MCID: APN008
MIFTS: 67

Apnea, Obstructive Sleep

Categories: Neuronal diseases, Mental diseases

Aliases & Classifications for Apnea, Obstructive Sleep

MalaCards integrated aliases for Apnea, Obstructive Sleep:

Name: Apnea, Obstructive Sleep 53
Obstructive Sleep Apnea 12 72 28 14 59
Obstructive Sleep Apnea Syndrome 53 12
Sleep Apnea Syndromes 41 69
Sleep Apnea/hypopnea Syndrome; Sahs; Osahs 53
Obstructive Sleep Apnea Syndrome; Osas 53
Sleep Apnea/hypopnea Syndrome 53
Sleep Apnea, Obstructive 69
Sleep Apnea Obstructive 51
Osas 53
Sahs 53
Osa 53

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant


HPO:

31
apnea, obstructive sleep:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Apnea, Obstructive Sleep

PubMed Health : 59
About obstructive sleep apnea: We all know what it is like to feel tired after a sleepless night because of things like noise, worries or stress. But what if you do actually get enough sleep and still feel absolutely beat the next morning? This is normal for many people with obstructive sleep apnea (OSA): They do not get enough air while they are sleeping (but do not usually notice this), have breathing pauses, and feel very sleepy during the day. In the long term, this increases their risk of developing other illnesses and can have a huge effect on their quality of life.

MalaCards based summary : Apnea, Obstructive Sleep, also known as obstructive sleep apnea, is related to kawasaki disease and body mass index quantitative trait locus 11, and has symptoms including snoring, excessive daytime somnolence and anosmia. An important gene associated with Apnea, Obstructive Sleep is AHDC1 (AT-Hook DNA Binding Motif Containing 1), and among its related pathways/superpathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Selenium Micronutrient Network. The drugs Guanfacine and Hydrochlorothiazide have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and endothelial, and related phenotypes are cardiovascular system and behavior/neurological

OMIM : 53 Obstructive sleep apnea is a common, chronic, complex disease associated with serious cardiovascular and neuropsychologic sequelae and with substantial social and economic costs (Palmer et al., 2003). (107650)

Disease Ontology : 12 A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.

Wikipedia : 72 Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by complete or... more...

Related Diseases for Apnea, Obstructive Sleep

Diseases related to Apnea, Obstructive Sleep via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 kawasaki disease 31.7 CRP IL6 TNF
2 body mass index quantitative trait locus 11 29.1 ADIPOQ CRP HCRT IL6 INS LEP
3 hypertension, essential 29.0 ADIPOQ CRP EDN1 INS LEP REN
4 sleep apnea 28.6 ADIPOQ AHDC1 CRP EDN1 HCRT HTR2A
5 autoimmune encephalopathy with parasomnia and obstructive sleep apnea 12.3
6 3mc syndrome 2 11.4
7 acquired generalized lipodystrophy 10.6 ADIPOQ LEP
8 idiopathic recurrent pericarditis 10.5 ADIPOQ LEP
9 malignant otitis externa 10.5 CRP INS
10 cold agglutinin disease 10.5 CRP IL6
11 scorpion envenomation 10.4 IL6 TNF
12 obesity-hypoventilation syndrome 10.4 ADIPOQ IL6 LEP
13 multiple symmetrical lipomatosis 10.4 ADIPOQ IL6 LEP
14 diabetic foot ulcers 10.4 CRP IL6
15 abdominal obesity-metabolic syndrome 1 10.4 ADIPOQ INS LEP
16 cryopyrin-associated periodic syndrome 10.4 CRP IL6
17 endocrine pancreas disease 10.4 ADIPOQ INS LEP
18 bulimia nervosa 2 10.4 ADIPOQ HTR2A LEP
19 acanthosis nigricans 10.4 ADIPOQ INS LEP
20 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.4 CRP INS LEP
21 neutrophilia, hereditary 10.4 CRP IL6
22 nontuberculous mycobacterial lung disease 10.4 ADIPOQ LEP TNF
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
24 nutritional deficiency disease 10.3 CRP IL6 LEP
25 acute cholangitis 10.3 CRP IL6
26 intermittent claudication 10.3 CRP HTR2A IL6
27 critical limb ischemia 10.3 IL6 TNF
28 coronary heart disease 1 10.3 ADIPOQ CRP INS
29 acute adrenal insufficiency 10.3 IL6 REN
30 protein-energy malnutrition 10.3 IL6 LEP TNF
31 uremia 10.3 CRP INS LEP
32 gestational diabetes 10.3 ADIPOQ INS LEP
33 hypertensive retinopathy 10.3 ADIPOQ REN
34 central nervous system vasculitis 10.3 CRP IL6 TNF
35 louse-borne relapsing fever 10.3 CRP IL6 TNF
36 ischemic heart disease 10.3 CRP IL6 TNF
37 adult-onset still's disease 10.3 CRP IL6 TNF
38 perinatal necrotizing enterocolitis 10.3 CRP IL6 TNF
39 lymph node disease 10.3 CRP IL6 TNF
40 infective endocarditis 10.3 CRP IL6 TNF
41 hemorrhagic fever with renal syndrome 10.3 CRP IL6 TNF
42 early-onset schizophrenia 10.3 HTR2A INS TNF
43 uterine anomalies 10.3 CRP IL6 TNF
44 leptospirosis 10.2 CRP IL6 TNF
45 pericarditis 10.2 CRP IL6 TNF
46 reactive arthritis 10.2 CRP IL6 TNF
47 pulmonary disease, chronic obstructive 10.2 CRP IL6 TNF
48 brucellosis 10.2 CRP IL6 TNF
49 pyelonephritis 10.2 CRP IL6 TNF
50 typhoid fever 10.2 CRP IL6 TNF

Graphical network of the top 20 diseases related to Apnea, Obstructive Sleep:



Diseases related to Apnea, Obstructive Sleep

Symptoms & Phenotypes for Apnea, Obstructive Sleep

Symptoms via clinical synopsis from OMIM:

53
Resp:
snoring
obstructive sleep apnea

Misc:
hypersomnolence
restless movements during sleep

Neuro:
anosmia
partial complex seizures


Clinical features from OMIM:

107650

Human phenotypes related to Apnea, Obstructive Sleep:

31
# Description HPO Frequency HPO Source Accession
1 snoring 31 HP:0025267
2 excessive daytime somnolence 31 HP:0001262
3 anosmia 31 HP:0000458
4 obstructive sleep apnea 31 HP:0002870
5 focal seizures with impairment of consciousness or awareness 31 HP:0002384

UMLS symptoms related to Apnea, Obstructive Sleep:


disruption of 24 hour sleep wake cycle, unspecified, hypersomnia with sleep apnea, unspecified, insomnia with sleep apnea, unspecified, sleeplessness, excessive daytime somnolence, labored breathing, vertigo/dizziness, chronic pain, wheezing, tremor, syncope, snoring, sleep disturbances, seizures, sciatica, pain, headache, dyspnea, coughing, cheyne-stokes respiration, back pain, apnea

MGI Mouse Phenotypes related to Apnea, Obstructive Sleep:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ADIPOQ HCRT IL6 CENPJ INS CRP
2 behavior/neurological MP:0005386 10.1 HCRT ADIPOQ HTR2A AHI1 IL6 CENPJ
3 growth/size/body region MP:0005378 10.06 EDN1 HCRT ADIPOQ AHI1 IL6 CENPJ
4 homeostasis/metabolism MP:0005376 10.03 EDN1 HCRT ADIPOQ AHI1 IL6 CENPJ
5 adipose tissue MP:0005375 9.91 ADIPOQ IL6 CENPJ INS LEP TNF
6 immune system MP:0005387 9.9 LEP ADIPOQ AHI1 IL6 CENPJ INS
7 muscle MP:0005369 9.7 ADIPOQ HCRT HTR2A IL6 CENPJ INS
8 renal/urinary system MP:0005367 9.23 LEP EDN1 ADIPOQ AHI1 IL6 INS

Drugs & Therapeutics for Apnea, Obstructive Sleep

PubMedHealth treatment related to Apnea, Obstructive Sleep: 59

If you are very overweight, losing weight can help improve sleep apnea. There are also many treatment options that aim to relieve sleep apnea. These include machines that support breathing during the night, surgery, and special aids such as mouth guards. Some of these treatments have been scientifically proven to help people with sleep apnea. Medication is currently not used for the treatment of sleep apnea. There is no scientific evidence that the available medications work.The most effective treatment for severe sleep apnea is called CPAP therapy. CPAP stands for “continuous positive airway pressure.” In this treatment approach, air is taken from the immediate surroundings and blown into your airways at night using low pressure. While you sleep, you wear a breathing mask that is connected to a machine called a respirator. The pressure keeps the upper airways open. People who use this machine have fewer breathing pauses, or even none at all. This can noticeably improve the symptoms such as tiredness during the day. Common side effects include a dry throat and an irritated, sometimes blocked nose.

Drugs for Apnea, Obstructive Sleep (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 406)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
3
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
4
Donepezil Approved Phase 4 120014-06-4 3152
5
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
6
Angiotensin II Approved, Investigational Phase 4,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
7
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
8
Budesonide Approved Phase 4,Phase 3,Phase 1 51333-22-3 5281004 63006
9
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
10
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
11
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2 2078-54-8 4943
12
Nitric Oxide Approved Phase 4 10102-43-9 145068
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1 57-27-2 5288826
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 437-38-7 3345
15
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
16
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
17
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
18
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
19
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
20
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112111-43-0
21
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 68693-11-8 4236
22
Sodium oxybate Approved Phase 4 502-85-2 5360545
23
Zolpidem Approved Phase 4 82626-48-0 5732
24
Acetazolamide Approved, Vet_approved Phase 4,Phase 2 59-66-5 1986
25
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
26
Adalimumab Approved Phase 4 331731-18-1 16219006
27
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
28
Ephedrine Approved Phase 4 299-42-3 9294
29
Pseudoephedrine Approved Phase 4 90-82-4 7028
30
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
31
Norepinephrine Approved Phase 4 51-41-2 439260
32
Eplerenone Approved Phase 4 107724-20-9 443872 150310
33
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
34
Eszopiclone Approved, Investigational Phase 4,Phase 2,Early Phase 1 138729-47-2 969472
35
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
36
Remifentanil Approved Phase 4,Early Phase 1 132875-61-7 60815
37
Losartan Approved Phase 4,Phase 2 114798-26-4 3961
38
Pantoprazole Approved Phase 4 102625-70-7 4679
39
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
40
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3 6740-88-1 3821
41
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
42
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
43
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
44
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 51-45-6, 75614-87-8 774
45
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 2 1491-59-4 4636
46
Phenylephrine Approved Phase 4,Phase 3,Phase 2 59-42-7 6041
47
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
48
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
49
Testosterone Approved, Investigational Phase 4 58-22-0 6013
50
Carbidopa Approved Phase 4 28860-95-9 38101 34359

Interventional clinical trials:

(show top 50) (show all 1325)

# Name Status NCT ID Phase Drugs
1 Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01590420 Phase 4
2 Validation of Functional Imaging as Predictive Tool for Outcome of Mandibular Replacement Appliance Therapy in Obstructive Sleep Apnea Hypopnea Syndrome Patients Unknown status NCT01524510 Phase 4
3 PROMAD: Predicting Therapeutic Outcome of Mandibular Advancement Device Treatment in Obstructive Sleep Apnea Unknown status NCT01532050 Phase 4
4 A Randomized Cross Over Trial of Two Treatments for Obstructive Sleep Apnea in Veterans With Post Traumatic Stress Disorder Unknown status NCT01535586 Phase 4
5 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Unknown status NCT02699125 Phase 4 Guanfacine;Hydrochlorothiazide
6 Comparison of the Pentax AWS® With the Macintosh Laryngoscopic Intubation in Obstructive Sleep Apnea Syndrome Patients Unknown status NCT01428570 Phase 4
7 CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients. Unknown status NCT01771406 Phase 4 Nebivolol
8 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
9 Donepezil Treatment for Sleep Apnea Patients Unknown status NCT00912457 Phase 4 donepezil;placebo
10 Intermittent Hypoxia 2: Cardiovascular and Metabolism Unknown status NCT02058823 Phase 4 Placebo;Placebo;Valsartan;Amlodipine
11 Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage Unknown status NCT00517777 Phase 4
12 Nasal Continuous Positive Airway Pressure (CPAP) in Chronic Fatigue and Sleep-disordered Breathing Unknown status NCT01368718 Phase 4
13 Multidisciplinary and Coordinated Follow-up Based on a Telemonitoring Web Platform for Improving CPAP Compliance in Low Cardiovascular Risk Sleep Apnea Patients : OPTISAS 1 Study Unknown status NCT01796769 Phase 4
14 Blood Pressure Reduction Induced by CPAP in Sleep Apnea Patients at High Cardiovascular Risk : OPTISAS 2 Study Unknown status NCT01505959 Phase 4
15 Obstructive Sleep Apnea in the Absence of Metabolic Syndrome Completed NCT01635010 Phase 4
16 Sugammadex Compared With Neostigmin/Atropin for Neuromuscular Block Reversal in Patients With Obstructive Sleep Apnea Completed NCT02160223 Phase 4 Sugammadex;Neostigmine
17 Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed NCT00086281 Phase 4 Xyrem (X);Zolpidem (Z);Modafinil (M);Placebo (P)
18 Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea Completed NCT00307957 Phase 4
19 Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients Completed NCT00741520 Phase 4
20 Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children Completed NCT00912171 Phase 4 budesonide (Aircort 50 nasal spray);montelukast (Singulair)
21 The Impact of Arousal Threshold in Obstructive Sleep Apnea Completed NCT02264353 Phase 4 Donepezil;placebo
22 Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude Completed NCT00714740 Phase 4 acetazolamide
23 Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome Completed NCT00560586 Phase 4 Budesonide;placebo
24 Early Signs of Atherosclerosis in Obstructive Sleep Apnea: Effects of Treatment Completed NCT00400543 Phase 4
25 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed NCT00518986 Phase 4 armodafinil;placebo
26 Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome Completed NCT00603044 Phase 4 fluticasone furoate
27 Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome Completed NCT01508754 Phase 4
28 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea Before and After Treatment With CPAP. Completed NCT00360659 Phase 4
29 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4 Paroxetine;5HTP
30 Sibutramine Versus Continuous Positive Airway Pressure (CPAP)in Obstructive Sleep Apnea (OSA) Patients Completed NCT00729963 Phase 4 Sibutramine
31 Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea Completed NCT01181570 Phase 4 Adalimumab;Placebo
32 Nasal Decongestion and Obstructive Sleep Apnea Completed NCT00630474 Phase 4 xylometazoline
33 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea and Healthy Controls. Completed NCT00291993 Phase 4
34 Effects of Continuous Positive Airway Pressure and Valsartan Treatments on Arterial Blood Pressure in OSAS Patients Completed NCT00409487 Phase 4 Valsartant treatment
35 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4 Dexmedetomidine;Propofol
36 Effects of Obstructive Sleep Apnea Treatment by Fixed CPAP and by Auto-CPAP (Somnosmart2) Completed NCT00633711 Phase 4
37 Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude Completed NCT00928655 Phase 4 acetazolamide;placebo
38 Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias Completed NCT00765713 Phase 4
39 The Endothelium Dysfunction in Patients of Obstructive Sleep Apnea Syndrome Completed NCT01699126 Phase 4 Statin
40 Renal Hemodynamics and Tubular Function in Patients With Obstructive Sleep Apnea and Healthy Controls Completed NCT00410085 Phase 4 L-NMMA (N-mono.methyl-L-arginine)
41 Reduction of Left Ventricular Hypertrophy After Eplerenone Therapy Completed NCT03186742 Phase 4 Eplerenone 50 mg Tab
42 Continuous Positive Airway Pressure (CPAP) Promotion And Prognosis - the Army Sleep Apnea Program (ASAP) Completed NCT00612157 Phase 4 Eszopiclone;Placebo control
43 Inspire® Upper Airway Stimulation (UAS) System German Post-Market Study Completed NCT02293746 Phase 4
44 Oxidative Stress and Cardiovascular Morbidity in Sleep Apnea-Hypopnea Syndrome (SAHS) Completed NCT00487929 Phase 4
45 Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea Completed NCT01945801 Phase 4 Lasilactone;Placebo
46 Auto Bilevel Adherence Following a Poor Initial Encounter With Continuous Positive Airway Pressure (CPAP) Completed NCT02522442 Phase 4
47 A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial Completed NCT01895348 Phase 4 Propofol;propofol-remifentanil;Dexmedetomidine-remifentanil
48 Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea Completed NCT00772044 Phase 4
49 Ezopiclone Improves the Quality of Overnight Polysomnography Completed NCT00507117 Phase 4 Lunesta;Placebo control
50 CPAP in Diabetes Type 2 Patients With Sleep Apnea Completed NCT01801150 Phase 4

Search NIH Clinical Center for Apnea, Obstructive Sleep

Cochrane evidence based reviews: sleep apnea syndromes

Genetic Tests for Apnea, Obstructive Sleep

Genetic tests related to Apnea, Obstructive Sleep:

# Genetic test Affiliating Genes
1 Obstructive Sleep Apnea 28

Anatomical Context for Apnea, Obstructive Sleep

MalaCards organs/tissues related to Apnea, Obstructive Sleep:

38
Heart, Testes, Endothelial, Liver, Tongue, Brain, Kidney

Publications for Apnea, Obstructive Sleep

Articles related to Apnea, Obstructive Sleep:

(show top 50) (show all 1150)
# Title Authors Year
1
Alterations of IGF-1, complement C3 and superoxide dismutase in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome. ( 29441807 )
2018
2
The effect of positive and negative message framing on short term continuous positive airway pressure compliance in patients with obstructive sleep apnea. ( 29445540 )
2018
3
Obstructive Sleep Apnea Screening AmongA Surgical Patients: A Quality Improvement Project. ( 29429821 )
2018
4
Association of Adenotonsillectomy With Blood Pressure Among Hypertensive and Nonhypertensive Children With Obstructive Sleep Apnea. ( 29450504 )
2018
5
Pre- and post-operative evaluation of the frequency of nocturnal enuresis and Modified Pediatric Epworth Scale in pediatric obstructive sleep apnea patients. ( 29447815 )
2018
6
Kinesthetic stimulation for obstructive sleep apnea syndrome: An "on-off" proof of concept trial. ( 29449609 )
2018
7
Knowledge Gaps in the Perioperative Management of Adults with Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome. An Official American Thoracic Society Workshop Report. ( 29388810 )
2018
8
Comorbid obstructive sleep apnea and increased risk for sickle cell disease morbidity. ( 29450676 )
2018
9
Risk of obstructive sleep apnea in open-angle glaucoma versus controls using the STOP-Bang questionnaire. ( 29426446 )
2018
10
Lithuanian dentists' knowledge, attitudes, and clinical practices regarding obstructive sleep apnea: A nationwide cross-sectional study. ( 29431599 )
2018
11
Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea. ( 29433520 )
2018
12
Correlations between pediatric obstructive sleep apnea and longitudinal growth. ( 29447889 )
2018
13
Determinants of sleepiness in obstructive sleep apnea. ( 29444292 )
2018
14
Mandibular positioning techniques to improve sleep quality in patients with obstructive sleep apnea: current perspectives. ( 29440942 )
2018
15
Correction to: Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly. ( 29442289 )
2018
16
Improvement of Neuropathy Symptoms With Treatment of Obstructive Sleep Apnea in a Patient With Charcot-Marie-Tooth Disease. ( 29246265 )
2018
17
IGF-1-based screening reveals a low prevalence of acromegaly in patients with obstructive sleep apnea. ( 29388045 )
2018
18
A Modified Definition for Obstructive Sleep Apnea in Home Sleep Apnea Testing after Stroke or Transient Ischemic Attack. ( 29428326 )
2018
19
Determinants of obstructive sleep apnea syndrome: Pro-inflammatory state and dysfunction of high-density lipoprotein. ( 28935145 )
2017
20
The Erlangen Questionnaire: a new 5-item screening tool for obstructive sleep apnea in a sleep clinic population - A prospective, double blinded study. ( 28925472 )
2017
21
Gray Matter Hypertrophy and Thickening with Obstructive Sleep Apnea in Middle-aged and Older Adults. ( 28060546 )
2017
22
Investigation of the link between fluid shift and airway collapsibility as a mechanism for obstructive sleep apnea in congestive heart failure. ( 28057850 )
2017
23
Magnetic resonance imaging of the upper airway in patients with quadriplegia and obstructive sleep apnea. ( 29082563 )
2017
24
Central sleep apnea during continuous positive airway pressure therapy in obstructive sleep apnea patients: from the compliance to adaptation, maladaptation and reflexes. ( 29268457 )
2017
25
Diastolic Blood Pressure Rises with the Exacerbation of Obstructive Sleep Apnea in Males. ( 28922573 )
2017
26
Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis? ( 28168435 )
2017
27
Endothelin contributes to the blood pressure rise triggered by hypoxia in severe obstructive sleep apnea. ( 27906839 )
2017
28
Caveolin-1 polymorphisms in patients with severe obstructive sleep apnea. ( 27321703 )
2017
29
REM sleep behavior disorder and obstructive sleep apnea: does one "evil" make the other less or more "evil"? ( 28754242 )
2017
30
Obstructive sleep apnea and rhonchopathy are associated with downregulation of trefoil factor family peptide 3 (TFF3)-Implications of changes in oral mucus composition. ( 29028798 )
2017
31
Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: a randomized, placebo-controlled trial on psychological distress. ( 28083705 )
2017
32
Risk of obstructive sleep apnea among patients with Cushing's syndrome: a nationwide longitudinal study. ( 28735920 )
2017
33
A comparison of two screening tools for paediatric obstructive sleep apnea. ( 28944605 )
2017
34
Surgical Treatment of Obstructive Sleep Apnea on Cardiovascular Outcomes: A Systematic Review. ( 28923761 )
2017
35
Subcranial and orthognathic surgery for obstructive sleep apnea in achondroplasia. ( 29108917 )
2017
36
Tracking Dynamic Tongue Motion in Ultrasound Images for Obstructive Sleep Apnea. ( 28942270 )
2017
37
Home Sleep Testing for Diagnosing Obstructive Sleep Apnea. ( 29431388 )
2017
38
Correlation between Calpain-10 single-nucleotide polymorphisms and obstructive sleep apnea/hypopnoea syndrome with ischemic stroke in a Chinese population: A population-based study. ( 28422847 )
2017
39
Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea. ( 28449901 )
2017
40
Combined Orthodontic and Surgical Treatment in a 8-Years-Old Patient Affected By Severe Obstructive Sleep Apnea: A Case-Report. ( 28937905 )
2017
41
Angiopoietin-2 and soluble Tie-2 receptor plasma levels in children with obstructive sleep apnea and obesity. ( 28474375 )
2017
42
Bone Age and Serum Osteocalcin Levels in Children With Obstructive Sleep Apnea Hypopnea Syndrome Before and After Adenotonsillectomy. ( 26938749 )
2017
43
Melatonin Effects in REM Sleep Behavior Disorder Associated with Obstructive Sleep Apnea Syndrome: A case series. ( 28545360 )
2017
44
Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes. ( 28931780 )
2017
45
Effect of jaw-opening exercise on prevention of temporomandibular disorders pain associated with oral appliance therapy in obstructive sleep apnea patients: A randomized, double-blind, placebo-controlled trial. ( 28063976 )
2017
46
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea. ( 28078488 )
2017
47
The Role of Dentists in the Diagnosis and Treatment of Obstructive Sleep Apnea: Consensus and Controversy. ( 28942761 )
2017
48
Cardiovascular Events in Moderately to Severely Obese Obstructive Sleep Apnea Patients on Positive Airway Pressure Therapy. ( 28081532 )
2017
49
Screening of Obstructive Sleep Apnea Syndrome by Electronic-Nose Analysis of Volatile Organic Compounds. ( 28931931 )
2017
50
C-reactive protein improves the ability to detect cardiometabolic risk in mild-to-moderate obstructive sleep apnea. ( 28947597 )
2017

Variations for Apnea, Obstructive Sleep

ClinVar genetic disease variations for Apnea, Obstructive Sleep:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 AHDC1 NM_001029882.3(AHDC1): c.2373_2374delTG (p.Cys791Trpfs) deletion Pathogenic rs587779766 GRCh37 Chromosome 1, 27876253: 27876254
2 AHDC1 NM_001029882.3(AHDC1): c.2898delC (p.Tyr967Thrfs) deletion Pathogenic rs587779767 GRCh37 Chromosome 1, 27875729: 27875729
3 AHDC1 NM_001029882.3(AHDC1): c.2547delC (p.Ser850Profs) deletion Pathogenic rs587779768 GRCh37 Chromosome 1, 27876080: 27876080

Expression for Apnea, Obstructive Sleep

Search GEO for disease gene expression data for Apnea, Obstructive Sleep.

Pathways for Apnea, Obstructive Sleep

Pathways related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 ADIPOQ IL6 INS LEP TNF
2
Show member pathways
12.04 CRP IL6 INS TNF
3
Show member pathways
11.75 IL6 INS TNF
4 11.73 EDN1 IL6 TNF
5 11.69 EDN1 IL6 INS
6 11.67 EDN1 IL6 TNF
7
Show member pathways
11.64 ADIPOQ INS TNF
8 11.54 ADIPOQ IL6 INS LEP
9 11.47 ADIPOQ IL6 INS LEP TNF
10 11.45 ADIPOQ LEP TNF
11 11.34 EDN1 IL6 TNF
12
Show member pathways
10.97 CRP EDN1 LEP
13 10.61 CRP IL6 TNF
14 10.27 ADIPOQ IL6 LEP TNF

GO Terms for Apnea, Obstructive Sleep

Cellular components related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ADIPOQ CRP EDN1 HCRT IL6 INS
2 extracellular space GO:0005615 9.23 ADIPOQ CRP EDN1 IL6 INS LEP

Biological processes related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA binding transcription factor activity GO:0051091 9.82 EDN1 IL6 TNF
2 glucose homeostasis GO:0042593 9.81 ADIPOQ INS LEP
3 defense response to Gram-positive bacterium GO:0050830 9.81 CRP IL6 TNF
4 positive regulation of MAPK cascade GO:0043410 9.8 IL6 INS LEP
5 regulation of blood pressure GO:0008217 9.72 EDN1 LEP REN
6 cellular response to drug GO:0035690 9.71 ADIPOQ EDN1 REN
7 response to glucocorticoid GO:0051384 9.7 ADIPOQ IL6 TNF
8 positive regulation of MAP kinase activity GO:0043406 9.69 EDN1 HTR2A TNF
9 positive regulation of protein kinase activity GO:0045860 9.67 ADIPOQ MMD TNF
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.65 EDN1 IL6 TNF
11 leukocyte tethering or rolling GO:0050901 9.64 LEP TNF
12 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.62 ADIPOQ CRP
13 negative regulation of gluconeogenesis GO:0045721 9.62 ADIPOQ INS
14 positive regulation of insulin receptor signaling pathway GO:0046628 9.61 INS LEP
15 negative regulation of glucose import GO:0046325 9.61 LEP TNF
16 negative regulation of fat cell differentiation GO:0045599 9.61 ADIPOQ IL6 TNF
17 negative regulation of blood vessel diameter GO:0097756 9.59 CRP INS
18 negative regulation of potassium ion transport GO:0043267 9.58 HCRT HTR2A
19 artery smooth muscle contraction GO:0014824 9.58 EDN1 HTR2A
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 EDN1 INS TNF
21 negative regulation of hormone secretion GO:0046888 9.57 ADIPOQ EDN1
22 regulation of behavior GO:0050795 9.56 AHI1 HTR2A
23 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 ADIPOQ HTR2A IL6 INS
24 response to activity GO:0014823 9.54 ADIPOQ EDN1 LEP
25 acute-phase response GO:0006953 9.5 CRP IL6 INS
26 regulation of receptor activity GO:0010469 9.5 ADIPOQ EDN1 HCRT IL6 INS LEP
27 positive regulation of STAT protein import into nucleus GO:2000366 9.46 IL6 LEP
28 glucose metabolic process GO:0006006 9.46 ADIPOQ INS LEP TNF
29 negative regulation of lipid storage GO:0010888 8.92 CRP IL6 LEP TNF
30 positive regulation of cell proliferation GO:0008284 10 EDN1 HTR2A IL6 INS LEP

Molecular functions related to Apnea, Obstructive Sleep according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ADIPOQ AHI1 CENPJ CRP INS PPCDC
2 cytokine activity GO:0005125 9.46 ADIPOQ EDN1 IL6 TNF
3 insulin-like growth factor receptor binding GO:0005159 9.26 INS REN
4 hormone activity GO:0005179 8.92 ADIPOQ EDN1 INS LEP

Sources for Apnea, Obstructive Sleep

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....