MCID: APC004
MIFTS: 38

Apocrine Adenocarcinoma malady

Categories: Rare diseases, Skin diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Apocrine Adenocarcinoma

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Aliases & Descriptions for Apocrine Adenocarcinoma:

Name: Apocrine Adenocarcinoma 11 13 67
Apocrine Carcinoma 11 47
Carcinoma of the Apocrine Gland 11
 
Carcinoma of Apocrine Gland 67
Apocrine Gland Carcinoma 11

Classifications:



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Disease Ontology11 DOID:4933
SNOMED-CT61 57141000

Summaries for Apocrine Adenocarcinoma

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Disease Ontology:11 An apocrine sweat gland cancer that derives from epithelial cells of glandular origin.

MalaCards based summary: Apocrine Adenocarcinoma, also known as apocrine carcinoma, is related to vulvar apocrine adenocarcinoma and breast apocrine carcinoma. An important gene associated with Apocrine Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways are FOXA1 transcription factor network and Integrated Pancreatic Cancer Pathway. Affiliated tissues include skin, salivary gland and lymph node, and related mouse phenotypes are limbs/digits/tail and neoplasm.

Related Diseases for Apocrine Adenocarcinoma

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Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1vulvar apocrine adenocarcinoma12.1
2breast apocrine carcinoma12.0
3breast apocrine carcinoma in situ11.9
4adenocarcinoma10.5
5breast granular cell tumor10.5ERBB2, PIP
6syringoma10.5MUC1, PIP
7heel spur10.5ERBB2, PIP
8vulva squamous cell carcinoma10.5ERBB2, PIP
9breast metaplastic carcinoma10.4MUC1, PGR
10breast papillary carcinoma10.4ERBB2, MUC1
11endometriosis of pelvic peritoneum10.4MUC1, PGR
12congenital structural myopathy10.4MUC1, PGR
13acute pulmonary heart disease10.4AR, PIP
14ossifying fibromyxoid tumor10.4ERBB2, PGR
15cutaneous mucoepidermoid carcinoma10.4ERBB2, PGR
16her2-receptor negative breast cancer10.4ERBB2, PGR
17bronchiolo-alveolar adenocarcinoma10.4ERBB2, MUC1
18serous surface papilloma10.4MUC1, PGR
19central centrifugal cicatricial alopecia10.4ERBB2, MUC1
20animal phobia10.4ERBB2, PGR
21vaginal adenosarcoma10.4ERBB2, PGR
22benign mesenchymoma10.4MUC1, PGR
23adenomyosis10.4ERBB2, MUC1
24parachordoma10.4MUC1, PGR
25focal chorioretinitis10.3ERBB2, PGR
26postcricoid region cancer10.3MUC1, PGR
27retinitis10.3ERBB2, PGR
28ovarian small cell carcinoma10.3ERBB2, PGR
29sideroblastic anemia pyridoxine-responsive autosomal recessive10.3AR, MUC1
30breast pericanalicular fibroadenoma10.3MUC1, PGR
31thymus adenocarcinoma10.3ESR1, PIP
32distal monosomy 9p10.3ERBB2, PGR
33chronic interstitial cystitis10.3MUC1, PGR
34papillary carcinoma10.3MUC1, PGR
35eyelid disease10.2ERBB2, ESR1
36lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy10.2MUC1, PGR
37bartholin's gland benign neoplasm10.2ESR1, MUC1
38extragonadal nonseminomatous germ cell tumor10.2ERBB2, ESR1
39vulvar angiokeratoma10.2ESR1, PGR
40central nervous system organ benign neoplasm10.2ESR1, PGR
41fallopian tube benign neoplasm10.2ESR1, PGR
42cervix endometrial stromal tumor10.2ERBB2, MUC1
43appendix leiomyoma10.2ESR1, PGR
44mixed cell adenoma10.2ESR1, PGR
45deafness, autosomal dominant 8/1210.2ESR1, PGR
46perinatal intestinal perforation10.2ESR1, PGR
47asthma susceptibility 510.2ESR1, PGR
48amyloid tumor10.2ESR1, PGR
49malignant mediastinal neurogenic neoplasm10.2ESR1, PGR
50pancreas lymphoma10.2ESR1, MUC1

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to apocrine adenocarcinoma

Symptoms for Apocrine Adenocarcinoma

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Drugs & Therapeutics for Apocrine Adenocarcinoma

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Drugs for Apocrine Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Axitinibapproved, investigationalPhase 2106319460-85-06450551
Synonyms:
319460-85-0
790713-39-2
AC-1539
AC1O51X3
AG 013736
AG-013736
AG-013736, Axitinib
AG-13736
AG013736
Axitinib
C503983
 
CID6450551
EC-000.2322
I14-1971
INLYTA
Inlyta
MolPort-006-392-413
N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
S1005_Selleck
ST51054130
UNII-C9LVQ0YUXG
ZINC03816287
axitinib
2
nivolumabapprovedPhase 2326946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
3Protein Kinase InhibitorsPhase 23612
4ImmunoglobulinsPhase 26045
5AntibodiesPhase 26045
6Antibodies, MonoclonalPhase 23795

Interventional clinical trials:

idNameStatusNCT IDPhase
1Axitinib in R/M Salivary Gland Cancers of the Upper Aerodigestive Tract - SGC-AX14RecruitingNCT02857712Phase 2
2Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin CancersNot yet recruitingNCT02978625Phase 2

Search NIH Clinical Center for Apocrine Adenocarcinoma

Genetic Tests for Apocrine Adenocarcinoma

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Anatomical Context for Apocrine Adenocarcinoma

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MalaCards organs/tissues related to Apocrine Adenocarcinoma:

35
Skin, Salivary gland, Lymph node, Breast, Ovary

Animal Models for Apocrine Adenocarcinoma or affiliated genes

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MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.5AR, ERBB2, ESR1, PGR
2MP:00020069.5AR, ERBB2, ESR1, PGR
3MP:00107719.0AR, ERBB2, ESR1, MLPH, PGR
4MP:00053858.1AR, ERBB2, ESR1, HPGD, PGR, PIP
5MP:00053848.1AR, ERBB2, ESR1, HPGD, PGR, PIP
6MP:00053798.1AR, ERBB2, ESR1, HPGD, PGR, PIP
7MP:00053897.3AR, ERBB2, ESR1, HPGD, PGR, PIP

Publications for Apocrine Adenocarcinoma

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Articles related to Apocrine Adenocarcinoma:

(show all 40)
idTitleAuthorsYear
1
Scrotal Apocrine Adenocarcinoma with Pagetoid Phenomenon and Inguinal Lymph Node Metastases. (27818816)
2016
2
Apocrine adenocarcinoma of the eyelid. (27500123)
2016
3
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. (27668109)
2016
4
Axillary apocrine adenocarcinoma in a young male suspected initially on fine-needle aspiration cytology. (26729983)
2015
5
Primary apocrine adenocarcinoma of the axilla. (26057510)
2015
6
Primary apocrine adenocarcinoma of scrotum suspected as urothelial carcinoma metastasis: A clinical and pathological dilemma. (25657556)
2015
7
Metastatic Cutaneous Apocrine Adenocarcinoma Treated With a Combination of Pertuzumab-Based Targeted Therapy and Taxane Chemotherapy: A Case Report. (26375389)
2015
8
Apocrine adenocarcinoma of the vulva. (24179652)
2013
9
Apocrine adenocarcinoma of the eyelid: case series and review. (24217473)
2013
10
Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma. (23863550)
2013
11
Primary apocrine adenocarcinoma of the eyelid. (22571743)
2012
12
Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. (21913192)
2012
13
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation. (19784530)
2009
14
Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. (18842349)
2009
15
Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. (19796468)
2009
16
Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. (18631226)
2008
17
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. (18982051)
2008
18
Apocrine adenocarcinoma of the nipple: a case report. (18700029)
2008
19
Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. (18713586)
2008
20
Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. (17375797)
2007
21
Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. (16961473)
2006
22
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. (15677547)
2005
23
Primary apocrine adenocarcinoma with neuroendocrine differentiation occurring on the pubic skin. (14996118)
2004
24
Apocrine adenocarcinoma of the nipple: a case report. (15469170)
2004
25
Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma). (11992376)
2002
26
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case. (11940224)
2002
27
Apocrine adenocarcinoma in a golden hamster. (11767064)
2001
28
Radiologic case study. Apocrine adenocarcinoma. (9845457)
1998
29
Parathyroid hormone/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy. (9135577)
1997
30
Apocrine adenocarcinoma presenting as a large ulcerated axillary mass. (9236879)
1997
31
A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. (8037297)
1994
32
Apocrine adenocarcinoma arising in cystic teratoma of the ovary. (8503739)
1993
33
Apocrine adenocarcinoma arising in Moll gland cystadenoma. (8233400)
1993
34
Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. (1510222)
1992
35
Apocrine adenocarcinoma of the bilateral axillae. (1785351)
1991
36
Apocrine adenocarcinoma: case report and review of the literature. (2341662)
1990
37
Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. (2175320)
1990
38
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. (2345942)
1990
39
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. (6322492)
1984
40
Paget's disease of the vulva with underlying apocrine adenocarcinoma and local lymph node invasion. (6269104)
1981

Variations for Apocrine Adenocarcinoma

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Expression for genes affiliated with Apocrine Adenocarcinoma

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Search GEO for disease gene expression data for Apocrine Adenocarcinoma.

Pathways for genes affiliated with Apocrine Adenocarcinoma

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Pathways related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5AR, ESR1
29.1AR, ERBB2, ESR1
3
Show member pathways
9.1AR, ESR1, PGR

GO Terms for genes affiliated with Apocrine Adenocarcinoma

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Cellular components related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:00007909.2AR, ESR1, MUC1
2apical plasma membraneGO:00163248.8ERBB2, MUC1, PIP

Biological processes related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase III promoterGO:004594510.0AR, ERBB2
2mammary gland alveolus developmentGO:00607499.7AR, ESR1
3transcription initiation from RNA polymerase II promoterGO:00063679.4AR, ESR1, PGR
4positive regulation of gene expressionGO:00106289.0AR, ERBB2, PIP

Molecular functions related to Apocrine Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid hormone receptor activityGO:000370710.1ESR1, PGR
2RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:000487910.1AR, ESR1
3steroid bindingGO:00054969.3AR, ESR1, PGR
4transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010779.2AR, ESR1, PGR
5ATPase bindingGO:00511179.0AR, ESR1, PGR
6RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009788.7AR, ESR1, MUC1, PGR
7protein dimerization activityGO:00469838.7AR, ERBB2, PIP

Sources for Apocrine Adenocarcinoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet