MCID: APH002
MIFTS: 49

Aphasia malady

Summaries for Aphasia

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Aphasia is a disorder caused by damage to the parts of the brain that control language. it can make it hard for you to read, write, and say what you mean to say. it is most common in adults who have had a stroke. brain tumors, infections, injuries, and dementia can also cause it. the type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. there are four main types: expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean receptive aphasia - you hear the voice or see the print, but you can't make sense of the words anomic aphasia - you have trouble using the correct word for objects, places, or events global aphasia - you can't speak, understand speech, read, or write some people recover from aphasia without treatment. most, however, need language therapy as soon as possible. nih: national institute of neurological disorders and stroke

MalaCards: Aphasia is related to dementia and frontotemporal dementia. An important gene associated with Aphasia is L1CAM (L1 cell adhesion molecule), and among its related pathways is Neuroscience. The compounds tmao and thioflavin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are pigmentation and no phenotypic analysis.

Disease Ontology:8 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.

NINDS:43 Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language. Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Most commonly seen in adults who have suffered a stroke, aphasia can also result from a brain tumor, infection, head injury, or dementia that damages the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue.

Wikipedia:63 Aphasia (/əˈfeɪʒə/, /əˈfeɪziə/ or /eɪˈfeɪziə/), from ancient Greek ἀφασία... more...

Aliases & Classifications for Aphasia

About this section
Sources:
8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS
See all sources

Aliases & Descriptions:

aphasia 8 43 10 44 33 60


External Ids:

Disease Ontology8 DOID:0060046

Related Diseases for Aphasia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Primary Progressive Aphasia family:

aphasia

Diseases related to Aphasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 381)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9RPS27A, APP, SNCB, SNCA, PRNP, GRN
2frontotemporal dementia30.6LRRK2, TARDBP, MAPT, GRN, CHMP2B, SNCA
3alzheimer's disease30.5RPS27A, APP, SNCB, SNCA, PRNP, GRN
4primary progressive aphasia30.5MAPT, GRN, RPS27A
5progressive supranuclear palsy30.3GRN, MAPT, TARDBP
6pick's disease30.2RPS27A, APP, SNCA, MAPT, TARDBP
7frontotemporal lobar degeneration with ubiquitin-positive inclusions30.0GRN
8semantic dementia30.0MAPT, GRN, RPS27A
9encephalitis30.0LGI1, APP
10lateral sclerosis29.9SNCA, MAPT
11tauopathy29.8RPS27A, APP, SNCA, GRN, MAPT, LRRK2
12amyotrophic lateral sclerosis29.8RPS27A, APP, SNCA, PRNP, CHMP2B, GRN
13neuronal intranuclear inclusion disease29.6RPS27A
14lewy body dementia29.6SNCB, SNCA
15brain disease29.6APP, SNCA, PRNP, MAPT
16motor neuron disease29.6RPS27A, SNCA, GRN, MAPT, TARDBP
17parkinson's disease29.6RPS27A, SNCB, SNCA, MAPT, LRRK2
18apraxia10.6
19landau-kleffner syndrome10.5
20agnosia10.4
21alexia10.4
22logopenic progressive aphasia10.4
23cerebritis10.3
24nominal aphasia10.3
25progressive non-fluent aphasia10.2
26ideomotor apraxia10.1
27epilepsy syndrome10.1
28visual agnosia10.1
29gerstmann syndrome10.1
30dysgraphia10.1
31stroke, ischemic10.0
32anosognosia10.0
33auditory agnosia10.0
34spastic paraplegia 110.0
35neuroblastoma10.0PRNP
36rem sleep behavior disorder10.0SNCA
37hydrocephalus10.0MAPT, L1CAM
38schizophrenia10.0SNCA
39scrapie10.0MAPT, PRNP
40gastrointestinal stromal tumor10.0SMUG1
41lrrk2-related parkinson disease10.0LRRK2
42neuroaxonal dystrophy, infantile10.0RPS27A, APP
43spinocerebellar ataxia type 310.0SNCA, RPS27A
44gerstmann-straussler-scheinker disease10.0PRNP, APP
45parkinson disease type 310.0LRRK2, MAPT, SNCA
46cerebral amyloid angiopathy10.0MAPT, PRNP, APP
47down syndrome10.0MAPT, SNCA, APP
48niemann-pick disease10.0APP, SNCA, MAPT
49inclusion body myositis10.0RPS27A, APP, MAPT
50prion disease10.0MAPT, PRNP, APP

Graphical network of the top 20 diseases related to Aphasia:



Diseases related to aphasia

Clinical Features for Aphasia

About this section

Drugs & Therapeutics for Aphasia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aphasia

Drug clinical trials:

Search ClinicalTrials for Aphasia

Search NIH Clinical Center for Aphasia

Search CenterWatch for Aphasia

Genetic Tests for Aphasia

About this section

Anatomical Context for Aphasia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Aphasia:

32
Brain, Testes, Cortex, Temporal lobe, Skin, Prefrontal cortex, Parietal lobe

Animal Models for Aphasia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Aphasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.0L1CAM, GRN, LRRK2, LGI1
2MP:00030129.3ISL2, LRRK2, L1CAM, TARDBP, HOXA1, MAPT
3MP:00053869.1PRNP, SNCA, L1CAM, LRRK2, LGI1, TARDBP
4MP:00053769.1GRN, FEV, APP, SNCB, SNCA, PRNP
5MP:00036319.0L1CAM, FEV, ISL2, APP, GRN, SNCB
6MP:00053849.0APP, SMUG1, LRRK2, TARDBP, HOXA1, MAPT
7MP:00053789.0ISL2, LGI1, TARDBP, MAPT, PRNP, SNCA
8MP:00107688.8SNCB, APP, FEV, L1CAM, LGI1, SNCA

Publications for Aphasia

About this section
Sources:
50PubMed
See all sources

Articles related to Aphasia:

(show top 50)    (show all 839)
idTitleAuthorsYear
1
Hidden word learning capacity through orthography in aphasia. (24262200)
2014
2
White matter in aphasia: a historical review of the Dejerines' studies. (23895939)
2013
3
Neuroimaging in aphasia treatment research: consensus and practical guidelines for data analysis. (22387474)
2013
4
Adaptation to aphasia: grammar, prosody and interaction. (23237417)
2013
5
Verbal and visuospatial span in logopenic progressive aphasia and Alzheimer's disease. (23298815)
2013
6
Recovery of aphasia after stroke: a 1-year follow-up study. (22820721)
2013
7
Transcranial direct current stimulation (tDCS) of Broca's area in chronic aphasia: a controlled outcome study. (23538068)
2013
8
Neural substrate responsible for crossed aphasia. (24133361)
2013
9
Examining language functions: a reassessment of Bastian's contribution to aphasia assessment. (23803303)
2013
10
An evaluation of treatment integrity in a randomized trial of behavioural therapy for low mood in stroke patients with aphasia. (23881337)
2013
11
Repetitive deep transcranial magnetic stimulation improves verbal fluency and written language in a patient with primary progressive aphasia-logopenic variant (LPPA). (23122915)
2013
12
Aphasia rehabilitation: more than treating the language disorder. (22119073)
2012
13
Aphasia: early classification, evaluation of existing therapy, and novel therapeutics. (23086178)
2012
14
Progressive aphasia presenting with deep dyslexia and dysgraphia. (22465163)
2012
15
The use of semantic- and phonological-based feature approaches to treat naming deficits in aphasia. (22540360)
2012
16
Living successfully with aphasia: a qualitative meta-analysis of the perspectives of individuals with aphasia, family members, and speech-language pathologists. (22149648)
2012
17
The neural basis of syntactic deficits in primary progressive aphasia. (22546214)
2012
18
Cerebrospinal fluid tau, p-tau 181 and amyloid-I^38/40/42 in frontotemporal dementias and primary progressive aphasias. (21135556)
2011
19
Assessing neuropsychiatric disturbances associated with post-stroke aphasia. (22231346)
2011
20
Aphasia centers: a growing trend in North America. (21968556)
2011
21
Teaching nursing assistant students about aphasia and communication. (21968560)
2011
22
Validation of the language component of the Addenbrooke's Cognitive Examination--Revised (ACE-R) as a screening tool for aphasia in stroke patients. (21923710)
2011
23
Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation. (20479359)
2010
24
Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia. (21159955)
2010
25
Syndromes of nonfluent primary progressive aphasia: a clinical and neurolinguistic analysis. (20713949)
2010
26
Primary progressive aphasia and caregiver issues. (19810201)
2009
27
Abnormal laughter-like vocalisations replacing speech in primary progressive aphasia. (19435636)
2009
28
Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. (17914064)
2008
29
Steroid treatment of primary progressive aphasia. (19001174)
2008
30
Dysgraphia in two forms of conduction aphasia. (15629207)
2005
31
Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia. (16315279)
2005
32
A longitudinal study of sentence comprehension difficulty in primary progressive aphasia. (15834020)
2005
33
Preservation of reasoning in primary progressive aphasia: further differentiation from Alzheimer's disease and the behavioral presentation of frontotemporal dementia. (15512925)
2004
34
Primary progressive aphasia--a language-based dementia. (14561797)
2003
35
Axonal injury within language network in primary progressive aphasia. (12557292)
2003
36
Primary progressive aphasia: PPA and the language network. (12509846)
2003
37
Primary progressive aphasia: a review of the neurobiology of a common presentation of Pick complex. (11831418)
2002
38
The use of reaction time measures to evaluate nonword reading in primary progressive aphasia. (10857687)
2000
39
Primary progressive aphasia presenting as conduction aphasia. (10521554)
1999
40
The neuropsychological signature of primary progressive aphasia. (10534372)
1999
41
Apolipoprotein E genotypes in primary progressive aphasia. (9222169)
1997
42
Nonfluent progressive aphasia and semantic dementia: a comparative neuropsychological study. (9375155)
1996
43
Clinical and pathological characteristics of primary progressive aphasia and frontal dementia. (8841961)
1996
44
Regional cerebral perfusion in Landau-Kleffner syndrome and related childhood aphasias. (1383478)
1992
45
Acquired epileptiform aphasia in children (Landau-Kleffner syndrome). (1918334)
1991
46
Acquired aphasia with convulsive disorder: a pervasive developmental disorder variant. (1700988)
1990
47
Adult follow-up of the acquired aphasia-epilepsy syndrome in childhood. Report of 7 cases. (2476680)
1989
48
Progressive aphasia with right-sided extrapyramidal signs: another manifestation of localised cerebral atrophy. (2468739)
1989
49
The Landau-Kleffner syndrome of acquired epileptic aphasia: unusual clinical outcome, surgical experience, and absence of encephalitis. (2447519)
1988
50
Left medial parietal lobe and receptive language functions: mixed transcortical aphasia after left anterior cerebral artery infarction. (7188794)
1980

Genetic Variations for Aphasia

About this section

Expression for genes affiliated with Aphasia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aphasia

Search GEO for disease gene expression data for Aphasia.

Pathways for genes affiliated with Aphasia

About this section
Sources:
4Cell Signaling Technology
See all sources

Pathways related to Aphasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8LRRK2, TARDBP, MAPT, SNCA, SNCB, APP

Compounds for genes affiliated with Aphasia

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Aphasia according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1tmao4410.5SNCA, MAPT
2thioflavin4410.5MAPT, SNCA, APP
3thioflavin t4410.5APP, SNCA
46-hydroxydopamine4410.4SNCA, APP, RPS27A
5tacrine44 1111.4MAPT, APP
6guanidine hydrochloride4410.4PRNP, SNCA, RPS27A
7thioflavine s4410.4MAPT, SNCA, APP, RPS27A
8silver4410.3MAPT, SNCA, RPS27A
94-hydroxynonenal44 2411.3RPS27A, APP, SNCA, MAPT
10lactacystin4410.3MAPT, SNCA, APP, RPS27A
11formaldehyde44 2411.3RPS27A, APP, PRNP, MAPT
12methionine sulfoxide44 11 2412.3APP, SNCA
13chloroquine44 2 49 28 1114.3RPS27A, APP, MAPT
14formate4410.3RPS27A, APP, SNCA, PRNP, MAPT
15donepezil44 11 2412.2APP, MAPT
16memantine44 28 1112.2MAPT, APP
17sodium dodecylsulfate4410.2RPS27A, APP, SNCA, PRNP, MAPT
18valine4410.2MAPT, PRNP, SNCA, APP, RPS27A
19levodopa44 1111.2LRRK2, SNCA, RPS27A
20dopamine44 28 11 2413.2LRRK2, MAPT, SNCA, APP, RPS27A
21h2o24410.1RPS27A, APP, SNCB, SNCA, PRNP, MAPT
22glutamate4410.1RPS27A, L1CAM, APP, SNCA, PRNP, MAPT
23testosterone44 59 11 2412.7RPS27A, APP, SNCA, MAPT, SLC22A7
24acetylcholine44 49 28 11 2413.7MAPT, SNCA, APP, RPS27A

GO Terms for genes affiliated with Aphasia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:03042610.1MAPT, SNCA, SNCB
2terminal boutonGO:0431959.8SNCA, SNCB, L1CAM

Biological processes related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of locomotionGO:04001210.2SNCA, LRRK2
2axon cargo transportGO:00808810.1APP, MAPT
3response to oxidative stressGO:00697910.1APP, PRNP, LRRK2
4cell deathGO:00821910.1L1CAM, CHMP2B, GRN, TARDBP
5cellular copper ion homeostasisGO:0068789.9APP, PRNP

Molecular functions related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.8LRRK2, TARDBP, PRNP, SNCA, APP, L1CAM

Products for genes affiliated with Aphasia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aphasia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet