MCID: APC004
MIFTS: 38

Apocrine Adenocarcinoma malady

Categories: Rare diseases, Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Apocrine Adenocarcinoma

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Aliases & Descriptions for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 10 12 65
Apocrine Carcinoma 10 45
Carcinoma of the Apocrine Gland 10
 
Carcinoma of Apocrine Gland 65
Apocrine Gland Carcinoma 10

Classifications:



External Ids:

Disease Ontology10 DOID:4933
SNOMED-CT59 57141000
UMLS65 C0334346, C1706827

Summaries for Apocrine Adenocarcinoma

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NIH Rare Diseases:45 Apocrine carcinoma is a cancer of a sweat gland.  apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  the cause of apocrine carcinoma is unknown.  apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  the average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  most apocrine carcinomas can be treated and are not fatal.  treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven. last updated: 6/16/2014

MalaCards based summary: Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to cystadenoma and vulvar apocrine adenocarcinoma. An important gene associated with Apocrine Adenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are Nuclear signaling by ERBB4 and FOXA1 transcription factor network. Affiliated tissues include breast, skin and ovary, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:10 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

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Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenoma30.3KRT5, PGR
2vulvar apocrine adenocarcinoma12.2
3breast apocrine carcinoma12.2
4breast apocrine carcinoma in situ12.0
5adenocarcinoma10.6
6adenofibroma10.5ERBB2, PGR
7her2-receptor positive breast cancer10.5ERBB2, PGR
8ovarian mesodermal adenosarcoma10.5ERBB2, PGR
9acute retinal necrosis syndrome10.5ERBB2, PGR
10papillary carcinoma10.4ERBB2, PGR
11synchronous bilateral breast carcinoma10.4ERBB2, PGR
12peritoneal cystic mesothelioma10.4ERBB2, PGR
13breast ductal adenoma10.4ERBB2, KRT5
14nasal cavity adenocarcinoma10.4ERBB2, PGR
15fallopian tube leiomyosarcoma10.4ERBB2, PGR
16pagod syndrome10.4AR, ERBB2
17nasal cavity squamous cell carcinoma10.4ERBB2, KRT5
18thymus adenocarcinoma10.4ERBB2, KRT5
19pituitary gland disease10.3ERBB2, ESR1
20eccrine acrospiroma10.3AR, PGR
21postpoliomyelitis syndrome10.3AR, PGR
22cribriform carcinoma10.3ERBB2, ESR1
23syringoma10.3ESR1, PGR
24endocrine organ benign neoplasm10.3ESR1, PGR
25cervical benign neoplasm10.3ESR1, PGR
26large bowel leiomyoma10.3ESR1, PGR
27bile duct cystadenoma10.3ESR1, PGR
28venous tributary occlusion of retina10.3ESR1, PGR
29deafness, autosomal dominant 8/1210.3ESR1, PGR
30peroneal nerve paralysis10.3ESR1, PGR
31vulvar squamous papilloma10.3ESR1, PGR
32extragonadal nonseminomatous germ cell tumor10.3ESR1, PGR
33vulvar alveolar soft part sarcoma10.3ESR1, PGR
34rectum mucinous adenocarcinoma10.3ESR1, PGR
35follicular basal cell carcinoma10.3ESR1, PGR
36breast granular cell tumor10.3ERBB2, ESR1
37childhood mediastinal neurogenic tumor10.3ESR1, PGR
38uterine corpus adenosarcoma10.3ESR1, PGR
39sciatic neuropathy10.3ESR1, PGR
40paroxysmal choreoathetosis10.3AR, ERBB2
41intraventricular meningioma10.3ESR1, PGR
42large cell acanthoma10.3ESR1, PGR
43breast metaplastic carcinoma10.3ESR1, PGR
44internal auditory canal lipoma10.3ESR1, PGR
45suppurative thyroiditis10.2ESR1, PGR
46adenosarcoma of the uterus10.2ESR1, PGR
47splenic disease10.2AR, ERBB2
48thymus lipoma10.2ESR1, PGR
49sensory organ benign neoplasm10.2ESR1, PGR
50pancreatic invasive mucinous cystadenocarcinoma10.2ESR1, PGR

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to apocrine adenocarcinoma

Symptoms for Apocrine Adenocarcinoma

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Drugs & Therapeutics for Apocrine Adenocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

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Anatomical Context for Apocrine Adenocarcinoma

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MalaCards organs/tissues related to Apocrine Adenocarcinoma:

33
Breast, Skin, Ovary, Endothelial, Thymus, Kidney, Pituitary

Animal Models for Apocrine Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9AR, ERBB2, ESR1, PGR
2MP:00053798.4AR, ERBB2, ESR1, HPGD, PGR
3MP:00053898.3AR, ERBB2, ESR1, HPGD, PGR
4MP:00053718.3AR, ERBB2, ESR1, KRT5, PGR
5MP:00053858.1AR, ERBB2, ESR1, HPGD, PGR
6MP:00107717.5AR, ERBB2, ESR1, KRT5, MLPH, PGR
7MP:00053767.2AR, ERBB2, ESR1, HPGD, MLPH, PGR
8MP:00107686.4AR, ERBB2, ESR1, HPGD, KRT5, MLPH

Publications for Apocrine Adenocarcinoma

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Articles related to Apocrine Adenocarcinoma:

(show all 37)
idTitleAuthorsYear
1
Axillary apocrine adenocarcinoma in a young male suspected initially on fine-needle aspiration cytology. (26729983)
2015
2
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report. (26375389)
2015
3
Primary apocrine adenocarcinoma of the axilla. (26057510)
2015
4
Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma. (25657556)
2015
5
Apocrine adenocarcinoma of the vulva. (24179652)
2013
6
Apocrine adenocarcinoma of the eyelid: case series and review. (24217473)
2013
7
Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma. (23863550)
2013
8
Primary apocrine adenocarcinoma of the eyelid. (22571743)
2012
9
Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. (21913192)
2012
10
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation. (19784530)
2009
11
Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. (18842349)
2009
12
Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. (19796468)
2009
13
Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. (18631226)
2008
14
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. (18982051)
2008
15
Apocrine adenocarcinoma of the nipple: a case report. (18700029)
2008
16
Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. (18713586)
2008
17
Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. (17375797)
2007
18
Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. (16961473)
2006
19
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. (15677547)
2005
20
Primary apocrine adenocarcinoma with neuroendocrine differentiation occurring on the pubic skin. (14996118)
2004
21
Apocrine adenocarcinoma of the nipple: a case report. (15469170)
2004
22
Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma). (11992376)
2002
23
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case. (11940224)
2002
24
Apocrine adenocarcinoma in a golden hamster. (11767064)
2001
25
Radiologic case study. Apocrine adenocarcinoma. (9845457)
1998
26
Apocrine adenocarcinoma presenting as a large ulcerated axillary mass. (9236879)
1997
27
Parathyroid hormone/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy. (9135577)
1997
28
A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. (8037297)
1994
29
Apocrine adenocarcinoma arising in cystic teratoma of the ovary. (8503739)
1993
30
Apocrine adenocarcinoma arising in Moll gland cystadenoma. (8233400)
1993
31
Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. (1510222)
1992
32
Apocrine adenocarcinoma of the bilateral axillae. (1785351)
1991
33
Apocrine adenocarcinoma: case report and review of the literature. (2341662)
1990
34
Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. (2175320)
1990
35
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. (2345942)
1990
36
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. (6322492)
1984
37
Paget's disease of the vulva with underlying apocrine adenocarcinoma and local lymph node invasion. (6269104)
1981

Variations for Apocrine Adenocarcinoma

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Expression for genes affiliated with Apocrine Adenocarcinoma

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Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for genes affiliated with Apocrine Adenocarcinoma

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Pathways related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4ESR1, PGR
2
Show member pathways
9.3AR, ESR1
39.0AR, ERBB2, ESR1
4
Show member pathways
8.9AR, ESR1, PGR

GO Terms for genes affiliated with Apocrine Adenocarcinoma

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Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:00063678.9AR, ESR1, PGR
2gene expressionGO:00104678.9AR, ESR1, PGR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin bindingGO:00080139.3AR, ESR1

Sources for Apocrine Adenocarcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet