Summaries for Aphasia

Sources:
6Disease Ontology, 23MedlinePlus, 31NINDS, 44Wikipedia, 22MalaCards
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MedlinePlus: Aphasia is a disorder caused by damage to the parts of the brain that control language. it can make it hard for you to read, write and say what you mean to say. it is most common in adults who have had a stroke. brain tumors, infections, injuries and dementia can also cause it. the type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. there are four main types: expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean receptive aphasia - you hear the voice or see the print, but you can't make sense of the words anomic aphasia - you have trouble using the correct word for objects, places or events global aphasia - you can't speak, understand speech, read or write some people recover from aphasia without treatment. most, however, need language therapy as soon as possible. nih: national institute of neurological disorders and stroke23

MalaCards: Aphasia is related to primary progressive aphasia and logopenic progressive aphasia. An important gene associated with Aphasia is L1CAM (L1 cell adhesion molecule), and among its related pathways are Alzheimers Disease Pathway and Neuroscience. The compounds thioflavin and tmao have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are nervous system and no phenotypic analysis.

Disease Ontology: A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.6

NINDS: Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language. Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Most commonly seen in adults who have suffered a stroke, aphasia can also result from a brain tumor, infection, head injury, or dementia that damages the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue.31

Wikipedia: Aphasia (pron.: /əˈfeɪʒə/ or /əˈfeɪziə/ or /eɪˈfeɪziə/, from ancient Greek ἀφασία...44 more...

Aliases & Descriptions for Aphasia

Sources:
6Disease Ontology, 31NINDS, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS
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aphasia 6 31 8 32 23 43

Related Diseases for Aphasia

Sources:
13GeneCards, 14GeneDecks
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Diseases related to aphasia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1primary progressive aphasia34.0RPS27A, MAPT, GRN
2logopenic progressive aphasia33.0SNCA, MAPT
3nominal aphasia31.8SLC22A7, CA11
4apraxia29.3COPS2, CBS, MAPT, GRN, BRAP
5semantic dementia28.2TARDBP, RPS27A, MAPT, APOE, GRN
6corticobasal degeneration28.0MAPT, SNCA, RPS27A, TARDBP
7progressive supranuclear palsy26.8LRRK2, RPS27A, SNCA, MAPT, APOE
8supranuclear palsy26.4PRNP, LRRK2, RPS27A, SNCA, MAPT, APP
9frontotemporal dementia25.7SNCB, SNCA, RPS27A, LRRK2, C9orf72, TARDBP
10dementia24.7RPS27A, LRRK2, C9orf72, TARDBP, PRNP, SMUG1
11frontotemporal dementia, ubiquitin-positive13.6SNCA, MAPT
12perry syndrome13.6TARDBP, GRN
13frontotemporal lobar degeneration with ubiquitin-positive inclusions13.6TARDBP, RPS27A, GRN
14gerstmann-straussler-scheinker disease13.6PRNP, APP
15lewy body dementia13.6SNCA, SNCB
16neuroaxonal dystrophy, infantile13.6RPS27A, APP
17parkinson disease type 313.6MAPT, SNCA, LRRK2
18early-onset familial alzheimer disease13.5SNCA, MAPT, APP
19rem sleep behavior disorder13.5RPS27A, SNCA
20inclusion body myositis13.5RPS27A, MAPT, APP
21niemann-pick disease type c113.5APP, MAPT, SNCA
22neuronal intranuclear inclusion disease13.5RPS27A, SNCA, MAPT
23prion disease13.5APP, MAPT, PRNP
24familial idiopathic basal ganglia calcification13.5MAPT, APP
25fibrillary astrocytoma13.5APP, SNCB, SNCA
26lateral sclerosis13.5SNCA, MAPT
27olivopontocerebellar atrophy13.5MAPT, SNCA, RPS27A
28niemann–pick disease13.4SNCA, MAPT, APP
29movement disease13.4LRRK2, RPS27A, SNCA, MAPT
30amyotrophic lateral sclerosis with frontotemporal dementia13.4TARDBP, C9orf72, RPS27A, GRN
31neuroaxonal dystrophy13.4RPS27A, SNCA
32inclusion body myopathy13.4TARDBP, RPS27A, SNCA, APP
33parkinson disease 1013.4LRRK2, SNCA
34gaze palsy13.4TARDBP, SNCA, HOXA1, MAPT
35aicardi-goutieres syndrome13.4PRNP, SNCA, MAPT, APP
36autonomic dysfunction13.3RPS27A, SNCA, MAPT
37differentiating neuroblastoma13.3RPS27A, SNCA, MAPT, APP
38dysgraphia13.3COPS2, BRAP
39tauopathy13.2LRRK2, RPS27A, SNCA, MAPT, APP, GRN
40basal ganglia calcification13.1MAPT, APP
41gliosis13.1PRNP, C9orf72, RPS27A, SNCA, MAPT, APP
42hemiplegia12.9PLAT, FEV, IQCB1
43brain ischemia12.9RPS27A, PLAT, MAPT, APP
44cerebral amyloid angiopathy12.9APP, APOE
45alzheimer disease type 112.9APOE, APP, MAPT
46familial creutzfeldt-jakob disease12.9PRNP, APOE
47cognitive disease12.8MAPT, APP, APOE
48alzheimer disease type 212.8APOE, APP, MAPT
49cerebral atrophy12.8APOE, MAPT, RPS27A
50alzheimer's disease12.8PRNP, MAPT, APP, APOE

Graphical network of the top 20 diseases related to aphasia:



Graphical network of diseases related to aphasia

Clinical Features for Aphasia

Drugs & Therapeutics for Aphasia

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Aphasia

Anatomical Context for Aphasia

Sources:
22MalaCards
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MalaCards organs/tissues related to aphasia:

22
Brain

Phenotypes for genes affiliated with Aphasia

Sources:
25MGI
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MGI Mouse Phenotypes related to aphasia:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1nervous system phenotypeMP:00036318.8LRRK2, SNCA, HOXA1, FEV, ISL2, FUS
2no phenotypic analysisMP:00030127.6SEMA3A, PRNP, TARDBP, LRRK2, SNCA, SNCB
3growth/size phenotypeMP:00053786.1CBS, SNCB, SNCA, PLAT, TARDBP, MAPT
4behavior/neurological phenotypeMP:00053865.9CBS, HOXA1, SNCA, PLAT, LRRK2, TARDBP
5cellular phenotypeMP:00053845.7HOXA1, SNCA, PLAT, COPS2, LRRK2, TARDBP
6mortality/agingMP:00107685.1HOXA1, SNCB, SNCA, PLAT, COPS2, LRRK2

Publications for genes affiliated with Aphasia

Sources:
35PubMed
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Articles related to aphasia:

(show all 13)
idTitleAuthorsYearAffiliating Genes
1Cerebrospinal fluid tau, p-tau 181 and amyloid-I^38/40 /42 in frontotemporal dementias and primary progressive aphasias. (21135556)Bibl M.... Wiltfang J.2011APP, MAPT
2The APOE gene locus in frontotemporal dementia and pr imary progressive aphasia. (21555637)Seripa D.... Masullo C.2011APOE
3A novel MAPT mutation associated with the clinical ph enotype of progressive nonfluent aphasia. (21558644)Villa C.... Galimberti D.2011MAPT
4Phenomenology and anatomy of abnormal behaviours in p rimary progressive aphasia. (20400120)Rohrer J.D.... Warren J.D.2010GRN
5Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation. (20479359)Gliebus G.... Geula C.2010GRN
6The northwestern anagram test: measuring sentence pro duction in primary progressive aphasia. (19700669)Weintraub S.... Thompson C.K.2009TARDBP
7APOE epsilon 2/epsilon 4 genotype a risk factor for p rimary progressive aphasia in women. (19597098)Daniele A.... Masullo C.2009APOE
8Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. (17914064)Chen-Plotkin A.S.... Van Deerlin V.M.2008LRRK2
9Apraxia of speech and nonfluent aphasia: a new clinical marker for corticobasal degeneration and progressive supranuclear palsy. (18989114)Josephs K.A.... Duffy J.R.2008MAPT
10Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families. (17210807)Mesulam M.... Graff-Radford N.R.2007GRN
11Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia. (16315279)Li X.... Mastrianni J.A.2005PRNP
12Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia. (15804056)Yancopoulou D.... Spillantini M.G.2005MAPT, SNCA, SNCB
13Possible association of the tau H1/H1 genotype with primary progressive aphasia. (12629248)Sobrido M.J.... Geschwind D.H.2003MAPT

Expression for genes affiliated with Aphasia

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Aphasia

Pathways for genes affiliated with Aphasia

Sources:
36QIAGEN, 3Cell Signaling Technology
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Pathways related to aphasia according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1Alzheimers Disease Pathway369.4APOE, APP, MAPT
2Neuroscience39.3APP, MAPT, SNCB, SNCA, LRRK2, TARDBP

Compounds for genes affiliated with Aphasia

Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
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Compounds related to aphasia according to GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1thioflavin32 10.4APP, MAPT, SNCA
2tmao32 10.1MAPT, SNCA
3tacrine32 9 9 11.7APOE, APP, MAPT
4donepezil32 9 18 9 12.7MAPT, APP, APOE
5thioflavin t32 9.7SNCA, APP, APOE
6galantamine32 34 9 9 12.6APOE, APP, MAPT
7guanidine32 9 18 9 12.6PRNP, MAPT, APOE
8metrifonate32 9.5APOE, APP
9guanidine hydrochloride32 9.5PRNP, RPS27A, SNCA, APOE
10thioflavine s32 9.5APOE, APP, MAPT, SNCA, RPS27A
11chloroquine32 34 9 9 12.4RPS27A, MAPT, APP, APOE
124-hydroxynonenal32 18 10.4RPS27A, SNCA, MAPT, APP, APOE
13lactacystin32 9.4APOE, APP, MAPT, SNCA, RPS27A
14formate32 9.3PRNP, RPS27A, SNCA, MAPT, APP, APOE
15sodium dodecylsulfate32 9.3PRNP, RPS27A, SNCA, MAPT, APP, APOE
16valine32 9.3PRNP, RPS27A, SNCA, MAPT, APP, APOE
1724s-hydroxy-cholesterol32 9.2APP, APOE
18spec-t32 9.1PLAT, MAPT, APOE
19dopamine32 9 18 9 12.0LRRK2, RPS27A, SNCA, MAPT, APP, APOE
20nmda32 42 9.8APOE, APP, MAPT, CBS, RPS27A
21paraffin32 8.8PRNP, RPS27A, PLAT, SNCA, MAPT, APOE
22h2o232 8.6PRNP, RPS27A, SNCA, SNCB, CBS, MAPT
23glutamate32 8.1PRNP, RPS27A, PLAT, SNCA, CBS, MAPT

GO Terms for genes affiliated with Aphasia

Sources:
12Gene Ontology
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Cellular components related to aphasia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.4SEMA3A, APP, MAPT, SNCA
2synapseGO:0452029.1LGI1, APP, SNCA, PLAT

Biological processes related to aphasia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:0358729.9UBA52, APP, RPS27A
2regulation of locomotionGO:0400129.9SNCA, LRRK2
3anti-apoptosisGO:0069168.9PRNP, RPS27A, SNCA, APOE, UBA52
4cell deathGO:0082198.7L1CAM, FUS, APOE, C9orf72, TARDBP

Molecular functions related to aphasia according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin conjugating enzyme bindingGO:0316249.8ZMYM2, MARCH6
2protein bindingGO:0055154.8KIF24, HOXA1, SNCA, SMUG1, PLAT, COPS2

Sources for Aphasia

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS