MCID: APL001
MIFTS: 83

Aplastic Anemia malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases, Bone diseases categories
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Summaries for Aplastic Anemia

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MedlinePlus:33 Aplastic anemia is a rare but serious blood disorder. if you have it, your bone marrow doesn't make enough new blood cells. causes include being exposed to toxic substances, such as pesticides, arsenic, and benzene radiation therapy and chemotherapy for cancer certain medicines infections such as hepatitis, epstein-barr virus, or hiv autoimmune disorders certain inherited conditions in many people, the cause is unknown. your doctor will diagnose aplastic anemia based on your medical and family histories, a physical exam, and test results. once your doctor knows the cause and severity of the condition, he or she can create a treatment plan for you. treatments include blood transfusions, blood and marrow stem cell transplants, and medicines. nih: national heart, lung, and blood institute

MalaCards based summary: Aplastic Anemia, also known as anemia aplastic, is related to dyskeratosis congenita and myelodysplastic syndromes, and has symptoms including An important gene associated with Aplastic Anemia is IFNG (interferon, gamma), and among its related pathways are Immune response IL 12 signaling pathway and Telomere Extension By Telomerase. The drug carboplatin and the compounds tin(2+) and daniplestim have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Disease Ontology:8 An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.

NIH Rare Diseases:42 Aplastic anemia is failure of the bone marrow to make enough blood cells. all blood cell types are affected. it can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. when the cause is unknown, it is referred to as idiopathic aplastic anemia. in about half of all cases, no cause can be found. the condition can be acute or chronic. last updated: 8/21/2009

Wikipedia:65 Aplastic anemia (AA) is a disease in which the bone marrow, and the blood stem cells that reside there,... more...

Descriptions from OMIM:46 609135,614742,614743

Aliases & Classifications for Aplastic Anemia

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 33MedlinePlus, 62UMLS, 22GTR, 44Novoseek, 48Orphanet, 34MeSH, 57SNOMED-CT, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Aplastic Anemia, Aliases & Descriptions:

Name: Aplastic Anemia 30 8 9 42 46 10 33 62
Anemia Aplastic 42 22 44
Idiopathic Aplastic Anemia 42 48
Bone Marrow Diseases 33 62
Bone Marrow Failure 48 62
 
Aplastic Anemia, Idiopathic 62
Secondary Aplastic Anaemia 62
Aplastic Anemia Idiopathic 42
Secondary Aplastic Anemia 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
idiopathic aplastic anemia:
Prevalence: 1-9/1000000; Age of onset: Adulthood; Age of death: Adult


External Ids:

Disease Ontology8 DOID:12449
MeSH34 D000741
ICD9CM27 284.9
NCIt39 C2870
MESH via Orphanet35 C538494
ICD10 via Orphanet26 D61.0
UMLS via Orphanet63 C0348890

Related Diseases for Aplastic Anemia

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Diseases in the Aplastic Anemia family:

Aplastic Anemia, Ifng-Related

Diseases related to Aplastic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1dyskeratosis congenita31.6DKC1, TERC
2myelodysplastic syndromes31.5TERC, PIGA, FLT3LG, EPO, IL3, CSF2
3refractory anemia31.4KITLG, CSF3, CSF2, IL3, EPO
4myeloid leukemia31.2KITLG, CSF3, CSF2, IL3
5graft versus host disease31.2IFNG, IL3, CSF2, CSF3
6diamond-blackfan anemia31.1EPO, IL3
7pancytopenia31.0EPO, DKC1, IL3, CSF2, CSF3
8neutropenia30.9EPO, IL3, SBDS, CSF2, CSF3, KITLG
9transient erythroblastopenia of childhood30.8EPO, KITLG
10severe congenital neutropenia autosomal recessive 330.8IL3, CSF2, CSF3
11felty's syndrome30.8IL3, CSF2, CSF3
12myelofibrosis30.8IL3, EPO
13erythrocytosis30.7KITLG, IL3, EPO
14thrombocytopenia30.7PIGA, FLT3LG, EPO, IL3, CSF2, CSF3
15severe congenital neutropenia30.7IL3, CSF2, CSF3, KITLG
16fanconi's anemia30.7TERC, NBN, DKC1, IL3, KITLG
17leukopenia30.6CD52, CSF3, CSF2, IL3, FLT3LG
18acute lymphoblastic leukemia30.5NBN, IL3, CSF2, CSF3, KITLG
19chronic myeloid leukemia30.5EPO, IL3, CSF2, CSF3, KITLG
20myeloma30.5EPO, IL3, CSF2, CSF3, KITLG
21hodgkin's lymphoma30.5CSF3, CSF2, IL3
22deficiency anemia30.4TERC, PIGA, EPO, IL3, CSF2, CSF3
23leukemia30.3FLT3LG, NBN, PIGA, TERC, TERT, EPO
24acute leukemia29.9TERT, TERC, FLT3LG, EPO, IL3, CSF2
25melanoma29.4TERT, TERC, NBN, FLT3LG, PRF1, IFNG
26paroxysmal nocturnal hemoglobinuria10.9
27inherited bone marrow failure syndromes10.9
28hemoglobinuria10.9
29hematopoietic stem cell transplantation10.8
30hepatitis10.8
31trichosporonosis10.6IFNG
325q- syndrome10.5EPO
33capillary leak syndrome10.5CSF2
34pseudo-torch syndrome10.5DKC1
35leukemoid reaction10.5CSF3, CSF2, IL3
36cyclic hematopoiesis10.5IL3, CSF2, CSF3
37endophthalmitis10.5PRF1
38acute myeloid leukemia10.5
39pulmonary alveolar proteinosis10.4CSF2, IL3
40paroxysmal nocturnal hemoglobinuria, somatic10.4PIGA, CSF3
41factor vii deficiency10.4CSF3, CSF2, IFNG
42pdgfrb-associated chronic eosinophilic leukemia10.4KITLG, CSF3, CSF2
43bone marrow failure syndrome 210.4
44hemorrhagic thrombocythemia10.4KITLG, IL3, EPO
45polycythemia10.4EPO, IL3, KITLG
46megakaryocytic leukemia10.4IL3, CSF2
47pure red-cell aplasia10.4
48purpura10.4
49diamond-blackfan anemia 110.4KITLG, IL3, EPO
50polycythemia vera10.4EPO, IL3, KITLG

Graphical network of the top 20 diseases related to Aplastic Anemia:



Diseases related to aplastic anemia

Symptoms for Aplastic Anemia

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Symptoms by clinical synopsis from OMIM:

614743

Clinical features from OMIM:

609135,614742,614743

HPO human phenotypes related to Aplastic Anemia:

(show all 9)
id Description Frequency HPO Source Accession
1 cirrhosis rare (5%) HP:0001394
2 autosomal dominant inheritance HP:0000006
3 leukemia HP:0001909
4 aplastic anemia HP:0001915
5 pulmonary fibrosis HP:0002206
6 premature graying of hair HP:0002216
7 adult onset HP:0003581
8 incomplete penetrance HP:0003829
9 bone marrow hypocellularity HP:0005528

Drugs & Therapeutics for Aplastic Anemia

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Genetic Tests for Aplastic Anemia

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Genetic tests related to Aplastic Anemia:

id Genetic test Affiliating Genes
1 Aplastic Anemia22

Anatomical Context for Aplastic Anemia

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MalaCards organs/tissues related to Aplastic Anemia:

32
Bone, Bone marrow, T cells, Lung, Testes, Heart, Liver, Myeloid, Kidney, Colon, Neutrophil, Skin, Monocytes, B cells, Thymus, Thyroid, Endothelial, Fetal liver

Animal Models for Aplastic Anemia or affiliated genes

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Publications for Aplastic Anemia

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Articles related to Aplastic Anemia:

(show top 50)    (show all 866)
idTitleAuthorsYear
1
Increased Bone Marrow (BM) Plasma Level of Soluble CD30 and Correlations with BM Plasma Level of Interferon (IFN)-I^, CD4/CD8 T-Cell Ratio and Disease Severity in Aplastic Anemia. (25383872)
2014
2
Cotransplantation of human umbilical cord mesenchymal and haplo-hematopoietic stem cells in patients with severe aplastic anemia. (25407730)
2014
3
Allogeneic hematopoietic stem cell transplantation for children with severe aplastic anemia. (23724451)
2013
4
Respiratory and systemic infections in children with severe aplastic anemia on immunosuppressive therapy. (23836007)
2013
5
Long-term outcome of childhood aplastic anemia patients who underwent allogeneic hematopoietic SCT from an HLA-matched sibling donor in Japan. (23103680)
2013
6
Less could be better: the case for reducing the dose of cyclophosphamide for children undergoing allogeneic stem cell transplant for severe aplastic anemia. (23581860)
2013
7
In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantation: Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation. (23450467)
2013
8
Tcf-1 gene silence suppresses downstream gene expression in CD4(+) T cells from bone marrow of aplastic anemia patients. (21881822)
2012
9
Exome sequencing identifies MPL as a causative gene in familial aplastic anemia. (22180433)
2012
10
Aplastic anemia in association with a lymphoproliferative neoplasm: coincidence or causality? (21962338)
2012
11
Serum zinc and copper levels in aplastic anemia. (22796694)
2012
12
Eltrombopag in refractory aplastic anemia. (22992084)
2012
13
Long-term follow-up of clonal evolutions in 802 aplastic anemia patients: a single-center experience. (21207031)
2011
14
Comparison between matched related and alternative donors of allogeneic hematopoietic stem cells transplanted into adult patients with acquired aplastic anemia: multivariate and propensity score-matched analysis. (21220035)
2011
15
Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia. (21963603)
2011
16
Comparison of outcomes after transplantation of G-CSF-stimulated bone marrow grafts versus bone marrow or peripheral blood grafts from HLA-matched sibling donors for patients with severe aplastic anemia. (21034842)
2011
17
Transient aplastic anemia in Down's syndrome - a rare association. (21354344)
2011
18
A hospital-based case control study of aplastic anemia in Shanghai, China. (20026322)
2010
19
FDG-PET/CT in diagnosis and early response evaluation of extra-pulmonary tuberculosis in a patient with aplastic anemia. (20739773)
2010
20
Clinical course of non-severe aplastic anemia in adults. (20524094)
2010
21
Case of subcutaneous abscess caused by Nocardia farcinica in an aplastic anemia patient. (20467197)
2010
22
Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia. (20118992)
2010
23
Telomerase gene mutation screening in Chinese patients with aplastic anemia. (19942288)
2010
24
Outcomes of matched sibling and alternative donor stem cell transplantation for 26 children with severe aplastic anemia. (20037749)
2010
25
A novel cell-based therapy for patients with aplastic anemia. (20429786)
2010
26
TINF2 mutations in children with severe aplastic anemia. (19090550)
2009
27
Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma. (19109204)
2009
28
Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bone marrow transplantation from unrelated donors: results of matched pair analysis. (19896085)
2009
29
Changes in cytokine profile pre- and post-immunosuppression in acquired aplastic anemia. (19586939)
2009
30
Treatment of severe aplastic anemia by immunosuppressor anti-lymphocyte globulin/anti-thymus globulin as the chief medicine in combination with Chinese drugs. (19407954)
2009
31
Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia: recommendations for a standardized approach. (19144661)
2009
32
Hematopoietic growth factors in aplastic anemia patients treated with immunosuppressive therapy-systematic review and meta-analysis. (19336743)
2009
33
Feasibility and eligibility of retreatment with rabbit anti-T lymphocyte globulin for aplastic anemia previously treated with horse anti-thymocyte globulin. (19728019)
2009
34
Increased CD4+ and CD8+ effector memory T cells in patients with aplastic anemia. (19181780)
2009
35
Alterations in hematopoietic microenvironment in patients with aplastic anemia. (20443870)
2009
36
Apoptosis induction and phosphorylated protein kinase C epsilon expression in 32D cells by sera from patients with aplastic anemia]. (18844064)
2008
37
Clinical implications of combined measurement bone marrow T cells intracellular IFNgamma and HLA-DRB1*1501 measurement in predicting the response to immunosuppressive therapy for aplastic anemia]. (18218241)
2007
38
Correlation of HLA-alleles with aplastic anemia]. (18088468)
2007
39
Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients. (16079101)
2005
40
Expression of interferon-gamma and tumor necrosis factor-alpha in bone marrow T cells and their levels in bone marrow plasma in patients with aplastic anemia. (15815907)
2005
41
The TNF2 allele is a risk factor to severe aplastic anemia independent of HLA-DR. (12941546)
2003
42
Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy. (12624493)
2003
43
Sustained long-term complete remission in an elderly aplastic anemia patient after cessation of combined therapy consisting of granulocyte-colony stimulating factor and erythropoietin]. (10695398)
2000
44
Aplastic anemia in pregnancy: treatment with cyclosporine and granulocyte-colony stimulating factor. (10326895)
1999
45
Treatment of severe aplastic anemia with an immunosuppressive agent plus recombinant human granulocyte-macrophage colony-stimulating factor and erythropoietin. (9798655)
1998
46
Sweet syndrome in a child with aplastic anemia receiving recombinant granulocyte colony-stimulating factor. (8689342)
1996
47
In vitro effect of stem cell factor on colony growth from acquired severe aplastic anemia. (7691324)
1993
48
Myelodysplasia and leukemia after treatment of aplastic anemia with G-CSF. (1373226)
1992
49
Correlation of response of aplastic anemia patients to antilymphocyte globulin with in vitro lymphocyte stimulatory effect: predictive value of in vitro test for clinical response. (2029581)
1991
50
Use of hematopoietic growth factors for treatment of aplastic anemia. (2285123)
1990

Variations for Aplastic Anemia

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Clinvar genetic disease variations for Aplastic Anemia:

6 (show all 44)
id Gene Name Type Significance SNP ID Assembly Location
1TERTNM_198253.2(TERT): c.604G> A (p.Ala202Thr)single nucleotide variantPathogenicrs121918661GRCh37Chr 5, 1294397: 1294397
2TERTNM_198253.2(TERT): c.1234C> T (p.His412Tyr)single nucleotide variantPathogenicrs34094720GRCh37Chr 5, 1293767: 1293767
3TERTNM_198253.2(TERT): c.2080G> A (p.Val694Met)single nucleotide variantPathogenicrs121918662GRCh37Chr 5, 1279456: 1279456
4TERTNM_198253.2(TERT): c.2315A> G (p.Tyr772Cys)single nucleotide variantPathogenicrs121918663GRCh37Chr 5, 1272367: 1272367
5TERTNM_198253.2(TERT): c.3268G> A (p.Val1090Met)single nucleotide variantPathogenicrs121918664GRCh37Chr 5, 1254510: 1254510
6TERTNM_198253.2(TERT): c.2594G> A (p.Arg865His)single nucleotide variantPathogenicrs121918666GRCh37Chr 5, 1266639: 1266639
7TERTNM_198253.2(TERT): c.2240delT (p.Val747Alafs)deletionPathogenicrs199422300GRCh37Chr 5, 1278802: 1278802
8TERTNM_198253.2(TERT): c.219+1G> Asingle nucleotide variantPathogenicrs199422309GRCh37Chr 5, 1294885: 1294885
9PRF1NM_001083116.1(PRF1): c.1163G> T (p.Ser388Ile)single nucleotide variantPathogenicrs193302875GRCh37Chr 10, 72358314: 72358314
10PRF1NM_001083116.1(PRF1): c.11G> A (p.Arg4His)single nucleotide variantPathogenicrs35418374GRCh37Chr 10, 72360648: 72360648
11SBDSNM_016038.2(SBDS): c.258+2T> Csingle nucleotide variantPathogenicrs113993993GRCh37Chr 7, 66459197: 66459197
12TERTNM_198253.2(TERT): c.2583-2A> Csingle nucleotide variantPathogenicrs111576740GRCh37Chr 5, 1266652: 1266652
13TERTNM_198253.2(TERT): c.164T> A (p.Leu55Gln)single nucleotide variantPathogenicrs387907247GRCh37Chr 5, 1294941: 1294941
14TERTNM_198253.2(TERT): c.2371G> A (p.Val791Ile)single nucleotide variantPathogenicrs141425941GRCh37Chr 5, 1272311: 1272311
15TERTNM_198253.2(TERT): c.508G> A (p.Val170Met)single nucleotide variantPathogenicrs387907248GRCh37Chr 5, 1294493: 1294493
16TERTNM_198253.2(TERT): c.2146G> A (p.Ala716Thr)single nucleotide variantPathogenicrs387907249GRCh37Chr 5, 1278896: 1278896
17TERTNM_198253.2(TERT): c.2705A> G (p.Lys902Arg)single nucleotide variantPathogenicrs387907250GRCh37Chr 5, 1264657: 1264657
18TERTNM_198253.2(TERT): c.2768C> T (p.Pro923Leu)single nucleotide variantPathogenicrs387907251GRCh37Chr 5, 1264594: 1264594
19TERCTERC, 143G-Asingle nucleotide variantPathogenic
20TERCTERC, 212C-Gsingle nucleotide variantPathogenic
21TINF2NM_001099274.1(TINF2): c.862T> C (p.Phe288Leu)single nucleotide variantPathogenicrs199422317GRCh37Chr 14, 24709824: 24709824
22TERTNM_198253.2(TERT): c.2147C> T (p.Ala716Val)single nucleotide variantPathogenicrs199422298GRCh37Chr 5, 1278895: 1278895
23TERTNM_198253.2(TERT): c.2537A> G (p.Tyr846Cys)single nucleotide variantPathogenicrs199422302GRCh37Chr 5, 1268680: 1268680
24TERTNM_198253.2(TERT): c.2628C> G (p.His876Gln)single nucleotide variantPathogenicrs199422303GRCh37Chr 5, 1266605: 1266605
25TERTNM_198253.2(TERT): c.3043T> C (p.Cys1015Arg)single nucleotide variantPathogenicrs199422307GRCh37Chr 5, 1255516: 1255516
26TERTNM_198253.2(TERT): c.3184G> A (p.Ala1062Thr)single nucleotide variantPathogenicrs35719940GRCh37Chr 5, 1254594: 1254594
27TERTNM_198253.2(TERT): c.835G> A (p.Ala279Thr)single nucleotide variantPathogenicrs61748181GRCh37Chr 5, 1294166: 1294166
28TERCNR_001566.1(TERC): n.117A> Csingle nucleotide variantPathogenicrs199422273GRCh37Chr 3, 169482732: 169482732
29TERCNR_001566.1(TERC): n.178G> Asingle nucleotide variantPathogenicrs199422275GRCh37Chr 3, 169482671: 169482671
30TERCNR_001566.1(TERC): n.180C> Tsingle nucleotide variantPathogenicrs199422276GRCh37Chr 3, 169482669: 169482669
31TERCNR_001566.1(TERC): n.28_34delGTGGTGGdeletionPathogenicrs199422259GRCh37Chr 3, 169482815: 169482821
32TERCNR_001566.1(TERC): n.305G> Asingle nucleotide variantPathogenicrs199422279GRCh37Chr 3, 169482544: 169482544
33TERCNR_001566.1(TERC): n.322G> Asingle nucleotide variantPathogenicrs199422280GRCh37Chr 3, 169482527: 169482527
34TERCNR_001566.1(TERC): n.323C> Tsingle nucleotide variantPathogenicrs199422281GRCh37Chr 3, 169482526: 169482526
35TERCNR_001566.1(TERC): n.391_392delCCdeletionPathogenicrs199422283GRCh37Chr 3, 169482457: 169482458
36TERCNR_001566.1(TERC): n.450G> Asingle nucleotide variantPathogenicrs199422287GRCh37Chr 3, 169482399: 169482399
37NBNNM_002485.4(NBN): c.511A> G (p.Ile171Val)single nucleotide variantPathogenic, risk factorrs61754966GRCh37Chr 8, 90990521: 90990521
38TERCNR_001566.1(TERC): n.204C> Gsingle nucleotide variantPathogenicrs199422277GRCh37Chr 3, 169482645: 169482645
39TERCNR_001566.1(TERC): n.58G> Asingle nucleotide variantPathogenicrs113487931GRCh37Chr 3, 169482791: 169482791
40TERCNR_001566.1(TERC): n.72C> Gsingle nucleotide variantPathogenicrs199422265GRCh37Chr 3, 169482777: 169482777
41TERCNR_001566.1(TERC): n.110_113delGACTdeletionPathogenicrs199422270GRCh37Chr 3, 169482736: 169482739
42TERCNR_001566.1(TERC): n.116C> Tsingle nucleotide variantPathogenicrs199422272GRCh37Chr 3, 169482733: 169482733
43TERCNR_001566.1(TERC): n.98G> Asingle nucleotide variantPathogenicrs199422268GRCh37Chr 3, 169482751: 169482751
44TERCTERC, 325G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Aplastic Anemia

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Expression patterns in normal tissues for genes affiliated with Aplastic Anemia

Search GEO for disease gene expression data for Aplastic Anemia.

Pathways for genes affiliated with Aplastic Anemia

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Pathways related to Aplastic Anemia according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IFNG, PRF1
2
Show member pathways
10.2TERT, TINF2
3
Show member pathways
Ras signaling in the CD4+ TCR pathway37
10.0IFNG, PRF1, CD3D
410.0TBX21, CSF2, IFNG
5
Show member pathways
Immune response IL 12 induced IFN gamma production60
10.0IFNG, CD3D, TBX21
610.0KITLG, TBX21, IL3
710.0DKC1, SBDS, NOP10
8
Show member pathways
9.9CSF2, CD3D, IFNG
99.9IFNG, CSF2, CSF3
10
Show member pathways
Immune response CD16 signaling in NK cells60
9.8IL3, CSF2, PRF1, IFNG
11
Show member pathways
9.8CD3D, IFNG, PRF1, IL3
12
Show member pathways
9.8TERT, NBN, TINF2, DKC1
13
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.8CSF2, IFNG, IL3, TBX21
149.8PRF1, IFNG, TBX21, CD3D
159.7IL3, EPO, KITLG, CSF3
169.7IFNG, DKC1, TINF2, NBN, TERT
17
Show member pathways
9.6IL3, KITLG, TERT, DKC1, TINF2
18
Show member pathways
Type III interferon signaling37
9.6EPO, IFNG, IL3, CSF2, CSF3
19
Show member pathways
9.5IL3, CSF3, CSF2, CD3D, KITLG
209.0CSF2, CSF3, KITLG, IL3, EPO, FLT3LG
21
Show member pathways
8.9CSF2, IFNG, EPO, FLT3LG, IL3, CSF3

Compounds for genes affiliated with Aplastic Anemia

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Compounds related to Aplastic Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1tin(2+)4410.3TERT, TERC, NBN, TINF2
2daniplestim4410.3CSF3, KITLG, IL3
3molgramostim4410.3IL3, CSF2, CSF3
4mesna4410.2CSF3, CSF2, IL3
5carboxymethylcellulose4410.2EPO, KITLG, CSF3
6il 114410.2EPO, IL3, CSF3
7thiotepa44 50 1112.2IL3, CSF3, CSF2
8ara-ctp4410.2IL3, CSF2, CSF3
9lenalidomide44 1111.2EPO, CSF3, IL3
10pegfilgrastim44 1111.1EPO, IL3, CSF2, CSF3
11mafosfamide4410.1KITLG, IL3, CSF2, CSF3
124-hydroperoxycyclophosphamide4410.1CSF2, IL3, KITLG, CSF3
13mycophenolate mofetil44 50 1112.1IFNG, CSF3, IL3, EPO
14pseudouridine44 2411.1NOP10, DKC1, TERC
15alemtuzumab44 1111.0CD52, PIGA, CSF3
16ribavirin44 50 1112.0EPO, IFNG, IL3, CSF3, CSF2
17ganciclovir44 1111.0CSF2, CSF3, KITLG, TERT
18hydrocortisone44 2 61 1113.0CSF2, EPO, IFNG, IL3, KITLG
19melphalan44 50 1112.0CSF2, IL3, IFNG, EPO, CSF3
205-aza-2deoxycytidine4410.0KITLG, IL3, TERT, EPO, IFNG
21amifostine44 1110.9EPO, CSF3, CSF2, IL3, KITLG
22filgrastim44 1110.9CSF3, CSF2, EPO, KITLG, IL3
23as 10144 6110.9KITLG, CSF2, IL3
24amphotericin b449.9IFNG, CSF2, CSF3
25daunorubicin44 50 1111.9IL3, KITLG, CSF3, CSF2
26gp 130449.9IL3, KITLG, CSF3, CSF2, EPO
27cytarabine44 50 1111.9KITLG, CSF3, CSF2, EPO, IL3
28agar449.9CSF2, KITLG, IL3, PRF1, TERC
29calcitriol44 61 24 1112.9TERT, EPO, IFNG, IL3, KITLG, CSF2
30rapamycin449.8EPO, IFNG, NBN, TERT, IL3, KITLG
31etoposide44 50 61 1112.8IL3, CSF2, CSF3, NBN, TERC, TERT
32gm-csf44 2810.8CSF2, KITLG, CSF3, IL3, EPO, IFNG
33carboplatin44 50 1111.8CSF2, IL3, KITLG, EPO, CSF3, IFNG
34rhodamine 12344 5010.8FLT3LG, IL3, KITLG
35hydroxyurea44 50 1111.8CSF2, CSF3, KITLG, NBN, IL3, EPO
36rantes449.7IFNG, IL3, CSF3, KITLG, CSF2
37butyrate449.7IL3, IFNG, TERC, TERT, EPO, CSF2
385fluorouracil449.7CSF2, TERT, TERC, IFNG, IL3, CSF3
39pixy321449.7CSF2, FLT3LG, CSF3, KITLG, IL3, EPO
40cyclophosphamide44 50 1111.7FLT3LG, IL3, CSF2, PIGA, CSF3, KITLG
41zidovudine44 50 1111.7TERT, TERC, IL3, CSF2, EPO, KITLG
42cyclosporin a44 28 6111.7CSF3, EPO, IL3, CSF2, KITLG, IFNG
43doxorubicin44 50 1111.7KITLG, CSF3, CSF2, IL3, NBN, TERC
44cisplatin44 50 61 1112.6KITLG, CSF3, CSF2, TERT, TERC, EPO
45idarubicin50 44 1111.6IL3, CSF2, CSF3
46cycloheximide449.5KITLG, CSF3, IL3, IFNG, PRF1, CSF2
47phosphatidylinositol449.5TERT, PIGA, NBN, EPO, IL3, KITLG
48vegf449.4CSF2, FLT3LG, KITLG, TERT, EPO, IFNG
49methylcellulose449.4IL3, PIGA, FLT3LG, CSF2, CSF3, KITLG
50thymidine44 2410.3TERT, TERC, FLT3LG, KITLG, CSF3, CSF2

GO Terms for genes affiliated with Aplastic Anemia

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Cellular components related to Aplastic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1telomerase holoenzyme complexGO:00569710.1DKC1, TERT
2nuclear telomere cap complexGO:0007839.9TERT, TINF2
3extracellular regionGO:0055769.5KITLG, CSF2, IL3, IFNG, PRF1, EPO
4nucleoplasmGO:0056549.3DKC1, TERT, C19orf40, NBN, TINF2, SBDS
5extracellular spaceGO:0056159.2IL3, FLT3LG, EPO, IFNG, CSF2, CSF3

Biological processes related to Aplastic Anemia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.4IFNG, TBX21
2positive regulation of interleukin-23 productionGO:03274710.4CSF2, IFNG
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.2CSF2, IL3, EPO
4telomere maintenance via telomeraseGO:00700410.2TERT, DKC1
5embryonic hemopoiesisGO:03516210.1FLT3LG, IL3, KITLG
6telomere maintenanceGO:00072310.1TERT, NBN, TINF2, DKC1
7T cell differentiationGO:03021710.1CD3D, TBX21
8positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.1KITLG, CSF3, IL3
9rRNA processingGO:00636410.1NOP10, SBDS, DKC1
10cellular response to lipopolysaccharideGO:07122210.1IFNG, CSF2, CSF3
11positive regulation of DNA replicationGO:04574010.0KITLG, CSF2, IL3, EPO
12pseudouridine synthesisGO:00152210.0DKC1, NOP10
13positive regulation of Ras protein signal transductionGO:0465799.8KITLG, EPO
14cell proliferationGO:0082839.8KITLG, SBDS, DKC1, NBN
15positive regulation of cell proliferationGO:0082849.7CSF3, CSF2, IL3, EPO, FLT3LG

Molecular functions related to Aplastic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1telomeric DNA bindingGO:04216210.2TINF2, TERT
2telomerase activityGO:00372010.0DKC1, TERT
3growth factor activityGO:0080839.7CSF3, IL3, KITLG, CSF2
4cytokine activityGO:0051259.4IL3, KITLG, CSF3, CSF2, FLT3LG, IFNG
5protein bindingGO:0055158.0TERT, PIGA, C19orf40, NBN, TINF2, NOP10

Products for genes affiliated with Aplastic Anemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Aplastic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet