MCID: APH002
MIFTS: 44

Aphasia malady

Genetic diseases, Fetal diseases, Rare diseases, Neuronal diseases categories

Summaries for Aphasia

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Sources:
9Disease Ontology, 35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Aphasia is a disorder caused by damage to the parts of the brain that control language. it can make it hard for you to read, write, and say what you mean to say. it is most common in adults who have had a stroke. brain tumors, infections, injuries, and dementia can also cause it. the type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. there are four main types: expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean receptive aphasia - you hear the voice or see the print, but you can't make sense of the words anomic aphasia - you have trouble using the correct word for objects, places, or events global aphasia - you can't speak, understand speech, read, or write some people recover from aphasia without treatment. most, however, need language therapy as soon as possible. nih: national institute of neurological disorders and stroke

MalaCards: Aphasia is related to primary progressive aphasia and apraxia. An important gene associated with Aphasia is L1CAM (L1 cell adhesion molecule). The compounds tmao and sodium dodecylsulfate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are no phenotypic analysis and nervous system.

Disease Ontology:9 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.

NINDS:45 Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language. Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Most commonly seen in adults who have suffered a stroke, aphasia can also result from a brain tumor, infection, head injury, or dementia that damages the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue.

Wikipedia:66 Aphasia (/??fe???/, /??fe?zi?/ or /e??fe?zi?/) is a disturbance of the comprehension and expression of... more...

Aliases & Classifications for Aphasia

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Sources:
9Disease Ontology, 45NINDS, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Fetal diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

aphasia 9 45 11 46 35 63


External Ids:

Disease Ontology9 DOID:0060046

Related Diseases for Aphasia

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Primary Progressive Aphasia family:

aphasia

Diseases related to Aphasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 353)
idRelated DiseaseScoreTop Affiliating Genes
1primary progressive aphasia31.6GRN, MAPT
2apraxia30.9GRN, MAPT
3dementia30.9MAPT, GRN, APOC1, TARDBP
4semantic dementia30.8GRN, MAPT
5frontotemporal dementia30.7MAPT, GRN, TARDBP
6alzheimer's disease30.4TOMM40, APOC1, MAPT, GRN, TARDBP
7progressive supranuclear palsy30.4TARDBP, MAPT, GRN
8pick's disease30.3TARDBP, MAPT
9frontotemporal lobar degeneration with ubiquitin-positive inclusions30.3GRN
10tauopathy29.9GRN, MAPT
11memory impairment29.8APOC1, MAPT, GRN
12amyotrophic lateral sclerosis29.8MAPT, TARDBP, GRN
13motor neuron disease29.6MAPT, GRN, TARDBP
14landau-kleffner syndrome10.6
15logopenic progressive aphasia10.5
16progressive non-fluent aphasia10.5
17agnosia10.4
18alexia10.4
19corticobasal degeneration10.4
20nominal aphasia10.3
21cerebritis10.3
22blindness10.2
23ideomotor apraxia10.2
24dysgraphia10.1
25gerstmann syndrome10.1
26spastic paraplegia 110.1
27anosognosia10.1
28encephalitis10.1
29lateral sclerosis10.0
30auditory agnosia10.0
31associative agnosia10.0
32amusia10.0
33neuronitis10.0
34creutzfeldt-jakob disease10.0
35anterior cerebral artery infarction10.0
36epilepsy syndrome10.0
37hemiplegia10.0
38seizure disorder10.0
39hydrocephalus10.0MAPT, L1CAM
40x-linked ichthyosis9.9
41mutism9.9
42dyslexia9.9
43typhoid fever9.9
44moyamoya disease9.9
45transient global amnesia9.9
46galactosemia9.9
47learning disability9.9
48meningitis9.9
49foix chavany marie syndrome9.9
50marchiafava bignami disease9.9

Graphical network of the top 20 diseases related to Aphasia:



Diseases related to aphasia

Symptoms for Aphasia

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Drugs & Therapeutics for Aphasia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Aphasia

Drug clinical trials:

Search ClinicalTrials for Aphasia

Search NIH Clinical Center for Aphasia

Search CenterWatch for Aphasia

Genetic Tests for Aphasia

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Anatomical Context for Aphasia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Aphasia:

34
Brain, Testes, Cortex, Temporal lobe, Skin, Prefrontal cortex, Parietal lobe

Animal Models for Aphasia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Aphasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6TARDBP, GRN, MAPT, L1CAM
2MP:00036318.6TARDBP, GRN, MAPT, L1CAM
3MP:00053868.5L1CAM, MAPT, GRN, TARDBP
4MP:00053848.3L1CAM, MAPT, GRN, TARDBP

Publications for Aphasia

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Sources:
53PubMed
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Articles related to Aphasia:

(show top 50)    (show all 834)
idTitleAuthorsYear
1
Options to enhance recovery from aphasia by means of non-invasive brain stimulation and action observation therapy. (24308276)
2014
2
Learning to fail in aphasia: an investigation of error learning in naming. (23816662)
2013
3
The World Report on Disability as a blueprint for international, national, and local aphasia services. (23101515)
2013
4
Neural systems underlying the influence of sound shape properties of the lexicon on spoken word production: do fMRI findings predict effects of lesions in aphasia? (23743183)
2013
5
Aphasia Predicts Unfavorable Outcome in Mild Ischemic Stroke Patients and Prompts Thrombolytic Treatment. (23352114)
2013
6
Non-invasive brain stimulation (rTMS and tDCS) in patients with aphasia: mode of action at the cellular level. (23872450)
2013
7
Young patient with aphasia, monoparesis, facial drop, facial sensory loss, diplopia, dysarthria, and vertical gaze palsy. (24130136)
2013
8
Writing treatment for aphasia: a texting approach. (23811474)
2013
9
Handedness and language learning disability differentially distribute in progressive aphasia variants. (24056533)
2013
10
Clinical genetic study of the epilepsy-aphasia spectrum. (23294109)
2013
11
Prediction of aphasia outcome using diffusion tensor tractography for arcuate fasciculus in stroke. (23042924)
2013
12
Identification of an atypical variant of logopenic progressive aphasia. (23566690)
2013
13
White matter in aphasia: a historical review of the Dejerines' studies. (23895939)
2013
14
Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia. (23395096)
2013
15
Classification and pathology of primary progressive aphasia. (24142474)
2013
16
Steps to success with technology for individuals with aphasia. (22851345)
2012
17
FOXP2, APOE, and PRNP: new modulators in primary progressive aphasia. (22129783)
2012
18
Aphasia rehabilitation: more than treating the language disorder. (22119073)
2012
19
Crossed aphasia in a dextral patient with logopenic/phonological variant of primary progressive aphasia. (21959362)
2012
20
Non-verbal communication in severe aphasia: influence of aphasia, apraxia, or semantic processing? (21458789)
2012
21
Prolonged ictal aphasia: a diagnosis to consider. (22925412)
2012
22
Borderzone strokes and transcortical aphasia. (21904919)
2011
23
Computer-Mediated Assessment of Intelligibility in Aphasia and Apraxia of Speech. (22215933)
2011
24
Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation. (20479359)
2010
25
Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia. (20400120)
2010
26
From singing to speaking: facilitating recovery from nonfluent aphasia. (21088709)
2010
27
Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanism. (18679537)
2008
28
Foreign accent syndrome as the initial sign of primary progressive aphasia. (17635973)
2008
29
Visuomotor tracking abilities of speakers with apraxia of speech or conduction aphasia. (18558428)
2008
30
Primary progressive aphasia: relationship between gender and severity of language impairment. (17356343)
2007
31
A review on primary progressive aphasia. (19300609)
2007
32
A cocaine-associated quadriplegia and motor aphasia after first use of cocaine. (17724897)
2007
33
The mini-mental state examination in behavioral variant frontotemporal dementia and primary progressive aphasia. (18166606)
2007
34
Primary progressive aphasia: a case report. (17965034)
2007
35
Apoe epsilon2-epsilon4 genotype is a possible risk factor for primary progressive aphasia. (16437577)
2006
36
A case study of Primary Progressive Aphasia: improvement on verbs after rTMS treatment. (17182394)
2006
37
Different patterns of Mini Mental Status Examination responses in primary progressive aphasia and Alzheimer's disease. (16987166)
2006
38
Aphasia, alexia, and oral reading. (14872397)
2004
39
Deterioration of naming nouns versus verbs in primary progressive aphasia. (14755731)
2004
40
Primary progressive aphasia: a review. (15849155)
2004
41
Acquired alexia in multilingual aphasia and computer-assisted treatment in both languages: issues of generalisation and transfer. (11316940)
2001
42
Frontotemporal decreases in rCBF correlate with degree of dysnomia in primary progressive aphasia. (10688104)
2000
43
Aphasia in corticobasal degeneration. (10624476)
2000
44
An autopsy case of Alzheimer's disease presenting with primary progressive aphasia: a clinicopathological and immunohistochemical study. (11132942)
2000
45
Developmental delay, expressive aphasia, hypotonia and dysmorphism in two brothers: an X-linked mental retardation syndrome? (9843001)
1998
46
Primary progressive aphasia and frontal lobe involvement. (8559410)
1996
47
Dissociation of anosognosia for hemiplegia and aphasia during left-hemisphere anesthesia. (7824138)
1995
48
Acquired aphasia with seizure disorder in childhood. (2473957)
1989
49
Wernicke's and global aphasia without alexia. (435133)
1979
50
Aphasia, apraxia, and agnosia; a new classification. (21017997)
1946

Variations for Aphasia

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Expression for genes affiliated with Aphasia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aphasia

Search GEO for disease gene expression data for Aphasia.

Pathways for genes affiliated with Aphasia

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Compounds for genes affiliated with Aphasia

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank
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Compounds related to Aphasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tmao469.4APOC1, MAPT
2sodium dodecylsulfate469.2APOC1, MAPT
3antivirals for treatment of hiv infections, combinations529.1APOC1, TOMM40
4ritonavir46 52 1211.0APOC1, TOMM40
5glucose468.9APOC1, MAPT, GRN
6estrogen468.6APOC1, MAPT, GRN

GO Terms for genes affiliated with Aphasia

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Sources:
17Gene Ontology
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Biological processes related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082199.1TARDBP, GRN, L1CAM

Products for genes affiliated with Aphasia

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  • Antibodies
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Sources for Aphasia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet