.7FBN1, AGT, NOS3, ACE, ADRB2, ADRB1
2MP:00053907.6FBN1, ADRB1, ADRB2, EDN1, NOS3
3MP:00053867.4ACE, NOS3, ADRB2, FBN1, CYP11B2, AGT
4MP:00053877.4NOS3, AGT, FBN1, ADRB2, ACE, AGTR1
5MP:00053697.3NOS3, FBN1, AGT, ADRB2, ADRB1, EDN1
6MP:00053797.1ADRB2, ACE, ADRB1, FBN1, CYP11B2, EDN1
7MP:00053677.0ACE, AGTR1, AGT, EDN1, CYP11B2, FBN1
8MP:00053786.8AGTR1, AGT, NOS3, ACE, ADRB2, ADRB1
9MP:00053856.4AGT, EDN1, CYP11B2, FBN1, ADRB1, ADRB2
10MP:00053766.3ACE, NOS3, AGT, ADRB2, ADRB1, FBN1
11MP:00107686.3AGT, NOS3, ADRB1, ACE, AGTR1, GNB3

Publications for Aortic Coarctation

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Articles related to Aortic Coarctation:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Familial aortic coarctation: a rare cause of refractory hypertension in the elderly: a case report. (25634191)
2015
2
Is Intracardiac Echocardiography Essential for Monitoring Stent Deployment across Aortic Coarctation? (25684662)
2015
3
Impact of ascending to descending aortic bypass for aortic coarctation on 3-dimensional hemodynamics. (25779545)
2015
4
Percutaneous treatment of aortic coarctation with new generation self expandable stent system and the images of 320-slice tomographic angiography. (25756570)
2015
5
Pressure fields by flow-sensitive, 4D, velocity-encoded CMR in patients with aortic coarctation. (25212797)
2014
6
Increased carotid intima-media thickness predicts cardiovascular events in aortic coarctation. (25205481)
2014
7
Transcatheter aortic valve implantation in aortic coarctation. (22215496)
2013
8
Continuous cerebral and myocardial perfusion during one-stage repair for aortic coarctation with ventricular septal defect. (23132178)
2013
9
Echo rounds: transesophageal echocardiographic imagings of endovascular stent placement for the treatment of aortic coarctation with bicuspid aortic valve. (23835451)
2013
10
Aortic coarctation and coronary artery disease: the XY factor. (22675159)
2012
11
Different transcatheter strategies for aortic coarctation associated with patent ductus arteriosus. (22929832)
2012
12
Surgical versus percutaneous treatment of aortic coarctation: new standards in an era of transcatheter repair. (23253276)
2012
13
Neurohormonal activity and vascular properties late after aortic coarctation repair. (21429604)
2012
14
Delayed onset of anterior spinal artery syndrome after repair of aortic coarctation. (22858787)
2012
15
Staged hybrid treatment of complex ascending aortic and distal aortic arch pseudoaneurysm after repair of aortic coarctation. (18948867)
2011
16
Prevalence of associated cardiovascular abnormalities in 500 patients with aortic coarctation referred for cardiovascular magnetic resonance imaging to a tertiary center. (21512788)
2011
17
Therapy refractory hypertension in adults: aortic coarctation has to be ruled out. (21475399)
2011
18
Aortic coarctation in the presence of capillary hemangioma. (21764546)
2011
19
External aortic diameter ratios: a reliable method to diagnose preductal aortic coarctation. (21609160)
2011
20
Redo sternotomy for extra-anatomical correction of aortic coarctation and mitral repair in an adult after failed endovascular treatment. (21780060)
2011
21
Surgical treatment for aortic coarctation with chronic type B dissection: report of a case. (23555479)
2011
22
Atypical chest pain and hemoptysis 27 years after aortic coarctation surgery: aortobronchial fistula, management and endovascular treatment. (21489674)
2011
23
Interrupted aortic arch and aortic coarctation: two similar entities. (20200652)
2010
24
Isolated aortic coarctation: experience in 100 consecutive patients. (20391897)
2010
25
Correction of aortic coarctation with interposition of a tube in a 12 years-old child. (21340394)
2010
26
Polysplenia/heterotaxy syndrome associated with aortic coarctation and multiple venous anomalies: multidetector computed tomography findings. (20484074)
2010
27
Technique of interventional repair in adult aortic coarctation. (20223618)
2010
28
A case of asymptomatic high-grade aortic coarctation. (21687218)
2009
29
Repair of aortic coarctation in an adult by direct aortoplasty. (19917797)
2009
30
A late presentation of Dandy-Walker malformation and aortic coarctation. (20019621)
2009
31
Sudden onset of sharp left-sided chest pain and hemoptysis in a young man with a history of childhood aortic coarctation repair. (18834811)
2009
32
Complete tracheal duplication in an adult with thoracic aortic coarctation. (19465840)
2009
33
What is the preferred therapy for patients with aortic coarctation--the standard gamble and decision analysis versus real results? (18093361)
2008
34
Surgical treatment of aortic coarctation in adults: Beneficial effect on arterial hypertension. (19039758)
2008
35
Mitral valve replacement with the beating heart technique in a patient with previous bypass graft from ascending to descending aorta due to aortic coarctation. (18304132)
2008
36
Moyamoya disease and aortic coarctation in a patient with common brachiocephalic trunk. (17347086)
2007
37
Aortic coarctation diagnosed by 64-slice computed tomography angiography. (17980292)
2007
38
Endovascular treatment of aortic coarctation in an adult with isthmic hypoplasia. (17484542)
2007
39
Reversibility of changes in hepatic vessels after correction of experimental aortic coarctation. (17152376)
2006
40
Right aortic coarctation and ventricular septal defect: an unusual cause of tracheal compression in infancy. (18377543)
2006
41
Effects of aortic coarctation on aortic antioxidant enzymes and NADPH oxidase protein expression. (15589970)
2005
42
Images in cardiology. Collateral circulation in aortic coarctation shown by 64 channel multislice computed tomography angiography. (16230439)
2005
43
Aortic coarctation endarteritis in an adult: case report with cardiovascular magnetic resonance imaging findings and review of the literature. (15712067)
2005
44
Endovascular stenting for aortic coarctation. (16181033)
2005
45
Asymptomatic aortic coarctation associated with loss of luminal continuity and intercostal artery aneurysm. (15041948)
2004
46
Percutaneous balloon dilatation of mitral valve stenosis and aortic coarctation. (12454343)
2002
47
An unusual type of combined aortic coarctation due to fibromuscular dysplasia. (10386705)
1999
48
Aortic coarctation, multiple ventricular septal defects, and anomalous coronary artery arising from the right pulmonary artery. (9451072)
1998
49
Functional aortic coarctation caused by thrombosis within a thoracic aortic aneurysm. (1572887)
1992
50
Scimitar syndrome associated with patent ductus arteriosus, aortic coarctation and irreversible pulmonary hypertension. (4236474)
1968

Variations for Aortic Coarctation

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Expression for genes affiliated with Aortic Coarctation

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Search GEO for disease gene expression data for Aortic Coarctation.

Pathways for genes affiliated with Aortic Coarctation

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Pathways related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ADRB1, ADRB2
2
Show member pathways
9.8ADRB2, ADRB1
39.6ADRB2, AGTR1
49.5ADRB2, GNB3, ADRB1
5
Show member pathways
9.5GNB3, ADRB1, ADRB2
69.5ADRB2, ADRB1, GNB3
7
Show member pathways
9.5GNB3, ADRB1, ADRB2
89.5ADRB2, ADRB1, GNB3
9
Show member pathways
Development Beta adrenergic receptors regulation of ERK59
G protein signaling G Protein alpha s signaling cascades59
G protein signaling G Protein beta gamma signaling cascades59
9.5GNB3, ADRB2, ADRB1
109.5GRK4, ADRB2, ADRB1
119.4EDN1, AGT
129.4ADRB1, AGTR1, ADRB2
13
Show member pathways
9.3AGTR1, GNB3, ADRB2
14
Show member pathways
9.2GNB3, ACE, AGT
159.0NOS3, EDN1
16
Show member pathways
8.8AGTR1, AGT, ACE, GNB3
178.7NOS3, EDN1, ADRB1
18
Show member pathways
8.7GNB3, ADRB1, NOS3, ADRB2
19
Show member pathways
8.7AGTR1, GNB3, EDN1, AGT
208.5NOS3, AGTR1, ADRB2, ADRB1
21
Show member pathways
8.5AGT, ADRB2, ADRB1, GNB3, EDN1
22
Show member pathways
Calcium Regulation in the Cardiac Cell36
8.3GNB3, ADRB1, ADRB2, GRK4, NOS3
23
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
8.3EDN1, GNB3, NOS3, AGTR1
24
Show member pathways
8.0ADRB2, AGT, EDN1, AGTR1, GNB3, ADRB1
25
Show member pathways
8.0AGTR1, AGT, ADRB2, ADRB1, GNB3, EDN1
26
Show member pathways
8.0AGT, AGTR1, NOS3, ACE, CYP11B2

Compounds for genes affiliated with Aortic Coarctation

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Compounds related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show top 50)    (show all 180)
idCompoundScoreTop Affiliating Genes
1bucindolol44 5010.6ADRB2, ADRB1, ACE
2aliskiren44 1110.4AGTR1, ACE, AGT
3saralasin449.3ACE, AGT, AGTR1
4bisoprolol44 50 1111.3ACE, ADRB2, ADRB1
5eprosartan44 28 1111.2ACE, AGTR1, AGT
6beta blocking agents509.2ADRB1, ACE, NOS3
7lacidipine449.2AGTR1, ACE, EDN1
8pd12331944 2810.2AGTR1, AGT, ACE
9trandolapril44 1110.0EDN1, ACE, AGTR1
10hydralazine44 50 1111.0AGTR1, EDN1, ACE, CYP11B2
11hydrochlorothiazide44 28 50 24 1112.9AGTR1, GNB3, ACE, CYP11B2, AGT
12chymostatin448.9AGT, EDN1, AGTR1, ACE
13benazepril44 50 1110.9AGT, ACE, ADRB2, CYP11B2, AGTR1
14valsartan44 60 28 1111.9ACE, AGTR1, AGT, EDN1
15diltiazem44 28 50 1111.8AGT, EDN1, ACE, AGTR1
16clonidine44 50 28 1111.8AGTR1, NOS3, ADRB1, GNB3
17olmesartan44 28 1110.8AGTR1, AGT, ACE
18cilazapril44 119.8ACE, EDN1, AGTR1
19captopril44 60 50 28 1112.7ACE, AGT, AGTR1, EDN1
20perindopril44 50 1110.6AGT, ACE, NOS3, AGTR1
21isoproterenol44 119.6EDN1, ADRB2, AGT, AGTR1, ADRB1
22amlodipine44 50 24 1111.6AGT, NOS3, ACE, AGTR1
23irbesartan44 28 50 1111.6AGTR1, AGT, ACE, CYP11B2, EDN1
24verapamil44 28 50 24 1112.6AGTR1, ACE, ADRB2, ADRB1, EDN1
25metoprolol44 50 28 24 1112.6ADRB1, NOS3, ADRB2, ACE, GRK4
26losartan44 50 28 1111.6AGT, ACE, EDN1, CYP11B2, AGTR1
27dopamine44 28 24 1111.6AGTR1, GRK4, AGT, GNB3, ADRB1, ADRB2
28sildenafil28 44 50 24 1112.5ACE, GNB3, EDN1, NOS3
29enalapril44 50 1110.5AGT, ACE, EDN1, AGTR1, ADRB2
30isosorbide dinitrate44 50 1110.5EDN1, NOS3, ACE
31nifedipine44 28 50 1111.5EDN1, CYP11B2, AGTR1, ACE, AGT
32l-nmma448.4NOS3, EDN1, AGT, AGTR1
33epinephrine44 24 1110.4EDN1, ADRB1, GNB3, ADRB2, AGT, AGTR1
34candesartan44 50 28 1111.4NOS3, AGT, AGTR1, ACE, CYP11B2
35nebivolol44 119.3NOS3, ACE, ADRB2, EDN1, ADRB1
36phenylephrine44 28 24 1111.3AGT, NOS3, ADRB1, EDN1, AGTR1
37potassium44 24 1110.2ADRB2, AGTR1, ACE, ADRB1, GNB3, CYP11B2
38nitroglycerin44 119.1GNB3, ACE, AGTR1, NOS3, EDN1
39glucose448.0ADRB2, AGTR1, GNB3, ADRB1, CYP11B2, AGT
40prostacyclin447.9AGTR1, AGT, NOS3, EDN1, ACE
41carvedilol44 50 28 1110.8AGTR1, ADRB1, ADRB2, ACE, NOS3, EDN1
42ang ii447.8AGT, EDN1, CYP11B2, ACE, NOS3, AGTR1
43lipid447.7FBN1, CYP11B2, GNB3, ADRB1, ADRB2, ACE
44sodium44 248.6AGT, AGTR1, EDN1, GNB3, CYP11B2, ADRB1
45acetylcholine44 50 28 24 1111.6EDN1, ADRB2, AGTR1, AGT, ACE, NOS3
46atenolol44 50 28 24 1111.6GNB3, EDN1, CYP11B2, AGTR1, AGT, ACE
47norepinephrine44 24 119.6ACE, EDN1, AGT, CYP11B2, GNB3, ADRB1
48arginine447.1ADRB1, AGT, NOS3, AGTR1, EDN1, CYP11B2
49oxygen44 248.1EDN1, AGTR1, ADRB2, CYP11B2, AGT, NOS3
50nitric oxide44 24 118.8AGTR1, EDN1, NOS3, ACE, ADRB2, ADRB1

GO Terms for genes affiliated with Aortic Coarctation

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Biological processes related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1heat generationGO:003164910.2ADRB2, ADRB1
2vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureGO:000202510.2ADRB1, ADRB2
3negative regulation of smooth muscle contractionGO:004598610.2ADRB1, ADRB2
4diet induced thermogenesisGO:000202410.2ADRB1, ADRB2
5negative regulation of multicellular organism growthGO:004001510.1ADRB1, ADRB2
6positive regulation of NAD(P)H oxidase activityGO:003386410.0AGT, AGTR1
7regulation of blood vessel size by renin-angiotensinGO:000203410.0AGT, AGTR1
8regulation of calcium ion transportGO:005192410.0ADRB1, AGT
9renin-angiotensin regulation of aldosterone productionGO:000201810.0AGTR1, AGT
10brown fat cell differentiationGO:005087310.0ADRB2, ADRB1
11regulation of renal sodium excretionGO:003581310.0AGTR1, AGT
12activation of adenylate cyclase activityGO:000719010.0ADRB2, ADRB1
13positive regulation of cholesterol esterificationGO:001087310.0AGT, AGTR1
14regulation of renal output by angiotensinGO:000201910.0AGT, ACE
15low-density lipoprotein particle remodelingGO:00343749.9AGT, AGTR1
16positive regulation of cellular protein metabolic processGO:00322709.9AGTR1, AGT
17positive regulation of macrophage derived foam cell differentiationGO:00107449.9AGT, AGTR1
18regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.9ACE, AGTR1
19angiotensin maturationGO:00020039.8ACE, AGT
20response to coldGO:00094099.8AGT, ADRB2, ADRB1
21positive regulation of reactive oxygen species metabolic processGO:020003799.8AGTR1, AGT
22artery smooth muscle contractionGO:00148249.8EDN1, AGT
23positive regulation of cardiac muscle hypertrophyGO:00106139.8EDN1, AGT
24positive regulation of renal sodium excretionGO:00358159.7EDN1, AGT
25phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.7AGT, AGTR1
26positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:00514829.7AGTR1, EDN1
27Rho protein signal transductionGO:00072669.6ADRB1, AGTR1
28regulation of sodium ion transportGO:00020289.6NOS3, ADRB2
29sensory perception of painGO:00192339.6ADRB1, EDN1
30positive regulation of endothelial cell migrationGO:00105959.6EDN1, AGT
31regulation of vasodilationGO:00423129.5AGTR1, ACE, ADRB2
32nitric oxide mediated signal transductionGO:00072639.5AGT, NOS3
33regulation of systemic arterial blood pressure by endothelinGO:00031009.4EDN1, NOS3
34calcium-mediated signalingGO:00197229.4AGTR1, EDN1
35positive regulation of inflammatory responseGO:00507299.3AGTR1, AGT
36regulation of blood pressureGO:00082179.2NOS3, ACE, GNB3
37blood vessel remodelingGO:00019749.1NOS3, ACE, AGT
38G-protein coupled receptor signaling pathwayGO:00071869.0AGT, EDN1, AGTR1, GNB3
39kidney developmentGO:00018229.0AGTR1, FBN1, AGT, ACE
40regulation of vasoconstrictionGO:00192298.9EDN1, ACE, AGT, AGTR1

Molecular functions related to Aortic Coarctation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1norepinephrine bindingGO:00513809.5ADRB2, ADRB1
2bradykinin receptor bindingGO:00317119.4AGTR1, ACE
3protein bindingGO:00055156.1FBN1, GNB3, ADRB1, ADRB2, ACE, NOS3

Sources for Aortic Coarctation

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet