MCID: APH001
MIFTS: 53

Aphthous Stomatitis malady

Rare diseases, Oral diseases categories

Summaries for Aphthous Stomatitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Aphthous stomatitis (also termed recurrent aphthous stomatitis, recurring oral aphthae or recurrent... more...

MalaCards: Aphthous Stomatitis, also known as aphthous ulceration, is related to behcet's disease and proliferative glomerulonephritis. An important gene associated with Aphthous Stomatitis is TNF (tumor necrosis factor), and among its related pathways are TRAF Pathway and Pertussis. The drug thalidomide and the compounds mycophenolate mofetil and groalpha have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and t cells, and related mouse phenotypes are tumorigenesis and respiratory system.

Aliases & Classifications for Aphthous Stomatitis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Oral diseases


Aliases & Descriptions:

aphthous stomatitis 9 44 11 63
aphthous ulceration 9
oral aphthae 9
canker sore 9
aphtha 9


Related Diseases for Aphthous Stomatitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Aphthous Stomatitis:



Diseases related to aphthous stomatitis

Symptoms for Aphthous Stomatitis

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Drugs & Therapeutics for Aphthous Stomatitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Aphthous Stomatitis

Drug clinical trials:

Search ClinicalTrials for Aphthous Stomatitis

Search NIH Clinical Center for Aphthous Stomatitis

Search CenterWatch for Aphthous Stomatitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Aphthous Stomatitis

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Anatomical Context for Aphthous Stomatitis

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34MalaCards
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MalaCards organs/tissues related to Aphthous Stomatitis:

34
Testes, Heart, T cells, Monocytes, Endothelial, Tonsil

Animal Models for Aphthous Stomatitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Aphthous Stomatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1IL12A, CXCR3, TNF
2MP:00053888.5IL12A, CCR1, CXCR3, TNF
3MP:00053978.0TNF, CXCR3, MEFV, CCR1, IL12A
4MP:00053877.9TNF, CXCR3, MEFV, CCR1, IL12A
5MP:00107687.6TNF, CXCR3, MEFV, CCR1, IL12A
6MP:00053767.2IL12A, CCR1, MEFV, CXCR3, TNF, CFI

Publications for Aphthous Stomatitis

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53PubMed
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Articles related to Aphthous Stomatitis:

(show top 50)    (show all 465)
idTitleAuthorsYear
1
Assessment of immediate pain relief with laser treatment in recurrent aphthous stomatitis. (23622766)
2013
2
Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study. (24268387)
2013
3
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. (24134207)
2013
4
Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects: Literature Review. (24217985)
2013
5
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)
2012
6
Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). (22972085)
2012
7
Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. (23162576)
2012
8
Review of the current evidence on the diagnosis and management of recurrent aphthous stomatitis. (21212925)
2011
9
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)
2010
10
Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. (20173724)
2010
11
Endothelial nitric oxide synthase gene polymorphisms are not associated with recurrent aphthous stomatitis. (19410237)
2009
12
Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome. (19209090)
2009
13
Randomised controlled trial of the efficacy of HybenX in the symptomatic treatment of recurrent aphthous stomatitis. (19207485)
2009
14
Recalcitrant, recurrent aphthous stomatitis successfully treated with adalimumab. (18482322)
2009
15
Recurrent aphthous stomatitis may be initiated by traumatic epithelial implantation and sustained by localized pathergic status. (17768013)
2008
16
Effectiveness of two oral pastes for the treatment of recurrent aphthous stomatitis. (17714352)
2007
17
Detection, enumeration and characterization of T helper cells secreting type 1 and type 2 cytokines in patients with recurrent aphthous stomatitis. (17548954)
2007
18
Imerslund-Grasbeck syndrome associated with recurrent aphthous stomatitis and defective neutrophil function. (17114957)
2006
19
Erythrocyte superoxide dismutase, catalase activities and plasma nitrite and nitrate levels in patients with BehAset disease and recurrent aphthous stomatitis. (14987277)
2004
20
Aphthous stomatitis induced by piroxicam. (15034523)
2004
21
Results of double-blind placebo-controlled challenge with nickel salts in patients affected by recurrent aphthous stomatitis. (12915773)
2003
22
Utility of tonsillectomy in 2 patients with the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. (12810475)
2003
23
Comparison of oral aphthae in BehAset's disease and idiopathic recurrent aphthous stomatitis. (12918713)
2003
24
IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS). (12140751)
2002
25
Close association of HLA-B52 and HLA-B44 antigens in Israeli Arab adolescents with recurrent aphthous stomatitis. (11177036)
2001
26
Oral and maxillofacial pathology case of the month. Recurrent aphthous stomatitis--herpetiform type. (11857822)
2000
27
Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. (10393612)
1999
28
Elevated levels of interferon gamma, tumor necrosis factor alpha, interleukins 2, 4, and 5, but not interleukin 10, are present in recurrent aphthous stomatitis. (9681346)
1998
29
Decreased levels of salivary prostaglandin E2 and epidermal growth factor in recurrent aphthous stomatitis. (8850647)
1995
30
Aphthous stomatitis and its management. (1807480)
1991
31
Phenotypic identification of T lymphocytes subset in recurrent aphthous stomatitis. (2152028)
1990
32
Recurrent aphthous stomatitis: otolaryngological interest. (3775127)
1986
33
Screening for haematinic deficiencies in patients with recurrent aphthous stomatitis. (3632516)
1986
34
Recurrent aphthous stomatitis. (4025106)
1985
35
Recurrent aphthous stomatitis. (6674353)
1983
36
Levamisole in recurrent aphthous stomatitis. (6644050)
1983
37
Recurrent aphthous stomatitis: review of the literature. (6214531)
1982
38
Effects of suspected foodstuff challenging agents in the etiology of recurrent aphthous stomatitis. (6956825)
1982
39
Premonitory stages of recurrent aphthous stomatitis. I. Histological and enzyme histochemical investigations. (6776249)
1980
40
Double-blind study of levamisole in aphthous stomatitis. (105099)
1978
41
Evaluation of the therapeutic effect of levamisole in treatment of recurrent aphthous stomatitis. (105100)
1978
42
Etiology, pathogenesis and classification of aphthous stomatitis and BehAset's syndrome. (105093)
1978
43
Aphthous stomatitis as a featuring syndrome of emotional stress in dental treatment. (1076577)
1976
44
Letter: Treatment of recurrent aphthous stomatitis and herpes with levamisole. (4611586)
1974
45
Treatment of aphthous stomatitis by suppression of intralesional streptococci. (4814943)
1974
46
Recurrent aphthous stomatitis. Clinical, therapeutic, histopathologic, and hypersensitivity aspects. (5952294)
1966
47
L FORM OF BACTERIA ISOLATED FROM RECURRENT APHTHOUS STOMATITIS LESIONS. (14082315)
1963
48
Virological and serological investigation of acute aphthous stomatitis in children. (14448353)
1960
49
Recurrent ulcerative (aphthous) stomatitis: intradermal food test studies. (13575065)
1958
50
Antihistaminic agents in the treatment of recurrent aphthous stomatitis. (13037294)
1953

Variations for Aphthous Stomatitis

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Expression for genes affiliated with Aphthous Stomatitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aphthous Stomatitis

Search GEO for disease gene expression data for Aphthous Stomatitis.

Pathways for genes affiliated with Aphthous Stomatitis

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51PathCards, 54QIAGEN, 31KEGG, 55R&D Systems, 39NCBI BioSystems Database, 56Reactome, 13EMD Millipore
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Pathways related to Aphthous Stomatitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1TNF
29.6IL12A, TNF
3
Show member pathways
IL27-mediated signaling events39
9.6TNF, IL12A
4
Show member pathways
9.6IL12A, TNF
59.6IL12A, TNF
6
Show member pathways
9.6IL12A, TNF
79.6IL12A, TNF
89.6TNF, IL12A
99.6TNF, IL12A
109.6IL12A, TNF
11
Show member pathways
9.6TNF, IL12A
129.6IL12A, TNF
13
Show member pathways
9.4TNF, MEFV
14
Show member pathways
Peptide GPCRs39
9.4CXCR3, CCR1
15
Show member pathways
9.4CCR1, CXCR3
16
Show member pathways
8.6TNF, CXCR3, CCR1, IL12A
17
Show member pathways
8.6TNF, CXCR3, CCR1, IL12A
18
Show member pathways
8.6IL12A, CCR1, CXCR3, TNF
19
Show member pathways
8.6IL12A, TNF, CXCR3, CCR1

Compounds for genes affiliated with Aphthous Stomatitis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Aphthous Stomatitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1mycophenolate mofetil46 52 1211.9TNF, IL12A
2groalpha469.9CXCR3, TNF
3etanercept46 52 1211.8CXCR3, TNF
4il 10469.8TNF, CXCR3
5ccl13309.8CXCR3, CCR1
6infliximab46 52 1211.8CXCR3, TNF
7ccl7309.8CXCR3, CCR1
8ccl5309.8CXCR3, CCR1
9tarc469.8CXCR3, TNF
10leukotriene b446 62 2511.6CCR1, TNF
11ccl446 3010.6CCR1, CXCR3
12aebsf469.6TNF, CFI
13fmlp469.5CXCR3, TNF
14hydrocortisone46 3 62 1212.4TNF, CXCR3
15ccl346 3010.4CCR1, CXCR3, TNF
16rantes469.4TNF, CXCR3, CCR1
17pge2469.3TNF, CXCR3, CCR1
18superoxide46 2510.3CCR1, CXCR3, TNF
19endotoxin469.3MEFV, CXCR3, TNF
20dexamethasone46 52 30 1212.1TNF, CXCR3, CCR1
21nitric oxide46 25 1211.0CCR1, CXCR3, TNF
22heparin46 30 25 1211.8CFI, CXCR3, CCR1
23retinoic acid46 259.4CCR1, TNF, CFI
24serine468.4CCR1, CXCR3, TNF, CFI

GO Terms for genes affiliated with Aphthous Stomatitis

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17Gene Ontology
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Cellular components related to Aphthous Stomatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0CCR1, CXCR3, TNF

Biological processes related to Aphthous Stomatitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-positive bacteriumGO:0508309.8TNF, IL12A
2extrinsic apoptotic signaling pathwayGO:0971919.8IL12A, TNF
3positive regulation of interferon-gamma productionGO:0327299.8IL12A, TNF
4positive regulation of osteoclast differentiationGO:0456729.8CCR1, TNF
5calcium-mediated signalingGO:0197229.7TNF, CXCR3
6negative regulation of gene expressionGO:0106299.7CCR1, TNF
7positive regulation of ERK1 and ERK2 cascadeGO:0703749.6CCR1, TNF
8response to virusGO:0096159.5IL12A, TNF
9positive regulation of cytosolic calcium ion concentrationGO:0072049.4CXCR3, CCR1
10cell surface receptor signaling pathwayGO:0071669.4CCR1, CXCR3
11chemotaxisGO:0069359.1CCR1, CXCR3
12inflammatory responseGO:0069548.7CCR1, MEFV, CXCR3, TNF

Molecular functions related to Aphthous Stomatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.6IL12A, TNF
2chemokine receptor activityGO:0049509.1CCR1, CXCR3

Products for genes affiliated with Aphthous Stomatitis

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  • Antibodies
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  • Antibodies

Sources for Aphthous Stomatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet