Apnea malady

Wikipedia: Apnea, apnoea, or apnœa (Greek: απνοια, from α-, privative, πνεειν, to breathe) is a term...⁴⁴ more...

MalaCards: Apnea is related to sleep apnea and hypertension. An important gene associated with Apnea is CHAT (choline O-acetyltransferase), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and Neuroactive ligand-receptor interaction. The drugs aminophylline and theophylline and the compounds bromocriptine and phenylephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and adipocyte, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

apnea 7 43

Diseases related to apnea by text searches and GeneDecks gene sharing:

(show top 50)    (show all 981)

id	Related Disease	Score	Top Affiliating Genes
1	sleep apnea	39.8	RETN, LEP, GHR, LSL, HCRT, TSPO
2	hypertension	34.2	REN, KCNMB1, GNB3, NOS2, NOS3, ACE
3	insulin resistance	32.1	LEPR, UCP2, IRS1, INS, SOD1
4	congestive heart failure	31.3	REN, APLN, FABP3, HMGCR, EDN1, EDNRA
5	polycystic ovary syndrome	29.9	LEP, IRS1, INS, IGF2, IGFBP3, IGF1
6	narcolepsy	29.2	LEP, INS, APOE, FABP3, CCL2, IGFBP3
7	congenital central hypoventilation syndrome	28.3	RET, BDNF, ASCL1, PHOX2B, EDN3, GDNF
8	retinol binding protein	28.3	RETN, RBP4, NAMPT, LEP, IRS1, INS
9	sleep disorder	27.7	VCAM1, LEP, INS, IL6, IL8, APOE
10	familial partial lipodystrophy	27.5	LMNA, LEP, INS, PPARG
11	poliomyelitis	27.5	CHAT, CD40LG, IL10, IL4, ICAM1, TNF
12	congenital myasthenic syndrome	27.3	CHAT, CD79A, CD40LG, MMP9, INS, IL10
13	gliosis	26.6	CHAT, S100B, IL6, ENO2, CRP, HCRT
14	pharyngitis	26.2	PCNA, BDNF, BCHE, CD79A, MMP9, ENO2
15	hemophilia	26.1	VWF, SELP, CD40LG, IL10, IL1B, IL4
16	fatty liver disease	26.1	RETN, RBP4, SERPINE1, NAMPT, LPL, LEP
17	tonsillitis	26.1	BDNF, CD79A, CD40LG, IL10, IL4, ENO2
18	sudden infant death syndrome	25.9	RET, CHAT, ASCL1, IL10, IL1B, IL4
19	aldosteronism	25.9	REN, RETN, SERPINE1, NAMPT, MMP9, IRS1
20	lipodystrophy	25.9	RETN, RBP4, SERPINE1, NAMPT, LPL, LMNA
21	obesity, association with	25.6	RETN, VWF, RBP4, SERPINE1, NAMPT, LEP
22	acromegaly	25.6	RETN, RBP4, SERPINE1, NAMPT, LPL, LEP
23	papilloma	25.6	RET, PCNA, BAX, S100B, MSX2, FGFR3
24	obesity	25.1	REN, RETN, VWF, PCNA, RBP4, SELE
25	uremia	24.3	REN, RET, RETN, VWF, SERPINE1, LPL
26	homocysteine	23.7	REN, RETN, VWF, PCNA, SELE, SELP
27	essential hypertension	22.9	REN, RETN, VWF, SELE, SELP, SERPINE1
28	coronary heart disease	22.1	RETN, VWF, SELE, SELP, SERPINE1, NAMPT
29	hypoxia	21.8	NDN, REN, RET, VWF, PCNA, SELE
30	blindness	19.4	REN, VWF, RBP4, SELE, SELP, SERPINE1
31	myocardial infarction	19.3	REN, RETN, VWF, SELE, SELP, SERPINE1
32	neuronitis	18.4	NDN, REN, RET, RETN, VWF, PCNA
33	atherosclerosis	18.2	REN, RETN, VWF, PCNA, RBP4, SELE
34	eating disorder	14.3	RETN, BDNF, LEP, LEPR, MC4R, CCKAR
35	heart valve disease	14.2	APOH, HTR2A, HTR3A, NPPA, NPPB
36	enuresis	14.2	REN, HTR2A, NOS3, NPPA, NPPB, ADM
37	congenital heart defect	14.1	HSPA1A, PF4, EDN1, EDNRA, NPPA, NPPB
38	aortic coarctation	14.1	GNB3, NOS3, EDN1, ACE, AGT, AGTR1
39	premature ejaculation	14.1	LEP, HTR1B, HTR2C, HTR3A, LSL, SLC6A4
40	hypothyroidism	14.1	RETN, LEP, APOB, IGFBP3, LSL, PON1
41	morbid obesity	14.1	RETN, LPL, LEP, LEPR, INS, MC3R
42	seasonal affective disorder	14.0	HTR2A, HTR2C, GNB3, NPY, SLC6A4, GABBR1
43	syncope	14.0	REN, GNB3, NOS3, EDN1, EDNRA, ACE
44	hirschsprung's disease	14.0	RET, BCHE, NTRK1, PHOX2B, EDN3, NPY
45	migraine with aura	14.0	HTR1B, HTR2A, HTR2C, NOS3, EDN1, EDNRA
46	pulmonary hypertension	14.0	HTR1B, HTR3A, NOS2, NOS3, EDN1, EDN3
47	generalized anxiety disorder	14.0	HTR2A, HTR2C, HTR3A, TSPO, NPY, SLC6A4
48	bronchitis	14.0	LEP, SAA1, MC4R, TF, TAC1, CP
49	progressive supranuclear palsy	14.0	BCHE, CHAT, APOE, APOH, HTR3A, HCRT
50	renal hypertension	14.0	REN, EDN1, ACE, KNG1, ADM

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 aminophylline, aminophylline dihydrate, aminophylline pwdr [va product], caffeine, citrated caffeine, oxtriphylline, theophylline, theophylline calcium salicylate, theophylline sodium glycinate, theophylline,anhydrous

MalaCards organs/tissues related to apnea:

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MGI Mouse Phenotypes related to apnea:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	NDN, RET, SELP, LPL, BDNF, LEPR
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	RET, UCN3, MSX1, MSX2, CD40LG, FMR1
3	embryogenesis phenotype	MP:0005380	10.3	RET, MSX1, MSX2, FGFR1, FGFR2, FDFT1
4	hematopoietic system phenotype	MP:0005397	10.2	PCNA, MSX2, FGFR2, FGFR3, IGF2, HLA-C
5	pigmentation phenotype	MP:0001186	9.7	LMNA, LEP, MSX2, ASCL1, FGFR2, APOB
6	liver/biliary system phenotype	MP:0005370	9.4	RETN, LPL, CHKA, UCN3, IRS1, INS
7	integument phenotype	MP:0010771	9.0	NDN, SELP, BDNF, LEPR, S100B, MSX1
8	adipose tissue phenotype	MP:0005375	9.0	RETN, SERPINE1, LPL, LMNA, LEP, LEPR
9	no phenotypic analysis	MP:0003012	8.7	NDN, RET, PCNA, VCAM1, BDNF, LEPR
10	immune system phenotype	MP:0005387	8.6	REN, VWF, SELP, LMNA, LEPR, UCP2
11	digestive/alimentary phenotype	MP:0005381	8.3	RET, VWF, LMNA, BDNF, LEP, LEPR
12	tumorigenesis	MP:0002006	8.3	RET, SERPINE1, LEP, LEPR, MMP9, FGFR2
13	nervous system phenotype	MP:0003631	8.3	NDN, REN, VWF, SELP, LMNA, BDNF
14	hearing/vestibular/ear phenotype	MP:0005377	8.2	LMNA, BDNF, KCNMB1, BAX, SALL1, MSX1
15	renal/urinary system phenotype	MP:0005367	7.8	REN, RET, SELP, LMNA, KCNMB1, LEPR
16	reproductive system phenotype	MP:0005389	7.7	REN, RET, RBP4, LMNA, BCHE, LEP
17	skeleton phenotype	MP:0005390	7.7	LMNA, LEP, LEPR, CHAT, BAX, SALL1
18	limbs/digits/tail phenotype	MP:0005371	7.6	RET, LMNA, LEP, BAX, SALL1, MSX1
19	behavior/neurological phenotype	MP:0005386	7.4	NDN, REN, SELE, SELP, LMNA, BDNF
20	muscle phenotype	MP:0005369	7.4	NDN, REN, RET, RBP4, LPL, LMNA
21	vision/eye phenotype	MP:0005391	7.0	RBP4, SELE, SELP, LMNA, BDNF, LEP
22	growth/size phenotype	MP:0005378	6.9	REN, RET, SELE, SELP, SERPINE1, LPL
23	normal phenotype	MP:0002873	6.7	NDN, REN, RET, RBP4, SELE, LMNA
24	mortality/aging	MP:0010768	6.7	NDN, REN, RET, VWF, SELE, SELP
25	cardiovascular system phenotype	MP:0005385	5.7	REN, RET, VWF, RBP4, SELE, SELP
26	cellular phenotype	MP:0005384	4.9	NDN, RET, VWF, PCNA, RBP4, SELE
27	homeostasis/metabolism phenotype	MP:0005376	4.7	NDN, REN, RET, RETN, VWF, RBP4

Articles related to apnea:

(show top 50)    (show all 280)

id	Title	Authors	Year	Affiliating Genes
1	Effect of cardiac rehabilitation on inflammatory mark ers in patients with high risk for obstructive sleep apnea: a pilot study. (21574823)	Parker A.T.... Sharma S.	2011	CCL2
2	Roles of hypertension and serum leptin in obstructiv e sleep apnea hypopnea syndrome (20450544)	Huang R.... Huang X.Z.	2010	LSL
3	Growth hormone/insulin-like growth factor-I axis in o bstructive sleep apnea syndrome: an update. (20418654)	Lanfranco F.... Maccario M.	2010	IGF1, GH1
4	A double-blind, crossover study of Doxazosin and Enal april on peripheral vascular tone and nocturnal blood pressure in sleep apnea p atients. (20171140)	Zou D.... Hedner J.	2010	ACE
5	Study of the relationship between the interleukin-6 g ene and obstructive sleep apnea. (21207764)	Larkin E.K.... Redline S.	2010	IL6
6	Reduction of serum retinol-binding protein-4 levels i n nondiabetic obstructive sleep apnea patients under continuous positive airway pressure treatment. (20224248)	Nena E.... Bouros D.	2010	RBP4
7	The influence of obstructive sleep apnea on the expre ssion of glycerol-3-phosphate dehydrogenase 1 gene. (20404019)	Guindalini C.... Tufik S.	2010	GPD1
8	Visceral obesity is associated with the metabolic syndrome and elevated plasma retinol binding protein-4 level in obstructive sleep apnea syndrome. (19003725)	Makino S.... Sugimoto T.	2009	RBP4, INS
9	Reciprocal interactions of obstructive sleep apnea an d hypertension associated with ACE I/D polymorphism in males. (19482546)	Koyama R.G.... Pedrazzoli M.	2009	ACE
10	Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome. (19288024)	Zhang X.... Zhang H.T.	2009	IL6
11	Iron stores, periodic leg movements, and sleepiness i n obstructive sleep apnea. (20465018)	O'Brien L.M.... Chervin R.D.	2009	TF
12	Ampakine CX717 protects against fentanyl-induced resp iratory depression and lethal apnea in rats. (19461299)	Ren J.... Greer J.J.	2009	OPRM1
13	Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea. (19127383)	CuhadaroA9lu C.... Ece T.	2009	LEP
14	Lack of association of the APOE epsilon 4 allele with the risk of obstructive sleep apnea: meta-analysis and meta-regression. (19928390)	Thakre T.P.... Kulkarni H.	2009	APOE
15	Comparison of serum adiponectin and tumor necrosis factor-alpha levels between patients with and without obstructive sleep apnea syndrome. (18487876)	Kanbay A.... Bukan N.	2008	TNF
16	Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea-hypopnea syndrome. (18198351)	Nakagawa Y.... Funahashi T.	2008	ADIPOQ
17	Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea. (18365276)	Kapsimalis F.... Gourgoulianis K.	2008	LEP, CRP
18	Apnea in a child after oral codeine: a genetic varian t - an ultra-rapid metabolizer. (17564651)	Voronov P.... Jagannathan N.	2007	CYP2D6
19	Effect of continuous positive airway pressure treatment on serum cardiovascular risk factors in patients with obstructive sleep apnea-hypopnea syndrome. (17573492)	Steiropoulos P.... Bouros D.	2007	APOA1, APOB
20	The APOE epsilon4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea. (18083630)	Cosentino F.I.... Ferri R.	2007	APOE
21	Efficacy of mirtazapine in obstructive sleep apnea syndrome. (17310863)	Carley D.W.... Radulovacki M.	2007	HTR3A
22	Determination of butyrylcholinesterase (BChE) phenotypes to predict the risk of prolonged apnea in persons receiving succinylcholine in the healthy population of western Iran. (17350607)	Vaisi-Raygani A.... Pourmotabbed T.	2007	BCHE
23	Nocturnal oxygen therapy prevents progress of congestive heart failure with central sleep apnea. (16806535)	Shigemitsu M.... Katagiri T.	2007	NOS3, NPPB, NPPA
24	Abnormally increased endothelin-1 in plasma during the night in obstructive sleep apnea: relation to blood pressure and severity of disease. (17198911)	GjA... Pedersen E.B.	2007	REN, AGT
25	Association of GABA(B)R1 receptor gene polymorphism with obstructive sleep apnea syndrome. (17264536)	Bayazit Y.A.... Ileri F.	2007	GABBR1
26	Microarray studies of genomic oxidative stress and cell cycle responses in obstructive sleep apnea. (17511582)	Hoffmann M.S.... Somers V.K.	2007	HMOX1, EIF4EBP2
27	The effect of nasal continuous positive airway pressure on endothelial function in obstructive sleep apnea-hypopnea syndrome with coronary heart disease (16624147)	Zhang J.... Ma Z.Y.	2006	EDN1
28	Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak. (16374834)	Larkin E.K.... Hallmayer J.	2006	APOE
29	Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea syndrome. (15764749)	Tatsumi K.... Kuriyama T.	2005	LEP
30	Association study of sleep apnea syndrome and polymorphisms in the serotonin transporter gene (16215942)	Yue W.H.... Ni M.	2005	SLC6A4
31	Symptoms of obstructive sleep apnea in patients with nonalcoholic fatty liver disease. (16416185)	Singh H.... Minuk G.Y.	2005	INS
32	Elevated C-reactive protein levels and increased cardiovascular risk in patients with obstructive sleep apnea syndrome. (16272771)	Kokturk O.... Ciftci B.	2005	CRP
33	The interleukin-6 level in exhaled breath condensate of patients with obstructive sleep apnea-hypopnea syndrome]. (16008970)	Qiao H.... Ding C.M.	2005	IL6
34	Effects of nasal continuous positive airway pressure on serum leptin concentration and the metabolic parameters in obstructive sleep apnea hypopnea syndrome (15171555)	Huang R.... Xiao Y.	2004	LSL
35	Interleukin-6 and tumor necrosis factor-alpha in patients with obstructive sleep apnea-hypopnea syndrome. (14872107)	Imagawa S.... Nagasawa T.	2004	TNF
36	Clinical significance of daytime plasma orexin-A-like immunoreactivity concentrations in patients with obstructive sleep apnea hypop nea syndrome. (15316212)	Sakurai S.... Takahashi K.	2004	HCRT
37	Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. (12615790)	Yokoe T.... Adachi M.	2003	CRP
38	Interleukin-6, obstructive sleep apnea, and obesity. (14555603)	Inoue K.... Yoshikawa T.	2003	IL6
39	Soluble leptin receptor and insulin resistance as determinant of sleep apnea. (11896492)	Manzella D.... Paolisso G.	2002	LEPR
40	'Warning card' as a prevention of prolonged apnea in children. (12674844)	Lajtman Z.... Rudez J.	2002	BCHE
41	Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. (10720054)	Vgontzas A.N.... Chrousos G.P.	2000	LEP
42	Effects of obstructive sleep apnea on endothelin-1 and blood pressure. (10100095)	Phillips B.G.... Somers V.K.	1999	EDN1
43	No relation between apolipoprotein E alleles and obstructive sleep apnea. (9611077)	Saarelainen S.... Nieminen M.M.	1998	APOE
44	Respiratory effort. A factor contributing to sleep pr opensity in patients with obstructive sleep apnea. (8617072)	Zamagni M.... Krieger J.	1996	GTF3A
45	An unusual reason for obstructive sleep apnea in a boy with hemophilia B: supraglottic papilloma. (8770685)	JakubA-kovA! J.... BA!torovA! A.	1996	F9
46	Nocturnal hypertension and sleep apnea: effect of th e ACE inhibitor cilazapril on apnea-induced blood pressure increases during sle ep (7617607)	Grote L.... Wichert P.V.	1995	ACE
47	Effect of octreotide, a somatostatin analog, on sleep apnea in patients with acromegaly. (8067645)	Grunstein R.R.... Sullivan C.E.	1994	SST
48	Genetics and obstructive sleep apnea syndrome: a study of human leukocyte antigen (HLA) typing. (8507936)	Yoshizawa T.... Horie T.	1993	HLA-C
49	Diurnal and nocturnal diuresis and natriuresis in obs tructive sleep apnea. Effects of nasal continuous positive airway pressure ther apy. (1596005)	Rodenstein D.O.... Aubert-Tulkens G.	1992	REN
50	Sleep-related obstructive and nonobstructive apneas a nd neurologic disorders. (1630639)	Guilleminault C.... Quera-Salva M.A.	1992	MGAM

Genes related to apnea according to GeneCards:

(show top 50)    (show all 164)

id	Symbol	Description	Score	GeneCards Section Context
1	CHAT	choline O-acetyltransferase	11.1	Publications, Summaries
2	BCHE	butyrylcholinesterase	11.1	Publications, Summaries
3	CEPA	congenital episodic primary apnea	11.0	Aliases & Descriptions
4	NPPB	natriuretic peptide B	11.0	Publications
5	SLC6A5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	11.0	Summaries
6	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
7	LSL	Leptin, serum levels of	11.0	Publications
8	LEP	leptin	11.0	Publications
9	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
10	RETN	resistin	11.0	Publications
11	HSPA1A	heat shock 70kDa protein 1A	11.0	Publications
12	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
13	NPPA	natriuretic peptide A	11.0	Publications
14	ADRB2	adrenoceptor beta 2, surface	11.0	Publications
15	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
16	NPY	neuropeptide Y	11.0	Publications
17	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
18	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
19	KNG1	kininogen 1	11.0	Publications
20	HTR3E	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	11.0	Publications
21	HTR3D	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	11.0	Publications
22	NPS	neuropeptide S	11.0	Publications
23	KCNMB1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	11.0	Publications
24	HTR3C	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	11.0	Publications
25	PHOX2B	paired-like homeobox 2b	11.0	Publications
26	UCN3	urocortin 3 (stresscopin)	11.0	Publications
27	NDN	necdin homolog (mouse)	11.0	Publications
28	EIF4EBP2	eukaryotic translation initiation factor 4E binding protein 2	11.0	Publications
29	CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	11.0	Publications
30	PSPH	phosphoserine phosphatase	11.0	Publications
31	GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	11.0	Publications
32	INSIG2	insulin induced gene 2	11.0	Publications
33	MCAM	melanoma cell adhesion molecule	11.0	Publications
34	MC3R	melanocortin 3 receptor	11.0	Publications
35	ASCL1	achaete-scute complex homolog 1 (Drosophila)	11.0	Publications
36	ADRB1	adrenoceptor beta 1	11.0	Publications
37	GTF3A	general transcription factor IIIA	11.0	Publications
38	APLN	apelin	11.0	Publications
39	MSX1	msh homeobox 1	11.0	Publications
40	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	11.0	Publications
41	FABP4	fatty acid binding protein 4, adipocyte	11.0	Publications
42	SAA1	serum amyloid A1	11.0	Publications
43	HTR3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	11.0	Publications
44	MSX2	msh homeobox 2	11.0	Publications
45	CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	11.0	Publications
46	TCOF1	Treacher Collins-Franceschetti syndrome 1	11.0	Publications
47	NAMPT	nicotinamide phosphoribosyltransferase	11.0	Publications
48	MC4R	melanocortin 4 receptor	11.0	Publications
49	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.0	Publications
50	PMP22	peripheral myelin protein 22	11.0	Publications

Pathways related to apnea according to GeneDecks:

(show top 50)    (show all 94)

id	Pathway	Score	Top Affiliating Genes
1	Sympathetic Nerve Pathway (Neuroeffector Junction)34	10.8	ADRA2A, ADRA1B, ADM, NPY, TH, CHAT
2	Neuroactive ligand-receptor interaction20	10.6	GHR, HCRTR2, TSPO, AGTR1, EDNRA, NR3C1
3	Calcium signaling pathway20	10.4	CYSLTR1, NOS2, NOS3, HTR2C, EDNRA, AGTR1
4	G alpha (q) signalling events38	10.3	EDN1, EDN3, CCKAR, EDNRA, HCRT, HCRTR2
5	Intracellular Calcium Signaling36	10.3	IGF2, IL6, FGFR3, BDNF, HTR1B, FGFR1
6	ERK5 Signaling36	10.3	BDNF, TGFBR1, PDGFB, NTRK1, SPON1, GH1
7	Actin-Based Motility by Rho Family GTPases36	10.2	BDNF, FGFR3, IGF1, GNB3, GH1, GHRH
8	Telomerase Components in Cell Signaling36	10.2	IGF1, FGFR1, BDNF, GH1, PDGFB, FGFR2
9	Activation of PKA through GPCR36	10.1	BDNF, FGFR1, SPON1, GH1, GNB3, IGF1
10	Signaling Involved in Cardiac Hypertrophy36	10.1	GNB3, NTRK1, IRS1, FGFR1, FGFR2, ADRB1
11	Activation of cAMP-Dependent PKA36	10.1	FGFR3, IL6, ADRB3, ADRB2, PDGFB, NOS3
12	cAMP Pathway36	10.1	FGFR1, ADRB3, SPON1, ADRB1, BDNF, ADRB2
13	Statin Pathway, Pharmacodynamics34	10.0	LPL, APOB, APOE, FDFT1, APOA1, HMGCR
14	Apoptotic Pathways in Synovial Fibroblasts36	9.9	GH1, TGFBR1, NTRK1, BDNF, FGFR1, FGFR2
15	Selected targets of HNF110	9.9	UCP2, INS, APOA1, APOH, ALB, CRP
16	Akt Signaling36	9.9	PF4, IRS1, FGFR1, IL4, IL10, IL6
17	PPAR Pathway36	9.8	TNF, SPON1, IL6, NTRK1, IGF1, TGFBR1
18	Renin-Angiotensin Pathway36	9.8	IGF1, AGTR1, AGT, ACE, PDGFB, NTRK1
19	eIF2 Pathway36	9.8	PDGFB, BDNF, IGF1, IGF2, IL6, INS
20	Selected targets of GCR-alpha10	9.7	LEP, NR3C1, INS, IL8, IL6, IL4
21	Endothelin-1 Signaling Pathway36	9.7	FGFR2, EDNRA, ECE1, CXCL6, EDN1, PF4
22	Activation of PKC through GPCR36	9.7	TGFBR1, PDGFB, SPON1, GHRH, GH1, GNB3
23	Immune response IL-1 signaling pathway10	9.6	SERPINE1, IL8, NOS2, TNF, EDN1, HMOX1
24	Immune response_IL-1 signaling pathway41	9.6	CP, IL8, SERPINE1, NOS2, EDN1, TNF
25	ERK Signaling36	9.6	CXCL6, IL13, GHRH, PF4, IGF2, IL6
26	Cytokine Network36	9.4	IL8, IL6, IL4, IL1B, IL18, IL13
27	NF-KappaB (p50-p65) Pathway36	9.3	FGFR3, IGF2, IL1B, FGFR2, FGFR1, BDNF
28	p70S6K Signaling36	9.3	HBG1, PDGFB, GNB3, TGFBR1, IRS1, IL4
29	p53 Mediated Apoptosis36	9.2	FGFR2, TGFBR1, PDGFB, NTRK1, SPON1, GHRH
30	Mitochondrial Apoptosis36	9.2	SPON1, TGFBR1, PDGFB, NTRK1, GHRH, GH1
31	Cellular Apoptosis Pathway36	9.1	TGFBR1, IL6, FGFR2, BDNF, BAX, FGFR1
32	African trypanosomiasis20	9.1	IL10, IL1B, SELE, VCAM1, IL18, IL6
33	Molecular Mechanisms of Cancer36	9.1	SPON1, IGF2, GNB3, GH1, PF4, PDGFB
34	Pathways in cancer20	9.1	NOS2, FGFR2, RET, BAX, MMP9, FGFR1
35	Cytokine-cytokine receptor interaction20	9.1	LEP, IL13, CXCL6, PDGFB, PF4, TNF
36	DHA Signaling36	9.0	TGFBR1, PDGFB, BDNF, BAX, FGFR1, IGF2
37	JNK Pathway36	9.0	SPON1, BAX, NTRK1, IRS1, PDGFB, GHRH
38	Malaria20	8.8	HBB, IL6, IL8, CCL2, ICAM1, TNF
39	MIF Mediated Glucocorticoid Regulation36	8.6	NR3C1, IL4, IL6, IL8, CCL2, TNF
40	MIF Regulation of Innate Immune Cells36	8.5	IL10, BAX, IL18, IL1B, IL4, IL6
41	PEDF Induced Signaling36	8.5	IL4, IL1B, BAX, BDNF, IL13, TNF
42	all-trans-Retinoic Acid Signaling in Brain36	8.4	IL13, IL18, IL1B, IL4, IL8, IL6
43	Rho Family GTPases36	8.1	FGFR3, CXCL6, PDGFB, PF4, NTRK1, SPON1
44	TGF-Beta Pathway36	8.1	PDGFB, TGFBR1, IL6, GHRH, GH1, IGF1
45	PAK Pathway36	8.0	IL6, IL4, IL1B, IL18, IL10, FGFR3
46	p38 Signaling36	8.0	BDNF, BAX, FGFR1, IL18, FGFR2, FGFR3
47	Antioxidant Action of Vitamin-C36	8.0	PDGFB, TGFBR1, CXCL6, NTRK1, CCL2, IGF2
48	MAPK Family Pathway36	8.0	SPON1, PDGFB, IL8, IL18, IL1B, IL4
49	Tec Kinases Signaling36	7.9	IL18, IL4, IL6, CCL2, IGF2, IGF1
50	JAK-STAT Pathway36	7.7	AGT, IL1B, IL18, IL13, IL10, FGFR3

Compounds related to apnea according to GeneDecks:

(show top 50)    (show all 550)

id	Compound	Score	Top Affiliating Genes
1	bromocriptine32 9 9	12.7	HTR2A, HTR2C, GH1, GHRH, SST, ADRA1B
2	phenylephrine32 9 18 9	13.4	LPL, LEP, APOB, EDN3, EDNRA, HCRT
3	ng-nitro-l-arginine32	10.4	BDNF, CALCA, NOS2, NOS3, EDN1, AGT
4	ang ii32	10.3	REN, CCL2, PPARG, NOS2, NOS3, EDN1
5	endotoxin32	10.3	RETN, LEPR, SAA1, IL18, APOH, F9
6	p00332	10.3	RETN, SERPINE1, LEP, UCP2, UCP3, S100B
7	hyaluronic acid32 18	11.3	IL13, GPT, SLC17A5, GGT1
8	catecholamine32	10.2	REN, RET, BDNF, CHAT, UCP2, S100B
9	perindopril32 34 9 9	13.2	REN, VWF, SERPINE1, BCHE, ALB, CRP
10	glycerol32 9 18 9	13.1	VWF, PCNA, LPL, LEP, CD79A, IRS1
11	intralipid32	10.1	LPL, LEP, UCP3, APOA1, APOB, APOE
12	salbutamol32 34 9 18 9	14.1	VCAM1, UCP3, CD79A, IL10, IL13, IL18
13	cyclic amp32 18	11.0	RET, BDNF, CHKA, FMR1, IL18, MC3R
14	5-hydroxytryptamine32	10.0	SERPINE1, CHAT, ENO2, HTR1B, HTR2A, HTR2C
15	enalapril32 9 9	12.0	REN, SERPINE1, IL10, APOA1, ALB, EDN1
16	carbohydrates32	10.0	SELE, SELP, VCAM1, BCHE, UCP2, MGAM
17	n(g)-nitro-l-arginine methyl ester32	10.0	SERPINE1, BDNF, LEP, CALCA, NOS2, NOS3
18	prostaglandin f2alpha32	10.0	SERPINE1, LPL, GPD1, IGFBP3, IGF1, CALCA
19	valsartan32 42 9 9	12.9	REN, SELP, SERPINE1, CCL2, ALB, PPARG
20	homocysteine32 18	10.8	RETN, VWF, SELE, SELP, SERPINE1, VCAM1
21	fenfluramine32 9 9	11.7	LEP, IGF2, IGFBP3, HTR1B, HTR2A, HTR2C
22	metformin32 34 9 9	12.7	RETN, VWF, SERPINE1, NAMPT, LPL, LEP
23	dihydrotestosterone32 9 18 9	12.6	SERPINE1, LPL, LEP, CHKA, CD79A, IL4
24	verapamil32 34 9 18 9	13.6	REN, APOB, GPT, GH1, CYP2D6, PF4
25	carnitine32	9.6	LPL, CHKA, CHAT, UCP2, UCP3, CD79A
26	warfarin32 34 9 18 9	13.5	VWF, SELP, CD79A, APOB, APOE, APOH
27	cocaine32 9 9	11.5	SELE, SELP, VCAM1, BDNF, BCHE, LEP
28	amlodipine32 9 18 9	12.5	REN, SERPINE1, VCAM1, ALB, HMGCR, CYP2D6
29	forskolin32 42 9 9	12.4	REN, RETN, BDNF, CHAT, S100B, FMR1
30	estradiol32 9 18 9	12.3	REN, PCNA, SERPINE1, BDNF, LEPR, CHKA
31	vitamin b1232	9.2	VWF, PCNA, CD79A, CD40LG, APOA1, APOB
32	uric acid32 18	10.2	RETN, RBP4, SERPINE1, LEP, CHKA, INS
33	olanzapine32 34 9 18 9	13.1	BDNF, LEP, LEPR, CHAT, INS, APOE
34	nifedipine32 9 9	10.9	REN, SELE, SERPINE1, BDNF, LEP, CHAT
35	alpha tocopherol32	8.7	RBP4, LPL, VCAM1, LEP, CHKA, MMP9
36	cyclosporin a32 42	9.6	VWF, SELP, LPL, LEP, S100B, MMP9
37	vitamin d32	8.5	SERPINE1, LPL, LEPR, CHKA, CD79A, FGFR2
38	heparin32 9 18 9	11.4	VWF, SERPINE1, LPL, BCHE, UCP3, CD79A
39	atorvastatin32 34 9 18 9	12.2	RETN, VWF, SELE, SELP, SERPINE1, LPL
40	troglitazone32 42 9 9	11.1	SELE, SERPINE1, LPL, VCAM1, LEP, UCP2
41	butyrate32	8.0	RET, PCNA, BCHE, LEP, CHAT, BAX
42	histamine32 18	8.8	VWF, PCNA, SELE, SELP, VCAM1, BDNF
43	methotrexate32 34 42 9 9	11.6	PCNA, SELE, SERPINE1, LEP, CD79A, MMP9
44	genistein32 9 18 9	10.1	RET, PCNA, SELE, SELP, SERPINE1, LPL
45	glutamine32	7.0	VWF, PCNA, LPL, LEPR, UCP2, S100B
46	paraffin32	7.0	RET, VWF, PCNA, VCAM1, LEP, CHKA
47	estrogen32	6.9	RETN, VWF, PCNA, RBP4, SERPINE1, LPL
48	nitric oxide32 9 18 9	9.8	REN, RETN, SELE, SELP, VCAM1, CHAT
49	lipid32	6.8	RET, RETN, RBP4, SELE, SERPINE1, NAMPT
50	dexamethasone32 42 34 9 9	9.3	REN, RETN, VWF, PCNA, RBP4, SELP

Cellular components related to apnea according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.9	PDGFB, PF4, ALB, IGF1, SERPINE1, VWF
2	neuronal cell body	GO:043025	9.6	GHR, SST, TAC1, SOD1, GABBR1, CALCA
3	external side of plasma membrane	GO:009897	9.5	ECE1, ACE, TNF, ICAM1, MCAM, IL4
4	integral to plasma membrane	GO:005887	9.0	OPRM1, TACR1, AGTR1, HCRTR2, EDNRA, NTRK1
5	plasma membrane	GO:005886	7.4	SHH, EDNRA, ACE, HCRTR2, AGTR1, TGFBR1
6	extracellular region	GO:005576	7.0	GDNF, GABBR1, RETN, IL1B, IL6, IL8
7	extracellular space	GO:005615	6.3	IL1B, IL4, IL6, IL8, APOA1, APOB

Biological processes related to apnea according to GeneDecks:

(show top 50)    (show all 70)

id	Name	GO ID	Score	Top Affiliating Genes
1	synaptic transmission	GO:007268	11.0	HCRT, HCRTR2, TAC1, PMP22, NPY, SLC6A5
2	response to cold	GO:009409	10.7	ADRB1, ADRB3, ADM, ADRB2, AGT, PPARG
3	sensory perception of pain	GO:019233	10.7	ADRB1, TAC1, TACR1, EDNRA, EDN1, HTR2A
4	phospholipase C-activating G-protein coupled receptor signaling pathway	GO:007200	10.7	TACR1, MC3R, CCKAR, HCRT, HCRTR2, AGT
5	response to insulin stimulus	GO:032868	10.7	FABP3, NR3C1, PDGFB, NPPA, ADM, MC4R
6	regulation of vasoconstriction	GO:019229	10.6	ECE1, AGTR1, AGT, ACE, EDN3, EDN1
7	positive regulation of MAP kinase activity	GO:043406	10.6	ADRA2A, EDN3, EDN1, PDGFB, TNF, GH1
8	negative regulation of blood coagulation	GO:030195	10.6	SERPINE1, APOE, APOH, EDN1, PROC, KNG1
9	feeding behavior	GO:007631	10.6	MC4R, CCKAR, HTR2C, CALCA, HCRTR2, NPY
10	diet induced thermogenesis	GO:002024	10.6	MC4R, ADRB2, ADRB3, ADRB1
11	positive regulation of renal sodium excretion	GO:035815	10.5	KNG1, NPPB, OXT, TAC1, TACR1, AGT
12	positive regulation of vasodilation	GO:045909	10.5	ADM, ADRB2, NOS3, HMOX1, CALCA, INS
13	leukocyte tethering or rolling	GO:050901	10.4	TNF, LEP, VCAM1, SELP, SELE
14	negative regulation of smooth muscle cell proliferation	GO:048662	10.3	ADIPOQ, NPPB, NOS3, PPARG, HMOX1, IGFBP3
15	aging	GO:007568	10.2	ADM, ADRB3, ADRB1, EPO, TSPO, AGT
16	response to nutrient	GO:007584	10.2	ADIPOQ, PPARG, SST, HMGCR, CCKAR, IL4
17	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.2	AGT, PDGFB, GH1, IGF1, FGFR1, INS
18	response to nicotine	GO:035094	10.2	GABBR1, TACR1, EDN1, HMOX1, IL13, MMP9
19	positive regulation of MAPK cascade	GO:043410	10.2	LEP, INS, FGFR1, FGFR2, FGFR3, IL6
20	glucose homeostasis	GO:042593	10.2	ADIPOQ, ADRA2A, ADRA1B, HIF1A, PPARG, INS
21	response to ethanol	GO:045471	10.1	CCL2, ICAM1, HTR1B, NOS3, SHH, TH
22	memory	GO:007613	10.1	ADRB1, SLC6A4, OXT, TH, HTR2A, IL1B
23	response to lipopolysaccharide	GO:032496	10.1	EPO, ADM, TAC1, EDNRA, EDN1, CCKAR
24	response to morphine	GO:043278	10.1	ADRA1B, TAC1, TACR1, EDNRA, GHR, IL1B
25	regulation of blood pressure	GO:008217	10.1	HMOX1, CALCA, GNB3, LEP, REN, PPARG
26	positive regulation of cell proliferation	GO:008284	10.1	PDGFB, SHH, EDN1, EDN3, EDNRA, TGFBR1
27	positive regulation of smooth muscle cell proliferation	GO:048661	10.0	HIF1A, EDN1, PDGFB, TNF, HMOX1, IGF1
28	elevation of cytosolic calcium ion concentration	GO:007204	10.0	ADM, KNG1, SAA1, IL1B, CCKAR, CALCA
29	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.0	IGF1, GH1, GHR, PDGFB, AGT, ADIPOQ
30	platelet degranulation	GO:002576	10.0	KNG1, SOD1, TF, PDGFB, PF4, ALB
31	leukocyte cell-cell adhesion	GO:007159	10.0	CALCA, ICAM1, CD40LG, VCAM1, SELP, SELE
32	response to heat	GO:009408	10.0	SOD1, TACR1, NOS3, SST, CALCA, CCKAR
33	positive regulation of mitosis	GO:045840	9.9	EDN3, EDN1, PDGFB, TNF, IGF1, IGF2
34	negative regulation of cell proliferation	GO:008285	9.9	TNF, SST, NTRK1, NOS3, AGT, PMP22
35	negative regulation of apoptotic process	GO:043066	9.9	ALB, TNF, PF4, SHH, EDNRA, PROC
36	platelet activation	GO:030168	9.9	PF4, PDGFB, TF, SOD1, KNG1, ADRA2A
37	heart development	GO:007507	9.8	TH, TGFBR1, OXT, NPPB, ECE1, ADM
38	response to hypoxia	GO:001666	9.8	ADIPOQ, ADM, NOS3, PDGFB, SHH, EDN1
39	G-protein coupled receptor signaling pathway	GO:007186	9.8	EDN1, EDNRA, AGT, AGTR1, ADRA1B, ADRA2A
40	cell-cell signaling	GO:007267	9.7	SHH, EDN1, EDN3, AGT, TAC1, CXCL6
41	MAPK cascade	GO:000165	9.6	TNF, CCL2, IL1B, IL18, FGFR3, FGFR1
42	response to glucocorticoid stimulus	GO:051384	9.4	GHR, TNF, OXT, ADM, ADIPOQ, CCKAR
43	inflammatory response	GO:006954	9.3	TNF, CYSLTR1, CYBA, CRP, TACR1, TAC1
44	positive regulation of apoptotic process	GO:043065	9.3	AGT, TSPO, SOD1, KNG1, ADRB2, NOS3
45	response to estradiol stimulus	GO:032355	9.3	SLC6A4, OXT, SHH, PDGFB, NOS3, GHR
46	response to drug	GO:042493	9.2	REN, HTR2A, HTR2C, TNF, SST, PPARG
47	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	HBB, EDN1, TNF, ICAM1, IL1B, INS
48	blood coagulation	GO:007596	9.1	PDGFB, SHH, HBB, HBG1, TF, PROC
49	anti-apoptosis	GO:006916	9.0	NR3C1, NOS3, PRNP, SOD1, EPO, GDNF
50	small molecule metabolic process	GO:044281	7.9	CYP7A1, HMGCR, HMOX1, GNB3, ALB, GPD1

Molecular functions related to apnea according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	norepinephrine binding	GO:051380	10.6	ADRA2A, ADRB1, ADRB3, ADRB2
2	serotonin receptor activity	GO:004993	10.6	HTR3B, HTR3A, HTR2C, HTR2A, HTR1B
3	choline binding	GO:033265	10.5	CRP, CHAT, CHKA, BCHE
4	epinephrine binding	GO:051379	10.2	ADRB1, ADRB3, ADRB2, ADRA2A
5	receptor binding	GO:005102	10.2	NPPB, NPY, KNG1, ADM, ADIPOQ, GDNF
6	heparin binding	GO:008201	10.2	CCL2, PF4, CXCL6, KNG1, APOH, APOE
7	hormone activity	GO:005179	10.2	EPO, APLN, INS, UCN3, LEP, RETN
8	insulin-like growth factor receptor binding	GO:005159	9.8	IGF1, IGF2, INS, IRS1, REN
9	drug binding	GO:008144	9.7	ADRB1, ADRB2, ACE, PPARG, CYP2D6, ALB
10	growth factor activity	GO:008083	9.4	GDNF, AGT, PDGFB, GH1, IGF1, IGF2
11	cytokine activity	GO:005125	9.4	ADIPOQ, EDN1, TNF, IL6, IL4, IL1B
12	protein homodimerization activity	GO:042803	8.3	GDNF, ADIPOQ, ADRA2A, ADRB3, ADRB2, VWF
13	protein binding	GO:005515	4.0	CRP, NOS2, NOS3, PDGFB, SHH, EIF4EBP2