MCID: APC004
MIFTS: 39

Apocrine Adenocarcinoma malady

Categories: Rare diseases, Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Apocrine Adenocarcinoma

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Aliases & Descriptions for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 11 13 68
Apocrine Carcinoma 11 48
Carcinoma of the Apocrine Gland 11
 
Carcinoma of Apocrine Gland 68
Apocrine Gland Carcinoma 11

Classifications:



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Disease Ontology11 DOID:4933
SNOMED-CT62 57141000

Summaries for Apocrine Adenocarcinoma

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NIH Rare Diseases:48 Apocrine carcinoma is a cancer of a sweat gland.  apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  the cause of apocrine carcinoma is unknown.  apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  the average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  most apocrine carcinomas can be treated and are not fatal.  treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven. last updated: 6/16/2014

MalaCards based summary: Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to vulvar apocrine adenocarcinoma and breast apocrine carcinoma. An important gene associated with Apocrine Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways are FOXA1 transcription factor network and Signaling by ERBB4. Affiliated tissues include skin, lymph node and breast, and related mouse phenotypes are neoplasm and integument.

Disease Ontology:11 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

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Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar apocrine adenocarcinoma12.1
2breast apocrine carcinoma12.0
3breast apocrine carcinoma in situ11.9
4adenocarcinoma10.5
5breast sarcoma10.3ERBB2, PIP
6vulvar angiokeratoma10.2MUC1, PIP
7lacrimal gland mucoepidermoid carcinoma10.2MUC1, PGR
8vulva squamous cell carcinoma10.2ERBB2, PIP
9mouth disease10.2ERBB2, PGR
10exotropia10.2MUC1, PGR
11marfanoid hypermobility syndrome10.2MUC1, PGR
12myotonia congenita10.2ERBB2, PIP
13endometrial stromal sarcoma10.2MUC1, PGR
14reticulosarcoma10.2AR, PIP
15porokeratosis10.2MUC1, PGR
16mucoepidermoid thyroid carcinoma10.2ERBB2, PGR
17papilloma10.2MUC1, PGR
18triple-receptor negative breast cancer10.2ERBB2, PGR
19skin sarcoma10.2ERBB2, PGR
20intestinal neuroendocrine benign tumor10.2ERBB2, PGR
21nipple neoplasm10.2MUC1, PGR
22basaloid squamous cell carcinoma10.2ERBB2, PGR
23sebaceous adenoma10.2MUC1, PGR
24infiltrating angiolipoma10.2ERBB2, PGR
25mesenchymoma10.2MUC1, PGR
26nasal cavity adenocarcinoma10.2ERBB2, MUC1
27perinatal necrotizing enterocolitis10.2MUC1, PGR
28reactive arthritis10.2ERBB2, PGR
29tubular adenocarcinoma10.2ESR1, PIP
30spastic diplegia infantile type10.1ERBB2, MUC1
31hereditary breast ovarian cancer10.1ERBB2, ESR1
32bartholin's gland benign neoplasm10.1ESR1, PGR
33vulvar squamous papilloma10.1ESR1, MUC1
34cardiovascular organ benign neoplasm10.1ESR1, PGR
35appendix leiomyoma10.1ESR1, PGR
36bowman's membrane folds or rupture10.1AR, PGR
37bronchus adenoma10.1ESR1, PGR
38ovarian benign neoplasm10.1ESR1, PGR
39plexiform neurofibroma10.1ESR1, PGR
40paranasal sinus disease10.1ESR1, PGR
41deafness, autosomal recessive 2110.1ESR1, PGR
42atypical lipomatous tumor10.1ESR1, PGR
43pediatric intraocular retinoblastoma10.1ESR1, PGR
44congenital disorder of glycosylation, type ic10.1ESR1, PGR
45intestinal perforation10.1ESR1, PGR
46perlman syndrome10.1ESR1, PGR
47congenital articular rigidity10.1AR, MUC1
48vulva basal cell carcinoma10.1ESR1, PGR
49villoglandular endometrial endometrioid adenocarcinoma10.1ESR1, PGR
50vaginal adenosarcoma10.1ESR1, PGR

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to apocrine adenocarcinoma

Symptoms & Phenotypes for Apocrine Adenocarcinoma

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MGI Mouse Phenotypes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.2AR, ERBB2, ESR1, PGR
2MP:00107718.7AR, ERBB2, ESR1, MLPH, PGR
3MP:00053858.1AR, ERBB2, ESR1, HPGD, PGR, PIP
4MP:00053798.1AR, ERBB2, ESR1, HPGD, PGR, PIP
5MP:00053897.3AR, ERBB2, ESR1, HPGD, PGR, PIP

Drugs & Therapeutics for Apocrine Adenocarcinoma

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Drugs for Apocrine Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Axitinibapproved, investigationalPhase 2109319460-85-06450551
Synonyms:
319460-85-0
790713-39-2
AC-1539
AC1O51X3
AG 013736
AG-013736
AG-013736, Axitinib
AG-13736
AG013736
Axitinib
C503983
CID6450551
 
EC-000.2322
I14-1971
INLYTA
Inlyta
MolPort-006-392-413
N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
S1005_Selleck
ST51054130
UNII-C9LVQ0YUXG
ZINC03816287
axitinib
axitinibum
2
nivolumabapprovedPhase 2424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
3Protein Kinase InhibitorsPhase 23689
4ImmunoglobulinsPhase 26394
5AntibodiesPhase 26394
6Antibodies, MonoclonalPhase 24039

Interventional clinical trials:

idNameStatusNCT IDPhase
1Axitinib in R/M Salivary Gland Cancers of the Upper Aerodigestive Tract - SGC-AX14RecruitingNCT02857712Phase 2
2Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin CancersNot yet recruitingNCT02978625Phase 2

Search NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

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Anatomical Context for Apocrine Adenocarcinoma

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MalaCards organs/tissues related to Apocrine Adenocarcinoma:

36
Skin, Lymph node, Breast, Ovary

Publications for Apocrine Adenocarcinoma

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Articles related to Apocrine Adenocarcinoma:

(show all 40)
idTitleAuthorsYear
1
Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases. (27818816)
2016
2
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. (27668109)
2016
3
Apocrine adenocarcinoma of the eyelid. (27500123)
2016
4
Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma. (25657556)
2015
5
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report. (26375389)
2015
6
Axillary apocrine adenocarcinoma in a young male suspected initially on fine-needle aspiration cytology. (26729983)
2015
7
Primary apocrine adenocarcinoma of the axilla. (26057510)
2015
8
Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma. (23863550)
2013
9
Apocrine adenocarcinoma of the vulva. (24179652)
2013
10
Apocrine adenocarcinoma of the eyelid: case series and review. (24217473)
2013
11
Primary apocrine adenocarcinoma of the eyelid. (22571743)
2012
12
Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. (21913192)
2012
13
Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. (18842349)
2009
14
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation. (19784530)
2009
15
Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. (19796468)
2009
16
Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. (18631226)
2008
17
Apocrine adenocarcinoma of the nipple: a case report. (18700029)
2008
18
Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. (18713586)
2008
19
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. (18982051)
2008
20
Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. (17375797)
2007
21
Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. (16961473)
2006
22
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. (15677547)
2005
23
Apocrine adenocarcinoma of the nipple: a case report. (15469170)
2004
24
Primary apocrine adenocarcinoma with neuroendocrine differentiation occurring on the pubic skin. (14996118)
2004
25
Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma). (11992376)
2002
26
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case. (11940224)
2002
27
Apocrine adenocarcinoma in a golden hamster. (11767064)
2001
28
Radiologic case study. Apocrine adenocarcinoma. (9845457)
1998
29
Parathyroid hormone/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy. (9135577)
1997
30
Apocrine adenocarcinoma presenting as a large ulcerated axillary mass. (9236879)
1997
31
A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. (8037297)
1994
32
Apocrine adenocarcinoma arising in cystic teratoma of the ovary. (8503739)
1993
33
Apocrine adenocarcinoma arising in Moll gland cystadenoma. (8233400)
1993
34
Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. (1510222)
1992
35
Apocrine adenocarcinoma of the bilateral axillae. (1785351)
1991
36
Apocrine adenocarcinoma: case report and review of the literature. (2341662)
1990
37
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. (2345942)
1990
38
Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. (2175320)
1990
39
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. (6322492)
1984
40
Paget's disease of the vulva with underlying apocrine adenocarcinoma and local lymph node invasion. (6269104)
1981

Variations for Apocrine Adenocarcinoma

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Expression for genes affiliated with Apocrine Adenocarcinoma

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Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for genes affiliated with Apocrine Adenocarcinoma

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GO Terms for genes affiliated with Apocrine Adenocarcinoma

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Cellular components related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163249.9ERBB2, MUC1, PIP
2nuclear chromatinGO:00007909.0AR, ESR1, MUC1

Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase III promoterGO:004594510.1AR, ERBB2
2tertiary branching involved in mammary gland duct morphogenesisGO:006074810.1AR, PGR
3intracellular receptor signaling pathwayGO:003052210.0AR, ESR1
4mammary gland alveolus developmentGO:006074910.0AR, ESR1
5positive regulation of gene expressionGO:00106289.8AR, ERBB2, PIP
6steroid hormone mediated signaling pathwayGO:00434019.4AR, ESR1, PGR
7transcription initiation from RNA polymerase II promoterGO:00063678.9AR, ESR1, PGR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein dimerization activityGO:00469839.8AR, ERBB2, PIP
2ATPase bindingGO:00511179.6AR, ESR1, PGR
3lipid bindingGO:00082899.6AR, ESR1, PGR
4RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:00048799.5AR, ESR1, PGR
5steroid bindingGO:00054969.5AR, ESR1, PGR
6steroid hormone receptor activityGO:00037079.5AR, ESR1, PGR
7RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.2AR, ESR1, MUC1, PGR
8transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010778.9AR, ESR1, PGR

Sources for Apocrine Adenocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet