Aliases & Classifications for Aphasia

Aliases & Descriptions for Aphasia:

Name: Aphasia 12 51 29 52 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060046

Summaries for Aphasia

MedlinePlus : 41 aphasia is a disorder caused by damage to the parts of the brain that control language. it can make it hard for you to read, write, and say what you mean to say. it is most common in adults who have had a stroke. brain tumors, infections, injuries, and dementia can also cause it. the type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. there are four main types: expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean receptive aphasia - you hear the voice or see the print, but you can't make sense of the words anomic aphasia - you have trouble using the correct word for objects, places, or events global aphasia - you can't speak, understand speech, read, or write some people recover from aphasia without treatment. most, however, need language therapy as soon as possible. nih: national institute of neurological disorders and stroke

MalaCards based summary : Aphasia is related to thrombosis and autotopagnosia, and has symptoms including back pain, cachexia and cyanosis. An important gene associated with Aphasia is L1CAM (L1 Cell Adhesion Molecule), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease Pathway. The drugs Dopamine and Memantine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related phenotypes are behavior/neurological and cellular

NINDS : 51 Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language production or processing.  It may occur suddenly or progressively, depending on the type and location of brain tissue involved.  Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Although it is primarily seen in individuals who have suffered a stroke, aphasia can also result from a brain tumor, infection, inflammation, head injury, or dementia that affect language-associated regions of the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue.

Disease Ontology : 12 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.

Wikipedia : 71 Aphasia is an inability to comprehend and formulate language because of damage to specific brain... more...

Related Diseases for Aphasia

Diseases related to Aphasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
id Related Disease Score Top Affiliating Genes
1 thrombosis 29.3 LRRK2 SNCA
2 autotopagnosia 29.2 APOE C9orf72 FOXP2 GRN MAPT
3 epilepsy-aphasia spectrum 12.3
4 logopenic progressive aphasia 12.3
5 nominal aphasia 12.2
6 progressive non-fluent aphasia 12.2
7 landau-kleffner syndrome 11.9
8 epilepsy, focal, with speech disorder and with or without mental retardation 11.8
9 frontotemporal lobar degeneration with ubiquitin-positive inclusions 11.7
10 progressive supranuclear palsy-progressive non-fluent aphasia syndrome 11.7
11 intellectual disability-expressive aphasia-facial dysmorphism syndrome 11.7
12 semantic dementia 11.7
13 masa syndrome 11.6
14 gerstmann syndrome 11.1
15 agraphia 11.0
16 marchiafava bignami disease 11.0
17 moyamoya disease 11.0
18 dementia, frontotemporal 11.0
19 pick disease 11.0
20 autosomal dominant partial epilepsy with auditory features 10.8
21 spastic paraplegia 1 10.7
22 progressive multifocal leukoencephalopathy 10.7
23 sudanophilic cerebral sclerosis 10.7
24 dementia, familial, nonspecific 10.7
25 transient cerebral ischemia 10.7
26 mini stroke 10.7
27 supranuclear palsy, progressive 10.7
28 myelinoclastic diffuse sclerosis 10.7
29 handl syndrome 10.7
30 dementia 10.4
31 apraxia 10.4
32 protein r deficiency 10.3 GRN MAPT
33 keratosis palmoplantaris striata 10.3 APOE MAPT
34 mcleod neuroacanthocytosis syndrome 10.3 MAPT PSEN1
35 pancreatitis 10.3 GRN PSEN1
36 homocystinuria caused by cystathionine beta-synthase deficiency 10.2 APOE PRNP
37 femoral neuropathy 10.2 GRN MAPT
38 scrotum basal cell carcinoma 10.2 MAPT PRNP
39 gata1-related thrombocytopenia 10.2 GRN MAPT PSEN1
40 hereditary paraganglioma-pheochromocytoma syndromes 10.2 GRN MAPT PSEN1
41 fancf-related fanconi anemia 10.2 APOE PRNP
42 ichthyosis lamellar 2 10.2 APOE L1CAM MAPT
43 encephalitozoonosis 10.2 APOE GRN PSEN1
44 meckel syndrome 10 10.2 APOE MAPT PSEN1
45 agnosia 10.2
46 amino acid metabolic disorder 10.1 FOXP2 GRIN2A GRN
47 prion disease with protracted course 10.1 APOE MAPT PRNP
48 alexia 10.1
49 hyperglycemia 10.1 GRN PSEN1
50 polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract 10.1 APOE PRNP PSEN1

Graphical network of the top 20 diseases related to Aphasia:



Diseases related to Aphasia

Symptoms & Phenotypes for Aphasia

UMLS symptoms related to Aphasia:


back pain, cachexia, cyanosis, dyspnea, edema, fever, headache, icterus, other symptoms involving head and neck, pain, sciatica, seizures, signs and symptoms, signs and symptoms, digestive, syncope, tremor, vertigo, chronic pain, swelling, mass, or lump in head and neck, aprosodia, aphasic, sore throat, scanning speech, symptoms involving head and neck, other and unspecified speech disturbances, other symbolic dysfunction, vertigo/dizziness, hot flushes, sleeplessness, other speech disturbances, central nervous system signs and symptoms

MGI Mouse Phenotypes related to Aphasia:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.31 PSEN1 SLC20A2 SNCA TARDBP APOE C9orf72
2 cellular MP:0005384 10.22 MAPT PRNP PSEN1 SNCA TARDBP APOE
3 homeostasis/metabolism MP:0005376 10.18 APOE C9orf72 GRN LRRK2 MAPT PRNP
4 growth/size/body region MP:0005378 10.16 APOE C9orf72 L1CAM MAPT PRNP PSEN1
5 immune system MP:0005387 10.16 APOE C9orf72 GRN LRRK2 MAPT PRNP
6 hematopoietic system MP:0005397 10.15 PRNP PSEN1 SLC20A2 TARDBP APOE C9orf72
7 nervous system MP:0003631 10.15 APOE C9orf72 GRIN2A GRN L1CAM LRRK2
8 mortality/aging MP:0010768 10.14 APOE C9orf72 GRN L1CAM LRRK2 MAPT
9 integument MP:0010771 10.03 APOE GRIN2A L1CAM LRRK2 MAPT PRNP
10 no phenotypic analysis MP:0003012 9.97 APOE C9orf72 GRN L1CAM LRRK2 MAPT
11 skeleton MP:0005390 9.81 PRNP PSEN1 SLC20A2 SNCA TARDBP APOE
12 pigmentation MP:0001186 9.56 APOE GRN L1CAM LRRK2
13 vision/eye MP:0005391 9.17 APOE GRN L1CAM MAPT PRNP PSEN1
14 taste/olfaction MP:0005394 9.13 SNCA APOE MAPT

Drugs & Therapeutics for Aphasia

Drugs for Aphasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 159)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-61-6, 62-31-7 681
2
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
3
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
4
Donepezil Approved Phase 4 120014-06-4 3152
5 Piracetam Approved Phase 4,Phase 1 7491-74-9
6
Levodopa Approved Phase 4,Phase 2,Phase 3 59-92-7 6047
7
Citalopram Approved Phase 4 59729-33-8 2771
8
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
9
Amantadine Approved Phase 4,Phase 2,Phase 3 768-94-5 2130
10 tannic acid Approved, Nutraceutical Phase 4,Phase 3
11 Antiparkinson Agents Phase 4,Phase 2,Phase 3
12 Dopamine Agents Phase 4,Phase 2,Phase 3,Phase 1
13 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
14 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
15 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
16 Cholinergic Agents Phase 4,Phase 2
17 Cholinesterase Inhibitors Phase 4,Phase 2
18 Nootropic Agents Phase 4,Phase 2,Phase 1
19 Protective Agents Phase 4,Phase 1,Phase 2
20 Autonomic Agents Phase 4,Phase 2
21 Dopamine agonists Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Antidepressive Agents Phase 4,Phase 2
24 Antidepressive Agents, Second-Generation Phase 4
25 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
26 Psychotropic Drugs Phase 4,Phase 2
27
Serotonin Phase 4 50-67-9 5202
28 Serotonin Agents Phase 4
29 Serotonin Uptake Inhibitors Phase 4
30 Analgesics Phase 4,Phase 2,Phase 3
31 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
32 Anti-Inflammatory Agents Phase 4
33 Anti-Inflammatory Agents, Non-Steroidal Phase 4
34 Antipyretics Phase 4
35 Antirheumatic Agents Phase 4,Phase 2,Phase 3
36 Cyclooxygenase Inhibitors Phase 4
37 Fibrinolytic Agents Phase 4
38 Platelet Aggregation Inhibitors Phase 4
39
Corticosterone Phase 4,Phase 1,Early Phase 1 50-22-6 5753
40 Fluorodeoxyglucose F18 Phase 4,Phase 2,Phase 1
41 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
42 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1
43 Pharmaceutical Solutions Phase 4
44
Carbidopa Approved Phase 2, Phase 3 28860-95-9 34359 38101
45
Miglustat Approved Phase 3,Phase 1 72599-27-0 51634
46
Busulfan Approved, Investigational Phase 2, Phase 3 55-98-1 2478
47
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
48
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
49
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
50
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700

Interventional clinical trials:

(show top 50) (show all 253)
id Name Status NCT ID Phase
1 Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial Unknown status NCT00196703 Phase 4
2 Effect of Memantine Oral Pump on Language in Patients With Probable Alzheimer's Disease Unknown status NCT01849042 Phase 4
3 Memantine and Intensive Speech-Language Therapy in Aphasia Completed NCT00640198 Phase 4
4 Donepezil in Chronic Poststroke Aphasia: a Randomized Controlled Trial Completed NCT00196690 Phase 4
5 Dopaminergic Enhancement of Learning and Memory in Aphasia Completed NCT00102869 Phase 4
6 Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia Completed NCT00376051 Phase 4
7 Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia Completed NCT00545974 Phase 4
8 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4
9 Imaging of Brain Amyloid Plaques in the Aging Population Enrolling by invitation NCT00950430 Phase 4
10 A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke Terminated NCT01883011 Phase 4
11 Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD) Terminated NCT00127114 Phase 4
12 Improvement of Language Disturbances After Stroke by Intensive Training and Electrical Brain Stimulation Unknown status NCT00822068 Phase 2, Phase 3
13 Augmenting Language Therapy for Aphasia: Levodopa Completed NCT01429077 Phase 2, Phase 3
14 Action of Amantadine on Post-Stroke Aphasic Patients Completed NCT00821691 Phase 2, Phase 3
15 Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD) Completed NCT01626378 Phase 3
16 Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia Completed NCT00594737 Phase 3
17 Application of Miglustat in Patients With Niemann-Pick Type C Completed NCT01760564 Phase 3
18 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3
19 Oral HYCAMTIN Plus Whole Brain Radiation Therapy In Treatment Of Brain Metastases Resulting From Non-Small Lung Cancer Completed NCT00390806 Phase 3
20 Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients Recruiting NCT02241213 Phase 3
21 Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia Recruiting NCT00903266 Phase 3
22 Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window Recruiting NCT00826059 Phase 3
23 Study of VTS-270 (2-hydroxypropyl-β-cyclodextrin) to Treat Niemann-Pick Type C1 (NPC1) Disease Recruiting NCT02534844 Phase 2, Phase 3
24 Non-vitamin K Antagonist Oral Anticoagulants in Patients With Atrial High Rate Episodes Recruiting NCT02618577 Phase 3
25 Arimoclomol Prospective Study in Patients Diagnosed With NiemannPick Disease Type C Active, not recruiting NCT02612129 Phase 2, Phase 3
26 Open-Label Study of TRx0237 in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD) Enrolling by invitation NCT02245568 Phase 3
27 Non-invasive Repetitive Paraorbital Alternating Current Stimulation Therapy for Aphasia Terminated NCT01277575 Phase 3
28 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation (CATS) Unknown status NCT01924702 Phase 2
29 Chronic Aphasia - Improved by Intensive Training and Electrical Brain Stimulation Unknown status NCT01221779 Phase 2
30 Study to Assess the Safety, Tolerability, and Pharmacodynamic (PD) Effects of FRM-0334 in Subjects With Prodromal to Moderate Frontotemporal Dementia With Granulin Mutation Unknown status NCT02149160 Phase 2
31 Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia Completed NCT01300624 Phase 2
32 Using Transcranial Direct Current Stimulation (tDCS) to Improve Post-Stroke Aphasia Completed NCT01709383 Phase 2
33 Treating Intention In Aphasia: Neuroplastic Substrates Completed NCT00567242 Phase 1, Phase 2
34 AERs in Aphasia: Severity and Improvement Completed NCT00013442 Phase 2
35 Phonomotor Treatment of Word Retrieval Deficits in Individuals With Aphasia Completed NCT01163461 Phase 2
36 Psychosocial Wellbeing Following Stroke Completed NCT01912014 Phase 1, Phase 2
37 Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease Completed NCT00814697 Phase 2
38 Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes Completed NCT00827268 Phase 1, Phase 2
39 A Pilot Study to Explore the Safety and Tolerability of Galantamine HBr in the Treatment of Pick Complex/Frontotemporal Dementia Completed NCT00416169 Phase 2
40 Posturing Effects on Perception of Time and Perceptions of the Provider-Patient Interaction in the Emergency Department Completed NCT00170105 Phase 2
41 Efficacy and Tolerability of Memantine in Frontotemporal Dementia (FTD) Patients Completed NCT00200538 Phase 2
42 Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls. Completed NCT01890343 Phase 2
43 Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study Completed NCT00810095 Phase 2
44 Phase 1/2 Study of Vorinostat Therapy in Niemann-Pick Disease, Type C1 Completed NCT02124083 Phase 1, Phase 2
45 Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine Completed NCT00975689 Phase 1, Phase 2
46 Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Completed NCT00730314 Phase 1, Phase 2
47 Evaluating Anodal tDCS Preceding Aphasia Therapy Recruiting NCT02249819 Phase 1, Phase 2
48 Dosage and Predictors of Naming Treatment Response in Aphasia Recruiting NCT02005016 Phase 1, Phase 2
49 Targeted Electrotherapy for Aphasia Stroke Rehabilitation (TEASER) - Phase II Multi-Center Study Recruiting NCT02540109 Phase 2
50 Brain Stimulation and Aphasia Treatment Recruiting NCT01686373 Phase 2

Search NIH Clinical Center for Aphasia

Genetic Tests for Aphasia

Genetic tests related to Aphasia:

id Genetic test Affiliating Genes
1 Aphasia 29

Anatomical Context for Aphasia

MalaCards organs/tissues related to Aphasia:

39
Brain, Testes, Cortex, Temporal Lobe, Tongue, Parietal Lobe, Prefrontal Cortex

Publications for Aphasia

Articles related to Aphasia:

(show top 50) (show all 1012)
id Title Authors Year
1
Naming unique entities in the semantic variant of primary progressive aphasia and Alzheimer's disease: Towards a better understanding of the semantic impairment. ( 27939367 )
2017
2
Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia. ( 28515265 )
2017
3
Functional activation independently contributes to naming ability and relates to lesion site in post-stroke aphasia. ( 28083891 )
2017
4
Sporadic Creutzfeldt-Jakob disease presenting with isolated progressive non-fluent aphasia in a young woman. ( 28444466 )
2017
5
Combined aphasia and apraxia of speech treatment (CAAST): Systematic replications in the development of a novel treatment. ( 28084854 )
2017
6
Cholinergic depletion and basal forebrain volume in primary progressive aphasia. ( 28018854 )
2017
7
Grey Matter Density Predicts the Improvement of Naming Abilities After tDCS Intervention in Agrammatic Variant of Primary Progressive Aphasia. ( 27194245 )
2016
8
Diffuse leukoencephalopathy with spheroids presenting as primary progressive aphasia. ( 27163664 )
2016
9
Non Fluent Variant of Primary Progressive Aphasia Due to the Novel GRN g.9543delA(IVS3-2delA) Mutation. ( 27567822 )
2016
10
Recipient participation in conversations involving participants with fluent or non-fluent aphasia. ( 27645117 )
2016
11
Psychometric properties of the Behavioural Outcomes of Anxiety questionnaire in stroke patients with aphasia. ( 27121863 )
2016
12
The Role of Single-Subject Brain Metabolic Patterns in the Early Differential Diagnosis of Primary Progressive Aphasias and in Prediction of Progression to Dementia. ( 27662315 )
2016
13
WHEN WORDS FAIL. A SUMMARY OF APHASIA: INCORPORATING BACKGROUND MEMOIR ACCOUNTS. ( 27530025 )
2016
14
How do speech-and-language therapists address the psychosocial well-being of people with aphasia? Results of a UK online survey. ( 27593505 )
2016
15
Beyond aphasia: Altered EEG connectivity in Broca's patients during working memory task. ( 27631161 )
2016
16
Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia. ( 27214154 )
2016
17
Teaching NeuroImages: Aphasia after infarction of the left pulvinar nucleus. ( 27550899 )
2016
18
Clinical Reasoning: An 82-year-old woman with dissociated aphasia followed by amnesia. ( 27572435 )
2016
19
Aphasia in a patient with acute hepatic encephalopathy associated with multifocal cortical brain lesions. ( 27157523 )
2016
20
Deep Dyslexia in Chinese Primary Progressive Aphasia of Semantic Variant. ( 27093385 )
2016
21
The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study. ( 27965899 )
2016
22
Aphasia rehabilitation during adolescence: a case report. ( 27538892 )
2016
23
Integrative intervention: a new perspective and brief review in aphasia. ( 27569048 )
2016
24
Regional I^-amyloid burden does not correlate with cognitive or language deficits in Alzheimer's disease presenting as aphasia. ( 26101072 )
2016
25
Improved word comprehension in Global aphasia using a modified semantic feature analysis treatment. ( 27548515 )
2016
26
Acquired dyslexia in Serbian speakers with Broca's and Wernicke's aphasia. ( 27135368 )
2016
27
Benefits and Limitations of Computer Gesture Therapy for the Rehabilitation of Severe Aphasia. ( 27965554 )
2016
28
Aphasia and literacy-the insider's perspective. ( 28039933 )
2016
29
A Dextral Primary Progressive Aphasia Patient with Right Dominant Hypometabolism and Tau Accumulation and Left Dominant Amyloid Accumulation. ( 27194988 )
2016
30
Increased inter-hemispheric resting-state functional connectivity in acute lacunar stroke patients with aphasia. ( 27942764 )
2016
31
Neuroscientific Implications in Assessment and Intervention for Aphasia. ( 27160401 )
2016
32
Assessment Fidelity in Aphasia Research. ( 27997953 )
2016
33
Comparing the production of complex sentences in Persian patients with post-stroke aphasia and non-damaged people with normal speaking. ( 27141274 )
2016
34
Neuropathologic Associations of Learning and Memory in Primary Progressive Aphasia. ( 27183206 )
2016
35
Pathological Diagnosis During Life in Patients With Primary Progressive Aphasia: Seeking the Holy Grail. ( 27182808 )
2016
36
Enhanced patient involvement in Swedish aphasia intervention. ( 27624643 )
2016
37
Brain Perfusion in Corticobasal Syndrome with Progressive Aphasia. ( 27195001 )
2016
38
Cortical blindness along with motor aphasia: An unusual presentation of fat embolism syndrome. ( 28018064 )
2016
39
Subacute progressive aphasia: a rare presentation of Creutzfeldt-Jakob disease. ( 26872666 )
2016
40
Looking for a Location: Dissociated Effects of Event-Related Plausibility and Verb-Argument Information on Predictive Processing in Aphasia. ( 27997951 )
2016
41
The neural correlates of auditory and visuospatial span in logopenic progressive aphasia and Alzheimer's disease. ( 27474916 )
2016
42
Use of tDCS in Aphasia Rehabilitation: A Systematic Review of the Behavioral Interventions Implemented With Noninvasive Brain Stimulation for Language Recovery. ( 27997958 )
2016
43
Clinical study of acupuncture treatment on motor aphasia after stroke. ( 27177100 )
2016
44
Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. ( 27111692 )
2016
45
Special Section: Language System Plasticity in Aphasia; Guest Editor: Roy Hamilton. ( 27567761 )
2016
46
Script Templates: A Practical Approach to Script Training in Aphasia. ( 27594730 )
2016
47
Fields or flows? A comparative metaanalysis of transcranial magnetic and direct current stimulation to treat post-stroke aphasia. ( 27163249 )
2016
48
The canonical semantic network supports residual language function in chronic post-stroke aphasia. ( 27981674 )
2016
49
Effect of electroacupunctureA in patients with post-stroke motor aphasia : Neurolinguistic and neuroimaging characteristics. ( 27590260 )
2016
50
Using principal component analysis to capture individual differences within a unified neuropsychological model of chronic post-stroke aphasia: Revealing the unique neural correlates of speech fluency, phonology and semantics. ( 27216359 )
2016

Variations for Aphasia

Expression for Aphasia

Search GEO for disease gene expression data for Aphasia.

Pathways for Aphasia

Pathways related to Aphasia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.74 APOE GRIN2A LRRK2 MAPT PRNP PSEN1
2 10.79 APOE MAPT PSEN1
3 10.62 GRIN2A MAPT

GO Terms for Aphasia

Cellular components related to Aphasia according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.97 APOE GRIN2A GRN LRRK2 PRNP PSEN1
2 cell junction GO:0030054 9.88 GRIN2A LRRK2 PSEN1 SNCA SRPX2
3 synapse GO:0045202 9.84 GRIN2A LRRK2 SNCA SRPX2
4 cell surface GO:0009986 9.8 GRIN2A L1CAM PRNP PSEN1 SRPX2
5 lysosome GO:0005764 9.76 C9orf72 GRN LRRK2 SNCA
6 axon GO:0030424 9.72 L1CAM LRRK2 MAPT PSEN1 SNCA
7 dendrite GO:0030425 9.63 APOE L1CAM LRRK2 MAPT PRNP PSEN1
8 synaptic vesicle GO:0008021 9.61 GRIN2A LRRK2 SNCA
9 postsynapse GO:0098794 9.54 LRRK2 PRNP SNCA
10 nuclear outer membrane GO:0005640 9.51 PSEN1 SNCA
11 inclusion body GO:0016234 9.43 LRRK2 PRNP SNCA
12 neuronal cell body GO:0043025 9.43 APOE L1CAM LRRK2 MAPT PSEN1 SNCA
13 growth cone GO:0030426 9.02 L1CAM LRRK2 MAPT PSEN1 SNCA
14 extracellular space GO:0005615 10 APOE C9orf72 GRN LRRK2 SNCA SRPX2

Biological processes related to Aphasia according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.82 C9orf72 LRRK2 PSEN1
2 negative regulation of neuron apoptotic process GO:0043524 9.8 APOE PSEN1 SNCA
3 positive regulation of neuron death GO:1901216 9.65 MAPT PRNP
4 excitatory postsynaptic potential GO:0060079 9.65 GRIN2A LRRK2 SNCA
5 positive regulation of dendritic spine development GO:0060999 9.64 APOE PSEN1
6 regulation of canonical Wnt signaling pathway GO:0060828 9.63 LRRK2 PSEN1
7 regulation of synaptic transmission, glutamatergic GO:0051966 9.63 LRRK2 PSEN1
8 regulation of neuron death GO:1901214 9.62 LRRK2 SNCA
9 regulation of neuronal synaptic plasticity GO:0048168 9.61 APOE SNCA
10 positive regulation of endocytosis GO:0045807 9.61 APOE SNCA
11 memory GO:0007613 9.61 GRIN2A MAPT PSEN1
12 regulation of phosphorylation GO:0042325 9.6 PSEN1 SRPX2
13 positive regulation of receptor recycling GO:0001921 9.59 PSEN1 SNCA
14 microglial cell activation GO:0001774 9.58 MAPT SNCA
15 dopamine metabolic process GO:0042417 9.58 GRIN2A SNCA
16 regulation of autophagy GO:0010506 9.58 C9orf72 LRRK2 MAPT
17 supramolecular fiber organization GO:0097435 9.57 MAPT SNCA
18 cellular response to copper ion GO:0071280 9.56 PRNP SNCA
19 negative regulation of protein processing GO:0010955 9.55 LRRK2 PRNP
20 locomotion GO:0040011 9.54 GRIN2A PSEN1
21 negative regulation of neuron death GO:1901215 9.54 APOE LRRK2 SNCA
22 amyloid precursor protein metabolic process GO:0042982 9.52 APOE PSEN1
23 intracellular distribution of mitochondria GO:0048312 9.51 LRRK2 MAPT
24 learning or memory GO:0007611 9.5 GRIN2A PRNP PSEN1
25 regulation of locomotion GO:0040012 9.49 LRRK2 SNCA
26 regulation of mitochondrial fission GO:0090140 9.46 LRRK2 MAPT
27 synapse organization GO:0050808 9.33 L1CAM MAPT SNCA
28 negative regulation of long-term synaptic potentiation GO:1900272 9.26 APOE PRNP
29 response to oxidative stress GO:0006979 9.26 APOE LRRK2 PRNP PSEN1
30 negative regulation of protein phosphorylation GO:0001933 9.02 LRRK2 PRNP PSEN1 SNCA TARDBP

Molecular functions related to Aphasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 microtubule binding GO:0008017 9.62 LRRK2 MAPT PRNP SNCA
2 tau protein binding GO:0048156 9.37 APOE SNCA
3 lipoprotein particle binding GO:0071813 9.26 APOE MAPT
4 identical protein binding GO:0042802 9.17 APOE LRRK2 MAPT PRNP SNCA SRPX2
5 cuprous ion binding GO:1903136 9.16 PRNP SNCA
6 tubulin binding GO:0015631 9.13 LRRK2 MAPT PRNP
7 protein binding GO:0005515 10.22 APOE C9orf72 FOXP2 GRIN2A GRN L1CAM

Sources for Aphasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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