MCID: ART031
MIFTS: 43

Aortic Coarctation

Categories: Rare diseases

Aliases & Classifications for Aortic Coarctation

MalaCards integrated aliases for Aortic Coarctation:

Name: Aortic Coarctation 50
Coarctation of the Aorta 50

Classifications:



Summaries for Aortic Coarctation

MalaCards based summary : Aortic Coarctation, also known as coarctation of the aorta, is related to renovascular hypertension and myocardial infarction. An important gene associated with Aortic Coarctation is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are NFAT and Cardiac Hypertrophy and Development Angiotensin activation of ERK. The drugs Anticholesteremic Agents and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Aortic Coarctation

Diseases related to Aortic Coarctation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
id Related Disease Score Top Affiliating Genes
1 renovascular hypertension 30.1 EDN1 NOS3
2 myocardial infarction 26.6 ACE ADRB1 ADRB2 AGT AGTR1 EDN1
3 aortopulmonary window 23.2 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
4 left ventricular outflow tract obstruction 11.4
5 phace syndrome 11.3
6 tricuspid atresia 11.0
7 epithelial predominant pulmonary blastoma 10.6 ACE NOS3
8 progressive black carbon hyperpigmentation of infancy 10.6 EDN1 NOS3
9 hypodontia of incisors and premolars 10.5 ACE CYP11B2
10 indeterminate leprosy 10.5 EDN1 NOS3
11 aneurysm 10.5
12 islet cell tumor 10.5 ACE NOS3
13 lethal congenital contractural syndrome 2 10.5 EDN1 NOS3
14 pelizaeus-merzbacher-like disease 10.5 ACE AGT
15 munchausen by proxy 10.4 ACE EDN1 NOS3
16 renal fibrosis 10.4 ACE EDN1 NOS3
17 pyelonephritis 10.4 ACE EDN1 NOS3
18 diabetic encephalopathy 10.4 ACE EDN1 NOS3
19 clitoris cancer 10.4 ACE AGTR1 NOS3
20 periampullary adenoma 10.3 ACE EDN1 NOS3
21 idiopathic juxtafoveal retinal telangiectasia 10.3 ACE EDN1
22 hereditary cerebral amyloid angiopathy 10.3 AGTR1 CYP11B2
23 suppurative otitis media 10.3 ACE FBN1
24 traumatic glaucoma 10.3 EDN1 NOS3
25 temporomandibular ankylosis 10.3 ACE EDN1 FBN1
26 peroxisomal biogenesis disorders 10.3 ADRB1 GNB3
27 skull base neoplasm 10.3 EDN1 FBN1 NOS3
28 citrullinemia, adult-onset type ii 10.3 ACE AGTR1 NOS3
29 broad ligament malignant neoplasm 10.2 ACE AGTR1 EDN1
30 familial isolated pituitary adenoma 10.2 AGT AGTR1
31 antiphospholipid syndrome 10.2 ADRB2 EDN1
32 ventricular septal defect 10.2
33 female breast upper-outer quadrant cancer 10.2 AGTR1 EDN1
34 cerebritis 10.2
35 aortic aneurysm 10.2
36 subacute leukemia 10.2 ACE EDN1 NOS3
37 patent ductus arteriosus 10.2
38 hypoaldosteronism, congenital, due to cmo ii deficiency 10.2 AGT CYP11B2
39 renal clear cell carcinoma 10.1 ACE AGTR1 CYP11B2
40 bubonic plague 10.1 AGTR1 EDN1 NOS3
41 cataract, autosomal dominant congenital 4 10.1 ACE AGT AGTR1
42 potato nose 10.1 ACE AGT AGTR1
43 placental abruption 10.1 ACE ADRB1
44 adenocarcinoma 10.1 ACE AGT AGTR1
45 retinitis pigmentosa 17 10.1 ACE AGT AGTR1
46 fibular aplasia ectrodactyly 10.1 ACE AGT AGTR1
47 cascade stomach 10.1 ACE AGT AGTR1
48 physical urticaria 10.1 EDN1 FBN1
49 renal tubular dysgenesis 10.1 ACE AGT AGTR1
50 hypertrichosis of eyelid 10.1 ACE ADRB1 AGTR1

Graphical network of the top 20 diseases related to Aortic Coarctation:



Diseases related to Aortic Coarctation

Symptoms & Phenotypes for Aortic Coarctation

MGI Mouse Phenotypes related to Aortic Coarctation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
2 growth/size/body region MP:0005378 10.1 ACE ADRB1 ADRB2 AGT AGTR1 CYP11B2
3 adipose tissue MP:0005375 10.08 ADRB2 AGT AGTR1 CYP11B2 FBN1 NOS3
4 homeostasis/metabolism MP:0005376 10.07 ADRB1 ADRB2 AGT AGTR1 CYP11B2 EDN1
5 endocrine/exocrine gland MP:0005379 10.03 ACE ADRB1 ADRB2 CYP11B2 EDN1 FBN1
6 mortality/aging MP:0010768 9.96 ACE ADRB1 AGT AGTR1 EDN1 FBN1
7 immune system MP:0005387 9.92 ACE ADRB2 AGT AGTR1 CYP11B2 FBN1
8 muscle MP:0005369 9.7 NOS3 NOTCH1 ADRB1 ADRB2 AGT EDN1
9 nervous system MP:0003631 9.61 ADRB2 AGT AGTR1 CYP11B2 EDN1 FBN1
10 renal/urinary system MP:0005367 9.23 ACE AGT AGTR1 CYP11B2 EDN1 FBN1

Drugs & Therapeutics for Aortic Coarctation

Drugs for Aortic Coarctation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anticholesteremic Agents Phase 4,Phase 3
2 Antimetabolites Phase 4,Phase 3,Early Phase 1
3 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3
4 Hypolipidemic Agents Phase 4,Phase 3,Early Phase 1
5 Lipid Regulating Agents Phase 4,Phase 3,Early Phase 1
6 Calcium, Dietary Phase 4,Phase 2
7 Atorvastatin Calcium Phase 4 134523-03-8
8
Ezetimibe Approved Phase 3 163222-33-1 150311
9
Simvastatin Approved Phase 3 79902-63-9 54454
10
Alendronate Approved Phase 2 121268-17-5, 66376-36-1 2088
11
Denosumab Approved Phase 2 615258-40-7
12
Nitric Oxide Approved Phase 2 10102-43-9 145068
13
Nitroglycerin Approved, Investigational Phase 2 55-63-0 4510
14
Nitroprusside Approved Phase 2 15078-28-1 11963622
15
Sevoflurane Approved, Vet_approved Phase 2 28523-86-6 5206
16
Menadione Approved, Nutraceutical Phase 2 58-27-5 4055
17
Phytonadione Approved, Nutraceutical Phase 2 84-80-0 4812 5284607
18 Bone Density Conservation Agents Phase 2
19 Anesthetics Phase 2,Phase 1
20 Anesthetics, General Phase 2
21 Anesthetics, Inhalation Phase 2
22 Antihypertensive Agents Phase 2
23 Central Nervous System Depressants Phase 2,Phase 1
24 Nitric Oxide Donors Phase 2
25 Platelet Aggregation Inhibitors Phase 2
26 Vasodilator Agents Phase 2,Early Phase 1
27 Coagulants Phase 2
28 Hemostatics Phase 2
29 Vitamins Phase 2,Early Phase 1
30 Antifibrinolytic Agents Phase 2
31 Micronutrients Phase 2,Early Phase 1
32 Trace Elements Phase 2,Early Phase 1
33 Vitamin K 2 Phase 2
34 Vitamin MK 7 Phase 2
35 Menaquinone Nutraceutical Phase 2
36 naphthoquinone Nutraceutical Phase 2
37 Vitamin K Nutraceutical Phase 2
38
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
39
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
40 Analgesics Phase 1
41 Anesthetics, Local Phase 1
42 Antiemetics Phase 1
43 Anti-Inflammatory Agents Phase 1
44 Antineoplastic Agents, Hormonal Phase 1
45 Autonomic Agents Phase 1
46 BB 1101 Phase 1
47 Dexamethasone acetate Phase 1 1177-87-3
48 Gastrointestinal Agents Phase 1
49 glucocorticoids Phase 1
50 HIV Protease Inhibitors Phase 1

Interventional clinical trials:

(show all 49)

id Name Status NCT ID Phase Drugs
1 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
2 Statins and Endothelial Function in Patients With Coarctation of the Aorta Terminated NCT00767572 Phase 4 atorvastatin;Sugar pill
3 The Effect of Lipitor on Aortic Stenosis Terminated NCT00590135 Phase 4 atorvastatin (Lipitor)
4 An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED) Completed NCT00092677 Phase 3 ezetimibe (+) simvastatin;Comparator: Placebo
5 Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis. Unknown status NCT02132026 Phase 2 Denosumab;Alendronic Acid;Denosumab Placebo;Alendronic Acid Placebo
6 Covered CP Stents for the Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta Completed NCT01278303 Phase 2
7 Effect of Strategy for Blood Pressure Control on Cerebral Oxygen Balance During Aortic Coarctation Repair: A Randomized Study Completed NCT00535808 Phase 2 nitroprusside;nitroglycerine;sevoflurane
8 Bicuspid Aortic Valve Stenosis and the Effect of vItamin K2 on Calciummetabolism on 18F-NaF PET/MRI Recruiting NCT02917525 Phase 2
9 The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta Completed NCT03074773 Phase 1 Dexamethasone;Bupivacaine
10 Radiation-Free Heart Catheterization Using MRI Recruiting NCT02739087 Phase 1
11 Proof of Concept of Model Based Cardiovascular Prediction Unknown status NCT02591940
12 T1 Mapping of Diffuse Myocardial Fibrosis in Congenital Heart Disease Unknown status NCT02350829
13 Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis Unknown status NCT01358513
14 Coarctation Of the Aorta Stent Trial Completed NCT00552812
15 MRI Assessment of RV Function: Patients With TOF or Aortic Coarctation Completed NCT00277901
16 Large Diameter Advanta™ V12 Covered Stent Trial for Coarctation of the Aorta Completed NCT00978952
17 Evaluation of Image-Based Modelling on Clinical Decisions in Coarctation of the Aorta Completed NCT02700737
18 Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast Magnetic Resonance Imaging (MRI) Completed NCT00722904
19 A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt Completed NCT01340378
20 Cerebral Perfusion During Neonatal Cardiac Surgery Completed NCT01032876
21 Bupropion & Cardio Birth Defect (Slone) Completed NCT01597661 Exposure to any bupropion during the first trimester;Exposure to bupropion alone during the first trimester
22 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
23 Study of the Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery Completed NCT02325765
24 National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Completed NCT01322165
25 Reproduction and Survival After Cardiac Defect Repair Completed NCT00005190
26 Microvascular Dysfunction in Aortic Stenosis Completed NCT01658345
27 Acquired Von Willebrand Syndrome in Severe Aortic Stenosis Completed NCT00805051
28 Pilot Study of Cognitive and Functional Outcomes Following TAVI Completed NCT02089945
29 Regression of Myocardial Fibrosis After Aortic Valve Replacement Completed NCT02174471
30 The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery Completed NCT00348920
31 Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants Recruiting NCT02835703
32 Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment Recruiting NCT03262753
33 Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance Recruiting NCT02161471
34 Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions Recruiting NCT02545790
35 National Congenital Heart Disease Audit Recruiting NCT02303535
36 Genetic Analysis of PHACE Syndrome (Hemangioma With Other Congenital Anomalies) Recruiting NCT01016756
37 Early Aortic Valve Lipoprotein(a) Lowering Trial Recruiting NCT02109614 Early Phase 1 Extended release Niacin;Placebo Comparator
38 Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics Recruiting NCT01118442
39 Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS Recruiting NCT03094143
40 Quality of Care in AS IMPULSE Study Recruiting NCT02241447
41 Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue Bank Recruiting NCT02706639
42 Validation of a Predictive Model of Coronary Fractional Flow Reserve in Patients With Intermediate Coronary Stenosis Recruiting NCT03054324
43 JenaValve Pericardial TAVR System Aortic Stenosis Study Active, not recruiting NCT02732691
44 Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease Enrolling by invitation NCT03147014
45 Antenatal Diagnosis of Coarctations of the Aorta. Not yet recruiting NCT03303768
46 The Relationship Between ALDH2 and Aortic Dissection Not yet recruiting NCT02630212
47 Surgical Outcomes in Pediatric Patients With Coarctation and VSD Terminated NCT00327795
48 Aortic Arch Reconstruction Terminated NCT00277940
49 A Comparison of Advanced Imaging Techniques in Aortic Stenosis Withdrawn NCT01775215

Search NIH Clinical Center for Aortic Coarctation

Genetic Tests for Aortic Coarctation

Anatomical Context for Aortic Coarctation

MalaCards organs/tissues related to Aortic Coarctation:

39
Heart, Kidney, Endothelial, Bone, Brain, Spinal Cord, Testes

Publications for Aortic Coarctation

Articles related to Aortic Coarctation:

(show top 50) (show all 645)
id Title Authors Year
1
Intravascular Treatment of Left Subclavian Artery Aneurysm Coexisting with Aortic Coarctation in an Adult Patient. ( 28401193 )
2017
2
Results of a multimodal approach for the management of aortic coarctation and its complications in adults. ( 28498970 )
2017
3
Percutaneous management of complex acquired aortic coarctation in an adult with tetralogy of Fallot and pulmonary atresia. ( 28928619 )
2017
4
Left Ventricular Fibrosis and Systolic Hypertension Persist in a Repaired Aortic Coarctation Model. ( 28554563 )
2017
5
Immediate and longa89term outcomes of native aortic coarctation and postsurgical aortic recoarctation treated with stent implantation: a singlea89center experience. ( 28724880 )
2017
6
Percutaneous treatment of adult aortic coarctation with multiple intrathoracic aneurysms. ( 28647035 )
2017
7
The outcome of isolated prenatal ventricular size disproportion in the absence of aortic coarctation. ( 28598570 )
2017
8
Staged open repair for a complex adult aortic coarctation. ( 28833633 )
2017
9
How successful is successful? Aortic arch shape after successful aortic coarctation repair correlates with left ventricular function. ( 27776913 )
2017
10
Multidirectional WSS disturbances in stenotic turbulent flows: A pre- and post-intervention study in an aortic coarctation. ( 27919417 )
2017
11
Pulmonary artery dissection complicating aortic dissection in a patient with bicuspid aortic valve and aortic coarctation. ( 28828104 )
2017
12
Stent Therapy for Aortic Coarctation in Children <30A kg: Use of the Low Profile Valeo Stent. ( 28780709 )
2017
13
Direct Common Carotid Artery Puncture for Endovascular Treatment of Acute Large Vessel Ischemic Stroke in a Patient with Aortic Coarctation. ( 28844548 )
2017
14
Long-term outcomes after aortic coarctation repair in Maltese patients: A population-based study. ( 28580660 )
2017
15
Double-outlet left ventricle with a bicuspid pulmonary valve and aortic coarctation. ( 28881023 )
2017
16
Assessment of cerebral blood flow in adult patients with aortic coarctation. ( 28566094 )
2017
17
Is the medical treatment for arterial hypertension after primary aortic coarctation repair related to age at surgery? A retrospective cohort study. ( 28595675 )
2017
18
Aortic, Coarctation ( 28613663 )
2017
19
Aortic Coarctation Repair: How I Teach It. ( 28734405 )
2017
20
Beyond Pressure Gradients: The Effects of Intervention on Heart Power in Aortic Coarctation. ( 28081162 )
2017
21
Hemangioma, aortic coarctation and intracranial dolichoectasia: PHACE syndrome. ( 28211225 )
2017
22
A systematic review and meta-analysis of exercise and exercise hypertension in patients with aortic coarctation. ( 28770819 )
2017
23
Left ventricular noncompaction associated with bicuspid aortic valve and aortic coarctation. ( 28522032 )
2017
24
Virtual 3-Dimensional Computed Tomographic Surgical Planning for Severe Aortic Coarctation/Aneurysm in the Setting of Bicuspid Aortic Valve. ( 28033077 )
2017
25
Mycotic aneurysm of the root of left subclavian artery associated with aortic coarctation discovered by echocardiography. ( 28681536 )
2017
26
Single Stage Repair for Aortic Coarctation associated with Intracardiac Defects Using Extra-Anatomic Bypass Graft in Adults. ( 27482266 )
2016
27
De Novo Migraine With Aura After Surgical Repair of Aortic Coarctation. ( 27910096 )
2016
28
Effectiveness of Balloon Angioplasty in Children With Recurrent Aortic Coarctation Depends on the Type of Aortic Arch Pathology. ( 27358058 )
2016
29
Thoracic Stent Graft Implantation for Aortic Coarctation with Patent Ductus Arteriosus via Retroperitoneal Iliac Approach in the Presence of Small Sized Femoral Artery. ( 27242935 )
2016
30
Double Invasive Blood Pressure Monitoring for Cesarean Delivery in a Pregnant Woman With Aortic Coarctation. ( 27310898 )
2016
31
Three-dimensional rotational angiography in children with an aortic coarctation. ( 27659792 )
2016
32
Growing potential of small aortic valve with aortic coarctation or interrupted aortic arch after bilateral pulmonary artery banding. ( 27371606 )
2016
33
Aortic Coarctation 28 Days after an Arterial Switch Operation in a Neonate. ( 27547151 )
2016
34
COAST-ing Toward Covered Stents forA Aortic Coarctation: Not All Plain Sailing! ( 26896891 )
2016
35
Surgical management of aortic coarctation in adolescents and adults. ( 28011739 )
2016
36
Acute Clinical Presentation of Pseudoaneurysm and Aortopulmonary Fistula as a Very Late Complication of Aortic Coarctation Patch Repair. ( 27659858 )
2016
37
Balloon Dilatation and Stenting for Aortic Coarctation: A Systematic Review and Meta-Analysis. ( 27296199 )
2016
38
3D Geometric Analysis of the Pediatric Aorta in 3D MRA Follow-Up Images with Application to Aortic Coarctation. ( 27405687 )
2016
39
Aortic coarctation, aneurysm, and ventricular dysfunction in an asymptomatic infant. ( 26980403 )
2016
40
Endovascular Treatment of a Complicated Acute Type B Aortic Dissection in a Patient With Aortic Coarctation. ( 27720668 )
2016
41
Giant Aneurysm in a Patient With Noncorrected and Longstanding Aortic Coarctation. ( 27000618 )
2016
42
Previously undetected severe aortic coarctation in an adult: value of MRI. ( 27018811 )
2016
43
A 2-Step Extra-Anatomic Bypass Rescue Procedure for Bridging Aortic Coarctation in a Patient With Multiorgan Failure. ( 26927010 )
2016
44
Balloon angioplasty of severe aortic coarctation in a newborn, using axillary artery access: The first experience in Turkey. ( 27774972 )
2016
45
On-Pump Beating Heart Extraanatomical Ascending-Descending Aortic Bypass Using a Beating Heart Positioner in an Adult with Aortic Coarctation. ( 27087874 )
2016
46
Aortic coarctation disclosed in a middle-aged hypertensive patient by tardus parvus waveform in renal Doppler ultrasonography. ( 27910079 )
2016
47
Multimodality imaging of aortic coarctation: From the fetus to the adolescent. ( 27132712 )
2016
48
Collateral Aneurysms in Aortic Coarctation. A Contraindication for Percutaneous Intervention? ( 28034685 )
2016
49
MRI as a tool for non-invasive vascular profiling: a pilot study in patients with aortic coarctation. ( 27227178 )
2016
50
MRI-based computational hemodynamics in patients with aortic coarctation using the lattice Boltzmann methods: Clinical validation study. ( 27384018 )
2016

Variations for Aortic Coarctation

Expression for Aortic Coarctation

Search GEO for disease gene expression data for Aortic Coarctation.

Pathways for Aortic Coarctation

Pathways related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 ADRB1 ADRB2 AGT EDN1 GNB3
2
Show member pathways
12.48 AGT AGTR1 EDN1 GNB3 NOS3
3 12.24 ADRB1 ADRB2 GNB3 NOTCH1
4
Show member pathways
11.99 ACE AGT GNB3
5
Show member pathways
11.9 AGT AGTR1 GNB3
6 11.84 ADRB1 ADRB2 GNB3
7
Show member pathways
11.84 ADRB1 ADRB2 GNB3 GRK4 NOS3
8
Show member pathways
11.83 ADRB1 ADRB2 AGTR1 NOS3
9 11.79 AGTR1 GNB3 NOS3
10 11.73 ADRB1 ADRB2 GNB3
11 11.58 AGTR1 EDN1 NOS3
12 10.95 AGTR1 FBN1
13 10.93 AGT EDN1
14 10.87 ADRB1 ADRB2
15 10.86 ADRB1 EDN1 NOS3
16 10.83 ACE ADRB1 ADRB2 AGT AGTR1

GO Terms for Aortic Coarctation

Biological processes related to Aortic Coarctation according to GeneCards Suite gene sharing:

(show all 38)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.9 ADRB1 ADRB2 AGT EDN1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 AGT AGTR1 EDN1
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.68 AGT AGTR1
4 brown fat cell differentiation GO:0050873 9.67 ADRB1 ADRB2
5 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.67 AGTR1 EDN1
6 kidney development GO:0001822 9.67 ACE AGT AGTR1 FBN1
7 vasodilation GO:0042311 9.66 AGT NOS3
8 positive regulation of cardiac muscle hypertrophy GO:0010613 9.65 AGT EDN1
9 regulation of sodium ion transport GO:0002028 9.65 ADRB2 NOS3
10 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.65 ADRB1 ADRB2
11 vasoconstriction GO:0042310 9.64 AGT EDN1
12 nitric oxide mediated signal transduction GO:0007263 9.64 AGT NOS3
13 positive regulation of cellular protein metabolic process GO:0032270 9.63 AGT AGTR1
14 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.63 AGT AGTR1
15 low-density lipoprotein particle remodeling GO:0034374 9.62 AGT AGTR1
16 positive regulation of renal sodium excretion GO:0035815 9.62 AGT EDN1
17 negative regulation of multicellular organism growth GO:0040015 9.61 ADRB1 ADRB2
18 angiotensin maturation GO:0002003 9.61 ACE AGT
19 blood vessel remodeling GO:0001974 9.61 ACE AGT NOS3
20 artery smooth muscle contraction GO:0014824 9.59 AGT EDN1
21 diet induced thermogenesis GO:0002024 9.58 ADRB1 ADRB2
22 positive regulation of cholesterol esterification GO:0010873 9.58 AGT AGTR1
23 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.56 EDN1 NOS3
24 positive regulation of NAD(P)H oxidase activity GO:0033864 9.55 AGT AGTR1
25 renin-angiotensin regulation of aldosterone production GO:0002018 9.54 AGT AGTR1
26 regulation of renal sodium excretion GO:0035813 9.52 AGT AGTR1
27 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure GO:0002025 9.51 ADRB1 ADRB2
28 regulation of blood vessel size GO:0050880 9.5 AGT EDN1 NOS3
29 heat generation GO:0031649 9.49 ADRB1 ADRB2
30 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.48 AGT AGTR1
31 regulation of extracellular matrix assembly GO:1901201 9.46 AGT NOTCH1
32 regulation of renal output by angiotensin GO:0002019 9.4 ACE AGT
33 posttranscriptional regulation of gene expression GO:0010608 9.36 MATR3
34 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 ACE AGT AGTR1
35 regulation of blood vessel diameter GO:0097746 9.26 ACE AGTR1
36 regulation of vasoconstriction GO:0019229 9.26 ACE AGT AGTR1 EDN1
37 regulation of blood pressure GO:0008217 9.02 ACE AGT EDN1 GNB3 NOS3
38 G-protein coupled receptor signaling pathway GO:0007186 10.04 ADRB1 ADRB2 AGT AGTR1 EDN1 GNB3

Molecular functions related to Aortic Coarctation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.67 ADRB1 ADRB2 AGTR1 GNB3
2 hormone activity GO:0005179 9.43 AGT EDN1 FBN1
3 adrenergic receptor activity GO:0004935 9.32 ADRB1 ADRB2
4 epinephrine binding GO:0051379 9.16 ADRB1 ADRB2
5 norepinephrine binding GO:0051380 8.96 ADRB1 ADRB2
6 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Aortic Coarctation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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