MCID: APD001
MIFTS: 18

Apo a-I Deficiency malady

Summaries for Apo a-I Deficiency

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32MalaCards
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MalaCards: Apo a-I Deficiency is related to tangier disease and peripheral vascular disease. An important gene associated with Apo a-I Deficiency is APOA1 (apolipoprotein A-I), and among its related pathways are Selenium Pathway and "Ca, cAMP and Lipid Signaling". The compounds iohexol and fructosamine have been mentioned in the context of this disorder.

Aliases & Classifications for Apo a-I Deficiency

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42NIH Rare Diseases
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Aliases & Descriptions:

apo a-i deficiency 42


Related Diseases for Apo a-I Deficiency

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Apo a-I Deficiency:



Diseases related to apo a-i deficiency

Clinical Features for Apo a-I Deficiency

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Drugs & Therapeutics for Apo a-I Deficiency

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Apo a-I Deficiency

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Anatomical Context for Apo a-I Deficiency

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Animal Models for Apo a-I Deficiency or affiliated genes

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Publications for Apo a-I Deficiency

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Genetic Variations for Apo a-I Deficiency

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Expression for genes affiliated with Apo a-I Deficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Apo a-I Deficiency

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Pathways for genes affiliated with Apo a-I Deficiency

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37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Apo a-I Deficiency

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience
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Compounds related to Apo a-I Deficiency according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1iohexol449.5ALB, APOA1
2fructosamine44 2410.5ALB, APOA1
3hydrochlorothiazide44 49 28 11 2413.5APOA1, ALB
4enalapril44 49 1111.4ALB, APOA1
5rosuvastatin44 49 28 1112.4ALB, APOA1
625-hydroxyvitamin d449.4APOA1, ALB
7dextran sulfate449.4ALB, APOA1
8vitamin b12449.4ALB, APOA1
9uric acid44 2410.4APOA1, ALB
10polyethylene glycol449.4ALB, APOA1
11homocysteine44 2410.4APOA1, ALB
12thyroxine44 2410.3ALB, APOA1
13tacrolimus44 49 1111.3ALB, APOA1
14vitamin a44 11 2411.3APOA1, ALB
15ascorbic acid44 2410.2ALB, APOA1
16indomethacin44 59 28 1112.2APOA1, ALB
17fibrinogen449.1ALB, APOA1
18aspartate449.1ALB, APOA1
19lactate449.0ALB, APOA1
20creatinine448.8ALB, APOA1

GO Terms for genes affiliated with Apo a-I Deficiency

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16Gene Ontology
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Biological processes related to Apo a-I Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:0421579.2ALB, APOA1
2response to nutrientGO:0075849.1ALB, APOA1
3blood coagulationGO:0075969.1ALB, APOA1
4platelet degranulationGO:0025769.0APOA1, ALB
5platelet activationGO:0301688.8ALB, APOA1

Molecular functions related to Apo a-I Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1ALB, APOA1

Products for genes affiliated with Apo a-I Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Apo a-I Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet