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Aplastic Anemia malady
7 drugs, 122 genes, 12 tissues, 1210 related diseases, 27 phenotypes, 276 articles, clinical trials.

Summaries for Aplastic Anemia

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30NIH Rare Diseases, 23MedlinePlus, 44Wikipedia, 33OMIM, 22MalaCards
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MedlinePlus: Aplastic anemia is a rare but serious blood disorder. if you have it, your bone marrow doesn't make enough new blood cells. causes include being exposed to toxic substances, such as pesticides, arsenic, and benzene radiation therapy and chemotherapy for cancer certain medicines infections such as hepatitis, epstein-barr virus, or hiv autoimmune disorders certain inherited conditions in many people, the cause is unknown. your doctor will diagnose aplastic anemia based on your medical and family histories, a physical exam, and test results. once your doctor knows the cause and severity of the condition, he or she can create a treatment plan for you. treatments include blood transfusions, blood and marrow stem cell transplants, and medicines. nih: national heart, lung, and blood institute23

MalaCards: Aplastic Anemia, also known as anemia aplastic, is related to hemolytic anemia and paroxysmal nocturnal hemoglobinuria. An important gene associated with Aplastic Anemia is TERC (telomerase RNA component), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Graft-versus-host disease. The drugs nandrolone and oxymetholone and the compounds cyclophosphamide and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and heart, and related mouse phenotypes are embryogenesis and respiratory system.

NIH Rare Diseases: Aplastic anemia is failure of the bone marrow to make enough blood cells. All blood cell types are affected. It can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. When the cause is unknown, it is referred to as idiopathic aplastic anemia. In about half of all cases, no cause can be found. The condition can be acute or chronic.30

Wikipedia: Aplastic anemia is a condition where bone marrow does not produce sufficient new cells to replenish...44 more...

OMIM: 609135

Aliases & Descriptions for Aplastic Anemia

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43UMLS, 6Disease Ontology, 7diseasecard, 30NIH Rare Diseases, 17Genetics Home Reference, 8DISEASES, 33OMIM, 23MedlinePlus, 32Novoseek , 27NCIt, 24MeSH, 40SNOMED-CT, 19ICD9CM
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Aliases & Descriptions:

aplastic anemia 6 7 30 17 8 33 23 43
anemia aplastic 30 32
aplastic anemia idiopathic 30
idiopathic aplastic anemia 30
secondary aplastic anemia 30
anemia 43

Related Diseases for Aplastic Anemia

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13GeneCards, 14GeneDecks
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Diseases related to aplastic anemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1207)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia37.3PIGA, CD59, CD55, HFE, PGK1, EPO
2paroxysmal nocturnal hemoglobinuria35.4PIGA, CD59, CD55, PLAUR, CSF3
3myelodysplastic syndrome34.5PIGA, KITLG, MPL, CD59, CD34, CD55
4fanconi's anemia34.3KITLG, NBN, CD79A, CD40LG, CD34, INS
5iron deficiency anemia34.2IL11, ALB, TNF, CYP1A1, HFE, THPO
6hemoglobinuria33.7PIGA, CD59, CD52, CD55, ANXA5, HPRT1
7sickle cell anemia33.4KITLG, VCAM1, CD79A, CD40LG, ITGA2B, ITGB3
8hepatitis33.1FASLG, FAS, ALB, HLA-A, HLA-DRB1, CYP2E1
9beta thalassemia32.7ANXA5, HFE, EPO, GATA1
10autoimmune hemolytic anemia32.6PIGA, T, CD79A, CD59, CD40LG, CD52
11macrocytic anemia32.3RPL35A, RPS17, RPS24, RPL5, RPS19, RPL11
12dyskeratosis congenita32.1TERC, TERT, DKC1, DCLRE1B
13dyserythropoietic anemia with thrombocytopenia32.0PIGA, KITLG, MPL, CD59, CD55, IL11
14essential thrombocythemia30.5KITLG, MPL, IL11, IL3, THPO, EPO
15congenital amegakaryocytic thrombocytopenia30.4MPL, IL3, THPO
16diamond-blackfan anemia30.3KITLG, RPL5, RPL11
17systemic lupus erythematosus30.3PDCD1, FOXP3, FASLG, PTPN22, CTLA4
18pure red-cell aplasia30.3KITLG, TRB@, EPO
19myelofibrosis30.0FGF2, THPO, EPO
20malaria29.7CD40LG, IL10, IL4, IFNG, TNF, NOS2
21miliary tuberculosis29.6IL10, IL18, IFNG, ALB, CSF3, EPO
22iron overload29.6INS, GSTM1, ALB, HLA-A, HLA-B, TNF
23dyskeratosis29.5KITLG, IL3, ALB, TP53, TERC, TERT
24x-linked sideroblastic anemia29.0PIGA, CD59, CD55, IL1B, TNF
25hepatitis c28.8CD28, CD40LG, IL10, IL12B, IL18, IL4
26chronic kidney failure28.5CD79A, INS, ALB, EPO
27toxic epidermal necrolysis28.4FASLG, FAS, HLA-A, HLA-B, HLA-DRB1, TNF
28thalassemia28.4VCAM1, FOXP3, INS, GSTM1, GSTT1, IL1B
29rheumatoid arthritis28.4IL10, IL1B, IL23A, IL23R, HLA-DRB1, TNF
30arthritis28.3IL1B, IL6, TNF, PLAUR
31erythrocytosis28.2KITLG, MPL, IL11, IL3, EPO
32thrombocytosis28.2KITLG, VEGFA, MPL, CD79A, CD40LG, FLT3
33hodgkin's lymphoma28.1SH2D1A, CD28, FLT3, IL2RA, IL3, IGH@
34tuberculosis27.8IL10, IL12B, IL1B, IL4, IFNG, TNF
35thymoma27.8CD55, IL12B, IL18, FAS, IFNG, HLA-A
36acute lymphoblastic leukemia27.8KITLG, NBN, MPL, CD59, CD34, FLT3
37gastritis27.7CD34, GSTT1, TERC, TERT, NOS2
38chronic lymphocytic leukemia27.7CD28, CD59, CD40LG, CD52, CD55, FLT3
39b-cell lymphomas27.5NBN, FLT3, GSTP1, FAS, CCND3, IGH@
40chronic granulomatous disease27.1CD79A, CD40LG, IFNG, TNF, PRF1, CSF2
41gaucher's disease26.9IL18, IL6, TNF, CYP1A1, HFE, CSF1
42chronic myeloid leukemia26.9KITLG, MPL, CD59, CD34, CD55, ITGB3
43short stature26.8INS, ALB, NRAS, RPL35A, RPS17, RPS24
44hypersplenism26.6IL11, ALB, THPO, CSF2, CSF3, EPO
45macrothrombocytopenia26.6ITGA2B, ITGB3, THPO, GATA1
46hemophagocytic lymphohistiocytosis26.6SH2D1A, IL18, IL2RA, PRF1
47plasmodium falciparum malaria26.6CD55, IL10, IL18, IFNG, HLA-B, HLA-DRB1
48thrombotic thrombocytopenic purpura, acquired26.5VEGFA, CD40LG, ITGB3, IFNG, HLA-A, HLA-B
49pancytopenia26.4PIGA, SH2D1A, NBN, MPL, CD59, CD55
50celiac disease26.4IL6, HLA-DQB1, HLA-DRB1, TNF, CTLA4

Graphical network of the top 20 diseases related to aplastic anemia:



Graphical network of diseases related to aplastic anemia

Clinical Features for Aplastic Anemia

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33OMIM
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Clinical features from OMIM: 609135

Drugs & Therapeutics for Aplastic Anemia

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for aplastic anemia

Drug clinical trials:

Search ClinicalTrials for aplastic anemia

Search NIH Clinical Center for aplastic anemia

Search CenterWatch for aplastic anemia

Inferred drug relations via UMLS/NDF-RT:

43 28 darbepoetin alfa,recombinant, epoetin alfa,recombinant, nandrolone, nandrolone decanoate, nandrolone phenpropionate, oxymetholone, sodium ascorbate

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for aplastic anemia:
Bone marrow-derived mesenchymal stem cells for treatment of aplastic anemia
Hematopoietic stem cell transplantation for treatment of refractory severe aplastic anemia
Umbilical cord stem cells together with haploidentical peripheral blood CD34+ cells for treating Severe Aplastic Anemia

Genetic Tests for Aplastic Anemia

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Anatomical Context for Aplastic Anemia

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22MalaCards
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MalaCards organs/tissues related to aplastic anemia:

22
Bone marrow, Thymus, Heart, Kidney, Liver, Lung, Myeloid, T cells, B lymphoblasts, B cells, Fetal liver, Fetal lung

Phenotypes for genes affiliated with Aplastic Anemia

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25MGI
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MGI Mouse Phenotypes related to aplastic anemia:

25 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1embryogenesis phenotypeMP:000538010.4TERC, TERF1, NRAS, NOTCH1, NFATC2, GFI1B
2respiratory system phenotypeMP:000538810.3TBX21, NFATC2, DKC1, GATA1, PTPN22, HPRT1
3endocrine/exocrine gland phenotypeMP:000537910.1GATA2, CTLA4, TERF1, HPRT1, IFNG, FASLG
4craniofacial phenotypeMP:000538210.1NOTCH1, NFATC2, CSF1, CSF2, GATA3, TERF1
5renal/urinary system phenotypeMP:00053679.4PDCD1, MTOR, CD55, INS, HPRT1, PLG
6pigmentation phenotypeMP:00011869.4GATA3, RPS19, NOTCH1, CTLA4, TERF1, TERC
7hematopoietic system phenotypeMP:00053979.1RPS19, NFATC2, GFI1B, THPO, DKC1, CSF2
8limbs/digits/tail phenotypeMP:00053719.1NRAS, RPS19, HFE, TGFB2, TERC, FAS
9integument phenotypeMP:00107718.9PIGA, KITLG, T, CD34, ITGB3, FOXP3
10no phenotypic analysisMP:00030128.8TP53, TERF1, CYP1A1, KTN1, TINF2, DKC1
11liver/biliary system phenotypeMP:00053708.6VEGFA, SBDS, INS, IL6, IFNG, HPRT1
12skeleton phenotypeMP:00053907.9TERC, TERT, CTLA4, NOTCH1, NFATC2, TGFB2
13nervous system phenotypeMP:00036317.7PLG, PLAUR, TBX21, TERT, TERC, NFATC2
14digestive/alimentary phenotypeMP:00053817.6TERC, TERF1, TERT, TBX21, CTLA4, NRAS
15immune system phenotypeMP:00053877.5SH2D1A, HPRT1, HLA-DQB1, TRB@, TP53, TNF
16adipose tissue phenotypeMP:00053756.7NOS2, TGFB1, DKC1, PRKCE, CSF2, GATA3
17growth/size phenotypeMP:00053786.6T, TERC, TERF1, TERT, PTPN22, NRAS
18behavior/neurological phenotypeMP:00053866.6CYP2E1, TERC, HLA-DQB1, HPRT1, IFNG, PLAUR
19mortality/agingMP:00107686.5VCAM1, SBDS, T, MPL, CD59, ITGB3
20reproductive system phenotypeMP:00053896.4HPRT1, TNF, TERC, PLG, NOS2, TGFB1
21normal phenotypeMP:00028736.0T, MSN, CD28, CD79A, CD52, ITGB3
22tumorigenesisMP:00020065.7ITGB3, FN1, GSTP1, FGF2, IL10, IL12A
23vision/eye phenotypeMP:00053915.3NRAS, TERC, TNF, TP53, HPRT1, PLG
24muscle phenotypeMP:00053695.2TP53, TNF, TERC, PLAUR, NOS2, NOTCH1
25cardiovascular system phenotypeMP:00053853.7NRAS, PLAUR, PLG, NOS2, NOTCH1, GFI1B
26homeostasis/metabolism phenotypeMP:00053763.1HFE, GFI1B, TGFB1, TGFB2, DKC1, PRKCE
27cellular phenotypeMP:00053842.4VEGFA, VCAM1, MTOR, SBDS, MPL, CD28

Publications for genes affiliated with Aplastic Anemia

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35PubMed
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Articles related to aplastic anemia:

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idTitleAuthorsYearAffiliating Genes
1Proliferation and apoptosis of bone marrow CD4(+) T c ells in patients with aplastic anemia and impacts of the secreted cytokines on hematopoietic stem cells from umbilical cord blood. (20155453)Zheng M.... Liu W.2010INS
2Subcutaneous alemtuzumab plus cyclosporine for the tr eatment of aplastic anemia. (19705116)GA^mez-Almaguer D.... RodrA-guez-Romo L.2010CD52
3Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma. (19109204)Takamatsu H.... Nakao S.2009IFNG
4The frequency of HLA class I and II alleles in Pakist ani patients with aplastic anemia. (19860590)Rehman S.... Mehmood T.2009HLA-A, HLA-DRB1, HLA-B
5Study on HFE gene mutations in patients with myelody splastic syndromes and aplastic anemia (19731820)Nie L.... Xiao Z.J.2009HFE
6Detection of putative T cell clones using T cell rec eptor beta chain gene clonality assay in Korean patients with aplastic anemia (19726886)Choi H.J.... Ryang D.W.2009TRB@
7Characterization of myelodysplastic syndrome and aplastic anemia by immunostaining of p53 and hemoglobin F and karyotype analysis: differential diagnosis between refractory anemia and aplastic anemia. (18477214)Iwasaki T.... Murate T.2008TP53, FHQTL
8Quantitative comparisons of antibody-binding sites of platelet glycoprotein IIb/IIIa in aplastic anemia and idiopathic thrombocytopenic purpura. (18316775)Kahng J.... Lee W.2008ITGA2B, ITGB3
9Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia (18426658)Chang H.... Meng W.T.2008IFNG
10Clinical implications of combined measurement bone m arrow T cells intracellular IFNgamma and HLA-DRB1*1501 measurement in predictin g the response to immunosuppressive therapy for aplastic anemia (18218241)Chen Y.... Ge L.F.2007IFNG
11Mutation of SBDS and SH2D1A is not associated with aplastic anemia in Japanese children. (18024409)Wang Y.... Kojima S.2007SH2D1A, SBDS
12Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan. (17526862)Teramura M.... Mizoguchi H.2007CSF3
13Acute arrest of hemopoiesis mimics aplastic anemia: 23 cases report (18457266)Yan Z.S.... Zhang F.K.2007ALB
14Flow cytometric evaluation of circulating CD34+ cell counts and apoptotic rate in children with acquired aplastic anemia and myelodysplasia. (15850838)Timeus F.... Saracco P.2005ANXA5
15Immunosuppressive therapy for aplastic anemia in chil dren: a more severe disease predicts better survival. (15933058)FA1hrer M.... Bender-Goetze C.2005CSF3
16Effects of serum from aplastic anemia patients on the expression of cyclin D3 isoform in umbilical cord blood CD34+ cells. (15315335)Meng F.... Sun L.2004CCND3
17Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency. (15319288)Marrone A.... Mason P.J.2004TERC
18Hepatitis-associated aplastic anemia preceded by a hemophagocytic syndrome-like state (14639947)Matsunawa M.... Tomoyasu S.2003CSF3
19Time course changes in the count of peripheral granulocytes in children with acquired aplastic anemias treated with antithymocyte globulin, cyclosporin A and granulocytic colony stimulating factor (12577848)Bogacheva N.I.u.... Maschan A.A.2002IL3, CSF3
20Severe aplastic anemia associated with hepatitis and complicated by pulmonary aspergillosis: response to immune suppression and anti fungal therapy. (12194507)Bond R.... Trigg M.E.2002CSF3
21Long-term follow-up of patients with aplastic anemia and refractory anemia responding to combination therapy with recombinant human granulocyte colony-stimulating factor and erythropoietin. (12416735)Matsuda A.... Bessho M.2002EPO
22Stem cell defect in aplastic anemia: reduced long term culture-initiating cells (LTC-IC) in CD34+ cells isolated from aplastic anemia patient bone marrow. (12391540)Rizzo S.... Gibson F.M.2002CD34
23Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia. (11719393)Lee K.A.... Cho H.C.2001GSTT1, GSTM1
24Acute myelogenous leukemia with PIG-A gene mutation evolved from aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome. (11372733)Tanaka H.... Kimura A.2001PIGA
25N-RAS gene mutation in patients with aplastic anemia and aplastic anemia/ paroxysmal nocturnal hemoglobinuria during evolution to clonal disease. (10627475)Mortazavi Y.... Rutherford T.R.2000NRAS, PIGA
26An enzymologic study on bone marrow cells in patients with aplastic anemia treated by supplementing the kidney and removing blood st asis. (11038975)Wang S.... Li Z.2000SDHB
27Recovery of hematopoietic progenitor cells in patients with severe aplastic anemia who obtained good clinical response with a combination therapy of immunosuppressive agents and recombinant human granulocyte colony-stimulating factor. (10979207)Matsuo Y.... Tomonaga M.2000CSF3
28Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italiano Trapianti di Midolio Osseo (GITMO). (10706857)Bacigalupo A.... Ferster A.2000CSF3
29Granulocyte colony-stimulating factor-supported combi ned immunosuppressive therapy (antilymphocyte globulin, cyclosporine, and methy lprednisolone) in patients with aplastic anemia: tolerability, efficacy, and ch anges in the progenitor cell compartment. (10466441)Meidlinger P.... Geissler K.1999CSF3
30The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow. (9590652)Slanicka Krieger M.... Wodnar-Filipowicz A.1998FLT3, KITLG, FLT3LG
31Paroxysmal nocturnal hemoglobinuria and its association with aplastic anemia (9748736)Pavlu J.... Necas E.1998PIGA
32Erythropoietin therapy for aplastic anemia. (9617855)Yoshida Y.1998EPO
33Hematopoietic growth factors and marrow stroma in aplastic anemia. (9713165)Koijima S.1998KITLG, IL3, THPO
34Effect of flt3 ligand on in vitro growth and expansion of colony-forming bone marrow cells from patients with aplastic anemia. (9216732)Wodnar-Filipowicz A.... Nissen C.1997FLT3, KITLG, IL3
35Flt3 ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia. (8977241)Wodnar-Filipowicz A.... Nissen C.1996FLT3, FLT3LG
36Transformation of severe aplastic anemia into acute myeloblastic leukemia with monosomy 7. (8645749)Hashino S.... Asaka M.1996IL6, CSF3, EPO
37Production of hematopoietic regulatory cytokines by peripheral blood mononuclear cells in patients with aplastic anemia. (8536789)Hsu H.C.... Wang S.Y.1996KITLG, IL3, TGFB2
38Two patients with aplastic anemia successfully treated with G-CSF and erythropoietin (8587170)Hanamura A.... Hotta T.1995CSF3, EPO
39Complete remission achieved by low-dose Ara-C, aclarubicin and rhG-CSF (CAG) therapy in acute non-lymphocytic leukemia with monosomy 7 occurring after severe aplastic anemia (7536277)Yamato H.... Enokihara H.1995CSF3
40Early trilineage recovery by granulocyte colony-stimulating factor in a patient with aplastic anemia. (7543718)Hashimoto K.... Matsuzawa Y.1995CSF3
41RAEB in T with monosomy 7 after treatment of severe aplastic anemia with long term G-CSF (7540227)Kaito K.... Sakai O.1995CSF3
42Successful bone marrow transplantation with rabbit anti-human thymocyte globulin in aplastic anemia. Report of a case previously treated with equine anti-human lymphocyte globulin. (7919240)Yoshida Y.... Okuma M.1994IL3
43In vitro effect of stem cell factor on colony growth from acquired severe aplastic anemia. (7691324)Bacigalupo A.... Bagnara G.P.1993KITLG
44Production of granulocyte colony-stimulating factor and granulocyte/macrophage-colony-stimulating factor after interleukin-1 stimulation of marrow stromal cell cultures from normal or aplastic anemia donors. (1377699)Migliaccio A.R.... Torok-Storb B.1992CSF3, CSF1
45Interferon-gamma gene expression in unstimulated bone marrow mononuclear cells predicts a good response to cyclosporine therapy in aplastic anemia. (1586705)Nakao S.... Matsuda T.1992IFNG, CCL3
46Effect of interleukin-3 on responsiveness to granulocyte-colony-stimulating factor in severe aplastic anemia. (1377461)Geissler K.... Lechner K.1992IL3, CSF3
47Hematopoietic growth factors released by marrow stromal cells from patients with aplastic anemia. (1373968)Kojima S.... Kodera Y.1992IL3, CSF2, CSF3
48Clinical trials of granulocyte-macrophage colony-stimulating factor for the treatment of aplastic anemia. (1504150)Vadhan-Raj S.1992CSF2
49Remarkable improvement of anemia by administration of recombinant human erythropoietin in a patient with aplastic anemia (1942534)Misago M.... Eto S.1991EPO
50Agranulocytosis, aplastic anemia, and leukemia: relevance to arachidonic acid metabolism. (2110677)Das U.N.1990EPO

Expression for genes affiliated with Aplastic Anemia

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Aplastic Anemia

Pathways for genes affiliated with Aplastic Anemia

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36QIAGEN, 20KEGG, 3Cell Signaling Technology, 37R&D Systems, 38Reactome
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Pathways related to aplastic anemia according to GeneDecks:

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idPathwayScoreTop Affiliating Genes
1RAR-Gamma-RXR-Alpha Degradation3610.4CSF3, CSF2, CSF1, IL11, IL12A, IL15
2Graft-versus-host disease2010.4CD28, FASLG, PRF1, HLA-B, HLA-A
3Lymphocyte Signaling310.3GATA2, GATA3, GATA1, GFI1B, SH2D1A, NFATC2
4IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types3710.2FASLG, IL15RA, IL15, IL2RA, CSF2, CCL3
5NFAT Signaling and Lymphocyte Interactions3610.1NFATC2, CCL3, ANGPT1, IL4, IL3, IL23A
6Telomerase Components in Cell Signaling369.9PRKCE, KITLG, THPO, IL3, FGF2, TINF2
7PGC1Alpha Pathway369.8IL1B, IL18, IL15, IL12B, IL12A, IL11
8Regulation of eIF4 and p70S6K369.6RPS6, IL11, ITGB3, ITGA2B, IL12A, IL12B
9IL-6 Pathway369.5IL10, IL11, IL12A, IL12B, IL18, IL23A
10Immune System389.5CD34, IL3, CSF2, CD79A, SAA1, VCAM1
11Jak-STAT signaling pathway209.4EPO, MPL, IL10, IL11, IL12A, IL12B
12Th1 Differentiation379.2IL10, GATA3, TBX21, TNF, IFNG, IL18
13THC Differentiation Pathway368.9HLA-DQB1, IL12B, IL2RA, HLA-DRB1, IFNG, IL4
14Autoimmune thyroid disease208.8CD28, CD40LG, IL10, FAS, HLA-A, HLA-B
15Measles208.7IL12B, CD28, MSN, SH2D1A, TP53, IFNG
16African trypanosomiasis208.6TNF, IFNG, FAS, FASLG, IL6, IL1B
17Cytokine Network368.6IFNG, IL10, IL6, IL4, IL3, IL1B
18Type I diabetes mellitus208.6FAS, FASLG, IL1B, IL12B, IL12A, INS
19Hematopoietic cell lineage208.6EPO, CSF3R, CSF3, CSF2RA, CSF2, CSF1
20Allograft rejection208.5TNF, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, IFNG
21IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types378.5TGFB1, IFNG, IL6, IL4, IL23R, IL23A
22IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types378.5IL10, TGFB2, TNF, FASLG, IL2RA, FAS
23Endothelin-1 Signaling Pathway368.4IL10, IL11, IL12A, IL12B, IL18, IL1B
24all-trans-Retinoic Acid Signaling in Brain368.2IL15, TNF, CSF1, CSF2, CSF3, CCL3
25MIF Mediated Glucocorticoid Regulation368.2IL11, ANGPT1, IL6, IL4, IL3, IL23A
26PEDF Induced Signaling368.2ANGPT1, IL10, IL11, IL12A, IL12B, IL15
27MIF Regulation of Innate Immune Cells368.2TNF, IL12B, CSF1, CSF2, CSF3, CCL3
28Amoebiasis208.1FN1, IL12A, IL1B, IL6, NOS2, TGFB1
29Akt Signaling368.0ITGA2B, FLT3, IL10, IL11, IL12B, IL15
30Pathways in cancer208.0ITGA2B, MTOR, VEGFA, FLT3LG, GSTP1, FLT3
31STAT3 Pathway367.9IL3, IL10, CD28, IL11, IL12A, IL2RA
32SOCS Pathway367.9CCL3, IL23A, IL3, IL12B, IL12A, IL11
33Molecular Mechanisms of Cancer367.9IL23R, IL3, IL6, ANGPT1, TP53, NRAS
34Intestinal immune network for IgA production207.8IL6, IL4, IL15, CD40LG, HLA-DQB1, HLA-DRB1
35Malaria207.8IL1B, IL18, IL12A, IL10, CD40LG, VCAM1
36Rho Family GTPases367.5CSF3, CSF2, CSF1, TGFB2, TGFB1, THPO
37Leishmaniasis207.5NOS2, IL12B, IL10, TNF, IL12A, IL1B
38TGF-Beta Pathway367.5NRAS, IL12B, IL12A, IL11, IL10, FGF2
39Glucocorticoid Receptor Signaling367.5IL11, IL10, TGFB1, CCL3, ANGPT1, IL6
40ERK Signaling367.4KITLG, THPO, TGFB1, TGFB2, PRKCE, CSF3
41JAK-STAT Pathway367.4EPO, TGFB2, TGFB1, THPO, NRAS, IFNG
42Rheumatoid arthritis207.4TGFB1, IL18, IL15, IL11, CD28, VEGFA
43Chagas disease (American trypanosomiasis)207.3TGFB2, TGFB1, TNF, CCL3, FAS, FASLG
44Tec Kinases Signaling367.2KITLG, CSF3R, CSF2RA, PRKCE, TGFB2, TGFB1
45MAPK Family Pathway367.1TGFB2, TGFB1, THPO, NRAS, TNF, CCL3
46PAK Pathway366.9ANGPT1, IL6, TNF, NRAS, THPO, TGFB1
47Tuberculosis206.7IL1B, IFNG, HLA-DQB1, HLA-DRB1, TNF, NOS2
48Antioxidant Action of Vitamin-C366.5IL2RA, CSF3R, IL3, IL4, IL6, ANGPT1
49Cytokine-cytokine receptor interaction206.4TGFB1, IL23A, IL1B, IL18, IL15RA, IL15
50p38 Signaling366.0IL12B, IL15, IL15RA, IL1B, IL23A, IL23R

Compounds for genes affiliated with Aplastic Anemia

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32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience, 18HMDB
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Compounds related to aplastic anemia according to GeneDecks:

(show top 50)    (show all 380)
idCompoundScoreTop Affiliating Genes
1cyclophosphamide32 34 9 9 13.8PIGA, FLT3LG, TRB@
2ionomycin32 10.7IL3, CCL3, NFATC2, CSF2, GATA3
3gp 13032 10.2MPL, FLT3, IL15, IL2RA, IL3, FAS
4agar32 10.1KITLG, CD40LG, CD34, FN1, FGF2, TERC
5h2o232 9.9KITLG, SDHB, CD79A, IL18, IL2RA, IL3
6pge232 9.9VCAM1, FOXP3, FN1, FGF2, IL23A, FASLG
7rapamycin32 42 10.5KITLG, NBN, VEGFA, MTOR, FOXP3, FN1
8methylcellulose32 9.5PIGA, KITLG, CD59, CD34, FLT3LG, FLT3
9cytarabine32 34 9 9 12.4KITLG, FLT3, IL11, IL3, FASLG, FAS
10aspartate32 9.3SDHB, CD40LG, CD55, IL11, IL18, FASLG
11ascorbic acid32 18 9.9SDHB, CD40LG, GSTM1, GSTP1, GSTT1, IL2RA
12sb 20358032 42 9.8VEGFA, VCAM1, FGF2, IL6, ANXA5, IFNG
13etoposide32 42 9 9 11.8FLT3, GSTP1, IL3, FASLG, FAS, ANXA5
14poly(i-c)32 8.6VCAM1, IL12B, IL15, IL18, IL1B, IL3
15rituximab32 34 9 9 11.6MTOR, CD79A, CD59, CD40LG, CD52, CD55
16histamine32 18 9.5KITLG, VCAM1, CD79A, CD40LG, CD55, IL11
175fluorouracil32 8.4KITLG, VEGFA, MTOR, MPL, GSTM1, GSTP1
18estrogen32 8.4SAA1, MSN, CD34, ITGB3, INS, GSTP1
19mycophenolate mofetil32 9 9 10.3CD79A, CD40LG, IL10, IL11, IL18, IL2RA
20zidovudine32 9 9 10.3KITLG, IL10, IL3, CCL3, ALB, HPRT1
21cysteine32 8.3SDHB, MPL, CD79A, CD40LG, CD55, ITGA2B
22doxorubicin32 34 9 9 11.2KITLG, NBN, MTOR, CD40LG, FN1, FLT3
23okt332 8.2VCAM1, CD79A, CD40LG, IL10, IL15, IL2RA
24butyrate32 7.9KITLG, CD55, FN1, GSTP1, IL11, IL18
25polyinosinic-polycytidylic acid32 7.8VCAM1, LGALS9, IL10, IL12B, IL15, IL18
26rantes32 7.6KITLG, VCAM1, CD40LG, IL11, IL12B, IL15
27hydrocortisone32 9 9 9.6KITLG, INS, FGF2, IL10, IL15, IL1B
28neopterin32 7.6CD79A, CD40LG, IL10, IL18, IL1B, IL2RA
29thalidomide32 42 9 9 10.5VEGFA, CD40LG, FGF2, IL10, IL11, IL18
30creatinine32 7.5KITLG, SDHB, CD79A, CD40LG, CD55, FN1
31infliximab32 9 9 9.4VEGFA, FGF2, IL10, IL11, IL15, IL18
32paclitaxel32 34 9 9 10.3KITLG, VEGFA, FN1, GSTP1, FGF2, IL11
33phosphatidylinositol32 7.3PIGA, KITLG, NBN, VCAM1, LGALS9, MTOR
34pd 98,05932 7.2KITLG, VCAM1, MTOR, FN1, FGF2, IL12B
35vitamin d32 7.0CD79A, ITGB3, FN1, GSTM1, IL10, IL11
36cisplatin32 34 9 9 10.0KITLG, VEGFA, MTOR, CD40LG, CD55, FN1
37vegf32 6.8KITLG, VCAM1, SDHB, MTOR, MPL, CD40LG
38tgf beta132 6.6KITLG, VCAM1, FOXP3, FN1, FLT3, FGF2
39testosterone32 9 18 9 9.5KITLG, VCAM1, SDHB, MTOR, CD79A, CD40LG
40paraffin32 6.5KITLG, VEGFA, VCAM1, CD79A, CD40LG, CD34
41tacrolimus32 34 9 9 9.5MTOR, CD28, CD79A, FN1, INS, IL10
42curcumin32 6.4VEGFA, VCAM1, GSTP1, IL15, IL18, IL1B
43methotrexate32 34 42 9 9 10.2KITLG, CD79A, GSTM1, GSTP1, IL10, IL15
44ly29400232 6.1VEGFA, FN1, FGF2, IL10, IL18, IL1B
45lactate32 5.7KITLG, VCAM1, SDHB, CD79A, CD59, CD40LG
46actinomycin d32 5.6KITLG, VEGFA, CD40LG, CD55, FN1, GSTP1
47alanine32 5.5KITLG, VCAM1, SDHB, SAA1, MSN, MPL
48retinoic acid32 42 18 7.2KITLG, VCAM1, MTOR, CD79A, CD40LG, CD34
49tyrosine32 4.9SH2D1A, PDCD1, KITLG, VEGFA, VCAM1, SDHB
50dexamethasone32 42 34 9 9 7.0KITLG, VEGFA, VCAM1, MTOR, SAA1, CD28

GO Terms for genes affiliated with Aplastic Anemia

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Sources:
12Gene Ontology
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Cellular components related to aplastic anemia according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1nuclear telomere cap complexGO:00078310.7TINF2, TERT, TERF2, TERF1
2chromosome, telomeric regionGO:00078110.6DCLRE1B, TINF2, TERT, TERF2, TERF1
3telomerase holoenzyme complexGO:00569710.5TERT, DKC1, WRAP53
4Cajal bodyGO:01503010.4GAR1, WRAP53, NHP2, DKC1, NOP10
5nucleolusGO:0057309.4RPL11, NFATC2, PUS1, DKC1, NHP2, WRAP53
6external side of plasma membraneGO:0098978.9FAS, ANXA5, IFNG, HLA-DRB1, TNF, CTLA4
7platelet alpha granule lumenGO:0310938.6TGFB2, TGFB1, PLG, ALB, FN1, VEGFA
8integral to plasma membraneGO:0058878.4HLA-A, HLA-B, HLA-DRB1, TNF, CTLA4, PLAUR
9cell surfaceGO:0099868.2TGFB2, TGFB1, PLAUR, CYP3A4, TNF, FLT3
10plasma membraneGO:0058866.8NRAS, CTLA4, TNF, HLA-DRB1, HLA-DQB1, HLA-B
11cytoplasmGO:0057376.3CYP3A4, PTPN22, TERT, TERF2, TERF1, TP53
12extracellular regionGO:0055765.8PLG, PLAUR, ALB, IFNG, CCL3, ANGPT1
13extracellular spaceGO:0056154.9EPO, IL6, FASLG, ANGPT1, CCL3, IFNG

Biological processes related to aplastic anemia according to GeneDecks:

(show top 50)    (show all 111)
idNameGO IDScoreTop Affiliating Genes
1telomere maintenanceGO:00072310.8DKC1, TINF2, DCLRE1B, TERT, TERF2, TERF1
2rRNA processingGO:00636410.8RPL35A, SBDS, RPS19, RPS6, GAR1, NOP10
3positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.7IL23R, IL23A, IL12B, IL12A
4embryonic hemopoiesisGO:03516210.6IL3, KITLG, GATA3, GATA1, FLT3LG
5negative regulation of interleukin-10 productionGO:03269310.6IL23R, IL23A, IL12B, FOXP3
6positive regulation of NK T cell activationGO:05113510.6IL12A, IL23R, IL23A, IL12B
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.5IL23A, IL23R, EPO, IL3, IL4, CSF2
8positive regulation of natural killer cell proliferationGO:03281910.4IL12B, IL15, IL18, IL23A, IL23R
9positive regulation of tissue remodelingGO:03410510.3IL23A, IL15, IL18, IL12B
10neutrophil chemotaxisGO:03059310.3SAA1, TGFB2, IL1B, CCL3, IFNG, CSF3R
11positive regulation of cell adhesionGO:04578510.3IL12B, IL12A, VEGFA, ANGPT1, IFNG, SAA1
12positive regulation of osteoclast differentiationGO:04567210.3IL12B, IL23R, IL23A, IFNG, TNF, CSF1
13dendritic cell differentiationGO:09702810.2FLT3, IL4, CSF2, GATA1
14positive regulation of activated T cell proliferationGO:04210410.2IL23R, IL4, IL23A, IL18, IL12B
15positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.2IL18, IL12B, IL1B, IL23A, IL23R
16positive regulation of interleukin-12 productionGO:03273510.2CD40LG, IL12B, IL23A, IL23R, IFNG
17positive regulation of interleukin-10 productionGO:03273310.2IL12B, IL23A, CD40LG, IL4, CD34
18cell proliferationGO:00828310.0GFI1B, THPO, TGFB2, DKC1, CSF1, KITLG
19humoral immune responseGO:00695910.0IFNG, GATA3, IL6, CD28, PDCD1, TNF
20hemopoiesisGO:0300979.9CD34, FLT3, IL10, ANGPT1, TGFB2, CSF1
21positive regulation of neuron apoptotic processGO:0435259.8TNF, NQO1, TGFB2, FASLG, IL18, CCL3
22viral infectious cycleGO:0190589.8TGFB1, RPS17, RPS24, RPS19, RPL35A, RPS6
23defense response to Gram-negative bacteriumGO:0508299.7IL23A, IL12B, NOS2, IL6, IL23R
24positive regulation of interferon-gamma productionGO:0327299.6TNF, IL23R, IL23A, IL12A, CD40LG, IL1B
25positive regulation of interleukin-17 productionGO:0327409.6TGFB1, IL23R, IL23A, IL18, IL15, IL12B
26B cell differentiationGO:0301839.5IL4, IL11, IL10, FLT3, CD40LG, CD79A
27positive regulation of MHC class II biosynthetic processGO:0453489.5IFNG, IL4, IL10, CD40LG
28positive regulation of T cell proliferationGO:0421029.4IL12B, IL23A, CD28, VCAM1, IL1B, IL23R
29cytokine-mediated signaling pathwayGO:0192219.3IFNG, VCAM1, IL1B, CSF3, HLA-DQB1, FLT3
30immune responseGO:0069559.2IL18, CSF2, HFE, NOTCH1, CTLA4, HLA-DRB1
31positive regulation of gene expressionGO:0106289.1TGFB1, PLAUR, CCL3, IL18, TGFB2, CD34
32signal transductionGO:0071658.9FLT3LG, T, GATA3, MTOR, LGALS9, KITLG
33positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8IL11, ITGB3, INS, IL3, IL6, KITLG
34lipopolysaccharide-mediated signaling pathwayGO:0316638.8PRKCE, IL18, IL1B, CCL3, TNF, TGFB1
35cell-cell signalingGO:0072678.8CCL3, TGFB2, IL10, FASLG, GATA1, IL18
36positive regulation of protein kinase B signaling cascadeGO:0518978.7TGFB1, GATA3, TNF, CCL3, ANGPT1, INS
37anti-apoptosisGO:0069168.6TNF, ANGPT1, EPO, FAS, TERT, IL10
38platelet degranulationGO:0025768.6ITGB3, ITGA2B, VEGFA, FN1, ALB, PLG
39positive regulation of peptidyl-serine phosphorylationGO:0331388.6IL11, VEGFA, IL6, ANGPT1, TNF, TGFB1
40MAPK cascadeGO:0001658.4CCL3, NRAS, TNF, IL1B, IL18, TGFB1
41positive regulation of cell proliferationGO:0082847.9EPO, IL11, FGF2, INS, TGFB2, FLT3
42positive regulation of protein phosphorylationGO:0019347.9VEGFA, MTOR, ITGB3, IL1B, CCND3, TNF
43response to hypoxiaGO:0016667.9TGFB1, NOS2, TNF, ANGPT1, FAS, VCAM1
44negative regulation of cell proliferationGO:0082857.7TGFB1, PLG, TNF, TP53, IL6, IL1B
45platelet activationGO:0301687.6CD40LG, ITGA2B, ITGB3, FN1, IL11, IL6
46positive regulation of transcription from RNA polymerase II promoterGO:0459447.5FOXP3, GATA2, GATA3, GATA1, PUS1, TGFB1
47negative regulation of apoptotic processGO:0430667.5PLAUR, INS, EPO, VEGFA, GATA1, CSF2
48inflammatory responseGO:0069547.5IL10, TGFB1, IL23A, IL15, CSF1, IL23R
49blood coagulationGO:0075967.0VEGFA, ITGB3, PLAUR, MPL, TGFB2, CD59
50positive regulation of transcription, DNA-dependentGO:0458937.0TBX21, TNF, TP53, IL6, IL4, IL1B

Molecular functions related to aplastic anemia according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1telomeric DNA bindingGO:04216210.6TERF1, TERF2, TERT, TINF2
2cytokine receptor activityGO:00489610.4CSF3R, CSF2RA, IL15RA, IL12B, FLT3, MPL
3interleukin-12 receptor bindingGO:00514310.4IL23R, IL12B, IL12A
4structural constituent of ribosomeGO:00373510.3RPS19, RPL5, RPS24, RPS17, RPL35A, RPS6
5RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010779.9GATA2, GATA3, GATA1, TP53, HNRNPK
6eukaryotic cell surface bindingGO:0434999.5CD48, ANXA5, TGFB1, EPO
7enzyme bindingGO:0198998.2CSF3, PRKCE, TGFB1, NOTCH1, PLAUR, CYP2E1
8growth factor activityGO:0080837.6CSF3, IL12A, IL11, IL10, FGF2, VEGFA
9cytokine activityGO:0051257.3CSF3, CSF2, CSF1, TGFB2, THPO, IL12A
10protein bindingGO:0055153.8PLG, NOP10, NOS2, NOTCH1, RPS6, RPL5

Sources for Aplastic Anemia

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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