MCID: APC002
MIFTS: 23

Apocrine Adenosis of Breast malady

Summaries for Apocrine Adenosis of Breast

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Apocrine Adenosis of Breast, also known as apocrine adenosis of the breast, is related to uterine carcinosarcoma and bilateral breast cancer. An important gene associated with Apocrine Adenosis of Breast is PGR (progesterone receptor), and among its related pathways is PIP3 activates AKT signaling. The compounds megestrol acetate and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include breast.

Aliases & Classifications for Apocrine Adenosis of Breast

About this section
Sources:
8Disease Ontology, 39NCIt, 60UMLS
See all sources

Aliases & Descriptions:

apocrine adenosis of breast 8
apocrine adenosis of the breast 8


External Ids:

Disease Ontology8 DOID:5999
NCIt39 C5198

Related Diseases for Apocrine Adenosis of Breast

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of diseases related to Apocrine Adenosis of Breast:



Diseases related to apocrine adenosis of breast

Clinical Features for Apocrine Adenosis of Breast

About this section

Drugs & Therapeutics for Apocrine Adenosis of Breast

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Apocrine Adenosis of Breast

Drug clinical trials:

Search ClinicalTrials for Apocrine Adenosis of Breast

Search NIH Clinical Center for Apocrine Adenosis of Breast

Search CenterWatch for Apocrine Adenosis of Breast

Genetic Tests for Apocrine Adenosis of Breast

About this section

Anatomical Context for Apocrine Adenosis of Breast

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Apocrine Adenosis of Breast:

32
Breast

Animal Models for Apocrine Adenosis of Breast or affiliated genes

About this section

Publications for Apocrine Adenosis of Breast

About this section
Sources:
50PubMed
See all sources

Articles related to Apocrine Adenosis of Breast:

idTitleAuthorsYear
1
Massive myoepithelial proliferation (myoepitheliosis) with lumpy deposits of basement membrane material closely associated with apocrine adenosis and ductal carcinoma in situ of the breast. (21951673)
2011
2
Cell turnover in apocrine metaplasia and apocrine adenosis of the breast. (20123450)
2010
3
Cell cycle alterations and their relationship to proliferation in apocrine adenosis of the breast. (19236511)
2009
4
Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia. (19383289)
2007
5
Expression of c-erbB2, p53, Bcl-2, Bax, c-myc and Ki-67 in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. (12447674)
2002
6
C-myc oncoprotein expression and gene amplification in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. (14965711)
2002
7
c-erbB2 oncoprotein expression, gene amplification, and chromosome 17 aneusomy in apocrine adenosis of the breast. (10861572)
2000
8
Immunohistochemical localisation of androgen receptor in apocrine metaplasia and apocrine adenosis of the breast: relation to oestrogen and progesterone receptors. (10690175)
1999
9
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. (8422116)
1993

Genetic Variations for Apocrine Adenosis of Breast

About this section

Expression for genes affiliated with Apocrine Adenosis of Breast

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Apocrine Adenosis of Breast

Search GEO for disease gene expression data for Apocrine Adenosis of Breast.

Pathways for genes affiliated with Apocrine Adenosis of Breast

About this section
Sources:
53Reactome
See all sources

Pathways related to Apocrine Adenosis of Breast according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1ERBB2, PGR

Compounds for genes affiliated with Apocrine Adenosis of Breast

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Apocrine Adenosis of Breast according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1megestrol acetate449.5ERBB2, PGR
2anastrozole44 1110.5ERBB2, PGR
3capecitabine44 49 1111.5ERBB2, PGR
4exemestane49 44 59 1112.5ERBB2, PGR
5lapatinib44 49 1111.5PGR, ERBB2
6toremifene44 1110.5ERBB2, PGR
7fulvestrant44 49 28 1112.5ERBB2, PGR
8letrozole44 49 59 1112.5PGR, ERBB2
9taxane449.5PGR, ERBB2
10leucovorin44 49 1111.5ERBB2, PGR
11raloxifene44 28 49 1112.5ERBB2, PGR
12trastuzumab44 49 1111.5PGR, ERBB2
134-hydroxytamoxifen449.5ERBB2, PGR
14progestin449.4ERBB2, PGR
15geldanamycin44 49 59 1112.4ERBB2, PGR
16resveratrol44 59 11 2412.4PGR, ERBB2
17adriamycin449.4ERBB2, PGR
18docetaxel44 49 59 1112.4ERBB2, PGR
19cyclophosphamide44 49 1111.4ERBB2, PGR
20folate449.4PGR, ERBB2
21methotrexate44 49 1111.4ERBB2, PGR
22gnrh449.3ERBB2, PGR
235fluorouracil449.3PGR, ERBB2
24agar449.3ERBB2, PGR
25tamoxifen44 49 28 1112.2ERBB2, PGR
26paclitaxel44 49 1111.2ERBB2, PGR
27doxorubicin44 49 1111.1PGR, ERBB2
28aspartate449.1ERBB2, PGR
29paraffin449.0ERBB2, PGR
30genistein44 28 59 2 11 2413.8ERBB2, PGR

GO Terms for genes affiliated with Apocrine Adenosis of Breast

About this section

Products for genes affiliated with Apocrine Adenosis of Breast

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Apocrine Adenosis of Breast

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet