MCID: APH001
MIFTS: 58

Aphthous Stomatitis

Categories: Rare diseases, Oral diseases

Aliases & Classifications for Aphthous Stomatitis

MalaCards integrated aliases for Aphthous Stomatitis:

Name: Aphthous Stomatitis 12 50 14 69
Oral Ulcer 12 29 52 69
Minor Oral Aphthous Ulceration 69
Stomatitis, Aphthous 42
Aphthous Ulceration 12
Oral Aphthous Ulcer 12
Oral Aphthae 12
Canker Sores 41
Canker Sore 12
Aphtha 12

Classifications:



Summaries for Aphthous Stomatitis

MedlinePlus : 41 canker sores are small, round sores in your mouth. they can be on the inside of your cheek, under your tongue, or in the back of your throat. they usually have a red edge and a gray center. they can be quite painful. they are not the same as cold sores, which are caused by herpes simplex. canker sores aren't contagious. they may happen if you have a viral infection. they may also be triggered by stress, food allergies, lack of vitamins and minerals, hormonal changes or menstrual periods. in some cases the cause is unknown. in most cases, the sores go away by themselves. some ointments, creams or rinses may help with the pain. avoiding hot, spicy food while you have a canker sore also helps.

MalaCards based summary : Aphthous Stomatitis, also known as oral ulcer, is related to rheumatoid arthritis and periodic fever, aphthous stomatitis, pharyngitis and adenitis, and has symptoms including halitosis, snoring and enanthema. An important gene associated with Aphthous Stomatitis is MEFV (MEFV, Pyrin Innate Immunity Regulator), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and neutrophil, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Disease Ontology : 12 A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers.

Wikipedia : 72 Aphthous stomatitis is a common condition characterized by the repeated formation of benign and... more...

Related Diseases for Aphthous Stomatitis

Diseases related to Aphthous Stomatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 328)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 28.0 HLA-B IL10 IL1B IL1RN IL4 IL6
2 periodic fever, aphthous stomatitis, pharyngitis and adenitis 12.5
3 sutton disease 2 11.8
4 stomatitis 11.2
5 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
6 pure autonomic failure 10.8 IL10 TNF
7 aortic arch interruption 10.8 IL6 TNF
8 cutaneous leishmaniasis 10.8 IL6 TNF
9 sternal cleft 10.8 IL1B TNF
10 oculomotor nerve paralysis 10.8 IL1B IL6
11 common peroneal nerve lesion 10.8 IL1B IL6
12 spirillary rat-bite fever 10.7 IL6 TNF
13 toxoplasmosis 10.7 IL6 TNF
14 pulmonary hypertension 10.7 IL1B TNF
15 multiple familial trichoepithelioma 10.7 IL10 TNF
16 craniometaphyseal dysplasia 10.7 MEFV TNF
17 pharyngitis 10.7
18 dyslexia 5 10.7 IL6 TNF
19 type 1 papillary adenoma of the kidney 10.7 IL10 TNF
20 peroneal nerve paralysis 10.7 IL10 IL6
21 drug rash with eosinophilia and systemic symptoms 10.7 IL10 IL6
22 epstein-barr virus hepatitis 10.7 IL6 TNF
23 endosalpingiosis 10.7 IL10 TNF
24 cataract 10.7 IL1B TNF
25 anencephaly and spina bifida x-linked 10.7 IL6 TNF
26 eye accommodation disease 10.7 IL10 IL4
27 papilledema 10.6 IL6 TNF
28 ileitis 10.6 IL1B IL4
29 idiopathic dilatation of the pulmonary artery 10.6 IL10 TNF
30 x-linked dominant intellectual disability-epilepsy syndrome 10.6 IL1B IL6
31 diabetic angiopathy 10.6 IL10 IL4
32 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.6 IL1B TNF
33 tarsal tunnel syndrome 10.6 IL10 TNF
34 ptosis coloboma mental retardation 10.6 MEFV NLRP3
35 cervicitis 10.6
36 ciliary body cancer 10.6 IL1B NLRP3
37 thelaziasis 10.6 IL10 IL4
38 scrotal carcinoma 10.6 IL1B IL6 TNF
39 upper gum cancer 10.6 IL1B IL6 TNF
40 bipolar i disorder 10.6 IL1B IL6 TNF
41 cervical adenitis 10.6
42 tinea favosa 10.6 IL1B IL6 TNF
43 central nervous system leiomyosarcoma 10.6 IL1B IL6 TNF
44 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.6 IL1B IL6 TNF
45 shoulder impingement syndrome 10.6 IL1RN IL6
46 psychotic disorder 10.6 IL4 IL6
47 deafness, autosomal recessive 22 10.6 IL10 IL4
48 gastric cancer risk after h. pylori infection 10.6 IL1B IL1RN
49 acquired thrombocytopenia 10.6 IL1B IL6 TNF
50 urethral intrinsic sphincter deficiency 10.6 IL4 TNF

Graphical network of the top 20 diseases related to Aphthous Stomatitis:



Diseases related to Aphthous Stomatitis

Symptoms & Phenotypes for Aphthous Stomatitis

UMLS symptoms related to Aphthous Stomatitis:


halitosis, snoring, enanthema, oral manifestations, oral mucosal blisters, sore mouth

GenomeRNAi Phenotypes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.75 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.75 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.75 HLA-B HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.75 HLA-B HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.75 HLA-A HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.75 MUC7
7 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.75 MUC7
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.75 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.75 MUC7
10 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.75 MUC7
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.75 MUC7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.75 MUC7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.75 MUC7
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.75 MUC7
15 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.75 MUC7 HLA-A HLA-B
16 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.75 HLA-B HLA-A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.75 HLA-B HLA-A

MGI Mouse Phenotypes related to Aphthous Stomatitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 IL10 IL1B IL1RN IL4 IL6 MEFV
2 immune system MP:0005387 9.92 IL6 MEFV NLRP3 TNF IL10 IL1B
3 integument MP:0010771 9.86 IL10 IL1B IL1RN IL4 IL6 MEFV
4 liver/biliary system MP:0005370 9.63 IL10 IL4 IL6 MEFV NLRP3 TNF
5 reproductive system MP:0005389 9.5 IL10 IL1RN IL4 IL6 MEFV NLRP3
6 skeleton MP:0005390 9.23 MEFV NLRP3 TNF IL10 IL1B IL1RN

Drugs & Therapeutics for Aphthous Stomatitis

Drugs for Aphthous Stomatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 120)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Early Phase 1 50-02-2 5743
2
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
3
Ethanol Approved Phase 3 64-17-5 702
4
Glycerol Approved, Investigational Phase 3 56-81-5 753
5
Menthol Approved Phase 3 2216-51-5 16666
6
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
7
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
8
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
9 Anti-Bacterial Agents Phase 3,Phase 2
10 Antiemetics Phase 3,Phase 2,Early Phase 1
11 Anti-Infective Agents Phase 3,Phase 2
12 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
13 Antineoplastic Agents, Hormonal Phase 3,Phase 2
14 Autonomic Agents Phase 3,Phase 2,Early Phase 1
15 BB 1101 Phase 3,Early Phase 1
16 Dexamethasone acetate Phase 3,Early Phase 1 1177-87-3
17 Gastrointestinal Agents Phase 3,Phase 2,Early Phase 1
18 glucocorticoids Phase 3,Phase 2
19 HIV Protease Inhibitors Phase 3
20 Hormone Antagonists Phase 3,Phase 2
21 Hormones Phase 3,Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
23 Peripheral Nervous System Agents Phase 3,Phase 2,Early Phase 1
24
protease inhibitors Phase 3
25 Micronutrients Phase 3,Phase 2
26 Retinol palmitate Phase 3
27 Trace Elements Phase 3,Phase 2
28 Vitamins Phase 3
29 Anesthetics Phase 3,Phase 2,Early Phase 1
30 Anesthetics, Local Phase 3,Phase 2,Early Phase 1
31 Antacids Phase 3
32 Anti-Ulcer Agents Phase 3
33
Bismuth Phase 3 7440-69-9 16682734 105143
34 Central Nervous System Depressants Phase 3,Phase 2,Early Phase 1
35 Calcium, Dietary Phase 3
36 Pharmaceutical Solutions Phase 3
37 retinol Nutraceutical Phase 3
38
Colchicine Approved Phase 2 64-86-8 6167 2833
39
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
40
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
41
Zinc Approved Phase 2,Early Phase 1 7440-66-6 32051 23994
42 Zinc sulfate Approved Phase 2 7733-02-0
43
Diphenhydramine Approved Phase 2,Early Phase 1 58-73-1, 147-24-0 3100
44
Histamine Approved, Investigational Phase 2,Early Phase 1 75614-87-8, 51-45-6 774
45
Ibuprofen Approved Phase 2 15687-27-1 3672
46
Promethazine Approved Phase 2,Early Phase 1 60-87-7 4927
47
Betamethasone Approved, Vet_approved Phase 2 378-44-9 9782
48 Antimitotic Agents Phase 2
49 Antirheumatic Agents Phase 2,Phase 1
50 Methylprednisolone acetate Phase 2

Interventional clinical trials:

(show all 40)

id Name Status NCT ID Phase Drugs
1 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
2 Prevention of Recurrent Aphthous Stomatitis Using Vitamins Completed NCT00527306 Phase 3
3 Efficacy of the Combination Bismuth + Neomycin + Procaine in the Treatment of Recurrent Aphthous Ulceration Completed NCT00857688 Phase 3 Bismu-Jet
4 Caphosol in Oral Mucositis Due to Targeted Therapy Completed NCT01265810 Phase 3
5 Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients Unknown status NCT01831453 Phase 2 omega-3;placebo
6 Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae Unknown status NCT00723268 Phase 2 Prednisolone;Colchicine
7 Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study Completed NCT01210014 Phase 2 zinc sulphate 220mg/day in one dosage;placebo: one dosage
8 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis Completed NCT01293968 Phase 2 Ibuprofen, Diphenhydramine and Aluminium MgS;Diphenhydramine and Aluminium MgS
9 Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis Completed NCT01652625 Phase 2 Yunnan Baiyao toothpaste;Placebo toothpaste
10 Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection Completed NCT00000790 Phase 2 Thalidomide
11 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
12 Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's Disease Completed NCT00700297 Phase 2 Colchicine;Placebo
13 Anakinra for Behcet s Disease Completed NCT01441076 Phase 1, Phase 2 Anakinra
14 Thalidomide to Treat Oral Lesions in HIV-Infected Patients Completed NCT00001524 Phase 2 Thalidomide
15 Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis Not yet recruiting NCT02789605 Phase 2 Bacilor;Placebo
16 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Not yet recruiting NCT02535962 Phase 2
17 Efficacy of Adhesive Tablets in Treating Oral Ulcers (Aphthous) Suspended NCT00281723 Phase 2 Pro-Pe adhesive tablet
18 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease Terminated NCT00792740 Phase 1, Phase 2 ITF2357;Placebo capsules
19 Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis Terminated NCT00075023 Phase 2 Thalidomide Gel;Placebo Gel
20 Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae Completed NCT01122147 Phase 1 chamomilla tincture mouthwash;placebo mouthwash
21 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Not yet recruiting NCT02775994 Phase 1 Canakinumab
22 Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis Completed NCT01501409
23 Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis Completed NCT00288769 daily sublingual tablets Vitamin B12 1000 mcg versus placebo
24 Treatment of Recurrent Aphthous Stomatitis With Er,Cr:YSGG Laser Irradiation Completed NCT02925182
25 The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer Completed NCT02142543 Early Phase 1 2-DeNT powder;Placebo Comparator
26 A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis Completed NCT00315679 Pentoxifylline (also known as oxpentifylline)
27 Abdominal Ultrasound Examination in Non-celiac Wheat Sensitivity Completed NCT03017274
28 Evaluation and Treatment of Oral Soft Tissue Diseases Completed NCT00001601
29 The Vienna RAP Pilot Study Completed NCT01632605 Sirolimus
30 Tokushima Night Guard for Recurrent Aphthous Stomatitis Recruiting NCT02890524 Early Phase 1
31 The Salivary and Faecal Microbiome of Recurrent Aphthous Stomatitis Patients Before and After Treatment With Probiotics Recruiting NCT02976922
32 Gynaecological Disorders in Not-celiac Wheat Sensitivity Recruiting NCT03027492
33 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients Recruiting NCT03008252
34 Salivary Cytokines as Biomarker for Oral Health Recruiting NCT02807519
35 Identification of Viruses Associated With Diseases of Unknown Cause Enrolling by invitation NCT00359268
36 Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer Not yet recruiting NCT03213769 topical coenzyme Q10 gel;Carpabol gel
37 Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients Not yet recruiting NCT03022513
38 The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus Not yet recruiting NCT03052179
39 Influence of Different Doses of the Vitamin B12 on Recurrent Aphthous Stomatitis Terminated NCT01127724 vitamin B12 treatment
40 Salivary Catecholamines in Aphthous Stomatitis (Canker Sores) Withdrawn NCT00556686

Search NIH Clinical Center for Aphthous Stomatitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: stomatitis, aphthous

Genetic Tests for Aphthous Stomatitis

Genetic tests related to Aphthous Stomatitis:

id Genetic test Affiliating Genes
1 Oral Ulcer 29

Anatomical Context for Aphthous Stomatitis

MalaCards organs/tissues related to Aphthous Stomatitis:

39
Tongue, Testes, Neutrophil, Liver, T Cells, Tonsil, Heart

Publications for Aphthous Stomatitis

Articles related to Aphthous Stomatitis:

(show top 50) (show all 601)
id Title Authors Year
1
Recurrent Aphthous Stomatitis: A Review. ( 28360966 )
2017
2
Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis. ( 28543912 )
2017
3
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children. ( 28343210 )
2017
4
INFLUENCE OF OZONE THERAPY ON ORAL TISSUE IN MODELING OF CHRONIC RECURRENT APHTHOUS STOMATITIS. ( 28480862 )
2017
5
Enzymatic antioxidants status in patients with recurrent aphthous stomatitis. ( 28054386 )
2017
6
Unraveling the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis through genetic, immunologic, and microbiologic discoveries: an update. ( 28557837 )
2017
7
Evolving Frontiers in the Treatment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Syndrome. ( 28786261 )
2017
8
Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28748511 )
2017
9
Salivary Alpha-Amylase Enzyme, Psychological Disorders, and Life Quality in Patients with Recurrent Aphthous Stomatitis. ( 28408928 )
2017
10
Efficacy and safety of Chinese patent medicines in the treatment ofA recurrent aphthous stomatitis: A systematic review. ( 28062049 )
2017
11
Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis. ( 28839413 )
2017
12
Letter regarding "Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review". ( 28801870 )
2017
13
Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome. ( 28137891 )
2017
14
Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis. ( 28922104 )
2017
15
Stress as a Cause of Recurrent Aphthous Stomatitis and Its Correlation with Salivary Stress Markers. ( 28847142 )
2017
16
Apremilast for treatment of recalcitrant aphthous stomatitis. ( 28884141 )
2017
17
Aphthous Stomatitis ( 28613713 )
2017
18
Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis. ( 27793414 )
2017
19
Enamel defects and aphthous stomatitis in celiac and healthy subjects: Systematic review and meta-analysis of controlled studies. ( 28688949 )
2017
20
The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oralA rinse. ( 28411006 )
2017
21
Assessment of Oxidant-Antioxidant Status and Stress Factor in Recurrent Aphthous Stomatitis Patients: Case Control Study. ( 28511497 )
2017
22
Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis. ( 27875792 )
2017
23
Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28271158 )
2017
24
Patient-reported outcome measures in recurrent aphthous stomatitis: A critical assessment of quality properties. ( 28779517 )
2017
25
Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants? ( 28207965 )
2017
26
The absence of an association between Interleukin 1I^ gene polymorphisms and recurrent aphthous stomatitis (RAS). ( 28942153 )
2017
27
INTERMEDIATE UVEITIS ASSOCIATED WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND CERVICAL ADENITIS SYNDROME. ( 28570435 )
2017
28
Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic. ( 28776757 )
2017
29
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis. ( 26984802 )
2016
30
Recurrent aphthous stomatitis. ( 27343962 )
2016
31
Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis. ( 26943669 )
2016
32
Hypofunction of the Sympathetic Nervous System as a Possible Etiologic Cause of Recurrent Aphthous Stomatitis. ( 27517475 )
2016
33
Recurrent aphthous stomatitis and Helicobacter pylori. ( 26827061 )
2016
34
Effectiveness of Laser Therapy in the Management of Recurrent Aphthous Stomatitis: A Systematic Review. ( 28078164 )
2016
35
HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis. ( 27921409 )
2016
36
Efficacy and safety of topical herbal medicine treatment on recurrent aphthous stomatitis: a systemic review. ( 26770058 )
2016
37
The safety and efficacy of AphtoFixAr mouth ulcer cream in the management of recurrent aphthous stomatitis. ( 26868504 )
2016
38
Investigation of BehAset's Disease and Recurrent Aphthous Stomatitis Frequency: The Highest Prevalence in Turkey. ( 27606133 )
2016
39
Efficacy of Omega-3 in Treatment of Recurrent Aphthous Stomatitis: A Randomised, Double-blind, Placebo-controlled Study. ( 27622219 )
2016
40
Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive and -negative recurrent aphthous stomatitis patients with anti-thyroid antibody positivity. ( 27825814 )
2016
41
Guidelines for the management and treatment of periodic fever syndromes: periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome. ( 27267334 )
2016
42
Status of Neutrophils, Lymphocytes and Platelets in Patients with Recurrent Aphthous Stomatitis: A Retrospective Study. ( 28008393 )
2016
43
Tonsillar microbiota in children with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) syndrome. ( 27025724 )
2016
44
Total antioxidant status and oxidative stress in recurrent aphthous stomatitis. ( 26625952 )
2016
45
Lack of Association between Interleukin-12 Gene Polymorphisms and Recurrent Aphthous Stomatitis. ( 27920889 )
2016
46
Mucosal and salivary microbiota associated with recurrent aphthous stomatitis. ( 27036492 )
2016
47
Is Optimal Management of Recurrent Aphthous Stomatitis Possible? A Reality Check. ( 27891490 )
2016
48
A comparison of the effect of triamcinolone ointment and mouthwash with or without zinc on the healing process of aphthous stomatitis lesions. ( 27429724 )
2016
49
Family History in Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. ( 27565549 )
2016
50
Clinical phenotype of recurrent aphthous stomatitis and interleukin-1I^ genotype in a Polish cohort of patients. ( 27935125 )
2016

Variations for Aphthous Stomatitis

Expression for Aphthous Stomatitis

Search GEO for disease gene expression data for Aphthous Stomatitis.

Pathways for Aphthous Stomatitis

Pathways related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 HLA-A HLA-B IL10 IL1B IL1RN IL4
2
Show member pathways
13.29 HLA-A HLA-B IL10 IL1B IL1RN IL4
3
Show member pathways
12.95 IL1B IL1RN IL6 MEFV NLRP3 TNF
4
Show member pathways
12.79 IL10 IL1B IL6 TNF
5
Show member pathways
12.65 HLA-A HLA-B IL10 IL1B IL4 IL6
6 12.61 HLA-A HLA-B IL4 IL6 TNF
7
Show member pathways
12.58 IL10 IL1B IL4 IL6 TNF
8
Show member pathways
12.56 HLA-A HLA-B IL1B IL4 IL6 NLRP3
9
Show member pathways
12.53 IL10 IL1B IL6 TNF
10 12.52 IL10 IL1B IL1RN IL4 TNF
11
Show member pathways
12.47 HLA-A HLA-B IL4 TNF
12
Show member pathways
12.41 IL10 IL1B IL4 IL6 TNF
13 12.39 HLA-A HLA-B IL6 TNF
14
Show member pathways
12.31 IL1B IL4 IL6 TNF
15
Show member pathways
12.24 IL10 IL1B IL4 TNF
16 12.22 IL10 IL1B IL6 TNF
17
Show member pathways
12.17 IL1B IL4 IL6 TNF
18 12.12 IL10 IL1B IL1RN IL6 TNF
19 12.01 IL1B IL4 IL6 TNF
20 11.99 IL10 IL4 IL6 TNF
21
Show member pathways
11.95 IL10 IL1B IL6 TNF
22
Show member pathways
11.93 HLA-A IL1B IL4
23 11.91 IL1B IL6 TNF
24 11.9 IL1B IL4 IL6 TNF
25 11.89 IL10 IL1B IL6 TNF
26 11.89 IL10 IL1B IL4 IL6 TNF
27
Show member pathways
11.87 IL1B IL4 IL6
28 11.86 IL1B IL6 TNF
29 11.82 IL1B IL6 TNF
30 11.8 IL10 IL1B IL4 TNF
31 11.77 IL10 IL1B IL6 TNF
32 11.71 IL10 IL4 IL6 TNF
33
Show member pathways
11.71 HLA-A HLA-B IL10 IL1B IL4 IL6
34
Show member pathways
11.65 IL1B IL6 TNF
35 11.64 IL1B IL4 IL6 TNF
36 11.59 IL1B IL6 TNF
37 11.54 IL10 IL1B IL6 NLRP3 TNF
38 11.49 IL1B IL6 TNF
39 11.49 IL10 IL1B IL6 TNF
40 11.44 IL1B MEFV NLRP3
41 11.32 IL10 IL1B IL6 TNF
42 11.31 IL1B IL6 TNF
43 11.3 IL10 IL1B IL6 TNF
44 11.21 IL1B IL4 IL6 TNF
45 11.15 IL10 IL1B IL4 IL6 TNF
46 11.05 IL1B TNF
47 11.05 IL6 TNF
48 11.03 IL10 IL1B IL4 IL6 TNF
49 10.98 IL6 TNF
50 10.91 IL1B TNF

GO Terms for Aphthous Stomatitis

Cellular components related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 IL10 IL1B IL1RN IL4 IL6 MUC7
2 MHC class I protein complex GO:0042612 8.96 HLA-A HLA-B

Biological processes related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

(show all 48)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.85 IL10 MEFV NLRP3
2 positive regulation of T cell proliferation GO:0042102 9.8 IL1B IL4 IL6
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 IL1B IL6 NLRP3 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.73 IL10 IL6 NLRP3 TNF
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.7 IL10 TNF
6 positive regulation of NF-kappaB import into nucleus GO:0042346 9.7 IL1B TNF
7 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
8 negative regulation of nitric oxide biosynthetic process GO:0045019 9.7 IL10 IL4
9 positive regulation of interleukin-6 production GO:0032755 9.7 IL1B IL6 TNF
10 positive regulation of chemokine production GO:0032722 9.69 IL6 TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 IL1B IL6 TNF
14 cellular response to hepatocyte growth factor stimulus GO:0035729 9.68 IL10 IL6
15 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
16 negative regulation of interleukin-12 production GO:0032695 9.68 IL10 MEFV
17 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.67 IL10 IL1RN
18 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
19 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.67 HLA-A HLA-B
20 response to glucocorticoid GO:0051384 9.67 IL10 IL1RN IL6 TNF
21 negative regulation of acute inflammatory response GO:0002674 9.66 IL4 NLRP3
22 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
23 positive regulation of interleukin-13 production GO:0032736 9.65 IL4 NLRP3
24 positive regulation of T-helper 2 cell differentiation GO:0045630 9.65 IL6 NLRP3
25 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 IL4
26 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
28 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.62 IL6 TNF
29 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.61 IL6 NLRP3
30 type 2 immune response GO:0042092 9.61 IL10 IL4
31 protection from natural killer cell mediated cytotoxicity GO:0042270 9.6 HLA-A HLA-B
32 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
33 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
34 defense response to protozoan GO:0042832 9.58 IL10 IL4 IL6
35 interleukin-1 beta production GO:0032611 9.57 IL1B NLRP3
36 regulation of isotype switching GO:0045191 9.56 IL10 IL4
37 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.55 IL1RN IL6
38 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.55 IL10 IL1B IL4 IL6 TNF
39 positive regulation of mononuclear cell migration GO:0071677 9.54 IL4 TNF
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.5 IL10 IL1B TNF
41 inflammatory response GO:0006954 9.5 IL10 IL1B IL1RN IL6 MEFV NLRP3
42 receptor biosynthetic process GO:0032800 9.49 IL10 TNF
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IL1B TNF
44 positive regulation of chemokine biosynthetic process GO:0045080 9.43 IL1B IL4 TNF
45 fever generation GO:0001660 9.29 IL1B
46 immune response GO:0006955 9.23 HLA-A HLA-B IL10 IL1B IL1RN IL4
47 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.11 IL10 IL1B IL4 IL6 NLRP3 TNF
48 positive regulation of transcription, DNA-templated GO:0045893 10.06 IL10 IL1B IL4 IL6 TNF

Molecular functions related to Aphthous Stomatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 IL10 IL1B IL1RN IL4 IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1RN

Sources for Aphthous Stomatitis

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