MCID: APC004
MIFTS: 39

Apocrine Adenocarcinoma malady

Categories: Rare diseases, Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Apocrine Adenocarcinoma

Aliases & Descriptions for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 12 14 69
Apocrine Carcinoma 12 50
Carcinoma of the Apocrine Gland 12
Carcinoma of Apocrine Gland 69
Apocrine Gland Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4933
SNOMED-CT 64 57141000
UMLS 69 C0334346

Summaries for Apocrine Adenocarcinoma

NIH Rare Diseases : 50 apocrine carcinoma is a cancer of a sweat gland.  apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  the cause of apocrine carcinoma is unknown.  apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  the average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  most apocrine carcinomas can be treated and are not fatal.  treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven. last updated: 6/16/2014

MalaCards based summary : Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to vulvar apocrine adenocarcinoma and breast apocrine carcinoma. An important gene associated with Apocrine Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Glioma and Signaling by ERBB4. The drugs Axitinib and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and breast, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Disease Ontology : 12 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

Related Diseases for Apocrine Adenocarcinoma

Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
id Related Disease Score Top Affiliating Genes
1 vulvar apocrine adenocarcinoma 12.1
2 breast apocrine carcinoma 12.0
3 breast apocrine carcinoma in situ 11.9
4 adenocarcinoma 10.5
5 breast sarcoma 10.3 ERBB2 PIP
6 vulvar angiokeratoma 10.2 MUC1 PIP
7 lacrimal gland mucoepidermoid carcinoma 10.2 MUC1 PGR
8 vulva squamous cell carcinoma 10.2 ERBB2 PIP
9 mouth disease 10.2 ERBB2 PGR
10 exotropia 10.2 MUC1 PGR
11 marfanoid hypermobility syndrome 10.2 MUC1 PGR
12 myotonia congenita 10.2 ERBB2 PIP
13 endometrial stromal sarcoma 10.2 MUC1 PGR
14 reticulosarcoma 10.2 AR PIP
15 porokeratosis 10.2 MUC1 PGR
16 mucoepidermoid thyroid carcinoma 10.2 ERBB2 PGR
17 papilloma 10.2 MUC1 PGR
18 triple-receptor negative breast cancer 10.2 ERBB2 PGR
19 skin sarcoma 10.2 ERBB2 PGR
20 intestinal neuroendocrine benign tumor 10.2 ERBB2 PGR
21 nipple neoplasm 10.2 MUC1 PGR
22 basaloid squamous cell carcinoma 10.2 ERBB2 PGR
23 sebaceous adenoma 10.2 MUC1 PGR
24 infiltrating angiolipoma 10.2 ERBB2 PGR
25 mesenchymoma 10.2 MUC1 PGR
26 nasal cavity adenocarcinoma 10.2 ERBB2 MUC1
27 perinatal necrotizing enterocolitis 10.2 MUC1 PGR
28 reactive arthritis 10.2 ERBB2 PGR
29 tubular adenocarcinoma 10.2 ESR1 PIP
30 spastic diplegia infantile type 10.1 ERBB2 MUC1
31 hereditary breast ovarian cancer 10.1 ERBB2 ESR1
32 bartholin's gland benign neoplasm 10.1 ESR1 PGR
33 vulvar squamous papilloma 10.1 ESR1 MUC1
34 cardiovascular organ benign neoplasm 10.1 ESR1 PGR
35 appendix leiomyoma 10.1 ESR1 PGR
36 bowman's membrane folds or rupture 10.1 AR PGR
37 bronchus adenoma 10.1 ESR1 PGR
38 ovarian benign neoplasm 10.1 ESR1 PGR
39 plexiform neurofibroma 10.1 ESR1 PGR
40 paranasal sinus disease 10.1 ESR1 PGR
41 deafness, autosomal recessive 21 10.1 ESR1 PGR
42 atypical lipomatous tumor 10.1 ESR1 PGR
43 pediatric intraocular retinoblastoma 10.1 ESR1 PGR
44 congenital disorder of glycosylation, type ic 10.1 ESR1 PGR
45 intestinal perforation 10.1 ESR1 PGR
46 perlman syndrome 10.1 ESR1 PGR
47 congenital articular rigidity 10.1 AR MUC1
48 vulva basal cell carcinoma 10.1 ESR1 PGR
49 villoglandular endometrial endometrioid adenocarcinoma 10.1 ESR1 PGR
50 vaginal adenosarcoma 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to Apocrine Adenocarcinoma

Symptoms & Phenotypes for Apocrine Adenocarcinoma

MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ERBB2 ESR1 HPGD PGR PIP AR
2 endocrine/exocrine gland MP:0005379 9.73 ERBB2 ESR1 HPGD PGR PIP AR
3 integument MP:0010771 9.55 ERBB2 ESR1 MLPH PGR AR
4 neoplasm MP:0002006 9.26 AR ERBB2 ESR1 PGR
5 reproductive system MP:0005389 9.1 ERBB2 ESR1 HPGD PGR PIP AR

Drugs & Therapeutics for Apocrine Adenocarcinoma

Drugs for Apocrine Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
2
nivolumab Approved Phase 2 946414-94-4
3 Protein Kinase Inhibitors Phase 2
4 Antibodies Phase 2
5 Antibodies, Monoclonal Phase 2
6 Immunoglobulins Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Axitinib in R/M Salivary Gland Cancers of the Upper Aerodigestive Tract - SGC-AX14 Recruiting NCT02857712 Phase 2
2 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Not yet recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

Anatomical Context for Apocrine Adenocarcinoma

MalaCards organs/tissues related to Apocrine Adenocarcinoma:

39
Skin, Lymph Node, Breast, Ovary

Publications for Apocrine Adenocarcinoma

Articles related to Apocrine Adenocarcinoma:

(show all 40)
id Title Authors Year
1
Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases. ( 27818816 )
2016
2
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. ( 27668109 )
2016
3
Apocrine adenocarcinoma of the eyelid. ( 27500123 )
2016
4
Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma. ( 25657556 )
2015
5
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report. ( 26375389 )
2015
6
Axillary apocrine adenocarcinoma in a young male suspected initially on fine-needle aspiration cytology. ( 26729983 )
2015
7
Primary apocrine adenocarcinoma of the axilla. ( 26057510 )
2015
8
Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma. ( 23863550 )
2013
9
Apocrine adenocarcinoma of the vulva. ( 24179652 )
2013
10
Apocrine adenocarcinoma of the eyelid: case series and review. ( 24217473 )
2013
11
Primary apocrine adenocarcinoma of the eyelid. ( 22571743 )
2012
12
Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. ( 21913192 )
2012
13
Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. ( 18842349 )
2009
14
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation. ( 19784530 )
2009
15
Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. ( 19796468 )
2009
16
Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. ( 18631226 )
2008
17
Apocrine adenocarcinoma of the nipple: a case report. ( 18700029 )
2008
18
Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. ( 18713586 )
2008
19
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. ( 18982051 )
2008
20
Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. ( 17375797 )
2007
21
Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. ( 16961473 )
2006
22
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. ( 15677547 )
2005
23
Apocrine adenocarcinoma of the nipple: a case report. ( 15469170 )
2004
24
Primary apocrine adenocarcinoma with neuroendocrine differentiation occurring on the pubic skin. ( 14996118 )
2004
25
Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma). ( 11992376 )
2002
26
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case. ( 11940224 )
2002
27
Apocrine adenocarcinoma in a golden hamster. ( 11767064 )
2001
28
Radiologic case study. Apocrine adenocarcinoma. ( 9845457 )
1998
29
Parathyroid hormone/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy. ( 9135577 )
1997
30
Apocrine adenocarcinoma presenting as a large ulcerated axillary mass. ( 9236879 )
1997
31
A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. ( 8037297 )
1994
32
Apocrine adenocarcinoma arising in cystic teratoma of the ovary. ( 8503739 )
1993
33
Apocrine adenocarcinoma arising in Moll gland cystadenoma. ( 8233400 )
1993
34
Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. ( 1510222 )
1992
35
Apocrine adenocarcinoma of the bilateral axillae. ( 1785351 )
1991
36
Apocrine adenocarcinoma: case report and review of the literature. ( 2341662 )
1990
37
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. ( 2345942 )
1990
38
Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. ( 2175320 )
1990
39
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. ( 6322492 )
1984
40
Paget's disease of the vulva with underlying apocrine adenocarcinoma and local lymph node invasion. ( 6269104 )
1981

Variations for Apocrine Adenocarcinoma

Expression for Apocrine Adenocarcinoma

Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for Apocrine Adenocarcinoma

Pathways related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 AR ERBB2 ESR1 PGR
2
Show member pathways
11.17 ERBB2 ESR1 PGR
3
Show member pathways
10.92 AR ESR1
4
Show member pathways
10.75 AR ESR1 PGR

GO Terms for Apocrine Adenocarcinoma

Cellular components related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.13 ERBB2 MUC1 PIP
2 nuclear chromatin GO:0000790 8.8 AR ESR1 MUC1

Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.58 AR ERBB2 PIP
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.43 AR ESR1 PGR
3 intracellular receptor signaling pathway GO:0030522 9.37 AR ESR1
4 mammary gland alveolus development GO:0060749 9.32 AR ESR1
5 positive regulation of transcription from RNA polymerase III promoter GO:0045945 9.16 AR ERBB2
6 steroid hormone mediated signaling pathway GO:0043401 9.13 AR ESR1 PGR
7 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.62 AR ESR1 MUC1 PGR
2 lipid binding GO:0008289 9.61 AR ESR1 PGR
3 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 9.58 AR ESR1 PGR
4 protein dimerization activity GO:0046983 9.54 AR ERBB2 PIP
5 ATPase binding GO:0051117 9.43 AR ESR1 PGR
6 steroid hormone receptor activity GO:0003707 9.33 AR ESR1 PGR
7 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.13 AR ESR1 PGR
8 steroid binding GO:0005496 8.8 AR ESR1 PGR

Sources for Apocrine Adenocarcinoma

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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37 KEGG
38 LifeMap
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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