MCID: APH001
MIFTS: 59

Aphthous Stomatitis malady

Oral diseases category

Summaries for Aphthous Stomatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Aphthous stomatitis (also termed canker sores,recurrent aphthous stomatitis, RAS, recurring oral aphthae... more...

MalaCards: Aphthous Stomatitis, also known as aphthous ulceration, is related to celiac disease and behcet's disease. An important gene associated with Aphthous Stomatitis is TNF (tumor necrosis factor), and among its related pathways are HTLV-I infection and Malaria. The drug thalidomide and the compounds indomethacin and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and t cells, and related mouse phenotypes are skeleton and reproductive system.

Aliases & Classifications for Aphthous Stomatitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

aphthous stomatitis 8 42 10 60
aphthous ulceration 8
oral aphthae 8
canker sore 8
aphtha 8


Related Diseases for Aphthous Stomatitis

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17GeneCards, 18GeneDecks
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Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1celiac disease30.7HLA-A
2behcet's disease30.7LTA, MEFV, HLA-A, TNF, CCR5
3herpes simplex30.5TKT, CD40, VDR
4lichen planus30.4CXCR3
5neutropenia30.4IL1RN, CD40
6glomerulonephritis30.4CFI, IL1B, IL1RN, CAT, CCR5
7tonsillitis30.2IL1A, LTA
8gingivitis30.2IL1B, IL1A
9pyoderma gangrenosum30.2MEFV, MVK
10familial mediterranean fever30.2MEFV, TNF
11smallpox30.2TKT, HLA-A
12encephalitis30.2IL1B, CAT, CCR5
13arthritis30.2IL1B, IL1A, TNF
14hepatitis30.2TKT, LTA, HLA-A, CAT
15periodontal disease30.2IL1B, IL1A, IL1RN, TNF
16hepatitis c30.2IL10, CXCR3, CD69, HLA-A, TNF, CCR5
17periodontitis30.2IL1B, IL1A, IL1RN, IL10, VDR, LTA
18multiple sclerosis30.2IL1B, IL1RN, IL10, CXCR3, CD69, CD40
19rheumatoid arthritis30.2CFI, TKT, IL1B, IL1A, IL1RN, IL10
20esophagitis30.1CAT
21myositis29.9IL1A, IL1RN
22stomatitis11.5
23pharyngitis11.0
24cervicitis10.8
25cervical adenitis10.8
26ulcerative stomatitis10.7
27periodic fever, aphthous stomatitis, pharyngitis and adenitis10.6
28adult syndrome10.4
29vitamin b12 deficiency10.3
30sutton disease 210.3
31mouth disease10.2
32burns10.1
33paronychia10.1
34bruxism10.1
35pityriasis rosea10.1
36burning mouth syndrome10.1
37proliferative glomerulonephritis10.1
38pericoronitis10.1
39fanconi syndrome10.1
40pemphigus10.1
41hypersplenism10.1
42pernicious anemia10.1
43hepatitis a10.1
44acute cervicitis10.1
45constipation10.1
46food allergy10.1
47laryngitis10.1
48leukocyte disease10.1
49pyoderma10.1
50thrombophlebitis10.1

Graphical network of the top 20 diseases related to Aphthous Stomatitis:



Diseases related to aphthous stomatitis

Clinical Features for Aphthous Stomatitis

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Drugs & Therapeutics for Aphthous Stomatitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Aphthous Stomatitis

Search CenterWatch for Aphthous Stomatitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Aphthous Stomatitis

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Anatomical Context for Aphthous Stomatitis

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32MalaCards
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MalaCards organs/tissues related to Aphthous Stomatitis:

32
Testes, Heart, T cells, Tonsil, Monocytes, Endothelial

Animal Models for Aphthous Stomatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Aphthous Stomatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.8MEFV, LTA, CD40, IL1B, NOS3
2MP:00053899.7IL1RN, VDR, MEFV, CCR5
3MP:00020069.7CCR5, TNF, CXCR3, IL10, IL1B
4MP:00053769.0CCR5, MEFV, LTA, VDR, CD40, CXCR3
5MP:00053708.8CCR5, TNF, MEFV, LTA, IL10, TKT
6MP:00053978.5LTA, MEFV, TNF, CCR5, VDR, CD40
7MP:00053858.5CCR5, TNF, LTA, VDR, CXCR3, IL10
8MP:00053848.3CCR5, CAT, TNF, MEFV, LTA, VDR
9MP:00053878.1NOS3, CCR5, TNF, MEFV, LTA, VDR
10MP:00107688.0LTA, MEFV, TNF, CAT, CCR5, VDR

Publications for Aphthous Stomatitis

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50PubMed
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Articles related to Aphthous Stomatitis:

(show top 50)    (show all 472)
idTitleAuthorsYear
1
Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects: Literature Review. (24217985)
2013
2
Recurrent aphthous stomatitis: genetic aspects of etiology. (24278055)
2013
3
Elevated serum IgE in recurrent aphthous stomatitis and associations with disease characteristics. (23730959)
2013
4
Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome and IgA nephropathy. (22940910)
2013
5
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)
2012
6
Periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis. (22759839)
2012
7
Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a randomized controlled clinical trial. (22435470)
2012
8
Inconclusive evidence on systemic treatments for recurrent aphthous stomatitis. (23258184)
2012
9
Does recurrent aphthous stomatitis affect quality of life? A prospective study with 128 patients evaluating different treatment modalities. (20804437)
2011
10
Urban legends: recurrent aphthous stomatitis. (21812866)
2011
11
Evaluation of Rosa damascena mouthwash in the treatment of recurrent aphthous stomatitis: a randomized, double-blinded, placebo-controlled clinical trial. (21519586)
2011
12
Occurrence of recurrent aphthous stomatitis only on lining mucosa and its relationship to smoking--a possible hypothesis. (21546167)
2011
13
Pilot study on recurrent aphthous stomatitis (RAS): a randomized placebo-controlled trial for the comparative therapeutic effects of systemic prednisone and systemic montelukast in subjects unresponsive to topical therapy. (19926502)
2010
14
Common occurrence of everolimus-associated aphthous stomatitis in Japanese heart transplant recipients. (21094841)
2010
15
Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome. (19209090)
2009
16
Oxidant/antioxidant status in recurrent aphthous stomatitis. (19761497)
2009
17
Comparison of the clinical features of recurrent aphthous stomatitis and BehAset's disease. (19549229)
2009
18
Recurrent aphthous stomatitis may be initiated by traumatic epithelial implantation and sustained by localized pathergic status. (17768013)
2008
19
Topical minocycline for managing symptoms of recurrent aphthous stomatitis. (18271771)
2008
20
The role of tonsillectomy in management of periodic fever, aphthous stomatitis, pharyngitis, and adenopathy: Unanswered questions. (18410792)
2008
21
The effect of bee propolis on recurrent aphthous stomatitis: a pilot study. (17285269)
2007
22
Is B12 vitamin deficiency really the cause of recurrent aphthous stomatitis? (17606052)
2007
23
Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over study. (17498420)
2007
24
Recurrent aphthous stomatitis revisited; clinical features, associations, and new association with infant feeding practices? (17944755)
2007
25
The assessment of oral health-related quality of life by factor analysis in patients with Behcet's disease and recurrent aphthous stomatitis. (17305636)
2007
26
Hematologic status in patients with recurrent aphthous stomatitis in Jordan. (16532102)
2006
27
Comparison of oral aphthae in BehAset's disease and idiopathic recurrent aphthous stomatitis. (12918713)
2003
28
Recurrent aphthous stomatitis. (12622266)
2003
29
Oxidant/antioxidant status in patients with recurrent aphthous stomatitis. (14616834)
2003
30
IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS). (12140751)
2002
31
Recurrent aphthous stomatitis. (11203919)
2000
32
Recurrent aphthous stomatitis and smoking. (10849126)
2000
33
PFAPA syndrome (Periodic Fever, Aphthous stomatitis, Pharyngitis, Adenitis). (11206345)
1999
34
An evaluation of a chemical cautery agent and an anti-inflammatory ointment for the treatment of recurrent aphthous stomatitis: a pilot study. (10196853)
1998
35
Serum IgG antibodies to Helicobacter pylori in patients with recurrent aphthous stomatitis and other oral disorders. (9084193)
1997
36
The association of menstrual cycle, pregnancy, and menopause with recurrent oral aphthous stomatitis: a review and critique. (1495706)
1992
37
Recurrent aphthous stomatitis and vitamin B12 deficiency. (2321075)
1990
38
Lack of effect of oral acyclovir on prevention of aphthous stomatitis. (3124046)
1988
39
Serum immunoglobulins in recurrent aphthous stomatitis. (3225646)
1988
40
Recurrent aphthous stomatitis. (3516474)
1986
41
Aphthous stomatitis with involvement of attached gingiva. (3862004)
1985
42
Therapeutic evaluation of levamisole in recurrent aphthous stomatitis. Double-blind comparison of two dosage schedules of levamisole and placebo. (6366166)
1983
43
Aphthous stomatitis: correlation with intestinal parasitosis. (6798244)
1981
44
Randomized, double-blind study of levamisole in recurrent aphthous stomatitis. (105101)
1978
45
Cell-mediated and humoral immunity against oral streptococci, neisseria, staphylococci, and adult human oral mucosa antigens in recurrent aphthous stomatitis. (345407)
1978
46
Therapeutic management of primary herpes, recurrent labial herpes, aphthous stomatitis, and Vincent's infection. (5272457)
1970
47
Recurrent aphthous stomatitis. Concepts in pathogenesis. (5905849)
1966
48
Steatorrhoea presenting as aphthous stomatitis. (5924587)
1966
49
Successful treatment of aphthous stomatitis. (13441064)
1957
50
Therapeutic study of aphthous stomatitis by means of purified vaccine lymph (PVL); preliminary report. (14397440)
1955

Genetic Variations for Aphthous Stomatitis

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Expression for genes affiliated with Aphthous Stomatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aphthous Stomatitis

Search GEO for disease gene expression data for Aphthous Stomatitis.

Pathways for genes affiliated with Aphthous Stomatitis

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Sources:
29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 52R&D Systems, 55SinoBiological
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Pathways related to Aphthous Stomatitis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD40
210.3CD40
3
Hide members
10.2IL12A, LTA
4
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10.1CCR5, IL1A
510.1IL1A, IL1B
6
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.1VDR, IL1A
710.0IL1B, IL12A, TNF
810.0IL1B, IL12A, TNF
9
Hide members
10.0IL10, IL12A, TNF
10
Hide members
10.0TNF, IL1B, MEFV
1110.0TNF, LTA, IL1A
1210.0IL1B, TNF, CAT
1310.0IL1A, IL1B, TNF
14
Hide members
9.9IL1B, IL1A, IL1RN
15
Hide members
9.9CCR5, LTA, CXCR3, IL12A
16
Hide members
9.9LTA, CCR5, IL12A, CXCR3
17
Hide members
9.8CCR5, IL12A, IL1A, CD40
189.8CD40, LTA, TNF, IL1B
199.8TNF, IL12A, IL1B, IL10
209.8IL10, IL1B, TNF, IL12A
21
Hide members
9.8IL1B, TNF, LTA, IL1A
22
Hide members
9.8LTA, IL1A, IL1B, TNF
23
Hide members
9.8TNF, CD40, HLA-A, LTA
24
Immune response Bacterial infections in normal airways
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9.8IL1A, TNF, IL1B, IL1RN
259.7IL1B, IL1A, TNF, IL10
26
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9.7IL1B, IL12A, HLA-A, CCR5
27
Development PDGF signaling via STATs and NF-kB
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9.7NOS3, TNF, IL10, IL1B
28
Hide members
9.7CCR5, IL12A, CXCR3, IL1A, CD40
29
Hide members
9.7TNF, LTA, IL12A, IL1B, IL1A
30
Hide members
9.7HLA-A, IL1RN, IL1B, IL1A
31
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9.6IL12A, IL1B, IL10, CD40, TNF
32
Hide members
9.6IL12A, IL1B, LTA, TNF, IL10
339.6IL10, IL1B, TNF, IL1A, IL12A
349.6IL1A, IL12A, IL10, VDR, TNF
359.6IL1RN, IL10, IL1B, TNF, IL1A
369.4TNF, IL1B, IL1A, IL12A, IL10, LTA
37
Hide members
9.4IL1B, HLA-A, TNF, LTA, IL12A, IL1A
38
Hide members
9.3HLA-A, MEFV, CD40, IL1RN, IL1B, IL1A
39
Hide members
9.0IL12A, LTA, TNF, IL1A, CD40, IL1B
40
Hide members
8.9IL12A, IL1A, IL1B, LTA, TNF, NOS3

Compounds for genes affiliated with Aphthous Stomatitis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Aphthous Stomatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.6NOS3
2endotoxin4410.6CXCR3, MEFV
3pentoxifylline44 1111.5IL1RN, LTA
4dexamethasone44 49 28 1113.5VDR, LTA
5manganese superoxide4410.3CAT, CD40
6cycloheximide4410.3LTA, CAT, TKT
7ivig4410.2IL1RN, CD40, CCR5, IL1A
8gm-csf44 2811.1IL10, TNF
9anakinra44 1111.1IL1B, IL1RN, TNF, MVK
10mip 1alpha4410.1TNF, IL10, CCR5, IL1B
11tacrolimus44 49 1112.0CD69, CXCR3, CD40, VDR
12pdtc4410.0IL1A, CAT, IL1B
13gold sodium thiomalate4410.0IL1RN, IL1A, TNF, IL1B
14toxin-14410.0LTA, IL10, IL1RN, IL1B, TNF
15vitamin d4410.0CCR5, IL10, VDR, LTA
16rantes449.9TNF, LTA, CD40, IL1A, IL1B, CXCR3
17tarc449.9IL1A, CCR5, IL10, TNF, CXCR3
18lipoteichoic acid449.9IL1RN, IL10, LTA, TNF, IL1B
19polyinosinic-polycytidylic acid449.9IL10, IL1A, CD40, IL1B, TNF
20polymyxin b449.9IL1B, TNF, IL10, IL1A, IL1RN
21cyclosporin a44 28 5911.9VDR, LTA, HLA-A, CD40, CD69
22l-nmma449.9TNF, CAT, IL1B, NOS3, IL1RN
23groalpha449.9IL1B, IL1A, IL10, CXCR3, TNF, CCR5
24etanercept44 49 1111.8IL1RN, IL1B, IL10, CXCR3, LTA, TNF
25fmlp449.8CXCR3, IL1RN, CD69, IL1A, TKT
26infliximab44 49 1111.8IL10, TNF, IL1RN, CXCR3, LTA, IL1B
27ccl344 2810.8CCR5, CXCR3, IL10, IL1B, IL1A, TNF
28superoxide44 2410.7CXCR3, IL1B, TNF, NOS3, CD40
29sulfasalazine44 28 49 1112.7IL1RN, TNF, IL1B, IL1A
30allergens449.7IL1RN, IL10, CXCR3, CD69, CD40
31neopterin449.7IL1A, CD40, TNF, LTA, IL1B, IL10
32ionomycin449.6IL1A, LTA, TNF, CD40, CD69, IL10
33calcitriol44 59 11 2412.6IL1B, LTA, CFI, IL1A, IL10, VDR
34histamine44 28 2411.5TNF, IL1RN, IL10, CXCR3, CD40, IL1B
35simvastatin44 49 59 28 11 2414.5IL1A, TNF, NOS3, IL10, CD40, MVK
36herbimycin a44 5910.5TNF, LTA, CD40, CD69, IL1A, IL1B
37ly294002449.3IL10, CXCR3, NOS3, CD69, TNF, IL1B
38serine449.3VDR, LTA, MVK, CCR5, CD69, CXCR3
39atorvastatin44 49 28 11 2413.3IL1RN, TNF, CD40, IL10, NOS3
40creatinine449.3CXCR3, CD69, VDR, IL1RN, IL1A, CFI
41methotrexate44 49 1111.2IL1B, IL1RN, IL10, CD69, TKT, TNF
42sb 20358044 5910.2CAT, IL1A, IL1B, NOS3, CD40, VDR
43ascorbic acid44 2410.2IL1RN, NOS3, CAT, VDR, TKT, IL1A
44genistein44 28 59 2 11 2414.1NOS3, TNF, TKT, VDR, CD40, CD69
45il 10449.1IL10, CCR5, LTA, VDR, CD40, CXCR3
46thymidine44 2410.0IL1B, TKT, VDR, IL10, CXCR3, IL1A
47actinomycin d449.0IL1A, IL1B, CD69, NOS3, CD40, VDR
48vegf448.9NOS3, TKT, CD40, IL1RN, IL1B, IL10
49nitric oxide44 11 2410.8CXCR3, IL10, NOS3, IL1B, IL1A, IL1RN
50retinoic acid44 249.8NOS3, TNF, CCR5, VDR, LTA, CD40

GO Terms for genes affiliated with Aphthous Stomatitis

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16Gene Ontology
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Cellular components related to Aphthous Stomatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6CXCR3, CD69, CD40, TNF, CCR5
2extracellular spaceGO:0056158.5CFI, TNF, FAP, LTA, IL10, IL12A

Biological processes related to Aphthous Stomatitis according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.6TNF, LTA
2chronic inflammatory response to antigenic stimulusGO:00243910.5TNF, IL1RN
3positive regulation of calcidiol 1-monooxygenase activityGO:06055910.5TNF, IL1B
4sequestering of triglycerideGO:03073010.5TNF, IL1B
5receptor biosynthetic processGO:03280010.5TNF, IL10
6regulation of immunoglobulin secretionGO:05102310.5TNF, CD40
7positive regulation of heterotypic cell-cell adhesionGO:03411610.5IL1B, TNF
8fever generationGO:00166010.5IL1A, IL1B
9positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.4LTA, TNF
10positive regulation of fever generationGO:03162210.4TNF, IL1B
11defense response to Gram-positive bacteriumGO:05083010.4TNF, LTA, IL12A
12negative regulation of cytokine secretion involved in immune responseGO:00274010.4TNF, IL10
13negative regulation of growth of symbiont in hostGO:04413010.4IL10, LTA, TNF
14calcium-mediated signalingGO:01972210.4CXCR3, TNF, CCR5
15negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.4TNF, IL1A, IL1B
16positive regulation of chemokine biosynthetic processGO:04508010.3IL1B, TNF
17positive regulation of mitosisGO:04584010.3TNF, IL1A, IL1B
18positive regulation of cytokine secretionGO:05071510.3IL1A, IL10, TNF
19lipopolysaccharide-mediated signaling pathwayGO:03166310.3TNF, IL1B, NOS3
20regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.3IL1B, TNF
21positive regulation of interferon-gamma productionGO:03272910.3TNF, LTA, IL12A, IL1B
22positive regulation of cell divisionGO:05178110.2CAT, IL1A, IL1B
23MAPK cascadeGO:00016510.2IL1B, TNF, CCR5
24positive regulation of NF-kappaB transcription factor activityGO:05109210.2CAT, TNF, CD40, IL1B
25response to glucocorticoid stimulusGO:05138410.2TNF, IL10, IL1RN
26B cell proliferationGO:04210010.1IL10, CD40
27positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.1IL1B, IL10, TNF
28positive regulation of protein phosphorylationGO:00193410.0IL1B, CD40, TNF
29positive regulation of angiogenesisGO:0457669.9IL1A, IL1B, NOS3
30cell-cell signalingGO:0072679.9CCR5, LTA, IL10, IL1B
31negative regulation of cell proliferationGO:0082859.8TNF, VDR, IL1A, IL1B, NOS3
32negative regulation of interleukin-12 productionGO:0326959.8IL10, MEFV
33immune responseGO:0069559.7CCR5, HLA-A, IL12A, IL1RN, IL1A, IL1B
34response to drugGO:0424939.7TNF, LTA, IL10, IL1RN
35positive regulation of transcription from RNA polymerase II promoterGO:0459449.7TNF, VDR, CD40, IL10, IL1A, IL1B
36inflammatory responseGO:0069549.5IL1B, CCR5, TNF, MEFV, CD40, CXCR3

Molecular functions related to Aphthous Stomatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.9IL1B, IL1A, IL1RN
2cytokine activityGO:0051259.1IL1B, IL1A, IL12A, IL10, LTA, TNF

Products for genes affiliated with Aphthous Stomatitis

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  • Antibodies
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Sources for Aphthous Stomatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet