MCID: APC004
MIFTS: 36

Apocrine Adenocarcinoma malady

Rare diseases, Cancer diseases, Endocrine diseases categories

Aliases & Classifications for Apocrine Adenocarcinoma

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Aliases & Descriptions for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 10 12 65
Apocrine Carcinoma 10 45
Carcinoma of the Apocrine Gland 10
 
Carcinoma of Apocrine Gland 65
Apocrine Gland Carcinoma 10


Classifications:



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Disease Ontology10 DOID:4933
SNOMED-CT59 57141000

Summaries for Apocrine Adenocarcinoma

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NIH Rare Diseases:45 Apocrine carcinoma is a cancer of a sweat gland.  apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  the cause of apocrine carcinoma is unknown.  apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  the average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  most apocrine carcinomas can be treated and are not fatal.  treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven. last updated: 6/16/2014

MalaCards based summary: Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to cellulitis and breast cancer. An important gene associated with Apocrine Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways is EGFR Signaling Pathway. Affiliated tissues include lymph node, breast and ovary, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Disease Ontology:10 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

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Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1cellulitis29.8AR, ERBB2, MUC1, PGR
2breast cancer29.5AR, ERBB2, MUC1, PGR, PIP
3adenocarcinoma10.9
4vulvar apocrine adenocarcinoma10.5
5breast apocrine carcinoma10.5
6breast apocrine carcinoma in situ10.4
7sweat gland carcinoma10.4
8neuroendocrine carcinoma10.3
9apocrine adenoma10.3
10adenoma10.3
11lipid-rich carcinoma10.3
12gynecomastia10.2
13vulvar nodular hidradenoma10.2MUC1, PIP
14epidermolytic acanthoma10.2ERBB2, PIP
15vulvar trichoepithelioma10.2ERBB2, PIP
16vulva cancer10.2ERBB2, PIP
17scrotum basal cell carcinoma10.2ERBB2, MUC1
18high molecular weight kininogen deficiency10.2ERBB2, PIP
19breast granular cell tumor10.2ERBB2, MUC1
20splenic artery aneurysm10.2MUC1, PGR
21malignant teratocarcinosarcoma10.2MUC1, PGR
22endometriosis of intestine10.2MUC1, PGR
23primary hypertrophic osteoarthropathy10.2MUC1, PGR
24rift valley fever10.2MUC1, PGR
25mixed germ cell-sex cord neoplasm10.2MUC1, PGR
26glaucoma iridogoniodysgenesia10.2ERBB2, PGR
27enophthalmos10.2ERBB2, PGR
28breast mucinous carcinoma10.2ERBB2, PGR
29estrogen-receptor negative breast cancer10.1ERBB2, PGR
30pituitary hypoplasia10.1MUC1, PGR
31papillary extrahepatic bile duct adenocarcinoma10.1ERBB2, PGR
32uterine corpus cancer10.1ERBB2, PGR
33cystadenoma10.1
34breast adenocarcinoma10.1
35cystic teratoma10.1
36teratoma10.1
37microscopic colitis10.1ERBB2, PGR
38adrenal rest tumor10.1MUC1, PGR
39breast leiomyosarcoma10.1ERBB2, PGR
40pediatric cns embryonal cell carcinoma10.1MUC1, PGR
41cystic kidney10.1AR, MUC1
42complete atrioventricular canal10.1AR, MUC1
43breast myoepitheliosis10.1ERBB2, PGR
44uterine corpus cellular leiomyoma10.1ERBB2, PGR
45kidney cortex necrosis10.1ERBB2, PGR
46vaginal adenosarcoma10.1ERBB2, PGR
47lateral medullary syndrome10.1ERBB2, PGR
48adolescence-adult electroclinical syndrome10.1ERBB2, PGR
49adult liposarcoma10.1MUC1, PGR
50follicular dendritic cell sarcoma10.1ERBB2, PGR

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to apocrine adenocarcinoma

Symptoms for Apocrine Adenocarcinoma

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Drugs & Therapeutics for Apocrine Adenocarcinoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

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Anatomical Context for Apocrine Adenocarcinoma

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MalaCards organs/tissues related to Apocrine Adenocarcinoma:

33
Lymph node, Breast, Ovary, Skin

Animal Models for Apocrine Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8AR, ERBB2, MUC1, PIP
2MP:00020068.7AR, ERBB2, MUC1, PGR
3MP:00053858.1AR, ERBB2, HPGD, PGR, PIP
4MP:00107718.0AR, ERBB2, MLPH, MUC1, PGR
5MP:00053897.6AR, ERBB2, HPGD, PGR, PIP
6MP:00053797.6AR, ERBB2, HPGD, MUC1, PGR, PIP
7MP:00053767.3AR, ERBB2, HPGD, MLPH, MUC1, PGR

Publications for Apocrine Adenocarcinoma

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Articles related to Apocrine Adenocarcinoma:

(show all 36)
idTitleAuthorsYear
1
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report. (26375389)
2015
2
Primary apocrine adenocarcinoma of the axilla. (26057510)
2015
3
Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma. (25657556)
2015
4
Apocrine adenocarcinoma of the vulva. (24179652)
2013
5
Apocrine adenocarcinoma of the eyelid: case series and review. (24217473)
2013
6
Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma. (23863550)
2013
7
Primary apocrine adenocarcinoma of the eyelid. (22571743)
2012
8
Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. (21913192)
2012
9
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation. (19784530)
2009
10
Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. (18842349)
2009
11
Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. (19796468)
2009
12
Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. (18631226)
2008
13
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. (18982051)
2008
14
Apocrine adenocarcinoma of the nipple: a case report. (18700029)
2008
15
Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. (18713586)
2008
16
Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. (17375797)
2007
17
Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. (16961473)
2006
18
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. (15677547)
2005
19
Primary apocrine adenocarcinoma with neuroendocrine differentiation occurring on the pubic skin. (14996118)
2004
20
Apocrine adenocarcinoma of the nipple: a case report. (15469170)
2004
21
Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma). (11992376)
2002
22
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case. (11940224)
2002
23
Apocrine adenocarcinoma in a golden hamster. (11767064)
2001
24
Radiologic case study. Apocrine adenocarcinoma. (9845457)
1998
25
Apocrine adenocarcinoma presenting as a large ulcerated axillary mass. (9236879)
1997
26
Parathyroid hormone/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy. (9135577)
1997
27
A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. (8037297)
1994
28
Apocrine adenocarcinoma arising in cystic teratoma of the ovary. (8503739)
1993
29
Apocrine adenocarcinoma arising in Moll gland cystadenoma. (8233400)
1993
30
Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. (1510222)
1992
31
Apocrine adenocarcinoma of the bilateral axillae. (1785351)
1991
32
Apocrine adenocarcinoma: case report and review of the literature. (2341662)
1990
33
Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. (2175320)
1990
34
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. (2345942)
1990
35
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. (6322492)
1984
36
Paget's disease of the vulva with underlying apocrine adenocarcinoma and local lymph node invasion. (6269104)
1981

Variations for Apocrine Adenocarcinoma

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Expression for genes affiliated with Apocrine Adenocarcinoma

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Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for genes affiliated with Apocrine Adenocarcinoma

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Pathways related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ERBB2, MUC1

GO Terms for genes affiliated with Apocrine Adenocarcinoma

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Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tertiary branching involved in mammary gland duct morphogenesisGO:00607489.9AR, PGR
2positive regulation of transcription from RNA polymerase III promoterGO:00459459.5AR, ERBB2
3steroid hormone mediated signaling pathwayGO:00434019.2AR, PGR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:000370710.0AR, PGR
2RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:000487910.0AR, PGR
3glycoprotein bindingGO:00019489.5ERBB2, PIP
4steroid bindingGO:00054969.5AR, PGR
5ATPase bindingGO:00511179.5AR, PGR
6RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.0AR, MUC1, PGR
7protein dimerization activityGO:00469838.6AR, ERBB2, PIP

Sources for Apocrine Adenocarcinoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet