MCID: APC004
MIFTS: 35

Apocrine Adenocarcinoma malady

Rare diseases, Cancer diseases, Endocrine diseases categories
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Summaries for Apocrine Adenocarcinoma

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Apocrine carcinoma is a cancer of a sweat gland.  apocrine carcionoma most often develops under the arm (the axilla), but it can develop on the scalp or other parts of the body.  the cause of apocrine carcinoma is unknown.  apocrine carcinoma usually appears as a single, small, painless bump (nodule) that can vary in color and slowly increases in size.  the average age at the time of diagnosis is 62 years of age, and twice as many men are affected than women.  most apocrine carcinomas can be treated and are not fatal.  treatment of apocrine carcinoma is surgery to remove as much of the cancer as possible.  additional treatments such as radiation therapy and chemotherapy have been used to treat this condition, but the usefulness of these treatments is unproven. last updated: 6/16/2014

MalaCards: Apocrine Adenocarcinoma, also known as apocrine gland carcinoma, is related to adenocarcinoma and breast cancer. An important gene associated with Apocrine Adenocarcinoma is PTHLH (parathyroid hormone-like hormone). The compounds dihydrotestosterone and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and skin, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Apocrine Adenocarcinoma

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8Disease Ontology, 43NIH Rare Diseases, 62UMLS, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

apocrine adenocarcinoma 8 62
apocrine gland carcinoma 8 62
apocrine carcinoma 8 43
carcinoma of the apocrine gland 8


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Disease Ontology8 DOID:4933
SNOMED-CT58 57141000

Related Diseases for Apocrine Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Apocrine Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2PTHLH, PIP
2breast cancer30.1PTHLH, PIP
3vulvar apocrine adenocarcinoma10.4
4breast apocrine carcinoma10.4
5sweat gland carcinoma10.4
6breast apocrine carcinoma in situ10.3
7neuroendocrine carcinoma10.3
8apocrine adenoma10.3
9adenoma10.3
10lipid-rich carcinoma10.2
11cystadenoma10.1
12breast adenocarcinoma10.1
13cystic teratoma10.1
14teratoma10.1
15male breast cancer10.1
16adenoiditis10.1
17adenoid cystic carcinoma10.1
18cellulitis10.1
19lung cancer10.0PTHLH, PIP
20tongue squamous cell carcinoma10.0PIP, PTHLH
21prostate cancer9.9PTHLH, PIP

Graphical network of the top 20 diseases related to Apocrine Adenocarcinoma:



Diseases related to apocrine adenocarcinoma

Symptoms for Apocrine Adenocarcinoma

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Drugs & Therapeutics for Apocrine Adenocarcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Apocrine Adenocarcinoma

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Anatomical Context for Apocrine Adenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Apocrine Adenocarcinoma:

33
Lymph node, Breast, Skin, Ovary

Animal Models for Apocrine Adenocarcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Apocrine Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.1PTHLH, PIP
2MP:00053818.8PTHLH, PIP

Publications for Apocrine Adenocarcinoma

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52PubMed
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Articles related to Apocrine Adenocarcinoma:

(show all 33)
idTitleAuthorsYear
1
Apocrine adenocarcinoma of the vulva. (24179652)
2013
2
Apocrine adenocarcinoma of the eyelid: case series and review. (24217473)
2013
3
Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma. (23863550)
2013
4
Primary apocrine adenocarcinoma of the eyelid. (22571743)
2012
5
Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm. (21913192)
2012
6
The elusive differential diagnosis of cutaneous apocrine adenocarcinoma vs. metastasis: the current role of clinical correlation. (19784530)
2009
7
Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. (18842349)
2009
8
Primary apocrine adenocarcinoma of the scrotum with distant metastasis: a case report. (19796468)
2009
9
Localised radiotherapy for a ferret with possible anal sac apocrine adenocarcinoma. (18631226)
2008
10
Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. (18982051)
2008
11
Apocrine adenocarcinoma of the nipple: a case report. (18700029)
2008
12
Invasive primary ductal apocrine adenocarcinoma of axilla: a case report with immunohistochemical profiling and a review of literature. (18713586)
2008
13
Infiltrating apocrine adenocarcinoma with extramammary pagetoid spread. (17375797)
2007
14
Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. (16961473)
2006
15
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. (15677547)
2005
16
Primary apocrine adenocarcinoma with neuroendocrine differentiation occurring on the pubic skin. (14996118)
2004
17
Apocrine adenocarcinoma of the nipple: a case report. (15469170)
2004
18
Aspiration biopsy in a case of apocrine adenocarcinoma with foam cells (myoblastomatoid or histiocytoid adenocarcinoma). (11992376)
2002
19
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: report of a case. (11940224)
2002
20
Apocrine adenocarcinoma in a golden hamster. (11767064)
2001
21
Radiologic case study. Apocrine adenocarcinoma. (9845457)
1998
22
Apocrine adenocarcinoma presenting as a large ulcerated axillary mass. (9236879)
1997
23
Parathyroid hormone/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy. (9135577)
1997
24
A case of apocrine adenocarcinoma associated with hamartomatous apocrine gland hyperplasia of both axillae. (8037297)
1994
25
Apocrine adenocarcinoma arising in cystic teratoma of the ovary. (8503739)
1993
26
Apocrine adenocarcinoma arising in Moll gland cystadenoma. (8233400)
1993
27
Complex adnexal tumor of the primary epithelial germ with distinct patterns of superficial epithelioma with sebaceous differentiation, immature trichoepithelioma, and apocrine adenocarcinoma. (1510222)
1992
28
Apocrine adenocarcinoma of the bilateral axillae. (1785351)
1991
29
Apocrine adenocarcinoma: case report and review of the literature. (2341662)
1990
30
Extramammary Paget's disease: comparative histopathologic studies of intraductal carcinoma of the breast and apocrine adenocarcinoma. (2175320)
1990
31
Identification of parathyroid hormone-related protein in canine apocrine adenocarcinoma of the anal sac. (2345942)
1990
32
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. (6322492)
1984
33
Paget's disease of the vulva with underlying apocrine adenocarcinoma and local lymph node invasion. (6269104)
1981

Variations for Apocrine Adenocarcinoma

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Expression for genes affiliated with Apocrine Adenocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Apocrine Adenocarcinoma

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Pathways for genes affiliated with Apocrine Adenocarcinoma

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Compounds for genes affiliated with Apocrine Adenocarcinoma

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Apocrine Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dihydrotestosterone45 29 24 1112.3PTHLH, PIP
2tamoxifen45 51 29 1112.3PTHLH, PIP
3estradiol45 24 1111.2PTHLH, PIP
4paraffin459.2PTHLH, PIP
5progesterone45 29 61 24 1113.1PIP, PTHLH
6estrogen459.1PTHLH, PIP
7testosterone45 61 24 1112.0PTHLH, PIP
8steroid458.8PTHLH, PIP

GO Terms for genes affiliated with Apocrine Adenocarcinoma

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16Gene Ontology
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Cellular components related to Apocrine Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1PTHLH, PIP

Products for genes affiliated with Apocrine Adenocarcinoma

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Sources for Apocrine Adenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet