MCID: ART031
MIFTS: 48

Aortic Coarctation

Categories: Rare diseases

Aliases & Classifications for Aortic Coarctation

MalaCards integrated aliases for Aortic Coarctation:

Name: Aortic Coarctation 49
Coarctation of the Aorta 49

Classifications:



Summaries for Aortic Coarctation

MalaCards based summary : Aortic Coarctation, also known as coarctation of the aorta, is related to ischemia and pulmonary edema. An important gene associated with Aortic Coarctation is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Aldosterone synthesis and secretion. The drugs Sevoflurane and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and lung, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 72 Coarctation of the aorta (CoA or CoAo), also called aortic narrowing, is a congenital condition whereby... more...

Related Diseases for Aortic Coarctation

Diseases related to Aortic Coarctation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.0 ACE EDN1 NOS3
2 pulmonary edema 29.9 ACE EDN1 NOS3
3 fibromuscular dysplasia 29.8 ACE AGT AGTR1
4 aortic valve disease 1 29.6 ACE FBN1 NOTCH1
5 acute myocardial infarction 29.5 ACE ADRB1 EDN1
6 stroke, ischemic 29.5 ACE AGTR1 FBN1 NOS3
7 renovascular hypertension 29.5 ACE AGTR1 EDN1 NOS3
8 coronary artery anomaly 29.4 ACE ADRB1 AGTR1 EDN1 NOS3
9 arteries, anomalies of 29.3 ACE AGT AGTR1 EDN1 NOS3
10 tetralogy of fallot 29.3 EDN1 FBN1 NOTCH1
11 pre-eclampsia 29.1 AGT AGTR1 EDN1 NOS3
12 aortic valve disease 2 29.0 ACE AGT FBN1 NOTCH1
13 mitral valve disease 28.9 ACE AGT AGTR1 FBN1 NOS3
14 body mass index quantitative trait locus 11 28.6 ADRB1 ADRB2 AGT GNB3 NOS3
15 congestive heart failure 28.0 ACE ADRB1 ADRB2 AGTR1 CYP11B2 EDN1
16 myocardial infarction 27.4 ACE ADRB1 ADRB2 AGT AGTR1 EDN1
17 dilated cardiomyopathy 27.1 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
18 heart disease 27.1 ACE ADRB1 ADRB2 AGTR1 EDN1 FBN1
19 cardiac septal defects with coarctation of the aorta 12.2
20 phace syndrome 11.4
21 aortic arch interruption 11.4
22 congenital heart defects, hamartomas of tongue, and polysyndactyly 11.4
23 tricuspid atresia 11.1
24 takayasu arteritis 11.0
25 aneurysm 10.6
26 vasculogenic impotence 10.4 ACE NOS3
27 prinzmetal's variant angina 10.4 EDN1 NOS3
28 hypoaldosteronism 10.4 ACE CYP11B2
29 coronary artery vasospasm 10.4 EDN1 NOS3
30 chronic mountain sickness 10.3 EDN1 NOS3
31 pediatric hypertension 10.3 ACE AGT
32 ischemic heart disease 10.3 ACE NOS3
33 acute chest syndrome 10.3 EDN1 NOS3
34 scleroderma, familial progressive 10.3 EDN1 FBN1
35 hypertensive nephropathy 10.3 ACE AGTR1
36 ventricular septal defect 10.3
37 sexual disorder 10.3 ACE EDN1 NOS3
38 cerebritis 10.2
39 aortic aneurysm 10.2
40 limb ischemia 10.2 ACE EDN1 NOS3
41 patent ductus arteriosus 1 10.2
42 sleep apnea 10.2 ACE EDN1 NOS3
43 renal artery disease 10.2 ACE AGTR1 NOS3
44 atherosclerosis susceptibility 10.2 ACE EDN1 NOS3
45 familial hyperaldosteronism 10.2 AGTR1 CYP11B2
46 idiopathic edema 10.2 ACE EDN1
47 systemic scleroderma 10.2 ACE EDN1 FBN1
48 aging 10.2
49 microvascular complications of diabetes 5 10.1 ACE AGTR1 NOS3
50 raynaud disease 10.1 AGTR1 EDN1

Graphical network of the top 20 diseases related to Aortic Coarctation:



Diseases related to Aortic Coarctation

Symptoms & Phenotypes for Aortic Coarctation

MGI Mouse Phenotypes related to Aortic Coarctation:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
2 growth/size/body region MP:0005378 10.1 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
3 adipose tissue MP:0005375 10.08 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
4 homeostasis/metabolism MP:0005376 10.07 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
5 endocrine/exocrine gland MP:0005379 10.03 ACE ADRB1 ADRB2 CYP11B2 EDN1 FBN1
6 mortality/aging MP:0010768 9.96 ACE ADRB1 AGT AGTR1 EDN1 FBN1
7 immune system MP:0005387 9.92 ACE ADRB2 AGT AGTR1 CYP11B2 FBN1
8 muscle MP:0005369 9.7 ADRB1 ADRB2 AGT EDN1 FBN1 NOS3
9 nervous system MP:0003631 9.61 AGT AGTR1 CYP11B2 ADRB2 EDN1 FBN1
10 renal/urinary system MP:0005367 9.23 NOS3 NOTCH1 ACE AGT AGTR1 CYP11B2

Drugs & Therapeutics for Aortic Coarctation

Drugs for Aortic Coarctation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4,Phase 2 28523-86-6 5206
2
Bupivacaine Approved, Investigational Phase 4,Phase 1 38396-39-3, 2180-92-9 2474
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9 Racepinephrine Approved Phase 4 329-65-7
10 Analgesics Phase 4,Phase 1
11 Central Nervous System Depressants Phase 4,Phase 2,Phase 1
12 Neurotransmitter Agents Phase 4
13 Anesthetics Phase 4,Phase 2,Phase 1
14 Anesthetics, General Phase 4,Phase 2
15 Anesthetics, Inhalation Phase 4,Phase 2
16 Anesthetics, Local Phase 4,Phase 1
17 Peripheral Nervous System Agents Phase 4,Phase 1
18 Pharmaceutical Solutions Phase 4,Phase 1
19 Platelet Aggregation Inhibitors Phase 4,Phase 2
20 Adjuvants, Anesthesia Phase 4
21 Narcotics Phase 4
22 Neuromuscular Agents Phase 4
23 Neuromuscular Blocking Agents Phase 4
24 Neuromuscular Nondepolarizing Agents Phase 4
25 Analgesics, Opioid Phase 4
26 Anesthetics, Dissociative Phase 4
27 Anesthetics, Intravenous Phase 4
28 Hypnotics and Sedatives Phase 4
29 Epinephryl borate Phase 4
30 Excitatory Amino Acid Antagonists Phase 4
31 Excitatory Amino Acids Phase 4
32 Atorvastatin Calcium Phase 4 134523-03-8
33 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
34 Anticholesteremic Agents Phase 4
35 Hypolipidemic Agents Phase 4
36 Antimetabolites Phase 4
37 Lipid Regulating Agents Phase 4
38 Calcium, Dietary Phase 4
39
Nitric Oxide Approved Phase 2 10102-43-9 145068
40
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
41
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
42
Nitroprusside Approved, Investigational Phase 2 15078-28-1 11963622
43 diuretics Phase 2
44 Sodium Potassium Chloride Symporter Inhibitors Phase 2
45 Natriuretic Agents Phase 2
46 Nitric Oxide Donors Phase 2
47 Vasodilator Agents Phase 2
48 Antihypertensive Agents Phase 2
49
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
50 Dexamethasone acetate Phase 1 1177-87-3

Interventional clinical trials:

(show all 31)

# Name Status NCT ID Phase Drugs
1 Paravertebral Nerve Blocks in Neonates Not yet recruiting NCT03408340 Phase 4 Standard of Care Anesthesia
2 Statins and Endothelial Function in Patients With Coarctation of the Aorta Terminated NCT00767572 Phase 4 atorvastatin;Sugar pill
3 Covered CP Stents for the Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta Completed NCT01278303 Phase 2
4 Furosemide and Coarctation Surgery Lung Complications Completed NCT03364842 Phase 2 Furosemide
5 Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: A Randomized Study Completed NCT00535808 Phase 2 nitroprusside;nitroglycerine;sevoflurane
6 The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta Completed NCT03074773 Phase 1 Dexamethasone;Bupivacaine
7 Radiation-Free Heart Catheterization Using MRI Recruiting NCT02739087 Phase 1
8 Proof of Concept of Model Based Cardiovascular Prediction Unknown status NCT02591940
9 T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease Unknown status NCT02350829
10 Coarctation Of the Aorta Stent Trial Completed NCT00552812
11 MRI Assessment of RV Function: Patients With TOF or Aortic Coarctation Completed NCT00277901
12 Large Diameter Advanta™ V12 Covered Stent Trial for Coarctation of the Aorta Completed NCT00978952
13 Evaluation of Image-Based Modelling on Clinical Decisions in Coarctation of the Aorta Completed NCT02700737
14 Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast Magnetic Resonance Imaging (MRI) Completed NCT00722904
15 A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt Completed NCT01340378
16 Cerebral Perfusion During Neonatal Cardiac Surgery Completed NCT01032876
17 Bupropion & Cardio Birth Defect (Slone) Completed NCT01597661 Exposure to any bupropion during the first trimester;Exposure to bupropion alone during the first trimester
18 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
19 Study of the Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery Completed NCT02325765
20 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
21 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
22 Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants Recruiting NCT02835703
23 Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment Recruiting NCT03262753
24 Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance Recruiting NCT02161471
25 National Congenital Heart Disease Audit Recruiting NCT02303535
26 Genetic Analysis of PHACE Syndrome (Hemangioma With Other Congenital Anomalies) Recruiting NCT01016756
27 Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions Active, not recruiting NCT02545790
28 Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease Enrolling by invitation NCT03147014
29 Antenatal Diagnosis of Coarctations of the Aorta. Not yet recruiting NCT03303768
30 Surgical Outcomes in Pediatric Patients With Coarctation and VSD Terminated NCT00327795
31 Aortic Arch Reconstruction Terminated NCT00277940

Search NIH Clinical Center for Aortic Coarctation

Genetic Tests for Aortic Coarctation

Anatomical Context for Aortic Coarctation

MalaCards organs/tissues related to Aortic Coarctation:

38
Heart, Endothelial, Lung, Kidney, Brain, Spinal Cord, Pancreas

Publications for Aortic Coarctation

Articles related to Aortic Coarctation:

(show top 50) (show all 665)
# Title Authors Year
1
Aortic coarctation decision making comes of age. ( 29224838 )
2018
2
Histopathological evaluation of aortic coarctation after conventional balloon angioplasty in neonates. ( 29345605 )
2018
3
Aortic Coarctation Complicated with Intracranial Aneurysm: A Case Report and Literature Review. ( 29325938 )
2018
4
Ascending aortic size in aortic coarctation depends on aortic valve morphology: Understanding the bicuspid valve phenotype. ( 29169748 )
2018
5
Assessment the effect of dexmedetomidine on incidence of paradoxical hypertension after surgical repair of aortic coarctation in pediatric patients. ( 29336388 )
2018
6
Finding value in a common medical misnomer: The importance of identifying a bovine arch in patients with aortic coarctation. ( 29248280 )
2018
7
One-stage ascending-to-abdominal aortic bypass with concomitant aortic valve procedures for aortic coarctation combined with aortic valve pathology in adult patients. ( 29235151 )
2017
8
Direct Common Carotid Artery Puncture for Endovascular Treatment of Acute Large Vessel Ischemic Stroke in a Patient with Aortic Coarctation. ( 28844548 )
2017
9
Complex aortic coarctation and a bicuspid aortic valve with severe stenosis in a 68 year-old woman. ( 29242098 )
2017
10
Mycotic aneurysm of the root of left subclavian artery associated with aortic coarctation discovered by echocardiography. ( 28681536 )
2017
11
Aortic Coarctation Repair: How I Teach It. ( 28734405 )
2017
12
Stent Therapy for Aortic Coarctation in Children <30A kg: Use of the Low Profile Valeo Stent. ( 28780709 )
2017
13
Assessment of cerebral blood flow in adult patients with aortic coarctation. ( 28566094 )
2017
14
Treating a 20 mm Hg gradient alleviates myocardial hypertrophy in experimental aortic coarctation. ( 28985849 )
2017
15
Pulmonary artery dissection complicating aortic dissection in a patient with bicuspid aortic valve and aortic coarctation. ( 28828104 )
2017
16
Aortic, Coarctation ( 28613663 )
2017
17
Beyond Pressure Gradients: The Effects of Intervention on Heart Power in Aortic Coarctation. ( 28081162 )
2017
18
Mechanical deformation in adult patients with unrepaired aortic coarctation. ( 29189934 )
2017
19
Percutaneous treatment of adult aortic coarctation with multiple intrathoracic aneurysms. ( 28647035 )
2017
20
A systematic review and meta-analysis of exercise and exercise hypertension in patients with aortic coarctation. ( 28770819 )
2017
21
Complications After Stent Placement for Aortic Coarctation: A Pictorial Essay of Computed Tomographic Angiography. ( 29065009 )
2017
22
The outcome of isolated prenatal ventricular size disproportion in the absence of aortic coarctation. ( 28598570 )
2017
23
Double-outlet left ventricle with a bicuspid pulmonary valve and aortic coarctation. ( 28881023 )
2017
24
How successful is successful? Aortic arch shape after successful aortic coarctation repair correlates with left ventricular function. ( 27776913 )
2017
25
Immediate and midterm results of balloon angioplasty for recurrent aortic coarctation in children aged<1 year. ( 29030063 )
2017
26
Changes in echocardiographic parameters and hypertensive disorders in pregnancies of women with aortic coarctation. ( 29153689 )
2017
27
3D image fusion for live guidance of stent implantation in aortic coarctation - magnetic resonance imaging and computed tomography image overlay enhances interventional technique. ( 29057001 )
2017
28
Percutaneous management of complex acquired aortic coarctation in an adult with tetralogy of Fallot and pulmonary atresia. ( 28928619 )
2017
29
Multidirectional WSS disturbances in stenotic turbulent flows: A pre- and post-intervention study in an aortic coarctation. ( 27919417 )
2017
30
Stanford type B aortic dissection in an elderly patient with silent aortic coarctation. ( 28974916 )
2017
31
Immediate and longa89term outcomes of native aortic coarctation and postsurgical aortic recoarctation treated with stent implantation: a singlea89center experience. ( 28724880 )
2017
32
Is hypertension the fate of aortic coarctation patients treated with Cheatham Platinum (CP) stent? ( 29164683 )
2017
33
Hemangioma, aortic coarctation and intracranial dolichoectasia: PHACE syndrome. ( 28211225 )
2017
34
Intravascular Treatment of Left Subclavian Artery Aneurysm Coexisting with Aortic Coarctation in an Adult Patient. ( 28401193 )
2017
35
Staged open repair for a complex adult aortic coarctation. ( 28833633 )
2017
36
Atypical infrarenal aortic coarctation. ( 29349388 )
2017
37
Intracranial and Bilateral Subclavian Arterial Aneurysms Associated with True Aortic Coarctation. ( 29259517 )
2017
38
Is the medical treatment for arterial hypertension after primary aortic coarctation repair related to age at surgery? A retrospective cohort study. ( 28595675 )
2017
39
Left Ventricular Fibrosis and Systolic Hypertension Persist in a Repaired Aortic Coarctation Model. ( 28554563 )
2017
40
Results of a multimodal approach for the management of aortic coarctation and its complications in adults. ( 28498970 )
2017
41
Virtual 3-Dimensional Computed Tomographic Surgical Planning for Severe Aortic Coarctation/Aneurysm in the Setting of Bicuspid Aortic Valve. ( 28033077 )
2017
42
Atretic aortic coarctation - transradial approach. Case series and review of the literature. ( 29250685 )
2017
43
Native aortic coarctation stenting in patients a8Y 46 years old. ( 29362572 )
2017
44
Left ventricular noncompaction associated with bicuspid aortic valve and aortic coarctation. ( 28522032 )
2017
45
Long-term outcomes after aortic coarctation repair in Maltese patients: A population-based study. ( 28580660 )
2017
46
Early Diagnosis and Repair of Double Saccular Aneurysms of the Aortic Arch Associated With Aortic Coarctation in an Infant With Loeys-Dietz Syndrome. ( 26655350 )
2016
47
Single Stage Repair for Aortic Coarctation associated with Intracardiac Defects Using Extra-Anatomic Bypass Graft in Adults. ( 27482266 )
2016
48
MRI-based computational hemodynamics in patients with aortic coarctation using the lattice Boltzmann methods: Clinical validation study. ( 27384018 )
2016
49
Aortic coarctation, aneurysm, and ventricular dysfunction in an asymptomatic infant. ( 26980403 )
2016
50
3D Geometric Analysis of the Pediatric Aorta in 3D MRA Follow-Up Images with Application to Aortic Coarctation. ( 27405687 )
2016

Variations for Aortic Coarctation

Expression for Aortic Coarctation

Search GEO for disease gene expression data for Aortic Coarctation.

Pathways for Aortic Coarctation

Pathways related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 AGT AGTR1 EDN1 GNB3 NOS3
2
Show member pathways
12.55 ADRB1 ADRB2 AGTR1 CYP11B2
3
Show member pathways
12.47 ADRB1 ADRB2 AGTR1 NOS3
4
Show member pathways
12.28 EDN1 GNB3 NOS3 NOTCH1
5 12.19 ADRB1 ADRB2 AGT GNB3 NOTCH1
6
Show member pathways
12.04 ADRB1 ADRB2 GNB3 GRK4 NOS3
7
Show member pathways
12.02 ACE AGT GNB3
8
Show member pathways
11.94 ADRB1 ADRB2 AGTR1 NOS3
9
Show member pathways
11.93 AGT AGTR1 GNB3
10 11.85 ADRB1 ADRB2 GNB3
11 11.81 AGTR1 GNB3 NOS3
12 11.76 ADRB1 ADRB2 GNB3
13 11.6 AGTR1 EDN1 NOS3
14
Show member pathways
11.26 ACE AGT AGTR1 CYP11B2 NOS3
15 11.03 ADRB1 EDN1 NOS3
16 10.97 AGTR1 FBN1
17 10.96 AGT EDN1
18 10.9 ADRB1 ADRB2
19 10.83 ACE ADRB1 ADRB2 AGT AGTR1

GO Terms for Aortic Coarctation

Biological processes related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.9 ADRB1 ADRB2 AGT EDN1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 AGT AGTR1 EDN1
3 positive regulation of protein tyrosine kinase activity GO:0061098 9.68 ACE AGT
4 brown fat cell differentiation GO:0050873 9.68 ADRB1 ADRB2
5 positive regulation of reactive oxygen species metabolic process GO:2000379 9.67 AGT AGTR1
6 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.67 AGTR1 EDN1
7 positive regulation of blood vessel diameter GO:0097755 9.67 AGT NOS3
8 kidney development GO:0001822 9.67 ACE AGT AGTR1 FBN1
9 positive regulation of cardiac muscle hypertrophy GO:0010613 9.66 AGT EDN1
10 vasodilation GO:0042311 9.66 AGT NOS3
11 regulation of sodium ion transport GO:0002028 9.65 ADRB2 NOS3
12 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.65 ADRB1 ADRB2
13 vasoconstriction GO:0042310 9.64 AGT EDN1
14 nitric oxide mediated signal transduction GO:0007263 9.64 AGT NOS3
15 positive regulation of cellular protein metabolic process GO:0032270 9.63 AGT AGTR1
16 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.63 AGT AGTR1
17 low-density lipoprotein particle remodeling GO:0034374 9.62 AGT AGTR1
18 positive regulation of renal sodium excretion GO:0035815 9.62 AGT EDN1
19 angiotensin maturation GO:0002003 9.61 ACE AGT
20 negative regulation of multicellular organism growth GO:0040015 9.61 ADRB1 ADRB2
21 blood vessel remodeling GO:0001974 9.61 ACE AGT NOS3
22 artery smooth muscle contraction GO:0014824 9.58 AGT EDN1
23 diet induced thermogenesis GO:0002024 9.58 ADRB1 ADRB2
24 positive regulation of cholesterol esterification GO:0010873 9.57 AGT AGTR1
25 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.56 EDN1 NOS3
26 positive regulation of NAD(P)H oxidase activity GO:0033864 9.55 AGT AGTR1
27 renin-angiotensin regulation of aldosterone production GO:0002018 9.54 AGT AGTR1
28 heat generation GO:0031649 9.52 ADRB1 ADRB2
29 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002025 9.51 ADRB1 ADRB2
30 regulation of blood vessel size GO:0050880 9.5 AGT EDN1 NOS3
31 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.49 AGT AGTR1
32 regulation of extracellular matrix assembly GO:1901201 9.48 AGT NOTCH1
33 regulation of renal sodium excretion GO:0035813 9.46 AGT AGTR1
34 regulation of blood vessel diameter GO:0097746 9.43 ACE ADRB2 AGTR1
35 regulation of renal output by angiotensin GO:0002019 9.4 ACE AGT
36 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 ACE AGT AGTR1
37 regulation of vasoconstriction GO:0019229 9.26 ACE AGT AGTR1 EDN1
38 regulation of blood pressure GO:0008217 9.02 ACE AGT EDN1 GNB3 NOS3
39 G-protein coupled receptor signaling pathway GO:0007186 10.07 ADRB1 ADRB2 AGT AGTR1 EDN1 GNB3

Molecular functions related to Aortic Coarctation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.67 ADRB1 ADRB2 AGTR1 GNB3
2 hormone activity GO:0005179 9.43 AGT EDN1 FBN1
3 adrenergic receptor activity GO:0004935 9.32 ADRB1 ADRB2
4 epinephrine binding GO:0051379 9.16 ADRB1 ADRB2
5 norepinephrine binding GO:0051380 8.96 ADRB1 ADRB2
6 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Aortic Coarctation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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