Summaries for Aphasia

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MedlinePlus:34 Aphasia is a disorder caused by damage to the parts of the brain that control language. it can make it hard for you to read, write, and say what you mean to say. it is most common in adults who have had a stroke. brain tumors, infections, injuries, and dementia can also cause it. the type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. there are four main types: expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean receptive aphasia - you hear the voice or see the print, but you can't make sense of the words anomic aphasia - you have trouble using the correct word for objects, places, or events global aphasia - you can't speak, understand speech, read, or write some people recover from aphasia without treatment. most, however, need language therapy as soon as possible. nih: national institute of neurological disorders and stroke

MalaCards based summary: Aphasia is related to apraxia and dementia. An important gene associated with Aphasia is L1CAM (L1 cell adhesion molecule). The compounds tmao and sodium dodecylsulfate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are no phenotypic analysis and nervous system.

Disease Ontology:10 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.

NINDS:44 Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language. Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Most commonly seen in adults who have suffered a stroke, aphasia can also result from a brain tumor, infection, head injury, or dementia that damages the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue.

Wikipedia:65 Aphasia (/??fe???/, /??fe?zi?/ or /e??fe?zi?/; from Greek a- (\"without\") + ph more...

Aliases & Classifications for Aphasia

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Aphasia, Aliases & Descriptions:

Name: Aphasia 10 44 12 45 34 62


External Ids:

Disease Ontology10 DOID:0060046

Related Diseases for Aphasia

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Diseases related to Aphasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 343)
idRelated DiseaseScoreTop Affiliating Genes
1apraxia31.0GRN, MAPT
2dementia31.0APOC1, MAPT, GRN, TARDBP
3semantic dementia30.8MAPT, GRN
4frontotemporal lobar degeneration with ubiquitin-positive inclusions30.6GRN, MAPT
5dementia, frontotemporal30.0TARDBP, GRN, MAPT
6pick disease29.9MAPT, TARDBP
7tauopathy29.9MAPT, GRN
8alzheimer disease29.8TARDBP, GRN, MAPT, TOMM40, APOC1
9supranuclear palsy, progressive29.7TARDBP, GRN, MAPT
10motor neuron disease29.7MAPT, GRN, TARDBP
11landau-kleffner syndrome10.6
12logopenic progressive aphasia10.5
13progressive non-fluent aphasia10.5
14agnosia10.5
15alexia10.4
16nominal aphasia10.4
17corticobasal degeneration10.4
18cerebritis10.3
19masa syndrome10.2
20agraphia10.2
21blindness10.2
22ideomotor apraxia10.2
23gerstmann syndrome10.2
24dysgraphia10.2
25encephalitis10.2
26epilepsy, focal, with speech disorder and with or without mental retardation10.1
27creutzfeldt-jakob disease10.1
28anosognosia10.1
29lateral sclerosis10.0
30auditory agnosia10.0
31associative agnosia10.0
32amusia10.0
33anterior cerebral artery infarction10.0
34epilepsy syndrome10.0
35hemiplegia10.0
36learning disability10.0
37seizure disorder10.0
38hydrocephalus10.0MAPT, L1CAM
39amyotrophic lateral sclerosis 110.0TARDBP, GRN, MAPT
40moyamoya disease10.0
41sialidosis, type i10.0
42leukemia10.0
43neuronitis10.0
44mutism10.0
45dyslexia10.0
46typhoid fever10.0
47transient global amnesia10.0
48meningitis10.0
49visual agnosia10.0
50flynn aird syndrome10.0

Graphical network of the top 20 diseases related to Aphasia:



Diseases related to aphasia

Symptoms for Aphasia

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Drugs & Therapeutics for Aphasia

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Drug clinical trials:

Search ClinicalTrials for Aphasia

Search NIH Clinical Center for Aphasia

Genetic Tests for Aphasia

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Anatomical Context for Aphasia

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MalaCards organs/tissues related to Aphasia:

33
Brain, Testes, Cortex, Temporal lobe, Skin, Prefrontal cortex, Parietal lobe

Animal Models for Aphasia or affiliated genes

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MGI Mouse Phenotypes related to Aphasia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6TARDBP, GRN, MAPT, L1CAM
2MP:00036318.6TARDBP, GRN, MAPT, L1CAM
3MP:00053868.5L1CAM, MAPT, GRN, TARDBP
4MP:00053848.3L1CAM, MAPT, GRN, TARDBP

Publications for Aphasia

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Articles related to Aphasia:

(show top 50)    (show all 904)
idTitleAuthorsYear
1
Distinct loci of lexical and semantic access deficits in aphasia: Evidence from voxel-based lesion-symptom mapping and diffusion tensor imaging. (25880795)
2015
2
Frontotemporal dementia and primary progressive aphasia, a review. (24966676)
2014
3
Options to enhance recovery from aphasia by means of non-invasive brain stimulation and action observation therapy. (24308276)
2014
4
A case of pathology-proven neuromyelitis optica spectrum disorder with SjAPgren syndrome manifesting aphasia and apraxia due to a localized cerebral white matter lesion. (24986696)
2014
5
Frontal white matter tracts sustaining speech production in primary progressive aphasia. (25031413)
2014
6
Learning to fail in aphasia: an investigation of error learning in naming. (23816662)
2013
7
The World Report on Disability as a blueprint for international, national, and local aphasia services. (23101515)
2013
8
Neural systems underlying the influence of sound shape properties of the lexicon on spoken word production: do fMRI findings predict effects of lesions in aphasia? (23743183)
2013
9
Aphasia Predicts Unfavorable Outcome in Mild Ischemic Stroke Patients and Prompts Thrombolytic Treatment. (23352114)
2013
10
Non-invasive brain stimulation (rTMS and tDCS) in patients with aphasia: mode of action at the cellular level. (23872450)
2013
11
Young patient with aphasia, monoparesis, facial drop, facial sensory loss, diplopia, dysarthria, and vertical gaze palsy. (24130136)
2013
12
Writing treatment for aphasia: a texting approach. (23811474)
2013
13
Handedness and language learning disability differentially distribute in progressive aphasia variants. (24056533)
2013
14
Clinical genetic study of the epilepsy-aphasia spectrum. (23294109)
2013
15
Prediction of aphasia outcome using diffusion tensor tractography for arcuate fasciculus in stroke. (23042924)
2013
16
Identification of an atypical variant of logopenic progressive aphasia. (23566690)
2013
17
White matter in aphasia: a historical review of the Dejerines' studies. (23895939)
2013
18
Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia. (23395096)
2013
19
Classification and pathology of primary progressive aphasia. (24142474)
2013
20
Steps to success with technology for individuals with aphasia. (22851345)
2012
21
FOXP2, APOE, and PRNP: new modulators in primary progressive aphasia. (22129783)
2012
22
Aphasia rehabilitation: more than treating the language disorder. (22119073)
2012
23
Crossed aphasia in a dextral patient with logopenic/phonological variant of primary progressive aphasia. (21959362)
2012
24
Non-verbal communication in severe aphasia: influence of aphasia, apraxia, or semantic processing? (21458789)
2012
25
Prolonged ictal aphasia: a diagnosis to consider. (22925412)
2012
26
Borderzone strokes and transcortical aphasia. (21904919)
2011
27
Computer-Mediated Assessment of Intelligibility in Aphasia and Apraxia of Speech. (22215933)
2011
28
Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation. (20479359)
2010
29
Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia. (20400120)
2010
30
From singing to speaking: facilitating recovery from nonfluent aphasia. (21088709)
2010
31
Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanism. (18679537)
2008
32
Foreign accent syndrome as the initial sign of primary progressive aphasia. (17635973)
2008
33
Visuomotor tracking abilities of speakers with apraxia of speech or conduction aphasia. (18558428)
2008
34
Primary progressive aphasia: relationship between gender and severity of language impairment. (17356343)
2007
35
A review on primary progressive aphasia. (19300609)
2007
36
A cocaine-associated quadriplegia and motor aphasia after first use of cocaine. (17724897)
2007
37
The mini-mental state examination in behavioral variant frontotemporal dementia and primary progressive aphasia. (18166606)
2007
38
Apoe epsilon2-epsilon4 genotype is a possible risk factor for primary progressive aphasia. (16437577)
2006
39
Aphasia, alexia, and oral reading. (14872397)
2004
40
Deterioration of naming nouns versus verbs in primary progressive aphasia. (14755731)
2004
41
Primary progressive aphasia: a review. (15849155)
2004
42
Acquired alexia in multilingual aphasia and computer-assisted treatment in both languages: issues of generalisation and transfer. (11316940)
2001
43
Frontotemporal decreases in rCBF correlate with degree of dysnomia in primary progressive aphasia. (10688104)
2000
44
Aphasia in corticobasal degeneration. (10624476)
2000
45
An autopsy case of Alzheimer's disease presenting with primary progressive aphasia: a clinicopathological and immunohistochemical study. (11132942)
2000
46
Developmental delay, expressive aphasia, hypotonia and dysmorphism in two brothers: an X-linked mental retardation syndrome? (9843001)
1998
47
Primary progressive aphasia and frontal lobe involvement. (8559410)
1996
48
Dissociation of anosognosia for hemiplegia and aphasia during left-hemisphere anesthesia. (7824138)
1995
49
Wernicke's and global aphasia without alexia. (435133)
1979
50
Aphasia, apraxia, and agnosia; a new classification. (21017997)
1946

Variations for Aphasia

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Expression for genes affiliated with Aphasia

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Search GEO for disease gene expression data for Aphasia.

Pathways for genes affiliated with Aphasia

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Compounds for genes affiliated with Aphasia

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Sources:
45Novoseek, 51PharmGKB, 13DrugBank
See all sources

Compounds related to Aphasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tmao459.4MAPT, APOC1
2sodium dodecylsulfate459.2APOC1, MAPT
3antivirals for treatment of hiv infections, combinations519.1TOMM40, APOC1
4ritonavir45 51 1311.0TOMM40, APOC1
5glucose458.9GRN, MAPT, APOC1
6estrogen458.6GRN, MAPT, APOC1

GO Terms for genes affiliated with Aphasia

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Biological processes related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:00082199.1TARDBP, GRN, L1CAM

Products for genes affiliated with Aphasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Aphasia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet