MCID: APH002
MIFTS: 44

Aphasia malady

Genetic diseases, Fetal diseases, Rare diseases categories
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Summaries for Aphasia

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MedlinePlus:33 Aphasia is a disorder caused by damage to the parts of the brain that control language. it can make it hard for you to read, write, and say what you mean to say. it is most common in adults who have had a stroke. brain tumors, infections, injuries, and dementia can also cause it. the type of problem you have and how bad it is depends on which part of your brain is damaged and how much damage there is. there are four main types: expressive aphasia - you know what you want to say, but you have trouble saying or writing what you mean receptive aphasia - you hear the voice or see the print, but you can't make sense of the words anomic aphasia - you have trouble using the correct word for objects, places, or events global aphasia - you can't speak, understand speech, read, or write some people recover from aphasia without treatment. most, however, need language therapy as soon as possible. nih: national institute of neurological disorders and stroke

MalaCards based summary: Aphasia is related to primary progressive aphasia and semantic dementia. An important gene associated with Aphasia is L1CAM (L1 cell adhesion molecule). The compounds tmao and sodium dodecylsulfate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are no phenotypic analysis and nervous system.

Disease Ontology:8 A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language.

NINDS:43 Aphasia is a neurological disorder caused by damage to the portions of the brain that are responsible for language. Primary signs of the disorder include difficulty in expressing oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is not a disease, but a symptom of brain damage. Most commonly seen in adults who have suffered a stroke, aphasia can also result from a brain tumor, infection, head injury, or dementia that damages the brain. It is estimated that about 1 million people in the United States today suffer from aphasia. The type and severity of language dysfunction depends on the precise location and extent of the damaged brain tissue.

Wikipedia:65 Aphasia (/??fe???/, /??fe?zi?/ or /e??fe?zi?/) is a disturbance of the comprehension and expression of... more...

Aliases & Classifications for Aphasia

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Aphasia, Aliases & Descriptions:

Name: Aphasia 8 43 10 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Fetal diseases, Rare diseases


External Ids:

Disease Ontology8 DOID:0060046

Related Diseases for Aphasia

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Diseases in the Primary Progressive Aphasia family:

aphasia

Diseases related to Aphasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 358)
idRelated DiseaseScoreTop Affiliating Genes
1primary progressive aphasia31.7GRN, MAPT
2semantic dementia31.0MAPT, GRN
3apraxia31.0GRN, MAPT
4frontotemporal lobar degeneration with ubiquitin-positive inclusions30.6GRN
5frontotemporal dementia30.6TARDBP, GRN, MAPT
6dementia30.5APOC1, MAPT, GRN, TARDBP
7pick's disease30.3MAPT, TARDBP
8progressive supranuclear palsy30.3TARDBP, GRN, MAPT
9tauopathy29.9MAPT, GRN
10memory impairment29.7APOC1, MAPT, GRN
11alzheimer's disease29.6TARDBP, GRN, MAPT, TOMM40, APOC1
12motor neuron disease29.5MAPT, GRN, TARDBP
13landau-kleffner syndrome10.6
14logopenic progressive aphasia10.5
15progressive non-fluent aphasia10.5
16agnosia10.5
17alexia10.4
18corticobasal degeneration10.4
19nominal aphasia10.4
20cerebritis10.3
21blindness10.2
22ideomotor apraxia10.2
23gerstmann syndrome10.2
24dysgraphia10.1
25spastic paraplegia 110.1
26anosognosia10.1
27encephalitis10.1
28lateral sclerosis10.0
29creutzfeldt-jakob disease10.0
30associative agnosia10.0
31auditory agnosia10.0
32amusia10.0
33neuronitis10.0
34anterior cerebral artery infarction10.0
35epilepsy syndrome10.0
36hemiplegia10.0
37seizure disorder10.0
38epilepsy, focal, with speech disorder and with or without mental retardation10.0
39amyotrophic lateral sclerosis9.9
40leukemia9.9
41parkinson's disease9.9
42x-linked ichthyosis9.9
43typhoid fever9.9
44moyamoya disease9.9
45transient global amnesia9.9
46dyslexia9.9
47mutism9.9
48learning disability9.9
49meningitis9.9
50visual agnosia9.9

Graphical network of the top 20 diseases related to Aphasia:



Diseases related to aphasia

Symptoms for Aphasia

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Drugs & Therapeutics for Aphasia

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Drug clinical trials:

Search ClinicalTrials for Aphasia

Search NIH Clinical Center for Aphasia

Genetic Tests for Aphasia

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Anatomical Context for Aphasia

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MalaCards organs/tissues related to Aphasia:

32
Brain, Testes, Cortex, Temporal lobe, Skin, Prefrontal cortex, Parietal lobe

Animal Models for Aphasia or affiliated genes

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MGI Mouse Phenotypes related to Aphasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6TARDBP, GRN, MAPT, L1CAM
2MP:00036318.6TARDBP, GRN, MAPT, L1CAM
3MP:00053868.5L1CAM, MAPT, GRN, TARDBP
4MP:00053848.3L1CAM, MAPT, GRN, TARDBP

Publications for Aphasia

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Articles related to Aphasia:

(show top 50)    (show all 867)
idTitleAuthorsYear
1
Frontotemporal dementia and primary progressive aphasia, a review. (24966676)
2014
2
Options to enhance recovery from aphasia by means of non-invasive brain stimulation and action observation therapy. (24308276)
2014
3
A case of pathology-proven neuromyelitis optica spectrum disorder with SjAPgren syndrome manifesting aphasia and apraxia due to a localized cerebral white matter lesion. (24986696)
2014
4
Frontal white matter tracts sustaining speech production in primary progressive aphasia. (25031413)
2014
5
Learning to fail in aphasia: an investigation of error learning in naming. (23816662)
2013
6
The World Report on Disability as a blueprint for international, national, and local aphasia services. (23101515)
2013
7
Neural systems underlying the influence of sound shape properties of the lexicon on spoken word production: do fMRI findings predict effects of lesions in aphasia? (23743183)
2013
8
Aphasia Predicts Unfavorable Outcome in Mild Ischemic Stroke Patients and Prompts Thrombolytic Treatment. (23352114)
2013
9
Non-invasive brain stimulation (rTMS and tDCS) in patients with aphasia: mode of action at the cellular level. (23872450)
2013
10
Young patient with aphasia, monoparesis, facial drop, facial sensory loss, diplopia, dysarthria, and vertical gaze palsy. (24130136)
2013
11
Writing treatment for aphasia: a texting approach. (23811474)
2013
12
Handedness and language learning disability differentially distribute in progressive aphasia variants. (24056533)
2013
13
Clinical genetic study of the epilepsy-aphasia spectrum. (23294109)
2013
14
Prediction of aphasia outcome using diffusion tensor tractography for arcuate fasciculus in stroke. (23042924)
2013
15
Identification of an atypical variant of logopenic progressive aphasia. (23566690)
2013
16
White matter in aphasia: a historical review of the Dejerines' studies. (23895939)
2013
17
Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia. (23395096)
2013
18
Classification and pathology of primary progressive aphasia. (24142474)
2013
19
FOXP2, APOE, and PRNP: new modulators in primary progressive aphasia. (22129783)
2012
20
Crossed aphasia in a dextral patient with logopenic/phonological variant of primary progressive aphasia. (21959362)
2012
21
Prolonged ictal aphasia: a diagnosis to consider. (22925412)
2012
22
Borderzone strokes and transcortical aphasia. (21904919)
2011
23
Computer-Mediated Assessment of Intelligibility in Aphasia and Apraxia of Speech. (22215933)
2011
24
Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation. (20479359)
2010
25
Phenomenology and anatomy of abnormal behaviours in primary progressive aphasia. (20400120)
2010
26
From singing to speaking: facilitating recovery from nonfluent aphasia. (21088709)
2010
27
Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanism. (18679537)
2008
28
Foreign accent syndrome as the initial sign of primary progressive aphasia. (17635973)
2008
29
Visuomotor tracking abilities of speakers with apraxia of speech or conduction aphasia. (18558428)
2008
30
Primary progressive aphasia: relationship between gender and severity of language impairment. (17356343)
2007
31
A review on primary progressive aphasia. (19300609)
2007
32
A cocaine-associated quadriplegia and motor aphasia after first use of cocaine. (17724897)
2007
33
The mini-mental state examination in behavioral variant frontotemporal dementia and primary progressive aphasia. (18166606)
2007
34
Primary progressive aphasia: a case report. (17965034)
2007
35
Apoe epsilon2-epsilon4 genotype is a possible risk factor for primary progressive aphasia. (16437577)
2006
36
A case study of Primary Progressive Aphasia: improvement on verbs after rTMS treatment. (17182394)
2006
37
Different patterns of Mini Mental Status Examination responses in primary progressive aphasia and Alzheimer's disease. (16987166)
2006
38
Aphasia, alexia, and oral reading. (14872397)
2004
39
Deterioration of naming nouns versus verbs in primary progressive aphasia. (14755731)
2004
40
Primary progressive aphasia: a review. (15849155)
2004
41
Acquired alexia in multilingual aphasia and computer-assisted treatment in both languages: issues of generalisation and transfer. (11316940)
2001
42
Frontotemporal decreases in rCBF correlate with degree of dysnomia in primary progressive aphasia. (10688104)
2000
43
Aphasia in corticobasal degeneration. (10624476)
2000
44
An autopsy case of Alzheimer's disease presenting with primary progressive aphasia: a clinicopathological and immunohistochemical study. (11132942)
2000
45
Developmental delay, expressive aphasia, hypotonia and dysmorphism in two brothers: an X-linked mental retardation syndrome? (9843001)
1998
46
Primary progressive aphasia and frontal lobe involvement. (8559410)
1996
47
Dissociation of anosognosia for hemiplegia and aphasia during left-hemisphere anesthesia. (7824138)
1995
48
Acquired aphasia with seizure disorder in childhood. (2473957)
1989
49
Wernicke's and global aphasia without alexia. (435133)
1979
50
Aphasia, apraxia, and agnosia; a new classification. (21017997)
1946

Variations for Aphasia

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Expression for genes affiliated with Aphasia

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Expression patterns in normal tissues for genes affiliated with Aphasia

Search GEO for disease gene expression data for Aphasia.

Pathways for genes affiliated with Aphasia

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Compounds for genes affiliated with Aphasia

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank
See all sources

Compounds related to Aphasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tmao449.4MAPT, APOC1
2sodium dodecylsulfate449.2APOC1, MAPT
3antivirals for treatment of hiv infections, combinations509.1TOMM40, APOC1
4ritonavir44 50 1111.0TOMM40, APOC1
5glucose448.9GRN, MAPT, APOC1
6estrogen448.6GRN, MAPT, APOC1

GO Terms for genes affiliated with Aphasia

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Biological processes related to Aphasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082199.1TARDBP, GRN, L1CAM

Products for genes affiliated with Aphasia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Aphasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet