MCID: APC004
MIFTS: 38

Apocrine Adenocarcinoma malady

Categories: Rare diseases, Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Apocrine Adenocarcinoma

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Aliases & Descriptions for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 11 13 66
Apocrine Carcinoma 11 46
Carcinoma of the Apocrine Gland 11
 
Carcinoma of Apocrine Gland 66
Apocrine Gland Carcinoma 11

Classifications:



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Disease Ontology11 DOID:4933
SNOMED-CT60 57141000

Summaries for Apocrine Adenocarcinoma

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NIH Rare Diseases:46 Apocrine carcinoma is a cancer of a sweat gland.  apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  the cause of apocrine carcinoma is unknown.  apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  the average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  most apocrine carcinomas can be treated and are not fatal.  treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven. last updated: 6/16/2014

MalaCards based summary: Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to vulvar apocrine adenocarcinoma and breast apocrine carcinoma. An important gene associated with Apocrine Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways are Nuclear signaling by ERBB4 and FOXA1 transcription factor network. Affiliated tissues include skin, salivary gland and breast, and related mouse phenotypes are neoplasm and limbs/digits/tail.

Disease Ontology:11 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

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Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar apocrine adenocarcinoma12.2
2breast apocrine carcinoma12.2
3breast apocrine carcinoma in situ12.0
4adenocarcinoma10.6
5breast granular cell tumor10.5ERBB2, PIP
6syringoma10.5MUC1, PIP
7heel spur10.5ERBB2, PIP
8vulva squamous cell carcinoma10.5ERBB2, PIP
9thymus adenocarcinoma10.4ESR1, PIP
10breast papillary carcinoma10.4ERBB2, MUC1
11breast metaplastic carcinoma10.4MUC1, PGR
12endometriosis of pelvic peritoneum10.4MUC1, PGR
13bronchiolo-alveolar adenocarcinoma10.4ERBB2, MUC1
14congenital structural myopathy10.4MUC1, PGR
15central centrifugal cicatricial alopecia10.4ERBB2, MUC1
16adenomyosis10.4ERBB2, MUC1
17bartholin's gland benign neoplasm10.4ESR1, MUC1
18eyelid disease10.4ERBB2, ESR1
19serous surface papilloma10.4MUC1, PGR
20ossifying fibromyxoid tumor10.4ERBB2, PGR
21cutaneous mucoepidermoid carcinoma10.4ERBB2, PGR
22her2-receptor negative breast cancer10.4ERBB2, PGR
23benign mesenchymoma10.4MUC1, PGR
24extragonadal nonseminomatous germ cell tumor10.3ERBB2, ESR1
25acute pulmonary heart disease10.3AR, PIP
26animal phobia10.3ERBB2, PGR
27parachordoma10.3MUC1, PGR
28vaginal adenosarcoma10.3ERBB2, PGR
29postcricoid region cancer10.3MUC1, PGR
30focal chorioretinitis10.3ERBB2, PGR
31retinitis10.3ERBB2, PGR
32vulvar angiokeratoma10.3ESR1, PGR
33central nervous system organ benign neoplasm10.3ESR1, PGR
34fallopian tube benign neoplasm10.3ESR1, PGR
35appendix leiomyoma10.3ESR1, PGR
36pancreas lymphoma10.3ESR1, MUC1
37mixed cell adenoma10.3ESR1, PGR
38tuberous sclerosis10.3ESR1, PGR
39deafness, autosomal dominant 8/1210.3ESR1, PGR
40dental enamel hypoplasia10.3ESR1, PGR
41perinatal intestinal perforation10.3ESR1, PGR
42breast pericanalicular fibroadenoma10.3MUC1, PGR
43asthma susceptibility 510.3ESR1, PGR
44ovarian small cell carcinoma10.3ERBB2, PGR
45amyloid tumor10.3ESR1, PGR
46malignant mediastinal neurogenic neoplasm10.3ESR1, PGR
47chronic interstitial cystitis10.3MUC1, PGR
48uterine body mixed cancer10.3ESR1, PGR
49infiltrative basal cell carcinoma10.3ESR1, PGR
50fallopian tube germ cell cancer10.3ESR1, PGR

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to apocrine adenocarcinoma

Symptoms for Apocrine Adenocarcinoma

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Drugs & Therapeutics for Apocrine Adenocarcinoma

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Drugs for Apocrine Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AxitinibPhase 2106319460-85-06450551
Synonyms:
319460-85-0
790713-39-2
AC-1539
AC1O51X3
AG 013736
AG-013736
AG-013736, Axitinib
AG-13736
AG013736
Axitinib
C503983
 
CID6450551
EC-000.2322
I14-1971
INLYTA
Inlyta
MolPort-006-392-413
N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
S1005_Selleck
ST51054130
UNII-C9LVQ0YUXG
ZINC03816287
axitinib

Interventional clinical trials:

idNameStatusNCT IDPhase
1Axitinib in R/M Salivary Gland Cancers of the Upper Aerodigestive Tract - SGC-AX14RecruitingNCT02857712Phase 2

Search NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

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Anatomical Context for Apocrine Adenocarcinoma

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MalaCards organs/tissues related to Apocrine Adenocarcinoma:

34
Skin, Salivary gland, Breast, Lymph node, Ovary

Animal Models for Apocrine Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3AR, ERBB2, ESR1, PGR
2MP:00053718.3AR, ERBB2, ESR1, PGR
3MP:00053897.3AR, ERBB2, ESR1, HPGD, PGR, PIP
4MP:00053847.3AR, ERBB2, ESR1, HPGD, PGR, PIP
5MP:00053857.0AR, ERBB2, ESR1, HPGD, PGR, PIP
6MP:00053796.8AR, ERBB2, ESR1, HPGD, PGR, PIP

Publications for Apocrine Adenocarcinoma

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Articles related to Apocrine Adenocarcinoma:

(show all 38)
idTitleAuthorsYear
1
Apocrine adenocarcinoma of the eyelid. (27500123)
2016
2
Axillary apocrine adenocarcinoma in a young male suspected initially on fine-needle aspiration cytology. (26729983)
2015
3
Primary apocrine adenocarcinoma of the axilla. (26057510)
2015
4
Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma. (25657556)
2015
5
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report. (26375389)
2015
6
Apocrine adenocarcinoma of the vulva. (24179652)
2013
7
Apocrine adenocarcinoma of the eyelid: case series and review. (24217473)
2013
8
Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma. (23863550)
2013
9
Primary apocrine adenocarcinoma of the eyelid. (22571743)
2012
10
Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. (21913192)
2012
11
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation. (19784530)
2009
12
Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. (18842349)
2009
13
Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. (19796468)
2009
14
Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. (18631226)
2008
15
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. (18982051)
2008
16
Apocrine adenocarcinoma of the nipple: a case report. (18700029)
2008
17
Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. (18713586)
2008
18
Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. (17375797)
2007
19
Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. (16961473)
2006
20
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. (15677547)
2005
21
Primary apocrine adenocarcinoma with neuroendocrine differentiation occurring on the pubic skin. (14996118)
2004
22
Apocrine adenocarcinoma of the nipple: a case report. (15469170)
2004
23
Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma). (11992376)
2002
24
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case. (11940224)
2002
25
Apocrine adenocarcinoma in a golden hamster. (11767064)
2001
26
Radiologic case study. Apocrine adenocarcinoma. (9845457)
1998
27
Parathyroid hormone/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy. (9135577)
1997
28
Apocrine adenocarcinoma presenting as a large ulcerated axillary mass. (9236879)
1997
29
A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. (8037297)
1994
30
Apocrine adenocarcinoma arising in cystic teratoma of the ovary. (8503739)
1993
31
Apocrine adenocarcinoma arising in Moll gland cystadenoma. (8233400)
1993
32
Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. (1510222)
1992
33
Apocrine adenocarcinoma of the bilateral axillae. (1785351)
1991
34
Apocrine adenocarcinoma: case report and review of the literature. (2341662)
1990
35
Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. (2175320)
1990
36
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. (2345942)
1990
37
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. (6322492)
1984
38
Paget's disease of the vulva with underlying apocrine adenocarcinoma and local lymph node invasion. (6269104)
1981

Variations for Apocrine Adenocarcinoma

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Expression for genes affiliated with Apocrine Adenocarcinoma

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Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for genes affiliated with Apocrine Adenocarcinoma

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Pathways related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.2ESR1, PGR
2
Show member pathways
9.1AR, ESR1
38.7AR, ERBB2, ESR1
4
Show member pathways
8.7AR, ESR1, PGR

GO Terms for genes affiliated with Apocrine Adenocarcinoma

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Cellular components related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163249.2ERBB2, MUC1, PIP
2nuclear chromatinGO:00007908.9AR, ESR1, MUC1

Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase III promoterGO:004594510.1AR, ERBB2
2mammary gland alveolus developmentGO:00607499.5AR, ESR1
3positive regulation of epithelial cell proliferationGO:00506799.4ERBB2, ESR1
4positive regulation of gene expressionGO:00106289.2AR, ERBB2, PIP
5transcription initiation from RNA polymerase II promoterGO:00063679.1AR, ESR1, PGR
6signal transductionGO:00071658.3AR, ERBB2, ESR1, PGR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:00037079.8ESR1, PGR
2RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:00048799.7AR, ESR1
3protein dimerization activityGO:00469839.2AR, ERBB2, PIP
4steroid bindingGO:00054969.0AR, ESR1, PGR
5transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010778.8AR, ESR1, PGR
6ATPase bindingGO:00511178.7AR, ESR1, PGR
7enzyme bindingGO:00198998.6AR, ESR1, PGR
8RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009788.4AR, ESR1, MUC1, PGR

Sources for Apocrine Adenocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet