MCID: APH002
MIFTS: 49

Aphasia malady

Summaries for Aphasia

Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Aphasia is a disorder caused by damage to the parts of the brain that control language. it can make it hard for you to read, write, and say what you mean to say. it is most common in adults who have had a stroke. brain tumors, infections, injuries, and dementia can also cause it. the type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. there are four main types: expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean receptive aphasia - you hear the voice or see the print, but you can't make sense of the words anomic aphasia - you have trouble using the correct word for objects, places, or events global aphasia - you can't speak, understand speech, read, or write some people recover from aphasia without treatment. most, however, need language therapy as soon as possible. nih: national institute of neurological disorders and stroke

MalaCards: Aphasia is related to primary progressive aphasia and semantic dementia. An important gene associated with Aphasia is L1CAM (L1 cell adhesion molecule), and among its related pathways is Neuroscience. The compounds tmao and thioflavin have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and cortex, and related mouse phenotypes are pigmentation and no phenotypic analysis.

Disease Ontology:8 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.

NINDS:44 Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language. Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Most commonly seen in adults who have suffered a stroke, aphasia can also result from a brain tumor, infection, head injury, or dementia that damages the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue.

Wikipedia:64 Aphasia (/əˈfeɪʒə/, /əˈfeɪziə/ or /eɪˈfeɪziə/; from ancient Greek aphatos meaning... more...

Aliases & Classifications for Aphasia

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS
See all sources

Aliases & Descriptions:

aphasia 8 44 10 45 34 61


External Ids:

Disease Ontology8 DOID:0060046

Related Diseases for Aphasia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Aphasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 372)
idRelated DiseaseScoreTop Affiliating Genes
1primary progressive aphasia31.5MAPT, GRN, RPS27A
2semantic dementia30.7MAPT, GRN, RPS27A
3frontotemporal dementia30.6LRRK2, TARDBP, MAPT, GRN, CHMP2B, SNCA
4progressive supranuclear palsy30.3GRN, MAPT, TARDBP
5alzheimer's disease30.2RPS27A, APP, SNCB, SNCA, PRNP, GRN
6pick's disease30.1RPS27A, APP, SNCA, MAPT, TARDBP
7frontotemporal lobar degeneration with ubiquitin-positive inclusions30.1GRN
8lateral sclerosis30.0SNCA, MAPT
9memory impairment30.0APP, SNCA, PRNP, GRN, MAPT
10amyotrophic lateral sclerosis29.8RPS27A, APP, SNCA, PRNP, CHMP2B, GRN
11neuronal intranuclear inclusion disease29.6RPS27A
12hemorrhage, intracerebral29.6PRNP, APP, RPS27A
13brain disease29.6APP, SNCA, PRNP, MAPT
14parkinson's disease29.6RPS27A, SNCB, SNCA, MAPT, LRRK2
15tauopathy29.6RPS27A, APP, SNCA, GRN, MAPT, LRRK2
16logopenic progressive aphasia10.6
17apraxia10.6
18landau-kleffner syndrome10.5
19agnosia10.4
20alexia10.4
21corticobasal degeneration10.4
22nominal aphasia10.3
23progressive non-fluent aphasia10.3
24n syndrome10.3
25ideomotor apraxia10.1
26visual agnosia10.1
27gerstmann syndrome10.1
28dysgraphia10.1
29stroke, ischemic10.1
30anosognosia10.1
31auditory agnosia10.1
32spastic paraplegia 110.1
33anterior cerebral artery infarction10.0
34amusia10.0
35associative agnosia10.0
36seizure disorder10.0
37neuroblastoma10.0PRNP
38rem sleep behavior disorder10.0SNCA
39hydrocephalus10.0MAPT, L1CAM
40schizophrenia10.0SNCA
41scrapie10.0MAPT, PRNP
42gastrointestinal stromal tumor10.0SMUG1
43lewy body dementia10.0SNCB, SNCA
44lrrk2-related parkinson disease10.0LRRK2
45neuroaxonal dystrophy, infantile10.0RPS27A, APP
46spinocerebellar ataxia type 310.0SNCA, RPS27A
47gerstmann-straussler-scheinker disease10.0PRNP, APP
48parkinson disease type 310.0LRRK2, MAPT, SNCA
49cerebral amyloid angiopathy10.0MAPT, PRNP, APP
50encephalitis10.0LGI1, APP

Graphical network of the top 20 diseases related to Aphasia:



Diseases related to aphasia

Clinical Features for Aphasia

Drugs & Therapeutics for Aphasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aphasia

Drug clinical trials:

Search ClinicalTrials for Aphasia

Search NIH Clinical Center for Aphasia

Search CenterWatch for Aphasia

Genetic Tests for Aphasia

Anatomical Context for Aphasia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Aphasia:

33
Skin, Brain, Cortex, Prefrontal cortex, Parietal lobe, Temporal lobe, Occipital lobe

Animal Models for Aphasia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Aphasia

Sources:
51PubMed
See all sources

Articles related to Aphasia:

(show top 50)    (show all 839)
idTitleAuthorsYear
1
Speech-language pathologists' contribution to the assessment of decision-making capacity in aphasia: A survey of common practices. (24400775)
2014
2
Representation of people with aphasia in randomized controlled trials of acute stroke interventions. (23506193)
2014
3
Prediction of aphasia outcome using diffusion tensor tractography for arcuate fasciculus in stroke. (23042924)
2013
4
'Stroke a Chord': the effect of singing in a community choir on mood and social engagement for people living with aphasia following a stroke. (23867418)
2013
5
Cognate Effects and Executive Control in a Patient With Differential Bilingual Aphasia. (23557193)
2013
6
Initial neuropsychological profile of a series of 20 patients with logopenic variant of primary progressive aphasia. (23676308)
2013
7
Lexical priming in Alzheimer's disease and aphasia. (23635864)
2013
8
Semantic control and modality: an input processing deficit in aphasia leading to deregulated semantic cognition in a single modality. (23851292)
2013
9
Treatment for apraxia of speech in nonfluent variant primary progressive aphasia. (22713405)
2013
10
From primary progressive aphasia to corticobasal syndrome: two clinical and rCBF functional reports. (22512772)
2013
11
Excitatory Deep Transcranial Magnetic Stimulation With H-Coil Over the Right Homologous Broca's Region Improves Naming in Chronic Post-stroke Aphasia. (24243918)
2013
12
Decreased striatal dopamine transporter uptake in the non-fluent/agrammatic variant of primary progressive aphasia. (23679075)
2013
13
Lexical learning in mild aphasia: gesture benefit depends on patholinguistic profile and lesion pattern. (24001598)
2013
14
Supporting autonomy for people with aphasia: use of the Life Interests and Values (LIV) Cards. (23340068)
2013
15
What Role Does the Anterior Temporal Lobe Play in Sentence-level Processing? Neural Correlates of Syntactic Processing in Semantic Variant Primary Progressive Aphasia. (24345172)
2013
16
Verb Transitivity Bias Affects On-line Sentence Reading in People with Aphasia. (23554543)
2013
17
Phonological therapy in jargon aphasia: effects on naming and neologisms. (24033655)
2013
18
Examining the value of lexical retrieval treatment in primary progressive aphasia: two positive cases. (23871425)
2013
19
Measuring lexical diversity in narrative discourse of people with aphasia. (23695912)
2013
20
FOXP2, APOE, and PRNP: new modulators in primary progressive aphasia. (22129783)
2012
21
Epidural electrical stimulation to improve chronic poststroke aphasia: a 5-year follow-up. (22037142)
2012
22
Short-term memory treatment: patterns of learning and generalisation to sentence comprehension in a person with aphasia. (22300398)
2012
23
Evaluating the effectiveness of intervention in long-term aphasia post-stroke: the experience from CHANT (Communication Hub for Aphasia in North Tyneside). (22788226)
2012
24
Psychosocial well-being in persons with aphasia participating in a nursing intervention after stroke. (22888417)
2012
25
Speech-like and non-speech lip kinematics and coordination in aphasia. (23121525)
2012
26
Behavioral neurology in language and aphasia: from basic studies to clinical applications. (23314975)
2012
27
Transcranial magnetic stimulation and aphasia rehabilitation. (22202188)
2012
28
Decision making cognition in primary progressive aphasia. (22207422)
2012
29
Teaching NeuroImages: primary progressive aphasia: PET demonstration. (21670429)
2011
30
Frontal lobe damage impairs process and content in semantic memory: evidence from category-specific effects in progressive non-fluent aphasia. (20576258)
2011
31
The role of Broca's area in speech perception: evidence from aphasia revisited. (21920592)
2011
32
Headache and aphasia in a young woman with protein S deficiency and nephrotic syndrome. (22649897)
2011
33
Frontotemporal dementia and primary progressive aphasia: an update. (20717853)
2010
34
Galantamine in frontotemporal dementia and primary progressive aphasia. (18196898)
2008
35
Primary progressive aphasia: relationship between gender and severity of language impairment. (17356343)
2007
36
Transcortical sensory aphasia in a child with subacute sclerosing panencephalitis. (17615663)
2007
37
Organizing a Series of Education and Support Conferences for Caregivers of Individuals With Frontotemporal Dementia and Primary Progressive Aphasia. (20596301)
2006
38
Category and letter fluency in semantic dementia, primary progressive aphasia, and Alzheimer's disease. (16325251)
2006
39
Distinct neurolinguistic symptom clusters in Alzheimer's-type dementia and primary progressive aphasia. (12030517)
2002
40
Sign language in childhood epileptic aphasia (Landau-Kleffner syndrome). (11730147)
2001
41
Associative agnosia and optic aphasia: qualitative or quantitative difference? (9088725)
1997
42
Corticobasal degeneration with primary progressive aphasia and accentuated cortical lesion in superior temporal gyrus: case report and review. (8922068)
1996
43
Varieties of progressive non-fluent aphasia. (8624092)
1996
44
Ideomotor apraxia without aphasia and aphasia without apraxia: the anatomical support for a double dissociation. (7681472)
1993
45
Autotopagnosia. Occurrence in a patient without nominal aphasia and with an intact ability to point to parts of animals and objects. (4075073)
1985
46
Age of onset and outcome in 'acquired aphasia with convulsive disorder' (Landau-Kleffner syndrome). (2419188)
1985
47
Incomplete Kluver-Bucy syndrome and fluent aphasia. (6518356)
1984
48
Conduction aphasia, syntactic alexia, and the anatomy of syntactic comprehension. (7073544)
1982
49
ANOSOGNOSIA AND APHASIA. (14272209)
1963
50
Nominal aphasia due to extradural temporal lobe abscess. (13043172)
1953

Genetic Variations for Aphasia

Expression for genes affiliated with Aphasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aphasia

Search GEO for disease gene expression data for Aphasia.

Pathways for genes affiliated with Aphasia

Sources:
4Cell Signaling Technology
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Pathways related to Aphasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8LRRK2, TARDBP, MAPT, SNCA, SNCB, APP

Compounds for genes affiliated with Aphasia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Aphasia according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1tmao4510.5SNCA, MAPT
2thioflavin4510.5MAPT, SNCA, APP
3thioflavin t4510.5APP, SNCA
46-hydroxydopamine4510.4SNCA, APP, RPS27A
5tacrine45 1111.4MAPT, APP
6guanidine hydrochloride4510.4PRNP, SNCA, RPS27A
7thioflavine s4510.4MAPT, SNCA, APP, RPS27A
8silver4510.3MAPT, SNCA, RPS27A
94-hydroxynonenal45 2411.3RPS27A, APP, SNCA, MAPT
10lactacystin4510.3MAPT, SNCA, APP, RPS27A
11formaldehyde45 2411.3RPS27A, APP, PRNP, MAPT
12methionine sulfoxide45 11 2412.3APP, SNCA
13chloroquine45 2 50 29 1114.3RPS27A, APP, MAPT
14formate4510.3RPS27A, APP, SNCA, PRNP, MAPT
15donepezil45 11 2412.2APP, MAPT
16memantine45 29 1112.2MAPT, APP
17sodium dodecylsulfate4510.2RPS27A, APP, SNCA, PRNP, MAPT
18valine4510.2MAPT, PRNP, SNCA, APP, RPS27A
19levodopa45 1111.2LRRK2, SNCA, RPS27A
20dopamine45 29 11 2413.2LRRK2, MAPT, SNCA, APP, RPS27A
21h2o24510.1RPS27A, APP, SNCB, SNCA, PRNP, MAPT
22glutamate4510.1RPS27A, L1CAM, APP, SNCA, PRNP, MAPT
23testosterone45 60 11 2412.7RPS27A, APP, SNCA, MAPT, SLC22A7
24acetylcholine45 50 29 11 2413.7MAPT, SNCA, APP, RPS27A

GO Terms for genes affiliated with Aphasia

Sources:
16Gene Ontology
See all sources

Cellular components related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:03042610.1MAPT, SNCA, SNCB
2terminal boutonGO:0431959.8SNCA, SNCB, L1CAM

Biological processes related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of locomotionGO:04001210.2LRRK2, SNCA
2axon cargo transportGO:00808810.1APP, MAPT
3response to oxidative stressGO:00697910.1LRRK2, PRNP, APP
4cell deathGO:00821910.1TARDBP, GRN, CHMP2B, L1CAM
5cellular copper ion homeostasisGO:0068789.9PRNP, APP

Molecular functions related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.8LRRK2, TARDBP, PRNP, SNCA, APP, L1CAM

Products for genes affiliated with Aphasia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aphasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet