MCID: APH002
MIFTS: 49

Aphasia malady

Summaries for Aphasia

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Aphasia is a disorder caused by damage to the parts of the brain that control language. it can make it hard for you to read, write, and say what you mean to say. it is most common in adults who have had a stroke. brain tumors, infections, injuries, and dementia can also cause it. the type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. there are four main types: expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean receptive aphasia - you hear the voice or see the print, but you can't make sense of the words anomic aphasia - you have trouble using the correct word for objects, places, or events global aphasia - you can't speak, understand speech, read, or write some people recover from aphasia without treatment. most, however, need language therapy as soon as possible. nih: national institute of neurological disorders and stroke

MalaCards: Aphasia is related to dementia and frontotemporal dementia. An important gene associated with Aphasia is L1CAM (L1 cell adhesion molecule), and among its related pathways is Neuroscience. The compounds tmao and thioflavin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are pigmentation and no phenotypic analysis.

Disease Ontology:8 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.

NINDS:43 Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language. Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Most commonly seen in adults who have suffered a stroke, aphasia can also result from a brain tumor, infection, head injury, or dementia that damages the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue.

Wikipedia:63 Aphasia (/əˈfeɪʒə/, /əˈfeɪziə/ or /eɪˈfeɪziə/), from ancient Greek ἀφασία... more...

Aliases & Classifications for Aphasia

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Sources:
8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS
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Aliases & Descriptions:

aphasia 8 43 10 44 33 60


External Ids:

Disease Ontology8 DOID:0060046

Related Diseases for Aphasia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Primary Progressive Aphasia family:

aphasia

Diseases related to Aphasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 381)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.9RPS27A, APP, SNCB, SNCA, PRNP, GRN
2frontotemporal dementia30.6LRRK2, TARDBP, MAPT, GRN, CHMP2B, SNCA
3alzheimer's disease30.5RPS27A, APP, SNCB, SNCA, PRNP, GRN
4primary progressive aphasia30.5MAPT, GRN, RPS27A
5progressive supranuclear palsy30.3GRN, MAPT, TARDBP
6pick's disease30.2RPS27A, APP, SNCA, MAPT, TARDBP
7frontotemporal lobar degeneration with ubiquitin-positive inclusions30.0GRN
8semantic dementia30.0MAPT, GRN, RPS27A
9encephalitis30.0LGI1, APP
10lateral sclerosis29.9SNCA, MAPT
11tauopathy29.8RPS27A, APP, SNCA, GRN, MAPT, LRRK2
12amyotrophic lateral sclerosis29.8RPS27A, APP, SNCA, PRNP, CHMP2B, GRN
13neuronal intranuclear inclusion disease29.6RPS27A
14lewy body dementia29.6SNCB, SNCA
15brain disease29.6APP, SNCA, PRNP, MAPT
16motor neuron disease29.6RPS27A, SNCA, GRN, MAPT, TARDBP
17parkinson's disease29.6RPS27A, SNCB, SNCA, MAPT, LRRK2
18apraxia10.6
19landau-kleffner syndrome10.5
20agnosia10.4
21alexia10.4
22logopenic progressive aphasia10.4
23cerebritis10.3
24nominal aphasia10.3
25progressive non-fluent aphasia10.2
26ideomotor apraxia10.1
27epilepsy syndrome10.1
28visual agnosia10.1
29gerstmann syndrome10.1
30dysgraphia10.1
31stroke, ischemic10.0
32anosognosia10.0
33auditory agnosia10.0
34spastic paraplegia 110.0
35neuroblastoma10.0PRNP
36rem sleep behavior disorder10.0SNCA
37hydrocephalus10.0MAPT, L1CAM
38schizophrenia10.0SNCA
39scrapie10.0MAPT, PRNP
40gastrointestinal stromal tumor10.0SMUG1
41lrrk2-related parkinson disease10.0LRRK2
42neuroaxonal dystrophy, infantile10.0RPS27A, APP
43spinocerebellar ataxia type 310.0SNCA, RPS27A
44gerstmann-straussler-scheinker disease10.0PRNP, APP
45parkinson disease type 310.0LRRK2, MAPT, SNCA
46cerebral amyloid angiopathy10.0MAPT, PRNP, APP
47down syndrome10.0MAPT, SNCA, APP
48niemann-pick disease10.0APP, SNCA, MAPT
49inclusion body myositis10.0RPS27A, APP, MAPT
50prion disease10.0MAPT, PRNP, APP

Graphical network of the top 20 diseases related to Aphasia:



Diseases related to aphasia

Clinical Features for Aphasia

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Drugs & Therapeutics for Aphasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Aphasia

Drug clinical trials:

Search ClinicalTrials for Aphasia

Search NIH Clinical Center for Aphasia

Search CenterWatch for Aphasia

Genetic Tests for Aphasia

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Anatomical Context for Aphasia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Aphasia:

32
Brain, Testes, Cortex, Temporal lobe, Skin, Prefrontal cortex, Parietal lobe

Animal Models for Aphasia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Aphasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.0LGI1, LRRK2, GRN, L1CAM
2MP:00030129.3LRRK2, L1CAM, ISL2, APP, SNCB, SNCA
3MP:00053869.1L1CAM, FEV, APP, SNCA, PRNP, GRN
4MP:00053769.1SNCA, SNCB, APP, FEV, PRNP, GRN
5MP:00036319.0L1CAM, FEV, ISL2, APP, SNCB, SNCA
6MP:00053849.0SNCA, APP, ISL2, FEV, L1CAM, PRNP
7MP:00053789.0L1CAM, ISL2, APP, SNCB, SNCA, PRNP
8MP:00107688.8SNCA, SNCB, APP, ISL2, FEV, L1CAM

Publications for Aphasia

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Sources:
50PubMed
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Articles related to Aphasia:

(show top 50)    (show all 839)
idTitleAuthorsYear
1
Sensory-specific anomic aphasia following left occipital lesions: Data from free oral descriptions of concrete word meanings. (23425233)
2014
2
In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology. (24353332)
2014
3
MM1+2C Sporadic Creutzfeldt-Jakob Disease Presenting as Rapidly Progressive Nonfluent Aphasia. (24121954)
2014
4
Primary progressive aphasia and the language network: the 2013 H. Houston Merritt Lecture. (23897873)
2013
5
The incidence, co-occurrence, and predictors of dysphagia, dysarthria, and aphasia after first-ever acute ischemic stroke. (23642855)
2013
6
Aphasia rehabilitation in Australia: Current practices, challenges and future directions. (23777446)
2013
7
Implicit and Explicit Learning in Individuals with Agrammatic Aphasia. (23532578)
2013
8
Transcranial direct current stimulation (tDCS) for improving aphasia in patients after stroke. (23799617)
2013
9
tDCS stimulation segregates words in the brain: evidence from aphasia. (23785323)
2013
10
Treatment fidelity: its importance and reported frequency in aphasia treatment studies. (23695904)
2013
11
Setting a research agenda to inform intensive comprehensive aphasia programs. (24091283)
2013
12
Naming vs knowing faces in primary progressive aphasia: a tale of 2 hemispheres. (23940020)
2013
13
Rehabilitation in bilingual aphasia: evidence for within- and between-language generalization. (23695906)
2013
14
Sporadic Jakob-Creutzfeldt disease presenting as primary progressive aphasia. (23400721)
2013
15
An Enhanced Protocol for CI Aphasia Therapy: CIAT II - A Case Series. (24018698)
2013
16
Effect of two layouts on high technology AAC navigation and content location by people with aphasia. (23692409)
2013
17
A clinical, neurolinguistic, and radiological study of a Chinese follow-up case with primary progressive aphasia. (22827556)
2013
18
Clinician perspectives of an intensive comprehensive aphasia program. (24091282)
2013
19
Training verb argument structure production in agrammatic aphasia: behavioral and neural recovery patterns. (23514929)
2013
20
"Making a good time": the role of friendship in living successfully with aphasia. (22713174)
2013
21
Further evidence of auditory extinction in aphasia. (23165975)
2013
22
Memory and Orientation in the Logopenic and Nonfluent Subtypes of Primary Progressive Aphasia. (24321890)
2013
23
Effects of dual transcranial direct current stimulation for aphasia in chronic stroke patients. (24233579)
2013
24
Dystypia without aphasia associated with visuospatial memory impairment in a patient with acute stroke. (21959361)
2012
25
The time-course of lexical activation during sentence comprehension in people with aphasia. (22355007)
2012
26
Treating verbs in aphasia: exploring the impact of therapy at the single word and sentence levels. (23121523)
2012
27
Speech therapy in primary progressive aphasia: a pilot study. (22962556)
2012
28
The neural basis of reversible sentence comprehension: evidence from voxel-based lesion symptom mapping in aphasia. (21861679)
2012
29
Expressive aphasia: an isolated and reversible complication of cerebral malaria in a child. (22898486)
2012
30
Effects of word frequency and modality on sentence comprehension impairments in people with aphasia. (22294411)
2012
31
Computer-Mediated Assessment of Intelligibility in Aphasia and Apraxia of Speech. (22215933)
2011
32
Classification of primary progressive aphasia and its variants. (21325651)
2011
33
Community: the key to building and extending engagement for individuals with aphasia. (21968561)
2011
34
Patterns of breakdown in spelling in primary progressive aphasia. (20060967)
2011
35
Lexical competition for production in a case of nonfluent aphasia: converging evidence from four different tasks. (21864200)
2010
36
Primary progressive aphasia: a comparative study of progressive nonfluent aphasia and semantic dementia. (16010052)
2005
37
Evidence of bilateral temporal lobe involvement in primary progressive aphasia: a SPECT study. (12843214)
2003
38
Aphasia in corticobasal degeneration. (10624476)
2000
39
Optic aphasia with pure alexia: a mild form of visual associative agnosia? A case study. (9669108)
1998
40
Index of suspicion. Case 3. Aseptic meningitis with aphasia. (8516243)
1993
41
Anterior opercular cortex lesions cause dissociated lower cranial nerve palsies and anarthria but no aphasia: Foix-Chavany-Marie syndrome and "automatic voluntary dissociation" revisited. (7684439)
1993
42
Non-specific X linked mental retardation with aphasia exhibiting genetic linkage to chromosomal region Xp11. (1357179)
1992
43
The Landau-Kleffner syndrome or 'acquired aphasia with convulsive disorder'. Long-term follow-up of six children and a review of the recent literature. (1558514)
1992
44
Primary progressive non-fluent aphasia: a case study. (2055038)
1991
45
Acquired aphasia with seizure disorder in childhood. (2473957)
1989
46
Landau-Kleffner syndrome--epileptic aphasia in children--possible role of toxoplasma gondii infection. (2479399)
1988-1989
47
The aphasia-epilepsy syndrome in children: electroencephalographic aspects. (7067150)
1982
48
Acquired aphasia in childhood with seizure disorder: a heterogeneous syndrome. (578297)
1977
49
Clinical and EEG analysis of the role of subcortical structures in the mechanisms of aphasia and anosognosia. (4181478)
1969
50
Mental symptoms as phenomena of agnosia, apraxia, and aphasia. (13583223)
1958

Genetic Variations for Aphasia

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Expression for genes affiliated with Aphasia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aphasia

Search GEO for disease gene expression data for Aphasia.

Pathways for genes affiliated with Aphasia

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Sources:
4Cell Signaling Technology
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Pathways related to Aphasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8LRRK2, TARDBP, MAPT, SNCA, SNCB, APP

Compounds for genes affiliated with Aphasia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Aphasia according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1tmao4410.5SNCA, MAPT
2thioflavin4410.5MAPT, SNCA, APP
3thioflavin t4410.5APP, SNCA
46-hydroxydopamine4410.4SNCA, APP, RPS27A
5tacrine44 1111.4MAPT, APP
6guanidine hydrochloride4410.4PRNP, SNCA, RPS27A
7thioflavine s4410.4MAPT, SNCA, APP, RPS27A
8silver4410.3MAPT, SNCA, RPS27A
94-hydroxynonenal44 2411.3RPS27A, APP, SNCA, MAPT
10lactacystin4410.3MAPT, SNCA, APP, RPS27A
11formaldehyde44 2411.3RPS27A, APP, PRNP, MAPT
12methionine sulfoxide44 11 2412.3APP, SNCA
13chloroquine44 2 49 28 1114.3RPS27A, APP, MAPT
14formate4410.3RPS27A, APP, SNCA, PRNP, MAPT
15donepezil44 11 2412.2APP, MAPT
16memantine44 28 1112.2MAPT, APP
17sodium dodecylsulfate4410.2RPS27A, APP, SNCA, PRNP, MAPT
18valine4410.2MAPT, PRNP, SNCA, APP, RPS27A
19levodopa44 1111.2LRRK2, SNCA, RPS27A
20dopamine44 28 11 2413.2LRRK2, MAPT, SNCA, APP, RPS27A
21h2o24410.1RPS27A, APP, SNCB, SNCA, PRNP, MAPT
22glutamate4410.1RPS27A, L1CAM, APP, SNCA, PRNP, MAPT
23testosterone44 59 11 2412.7RPS27A, APP, SNCA, MAPT, SLC22A7
24acetylcholine44 49 28 11 2413.7MAPT, SNCA, APP, RPS27A

GO Terms for genes affiliated with Aphasia

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Sources:
16Gene Ontology
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Cellular components related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:03042610.1MAPT, SNCA, SNCB
2terminal boutonGO:0431959.8SNCA, SNCB, L1CAM

Biological processes related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of locomotionGO:04001210.2LRRK2, SNCA
2axon cargo transportGO:00808810.1APP, MAPT
3response to oxidative stressGO:00697910.1LRRK2, PRNP, APP
4cell deathGO:00821910.1TARDBP, GRN, CHMP2B, L1CAM
5cellular copper ion homeostasisGO:0068789.9PRNP, APP

Molecular functions related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.8LRRK2, TARDBP, PRNP, SNCA, APP, L1CAM

Products for genes affiliated with Aphasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aphasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet