MCID: APL001
MIFTS: 82

Aplastic Anemia malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases, Bone diseases categories
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Summaries for Aplastic Anemia

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8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Aplastic anemia is a rare but serious blood disorder. if you have it, your bone marrow doesn't make enough new blood cells. causes include being exposed to toxic substances, such as pesticides, arsenic, and benzene radiation therapy and chemotherapy for cancer certain medicines infections such as hepatitis, epstein-barr virus, or hiv autoimmune disorders certain inherited conditions in many people, the cause is unknown. your doctor will diagnose aplastic anemia based on your medical and family histories, a physical exam, and test results. once your doctor knows the cause and severity of the condition, he or she can create a treatment plan for you. treatments include blood transfusions, blood and marrow stem cell transplants, and medicines. nih: national heart, lung, and blood institute

MalaCards: Aplastic Anemia, also known as anemia aplastic, is related to paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes. An important gene associated with Aplastic Anemia is IFNG (interferon, gamma), and among its related pathways are Immune response IL 12 signaling pathway and Regulation of Telomerase. The drug carboplatin and the compounds daniplestim and molgramostim have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are skeleton and digestive/alimentary.

Disease Ontology:8 An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.

NIH Rare Diseases:43 Aplastic anemia is failure of the bone marrow to make enough blood cells. all blood cell types are affected. it can be caused by injury to blood stem cells due to exposure to certain drugs, chemotherapy, congenital disorders, drug therapy to suppress the immune system, pregnancy, radiation therapy, or toxins such as benzene or arsenic. when the cause is unknown, it is referred to as idiopathic aplastic anemia. in about half of all cases, no cause can be found. the condition can be acute or chronic. last updated: 8/21/2009

Wikipedia:65 Aplastic anemia is a disease in which the bone marrow, and the blood stem cells that reside there, are... more...

Description from OMIM:47 609135,614742,614743

Aliases & Classifications for Aplastic Anemia

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8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
idiopathic aplastic anemia:
Prevalence: 1-9/1000000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

aplastic anemia 8 9 43 47 10 34 31 62
anemia aplastic 43 22 45
idiopathic aplastic anemia 43 49
bone marrow diseases 34 62
aplastic anemia, idiopathic 62
aplastic anemia idiopathic 43
secondary aplastic anemia 43
bone marrow failure 49


External Ids:

Disease Ontology8 DOID:12449
NCIt40 C2870
MeSH35 D000741
ICD9CM27 284.9
MESH via Orphanet36 C538494
ICD10 via Orphanet26 D61.0
SNOMED-CT via Orphanet59 191256002
UMLS via Orphanet63 C0348890

Related Diseases for Aplastic Anemia

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17GeneCards, 18GeneDecks
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Diseases in the Aplastic Anemia family:

Aplastic Anemia, Ifng-Related Hereditary Aplastic Anemia

Diseases related to Aplastic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1paroxysmal nocturnal hemoglobinuria31.4PIGA, CSF3
2myelodysplastic syndromes31.3TERC, PIGA, FLT3LG, EPO, IL3, CSF2
3dyskeratosis congenita31.0TERC, DKC1
4leukemia31.0IL3, KITLG, CSF3, CSF2, IFNG, PIGA
5refractory anemia31.0KITLG, CSF3, EPO, IL3, CSF2
6myeloid leukemia30.8IL3, CSF2, TRB, KITLG, CSF3
7graft versus host disease30.7IL3, IFNG, CSF2, TRB, CSF3
8pancytopenia30.7DKC1, CSF3, CSF2, IL3, EPO
9neutropenia30.5KITLG, CSF3, SBDS, IL3, EPO, CSF2
10fanconi's anemia30.5IL3, KITLG, DKC1, TERC
11diamond-blackfan anemia30.5EPO, IL3
12thrombocytopenia30.5FLT3LG, PIGA, EPO, IL3, KITLG, CSF3
13severe congenital neutropenia autosomal recessive 330.2CSF2, IL3, CSF3
14felty's syndrome30.2CSF3, IL3, CSF2
15transient erythroblastopenia of childhood30.2KITLG, EPO
16t-cell large granular lymphocyte leukemia30.2TRB, CSF2
17myelofibrosis30.2IL3, EPO
18erythrocytosis30.2EPO, KITLG, IL3
19chronic myelomonocytic leukemia30.2KITLG, CSF2, CSF3
20hodgkin's lymphoma30.2CSF3, IL3, TRB, CSF2
21severe congenital neutropenia30.2IL3, CSF2, CSF3, KITLG
22leukopenia30.2FLT3LG, IL3, CSF2, CD52, CSF3
23chronic lymphocytic leukemia30.2TRB, CSF2, CD52
24acute lymphocytic leukemia30.2CSF2, CSF3, KITLG, IL3, TRB
25chronic myeloid leukemia30.1EPO, TRB, KITLG, IL3, CSF3, CSF2
26myeloma30.1KITLG, CSF3, IL3, CSF2, EPO, TRB
27deficiency anemia30.1KITLG, IL3, EPO, TERC, PIGA, CSF3
28rheumatoid arthritis30.1CSF2, TERT, IFNG, CD52, TRB
29acute leukemia30.0IL3, TRB, KITLG, TERT, FLT3LG, CSF3
30melanoma29.9FLT3LG, IFNG, PRF1, CSF2, TERT, KITLG
31hemoglobinuria10.8
32hematopoietic stem cell transplantation10.8
33inherited bone marrow failure syndromes10.8
34hepatitis10.8
35acute myeloid leukemia10.4
36bone marrow failure syndrome 210.4
37pure red-cell aplasia10.4
38purpura10.4
39hemochromatosis10.4
40cerebritis10.4
41congenital hypoplastic anemia10.4
42thymoma10.4
43pulmonary fibrosis10.3
44dyskeratosis congenita x-linked10.3
45bone marrow failure, familial10.3
46acute liver failure10.3
47pyomyositis10.3
48pseudotumor cerebri10.3
49systemic lupus erythematosus10.3
50aspergillosis10.3

Graphical network of the top 20 diseases related to Aplastic Anemia:



Diseases related to aplastic anemia

Symptoms for Aplastic Anemia

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47OMIM
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Symptoms by clinical synopsis from OMIM:

614743

Clinical features from OMIM:

609135,614742,614743

Drugs & Therapeutics for Aplastic Anemia

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42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Genetic Tests for Aplastic Anemia

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22GTR
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Genetic tests related to Aplastic Anemia:

id Genetic test Affiliating Genes
1 Aplastic Anemia22

Anatomical Context for Aplastic Anemia

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33MalaCards
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MalaCards organs/tissues related to Aplastic Anemia:

33
Bone, Bone marrow, T cells, Lung, Testes, Heart, Liver, Myeloid, Kidney, Colon, Skin, Monocytes, B cells, Endothelial, Thyroid, Thymus, Fetal liver

Animal Models for Aplastic Anemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Aplastic Anemia:

37 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.2TERT, TERC, PIGA, IFNG, SBDS, CSF2
2MP:00053819.2TERT, TERC, PIGA, IFNG, SBDS, TBX21
3MP:00053889.2TERC, DKC1, IFNG, IL3, CSF2, TBX21
4MP:00053799.2TERT, TERC, PRF1, IFNG, IL3, SBDS
5MP:00053809.2TERC, PIGA, EPO, DKC1, IFNG, SBDS
6MP:00053709.2EPO, PRF1, IFNG, SBDS, KITLG, TRB
7MP:00053899.1TERT, TERC, PIGA, PRF1, DKC1, IFNG
8MP:00028739.0TERT, EPO, PRF1, DKC1, IFNG, SBDS
9MP:00053859.0TERC, EPO, IFNG, SBDS, CSF2, TBX21
10MP:00036319.0TERC, PIGA, PRF1, IFNG, TBX21, KITLG
11MP:00053678.8DKC1, IFNG, IL3, CSF2, CSF3, TRB
12MP:00053788.7TERT, TERC, PIGA, PRF1, DKC1, IFNG
13MP:00053768.7TERT, TERC, EPO, PRF1, DKC1, IFNG
14MP:00107718.7TERC, PIGA, EPO, PRF1, DKC1, IFNG
15MP:00020068.7TERT, TERC, PIGA, PRF1, DKC1, IFNG
16MP:00053848.6PRF1, EPO, PIGA, TERC, TERT, DKC1
17MP:00107688.4PRF1, EPO, PIGA, TERC, TERT, DKC1
18MP:00053877.9IFNG, DKC1, PRF1, FLT3LG, TERC, TERT
19MP:00053977.5TRB, TERT, TERC, PIGA, FLT3LG, EPO

Publications for Aplastic Anemia

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52PubMed
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Articles related to Aplastic Anemia:

(show top 50)    (show all 842)
idTitleAuthorsYear
1
Allogeneic hematopoietic stem cell transplantation for children with severe aplastic anemia. (23724451)
2013
2
Respiratory and systemic infections in children with severe aplastic anemia on immunosuppressive therapy. (23836007)
2013
3
Long-term outcome of childhood aplastic anemia patients who underwent allogeneic hematopoietic SCT from an HLA-matched sibling donor in Japan. (23103680)
2013
4
Aplastic anemia following viral hepatitis. (24201921)
2013
5
Less could be better: the case for reducing the dose of cyclophosphamide for children undergoing allogeneic stem cell transplant for severe aplastic anemia. (23581860)
2013
6
In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantation: Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation. (23450467)
2013
7
Tcf-1 gene silence suppresses downstream gene expression in CD4(+) T cells from bone marrow of aplastic anemia patients. (21881822)
2012
8
Exome sequencing identifies MPL as a causative gene in familial aplastic anemia. (22180433)
2012
9
Aplastic anemia in association with a lymphoproliferative neoplasm: coincidence or causality? (21962338)
2012
10
Serum zinc and copper levels in aplastic anemia. (22796694)
2012
11
Eltrombopag in refractory aplastic anemia. (22992084)
2012
12
Long-term follow-up of clonal evolutions in 802 aplastic anemia patients: a single-center experience. (21207031)
2011
13
Comparison between matched related and alternative donors of allogeneic hematopoietic stem cells transplanted into adult patients with acquired aplastic anemia: multivariate and propensity score-matched analysis. (21220035)
2011
14
Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia. (21963603)
2011
15
Comparison of outcomes after transplantation of G-CSF-stimulated bone marrow grafts versus bone marrow or peripheral blood grafts from HLA-matched sibling donors for patients with severe aplastic anemia. (21034842)
2011
16
Transient aplastic anemia in Down's syndrome - a rare association. (21354344)
2011
17
A hospital-based case control study of aplastic anemia in Shanghai, China. (20026322)
2010
18
FDG-PET/CT in diagnosis and early response evaluation of extra-pulmonary tuberculosis in a patient with aplastic anemia. (20739773)
2010
19
Clinical course of non-severe aplastic anemia in adults. (20524094)
2010
20
Case of subcutaneous abscess caused by Nocardia farcinica in an aplastic anemia patient. (20467197)
2010
21
Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia. (20118992)
2010
22
Telomerase gene mutation screening in Chinese patients with aplastic anemia. (19942288)
2010
23
Outcomes of matched sibling and alternative donor stem cell transplantation for 26 children with severe aplastic anemia. (20037749)
2010
24
A novel cell-based therapy for patients with aplastic anemia. (20429786)
2010
25
TINF2 mutations in children with severe aplastic anemia. (19090550)
2009
26
Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma. (19109204)
2009
27
Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bone marrow transplantation from unrelated donors: results of matched pair analysis. (19896085)
2009
28
Changes in cytokine profile pre- and post-immunosuppression in acquired aplastic anemia. (19586939)
2009
29
Treatment of severe aplastic anemia by immunosuppressor anti-lymphocyte globulin/anti-thymus globulin as the chief medicine in combination with Chinese drugs. (19407954)
2009
30
Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia: recommendations for a standardized approach. (19144661)
2009
31
Hematopoietic growth factors in aplastic anemia patients treated with immunosuppressive therapy-systematic review and meta-analysis. (19336743)
2009
32
Feasibility and eligibility of retreatment with rabbit anti-T lymphocyte globulin for aplastic anemia previously treated with horse anti-thymocyte globulin. (19728019)
2009
33
Increased CD4+ and CD8+ effector memory T cells in patients with aplastic anemia. (19181780)
2009
34
Alterations in hematopoietic microenvironment in patients with aplastic anemia. (20443870)
2009
35
Impaired expression of genes regulating homeostasis of stem hemopoietic cells in stromal cells of patients with aplastic anemia]. (18326231)
2008
36
Clinical implications of combined measurement bone marrow T cells intracellular IFNgamma and HLA-DRB1*1501 measurement in predicting the response to immunosuppressive therapy for aplastic anemia]. (18218241)
2007
37
Correlation of HLA-alleles with aplastic anemia]. (18088468)
2007
38
Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients. (16079101)
2005
39
Expression of interferon-gamma and tumor necrosis factor-alpha in bone marrow T cells and their levels in bone marrow plasma in patients with aplastic anemia. (15815907)
2005
40
The TNF2 allele is a risk factor to severe aplastic anemia independent of HLA-DR. (12941546)
2003
41
Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy. (12624493)
2003
42
Sustained long-term complete remission in an elderly aplastic anemia patient after cessation of combined therapy consisting of granulocyte-colony stimulating factor and erythropoietin]. (10695398)
2000
43
Aplastic anemia and paroxysmal nocturnal hemoglobinuria: a follow-up study of the glycosylphosphatidylinositol-anchored proteins defect. (11920198)
2000
44
Aplastic anemia in pregnancy: treatment with cyclosporine and granulocyte-colony stimulating factor. (10326895)
1999
45
Treatment of severe aplastic anemia with an immunosuppressive agent plus recombinant human granulocyte-macrophage colony-stimulating factor and erythropoietin. (9798655)
1998
46
Sweet syndrome in a child with aplastic anemia receiving recombinant granulocyte colony-stimulating factor. (8689342)
1996
47
In vitro effect of stem cell factor on colony growth from acquired severe aplastic anemia. (7691324)
1993
48
Myelodysplasia and leukemia after treatment of aplastic anemia with G-CSF. (1373226)
1992
49
Correlation of response of aplastic anemia patients to antilymphocyte globulin with in vitro lymphocyte stimulatory effect: predictive value of in vitro test for clinical response. (2029581)
1991
50
Use of hematopoietic growth factors for treatment of aplastic anemia. (2285123)
1990

Variations for Aplastic Anemia

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Aplastic Anemia:

1 (show all 34)
id Gene Name Type Significance SNP ID Assembly Location
1TERTNM_198253.2(TERT): c.604G> A (p.Ala202Thr)single nucleotide variantPathogenicrs121918661GRCh37Chr 5, 1294397: 1294397
2TERTNM_198253.2(TERT): c.1234C> T (p.His412Tyr)single nucleotide variantPathogenicrs34094720GRCh37Chr 5, 1293767: 1293767
3TERTNM_198253.2(TERT): c.2080G> A (p.Val694Met)single nucleotide variantPathogenicrs121918662GRCh37Chr 5, 1279456: 1279456
4TERTNM_198253.2(TERT): c.2315A> G (p.Tyr772Cys)single nucleotide variantPathogenicrs121918663GRCh37Chr 5, 1272367: 1272367
5TERTNM_198253.2(TERT): c.3268G> A (p.Val1090Met)single nucleotide variantPathogenicrs121918664GRCh37Chr 5, 1254510: 1254510
6PRF1NM_001083116.1(PRF1): c.1163G> T (p.Ser388Ile)single nucleotide variantPathogenicrs193302875GRCh37Chr 10, 72358314: 72358314
7PRF1NM_001083116.1(PRF1): c.11G> A (p.Arg4His)single nucleotide variantPathogenicrs35418374GRCh37Chr 10, 72360648: 72360648
8SBDSNM_016038.2(SBDS): c.258+2T> Csingle nucleotide variantPathogenic, risk factorrs113993993GRCh37Chr 7, 66459197: 66459197
9TERCTERC, 143G-Asingle nucleotide variantPathogenic
10TERCTERC, 212C-Gsingle nucleotide variantPathogenic
11TINF2NM_001099274.1(TINF2): c.862T> C (p.Phe288Leu)single nucleotide variantPathogenicrs199422317GRCh37Chr 14, 24709824: 24709824
12TERTNM_198253.2(TERT): c.2147C> T (p.Ala716Val)single nucleotide variantPathogenicrs199422298GRCh37Chr 5, 1278895: 1278895
13TERTNM_198253.2(TERT): c.2537A> G (p.Tyr846Cys)single nucleotide variantPathogenicrs199422302GRCh37Chr 5, 1268680: 1268680
14TERTNM_198253.2(TERT): c.2628C> G (p.His876Gln)single nucleotide variantPathogenicrs199422303GRCh37Chr 5, 1266605: 1266605
15TERTNM_198253.2(TERT): c.3043T> C (p.Cys1015Arg)single nucleotide variantPathogenicrs199422307GRCh37Chr 5, 1255516: 1255516
16TERTNM_198253.2(TERT): c.3184G> A (p.Ala1062Thr)single nucleotide variantPathogenic, risk factorrs35719940GRCh37Chr 5, 1254594: 1254594
17TERTNM_198253.2(TERT): c.835G> A (p.Ala279Thr)single nucleotide variantPathogenicrs61748181GRCh37Chr 5, 1294166: 1294166
18TERCNR_001566.1(TERC): n.117A> Csingle nucleotide variantPathogenicrs199422273GRCh37Chr 3, 169482732: 169482732
19TERCNR_001566.1(TERC): n.178G> Asingle nucleotide variantPathogenicrs199422275GRCh37Chr 3, 169482671: 169482671
20TERCNR_001566.1(TERC): n.180C> Tsingle nucleotide variantPathogenicrs199422276GRCh37Chr 3, 169482669: 169482669
21TERCNR_001566.1(TERC): n.28_34delGTGGTGGdeletionPathogenicrs199422259GRCh37Chr 3, 169482815: 169482821
22TERCNR_001566.1(TERC): n.305G> Asingle nucleotide variantPathogenicrs199422279GRCh37Chr 3, 169482544: 169482544
23TERCNR_001566.1(TERC): n.322G> Asingle nucleotide variantPathogenicrs199422280GRCh37Chr 3, 169482527: 169482527
24TERCNR_001566.1(TERC): n.323C> Tsingle nucleotide variantPathogenicrs199422281GRCh37Chr 3, 169482526: 169482526
25TERCNR_001566.1(TERC): n.391_392delCCdeletionPathogenicrs199422283GRCh37Chr 3, 169482457: 169482458
26TERCNR_001566.1(TERC): n.450G> Asingle nucleotide variantPathogenicrs199422287GRCh37Chr 3, 169482399: 169482399
27NBNNM_002485.4(NBN): c.511A> G (p.Ile171Val)single nucleotide variantPathogenic, Uncertain significance, risk factorrs61754966GRCh37Chr 8, 90990521: 90990521
28TERCNR_001566.1(TERC): n.204C> Gsingle nucleotide variantPathogenicrs199422277GRCh37Chr 3, 169482645: 169482645
29TERCNR_001566.1(TERC): n.58G> Asingle nucleotide variantPathogenicrs113487931GRCh37Chr 3, 169482791: 169482791
30TERCNR_001566.1(TERC): n.72C> Gsingle nucleotide variantPathogenicrs199422265GRCh37Chr 3, 169482777: 169482777
31TERCNR_001566.1(TERC): n.110_113delGACTdeletionPathogenicrs199422270GRCh37Chr 3, 169482736: 169482739
32TERCNR_001566.1(TERC): n.116C> Tsingle nucleotide variantPathogenicrs199422272GRCh37Chr 3, 169482733: 169482733
33TERCNR_001566.1(TERC): n.98G> Asingle nucleotide variantPathogenicrs199422268GRCh37Chr 3, 169482751: 169482751
34TERCTERC, 325G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Aplastic Anemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aplastic Anemia

Search GEO for disease gene expression data for Aplastic Anemia.

Pathways for genes affiliated with Aplastic Anemia

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 5Cell Signaling Technology, 30KEGG, 54R&D Systems, 53QIAGEN
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Pathways related to Aplastic Anemia according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IFNG, PRF1
29.9IFNG, DKC1, TERT
39.9IFNG, CSF2, TBX21
4
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.9CD3D, IFNG, PRF1
59.9KITLG, TBX21, IL3
69.9NOP10, SBDS, DKC1
7
Show member pathways
9.9CD3D, CSF2, IFNG
8
Show member pathways
Immune response CD16 signaling in NK cells60
9.8PRF1, IFNG, IL3, CSF2
9
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.8IFNG, IL3, CSF2, TBX21
10
Show member pathways
9.8PRF1, IFNG, IL3, CD3D
119.7PRF1, IFNG, TBX21, CD3D
129.6EPO, IL3, CSF3, KITLG
13
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.6IFNG, TBX21, CD3D, TRB
14
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.5IFNG, CSF2, CD3D, TRB
159.5IFNG, CSF2, CSF3, TRB
16
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.5EPO, KITLG, CD3D, TRB
17
Show member pathways
Type III interferon signaling38
9.5CSF3, CSF2, IL3, IFNG, EPO
18
Show member pathways
9.4IL3, CSF2, CSF3, KITLG, CD3D
198.9CD3D, FLT3LG, EPO, IL3, CSF2, CSF3
20
Show member pathways
8.7FLT3LG, EPO, IFNG, IL3, CSF2, CSF3

Compounds for genes affiliated with Aplastic Anemia

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 3BitterDB, 29IUPHAR
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Compounds related to Aplastic Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1daniplestim4510.2IL3, CSF3, KITLG
2molgramostim4510.2CSF3, CSF2, IL3
3carboxymethylcellulose4510.2EPO, KITLG, CSF3
4mesna4510.2IL3, CSF2, CSF3
5il 114510.2IL3, CSF3, EPO
6thiotepa45 51 1112.2IL3, CSF3, CSF2
7ara-ctp4510.2CSF3, CSF2, IL3
8lenalidomide45 1111.1EPO, CSF3, IL3
9pseudouridine45 2411.1DKC1, TERC, NOP10
10pegfilgrastim45 1111.1EPO, IL3, CSF2, CSF3
11mafosfamide4510.1IL3, CSF2, CSF3, KITLG
124-hydroperoxycyclophosphamide4510.0KITLG, CSF2, CSF3, IL3
13mycophenolate mofetil45 51 1112.0IL3, IFNG, CSF3, EPO
14amphotericin b4510.0IFNG, CSF2, CSF3
15alemtuzumab45 1111.0PIGA, CSF3, CD52
16as 10145 6110.9CSF2, IL3, KITLG
17rhodamine 12345 5110.9FLT3LG, KITLG, IL3
18ganciclovir45 1110.9TERT, KITLG, CSF3, CSF2
19daunorubicin45 51 1111.9KITLG, CSF3, CSF2, IL3
205-aza-2deoxycytidine459.9TERT, KITLG, IL3, EPO, IFNG
21hydrocortisone45 3 61 1112.9CSF2, KITLG, IL3, EPO, IFNG
22ribavirin45 51 1111.9IFNG, IL3, CSF2, CSF3, EPO
23melphalan45 51 1111.9CSF3, CSF2, IL3, IFNG, EPO
24amifostine45 1110.9EPO, CSF3, IL3, CSF2, KITLG
25filgrastim45 1110.9CSF2, IL3, EPO, CSF3, KITLG
26agar459.8KITLG, CSF2, TERC, PRF1, IL3
27idarubicin51 45 1111.8CSF3, CSF2, IL3
28hydroxyurea45 51 1111.8IL3, KITLG, EPO, CSF2, CSF3
29gp 130459.8KITLG, CSF3, CSF2, IL3, EPO
30cytarabine45 51 1111.8KITLG, CSF2, IL3, EPO, CSF3
31calcitriol45 61 24 1112.8IFNG, TERT, CSF2, IL3, EPO, KITLG
32etoposide45 51 61 1112.8CSF2, TERT, IL3, CSF3, TERC
33rantes459.7CSF3, KITLG, CSF2, IL3, IFNG
34adriamycin459.7TERC, TERT, IL3, CSF3
35gm-csf45 2910.7EPO, IFNG, KITLG, IL3, CSF2, CSF3
36carboplatin45 51 1111.7CSF3, IL3, EPO, IFNG, CSF2, KITLG
37doxorubicin45 51 1111.7CSF3, CSF2, IL3, TERC, TERT, KITLG
38butyrate459.6IFNG, EPO, TERC, IL3, TERT, CSF2
395fluorouracil459.6KITLG, CSF2, IL3, IFNG, TERC, CSF3
40pixy321459.6CSF3, IL3, CSF2, FLT3LG, KITLG, EPO
41zidovudine45 51 1111.5CSF3, TERC, TERT, EPO, IL3, CSF2
42cycloheximide459.5CSF2, KITLG, CSF3, IL3, IFNG, PRF1
43cisplatin45 51 61 1112.5CSF2, CSF3, KITLG, TERT, TERC, EPO
44cyclosporin a45 29 6111.4IFNG, IL3, CSF3, TRB, EPO, KITLG
45vegf459.3IFNG, CSF3, EPO, FLT3LG, TERT, CSF2
46rapamycin459.3KITLG, TERT, IFNG, IL3, EPO
47cyclophosphamide45 51 1111.3CSF3, CSF2, KITLG, FLT3LG, IL3, TRB
48methylcellulose459.2EPO, IFNG, IL3, CSF2, CSF3, KITLG
49thymidine45 2410.1TERT, TERC, FLT3LG, IL3, CSF3, CSF2
50retinoic acid45 2410.1IFNG, CSF3, KITLG, TERC, TERT, IL3

GO Terms for genes affiliated with Aplastic Anemia

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Sources:
16Gene Ontology
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Cellular components related to Aplastic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1telomerase holoenzyme complexGO:0056979.8TERT, DKC1
2extracellular regionGO:0055769.4KITLG, CSF2, IL3, IFNG, PRF1, EPO
3extracellular spaceGO:0056158.9KITLG, CSF3, CSF2, IL3, IFNG, EPO

Biological processes related to Aplastic Anemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of isotype switching to IgG isotypesGO:04830410.3IFNG, TBX21
2positive regulation of interleukin-23 productionGO:03274710.3CSF2, IFNG
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.1CSF2, IL3, EPO
4telomere maintenance via telomeraseGO:00700410.1DKC1, TERT
5embryonic hemopoiesisGO:03516210.1FLT3LG, IL3, KITLG
6T cell differentiationGO:03021710.1CD3D, TBX21
7positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.0KITLG, CSF3, IL3
8rRNA processingGO:00636410.0DKC1, SBDS, NOP10
9cellular response to lipopolysaccharideGO:07122210.0CSF3, CSF2, IFNG
10pseudouridine synthesisGO:00152210.0NOP10, DKC1
11positive regulation of DNA replicationGO:0457409.9KITLG, CSF2, IL3, EPO
12positive regulation of Ras protein signal transductionGO:0465799.8KITLG, EPO
13positive regulation of cell proliferationGO:0082849.6CSF3, CSF2, IL3, EPO, FLT3LG

Molecular functions related to Aplastic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1telomerase activityGO:00372010.1DKC1, TERT
2growth factor activityGO:0080839.3IL3, CSF2, CSF3, KITLG
3cytokine activityGO:0051259.1KITLG, CSF3, CSF2, IL3, IFNG, FLT3LG

Products for genes affiliated with Aplastic Anemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aplastic Anemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet