MCID: APL001
MIFTS: 76

Aplastic Anemia malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases, Bone diseases categories

Aliases & Classifications for Aplastic Anemia

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Sources:
45OMIM, 30LifeMap Discovery®, 9Disease Ontology, 10diseasecard, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 32MedlinePlus, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Aplastic Anemia, Aliases & Descriptions:

Name: Aplastic Anemia 45 30 9 10 41 11 32 60
Anemia Aplastic 41 43 22
Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2 45 22
Idiopathic Aplastic Anemia 41 47
Secondary Aplastic Anemia 41 60
Bone Marrow Failure 41 47
 
Pulmonary Fibrosis, Idiopathic 45
Aplastic Anemia, Idiopathic 60
Aplastic Anemia Idiopathic 41
Bone Marrow Diseases 60
Bone Marrow Disease 11
Pancytopenia 60


Classifications:



Characteristics (Orphanet epidemiological data):

47
idiopathic aplastic anemia:
Age of onset: Adult; Age of death: adult


External Ids:

Disease Ontology9 DOID:12449
NCIt38 C2870
MeSH33 D000741
ICD9CM27 284.9
Orphanet47 88
MESH via Orphanet34 C538494
ICD10 via Orphanet26 D61.0
UMLS via Orphanet61 C0348890

Summaries for Aplastic Anemia

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MedlinePlus:32 Aplastic anemia is a rare but serious blood disorder. if you have it, your bone marrow doesn't make enough new blood cells. causes include being exposed to toxic substances, such as pesticides, arsenic, and benzene radiation therapy and chemotherapy for cancer certain medicines infections such as hepatitis, epstein-barr virus, or hiv autoimmune disorders certain inherited conditions in many people, the cause is unknown. your doctor will diagnose aplastic anemia based on your medical and family histories, a physical exam, and test results. once your doctor knows the cause and severity of the condition, he or she can create a treatment plan for you. treatments include blood transfusions, blood and marrow stem cell transplants, and medicines. nih: national heart, lung, and blood institute

MalaCards based summary: Aplastic Anemia, also known as anemia aplastic, is related to paroxysmal nocturnal hemoglobinuria and dyskeratosis congenita, and has symptoms including cirrhosis, autosomal dominant inheritance and leukemia. An important gene associated with Aplastic Anemia is IFNG (interferon, gamma), and among its related pathways are Immune response IL 12 signaling pathway and Telomere Extension By Telomerase. The drug carboplatin and the compounds tin(2+) and daniplestim have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are digestive/alimentary and cardiovascular system.

Disease Ontology:9 An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.

NIH Rare Diseases:41 Aplastic anemia is failure of the bone marrow to make enough blood cells. all blood cell types are affected. it can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. when the cause is unknown, it is referred to as idiopathic aplastic anemia. in about half of all cases, no cause can be found. the condition can be acute or chronic. last updated: 8/21/2009

OMIM:45 Aplastic anemia is a serious disorder of the bone marrow that affects between 2 and 5 persons per million per year.... (609135) more...

Wikipedia:63 Aplastic anemia (AA) is a disease in which the bone marrow, and the blood stem cells that reside there,... more...

Description from OMIM:45 614743

Related Diseases for Aplastic Anemia

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Diseases in the Aplastic Anemia family:

Aplastic Anemia, Ifng-Related

Diseases related to Aplastic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1paroxysmal nocturnal hemoglobinuria31.9CSF3, PIGA
2dyskeratosis congenita31.6DKC1, TERC
3myelodysplastic syndrome31.5TERC, PIGA, FLT3LG, CSF2, CSF3, KITLG
4refractory anemia31.4IL3, EPO, CSF2, KITLG, CSF3
5myeloid leukemia31.3KITLG, CSF2, IL3, CSF3
6pulmonary fibrosis, idiopathic31.2TERT, TERC, IFNG
7diamond-blackfan anemia31.0EPO, IL3
8pancytopenia31.0CSF3, EPO, DKC1, IL3, CSF2
9neutropenia30.9CSF2, SBDS, CSF3, IL3, EPO, KITLG
10transient erythroblastopenia of childhood30.8KITLG, EPO
11felty's syndrome30.8IL3, CSF3, CSF2
12severe congenital neutropenia30.8IL3, CSF3, CSF2
13granulocytopenia30.8CSF2, IL3, CSF3
14fanconi anemia, complementation group a30.8DKC1, TERC, NBN, IL3, KITLG
15myelofibrosis30.7EPO, IL3
16chronic myelomonocytic leukemia30.7CSF2, KITLG, CSF3
17essential thrombocythemia30.7IL3, EPO, KITLG
18thrombocytopenia30.7CSF2, PIGA, KITLG, IL3, EPO, FLT3LG
19leukopenia30.6CSF2, IL3, FLT3LG, CSF3, CD52
20myeloma30.5KITLG, CSF2, EPO, IL3, CSF3
21deficiency anemia30.3EPO, IL3, PIGA, TERC, CSF3, CSF2
22leukemia30.3KITLG, TERC, PIGA, FLT3LG, TERT, EPO
23acute leukemia29.8TERT, TERC, KITLG, EPO, IL3, CSF3
24melanoma29.4FLT3LG, IFNG, CSF2, KITLG, PRF1, TERT
25pulmonary fibrosis10.9
26inherited bone marrow failure syndromes10.9
27hemoglobinuria10.9
28hematopoietic stem cell transplantation10.8
29hepatitis10.8
30trichosporonosis10.6IFNG
31macrocytic anemia, refractory, due to 5q deletion, somatic10.5EPO
32capillary leak syndrome10.5CSF2
33band-like calcification with simplified gyration and polymicrogyria10.5DKC1
34leukemoid reaction10.5CSF2, CSF3, IL3
35neutropenia, cyclic10.5IL3, CSF2, CSF3
36endophthalmitis10.5PRF1
37congenital hypoplastic anemia10.4
38pulmonary alveolar proteinosis10.4CSF2, IL3
39factor vii deficiency10.4IFNG, CSF3, CSF2
40bone marrow failure syndrome 210.4
41polycythemia10.4KITLG, EPO, IL3
42megakaryocytic leukemia10.4IL3, CSF2
43pure red-cell aplasia10.4
44purpura10.4
45polycythemia vera10.4EPO, KITLG, IL3
46eosinophilia10.4IL3, CSF2, IFNG
47graft-versus-host disease, protection against10.4CSF3, IFNG, IL3, CSF2
48acute graft versus host disease10.4IFNG, CSF3
49tetanus10.4CSF2, IFNG, FLT3LG
50allergic asthma10.4IFNG, CSF2, IL3

Graphical network of the top 20 diseases related to Aplastic Anemia:



Diseases related to aplastic anemia

Symptoms for Aplastic Anemia

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Symptoms by clinical synopsis from OMIM:

614743

Clinical features from OMIM:

609135,614743

HPO human phenotypes related to Aplastic Anemia:

(show all 9)
id Description Frequency HPO Source Accession
1 cirrhosis rare (5%) HP:0001394
2 autosomal dominant inheritance HP:0000006
3 leukemia HP:0001909
4 aplastic anemia HP:0001915
5 pulmonary fibrosis HP:0002206
6 premature graying of hair HP:0002216
7 adult onset HP:0003581
8 incomplete penetrance HP:0003829
9 bone marrow hypocellularity HP:0005528

Drugs & Therapeutics for Aplastic Anemia

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Genetic Tests for Aplastic Anemia

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Genetic tests related to Aplastic Anemia:

id Genetic test Affiliating Genes
1 Aplastic Anemia22
2 Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 222

Anatomical Context for Aplastic Anemia

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MalaCards organs/tissues related to Aplastic Anemia:

31
Bone, Bone marrow, T cells, Lung, Testes, Heart, Liver, Myeloid, Kidney, Colon, Neutrophil, Skin, Monocytes, B cells, Thymus, Thyroid, Endothelial, Fetal liver

Animal Models for Aplastic Anemia or affiliated genes

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Publications for Aplastic Anemia

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Articles related to Aplastic Anemia:

(show top 50)    (show all 888)
idTitleAuthorsYear
1
Gastric wall perforation secondary to presumed aspergillosis in a pediatric patient with aplastic anemia: A case report. (25881536)
2015
2
Increased Bone Marrow (BM) Plasma Level of Soluble CD30 and Correlations with BM Plasma Level of Interferon (IFN)-I^, CD4/CD8 T-Cell Ratio and Disease Severity in Aplastic Anemia. (25383872)
2014
3
Cotransplantation of human umbilical cord mesenchymal and haplo-hematopoietic stem cells in patients with severe aplastic anemia. (25407730)
2014
4
Allogeneic hematopoietic stem cell transplantation for children with severe aplastic anemia. (23724451)
2013
5
Respiratory and systemic infections in children with severe aplastic anemia on immunosuppressive therapy. (23836007)
2013
6
Long-term outcome of childhood aplastic anemia patients who underwent allogeneic hematopoietic SCT from an HLA-matched sibling donor in Japan. (23103680)
2013
7
Aplastic anemia following viral hepatitis. (24201921)
2013
8
Less could be better: the case for reducing the dose of cyclophosphamide for children undergoing allogeneic stem cell transplant for severe aplastic anemia. (23581860)
2013
9
In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantation: Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation. (23450467)
2013
10
Tcf-1 gene silence suppresses downstream gene expression in CD4(+) T cells from bone marrow of aplastic anemia patients. (21881822)
2012
11
Exome sequencing identifies MPL as a causative gene in familial aplastic anemia. (22180433)
2012
12
Aplastic anemia in association with a lymphoproliferative neoplasm: coincidence or causality? (21962338)
2012
13
Serum zinc and copper levels in aplastic anemia. (22796694)
2012
14
Eltrombopag in refractory aplastic anemia. (22992084)
2012
15
Long-term follow-up of clonal evolutions in 802 aplastic anemia patients: a single-center experience. (21207031)
2011
16
Comparison between matched related and alternative donors of allogeneic hematopoietic stem cells transplanted into adult patients with acquired aplastic anemia: multivariate and propensity score-matched analysis. (21220035)
2011
17
Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia. (21963603)
2011
18
Comparison of outcomes after transplantation of G-CSF-stimulated bone marrow grafts versus bone marrow or peripheral blood grafts from HLA-matched sibling donors for patients with severe aplastic anemia. (21034842)
2011
19
Transient aplastic anemia in Down's syndrome - a rare association. (21354344)
2011
20
A hospital-based case control study of aplastic anemia in Shanghai, China. (20026322)
2010
21
FDG-PET/CT in diagnosis and early response evaluation of extra-pulmonary tuberculosis in a patient with aplastic anemia. (20739773)
2010
22
Clinical course of non-severe aplastic anemia in adults. (20524094)
2010
23
Case of subcutaneous abscess caused by Nocardia farcinica in an aplastic anemia patient. (20467197)
2010
24
Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia. (20118992)
2010
25
Telomerase gene mutation screening in Chinese patients with aplastic anemia. (19942288)
2010
26
Outcomes of matched sibling and alternative donor stem cell transplantation for 26 children with severe aplastic anemia. (20037749)
2010
27
A novel cell-based therapy for patients with aplastic anemia. (20429786)
2010
28
TINF2 mutations in children with severe aplastic anemia. (19090550)
2009
29
Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma. (19109204)
2009
30
Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bone marrow transplantation from unrelated donors: results of matched pair analysis. (19896085)
2009
31
Changes in cytokine profile pre- and post-immunosuppression in acquired aplastic anemia. (19586939)
2009
32
Treatment of severe aplastic anemia by immunosuppressor anti-lymphocyte globulin/anti-thymus globulin as the chief medicine in combination with Chinese drugs. (19407954)
2009
33
Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia: recommendations for a standardized approach. (19144661)
2009
34
Hematopoietic growth factors in aplastic anemia patients treated with immunosuppressive therapy-systematic review and meta-analysis. (19336743)
2009
35
Feasibility and eligibility of retreatment with rabbit anti-T lymphocyte globulin for aplastic anemia previously treated with horse anti-thymocyte globulin. (19728019)
2009
36
Increased CD4+ and CD8+ effector memory T cells in patients with aplastic anemia. (19181780)
2009
37
Apoptosis induction and phosphorylated protein kinase C epsilon expression in 32D cells by sera from patients with aplastic anemia]. (18844064)
2008
38
Clinical implications of combined measurement bone marrow T cells intracellular IFNgamma and HLA-DRB1*1501 measurement in predicting the response to immunosuppressive therapy for aplastic anemia]. (18218241)
2007
39
Correlation of HLA-alleles with aplastic anemia]. (18088468)
2007
40
Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients. (16079101)
2005
41
Expression of interferon-gamma and tumor necrosis factor-alpha in bone marrow T cells and their levels in bone marrow plasma in patients with aplastic anemia. (15815907)
2005
42
The TNF2 allele is a risk factor to severe aplastic anemia independent of HLA-DR. (12941546)
2003
43
Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy. (12624493)
2003
44
Sustained long-term complete remission in an elderly aplastic anemia patient after cessation of combined therapy consisting of granulocyte-colony stimulating factor and erythropoietin]. (10695398)
2000
45
Aplastic anemia in pregnancy: treatment with cyclosporine and granulocyte-colony stimulating factor. (10326895)
1999
46
Treatment of severe aplastic anemia with an immunosuppressive agent plus recombinant human granulocyte-macrophage colony-stimulating factor and erythropoietin. (9798655)
1998
47
Sweet syndrome in a child with aplastic anemia receiving recombinant granulocyte colony-stimulating factor. (8689342)
1996
48
In vitro effect of stem cell factor on colony growth from acquired severe aplastic anemia. (7691324)
1993
49
Myelodysplasia and leukemia after treatment of aplastic anemia with G-CSF. (1373226)
1992
50
Correlation of response of aplastic anemia patients to antilymphocyte globulin with in vitro lymphocyte stimulatory effect: predictive value of in vitro test for clinical response. (2029581)
1991

Variations for Aplastic Anemia

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Clinvar genetic disease variations for Aplastic Anemia:

6 (show all 44)
id Gene Variation Type Significance SNP ID Assembly Location
1TERTNM_198253.2(TERT): c.604G> A (p.Ala202Thr)single nucleotide variantPathogenicrs121918661GRCh37Chr 5, 1294397: 1294397
2TERTNM_198253.2(TERT): c.1234C> T (p.His412Tyr)single nucleotide variantPathogenicrs34094720GRCh37Chr 5, 1293767: 1293767
3TERTNM_198253.2(TERT): c.2080G> A (p.Val694Met)single nucleotide variantPathogenicrs121918662GRCh37Chr 5, 1279456: 1279456
4TERTNM_198253.2(TERT): c.2315A> G (p.Tyr772Cys)single nucleotide variantPathogenicrs121918663GRCh37Chr 5, 1272367: 1272367
5TERTNM_198253.2(TERT): c.3268G> A (p.Val1090Met)single nucleotide variantPathogenicrs121918664GRCh37Chr 5, 1254510: 1254510
6TERTNM_198253.2(TERT): c.2594G> A (p.Arg865His)single nucleotide variantPathogenicrs121918666GRCh37Chr 5, 1266639: 1266639
7TERTNM_198253.2(TERT): c.2240delT (p.Val747Alafs)deletionPathogenicrs199422300GRCh37Chr 5, 1278802: 1278802
8TERTNM_198253.2(TERT): c.219+1G> Asingle nucleotide variantPathogenicrs199422309GRCh37Chr 5, 1294885: 1294885
9PRF1NM_001083116.1(PRF1): c.1163G> T (p.Ser388Ile)single nucleotide variantPathogenicrs193302875GRCh37Chr 10, 72358314: 72358314
10PRF1NM_001083116.1(PRF1): c.11G> A (p.Arg4His)single nucleotide variantPathogenicrs35418374GRCh37Chr 10, 72360648: 72360648
11SBDSNM_016038.2(SBDS): c.258+2T> Csingle nucleotide variantPathogenic, risk factorrs113993993GRCh37Chr 7, 66459197: 66459197
12TERTNM_198253.2(TERT): c.2583-2A> Csingle nucleotide variantPathogenicrs111576740GRCh37Chr 5, 1266652: 1266652
13TERTNM_198253.2(TERT): c.164T> A (p.Leu55Gln)single nucleotide variantPathogenicrs387907247GRCh37Chr 5, 1294941: 1294941
14TERTNM_198253.2(TERT): c.2371G> A (p.Val791Ile)single nucleotide variantPathogenicrs141425941GRCh37Chr 5, 1272311: 1272311
15TERTNM_198253.2(TERT): c.508G> A (p.Val170Met)single nucleotide variantPathogenicrs387907248GRCh37Chr 5, 1294493: 1294493
16TERTNM_198253.2(TERT): c.2146G> A (p.Ala716Thr)single nucleotide variantPathogenicrs387907249GRCh37Chr 5, 1278896: 1278896
17TERTNM_198253.2(TERT): c.2705A> G (p.Lys902Arg)single nucleotide variantPathogenicrs387907250GRCh37Chr 5, 1264657: 1264657
18TERTNM_198253.2(TERT): c.2768C> T (p.Pro923Leu)single nucleotide variantPathogenicrs387907251GRCh37Chr 5, 1264594: 1264594
19TERCTERC, 143G-Asingle nucleotide variantPathogenic
20TERCTERC, 212C-Gsingle nucleotide variantPathogenic
21TINF2NM_001099274.1(TINF2): c.862T> C (p.Phe288Leu)single nucleotide variantPathogenicrs199422317GRCh37Chr 14, 24709824: 24709824
22TERTNM_198253.2(TERT): c.2147C> T (p.Ala716Val)single nucleotide variantPathogenicrs199422298GRCh37Chr 5, 1278895: 1278895
23TERTNM_198253.2(TERT): c.2537A> G (p.Tyr846Cys)single nucleotide variantPathogenicrs199422302GRCh37Chr 5, 1268680: 1268680
24TERTNM_198253.2(TERT): c.2628C> G (p.His876Gln)single nucleotide variantPathogenicrs199422303GRCh37Chr 5, 1266605: 1266605
25TERTNM_198253.2(TERT): c.3043T> C (p.Cys1015Arg)single nucleotide variantPathogenicrs199422307GRCh37Chr 5, 1255516: 1255516
26TERTNM_198253.2(TERT): c.3184G> A (p.Ala1062Thr)single nucleotide variantPathogenic, risk factorrs35719940GRCh37Chr 5, 1254594: 1254594
27TERTNM_198253.2(TERT): c.835G> A (p.Ala279Thr)single nucleotide variantPathogenicrs61748181GRCh37Chr 5, 1294166: 1294166
28TERCNR_001566.1(TERC): n.117A> Csingle nucleotide variantPathogenicrs199422273GRCh37Chr 3, 169482732: 169482732
29TERCNR_001566.1(TERC): n.178G> Asingle nucleotide variantPathogenicrs199422275GRCh37Chr 3, 169482671: 169482671
30TERCNR_001566.1(TERC): n.180C> Tsingle nucleotide variantPathogenicrs199422276GRCh37Chr 3, 169482669: 169482669
31TERCNR_001566.1(TERC): n.28_34delGTGGTGGdeletionPathogenicrs199422259GRCh37Chr 3, 169482815: 169482821
32TERCNR_001566.1(TERC): n.305G> Asingle nucleotide variantPathogenicrs199422279GRCh37Chr 3, 169482544: 169482544
33TERCNR_001566.1(TERC): n.322G> Asingle nucleotide variantPathogenicrs199422280GRCh37Chr 3, 169482527: 169482527
34TERCNR_001566.1(TERC): n.323C> Tsingle nucleotide variantPathogenicrs199422281GRCh37Chr 3, 169482526: 169482526
35TERCNR_001566.1(TERC): n.391_392delCCdeletionPathogenicrs199422283GRCh37Chr 3, 169482457: 169482458
36TERCNR_001566.1(TERC): n.450G> Asingle nucleotide variantPathogenicrs199422287GRCh37Chr 3, 169482399: 169482399
37NBNNM_002485.4(NBN): c.511A> G (p.Ile171Val)single nucleotide variantPathogenic, risk factorrs61754966GRCh37Chr 8, 90990521: 90990521
38TERCNR_001566.1(TERC): n.204C> Gsingle nucleotide variantPathogenicrs199422277GRCh37Chr 3, 169482645: 169482645
39TERCNR_001566.1(TERC): n.58G> Asingle nucleotide variantPathogenicrs113487931GRCh37Chr 3, 169482791: 169482791
40TERCNR_001566.1(TERC): n.72C> Gsingle nucleotide variantPathogenicrs199422265GRCh37Chr 3, 169482777: 169482777
41TERCNR_001566.1(TERC): n.110_113delGACTdeletionPathogenicrs199422270GRCh37Chr 3, 169482736: 169482739
42TERCNR_001566.1(TERC): n.116C> Tsingle nucleotide variantPathogenicrs199422272GRCh37Chr 3, 169482733: 169482733
43TERCNR_001566.1(TERC): n.98G> Asingle nucleotide variantPathogenicrs199422268GRCh37Chr 3, 169482751: 169482751
44TERCTERC, 325G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Aplastic Anemia

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Search GEO for disease gene expression data for Aplastic Anemia.

Pathways for genes affiliated with Aplastic Anemia

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Pathways related to Aplastic Anemia according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IFNG, PRF1
2
Show member pathways
10.2TERT, TINF2
3
Show member pathways
Ras signaling in the CD4+ TCR pathway36
10.0CD3D, IFNG, PRF1
410.0IFNG, CSF2, TBX21
5
Show member pathways
Immune response IL 12 induced IFN gamma production58
10.0CD3D, TBX21, IFNG
610.0IL3, TBX21, KITLG
710.0NOP10, SBDS, DKC1
8
Show member pathways
9.9CD3D, CSF2, IFNG
99.9IFNG, CSF2, CSF3
10
Show member pathways
Immune response CD16 signaling in NK cells58
9.8PRF1, IFNG, IL3, CSF2
11
Show member pathways
9.8CD3D, IL3, IFNG, PRF1
12
Show member pathways
9.8TERT, NBN, TINF2, DKC1
13
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.8TBX21, CSF2, IL3, IFNG
149.8PRF1, IFNG, TBX21, CD3D
159.7KITLG, CSF3, IL3, EPO
169.7TERT, NBN, TINF2, DKC1, IFNG
17
Show member pathways
9.6TERT, TINF2, DKC1, IL3, KITLG
18
Show member pathways
Type III interferon signaling36
9.6EPO, IFNG, IL3, CSF2, CSF3
19
Show member pathways
9.5IL3, CSF2, CSF3, KITLG, CD3D
209.0CD3D, KITLG, CSF3, CSF2, IL3, EPO
21
Show member pathways
8.9FLT3LG, EPO, IFNG, IL3, CSF2, CSF3

Compounds for genes affiliated with Aplastic Anemia

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Compounds related to Aplastic Anemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1tin(2+)4310.3TERT, TERC, NBN, TINF2
2daniplestim4310.3CSF3, KITLG, IL3
3molgramostim4310.3IL3, CSF2, CSF3
4mesna4310.2CSF3, CSF2, IL3
5carboxymethylcellulose4310.2EPO, KITLG, CSF3
6il 114310.2EPO, IL3, CSF3
7thiotepa43 49 1212.2IL3, CSF3, CSF2
8ara-ctp4310.2IL3, CSF2, CSF3
9lenalidomide43 1211.2EPO, CSF3, IL3
10pegfilgrastim43 1211.1EPO, IL3, CSF2, CSF3
11mafosfamide4310.1KITLG, IL3, CSF2, CSF3
124-hydroperoxycyclophosphamide4310.1CSF2, IL3, KITLG, CSF3
13mycophenolate mofetil43 49 1212.1IFNG, CSF3, IL3, EPO
14pseudouridine43 2411.1NOP10, DKC1, TERC
15alemtuzumab43 1211.0CD52, PIGA, CSF3
16ribavirin43 49 1212.0EPO, IFNG, IL3, CSF3, CSF2
17ganciclovir43 1211.0CSF2, CSF3, KITLG, TERT
18hydrocortisone43 2 59 1213.0CSF2, EPO, IFNG, IL3, KITLG
19melphalan43 49 1212.0CSF2, IL3, IFNG, EPO, CSF3
205-aza-2deoxycytidine4310.0KITLG, IL3, TERT, EPO, IFNG
21amifostine43 1210.9EPO, CSF3, CSF2, IL3, KITLG
22filgrastim43 1210.9CSF3, CSF2, EPO, KITLG, IL3
23as 10143 5910.9KITLG, CSF2, IL3
24amphotericin b439.9IFNG, CSF2, CSF3
25daunorubicin43 49 1211.9IL3, KITLG, CSF3, CSF2
26gp 130439.9IL3, KITLG, CSF3, CSF2, EPO
27cytarabine43 49 1211.9KITLG, CSF3, CSF2, EPO, IL3
28agar439.9CSF2, KITLG, IL3, PRF1, TERC
29calcitriol43 59 24 1212.9TERT, EPO, IFNG, IL3, KITLG, CSF2
30rapamycin439.8EPO, IFNG, NBN, TERT, IL3, KITLG
31etoposide43 49 59 1212.8IL3, CSF2, CSF3, NBN, TERC, TERT
32gm-csf43 2810.8CSF2, KITLG, CSF3, IL3, EPO, IFNG
33carboplatin43 49 1211.8CSF2, IL3, KITLG, EPO, CSF3, IFNG
34rhodamine 12343 4910.8FLT3LG, IL3, KITLG
35hydroxyurea43 49 1211.8CSF2, CSF3, KITLG, NBN, IL3, EPO
36rantes439.7IFNG, IL3, CSF3, KITLG, CSF2
37butyrate439.7IL3, IFNG, TERC, TERT, EPO, CSF2
385fluorouracil439.7CSF2, TERT, TERC, IFNG, IL3, CSF3
39pixy321439.7CSF2, FLT3LG, CSF3, KITLG, IL3, EPO
40cyclophosphamide43 49 1211.7FLT3LG, IL3, CSF2, PIGA, CSF3, KITLG
41zidovudine43 49 1211.7TERT, TERC, IL3, CSF2, EPO, KITLG
42cyclosporin a43 28 5911.7CSF3, EPO, IL3, CSF2, KITLG, IFNG
43doxorubicin43 49 1211.7KITLG, CSF3, CSF2, IL3, NBN, TERC
44cisplatin43 49 59 1212.6KITLG, CSF3, CSF2, TERT, TERC, EPO
45idarubicin49 43 1211.6IL3, CSF2, CSF3
46cycloheximide439.5KITLG, CSF3, IL3, IFNG, PRF1, CSF2
47phosphatidylinositol439.5TERT, PIGA, NBN, EPO, IL3, KITLG
48vegf439.4CSF2, FLT3LG, KITLG, TERT, EPO, IFNG
49methylcellulose439.4IL3, PIGA, FLT3LG, CSF2, CSF3, KITLG
50thymidine43 2410.3TERT, TERC, FLT3LG, KITLG, CSF3, CSF2

GO Terms for genes affiliated with Aplastic Anemia

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Cellular components related to Aplastic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1telomerase holoenzyme complexGO:000569710.1DKC1, TERT
2nuclear telomere cap complexGO:00007839.9TERT, TINF2
3extracellular regionGO:00055769.5KITLG, CSF2, IL3, IFNG, PRF1, EPO
4nucleoplasmGO:00056549.3DKC1, TERT, C19orf40, NBN, TINF2, SBDS
5extracellular spaceGO:00056159.2IL3, FLT3LG, EPO, IFNG, CSF2, CSF3

Biological processes related to Aplastic Anemia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:004830410.4IFNG, TBX21
2positive regulation of interleukin-23 productionGO:003274710.4CSF2, IFNG
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.2CSF2, IL3, EPO
4telomere maintenance via telomeraseGO:000700410.2TERT, DKC1
5embryonic hemopoiesisGO:003516210.1FLT3LG, IL3, KITLG
6telomere maintenanceGO:000072310.1TERT, NBN, TINF2, DKC1
7T cell differentiationGO:003021710.1CD3D, TBX21
8positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.1KITLG, CSF3, IL3
9rRNA processingGO:000636410.1NOP10, SBDS, DKC1
10cellular response to lipopolysaccharideGO:007122210.1IFNG, CSF2, CSF3
11positive regulation of DNA replicationGO:004574010.0KITLG, CSF2, IL3, EPO
12pseudouridine synthesisGO:000152210.0DKC1, NOP10
13positive regulation of Ras protein signal transductionGO:00465799.8KITLG, EPO
14cell proliferationGO:00082839.8KITLG, SBDS, DKC1, NBN
15positive regulation of cell proliferationGO:00082849.7CSF3, CSF2, IL3, EPO, FLT3LG

Molecular functions related to Aplastic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1telomeric DNA bindingGO:004216210.2TINF2, TERT
2telomerase activityGO:000372010.0DKC1, TERT
3growth factor activityGO:00080839.7CSF3, IL3, KITLG, CSF2
4cytokine activityGO:00051259.4IL3, KITLG, CSF3, CSF2, FLT3LG, IFNG
5protein bindingGO:00055158.0TERT, PIGA, C19orf40, NBN, TINF2, NOP10

Products for genes affiliated with Aplastic Anemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Aplastic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet