MCID: APC004
MIFTS: 36

Apocrine Adenocarcinoma malady

Categories: Rare diseases, Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Apocrine Adenocarcinoma

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Aliases & Descriptions for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 10 12 65
Apocrine Carcinoma 10 45
Carcinoma of the Apocrine Gland 10
 
Carcinoma of Apocrine Gland 65
Apocrine Gland Carcinoma 10

Classifications:



External Ids:

Disease Ontology10 DOID:4933
SNOMED-CT59 57141000
UMLS65 C0334346, C1706827

Summaries for Apocrine Adenocarcinoma

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NIH Rare Diseases:45 Apocrine carcinoma is a cancer of a sweat gland.  apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  the cause of apocrine carcinoma is unknown.  apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  the average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  most apocrine carcinomas can be treated and are not fatal.  treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven. last updated: 6/16/2014

MalaCards based summary: Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to breast cancer and vulvar apocrine adenocarcinoma. An important gene associated with Apocrine Adenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways are Nuclear signaling by ERBB4 and FOXA1 transcription factor network. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Disease Ontology:10 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

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Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer28.8AR, ERBB2, ESR1, KRT5, PGR
2vulvar apocrine adenocarcinoma12.5
3breast apocrine carcinoma12.4
4breast apocrine carcinoma in situ12.4
5adenofibroma10.4ERBB2, PGR
6her2-receptor positive breast cancer10.3ERBB2, PGR
7ovarian mesodermal adenosarcoma10.3ERBB2, PGR
8acute retinal necrosis syndrome10.3ERBB2, PGR
9papillary carcinoma10.3ERBB2, PGR
10synchronous bilateral breast carcinoma10.3ERBB2, PGR
11peritoneal cystic mesothelioma10.3ERBB2, PGR
12breast ductal adenoma10.3ERBB2, KRT5
13nasal cavity adenocarcinoma10.3ERBB2, PGR
14fallopian tube leiomyosarcoma10.3ERBB2, PGR
15pagod syndrome10.3AR, ERBB2
16nasal cavity squamous cell carcinoma10.3ERBB2, KRT5
17cystadenoma10.2KRT5, PGR
18thymus adenocarcinoma10.2ERBB2, KRT5
19pituitary gland disease10.2ERBB2, ESR1
20eccrine acrospiroma10.2AR, PGR
21postpoliomyelitis syndrome10.2AR, PGR
22cribriform carcinoma10.2ERBB2, ESR1
23syringoma10.2ESR1, PGR
24endocrine organ benign neoplasm10.2ESR1, PGR
25cervical benign neoplasm10.2ESR1, PGR
26large bowel leiomyoma10.2ESR1, PGR
27bile duct cystadenoma10.2ESR1, PGR
28venous tributary occlusion of retina10.2ESR1, PGR
29deafness, autosomal dominant 8/1210.2ESR1, PGR
30peroneal nerve paralysis10.2ESR1, PGR
31vulvar squamous papilloma10.2ESR1, PGR
32extragonadal nonseminomatous germ cell tumor10.2ESR1, PGR
33vulvar alveolar soft part sarcoma10.2ESR1, PGR
34rectum mucinous adenocarcinoma10.2ESR1, PGR
35follicular basal cell carcinoma10.2ESR1, PGR
36breast granular cell tumor10.2ERBB2, ESR1
37childhood mediastinal neurogenic tumor10.2ESR1, PGR
38uterine corpus adenosarcoma10.2ESR1, PGR
39sciatic neuropathy10.2ESR1, PGR
40paroxysmal choreoathetosis10.2AR, ERBB2
41intraventricular meningioma10.2ESR1, PGR
42large cell acanthoma10.2ESR1, PGR
43breast metaplastic carcinoma10.2ESR1, PGR
44internal auditory canal lipoma10.2ESR1, PGR
45suppurative thyroiditis10.2ESR1, PGR
46tuberculosis10.2
47adenosarcoma of the uterus10.2ESR1, PGR
48splenic disease10.2AR, ERBB2
49thymus lipoma10.2ESR1, PGR
50sensory organ benign neoplasm10.1ESR1, PGR

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to apocrine adenocarcinoma

Symptoms for Apocrine Adenocarcinoma

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Drugs & Therapeutics for Apocrine Adenocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

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Anatomical Context for Apocrine Adenocarcinoma

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MalaCards organs/tissues related to Apocrine Adenocarcinoma:

33
Skin, Liver, Kidney, Bone marrow, Salivary gland, Monocytes, Endothelial

Animal Models for Apocrine Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.9AR, ERBB2, ESR1, PGR
2MP:00053798.4AR, ERBB2, ESR1, HPGD, PGR
3MP:00053898.3AR, ERBB2, ESR1, HPGD, PGR
4MP:00053718.3AR, ERBB2, ESR1, KRT5, PGR
5MP:00053858.1AR, ERBB2, ESR1, HPGD, PGR
6MP:00107717.5AR, ERBB2, ESR1, KRT5, MLPH, PGR
7MP:00053767.2AR, ERBB2, ESR1, HPGD, MLPH, PGR
8MP:00107686.4AR, ERBB2, ESR1, HPGD, KRT5, MLPH

Publications for Apocrine Adenocarcinoma

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Articles related to Apocrine Adenocarcinoma:

(show all 36)
idTitleAuthorsYear
1
Testicular yolk sac tumor and impaired spermatogenesis in a Holstein Friesian calf. (26214222)
2015
2
Variations in erythropoiesis-stimulating agent administration in transfusion-dependent myelodysplastic syndromes impact response. (25869077)
2015
3
A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor. (24523241)
2014
4
Diabetes is an independent risk factor for peptic ulcer bleeding: a nationwide population-based cohort study. (23488965)
2013
5
Simultaneous quantification of nucleoproteins and comparison of methyl green-pyronin Y and Feulgen staining in sections of oral squamous cell carcinoma, dysplastic lesions and normal mucosa. (24219353)
2013
6
Crimean-Congo hemorrhagic fever: an overview. (23913177)
2013
7
Double-barrel extracranial-intracranial bypass surgery followed by endovascular carotid artery occlusion in a patient with an extracranial giant internal carotid artery aneurysm due to Ehlers-Danlos syndrome. (22993245)
2013
8
TLR4-dependant immune response, but not hepatitis B virus reactivation, is important in radiation-induced liver disease of liver cancer radiotherapy. (24337704)
2013
9
Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (22282338)
2012
10
Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion. (23271156)
2012
11
Graft rejection in pediatric liver transplant patients with Epstein-Barr viremia and post-transplant lymphoproliferative disease. (22554096)
2012
12
Increased cell apoptosis of urothelium mediated by inflammation in interstitial cystitis/painful bladder syndrome. (22310775)
2012
13
Disproportionate pulmonary hypertension in a patient with early-onset pulmonary emphysema treated with specific drugs for pulmonary arterial hypertension. (22001462)
2011
14
In Lysinuric Protein Intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophages. (21110863)
2010
15
Inflammatory cytokines in saliva: early signs of metabolic disorders in chronic kidney disease. A controlled cross-sectional study. (20955949)
2010
16
Travel and implications for the elimination of trachoma in ethiopia. (20302432)
2010
17
Loss of SFRP1 expression is associated with aberrant beta-catenin distribution and tumor progression in mucoepidermoid carcinoma of salivary glands. (20162454)
2010
18
Diagnostic dilemma of a subcutaneous nodule following a trauma in a child: immunohistochemical examination put the final diagnosis of deep granuloma annulare. (20012241)
2010
19
Evidence of cognitive and neurophysiological impairment in patients with untreated naive acromegaly. (20554710)
2010
20
High-resolution melting analysis for the rapid detection of an intronic single nucleotide polymorphism in SLC22A12 in male patients with primary gout in China. (19306160)
2009
21
Cerebral phaeohyphomycosis--a cure at what lengths? (19467477)
2009
22
Empty follicle syndrome in the setting of dramatic weight loss after bariatric surgery: case report and review of available literature. (18083168)
2008
23
Application of tandem mass spectrometry on the diagnosis of fatty acid oxidation disorders]. (18067086)
2007
24
Splenic abscess secondary to a colosplenic fistula in Crohn's disease. (17685263)
2007
25
Autoantibodies to human manganese superoxide dismutase (MnSOD) in children with facial palsy due to neuroborreliosis. (16429379)
2005
26
The expression and function of cathepsin E in dendritic cells. (15699105)
2005
27
Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells. (15062106)
2004
28
Cloning and expression analysis of the murine homolog of the spinocerebellar ataxia type 7 (SCA7) gene. (12039035)
2002
29
Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response. (11595723)
2001
30
Disseminated BCG infection following bone marrow transplantation for X-linked severe combined immunodeficiency. (10886754)
2000
31
Diabetes mellitus in young Thai adults. (11215856)
2000
32
A molecular epidemiology study in women from Upper Silesia, Poland. (9820667)
1998
33
An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene. (8885870)
1996
34
Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells. (7983032)
1994
35
Double outlet right ventricle in a human embryo. (151978)
1978
36
Congenital lactase deficiency. (5946649)
1966

Variations for Apocrine Adenocarcinoma

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Expression for genes affiliated with Apocrine Adenocarcinoma

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Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for genes affiliated with Apocrine Adenocarcinoma

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Pathways related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4ESR1, PGR
2
Show member pathways
9.3AR, ESR1
39.0AR, ERBB2, ESR1
4
Show member pathways
8.9AR, ESR1, PGR

GO Terms for genes affiliated with Apocrine Adenocarcinoma

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Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription initiation from RNA polymerase II promoterGO:00063678.9AR, ESR1, PGR
2gene expressionGO:00104678.9AR, ESR1, PGR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin bindingGO:00080139.3AR, ESR1

Sources for Apocrine Adenocarcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet