MCID: ART031
MIFTS: 43

Aortic Coarctation malady

Categories: Rare diseases

Aliases & Classifications for Aortic Coarctation

Aliases & Descriptions for Aortic Coarctation:

Name: Aortic Coarctation 50
Coarctation of the Aorta 50

Classifications:



Summaries for Aortic Coarctation

MalaCards based summary : Aortic Coarctation, also known as coarctation of the aorta, is related to myocardial infarction and left ventricular outflow tract obstruction. An important gene associated with Aortic Coarctation is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Development Angiotensin activation of ERK and NFAT and Cardiac Hypertrophy. The drugs Atorvastatin Calcium and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Aortic Coarctation

Diseases related to Aortic Coarctation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 28.5 ACE ADRB1 ADRB2 AGT AGTR1 EDN1
2 left ventricular outflow tract obstruction 11.4
3 phace syndrome 11.3
4 aneurysm 10.5
5 kartagener syndrome 10.2 ACE NOS3
6 proliferating trichilemmal cyst 10.2 EDN1 NOS3
7 penile cancer, childhood 10.2 ACE AGT
8 ventricular septal defect 10.2
9 hypogonadism mitral valve prolapse mental retardation 10.2 ACE CYP11B2
10 aphasia 10.2 ACE EDN1 NOS3
11 aortic aneurysm 10.2
12 oppositional defiant disorder 10.2 ACE EDN1 NOS3
13 rapidly progressive glomerulonephritis 10.2 ACE NOS3
14 pyelonephritis 10.2 ACE EDN1 NOS3
15 viral hepatitis 10.2 ACE EDN1 NOS3
16 cerebritis 10.1
17 patent ductus arteriosus 10.1
18 joint disorders 10.1 ACE AGTR1 NOS3
19 limb ischemia 10.1 ACE EDN1 NOS3
20 diabetic encephalopathy 10.1 ACE EDN1 NOS3
21 indeterminate leprosy 10.1 EDN1 NOS3
22 testicular lymphoma 10.1 ACE EDN1 FBN1
23 petrositis 10.1 ACE AGTR1 EDN1
24 citrullinemia, type ii, neonatal-onset 10.1 ACE AGTR1 NOS3
25 skull base neoplasm 10.1 EDN1 FBN1 NOS3
26 clear cell adenocarcinoma 10.1 ACE AGTR1 CYP11B2
27 fiedler's myocarditis 10.1 AGTR1 EDN1 NOS3
28 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.1 ACE AGT FBN1
29 prostate neuroendocrine neoplasm 10.0 ACE AGT AGTR1
30 preaxial polydactyly of fingers 10.0 ACE AGT AGTR1
31 cascade stomach 10.0 ACE AGT AGTR1
32 hyperuricemic nephropathy, familial juvenile 2 10.0 ACE AGT AGTR1
33 cetp-related hyperalphalipoproteinemia 10.0 ACE AGT AGTR1
34 flat umbilicus familial 10.0 ACE AGT AGTR1
35 agammaglobulinemia 6 10.0 ACE AGT AGTR1
36 hypertrichosis of eyelid 10.0 ACE ADRB1 AGTR1
37 calcinosis 10.0 ACE AGTR1 EDN1
38 systolic heart failure 10.0 ACE AGT AGTR1
39 lymphadenitis 10.0 ACE AGTR1 EDN1 NOS3
40 alpha-2-plasmin inhibitor deficiency 10.0 ACE AGTR1 EDN1 NOS3
41 familial nephrotic syndrome 10.0 ACE AGT AGTR1
42 adenocarcinoma 10.0 ADRB2 EDN1
43 pfeiffer rockelein syndrome 10.0 ADRB1 GNB3
44 adult t-cell leukemia 10.0 ACE ADRB1 EDN1
45 median neuropathy 10.0 ACE FBN1 NOTCH1
46 epithelial malignant thymoma 10.0 ADRB1 ADRB2
47 deafness, autosomal recessive 79 10.0 ACE FBN1 NOTCH1
48 iris disease 10.0 ACE AGT AGTR1 NOS3
49 eye degenerative disease 10.0 ACE AGT AGTR1 NOS3
50 coronary artery disease 9.9

Graphical network of the top 20 diseases related to Aortic Coarctation:



Diseases related to Aortic Coarctation

Symptoms & Phenotypes for Aortic Coarctation

MGI Mouse Phenotypes related to Aortic Coarctation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
2 growth/size/body region MP:0005378 10.1 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
3 adipose tissue MP:0005375 10.08 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
4 homeostasis/metabolism MP:0005376 10.07 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
5 endocrine/exocrine gland MP:0005379 10.03 CYP11B2 EDN1 FBN1 NOS3 NOTCH1 ACE
6 mortality/aging MP:0010768 9.96 ACE ADRB1 AGT AGTR1 EDN1 FBN1
7 immune system MP:0005387 9.92 ADRB2 AGT AGTR1 CYP11B2 FBN1 NOS3
8 muscle MP:0005369 9.7 ADRB1 ADRB2 AGT EDN1 FBN1 NOS3
9 nervous system MP:0003631 9.61 EDN1 FBN1 GNB3 NOS3 NOTCH1 ADRB2
10 renal/urinary system MP:0005367 9.23 ACE AGT AGTR1 CYP11B2 EDN1 FBN1

Drugs & Therapeutics for Aortic Coarctation

Drugs for Aortic Coarctation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Atorvastatin Calcium Phase 4 134523-03-8
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
3 Hypolipidemic Agents Phase 4
4 Anticholesteremic Agents Phase 4
5 Lipid Regulating Agents Phase 4
6 Antimetabolites Phase 4
7 Calcium, Dietary Phase 4
8
Nitric Oxide Approved Phase 2 10102-43-9 145068
9
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
10
Sevoflurane Approved, Vet_approved Phase 2 28523-86-6 5206
11
Nitroprusside Approved Phase 2 15078-28-1 11963622
12 Nitric Oxide Donors Phase 2
13 Anesthetics Phase 2,Phase 1
14 Anesthetics, General Phase 2
15 Anesthetics, Inhalation Phase 2
16 Vasodilator Agents Phase 2
17 Platelet Aggregation Inhibitors Phase 2
18 Antihypertensive Agents Phase 2
19 Central Nervous System Depressants Phase 2,Phase 1
20
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
21
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
22 Dexamethasone acetate Phase 1 1177-87-3
23 Analgesics Phase 1
24 glucocorticoids Phase 1
25
protease inhibitors Phase 1
26 Gastrointestinal Agents Phase 1
27 HIV Protease Inhibitors Phase 1
28 Hormone Antagonists Phase 1
29 Dexamethasone 21-phosphate Phase 1
30 Hormones Phase 1
31 Peripheral Nervous System Agents Phase 1
32 Anesthetics, Local Phase 1
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
34 Pharmaceutical Solutions Phase 1
35 Antiemetics Phase 1
36 Anti-Inflammatory Agents Phase 1
37 BB 1101 Phase 1
38 Autonomic Agents Phase 1
39 Antineoplastic Agents, Hormonal Phase 1
40
Ethanol Approved 64-17-5 702
41
Dopamine Approved 51-61-6, 62-31-7 681
42
Bupropion Approved 34841-39-9, 34911-55-2 444
43
Mechlorethamine Approved 51-75-2 4033
44
Caffeine Approved, Nutraceutical 58-08-2 2519
45 Thrombin
46 Coagulants
47 Neurotransmitter Agents
48 Neurotransmitter Uptake Inhibitors
49 Cytochrome P-450 CYP2D6 Inhibitors
50 Cytochrome P-450 Enzyme Inhibitors

Interventional clinical trials:

(show all 27)
id Name Status NCT ID Phase
1 Statins and Endothelial Function in Patients With Coarctation of the Aorta Terminated NCT00767572 Phase 4
2 Covered CP Stents for the Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta Completed NCT01278303 Phase 2
3 Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: A Randomized Study Completed NCT00535808 Phase 2
4 Radiation-Free Heart Catheterization Using MRI Recruiting NCT02739087 Phase 1
5 The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta Active, not recruiting NCT03074773 Phase 1
6 T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease Unknown status NCT02350829
7 Coarctation Of the Aorta Stent Trial Completed NCT00552812
8 MRI Assessment of RV Function: Patients With TOF or Aortic Coarctation Completed NCT00277901
9 Evaluation of Image-Based Modelling on Clinical Decisions in Coarctation of the Aorta Completed NCT02700737
10 Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast Magnetic Resonance Imaging (MRI) Completed NCT00722904
11 A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt Completed NCT01340378
12 Cerebral Perfusion During Neonatal Cardiac Surgery Completed NCT01032876
13 Bupropion & Cardio Birth Defect (Slone) Completed NCT01597661
14 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
15 Study of the Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery Completed NCT02325765
16 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
17 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
18 Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants Recruiting NCT02835703
19 Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance Recruiting NCT02161471
20 Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions Recruiting NCT02545790
21 National Congenital Heart Disease Audit Recruiting NCT02303535
22 Genetic Analysis of PHACE Syndrome (Hemangioma With Other Congenital Anomalies) Recruiting NCT01016756
23 Large Diameter Advanta™ V12 Covered Stent Trial for Coarctation of the Aorta Active, not recruiting NCT00978952
24 Proof of Concept of Model Based Cardiovascular Prediction Enrolling by invitation NCT02591940
25 Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease Enrolling by invitation NCT03147014
26 Surgical Outcomes in Pediatric Patients With Coarctation and VSD Terminated NCT00327795
27 Aortic Arch Reconstruction Terminated NCT00277940

Search NIH Clinical Center for Aortic Coarctation

Genetic Tests for Aortic Coarctation

Anatomical Context for Aortic Coarctation

MalaCards organs/tissues related to Aortic Coarctation:

39
Heart, Kidney, Endothelial, Brain, Spinal Cord, Testes, Pancreas

Publications for Aortic Coarctation

Articles related to Aortic Coarctation:

(show top 50) (show all 625)
id Title Authors Year
1
Virtual 3-Dimensional Computed Tomographic Surgical Planning for Severe Aortic Coarctation/Aneurysm in the Setting of Bicuspid Aortic Valve. ( 28033077 )
2017
2
How successful is successful? Aortic arch shape after successful aortic coarctation repair correlates with left ventricular function. ( 27776913 )
2017
3
Multidirectional WSS disturbances in stenotic turbulent flows: A pre- and post-intervention study in an aortic coarctation. ( 27919417 )
2017
4
Beyond Pressure Gradients: The Effects of Intervention on Heart Power in Aortic Coarctation. ( 28081162 )
2017
5
Reversible acute renal failure in a patient with acquired aortic coarctation. ( 27517663 )
2016
6
Previously undetected severe aortic coarctation in an adult: value of MRI. ( 27018811 )
2016
7
The agreement between oscillometric and intra-arterial technique for blood pressure monitoring in the lower extremities for infants and toddlers undergoing aortic coarctation repair. ( 27543444 )
2016
8
Aortic coarctation disclosed in a middle-aged hypertensive patient by tardus parvus waveform in renal Doppler ultrasonography. ( 27910079 )
2016
9
Infantile Aortic Coarctation in an Adult with Heart Failure. ( 27798937 )
2016
10
Upper-to-lower-limb Collateral Circulation in a Patient with Aortic Coarctation. ( 27010661 )
2016
11
Multimodality imaging of aortic coarctation: From the fetus to the adolescent. ( 27132712 )
2016
12
De Novo Migraine With Aura After Surgical Repair of Aortic Coarctation. ( 27910096 )
2016
13
Balloon Dilatation and Stenting for Aortic Coarctation: A Systematic Review and Meta-Analysis. ( 27296199 )
2016
14
Delayed Displacement of Aortic Coarctation Stent. ( 27209247 )
2016
15
Complete aortic coarctation. ( 26852306 )
2016
16
Acute anterior wall myocardial infraction in asymptomatic severe aortic Coarctation in young adult - A rare case. ( 27543476 )
2016
17
Augmentation of the Lesser Curvature With an Autologous Vascular Patch in Complex Aortic Coarctation and Interruption. ( 27021030 )
2016
18
Acute Clinical Presentation of Pseudoaneurysm and Aortopulmonary Fistula as a Very Late Complication of Aortic Coarctation Patch Repair. ( 27659858 )
2016
19
Surgical management of aortic coarctation in adolescents and adults. ( 28011739 )
2016
20
Collateral Aneurysms in Aortic Coarctation. A Contraindication for Percutaneous Intervention? ( 28034685 )
2016
21
Repair of adult aortic coarctation by resection and interposition grafting. ( 27354467 )
2016
22
Early severe coronary artery disease and aortic coarctation in a child with familial hypercholesterolaemia. ( 27903575 )
2016
23
MRI-based computational hemodynamics in patients with aortic coarctation using the lattice Boltzmann methods: Clinical validation study. ( 27384018 )
2016
24
Doppler Flow Pattern and Arterial Stiffness in Patients with Aortic Coarctation. ( 27558551 )
2016
25
Three-dimensional rotational angiography in children with an aortic coarctation. ( 27659792 )
2016
26
On-Pump Beating Heart Extraanatomical Ascending-Descending Aortic Bypass Using a Beating Heart Positioner in an Adult with Aortic Coarctation. ( 27087874 )
2016
27
Early Diagnosis and Repair of Double Saccular Aneurysms of the Aortic Arch Associated With Aortic Coarctation in an Infant With Loeys-Dietz Syndrome. ( 26655350 )
2016
28
A Rare Case of Acquired Thoracic Aortic Coarctation Treated Medically. ( 27028437 )
2016
29
Effectiveness of Balloon Angioplasty in Children With Recurrent Aortic Coarctation Depends on the Type of Aortic Arch Pathology. ( 27358058 )
2016
30
Aortic coarctation, aneurysm, and ventricular dysfunction in an asymptomatic infant. ( 26980403 )
2016
31
Image of the month: Aortic coarctation assessed by contemporary multimodality cardiac imaging. ( 27927831 )
2016
32
Beyond the aorta: partial transmission of reflected waves from aortic coarctation into supra-aortic branches modulates cerebral hemodynamics and left ventricular load. ( 27730475 )
2016
33
Giant Aneurysm in a Patient With Noncorrected and Longstanding Aortic Coarctation. ( 27000618 )
2016
34
A model of early transient pressure overload simulating repair of aortic coarctation in childhood. ( 26969131 )
2016
35
Aortic coarctation associated with thrombosis mimicking interrupted arch. ( 27252229 )
2016
36
COAST-ing Toward Covered Stents forA Aortic Coarctation: Not All Plain Sailing! ( 26896891 )
2016
37
Aortic Coarctation 28 Days after an Arterial Switch Operation in a Neonate. ( 27547151 )
2016
38
A 2-Step Extra-Anatomic Bypass Rescue Procedure for Bridging Aortic Coarctation in a Patient With Multiorgan Failure. ( 26927010 )
2016
39
Balloon angioplasty of severe aortic coarctation in a newborn, using axillary artery access: The first experience in Turkey. ( 27774972 )
2016
40
Repair of aortic coarctation in infancy: A 10-year clinical experience. ( 27084872 )
2016
41
Realistic aortic phantom to study hemodynamics using MRI and cardiac catheterization in normal and aortic coarctation conditions. ( 26969867 )
2016
42
Growing potential of small aortic valve with aortic coarctation or interrupted aortic arch after bilateral pulmonary artery banding. ( 27371606 )
2016
43
Double Invasive Blood Pressure Monitoring for Cesarean Delivery in a Pregnant Woman With Aortic Coarctation. ( 27310898 )
2016
44
Early and Long-Term Results of Stent Implantation for Aortic Coarctation in Pediatric Patients Compared to Adolescents: A Single Center Experience. ( 26925287 )
2016
45
Thoracic Stent Graft Implantation for Aortic Coarctation with Patent Ductus Arteriosus via Retroperitoneal Iliac Approach in the Presence of Small Sized Femoral Artery. ( 27242935 )
2016
46
3D Geometric Analysis of the Pediatric Aorta in 3D MRA Follow-Up Images with Application to Aortic Coarctation. ( 27405687 )
2016
47
Mycotic Pseudoaneurysm Complicating Stent Placement forA Native Aortic Coarctation inA aA Child. ( 27106463 )
2016
48
Single Stage Repair for Aortic Coarctation associated with Intracardiac Defects Using Extra-Anatomic Bypass Graft in Adults. ( 27482266 )
2016
49
Endovascular Treatment of a Complicated Acute Type B Aortic Dissection in a Patient With Aortic Coarctation. ( 27720668 )
2016
50
MRI as a tool for non-invasive vascular profiling: a pilot study in patients with aortic coarctation. ( 27227178 )
2016

Variations for Aortic Coarctation

Expression for Aortic Coarctation

Search GEO for disease gene expression data for Aortic Coarctation.

Pathways for Aortic Coarctation

Pathways related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 AGT AGTR1 EDN1 GNB3 NOS3
2
Show member pathways
12.5 ADRB1 ADRB2 AGT EDN1 GNB3
3 12.27 ADRB1 ADRB2 GNB3 NOTCH1
4
Show member pathways
12.04 ADRB1 ADRB2 GNB3 GRK4 NOS3
5
Show member pathways
12 ACE AGT GNB3
6
Show member pathways
11.92 AGT AGTR1 GNB3
7
Show member pathways
11.89 ADRB1 ADRB2 AGTR1 NOS3
8 11.85 ADRB1 ADRB2 GNB3
9 11.81 AGTR1 GNB3 NOS3
10 11.75 ADRB1 ADRB2 GNB3
11 11.6 AGTR1 EDN1 NOS3
12
Show member pathways
11.26 ACE AGT AGTR1 CYP11B2 NOS3
13 10.96 AGTR1 FBN1
14 10.96 ADRB1 EDN1 NOS3
15 10.95 AGT EDN1
16 10.89 ADRB1 ADRB2
17 10.83 ACE ADRB1 ADRB2 AGT AGTR1

GO Terms for Aortic Coarctation

Biological processes related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 40)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.91 ADRB1 ADRB2 AGT EDN1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 AGT AGTR1 EDN1
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.68 AGT AGTR1
4 brown fat cell differentiation GO:0050873 9.68 ADRB1 ADRB2
5 positive regulation of protein tyrosine kinase activity GO:0061098 9.68 ACE AGT
6 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.67 AGTR1 EDN1
7 positive regulation of vasodilation GO:0045909 9.67 AGT NOS3
8 vasodilation GO:0042311 9.67 AGT NOS3
9 kidney development GO:0001822 9.67 ACE AGT AGTR1 FBN1
10 regulation of sodium ion transport GO:0002028 9.66 ADRB2 NOS3
11 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.65 ADRB1 ADRB2
12 nitric oxide mediated signal transduction GO:0007263 9.65 AGT NOS3
13 vasoconstriction GO:0042310 9.65 AGT EDN1
14 positive regulation of cardiac muscle hypertrophy GO:0010613 9.64 AGT EDN1
15 positive regulation of cellular protein metabolic process GO:0032270 9.64 AGT AGTR1
16 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.63 AGT AGTR1
17 low-density lipoprotein particle remodeling GO:0034374 9.63 AGT AGTR1
18 blood vessel remodeling GO:0001974 9.63 ACE AGT NOS3
19 positive regulation of renal sodium excretion GO:0035815 9.62 AGT EDN1
20 negative regulation of multicellular organism growth GO:0040015 9.62 ADRB1 ADRB2
21 angiotensin maturation GO:0002003 9.61 ACE AGT
22 regulation of blood vessel diameter GO:0097746 9.6 ACE AGTR1
23 artery smooth muscle contraction GO:0014824 9.59 AGT EDN1
24 diet induced thermogenesis GO:0002024 9.58 ADRB1 ADRB2
25 positive regulation of cholesterol esterification GO:0010873 9.58 AGT AGTR1
26 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.56 EDN1 NOS3
27 positive regulation of NAD(P)H oxidase activity GO:0033864 9.55 AGT AGTR1
28 renin-angiotensin regulation of aldosterone production GO:0002018 9.54 AGT AGTR1
29 regulation of renal sodium excretion GO:0035813 9.52 AGT AGTR1
30 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure GO:0002025 9.51 ADRB1 ADRB2
31 regulation of blood vessel size GO:0050880 9.5 AGT EDN1 NOS3
32 heat generation GO:0031649 9.49 ADRB1 ADRB2
33 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.48 AGT AGTR1
34 regulation of renal output by angiotensin GO:0002019 9.43 ACE AGT
35 regulation of vasodilation GO:0042312 9.43 ACE ADRB2 AGTR1
36 regulation of extracellular matrix assembly GO:1901201 9.4 AGT NOTCH1
37 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 ACE AGT AGTR1
38 regulation of vasoconstriction GO:0019229 9.26 ACE AGT AGTR1 EDN1
39 regulation of blood pressure GO:0008217 9.02 ACE AGT EDN1 GNB3 NOS3
40 G-protein coupled receptor signaling pathway GO:0007186 10.04 ADRB1 ADRB2 AGT AGTR1 EDN1 GNB3

Molecular functions related to Aortic Coarctation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.67 ADRB1 ADRB2 AGTR1 GNB3
2 hormone activity GO:0005179 9.43 AGT EDN1 FBN1
3 adrenergic receptor activity GO:0004935 9.32 ADRB1 ADRB2
4 epinephrine binding GO:0051379 9.16 ADRB1 ADRB2
5 norepinephrine binding GO:0051380 8.96 ADRB1 ADRB2
6 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Aortic Coarctation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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