Aortic Valve Stenosis malady

Disease Ontology: Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. the aortic valve controls the direction of blood flow from the left ventricle to the aorta. when in good working order, the aortic valve does not impede the flow of blood between these two spaces. under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. this is known as aortic valve stenosis, or aortic stenosis, often abbreviated as.⁶

MalaCards: Aortic Valve Stenosis, also known as aortic stenosis, is related to congenital aortic valve stenosis and alzheimer's disease. An important gene associated with Aortic Valve Stenosis is L3MBTL1 (l(3)mbt-like 1 (Drosophila)), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Cardiomyocyte Differentiation through BMP Receptors. The compounds nitroglycerin and glucose have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Wikipedia: Aortic valve stenosis (AS) is a disease of the heart valves in which the opening of the aortic valve is...⁴⁴ more...

Aliases & Descriptions:

aortic valve stenosis 6 30 8 43 aortic stenosis 6 32

aortic valve stenosis (disorder) 6 as 6

Diseases related to aortic valve stenosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 3618)

id	Related Disease	Score	Top Affiliating Genes
1	congenital aortic valve stenosis	34.3	L3MBTL1, JAG1, ADRB2, ADRB1
2	alzheimer's disease	33.3	APOE, ACE, ADRB2
3	asthma	33.3	MME, KNG1, ADRB2
4	colorectal cancer	32.9	VDR, APOE, TNF, TLR2
5	supravalvular aortic stenosis	32.7	LIMK1, GTF2I, GTF2IRD1, PDLIM1, ELN
6	myocardial infarction	32.3	MMP2, APOB, APOE, ACE
7	renal cell carcinoma	30.8	MME, MMP2, MMP9, FLT1, TNC, NPPC
8	sepsis	30.0	CCL2, HSPD1, TNF, CRP, PLTP, NOS3
9	venous thrombosis	29.6	VWF, APOB, F8, PLAT
10	thromboembolism	29.5	VWF, APOA1, F8, PLAT, NOS3
11	cardiac rupture	29.4	MMP9, CRP, PLAT, NPPB
12	osteogenesis imperfecta	28.9	BMP2, CD36, TNC, GGT1
13	muscular dystrophy	28.7	VWF, BGN, MMP2, HSPD1, NOS1, ACE
14	pulmonary hypertension	28.5	BMP2, FLT1, TNC, NOS3, EDN1, ELN
15	periodontitis	28.3	VDR, CD36, MMP9, CCL2, HSPD1, TNF
16	inflammatory bowel disease	28.2	VDR, VCAM1, CCL2, HSPD1, TNF, CRP
17	angioedema	28.2	MME, PLAT, ACE, PON1, KNG1
18	hemophilia	28.2	VWF, FBN1, F8, TNF, TNFRSF11B
19	systemic lupus erythematosus	28.1	VWF, VCAM1, FBN1, CCL2, F8, HSPD1
20	cushing's syndrome	28.0	VWF, CD36, TNFRSF11B, PLAT, NOS3
21	ovarian carcinoma	28.0	VDR, CD36, MME, MMP2, MMP9, FLT1
22	liver cirrhosis	27.9	LPA, TNFRSF11B, EDN1, TLR2, NPPA, NPPC
23	epithelial ovarian cancer	27.9	VDR, BMP2, CD36, MMP2, MMP9, FLT1
24	lung carcinoma	27.8	BMP2, MME, MMP2, MMP9, FLT1, HSPD1
25	carpal tunnel syndrome	27.8	CD36, CCL2, TNC, ELN
26	protein s deficiency	27.7	MGP, APOA1, APOB, APOE, F8, PLTP
27	ehlers-danlos syndrome	27.7	BGN, CD36, FBN1, TNC, ELN
28	parkinson's disease	27.7	VDR, APOE, CCL2, TNF, CRP, NOS1
29	autonomic dysfunction	27.6	MME, APOA1, CRP, NPPB
30	prostate carcinoma	27.6	VDR, BMP2, CD36, MMP2, MMP9, TNC
31	septic shock	27.6	TNF, CRP, NOS3, TLR2, NPPB, NPPC
32	myelofibrosis	27.6	BMP2, F8, TNF, TNFRSF11B, AHSG
33	retinoblastoma	27.6	VDR, BMP2, L3MBTL1, MMP2, MMP9, FLT1
34	hyperparathyroidism	27.6	VWF, VDR, BMP2, CD36, TNF, TNFRSF11B
35	hypercalcemia	27.5	VDR, CD36, MGP, TNF, TNFRSF11B, CRP
36	cholangiocarcinoma	27.5	VDR, BMF, MME, MMP2, MMP9, MGP
37	endometrial carcinoma	27.5	VDR, VCAM1, MME, MMP2, MMP9, FLT1
38	myeloid leukemia	27.4	VWF, VDR, L3MBTL1, JAG1, CD36, MMP2
39	thyroid carcinoma	27.4	VDR, CD36, MMP2, MMP9, FLT1, CCL2
40	sleep apnea	27.4	NPPB, KNG1, ADRB2
41	ectopic pregnancy	27.4	VCAM1, FLT1, HSPD1, TLR2
42	fatty liver disease	27.4	CD36, APOA1, APOB, TNF, CRP, PLTP
43	abdominal aortic aneurysm	27.3	MMP2, MMP9, FBN1, CCL2, TNFRSF11B, ELN
44	marfan syndrome	27.3	CD36, MMP2, FBN1, ELN, KNG1
45	neurodegenerative disease	27.3	MME, MMP2, APOE, TNF, PLTP, NOS1
46	retinol binding protein	27.2	LPA, APOA1, CCL2, TNF, CRP, ACE
47	acute promyelocytic leukemia	27.2	VWF, VDR, BMP2, CCL2, TNF, PLAT
48	hemochromatosis	27.2	BMP2, APOE, CCL2, TNF, ACE
49	spina bifida	27.2	APOB, APOE, CCL2, NOS1, NOS3, PON1
50	sudden infant death syndrome	27.2	BMP2, MME, APOE, TNF, EDN1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to aortic valve stenosis:

²²

MGI Mouse Phenotypes related to aortic valve stenosis:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.3	GGT1, NPR1, TLR2, FKBP6
2	hematopoietic system phenotype	MP:0005397	10.2	NPR2, FBN1, JAG1, L3MBTL1, BMF
3	integument phenotype	MP:0010771	9.6	TLR2, CORIN, DLX5, FBN1, GTF2IRD1, MME
4	craniofacial phenotype	MP:0005382	9.5	NPR2, NPPC, EDN1, DLX5, FBN1, GTF2IRD1
5	liver/biliary system phenotype	MP:0005370	9.4	HGD, TLR2, NOS3, APOB, APOA1, CD36
6	no phenotypic analysis	MP:0003012	9.1	ADRB1, ADRB2, AGER, FBN1, GTF2I, JAG1
7	renal/urinary system phenotype	MP:0005367	9.0	HGD, NPPA, ACE2, CORIN, NOS3, MAS1
8	respiratory system phenotype	MP:0005388	8.8	NPR2, NPR1, ELN, ACE2, NOS1, DLX5
9	pigmentation phenotype	MP:0001186	8.7	CORIN, CCL2, APOE, APOB, FBN1, GTF2IRD1
10	hearing/vestibular/ear phenotype	MP:0005377	8.6	EDN1, PLAT, DLX5, TNFRSF11B, TNC, APOE
11	other phenotype	MP:0005395	8.5	TLR2, NOS3, NOS1, APOE, FBN1, MME
12	skeleton phenotype	MP:0005390	8.4	HGD, BGN, BMP2, VDR, LECT1, JAG1
13	limbs/digits/tail phenotype	MP:0005371	8.3	TNFRSF11B, DLX5, NPPC, NPR2, GGT1, APOE
14	nervous system phenotype	MP:0003631	7.9	MAS1, TNC, DLX5, NOS1, EDN1, TLR2
15	reproductive system phenotype	MP:0005389	7.6	NPR2, NPR1, PLTP, TNF, HSPD1, F8
16	adipose tissue phenotype	MP:0005375	7.2	ADRB1, ADRB2, TLR2, ACE, NOS3, NOS1
17	immune system phenotype	MP:0005387	7.2	TNF, PLAT, NOS1, AGER, NPR1, NPR2
18	digestive/alimentary phenotype	MP:0005381	6.9	DLX5, PLAT, NOS1, NOS3, EDN1, TLR2
19	behavior/neurological phenotype	MP:0005386	6.9	PLAT, NOS1, NOS3, ACE, AGER, TLR2
20	vision/eye phenotype	MP:0005391	6.6	TNF, DLX5, PLAT, PLTP, NOS1, NOS3
21	growth/size phenotype	MP:0005378	6.5	ADRB2, FBN1, MGP, GTF2IRD1, GTF2I, JAG1
22	muscle phenotype	MP:0005369	4.8	ADRB1, ADRB2, NPR2, NPR1, NPPB, NPPA
23	cardiovascular system phenotype	MP:0005385	2.0	BMP2, VCAM1, VDR, VWF, ADRB1, ADRB2
24	homeostasis/metabolism phenotype	MP:0005376	INF	PON1, TLR2, AHSG, AGER, ELN, ACE2
25	mortality/aging	MP:0010768	INF	GGT1, ADRB1, NPR2, TNF, , HSPD1
26	cellular phenotype	MP:0005384	INF	TNFRSF11B, DLX5, PLAT, NOS1, NOS3, CORIN

Articles related to aortic valve stenosis:

(show all 29)

id	Title	Authors	Year	Affiliating Genes
1	Tumor necrosis factor-I+ accelerates the calcification of human aortic valve interstitial cells obtained from patients with calcific aortic valve stenosis via the BMP2-Dlx5 pathway. (21205918)	Yu Z.... Furukawa K.	2011	TNF, BMP2, DLX5
2	(Pro)renin receptors and angiotensin converting enzym e 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis. (21316680)	Peltonen T.... Taskinen P.	2011	ACE2, ATP6AP2, MAS1
3	Calcium metabolism in adults with severe aortic valve stenosis and preserved renal function. (20211333)	Akat K.... Ortlepp J.R.	2010	TNFRSF11B
4	Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2. (20382708)	Derbali H.... Mathieu P.	2010	TLR2, PLTP, BGN
5	Paraoxonase activity might be predictive of the sever ity of aortic valve stenosis. (20845892)	Cagirci G.... Akdemir R.	2010	PON1
6	Circulating soluble receptor for advanced glycation e nd-product levels are decreased in patients with calcific aortic valve stenosis . (20074734)	Basta G.... Mazzone A.	2010	AGER
7	Increase in tissue endothelin-1 and ETA receptor levels in human aortic valve stenosis. (19008257)	Peltonen T.... Ruskoaho H.	2009	EDN1
8	Usefulness of serial brain natriuretic peptide measur ements for managing aortic valve stenosis in pregnancy. (19633743)	Patel S.... Choi J.W.	2009	NPPB
9	Correlates of valvular ossification in patients with aortic valve stenosis. (20443935)	Ing S.W.... Leonard M.B.	2009	MGP
10	Serum gamma-glutamyltransferase activity is increased in patients with calcific aortic valve stenosis. (18751465)	Bozbas H.... Muderrisoglu H.	2008	GGT1
11	Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling. (18179910)	Della Corte A.... Cotrufo M.	2008	BMF
12	Systemic and local levels of fetuin-A in calcific aortic valve stenosis. (17611637)	Kaden J.J.... Ortlepp J.R.	2007	AHSG
13	Time course of C-reactive protein, tumour necrosis factor-alpha and monocyte chemoattractant protein-1 following the surgical treatment of patients with aortic valve stenosis. (17388104)	Kastellanos S.S.... Stefanadis C.I.	2007	CCL2
14	Distinct downregulation of C-type natriuretic peptide system in human aortic valve stenosis. (17709640)	Peltonen T.O.... Leskinen H.	2007	NPR1, NPR2, NPPB
15	Type I and type III collagen synthesis and composition in the valve matrix in aortic valve stenosis. (16405893)	Eriksen H.A.... Soini Y.	2006	CD36
16	Chemically modified tetracyclines (CMT-3 and CMT-8) enable control of the pathologic remodellation of human aortic valve stenosis via MMP-9 and VEGF inhibition. (16242193)	Salo T.... Satta J.	2006	MMP2, MMP9
17	Relation of circulating C-reactive protein to progression of aortic valve stenosis. (16377290)	SA!nchez P.L.... Martin-Luengo C.	2006	CRP
18	Postinfarction cardiac rupture despite immediate reperfusion therapy in a patient with severe aortic valve stenosis. (16440151)	Tanaka M.... Nonogi H.	2006	PLAT
19	Transcardiac gradients of N-terminal B-type natriuretic peptide in aortic valve stenosis. (16087135)	Kupari M.... Parikka H.	2005	NPPB
20	Effects of angiotensin converting enzyme inhibitors in hypertensive patients with aortic valve stenosis: a drug withdrawal study. (16162624)	JimAcnez-Candil J.... GarcA-a-FernA!ndez M.A.	2005	ACE
21	Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis. (15120829)	Mazzone A.... Tanganelli P.	2004	VCAM1, HSPD1
22	Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis. (14506635)	Soini Y.... Satta J.	2003	FLT1, NOS3, NOS1
23	Can serum lipid and CRP levels predict the 'severity' of aortic valve stenosis? (12948037)	Gunduz H.... Uyan C.	2003	CRP
24	Progression of human aortic valve stenosis is associated with tenascin-C expression. (11755293)	Satta J.... Soini Y.	2002	TNC
25	Neutral endopeptidase is activated in cardiomyocytes in human aortic valve stenosis and heart failure. (11804980)	Fielitz J.... Regitz-Zagrosek V.	2002	MME, KNG1
26	The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. (11359741)	Ortlepp J.R.... Hanrath P.	2001	VDR
27	Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis. (11903341)	Avakian S.D.... Mansura A.P.	2001	APOE, APOA1, APOB
28	Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis. (10982545)	Pareti F.I.... Ruggeri Z.M.	2000	VWF
29	Neurohormonal profile in aortic valve stenosis (8291934)	Ramirez-Gil J.F.... Thomas D.	1993	EDN1, NPPA

Genes related to aortic valve stenosis according to GeneCards:

(show top 50)    (show all 58)

id	Symbol	Description	Score	GeneCards Section Context
1	L3MBTL1	l(3)mbt-like 1 (Drosophila)	11.0
2	MAS1	MAS1 oncogene	11.0	Publications
3	ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	11.0	Publications
4	BMF	Bcl2 modifying factor	11.0	Publications
5	MGP	matrix Gla protein	11.0	Publications
6	BGN	biglycan	11.0	Publications
7	DLX5	distal-less homeobox 5	11.0	Publications
8	FKBP6	FK506 binding protein 6, 36kDa	11.0
9	NPPC	natriuretic peptide C	11.0	Publications
10	AHSG	alpha-2-HS-glycoprotein	11.0	Publications
11	NPR2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	11.0	Publications
12	LECT1	leukocyte cell derived chemotaxin 1	11.0
13	NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	11.0	Publications
14	PLTP	phospholipid transfer protein	11.0	Publications
15	LIMK1	LIM domain kinase 1	11.0
16	PDLIM1	PDZ and LIM domain 1	11.0
17	ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	11.0	Publications
18	HGD	homogentisate 1,2-dioxygenase	11.0
19	GTF2IRD1	GTF2I repeat domain containing 1	11.0
20	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
21	JAG1	jagged 1	11.0
22	ADRB1	adrenoceptor beta 1	11.0
23	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
24	CORIN	corin, serine peptidase	11.0	Publications
25	LPA	lipoprotein, Lp(a)	11.0	Publications
26	GGT1	gamma-glutamyltransferase 1	11.0	Publications
27	MME	membrane metallo-endopeptidase	11.0	Publications
28	NPPB	natriuretic peptide B	11.0	Publications
29	GTF2I	general transcription factor IIi	11.0
30	PON1	paraoxonase 1	11.0	Publications
31	TNC	tenascin C	11.0	Publications
32	BMP2	bone morphogenetic protein 2	11.0	Publications
33	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
34	VWF	von Willebrand factor	11.0	Publications
35	NPPA	natriuretic peptide A	11.0	Publications
36	TLR2	toll-like receptor 2	11.0	Publications
37	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
38	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
39	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
40	PLAT	plasminogen activator, tissue	11.0	Publications
41	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Publications
42	EDN1	endothelin 1	11.0	Publications
43	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
44	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
45	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
46	APOA1	apolipoprotein A-I	11.0	Publications
47	ADRB2	adrenoceptor beta 2, surface	11.0
48	ELN	elastin	11.0
49	F8	coagulation factor VIII, procoagulant component	11.0	Publications
50	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications

Pathways related to aortic valve stenosis according to GeneDecks:

(show all 15)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.4	ATP6AP2, ACE2, MAS1, MME
2	Cardiomyocyte Differentiation through BMP Receptors36	10.0	BMP2, NPPA, NPPB
3	Renin-angiotensin system20	10.0	ACE2, ACE, MAS1, MME
4	Endothelin-1 Signaling Pathway36	9.6	BMP2, FLT1, NOS1, EDN1
5	Blood Coagulation Signaling Pathways37	9.6	KNG1, PLAT, F8, VWF
6	LDL Oxidation in Atherogenesis36	9.6	VCAM1, CD36, CCL2, TNF
7	Statin Pathway, Pharmacodynamics34	9.5	PLTP, APOE, APOB, APOA1
8	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.4	KNG1, ACE2, ACE, NOS3, MAS1, MME
9	Malaria20	9.4	VCAM1, CD36, CCL2, TNF, TLR2
10	Angiogenesis3	9.1	JAG1, MMP2, MMP9, FLT1, NOS3
11	Inhibition of Angiogenesis by TSP136	9.0	ELN, TNC, FBN1, MMP9, CD36
12	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.0	VDR, APOE, TNF, TNFRSF11B
13	Selected targets of HNF110	8.9	ACE2, CRP, F8, APOB, APOA1, LPA
14	Metalloproteases in connective tissue degradation10	8.9	MMP2, MMP9, TNC, ELN
15	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.9	TNFRSF11B, TNF, APOE, VDR

Compounds related to aortic valve stenosis according to GeneDecks:

(show top 50)    (show all 328)

id	Compound	Score	Top Affiliating Genes
1	nitroglycerin32 9 9	12.7	NPR1, TNFRSF11B
2	glucose32	10.5	MME, AHSG
3	atenolol32 9 18 9	13.1	ADRB1, ADRB2
4	isoproterenol32 9 9	12.1	ADRB1, ADRB2, NPPA
5	sodium nitroprusside32	9.4	KNG1, NPR2, NPR1, NPPC, NPPB, NPPA
6	l-nmma32	9.2	NPPB, NPPA, EDN1, NOS1, VCAM1, KNG1
7	ascorbic acid32 18	10.0	BMP2, VDR, CD36, MME, MMP2, NOS1
8	pioglitazone32 9 9	11.0	MMP2, VCAM1, MMP9, NPPB, APOA1, APOB
9	enalaprilat32	8.9	KNG1, NPPB, NPPA, ACE2, ACE, EDN1
10	pge232	8.9	TNFRSF11B, APOA1, MME, BMP2, VCAM1, NOS1
11	captopril32 42 9 9	11.9	ACE2, ACE, APOB, APOA1, MMP2, KNG1
12	omapatrilat32	8.8	ACE, EDN1, PLAT, MMP9, MME, NPPA
13	fluvastatin32 34 9 9	11.7	PON1, NOS3, PLAT, CCL2, APOB, APOA1
14	cysteine32	8.6	PLTP, PLAT, FBN1, MMP9, MMP2, VDR
15	pravastatin32 34 9 18 9	12.0	APOB, APOA1, BMP2, LPA, APOE, CCL2
16	perindopril32 34 9 9	10.7	VWF, CRP, PLAT, NOS3, KNG1, NPPB
17	aspartate32	7.7	APOE, APOA1, MMP9, MMP2, VDR, F8
18	testosterone32 9 18 9	10.7	TNFRSF11B, APOE, APOA1, MMP9, MMP2, MME
19	8-isoprostane32	7.6	NPPB, PON1, EDN1, NOS3, CRP, TNF
20	fenofibrate32 9 9	9.6	VCAM1, LPA, MMP9, APOA1, APOB, PON1
21	fibrinogen32	7.6	PON1, TLR2, AHSG, VCAM1, LPA, APOA1
22	heparin32 9 18 9	10.4	KNG1, NPPC, AGER, ELN, TNFRSF11B, TNC
23	indomethacin32 9 9	9.3	PLAT, TNFRSF11B, TNF, HSPD1, APOE, APOA1
24	tgf beta132	7.1	ELN, TNFRSF11B, TNF, TNC, F8, CCL2
25	homocysteine32 18	7.9	VWF, TNFRSF11B, F8, CCL2, APOE, APOB
26	losartan32 34 9 9	9.8	CRP, CCL2, APOE, CD36, VCAM1, VWF
27	acetylcholine32 9 18 9	9.7	VWF, MME, CRP, GGT1, ADRB2, KNG1
28	sb 20358032 42	7.7	NPPB, EDN1, NOS3, NOS1, CRP, VDR
29	rosiglitazone32 9 18 9	9.7	TNF, CCL2, APOE, APOB, MMP9, MMP2
30	actinomycin d32	6.5	BMP2, MME, MMP9, APOE, CCL2, VDR
31	arginine32	6.5	GGT1, CCL2, APOE, FBN1, MME, BMP2
32	cyclosporin a32 42	7.5	VDR, VWF, APOE, BMP2, MME, NPPB
33	simvastatin32 34 42 9 18 9	11.4	APOA1, MMP9, BMP2, VCAM1, LPA, VWF
34	norepinephrine32 9 18 9	9.4	EDN1, NOS1, CRP, F8, CCL2, MMP9
35	calcium32 9 18 9	9.2	AHSG, AGER, ELN, EDN1, PDLIM1, NOS1
36	aspirin32 34 18	8.2	ADRB2, KNG1, VDR, LPA, VWF, MMP2
37	retinoic acid32 42 18	8.1	ADRB1, NPPC, TLR2, ELN, NOS3, NOS1
38	genistein32 9 18 9	9.0	MMP9, MMP2, CD36, BMP2, VCAM1, VDR
39	dexamethasone32 42 34 9 9	9.9	TNF, VCAM1, VDR, VWF, BMP2, BGN
40	atorvastatin32 34 9 18 9	9.8	NPPB, PON1, EDN1, NOS3, PLAT, CRP
41	cholesterol32 9 18 9	8.7	GGT1, PON1, TLR2, AGER, ACE2, FLT1
42	nitric oxide32 9 18 9	8.7	NPPA, CCL2, FLT1, MME, JAG1, BMP2
43	creatinine32	5.4	EDN1, CRP, TNFRSF11B, TNC, HSPD1, F8
44	prostacyclin32	5.4	NPPA, AGER, ACE, EDN1, NOS3, PLAT
45	alanine32	5.0	APOA1, FBN1, MMP9, MMP2, BMP2, VCAM1
46	cycloheximide32	4.9	HSPD1, CCL2, APOE, APOB, MMP9, MMP2
47	estrogen32	4.7	NPPB, APOA1, FBN1, MGP, FLT1, MMP9
48	lipid32	4.4	GGT1, ADRB1, ADRB2, NPPC, NPPB, PON1
49	vegf32	3.6	ADRB2, NPPB, NPPA, F8, CCL2, APOE
50	serine32	2.9	NPPB, PON1, TLR2, AGER, ELN, CORIN

Cellular components related to aortic valve stenosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	9.6	AHSG, PLAT, TNC, FBN1, MGP, BGN
2	apical part of cell	GO:045177	9.5	NOS3, PLAT, JAG1, VCAM1
3	very-low-density lipoprotein particle	GO:034361	9.4	APOA1, APOB, APOE
4	cell surface	GO:009986	8.8	TLR2, ACE2, CORIN, PLAT, TNF, HSPD1
5	external side of plasma membrane	GO:009897	8.8	TLR2, ACE, TNF, CD36, ATP6AP2, VCAM1
6	proteinaceous extracellular matrix	GO:005578	8.6	ELN, TNFRSF11B, TNC, FBN1, MGP, MMP9
7	integral to plasma membrane	GO:005887	8.1	AGER, TLR2, NPR1, ADRB2, ADRB1, CORIN
8	plasma membrane	GO:005886	5.3	CORIN, ACE, ACE2, AGER, TLR2, NPR2
9	extracellular region	GO:005576	4.3	KNG1, NPPC, NPPB, APOE, APOB, APOA1
10	extracellular space	GO:005615	3.6	KNG1, CCL2, APOE, APOB, APOA1, FBN1

Biological processes related to aortic valve stenosis according to GeneDecks:

(show all 39)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of inflammatory response	GO:050727	10.5	GGT1, AHSG, ACE2, MAS1
2	cGMP biosynthetic process	GO:006182	10.4	NPR2, NPR1, NPPC, NPPB, NPPA
3	receptor guanylyl cyclase signaling pathway	GO:007168	10.4	NPR2, NPR1, NPPC, NPPB, NPPA
4	body fluid secretion	GO:007589	10.3	EDN1, NPPB, NPR1
5	regulation of blood vessel size	GO:050880	10.3	NOS3, NPPA, NPPB, NPPC, NPR1
6	blood vessel remodeling	GO:001974	10.3	ELN, NOS3, BGN
7	negative regulation of hydrolase activity	GO:051346	10.2	APOA1, NOS1, NOS3
8	negative regulation of angiogenesis	GO:016525	10.2	NPR1, NPPB, CCL2, GTF2I, LECT1
9	positive regulation of vasodilation	GO:045909	10.1	ADRB2, NPPC, NOS3, NOS1
10	regulation of vasodilation	GO:042312	10.1	NPR1, NPPB, ACE2, ACE
11	positive regulation of renal sodium excretion	GO:035815	10.1	KNG1, NPR1, NPPB, EDN1
12	positive regulation of urine volume	GO:035810	10.1	KNG1, NPR1, NPPB, EDN1
13	positive regulation of cGMP biosynthetic process	GO:030828	10.0	NPR1, NPPC, APOE
14	regulation of vasoconstriction	GO:019229	10.0	NPPC, ACE2, ACE, EDN1
15	ossification	GO:001503	10.0	MMP9, MGP, AHSG, NPPC, NPR2
16	cholesterol transport	GO:030301	9.9	CD36, APOA1, APOB
17	aging	GO:007568	9.8	ADRB1, NOS3, CCL2, VCAM1, VDR
18	positive regulation of interleukin-6 production	GO:032755	9.8	TLR2, TNF, HSPD1, CD36
19	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	TLR2, NOS3, TNF, CCL2
20	regulation of blood pressure	GO:008217	9.6	NPR2, NPR1, NPPC, NPPB, NPPA, ACE
21	cell surface receptor signaling pathway	GO:007166	9.6	ADRB2, NPR2, NPR1, NPPB, AGER, EDN1
22	negative regulation of growth of symbiont in host	GO:044130	9.6	CD36, TNF, TLR2
23	blood coagulation, intrinsic pathway	GO:007597	9.5	KNG1, F8, VWF
24	lipoprotein metabolic process	GO:042157	9.5	APOE, APOB, APOA1, LPA
25	response to heat	GO:009408	9.5	NOS3, NOS1, CCL2, MMP9
26	heart development	GO:007507	9.5	VCAM1, BMP2, FBN1, EDN1, NPPB
27	platelet degranulation	GO:002576	9.4	KNG1, F8, APOA1, CD36, VWF
28	negative regulation of blood coagulation	GO:030195	9.4	KNG1, EDN1, APOE
29	organ morphogenesis	GO:009887	9.4	ELN, TNF, CCL2, BMP2, VDR
30	skeletal system development	GO:001501	9.3	AHSG, DLX5, TNFRSF11B, FBN1, MMP9, LECT1
31	receptor-mediated endocytosis	GO:006898	9.3	ADRB2, APOE, APOB, LPA
32	response to mechanical stimulus	GO:009612	9.2	NOS3, TNF, CCL2, MGP, MMP9, BMP2
33	lipid metabolic process	GO:006629	9.2	PLTP, APOE, APOB, APOA1, CD36, LPA
34	response to drug	GO:042493	8.8	NPPC, NPPB, EDN1, NOS3, TNFRSF11B, TNF
35	positive regulation of apoptotic process	GO:043065	8.7	ADRB2, KNG1, NOS3, TNF, HSPD1, MMP9
36	blood coagulation	GO:007596	8.6	KNG1, NOS3, NOS1, PLAT, F8, APOB
37	inflammatory response	GO:006954	8.3	KNG1, NPPB, TLR2, AGER, CRP, TNF
38	proteolysis	GO:006508	8.2	ACE2, ACE, CORIN, PLAT, MMP9, MMP2
39	response to hypoxia	GO:001666	7.0	VCAM1, NPPC, NPPB, EDN1, PDLIM1, NOS3

Molecular functions related to aortic valve stenosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide hormone receptor binding	GO:051428	10.1	NPPC, NPPB, NPPA
2	extracellular matrix structural constituent	GO:005201	9.7	BGN, MGP, FBN1, ELN
3	Gram-positive bacterial cell surface binding	GO:051637	9.3	CD36, CRP, TLR2
4	receptor binding	GO:005102	9.1	KNG1, NPPC, NPPB, NPPA, TNC, CCL2
5	heparin binding	GO:008201	8.6	KNG1, CCL2, APOE, APOB, LPA
6	protein binding	GO:005515	3.1	GGT1, F8, HSPD1, TNF, CRP, PLAT